MMP9

Isoforms Recommended:	MMP-9

By Targets:	Akt (7) Aminopeptidase (1) Angiotensin-converting Enzyme (ACE) (2) Antibiotic (2) Apoptosis (17) Autophagy (3) Bacterial (2) Bcl-2 Family (1) Caspase (1) Cathepsin (2) Chloride Channel (1) COX (3) EGFR (1) ERK (2) FAK (2) Fluorescent Dye (1) HSV (1) Interleukin Related (1) JNK (1) Microtubule/Tubulin (1) MMP (82) mTOR (3) NF-κB (6) NO Synthase (1) P-glycoprotein (1) p38 MAPK (2) PARP (1) PI3K (2) Proteasome (1) Reactive Oxygen Species (3) Small Interfering RNA (siRNA) (3) Src (1) TNF Receptor (1) Toll-like Receptor (TLR) (1)
By Research Areas:	Cancer (60) Cardiovascular Disease (9) Infection (4) Inflammation/Immunology (23) Metabolic Disease (5) Neurological Disease (5)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-135232

MMP-9-IN-1 5 Publications Verification	MMP	Cancer
MMP-9-IN-1 is a specific matrix metalloproteinase-9 (MMP-9) inhibitor, which selectively target the hemopexin (PEX) domain of MMP-9, but not other MMPs .

HY-RS08557

MMP9 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
MMP9 Human Pre-designed siRNA Set A contains three designed siRNAs for MMP9 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

MMP9 Human Pre-designed siRNA Set A MMP9 Human Pre-designed siRNA Set A

HY-RS08558

Mmp9 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Mmp9 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Mmp9 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Mmp9 Mouse Pre-designed siRNA Set A Mmp9 Mouse Pre-designed siRNA Set A

HY-RS08559

Mmp9 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Mmp9 Rat Pre-designed siRNA Set A contains three designed siRNAs for Mmp9 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Mmp9 Rat Pre-designed siRNA Set A Mmp9 Rat Pre-designed siRNA Set A

HY-153913

MMP-9-IN-7	MMP	Inflammation/Immunology
MMP-9-IN-7 is a potent *MMP9* inhibitor with an IC₅₀ of 0.52 μM in proMMP9/MMP3 P126 activation assay. MMP-9-IN-7 is extracted from patent WO2012162468 (example 59), and can be used for MMP9/MMP13 mediated syndrome research .

HY-116302

MMP-9-IN-9	MMP	Neurological Disease Inflammation/Immunology
MMP-9-IN-9 (compound 4f) is a slective *MMP-9* inhibitor with an IC₅₀ of 5 nM. MMP-9-IN-9 shows selective for MMP-9 over MMP-1 and MMP-13. MMP-9-IN-9 shows strong anti-inflammatory and neuroprotective effects .

HY-146218

MMP-9-IN-5	MMP Akt Apoptosis	Cancer
MMP-9-IN-5 is a *MMP-9* inhibitor (IC₅₀: 4.49 nM) that forms hydrogen bond with MMP-9. MMP-9-IN-5 also inhibits _AKT activity (IC₅₀: 1.34 nM). MMP-9-IN-5 shows cell cytotoxicity and induces cell apoptosis. MMP-9-IN-5 can be used in the research of cancers .

HY-146216

MMP-9-IN-3	MMP Akt Apoptosis	Cancer
MMP-9-IN-3 is a *MMP-9* inhibitor (IC₅₀: 5.56 nM) that forms hydrogen bond with MMP-9. MMP-9-IN-3 also inhibits AKT activity (IC₅₀: 2.11 nM). MMP-9-IN-3 shows cell cytotoxicity and induces cell apoptosis. MMP-9-IN-3 can be used in the research of cancers .

HY-146217

MMP-9-IN-4	MMP Akt Apoptosis	Cancer
MMP-9-IN-4 is a *MMP-9* inhibitor (IC₅₀: 7.46 nM) that has H-π interactions with MMP-9. MMP-9-IN-4 also inhibits _AKT activity (IC₅₀: 8.82 nM). MMP-9-IN-4 shows cell cytotoxicity and induces cell apoptosis. MMP-9-IN-4 can be used in the research of cancers .

HY-149848

MMP-9-IN-6

MMP Inflammation/Immunology

MMP-9-IN-6 (Compound 3g) is a MMP-9 inhibitor with IC₅₀ value of 50 μM, which has good anti-ulcer effect .

MMP-9-IN-6	MMP	Inflammation/Immunology
MMP-9-IN-6 (Compound 3g) is a *MMP-9* inhibitor with IC₅₀ value of 50 μM, which has good anti-ulcer effect .

HY-161285

MMP-9/10-IN-2	MMP	Cancer
MMP-9/10-IN-2 (compound 6e) is a potent inhibitor of *MMP10 and MMP9, with IC₅₀* of 0.076 μM for *MMP*10, and 93.18% inhibition at 0.5 μM for *MMP9. MMP-9*/10-IN-2 plays an important role in anti-tumor .

HY-157138

MMP-9-IN-8	Others	Cancer
MMP-9-IN-8 (Compound 3) is an MMP-9 inhibitor with inhibitory activities of 42.16% and 58.28% at 10 μM and 50 μM concentrations, respectively. MMP-9-IN-8 has anti-cancer activity and can induce apoptosis in MCF-7 cells with an IC₅₀ value of 23.42 μM .

HY-128026

MMP-9/MMP-13 Inhibitor I	MMP	Inflammation/Immunology
MMP-9/MMP-13 Inhibitor I is a potent *MMP-9* and *MMP-13* inhibitor with IC₅₀s of both 0.9 nM. MMP-9/MMP-13 Inhibitor I shows >20-folds selectivity for MMP-9/MMP-13 over other MMPs .

HY-161284

MMP-9/10-IN-1	MMP	Cancer
MMP-9/10-IN-1 (Compound 6b) is a potent dual *MMP-9/10* Inhibotor with IC₅₀s of 0.076 and 0.139 μM against NSCLC and A549 cells, respectively. MMP-9/10-IN-1 has anti-invasive and anti-angiogenic activities when in combination with Sorafenib (HY-10201) .

HY-P2179

MMP-1/MMP-9 Substrate, Fluorogenic

Fluorescent Dye MMP Others

MMP-1/MMP-9 Substrate, Fluorogenic is a fluorogenic substrate for MMP-1 and MMP-9 .Ex/Em = 340/440 nm

MMP-1/MMP-9 Substrate, Fluorogenic	Fluorescent Dye MMP	Others
MMP-1/MMP-9 Substrate, Fluorogenic is a fluorogenic substrate for MMP-1 and MMP-9 .Ex/Em = 340/440 nm

HY-116399

MMP-2/MMP-9-IN-1	MMP	Cancer
MMP-2/MMP-9-IN-1 is a highly selective, orally active and potent type IV collagenase (MMP-9 and *MMP-2) inhibitor with IC₅₀s of 0.24 and 0.31 μM for MMP-9* and MMP-2, respectively. MMP-2/MMP-9-IN-1 is orally active in animal models of tumor growth and metastasis. MMP-2/MMP-9-IN-1 can be used for the research of cancer .

HY-P1789

CTTHWGFTLC, CYCLIC	MMP	Inflammation/Immunology Cancer
CTTHWGFTLC, CYCLIC is a cyclic peptide inhibitor for matrix metalloproteinases MMP-2 and *MMP-9. The IC₅₀* value for MMP-9 is ~8 μM .

HY-P1789A

CTTHWGFTLC, CYCLIC TFA	MMP	Inflammation/Immunology Cancer
CTTHWGFTLC, CYCLIC TFA is a cyclic peptide inhibitor for matrix metalloproteinases MMP-2 and *MMP-9. The IC₅₀* value for MMP-9 is ~8 μM .

HY-P99351

Andecaliximab Anti-MMP9 Reference Antibody (andecaliximab)	MMP	Cancer
Andecaliximab is a recombinant chimeric IgG4 monoclonal antibody (mAb) targets matrix metalloproteinase 9 (MMP9). Andecaliximab shows the antifibrotic efficacy in idiopathic pulmonary fibrosis mouse models. Andecaliximab can be used for the research of gastric adenocarcinoma and idiopathic pulmonary fibrosis (IPF) .

HY-103482

JNJ0966

5+ Cited Publications

MMP Cancer

JNJ0966 is a highly selective MMP-9 zymogen inhibitor with an IC₅₀ of 440 nM.

JNJ0966 5+ Cited Publications	MMP	Cancer
JNJ0966 is a highly selective MMP-9 zymogen inhibitor with an IC₅₀ of 440 nM.

HY-N0318

Salvianolic acid A 1 Publications Verification	MMP	Inflammation/Immunology
Salvianolic acid A could protect the blood brain barrier through matrix metallopeptidase 9 (MMP-9) inhibition and anti-inflammation.

HY-155960

SH491	Others	Inflammation/Immunology
SH491 (Compound 33) is an antiosteoporosis agent. SH491 inhibits RANKL-induced osteoclast differentiation on bone-marrow-derived monocytes (BMMs) (IC₅₀: 11.8 nM). SH491 inhibits the expression of osteoclastogenesis-related marker genes (TRAP, CTSK, MMP-9, and ATPase v0d2) and proteins (TRAP, CTSK, MMP-9) .

HY-N6862

Lucideric acid A	MMP	Cancer
Lucideric acid A is a natural compound isolated from Ganoderma lucidum, inhibits PMA-induced *MMP-9* activity, with anti-invasive effect on hepatoma cells .

HY-N6860

Lucidenic acid C	MMP	Cancer
Lucidenic acid C is a natural compound isolated from Ganoderma lucidum, inhibits PMA-induced *MMP-9* activity, with anti-invasive effect on hepatoma cells .

HY-12170

Prinomastat 2 Publications Verification AG3340; KB-R9896	MMP Apoptosis	Cancer
Prinomastat (AG3340) is a broad spectrum, potent, orally active metalloproteinase (MMP) inhibitor with IC₅₀s of 79, 6.3 and 5.0 nM for *MMP-1, MMP-3* and *MMP-9, respectively. Prinomastat inhibits MMP-2, MMP-3* and *MMP-9* with K_is of 0.05 nM, 0.3 nM and 0.26 nM, respectively. Prinomastat crosses blood-brain barrier. Antitumor avtivity .

HY-P0273

Histatin 5

MMP Inflammation/Immunology

Histatin 5 inhibits the activity of the host matrix metalloproteinases MMP-2 and MMP-9 with IC₅₀s of 0.57 and 0.25 μM, respectively.

Histatin 5	MMP	Inflammation/Immunology
Histatin 5 inhibits the activity of the host matrix metalloproteinases *MMP-2* and *MMP-9* with IC₅₀s of 0.57 and 0.25 μM, respectively.

HY-N10176

D-Isofloridoside	Reactive Oxygen Species MMP	Cardiovascular Disease
D-Isofloridoside, one of the polysaccharide precursors, has the activity of scavenging free radicals, inhibiting ROS expression, and inhibiting MMP-2 and MMP-9 .

HY-P0273A

Histatin 5 TFA

MMP Inflammation/Immunology

Histatin 5 TFA inhibits the activity of the host matrix metalloproteinases MMP-2 and MMP-9 with IC₅₀s of 0.57 and 0.25 μM, respectively.

Histatin 5 TFA	MMP	Inflammation/Immunology
Histatin 5 TFA inhibits the activity of the host matrix metalloproteinases *MMP-2* and *MMP-9* with IC₅₀s of 0.57 and 0.25 μM, respectively.

HY-12170A

Prinomastat hydrochloride 2 Publications Verification AG3340 hydrochloride; KB-R9896 hydrochloride	MMP Apoptosis	Cancer
Prinomastat hydrochloride (AG3340 hydrochloride) is a broad spectrum, potent, orally active metalloproteinase (MMP) inhibitor with IC₅₀s of 79, 6.3 and 5.0 nM for *MMP-1, MMP-3* and *MMP-9, respectively. Prinomastat hydrochloride inhibits MMP-2, MMP-3* and *MMP-9* with K_is of 0.05 nM, 0.3 nM and 0.26 nM, respectively. Prinomastat hydrochloride can cross blood-brain barrier. Antitumor avtivity .

HY-P4574

VPLSLYSG

MMP Others

VPLSLYSG is an octapeptide that can be degraded by matrix metalloproteinase-9 (MMP-9), MMP-1 and MMP-2. VPLSLYSG has potential applications in MMP substrates .
HY-162038

RXP03

MMP Others

RXP03 is a MMPs inhibitor with the K_i of 20 nM, 2.5 nM, 10 nM, 5nM and 105 nM for MMP-2, MMP-8, MMP-9, MMP-11, MMP-14, respectively .
HY-19956

GI254023X

5+ Cited Publications

GI4023; SRI028594
MMP Cancer

GI254023X is a potent MMP9 and ADAM10 inhibitor with IC₅₀s of 2.5 and 5.3 nM, respectively.

VPLSLYSG	MMP	Others
VPLSLYSG is an octapeptide that can be degraded by matrix metalloproteinase-9 (MMP-9), *MMP-1* and *MMP-2. VPLSLYSG has potential applications in MMP* substrates .

RXP03	MMP	Others
RXP03 is a *MMPs* inhibitor with the K_i of 20 nM, 2.5 nM, 10 nM, 5nM and 105 nM for MMP-2, MMP-8, MMP-9, MMP-11, MMP-14, respectively .

GI254023X 5+ Cited Publications GI4023; SRI028594	MMP	Cancer
GI254023X is a potent *MMP9* and ADAM10 inhibitor with IC₅₀s of 2.5 and 5.3 nM, respectively.

HY-13564

Batimastat 5+ Cited Publications BB94	MMP	Cancer
Batimastat is a potent broad spectrum *MMP* inhibitor with IC₅₀ of 3, 4, 4, 6, and 20 nM for *MMP-1, MMP-2, MMP-9, MMP-7* and *MMP-3*, respectively.

HY-13564A

Batimastat sodium salt BB-94 sodium salt	MMP	Cancer
Batimastat sodium salt is a potent broad spectrum *MMP* inhibitor with IC₅₀ of 3, 4, 4, 6, and 20 nM for *MMP-1, MMP-2, MMP-9, MMP-7* and *MMP-3*, respectively.

HY-N2117

Isoginkgetin 10+ Cited Publications	MMP Akt NF-κB Proteasome Apoptosis Autophagy	Inflammation/Immunology Cancer
Isoginkgetin is a pre-mRNA splicing inhibitor inhibitor. Isoginkgetin also inhibits activities of both Akt, NF-κB and *MMP-9. Isoginkgetin inhibits the activity of the 20S proteasome, induces apoptosis* and activates autophagy .

HY-E70005C

Collagenase, Type III	MMP	Others
Collagenase, Type III is a microbially derived matrix metalloproteinases (MMPs) and zinc peptidase. Collagenase, Type III breaksdown collagens1, 4, 9, 10, 14, fibronectin, MMP-9, gelatin, plasminogen, aggrecan,perlecan osteonectin

HY-N0431

Astragaloside IV 5+ Cited Publications	MMP ERK JNK	Cancer
Astragaloside IV, an active component isolated from Astragalus membranaceus, suppresses the activation of ERK1/2 and JNK, and downregulates matrix metalloproteases (MMP)-2, (MMP)-9 in MDA-MB-231 breast cancer cells.

HY-W277900

2-Methoxy-2,4-diphenylfuran-3-one	MMP	Inflammation/Immunology Cancer
2-Methoxy-2,4-diphenylfuran-3-one is a fluorescent compound which can be used to label gelatin as a substrate for detection of the gelatin degrading *MMP-2* and *MMP-9* by zymography .

HY-N3063

Pimaric acid	Others	Cardiovascular Disease
Pimaric acid is a resin acid that has been found in A. cordata and various pines. Pimaric acid reduces mRNA expression, protein levels, and promoter activity of matrix metalloproteinase-9 (MMP-9) in TNF-α-stimulated human aortic smooth muscle cells (HASMCs).

HY-110046

CL-82198 hydrochloride	MMP	Others
CL-82198 hydrochloride is a selective inhibitor of *MMP-13. CL-82198 hydrochloride binds to the entire S1’ pocket of MMP-13, which is the basis of its selectivity against MMP-1, MMP-9*, and TACE .

HY-P2004

FFAGLDD	MMP	Cancer
FFAGLDD is *MMP9* selective cleavage peptides, which used for cytosolic delivery of Doxorubi-cin (DOX) and achieve temporally and spatially controlled slow drug delivery and release .

HY-106992

S 3304	MMP	Cancer
S 3304 is a novel matrix metalloproteinases (MMP) inhibitor specific for *MMP-2* and *MMP-9*. S 3304 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-119423

MMP Inhibitor II	MMP	Cancer
MMP Inhibitor II (compound 4e) is a potent, reversible pan-MMP inhibitor with IC₅₀ values of 24 nM, 18.4 nM, 30 nM, and 2.7 nM for MMP-1,MMP-3, MMP-7, and MMP-9, respectively .

HY-W011085

CP-471474	MMP	Inflammation/Immunology
CP-471474 is an orally active and pan *MMP* inhibitor, with IC₅₀ values of 1170 nM (MMP-1), 0.7 nM (MMP-2), 16 nM (MMP-3), 13 nM (MMP-9) and 0.9 nM (MMP-13), respectively .

HY-P3484

Dnp-PLGLWA-DArg-NH2 TFA	MMP	Cancer
Dnp-PLGLWA-DArg-NH2 TFA is a fluorogenic substrate for MMP-1 and MMP-9. Dnp-PLGLWA-DArg-NH2 TFA can be used to quantify the activity of MMPs (Ex=280 nm, Em=360 nm) .

HY-P3513

β-Neo-Endorphin	ERK MMP	Neurological Disease
β-Neo-Endorphin is an endogenous opioid peptide. β-Neo-Endorphin is a hypothalamic “big” Leu-enkephalin of porcine origin. β-Neo-Endorphin shows activation of the Erk1/2, *MMP-2* and *MMP-9* .

HY-114396

BR351

MMP Cancer

BR351 is a brain penetrant MMP inhibitor with IC₅₀s of 4, 2, 11, 50 nM for MMP2, MMP8, MMP9 and MMP13, respectively .

HY-P2004A

FFAGLDD TFA	MMP	Cancer
FFAGLDD TFA is *MMP9* selective cleavage peptides, which used for cytosolic delivery of Doxorubi-cin (DOX) and achieve temporally and spatially controlled slow drug delivery and release .

HY-N1454

Apigenin-7-glucuronide 1 Publications Verification Apigenin 7-O-glucuronide
Apigenin-7-glucuronide could inhibit Matrix Metalloproteinases *(MMP)* activities, with IC₅₀s of 12.87, 22.39, 17.52, 0.27 μM for MMP-3, MMP-8, MMP-9, MMP-13, respectively.

HY-136699

Excisanin A	Others	Cancer
Excisanin A is a potent anticancer agent. Excisanin A inhibits cell proliferation, migration, adhesion and invasion. Excisanin A decreases the expression of MMP-2, MMP-9, p-FAK, p-Src, integrin β1 protein. Excisanin A has the potential for the research of breast cancer .

Cat. No.	Product Name	Type

HY-W277900

2-Methoxy-2,4-diphenylfuran-3-one	Fluorescent Dyes/Probes
2-Methoxy-2,4-diphenylfuran-3-one is a fluorescent compound which can be used to label gelatin as a substrate for detection of the gelatin degrading *MMP-2* and *MMP-9* by zymography .

HY-P3484

Dnp-PLGLWA-DArg-NH2 TFA	Fluorescent Dyes/Probes
Dnp-PLGLWA-DArg-NH2 TFA is a fluorogenic substrate for MMP-1 and MMP-9. Dnp-PLGLWA-DArg-NH2 TFA can be used to quantify the activity of MMPs (Ex=280 nm, Em=360 nm) .

Cat. No.	Product Name	Type

HY-W016412

Coenzyme Q0

2 Publications Verification

CoQ0

Biochemical Assay Reagents

Coenzyme Q0 (CoQ0) is a potent, oral active ubiquinone compound can be derived from Antrodia cinnamomea. Coenzyme Q0 induces apoptosis and autophagy, suppresses of HER-2/AKT/mTOR signaling to potentiate the apoptosis and autophagy mechanisms. Coenzyme Q0 regulates NFκB/AP-1 activation and enhances Nrf2 stabilization in attenuation of inflammation and redox imbalance. Coenzyme Q0 has anti-angiogenic activity through downregulation of MMP-9/NF-κB and upregulation of HO-1 signaling .

Cat. No.	Product Name	Target	Research Area

HY-P1789A

CTTHWGFTLC, CYCLIC TFA	MMP	Inflammation/Immunology Cancer
CTTHWGFTLC, CYCLIC TFA is a cyclic peptide inhibitor for matrix metalloproteinases MMP-2 and *MMP-9. The IC₅₀* value for MMP-9 is ~8 μM .

HY-P2179

MMP-1/MMP-9 Substrate, Fluorogenic

Fluorescent Dye MMP Others

MMP-1/MMP-9 Substrate, Fluorogenic is a fluorogenic substrate for MMP-1 and MMP-9 .Ex/Em = 340/440 nm

HY-P1789

CTTHWGFTLC, CYCLIC	MMP	Inflammation/Immunology Cancer
CTTHWGFTLC, CYCLIC is a cyclic peptide inhibitor for matrix metalloproteinases MMP-2 and *MMP-9. The IC₅₀* value for MMP-9 is ~8 μM .

HY-P2689

DNP-PLGMWSR

Peptides Others

DNP-PLGMWSR is a? fluorogenic substrate for MMP-2 and MMP-9 .
HY-P0273

Histatin 5

MMP Inflammation/Immunology

Histatin 5 inhibits the activity of the host matrix metalloproteinases MMP-2 and MMP-9 with IC₅₀s of 0.57 and 0.25 μM, respectively.
HY-P0273A

Histatin 5 TFA

MMP Inflammation/Immunology

Histatin 5 TFA inhibits the activity of the host matrix metalloproteinases MMP-2 and MMP-9 with IC₅₀s of 0.57 and 0.25 μM, respectively.
HY-P4574

VPLSLYSG

MMP Others

VPLSLYSG is an octapeptide that can be degraded by matrix metalloproteinase-9 (MMP-9), MMP-1 and MMP-2. VPLSLYSG has potential applications in MMP substrates .

HY-P2004

FFAGLDD	MMP	Cancer
FFAGLDD is *MMP9* selective cleavage peptides, which used for cytosolic delivery of Doxorubi-cin (DOX) and achieve temporally and spatially controlled slow drug delivery and release .

HY-P3484

Dnp-PLGLWA-DArg-NH2 TFA	MMP	Cancer
Dnp-PLGLWA-DArg-NH2 TFA is a fluorogenic substrate for MMP-1 and MMP-9. Dnp-PLGLWA-DArg-NH2 TFA can be used to quantify the activity of MMPs (Ex=280 nm, Em=360 nm) .

HY-P3513

β-Neo-Endorphin	ERK MMP	Neurological Disease
β-Neo-Endorphin is an endogenous opioid peptide. β-Neo-Endorphin is a hypothalamic “big” Leu-enkephalin of porcine origin. β-Neo-Endorphin shows activation of the Erk1/2, *MMP-2* and *MMP-9* .

HY-P2004A

FFAGLDD TFA	MMP	Cancer
FFAGLDD TFA is *MMP9* selective cleavage peptides, which used for cytosolic delivery of Doxorubi-cin (DOX) and achieve temporally and spatially controlled slow drug delivery and release .

HY-P2036A

FSL-1 TFA 3 Publications Verification	Toll-like Receptor (TLR) MMP HSV Antibiotic	Infection
FSL-1 TFA, a bacterial-derived toll-like receptor 2/6 (TLR2/6) agonist, enhances resistance to experimental HSV-2 infection . FSL-1 TFA induces *MMP-9* production through TLR2 and NF-κB/AP-1 signaling pathways in monocytic THP-1 cells .

HY-P4373

Hepcidin-1 (mouse)	Cathepsin MMP	Metabolic Disease
Hepcidin-1 (mouse) is an endogenous peptide hormone involved in the regulation of iron homeostasis. Hepcidin-1 (mouse) upregulates mRNA levels of TRAP, cathepsin K, and MMP-9 and increases TRAP-5b protein secretion. Hepcidin-1 (mouse) downregulates the level of FPN1 protein and increases intracellular iron. Hepcidin-1 (mouse) facilitates osteoclast differentiation .

HY-P10143

MMP-2/MMP-9 Substrate

Peptides Others

MMP-2/MMP-9 Substrate, a synthetic colorimetric substrate, is a peptide .

HY-P4373A

Hepcidin-1 (mouse) (TFA)	Cathepsin MMP	Inflammation/Immunology
Hepcidin-1 (mouse) TFA is an endogenous peptide hormone involved in the regulation of iron homeostasis. Hepcidin-1 (mouse) TFA upregulates mRNA levels of TRAP, cathepsin K, and *MMP-9* and increases TRAP-5b protein secretion. Hepcidin-1 (mouse) TFA downregulates the level of FPN1 protein and increases intracellular iron. Hepcidin-1 (mouse) TFA facilitates osteoclast differentiation .

HY-P4905

Mca-Pro-Leu-Gly-Leu-Glu-Glu-Ala-Dap(Dnp)-NH2	Peptides	Cancer
Mca-Pro-Leu-Gly-Leu-Glu-Glu-Ala-Dap(Dnp)-NH2 is highly selective substrate for matrix metalloproteases 12 (MMP12) substrate with a kcat/Km value of 1.8510 ⁵ M ^-1s ^-1, and poor substrate of other MMPs with the exception of MMP13* (kcat/Km = 0.5310 ⁵ M ^-1s ^-1) and MMP9* (0.33*10 ⁵ M ^-1s ^-1) .

Cat. No.	Product Name	Target	Research Area

HY-P99351

Andecaliximab Anti-MMP9 Reference Antibody (andecaliximab)	MMP	Cancer
Andecaliximab is a recombinant chimeric IgG4 monoclonal antibody (mAb) targets matrix metalloproteinase 9 (MMP9). Andecaliximab shows the antifibrotic efficacy in idiopathic pulmonary fibrosis mouse models. Andecaliximab can be used for the research of gastric adenocarcinoma and idiopathic pulmonary fibrosis (IPF) .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0318

Salvianolic acid A 1 Publications Verification	Structural Classification Stilbenes Classification of Application Fields Labiatae Source classification Samanea saman (Jacq.) Merr. Phenols Polyphenols Plants Inflammation/Immunology Disease Research Fields	MMP
Salvianolic acid A could protect the blood brain barrier through matrix metallopeptidase 9 (MMP-9) inhibition and anti-inflammation.

HY-N6862

Lucideric acid A	Triterpenes Classification of Application Fields Terpenoids Source classification Polyporaceae Plants Disease Research Fields Cancer	MMP
Lucideric acid A is a natural compound isolated from Ganoderma lucidum, inhibits PMA-induced *MMP-9* activity, with anti-invasive effect on hepatoma cells .

HY-N2117

Isoginkgetin Maximum Cited Publications 12 Publications Verification	Structural Classification Flavonoids Ginkgoaceae Classification of Application Fields Source classification Phenols Polyphenols Plants Biflavones Ginkgo biloba Disease Research Fields Cancer	MMP Akt NF-κB Proteasome Apoptosis Autophagy
Isoginkgetin is a pre-mRNA splicing inhibitor inhibitor. Isoginkgetin also inhibits activities of both Akt, NF-κB and *MMP-9. Isoginkgetin inhibits the activity of the 20S proteasome, induces apoptosis* and activates autophagy .

HY-N6860

Lucidenic acid C	Triterpenes Microorganisms Classification of Application Fields Terpenoids Source classification Polyporaceae Plants Disease Research Fields Cancer	MMP
Lucidenic acid C is a natural compound isolated from Ganoderma lucidum, inhibits PMA-induced *MMP-9* activity, with anti-invasive effect on hepatoma cells .

HY-N10176

D-Isofloridoside	Cardiovascular Disease other families Classification of Application Fields Source classification Plants Disease Research Fields Saccharides	Reactive Oxygen Species MMP
D-Isofloridoside, one of the polysaccharide precursors, has the activity of scavenging free radicals, inhibiting ROS expression, and inhibiting MMP-2 and MMP-9 .

HY-N0431

Astragaloside IV 5+ Cited Publications	Triterpenes Structural Classification Classification of Application Fields Leguminosae Terpenoids Source classification Astragalus membranaceus var. mongholicus (Bunge)P.K.Hsiao Plants Disease Research Fields Cancer	MMP ERK JNK
Astragaloside IV, an active component isolated from Astragalus membranaceus, suppresses the activation of ERK1/2 and JNK, and downregulates matrix metalloproteases (MMP)-2, (MMP)-9 in MDA-MB-231 breast cancer cells.

HY-136699

Excisanin A	Structural Classification Terpenoids Labiatae Source classification Diterpenoids Plants Baccharis densiflora Wedd.	Others
Excisanin A is a potent anticancer agent. Excisanin A inhibits cell proliferation, migration, adhesion and invasion. Excisanin A decreases the expression of MMP-2, MMP-9, p-FAK, p-Src, integrin β1 protein. Excisanin A has the potential for the research of breast cancer .

HY-N7385

Nudol	Orchidaceae Source classification Phenols Polyphenols Plants Epigeneium rotundatum (Lindl.) Summerh.	MMP Apoptosis
Nudol is a phenanthrene compound that has anti-cancer activity. Nudol inhibits cell proliferation, induces cell apoptosis. Nudol inhibits *MMP-2M* and *MMP-9* activity (K_i: 988.9 nM, 1.76 μM, respectively). Nudol can be used in the research of cancers, such as osteosarcoma .

HY-N0069

Solamargine 10+ Cited Publications Solamargin; δ-Solanigrine	Structural Classification Alkaloids Piperidine Alkaloids Solanum Classification of Application Fields Plants Solanaceae Disease Research Fields Saccharides Steroids Cancer	P-glycoprotein Apoptosis
Solamargine, a derivative from the steroidal solasodine in Solanum species, exhibits anticancer activities in numerous types of cancer. Solamargine induces non-selective cytotoxicity and P-glycoprotein inhibition. Solamargine significantly inhibits migration and invasion of HepG2 cells by down-regulating MMP-2 and MMP-9 expression and activity .

HY-N2497

Isoliquiritin apioside 1 Publications Verification	Flavonoids Chalcones other families Classification of Application Fields Source classification Phenols Polyphenols Plants Disease Research Fields Cancer	NF-κB MMP p38 MAPK
Isoliquiritin apioside significantly decreases PMA-induced increases in *MMP9* activities and suppresses PMA-induced activation of MAPK and NF-κB. Isoliquiritin apioside auppresseses invasiveness and angiogenesis of cancer cells and endothelial cells .

HY-N5136

25(R,S)-Ruscogenin	Liliaceae Microorganisms Classification of Application Fields Source classification Liriope platyphylla Wang et Tang Plants Disease Research Fields Steroids Cancer	Apoptosis PI3K Akt mTOR
Ruscogenin suppresses HCC metastasis by reducing the expression of MMP-2, MMP-9, uPA, VEGF and HIF-1α via regulating the PI3K/Akt/mTOR signaling pathway . And Ruscogenin alleviates LPS-induced pulmonary endothelial cell apoptosis by su

HY-N0084

Betulinaldehyde 4 Publications Verification Betulinic aldehyde; Betunal	Triterpenes Structural Classification other families Classification of Application Fields Terpenoids Source classification Plants Disease Research Fields Cancer	Bacterial
Betulinaldehyde (Betunal) Has anti-cancer and anti-staphylococcus aureus activity. Betulinaldehyde Suppressible Akt, MAPK sum STAT3 Signal path, increase self-transfer, Suppression A549 Cellular vitality, increase and transfer. Betulinaldehyde suppresses PLCγ1/Ca ²⁺/MMP9 signal pathway, has a key effect on vascular plasticity, and is available for cardiovascular disease (CVD) research.

HY-113952

Actinonin 4 Publications Verification (-)-Actinonin	Infection Structural Classification Natural Products Microorganisms Classification of Application Fields Source classification Disease Research Fields	Aminopeptidase Bacterial MMP Apoptosis Antibiotic
Actinonin ((-)-Actinonin) is a naturally occurring antibacterial agent produced by Actinomyces. Actinonin inhibits aminopeptidase M, aminopeptidase N and leucine aminopeptidase. Actinonin is a potent reversible peptide deformylase (PDF) inhibitor with a K_i of 0.28 nM. Actinonin also inhibits *MMP-1, MMP-3, MMP-8, MMP-9, and hmeprin α* with K_i values of 300 nM, 1,700 nM, 190 nM, 330 nM, and 20 nM, respectively. Actinonin is an apoptosis inducer. Actinonin has antiproliferative and antitumor activities .

Recombinant Proteins Recommended:

MMP-9

Species:	Human (7) Mouse (3) Rat (1) Cynomolgus (1)
Tag:	His (10) Tag Free (2) Avi (2)
Source:	HEK293 (11) P. pastoris (1)

Cat. No.	Compare	Product Name	Species	Source

HY-P70145

	MMP-9 Protein, Human (HEK293, His) rHuMatrix metalloproteinase-9/MMP-9, His; Matrix metalloproteinase-9; 92 kDa gelatinase; 92 kDa type IV collagenase; Gelatinase B; MMP9	Human	HEK293
	The MMP-9 protein is a matrix metalloproteinase that is critical for local extracellular matrix proteolysis and leukocyte migration. It is suggested that it may be involved in bone osteoclastic resorption. MMP-9 Protein, Human (HEK293, His) is the recombinant human-derived MMP-9 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of MMP-9 Protein, Human (HEK293, His) is 689 a.a., with molecular weight of ~90.0 kDa.

HY-P73300

	MMP-9 Protein, Human (HEK293) Matrix metalloproteinase-9; MMP-9; Gelatinase B; GELB; CLG4B	Human	HEK293
	MMP-9 is an important member of the MMP protein family and regulates the extracellular matrix during physiological processes such as development and tissue remodeling. It involves arthritis and metastasis. MMP-9 Protein, Human (HEK293) is the recombinant human-derived MMP-9 protein, expressed by HEK293 , with tag free. The total length of MMP-9 Protein, Human (HEK293) is 688 a.a., with molecular weight of 80-95 kDa.

HY-P73807

	MMP-9 Protein, Mouse (HEK293) Matrix metalloproteinase-9; MMP-9; Gelatinase B; GELB; CLG4B	Mouse	HEK293
	The MMP-9 protein is a matrix metalloproteinase that is critical for local extracellular matrix proteolysis and leukocyte migration. It is suggested that it may be involved in bone osteoclastic resorption. MMP-9 Protein, Mouse (HEK293) is the recombinant mouse-derived MMP-9 protein, expressed by HEK293 , with tag free. The total length of MMP-9 Protein, Mouse (HEK293) is 710 a.a., with molecular weight of ~100 kDa.

HY-P73301

	MMP-9 Protein, Rat (HEK293, His) Matrix metalloproteinase-9; MMP-9; Gelatinase B; GELB; CLG4B	Rat	HEK293
	Matrix metalloproteinase-9 (Mmp9) is a member of the matrix metalloproteinase (MMP) family. Mmp9 is secreted as inactive proproteins which are activated when cleaved by extracellular proteinases to generate a mature, zinc-dependent endopeptidase enzyme that degrades collagens of type IV, V and XI, and elastin. Mmp9 is also involved in IL-8-induced mobilization of hematopoietic progenitor cells from bone marrow. MMP-9 Protein, Rat (HEK293, His) is the recombinant rat-derived MMP-9 protein, expressed by HEK293 , with C-10*His labeled tag. The total length of MMP-9 Protein, Rat (HEK293, His) is 689 a.a., with molecular weight of approximately 95 kDa.

HY-P70351

	MMP-9 Protein, Mouse (HEK293, His) rMuMatrix metalloproteinase-9/MMP-9, His; Matrix metalloproteinase-9; MMP-9; 92 kDa gelatinase; 92 kDa type IV collagenase; Gelatinase B; GELB	Mouse	HEK293
	The MMP-9 protein is a matrix metalloproteinase that is critical for local extracellular matrix proteolysis and leukocyte migration. It is suggested that it may be involved in bone osteoclastic resorption. MMP-9 Protein, Mouse (HEK293, His) is the recombinant mouse-derived MMP-9 protein, expressed by HEK293 , with C-10*His labeled tag. The total length of MMP-9 Protein, Mouse (HEK293, His) is 711 a.a., with molecular weight of ~100.0 kDa.

HY-P700893

	MMP-9 Protein, Cynomolgus (HEK293, His) MMP-9; GELB; CLG4B; MANDP2; Gelatinase B	Cynomolgus	HEK293
	The MMP-9 protein is a matrix metalloproteinase that is critical for local extracellular matrix proteolysis and leukocyte migration. It is suggested that it may be involved in bone osteoclastic resorption. MMP-9 Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived MMP-9 protein, expressed by HEK293 , with C-His labeled tag. The total length of MMP-9 Protein, Cynomolgus (HEK293, His) is 687 a.a., with molecular weight of 85-100 kDa.

HY-P70145A

	MMP-9 Protein, Human (HEK293, C-His) rHuMatrix metalloproteinase-9/MMP-9, His; Matrix metalloproteinase-9; 92 kDa gelatinase; 92 kDa type IV collagenase; Gelatinase B; MMP9	Human	HEK293
	MMP-9 Protein, a matrix metalloproteinase, plays a crucial role in localized extracellular matrix breakdown, facilitating leukocyte migration. Its potential involvement in bone osteoclastic resorption is suggested. MMP-9 cleaves KiSS1 and NINJ1, generating their secreted forms. It degrades type IV and type V collagen, producing distinct fragments, and fibronectin, while laminin and Pz-peptide remain unaffected. MMP-9 Protein, Human (HEK293, C-His) is the recombinant human-derived MMP-9 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of MMP-9 Protein, Human (HEK293, C-His) is 689 a.a., with molecular weight of ~82.5 kDa.

HY-P78492

	MMP-9 Protein, Human (HEK293, His-Avi) MMP-9; GELB; CLG4B; MANDP2; Gelatinase B	Human	HEK293
	MMP-9 Protein, a matrix metalloproteinase, plays a crucial role in localized extracellular matrix breakdown, facilitating leukocyte migration. Its potential involvement in bone osteoclastic resorption is suggested. MMP-9 cleaves KiSS1 and NINJ1, generating their secreted forms. It degrades type IV and type V collagen, producing distinct fragments, and fibronectin, while laminin and Pz-peptide remain unaffected. MMP-9 Protein, Human (HEK293, His-Avi) is the recombinant human-derived MMP-9 protein, expressed by HEK293 , with C-Avi, C-His labeled tag. The total length of MMP-9 Protein, Human (HEK293, His-Avi) is 688 a.a., with molecular weight of 85-100 kDa.

HY-P78175

	MMP-9 Protein, Human (Biotinylated, HEK293, His-Avi) MMP-9; GELB; CLG4B; MANDP2; Gelatinase B	Human	HEK293
	MMP-9 Protein, a matrix metalloproteinase, plays a crucial role in localized extracellular matrix breakdown, facilitating leukocyte migration. Its potential involvement in bone osteoclastic resorption is suggested. MMP-9 cleaves KiSS1 and NINJ1, generating their secreted forms. It degrades type IV and type V collagen, producing distinct fragments, and fibronectin, while laminin and Pz-peptide remain unaffected. MMP-9 Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived MMP-9 protein, expressed by HEK293 , with C-Avi, C-His labeled tag. The total length of MMP-9 Protein, Human (Biotinylated, HEK293, His-Avi) is 688 a.a., with molecular weight of 95-105 kDa.

HY-P700572

	MMP-9 Protein, Human (601a.a, P. pastoris, His) rHuMatrix metalloproteinase-9/MMP-9, His; Matrix metalloproteinase-9; 92 kDa gelatinase; 92 kDa type IV collagenase; Gelatinase B; MMP9	Human	P. pastoris
	MMP-9 Protein, a matrix metalloproteinase, plays a crucial role in localized extracellular matrix breakdown, facilitating leukocyte migration. Its potential involvement in bone osteoclastic resorption is suggested. MMP-9 cleaves KiSS1 and NINJ1, generating their secreted forms. It degrades type IV and type V collagen, producing distinct fragments, and fibronectin, while laminin and Pz-peptide remain unaffected. MMP-9 Protein, Human (601a.a, P. pastoris, His) is the recombinant human-derived MMP-9 protein, expressed by P. pastoris , with N-6*His labeled tag. The total length of MMP-9 Protein, Human (601a.a, P. pastoris, His) is 601 a.a., with molecular weight of 68.6 kDa.

HY-P70351A

	MMP-9 Protein, Mouse (HEK293, C-His) rMuMatrix metalloproteinase-9/MMP-9, His; Matrix metalloproteinase-9; MMP-9; 92 kDa gelatinase; 92 kDa type IV collagenase; Gelatinase B; GELB	Mouse	HEK293
	The MMP-9 protein is a matrix metalloproteinase that is critical for local extracellular matrix proteolysis and leukocyte migration. It is suggested that it may be involved in bone osteoclastic resorption. MMP-9 Protein, Mouse (HEK293, C-His) is the recombinant mouse-derived MMP-9 protein, expressed by HEK293 , with C-10*His labeled tag. The total length of MMP-9 Protein, Mouse (HEK293, C-His) is 711 a.a., with molecular weight of ~93.64 kDa.

HY-P71156

	Lipocalin-2/NGAL Protein, Human (HEK293, His) Neutrophil gelatinase-associated lipocalin; NGAL; 25 kDa alpha-2-microglobulin-related subunit of MMP-9; Lipocalin-2; Oncogene 24p3; Siderocalin LCN2; p25; HNL; NGAL	Human	HEK293
	Lipocalin-2/NGAL is an iron transporter that plays a crucial role in various cellular processes. It interacts with the siderophore 2,3-DHBA to transport iron into or out of cells depending on cellular needs. Lipocalin-2/NGAL Protein, Human (HEK293, His) is the recombinant human-derived Lipocalin-2/NGAL protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Lipocalin-2/NGAL Protein, Human (HEK293, His) is 178 a.a., with molecular weight of ~21-24 kDa.

Cat. No.	Product Name	Chemical Structure

HY-B0099S

Edaravone-d5
Edaravone-d₅ is a deuterium labeled Edaravone. Edaravone is a strong novel free radical scavenger, and inhibits MMP-9-related brain hemorrhage in rats treated with tissue plasminogen activator[1][2][3][4].

Cat. No.	Product Name	Application	Reactivity

HY-P80425

MMP9 Antibody (YA285)	WB, ICC/IF, IHC-P, FC	Human, Rat
MMP9 Antibody (YA285) is a non-conjugated and Rabbit origined monoclonal antibody about 78 kDa, targeting to MMP9. It can be used for WB,ICC/IF,IHC-P,FC assays with tag free, in the background of Human, Rat.

HY-P80756

MMP9 Antibody MMP9; CLG4B; Matrix metalloproteinase-9; MMP-9; 92 kDa gelatinase; 92 kDa type IV collagenase; Gelatinase B; GELB	WB, IHC-P, ICC/IF	Human, Mouse, Rat
MMP9 Antibody is a non-conjugated and Rabbit origined polyclonal antibody about 78 kDa, targeting to MMP9. It can be used for WB,IHC-P,ICC/IF assays with tag free, in the background of Human, Mouse, Rat.


Products	In-stock - + Add to Cart
Cat. No.
Species
Source
Tag
Accession
Gene ID
Molecular Weight
Purity
Endotoxin Level
Biological Activity
Appearance
Formulation
Storage & Stability
Shipping
Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

MMP9

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

NaturalProducts

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Natural
Products