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Isoforms Recommended:	MMP-12

Results for "

MMP-12

" in MedChemExpress (MCE) Product Catalog:

By Targets:	MMP (11) Small Interfering RNA (siRNA) (3)
By Research Areas:	Cancer (2) Cardiovascular Disease (1) Inflammation/Immunology (8)

Inhibitors & Agonists

Peptides

Recombinant Proteins

Antibodies

Targets Recommended: MMP URAT1

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-RS08522

MMP12 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
MMP12 Human Pre-designed siRNA Set A contains three designed siRNAs for MMP12 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

MMP12 Human Pre-designed siRNA Set A MMP12 Human Pre-designed siRNA Set A

HY-RS08523

Mmp12 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Mmp12 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Mmp12 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Mmp12 Mouse Pre-designed siRNA Set A Mmp12 Mouse Pre-designed siRNA Set A

HY-RS08524

Mmp12 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Mmp12 Rat Pre-designed siRNA Set A contains three designed siRNAs for Mmp12 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Mmp12 Rat Pre-designed siRNA Set A Mmp12 Rat Pre-designed siRNA Set A

HY-130391

MMP12-IN-3	MMP	Inflammation/Immunology
MMP12-IN-3 (compound 32) is a potent *MMP12* inhibitor with an IC₅₀ value of 4.9 nM. MMP12-IN-3 has the potential for the research of chronic respiratory diseases such as emphysema .

HY-120944

BAY-7598	MMP	Inflammation/Immunology
BAY-7598 is a potent, orally bioavailable, and selective *MMP12* inhibitor probe with IC₅₀s of 0.085, 0.67 and 1.1 nM for human MMP12, murine MMP12, and rat MMP12, respectively .

HY-P4521

Ac-Pro-Leu-Gly-[(S)-2-mercapto-4-methyl-pentanoyl]-Leu-Gly-OEt	MMP	Others
Ac-Pro-Leu-Gly-[(S)-2-mercapto-4-methyl-pentanoyl]-Leu-Gly-OEt is a *MMP12* substrate, and can be used to detect MMP12 enzyme activity .

HY-14155

MMP145

MMP Inflammation/Immunology

MMP145 (compound 27) is a potent, selective and orally active MMP-12 inhibitor. MMP145 is effective in inflammation and asthma reasearch .

MMP145	MMP	Inflammation/Immunology
MMP145 (compound 27) is a potent, selective and orally active *MMP-12* inhibitor. MMP145 is effective in inflammation and asthma reasearch .

HY-114091

PF-00356231 hydrochloride 1 Publications Verification	MMP	Inflammation/Immunology
PF-00356231 hydrochloride is a specific, non-peptidic, non-zinc chelating ligand and inhibitor of matrix metalloproteinase *MMP-12* (IC₅₀=1.4 μM). PF-00356231 hydrochloride binds to MMP-12 and forms PF-00356231/MMP-12 complex. PF-00356231 hydrochloride shows potency against MMP-13, MMP-8, MMP-9, MMP-3 with IC₅₀s of 0.00065, 1.7, 0.98, 0.39 μM, respectively .

HY-114091A

PF-00356231	MMP	Inflammation/Immunology
PF-00356231 hydrochloride is a specific, non-peptidic, non-zinc chelating ligand and inhibitor of matrix metalloproteinase *MMP-12* (IC₅₀=1.4 μM). PF-00356231 hydrochloride binds to MMP-12 and forms PF-00356231/MMP-12 complex. PF-00356231 hydrochloride shows potency against MMP-13, MMP-8, MMP-9, MMP-3 with IC₅₀s of 0.00065, 1.7, 0.98, 0.39 μM, respectively .

HY-107639

UK-370106	MMP	Inflammation/Immunology
UK-370106 is a potent and highly selective *MMP-3* (IC₅₀ of 23 nM) and *MMP-12* (IC₅₀ of 42 nM) inhibitor with >1200-fold higher potency than MMP-1, MMP-2, MMP-9, and MMP-14, and about 100-fold than MMP-13 and MMP-8. UK-370106 potently inhibits cleavage of [ ³H]-fibronectin by *MMP-3* (IC₅₀ of 320 nM) and has little effect on keratinocyte migration in vitro .

HY-120852

JG26

MMP Cancer

JG26 is an ADAM17 inhibitor, with IC₅₀ values of 12 nM, 1.9 nM, 150 nM and 9.4 nM for ADAM8, ADAM17, ADAM10 and MMP-12, respectively .

JG26	MMP	Cancer
JG26 is an ADAM17 inhibitor, with IC₅₀ values of 12 nM, 1.9 nM, 150 nM and 9.4 nM for ADAM8, ADAM17, ADAM10 and MMP-12, respectively .

HY-156963

Aderamastat FP-025	MMP	Inflammation/Immunology
Aderamastat (FP-025) is an orally active matrix metalloproteinase 12 (MMP-12) inhibitor. Aderamastat can be used for the research of asthma, chronic obstructive pulmonary disease (COPD), and pulmonary fibrosis .

HY-135517

RXP470.1 RXP-470	MMP	Cardiovascular Disease
RXP470.1 (RXP-470) is a potent, selective *MMP-12* inhibitor with a K_i of 0.2 nM against human MMP-12. RXP470.1 is 2 to 4 orders of magnitude less potent against other MMPs. RXP470.1 significantly reduces atherosclerotic plaque cross-sectional area in mouse. RXP470.1 results in less complex plaques with increased smooth muscle cell:macrophage ratio, less macrophage apoptosis, increased cap thickness, smaller necrotic cores, and decreased incidence of calcification .

HY-107013

CP-544439

MMP Inflammation/Immunology

CP-544439 is a potent and orally active matrix metalloproteinase-13 (MMP-13) inhibitor with an IC₅₀ of 0.75 nM .

CP-544439	MMP	Inflammation/Immunology
CP-544439 is a potent and orally active matrix metalloproteinase-13 *(MMP-13)* inhibitor with an IC₅₀ of 0.75 nM .

Cat. No.	Product Name	Target	Research Area

HY-P4521

Ac-Pro-Leu-Gly-[(S)-2-mercapto-4-methyl-pentanoyl]-Leu-Gly-OEt	MMP	Others
Ac-Pro-Leu-Gly-[(S)-2-mercapto-4-methyl-pentanoyl]-Leu-Gly-OEt is a *MMP12* substrate, and can be used to detect MMP12 enzyme activity .

HY-P4905

Mca-Pro-Leu-Gly-Leu-Glu-Glu-Ala-Dap(Dnp)-NH2	Peptides	Cancer
Mca-Pro-Leu-Gly-Leu-Glu-Glu-Ala-Dap(Dnp)-NH2 is highly selective substrate for matrix metalloproteases 12 (MMP12) substrate with a kcat/Km value of 1.8510 ⁵ M ^-1s ^-1, and poor substrate of other MMPs with the exception of MMP13* (kcat/Km = 0.5310 ⁵ M ^-1s ^-1) and MMP9* (0.33*10 ⁵ M ^-1s ^-1) .

Recombinant Proteins Recommended:

MMP-12

Species:	Human (1) Mouse (1)
Tag:	His (1) Tag Free (1)
Source:	HEK293 (1) E. coli (1)

Cat. No.	Compare	Product Name	Species	Source

HY-P74744

	MMP-12 Protein, Human Macrophage metalloelastase; MME; MMP-12; HME	Human	E. coli
	MMP-12 protein is potentially engaged in tissue injury and remodeling, displaying significant elastolytic activity. It shows flexibility at the P1' site, accommodating both large and small amino acids, yet favoring leucine. At the P1 site, it prefers aromatic or hydrophobic residues, with a tendency for small hydrophobic residues like alanine in the P3 position. MMP-12 Protein, Human is the recombinant human-derived MMP-12 protein, expressed by E. coli , with tag free. The total length of MMP-12 Protein, Human is 163 a.a., with molecular weight of ~18 kDa.

HY-P70342

	MMP-12 Protein, Mouse (HEK293, His) rMuMacrophage metalloelastase/MMP12, His; Macrophage metalloelastase; MME; Matrix metalloproteinase-12; MMP-12; MMP12; Mme; Mmel	Mouse	HEK293
	MMP-12 protein has significant elastolytic activity and may contribute to tissue damage and remodeling. Its substrate preferences include preference for leucine at the P1' site and aromatic/hydrophobic residues at the P1 site, and preference for small hydrophobic residues such as alanine at the P3 site. MMP-12 Protein, Mouse (HEK293, His) is the recombinant mouse-derived MMP-12 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of MMP-12 Protein, Mouse (HEK293, His) is 445 a.a., with molecular weight of ~64.0 kDa.


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Cat. No.	Product Name	Application	Reactivity

HY-P80755

MMP12 Antibody Macrophage metalloelastase; MME; 3.4.24.65; Macrophage elastase; ME; hME; Matrix metalloproteinase-12; MMP-12; MMP12; HME	WB, IP	Human, Rat, Hamster
MMP12 Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 54 kDa, targeting to MMP12. It can be used for WB,IP assays with tag free, in the background of Human, Rat, Hamster.

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