MKK6

By Targets:	Apoptosis (2) Bacterial (1) Calcium Channel (1) CCR (1) CXCR (1) JNK (4) MEK (1) p38 MAPK (3) PKC (3) Raf (2) Reference Standards (2) Small Interfering RNA (siRNA) (3)
By Research Areas:	Cancer (6) Cardiovascular Disease (3) Infection (2) Inflammation/Immunology (1) Metabolic Disease (1) Neurological Disease (3)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-119917

Gossypetin 4 Publications Verification	p38 MAPK MEK Bacterial	Infection Cancer
Gossypetin is a hexahydroxylated flavonoid and is a potent mitogen-activated protein kinase kinase (MKK)3 and *MKK6* inhibitor with strongly attenuates the *MKK3/6-p38* signaling pathway, has various pharmacological activities, including antioxidant, antibacterial and anticancer activities .

HY-10542

GW 5074 5+ Cited Publications	Raf Apoptosis	Cancer
GW 5074 is a potent and selective c-Raf inhibitor with IC₅₀ of 9 nM, and has no effect on the activities of JNK1/2/3, MEK1, MKK6/7, CDK1/2, c-Src, p38 MAP, VEGFR2 or c-Fms .

HY-13866

Ro 31-8220 mesylate Maximum Cited Publications 13 Publications Verification Ro 31-8220 methanesulfonate; Bisindolylmaleimide IX mesylate	PKC JNK	Cardiovascular Disease Neurological Disease Cancer
Ro 31-8220 mesylate is a potent PKC inhibitor, with IC₅₀s of 5, 24, 14, 27, 24 and 23 nM for PKCα, PKCβI, PKCβII, PKCγ, PKCε and rat brain PKC, respectively. Ro 31-8220 also significantly inhibits MAPKAP-K1b, MSK1, S6K1 and GSK3β (IC₅₀s, 3, 8, 15, and 38 nM, respectively), with no effect on MKK3, MKK4, MKK6 and MKK7. Ro 31-8220 mesylate can also inhibit the expression of MKP-1, induce the expression of c-Jun, and activate JNK, and these effects possess pharmacological properties independent of PKC .

HY-13866A

Ro 31-8220 Bisindolylmaleimide IX	PKC JNK	Cardiovascular Disease Neurological Disease
Ro 31-8220 is a potent PKC inhibitor, with IC₅₀s of 5, 24, 14, 27, 24 and 23 nM for PKCα, PKCβI, PKCβII, PKCγ, PKCε and rat brain PKC, respectively. Ro 31-8220 also significantly inhibits MAPKAP-K1b, MSK1, S6K1 and GSK3β (IC₅₀s, 3, 8, 15, and 38 nM, respectively), with no effect on MKK3, MKK4, MKK6 and MKK7. Ro 31-8220 can also inhibit the expression of MKP-1, induce the expression of c-Jun, and activate JNK, and these effects possess pharmacological properties independent of PKC .

HY-E70759

MKK6 SDTD Recombinant Human Active Protein Kinase	p38 MAPK	Cancer
The mitogen-activated protein kinase kinase 6 (MKK6) is one of the upstream activators of p38 MAPK. MKK6 activates myocardial cell NF-κB and inhibits apoptosis in a p38 MAPK-dependent manner. MKK6 SDTD is a mutant of MKK6. MKK6 SDTD Recombinant Human Active Protein Kinase is a recombinant MKK6 SDTD protein that can be used to study MKK6 SDTD-related functions .

HY-N11723

Catenarin Katenarin	CCR CXCR p38 MAPK JNK Calcium Channel	Infection Metabolic Disease Inflammation/Immunology
Catenarin, an anthraquinone compound, inhibits CCR5- and CXCR4-mediated chemotaxis. Catenarin reduces the phosphorylation of mitogen-activated protein kinases (p38 and JNK) and their upstream kinases (MKK6 and *MKK7*), and calcium mobilization. Catenarin shows anti-inflammatory effect and suppresses leukocyte migration in the diabetes. Catenarin exhibits significant inhibitory effects against Gram-positive bacteria. Catenarin prevents type 1 diabetes (T1D) in nonobese diabetic mice ^[1][2].

HY-10542R

GW 5074 (Standard)	Reference Standards Raf Apoptosis	Cancer
GW 5074 (Standard) is the analytical standard of GW 5074 (HY-10542). This product is intended for research and analytical applications. GW 5074 is a potent and selective c-Raf inhibitor with IC₅₀ of 9 nM, and has no effect on the activities of JNK1/2/3, MEK1, MKK6/7, CDK1/2, c-Src, p38 MAP, VEGFR2 or c-Fms .

HY-RS17782

Map2k6 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Map2k6 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Map2k6 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Map2k6 Mouse Pre-designed siRNA Set A Map2k6 Mouse Pre-designed siRNA Set A

HY-RS08044

MAP2K6 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
MAP2K6 Human Pre-designed siRNA Set A contains three designed siRNAs for MAP2K6 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

MAP2K6 Human Pre-designed siRNA Set A MAP2K6 Human Pre-designed siRNA Set A

HY-13866R

Ro 31-8220 mesylate (Standard) Ro 31-8220 methanesulfonate (Standard); Bisindolylmaleimide IX mesylate (Standard)	PKC JNK Reference Standards	Cardiovascular Disease Neurological Disease Cancer
Ro 31-8220 mesylate (Standard) is the analytical standard of Ro 31-8220 mesylate (HY-13866). This product is intended for research and analytical applications. Ro 31-8220 mesylate is a potent PKC inhibitor, with IC₅₀s of 5, 24, 14, 27, 24 and 23 nM for PKCα, PKCβI, PKCβII, PKCγ, PKCε and rat brain PKC, respectively. Ro 31-8220 also significantly inhibits MAPKAP-K1b, MSK1, S6K1 and GSK3β (IC₅₀s, 3, 8, 15, and 38 nM, respectively), with no effect on MKK3, MKK4, MKK6 and MKK7. Ro 31-8220 mesylate can also inhibit the expression of MKP-1, induce the expression of c-Jun, and activate JNK, and these effects possess pharmacological properties independent of PKC .

HY-RS24249

Map2k6 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Map2k6 Rat Pre-designed siRNA Set A contains three designed siRNAs for Map2k6 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Map2k6 Rat Pre-designed siRNA Set A Map2k6 Rat Pre-designed siRNA Set A

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-119917

Gossypetin 4 Publications Verification	Infection Flavonols Flavonoids Classification of Application Fields Rhodiola rosea Linn. Crassulaceae Phenols Polyphenols Plants Disease Research Fields Source Classification	p38 MAPK MEK Bacterial
Gossypetin is a hexahydroxylated flavonoid and is a potent mitogen-activated protein kinase kinase (MKK)3 and *MKK6* inhibitor with strongly attenuates the *MKK3/6-p38* signaling pathway, has various pharmacological activities, including antioxidant, antibacterial and anticancer activities .

HY-N11723

Catenarin Katenarin	Quinones Microorganisms Anthraquinones Source Classification	CCR CXCR p38 MAPK JNK Calcium Channel
Catenarin, an anthraquinone compound, inhibits CCR5- and CXCR4-mediated chemotaxis. Catenarin reduces the phosphorylation of mitogen-activated protein kinases (p38 and JNK) and their upstream kinases (MKK6 and *MKK7*), and calcium mobilization. Catenarin shows anti-inflammatory effect and suppresses leukocyte migration in the diabetes. Catenarin exhibits significant inhibitory effects against Gram-positive bacteria. Catenarin prevents type 1 diabetes (T1D) in nonobese diabetic mice ^[1][2].

Species:	Human (6)
Tag:	His (4) Tag Free (2) GST (2)
Source:	Sf9 insect cells (6)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P73811A

	MKK6 Protein, Human (S207D, T211D, sf9, His) MAPKK6; MEK6; MKK6; PRKMK6; SAPKK-3; SAPKK3	Human	Sf9 insect cells
	The MKK6 protein is a dual-specificity kinase involved in the MAP kinase pathway. MKK6 Protein, Human (S207D, T211D, sf9, His) is the recombinant human-derived MKK6 protein, expressed by Sf9 insect cells, with N-6*His labeled tag.

HY-P73811

	MKK6 Protein, Human (Active, S207D, T211D, sf9, His-GST) MAPKK6; MEK6; MKK6; PRKMK6; SAPKK-3; SAPKK3	Human	Sf9 insect cells
	The MKK6 protein is a dual-specificity kinase involved in the MAP kinase pathway. MKK6 Protein, Human (S207D, T211D, sf9, His-GST) is the recombinant human-derived MKK6 protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag.

HY-P74746

	MKK6 Protein, Human (sf9) Dual specificity mitogen-activated protein kinase kinase 6; MAPKK 6; MEK 6; SAPKK3; MAP2K6	Human	Sf9 insect cells
	The MKK6 protein is a dual-specificity kinase involved in the MAP kinase pathway. MKK6 Protein, Human (sf9) is the recombinant human-derived MKK6 protein, expressed by Sf9 insect cells, with tag free and additional two amino acids (Gly & Pro) at the N-terminus.

HY-P74745

	MKK6 Protein, Human (sf9, His-GST) Dual specificity mitogen-activated protein kinase kinase 6; MAPKK 6; MEK 6; SAPKK3; MAP2K6	Human	Sf9 insect cells
	The MKK6 protein is a dual-specificity kinase involved in the MAP kinase pathway. MKK6 Protein, Human (sf9, His-GST) is the recombinant human-derived MKK6 protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag.

HY-P74748

	MKK6 Protein, Human (S207D, T211D, sf9) Dual specificity mitogen-activated protein kinase kinase 6; MAPKK 6; MEK 6; SAPKK3; MAP2K6	Human	Sf9 insect cells
	The MKK6 protein is a dual-specificity kinase involved in the MAP kinase pathway. MKK6 Protein, Human (S207D, T211D, sf9) is the recombinant human-derived MKK6 protein, expressed by Sf9 insect cells, with tag free.

HY-P700592

	MAP2K6 Protein, Human (sf9, His) MAP2K6; mitogen-activated protein kinase kinase 6; MEK6; MKK6; MAPKK6; PRKMK6; SAPKK3; protein kinase, mitogen-activated, kinase 6 (MAP kinase kinase 6); EC 2.7.12.2; Dual specificity mitogen-activated protein kinase kinase 6; MAP kinase kinase 6; MAPK/ERK kinase 6	Human	Sf9 insect cells
	The MKK6 protein is a dual-specificity kinase involved in the MAP kinase pathway. MAP2K6 Protein, Human (sf9, His) is the recombinant human-derived MAP2K6 protein, expressed by sf9 insect cells , with N-6*His labeled tag.

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Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

Host:	Mouse (4) Rabbit (6)
Reactivity:	Human (10) Rat (7) Mouse (8)
Application:	IHC-P (2) ICC/IF (6) IP (7) WB (10) FC (4) ELISA (2)
Isotype:	IgG (6) IgG1 (4)
Conjugation:	Non-conjugated (10)
Clonality:	Monoclonal (5) Recombinant (3)
Modification:	Unmodified (5)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P84382

	MAP2K6 Antibody (YA4079) MEK6; MKK6; MAPKK6; PRKMK6; SAPKK3; MAP2K6	WB, ICC/IF, FC, ELISA	Human, Mouse
	MAP2K6 Antibody (YA4079) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to MAP2K6.

HY-P84382A

	MAP2K6 Antibody (YA4079)(PBS only) MEK6; MKK6; MAPKK6; PRKMK6; SAPKK3; MAP2K6	WB, ICC/IF, FC, ELISA	Human, Mouse
	MAP2K6 Antibody (YA4079) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to MAP2K6.

HY-P83578

	MEK3+MEK6 Antibody (YA3323) MEK6; MKK6; MAPKK6; PRKMK6; SAPKK3; MAP2K6; MEK3; MAP kinase kinase 3; MAPKK3; MAPK/ERK kinase 3	WB, IHC-P, ICC/IF, IP, FC	Human, Mouse, Rat
	MEK3+MEK6 Antibody (YA3323) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to MEK3+MEK6.

HY-P83578A

	MEK3+MEK6 Antibody (YA3323)(PBS only) MEK6; MKK6; MAPKK6; PRKMK6; SAPKK3; MAP2K6; MEK3; MAP kinase kinase 3; MAPKK3; MAPK/ERK kinase 3	WB, IHC-P, ICC/IF, IP, FC	Human, Mouse, Rat
	MEK3+MEK6 Antibody (YA3323) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to MEK3+MEK6.

HY-P85276

	MAP2K6 Antibody (YA4968) MAP2K6; MEK6; MKK6; PRKMK6; SKK3; Dual specificity mitogen-activated protein kinase kinase 6; MAP kinase kinase 6; MAPKK 6; MAPK/ERK kinase 6; MEK 6; Stress-activated protein kinase kinase 3; SAPK kinase 3; SAPKK-3; SAPKK3	WB, IP	Human, Mouse, Rat
	MAP2K6 Antibody (YA4968) is a Rabbit-derived and non-conjugated recomninant monoclonal antibody, targeting to MAP2K6.

HY-P81343

	MAP2K6 Antibody (YA1088) MAP2K6; MEK6; MKK6; PRKMK6; SKK3; Dual specificity mitogen-activated protein kinase kinase 6; MAP kinase kinase 6; MAPKK 6; MAPK/ERK kinase 6; MEK 6; Stress-activated protein kinase kinase 3; SAPK kinase 3; SAPKK-3; SAPKK3	WB, IP	Human, Rat
	MAP2K6 Antibody (YA1088) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to MAP2K6.

HY-P81343A

	MAP2K6 Antibody (YA1088)(PBS only) MAP2K6; MEK6; MKK6; PRKMK6; SKK3; Dual specificity mitogen-activated protein kinase kinase 6; MAP kinase kinase 6; MAPKK 6; MAPK/ERK kinase 6; MEK 6; Stress-activated protein kinase kinase 3; SAPK kinase 3; SAPKK-3; SAPKK3	WB, IP	Human, Rat
	MAP2K6 Antibody (YA1088) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to MAP2K6.

HY-P83469

	MEK3 Antibody (YA3214) AW212142; dual specificity mitogen activated protein kinase kinase 3; Dual specificity mitogen activated protein kinase kinase 6; Dual specificity mitogen-activated protein kinase kinase 3; MAP kinase kinase 3; MAP kinase kinase 6; map2k3; MAP2K6; MAPK ERK kinase 3; MAPK/ERK kinase 3; MAPK/ERK kinase 6; MAPKK 3; MAPKK 6; MAPKK3; MAPKK6; MEK 3; MEK 6; MEK3; Mitogen activated protein kinase kinase 3; Mitogen activated protein kinase kinase 6; MKK 3; MKK3; MKK6; mMKK3b; MP2K3_HUMAN; PRKMK 3; PRKMK3; PRKMK6; Protein kinase; mitogen activated; kinase 6 (MAP kinase kinase 6); protein kinase; mitogen-activated; kinase 3; SAPK kinase 2; SAPKK 2; SAPKK 3; SAPKK-2; SAPKK2; SAPKK3; Stress activated protein kinase kinase 2; Stress activated protein kinase kinase 3; Stress-activated protein kinase kinase 2.	WB, ICC/IF, IP	Human, Mouse, Rat
	MEK3 Antibody (YA3214) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to MEK3.

HY-P83469A

	MEK3 Antibody (YA3214)(PBS only) AW212142; dual specificity mitogen activated protein kinase kinase 3; Dual specificity mitogen activated protein kinase kinase 6; Dual specificity mitogen-activated protein kinase kinase 3; MAP kinase kinase 3; MAP kinase kinase 6; map2k3; MAP2K6; MAPK ERK kinase 3; MAPK/ERK kinase 3; MAPK/ERK kinase 6; MAPKK 3; MAPKK 6; MAPKK3; MAPKK6; MEK 3; MEK 6; MEK3; Mitogen activated protein kinase kinase 3; Mitogen activated protein kinase kinase 6; MKK 3; MKK3; MKK6; mMKK3b; MP2K3_HUMAN; PRKMK 3; PRKMK3; PRKMK6; Protein kinase; mitogen activated; kinase 6 (MAP kinase kinase 6); protein kinase; mitogen-activated; kinase 3; SAPK kinase 2; SAPKK 2; SAPKK 3; SAPKK-2; SAPKK2; SAPKK3; Stress activated protein kinase kinase 2; Stress activated protein kinase kinase 3; Stress-activated protein kinase kinase 2.	WB, ICC/IF, IP	Human, Mouse, Rat
	MEK3 Antibody (YA3214) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to MEK3.

HY-P810590

	Phospho-MEK3 (Ser189)+MEK6 (Ser207) Antibody (YA9854) AW212142; dual specificity mitogen activated protein kinase kinase 3; Dual specificity mitogen activated protein kinase kinase 6; Dual specificity mitogen-activated protein kinase kinase 3; MAP kinase kinase 3; MAP kinase kinase 6; map2k3; MAP2K6; MAPK ERK kinase 3; MAPK/ERK kinase 3; MAPK/ERK kinase 6; MAPKK 3; MAPKK 6; MAPKK3; MAPKK6; MEK 3; MEK 6; MEK3; Mitogen activated protein kinase kinase 3; Mitogen activated protein kinase kinase 6; MKK 3; MKK3; MKK6; mMKK3b; MP2K3_HUMAN; PRKMK 3; PRKMK3; PRKMK6; Protein kinase; mitogen activated; kinase 6 (MAP kinase kinase 6); protein kinase; mitogen-activated; kinase 3; SAPK kinase 2; SAPKK 2; SAPKK 3; SAPKK-2; SAPKK2; SAPKK3; Stress activated protein kinase kinase 2; Stress activated protein kinase kinase 3; Stress-activated protein kinase kinase 2.	WB	Human, Mouse
	Phospho-MEK3 (Ser189)+MEK6 (Ser207) Antibody (YA9854) is a Rabbit-derived and non-conjugated IgG Recombinant, Monoclonal antibody, targeting to Phospho-MEK3 (Ser189)+MEK6 (Ser207).

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Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

Cat. No.	Product Name		Classification

HY-RS17782

Map2k6 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Map2k6 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Map2k6 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS08044

MAP2K6 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
MAP2K6 Human Pre-designed siRNA Set A contains three designed siRNAs for MAP2K6 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS24249

Map2k6 Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Map2k6 Rat Pre-designed siRNA Set A contains three designed siRNAs for Map2k6 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

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