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Results for "

MOLT-4

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ADC Cytotoxin (3) Antibiotic (3) Apoptosis (11) Autophagy (5) Bacterial (5) Bcl-2 Family (5) Biochemical Assay Reagents (1) Carbonic Anhydrase (1) Casein Kinase (3) Caspase (1) CCR (2) DNA/RNA Synthesis (5) E3 Ligase Ligand-Linker Conjugates (1) Endogenous Metabolite (1) Epigenetic Reader Domain (1) HDAC (2) HIV (2) Ligands for E3 Ligase (1) Molecular Glues (2) Necroptosis (1) Nucleoside Antimetabolite/Analog (2) Phosphodiesterase (PDE) (1) PI3K (2) PROTACs (4) SARS-CoV (1) Syk (1) Topoisomerase (3)
By Research Areas:	Cancer (32) Cardiovascular Disease (1) Endocrinology (2) Infection (8) Inflammation/Immunology (3) Neurological Disease (3)

By Targets:

ADC Cytotoxin (3)

Antibiotic (3)

Apoptosis (11)

Autophagy (5)

Bacterial (5)

Bcl-2 Family (5)

Biochemical Assay Reagents (1)

Carbonic Anhydrase (1)

Casein Kinase (3)

Caspase (1)

CCR (2)

DNA/RNA Synthesis (5)

E3 Ligase Ligand-Linker Conjugates (1)

Endogenous Metabolite (1)

Epigenetic Reader Domain (1)

HDAC (2)

HIV (2)

Ligands for E3 Ligase (1)

Molecular Glues (2)

Necroptosis (1)

Nucleoside Antimetabolite/Analog (2)

Phosphodiesterase (PDE) (1)

PI3K (2)

PROTACs (4)

SARS-CoV (1)

Syk (1)

Topoisomerase (3)

By Research Areas:

Cancer (32)

Cardiovascular Disease (1)

Endocrinology (2)

Infection (8)

Inflammation/Immunology (3)

Neurological Disease (3)

Inhibitors & Agonists

Peptides

Natural
Products

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-133557

XZ739	PROTACs Bcl-2 Family Apoptosis	Cancer
XZ739, a Cereblon-dependent PROTAC BCL-XL (Bcl-2 family member) degrader with a DC₅₀ value of 2.5 nM in MOLT-4 cells after 16 h treatment. XZ739 also induces cell death through caspase-mediated apoptosis .

HY-19725

A-1155463 10+ Cited Publications	Bcl-2 Family	Cancer
A-1155463 is a highly potent and selective BCL-XL inhibitor with an EC₅₀ of 70 nM in Molt-4 cell. A-1155463 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-N1555

Pseudotaraxasterol

Pseudotaraxasterol shows cytotoxic activity against MOLT-4 cells.

Pseudotaraxasterol
Pseudotaraxasterol shows cytotoxic activity against MOLT-4 cells.

HY-N10777

1-Ketoaethiopinone	Others	Cancer
1-Ketoaethiopinone is an abietane-diterpenoid. 1-Ketoaethiopinone has an α, β-unsaturated carbonyl function. 1-Ketoaethiopinone shows cytotoxic activity against human cancer cell lines MOLT-4 (human lymphoblastic leukemia) and MCF-7 (human breast adenocarcinoma) .

HY-155393

PROTAC BRD4 Degrader-22

PROTACs Epigenetic Reader Domain Cancer

PROTAC BRD4 Degrader-22 (Compd 44h) is a PROTAC-based BRD4 degrader, with a pDC₅₀ (MOLT4, 24 h) of 9.2 .
HY-156465

RIOK2-IN-2

Others Cancer

RIOK2-IN-2 (8) is a RIOK2 inhibitor, with IC₅₀ values of 3.02 μM and 5.34 μM in MKN-1 and MOLT4 cells, respectively .

PROTAC BRD4 Degrader-22	PROTACs Epigenetic Reader Domain	Cancer
PROTAC BRD4 Degrader-22 (Compd 44h) is a PROTAC-based *BRD4* degrader, with a pDC₅₀ (MOLT4, 24 h) of 9.2 .

RIOK2-IN-2	Others	Cancer
RIOK2-IN-2 (8) is a RIOK2 inhibitor, with IC₅₀ values of 3.02 μM and 5.34 μM in MKN-1 and MOLT4 cells, respectively .

HY-13518

Piceatannol 10+ Cited Publications Astringenin; trans-Piceatannol	Syk Autophagy Apoptosis Endogenous Metabolite	Cancer
Piceatannol is a well-known Syk inhibitor and reduces the expression of iNOS induced by TNF. Piceatannol is an effective agent for research of acute lung injury (ALI) . Piceatannol is a naturally occurring polyphenolic stilbene found in various fruits and vegetables and exhibits anticancer and anti-inflammatory properties . Piceatannol induces apoptosis in DLBCL cell lines . Piceatannol induces autophagy and apoptosis in MOLT-4 human leukemia cells ^[4].

HY-155522

WES-1	Carbonic Anhydrase	Cancer
WES-1 (Compound 8g) is an inhibitor of carbonic anhydrase IX (K_i: 55.9 μM). WES-1 has broad spectrum anti-proliferative activity against the cancer cells, such as leukemia (K-562 and MOLT-4), non-small cell lung cancer (NCI–H460), colon cancer (HCT 116 and HCT-15) and melanoma (LOX IMVI) cell lines .

HY-145322

TMX-4116	Casein Kinase Molecular Glues	Cancer
TMX-4116 is a casein kinase 1α (CK1α) degrader. TMX-4116 shows the degradation preference for CK1α with DC₅₀s less than 200 nM in MOLT4, Jurkat, and MM.1S cells. TMX-4116 can be used for the research of multiple myeloma .

HY-145321

TMX-4100	Phosphodiesterase (PDE) Molecular Glues	Cancer
TMX-4100 is a selective phosphodiesterase 6D (PDE6D) degrader. TMX-4100 shows a high degradation preference for PDE6D with the DC₅₀ values less than 200 nM in MOLT4, Jurkat, and MM.1S cells. TMX-4100 can be used for the research of multiple myeloma .

HY-W760183

EM12-SO2F	Others	Cancer
EM12-SO2F is a powerful covalent inhibitor of CRBN through binding at His353. EM12-SO2F is a useful chemical probe to investigate the CRBN. EM12-SO2F inhibits the degradation of IKZF1 by lenalidomide (HY-A0003) in MOLT4 cells

HY-15724

Vercirnon 1 Publications Verification GSK-1605786; CCX282-B; Traficet-EN	CCR	Inflammation/Immunology Endocrinology
Vercirnon (GSK1605786A) is an orally bioavailable, selective, and potent antagonist of CCR9. Vercirnon inhibits CCR9-mediated Ca ²⁺ mobilization and chemotaxis on Molt-4 cells with IC₅₀ values of 5.4 and 3.4 nM, respectively. Vercirnon is selective for CCR9 over CCR1-12 and CX3CR1-7 (IC₅₀s>10 µM for all). Vercirnon is an equipotent inhibitor of CCL25-directed chemotaxis of both splice forms of CCR9 (CCR9A and CCR9B) with IC₅₀ values of 2.8 and 2.6 nM, respectively .

HY-15724A

Vercirnon sodium 1 Publications Verification GSK-1605786 sodium; CCX282-B sodium; Traficet-EN sodium	CCR	Inflammation/Immunology Endocrinology
Vercirnon (GSK1605786A) sodium is an orally bioavailable, selective, and potent antagonist of CCR9. Vercirnon sodium inhibits CCR9-mediated Ca ²⁺ mobilization and chemotaxis on Molt-4 cells with IC₅₀ values of 5.4 and 3.4 nM, respectively. Vercirnon sodium is selective for CCR9 over CCR1-12 and CX3CR1-7 (IC₅₀s>10 µM for all). Vercirnon sodium is an equipotent inhibitor of CCL25-directed chemotaxis of both splice forms of CCR9 (CCR9A and CCR9B) with IC₅₀ values of 2.8 and 2.6 nM, respectively .

HY-N7944

Eucommiol	Others	Cancer
Eucommiol is a natural product that can be isolated from the roasted leaves of E. ulmoides. Eucommiol inhibits growth of Molt 4B cells. Eucommiol reduces spontaneous activity and increases the sleep ratio in mice .

HY-N10789

(2S)-4'-Hydroxy-7-methoxyflavan	Others	Cancer
(2S)-4'-Hydroxy-7-methoxyflavan is a Flavan. Flavan (4′-hydroxy-7-methoxyflavan) showed an important cytotoxic effect on human leukemic Molt 4 cells .

HY-152668

Urease-IN-4	Bacterial	Infection
Urease-IN-4 is an effective inhibitor of urease with an IC₅₀ value of 1.64 µM. Urease-IN-4 has low cytotoxicity and shows inhibitory activity on P. vulgaris with an IC₅₀ value of 15.27 µg/mL .

HY-152669

Urease-IN-5	Bacterial	Infection
Urease-IN-5 is an inhibitor of urease with an IC₅₀ value of 1.473 µM. Urease-IN-5 has low cytotoxicity and inhibitory activity on P. vulgaris with an IC₅₀ value of 17.78 µg/mL .

HY-149896

Antitumor agent-107	Biochemical Assay Reagents	Cancer
Antitumor agent-107 (compound 5h) is an anticancer agent that shows excellent inhibitory activity against leukemia cell lines (GI₅₀=0.32-1.34 μM). Antitumor agent-107 also shows antitumor activity against various other human cancer cell lines (GI₅₀ range 0.35-9.43 μM) .

HY-162377

HDAC-IN-70	HDAC Apoptosis Necroptosis	Cancer
HDAC-IN-70 (compound 4c) is HDAC6 inhibitor with the IC₅₀ values of 64.13 nM, 166 nM, 618 nM and 253 nM for HDAC6, HDAC1, HDAC2 and HDAC4, respectively. HDAC-IN-70 induces cell cycle arrest, apoptosis and necrotic. HDAC-IN-70 can be used for study of leukemia .

HY-131190

N-Boc-SBP-0636457-O-C3-COOH	E3 Ligase Ligand-Linker Conjugates	Cancer
N-Boc-SBP-0636457-OH is a synthesized E3 ligase ligand-linker conjugate that incorporates IAP ligand and a linker. N-Boc-SBP-0636457-OH can be used to design a PROTAC Bcl-xL degrader-1 (HY-131188) .

HY-131189

N-Boc-SBP-0636457-OH	Ligands for E3 Ligase	Cancer
N-Boc-SBP-0636457-OH, a ligand for E3 ubiquitin ligase, is used in the recruitment of IAP E3 ligases. N-Boc-SBP-0636457-OH can be connected to the ligand for Bcl-xL by a linker to form PROTAC Bcl-xL degrader-1 (HY-131188).

HY-14526

5-DACTHF 543U76; 5,11-Methenyltetrahydrohomofolate	Others	Cancer
5-DACTHF (543U76) is an inhibitor of purine de novo biosynthesis. 5-DACTHF is a GAR-TFase and AICAR-TFase inhibitor (IC₅₀: 3 and 94 μM). 5-DACTHF is a potent antitumor agent .

HY-115718

PZ703b 1 Publications Verification	PROTACs Bcl-2 Family	Cancer
PZ703b is a Bcl-xl PROTAC degrader that induces apoptosis and inhibits cancer cell proliferation. PZ703b can be used for the research of bladder cancer research .

HY-10224A

Panobinostat lactate LBH589 lactate; NVP-LBH589 lactate	HDAC HIV Autophagy Apoptosis	Infection Cancer
Panobinostat lactate is a potent and orally active non-selective HDAC inhibitor. Panobinostat lactate has antineoplastic activities. Panobinostat lactate effectively disrupts HIV latency. Panobinostat lactate induces cell apoptosis and autophagy. Panobinostat lactate can be used for the study of refractory or relapsed multiple myeloma ^[4] .

HY-115718B

PZ703b hydrochloride 1 Publications Verification	PROTACs Apoptosis Bcl-2 Family	Cancer
PZ703b hydrochloride is a Bcl-xl PROTAC degrader that induces apoptosis and inhibits cancer cell proliferation. PZ703b hydrochloride can be used for the research of bladder cancer research .

HY-137340

WH-10417-099

Others Cancer

WH-10417-099 is a degrader that could collectively induce degradation of the largest number of unique kinases (>125 unique kinases) .
HY-137341

SK-3-91

Others Cancer

SK-3-91 is a multi-kinase degrader. SK-3-91 could collectively induce degradation of the largest number of unique kinases (>125 unique kinases) .

WH-10417-099	Others	Cancer
WH-10417-099 is a degrader that could collectively induce degradation of the largest number of unique kinases (>125 unique kinases) .

SK-3-91	Others	Cancer
SK-3-91 is a multi-kinase degrader. SK-3-91 could collectively induce degradation of the largest number of unique kinases (>125 unique kinases) .

HY-N0097A

9-β-D-Arabinofuranosylguanine AraG	Others	Cancer
9-β-D-Arabinofuranosylguanine is a Guanosine (HY-N0097) analog and shows high affinity for deoxyguanosine kinase (dGK) with a K_m of 8.0 μM. 9-β-D-Arabinofuranosylguanine can be used for the research of T-cell lymphoblastic disease .

HY-13701

Nelarabine 1 Publications Verification 506U78; GW 506U78; Nelzarabine	Nucleoside Antimetabolite/Analog Apoptosis	Cancer
Nelarabine (506U78) is a nucleoside analogue and can be used for the research of T cell acute lymphoblastic leukemia (T-ALL) .

HY-B0464

Hydralazine hydrochloride 2 Publications Verification	Bcl-2 Family Caspase Apoptosis	Cardiovascular Disease Inflammation/Immunology Cancer
Hydralazine hydrochloride is an antihypertensive agent. Hydralazine hydrochloride can inhibit mitochondrial fission and human peritoneal mesothelial cell proliferation. Hydralazine hydrochloride has immunomodulation and anti-migratory effect. Hydralazine hydrochloride activates the intrinsic pathway of apoptosis and causes DNA damage ^[4] .

HY-14913

Apricitabine SPD754; AVX754	Nucleoside Antimetabolite/Analog HIV DNA/RNA Synthesis	Infection
Apricitabine (SPD754; AVX754), the (-) enantiomer of 2′-deoxy-3′-oxa-4′-thiocytidine (dOTC), is a highly selective and orally active HIV-1 reverse transcriptase (RT) inhibitor (K_i=0.08 μM), as well as inhibits DNA polymerases α, β, and γ with K_i value of 300 μM, 12 μM, and 112.25 μM, respectively . Apricitabine (SPD754; AVX754) shows promising antiretroviral efficacy, good tolerability and a low propensity for resistance selection in antiretroviral-naive HIV infection ^[2].

HY-120075

TJ191	Apoptosis	Cancer
TJ191 is a potent and specific anti-cancer agent that targets low TβRIII-expressing malignant T-cell leukemia/lymphoma cells. TJ191 has no affects on the proliferation of other cancer cells or normal fibroblasts or immune cells. TJ191 can be used for cancer research .

HY-16050

Plitidepsin 2 Publications Verification Aplidine; PM90001	DNA/RNA Synthesis SARS-CoV	Infection Cancer
Plitidepsin (Aplidine) is a potent anti-cancer agent by targeting eEF1A2 ( K_D=80 nM) . Plitidepsin possesses antiviral activity and is against SARS-CoV-2 with an IC₉₀ of 0.88 nM. Plitidepsin is usually used for multiple myeloma and advanced cancer research, and has the potential for COVID-19 research .

HY-13062

Daunorubicin hydrochloride 20+ Cited Publications Daunomycin hydrochloride; RP 13057 hydrochloride; Rubidomycin hydrochloride	Topoisomerase DNA/RNA Synthesis ADC Cytotoxin Bacterial Autophagy Apoptosis Antibiotic	Infection Neurological Disease Cancer
Daunorubicin (Daunomycin) hydrochloride is a topoisomerase II inhibitor with potent anti-tumor activity. Daunorubicin hydrochloride inhibits DNA and RNA synthesis. Daunorubicin hydrochloride is a cytotoxin that inhibits cancer cell viability and induces apoptosis and necrosis. Daunorubicin hydrochloride is also an anthracycline antibiotic. Daunorubicin hydrochloride can be used in the research of infection and variety of cancers, including leukemia, non-Hodgkin lymphomas, Ewing's sarcoma, Wilms' tumor ^[4] .

HY-13062A

Daunorubicin Daunomycin; RP 13057; Rubidomycin	Topoisomerase DNA/RNA Synthesis ADC Cytotoxin Autophagy Bacterial Antibiotic Apoptosis	Infection Neurological Disease Cancer
Daunorubicin (Daunomycin) is a topoisomerase II inhibitor with potent anti-tumor activity. Daunorubicin inhibits DNA and RNA synthesis. Daunorubicin is a cytotoxin that inhibits cancer cell viability and induces apoptosis and necrosis. Daunorubicin is also an anthracycline antibiotic. Daunorubicin can be used in the research of infection and variety of cancers, including leukemia, non-Hodgkin lymphomas, Ewing's sarcoma, Wilms' tumor ^[4] .

HY-12279C

Umbralisib hydrochloride 3 Publications Verification TGR-1202 hydrochloride; RP5264 hydrochloride	PI3K Casein Kinase	Cancer
Umbralisib (TGR-1202) hydrochloride is an orally active, potent and selective dual PI3Kδ and casein kinase-1-ε (CK1ε) inhibitor, with EC₅₀ of 22.2 nM and 6.0 μM, respectively. Umbralisib hydrochloride exhibits unique immunomodulatory effects on chronic lymphocytic leukemia (CLL) T cells. Umbralisib hydrochloride can be used for haematological malignancies reseach ^[4].

HY-12279A

Umbralisib tosylate TGR-1202 tosylate; RP5264 tosylate	PI3K Casein Kinase	Cancer
Umbralisib (TGR-1202) tosylate is an orally active, potent and selective dual PI3Kδ and casein kinase-1-ε (CK1ε) inhibitor, with EC₅₀ of 22.2 nM and 6.0 μM, respectively. Umbralisib tosylate exhibits unique immunomodulatory effects on chronic lymphocytic leukemia (CLL) T cells. Umbralisib tosylate can be used for haematological malignancies reseach ^[4].

HY-108876

Daunorubicin citrate Daunomycin(citrate); RP 13057(citrate); Rubidomycin(citrate)	Topoisomerase DNA/RNA Synthesis ADC Cytotoxin Autophagy Bacterial Antibiotic Apoptosis	Infection Neurological Disease Cancer
Daunorubicin (Daunomycin) citrate is a topoisomerase II inhibitor with potent anti-tumor activity. Daunorubicin citrate inhibits DNA and RNA synthesis. Daunorubicin citrate is a cytotoxin that inhibits cancer cell viability and induces apoptosis and necrosis. Daunorubicin citrate is also an anthracycline antibiotic. Daunorubicin citrate can be used in the research of infection and variety of cancers, including leukemia, non-Hodgkin lymphomas, Ewing's sarcoma, Wilms' tumor ^[4] .

Plitidepsin 2 Publications Verification Aplidine; PM90001	DNA/RNA Synthesis SARS-CoV	Infection Cancer
Plitidepsin (Aplidine) is a potent anti-cancer agent by targeting eEF1A2 ( K_D=80 nM) . Plitidepsin possesses antiviral activity and is against SARS-CoV-2 with an IC₉₀ of 0.88 nM. Plitidepsin is usually used for multiple myeloma and advanced cancer research, and has the potential for COVID-19 research .

Piceatannol 10+ Cited Publications Astringenin; trans-Piceatannol	Structural Classification Microorganisms Stilbenes Classification of Application Fields Rheum palmatum L. Polygonaceae Source classification Plants Disease Research Fields Cancer	Syk Autophagy Apoptosis Endogenous Metabolite
Piceatannol is a well-known Syk inhibitor and reduces the expression of iNOS induced by TNF. Piceatannol is an effective agent for research of acute lung injury (ALI) . Piceatannol is a naturally occurring polyphenolic stilbene found in various fruits and vegetables and exhibits anticancer and anti-inflammatory properties . Piceatannol induces apoptosis in DLBCL cell lines . Piceatannol induces autophagy and apoptosis in MOLT-4 human leukemia cells ^[4].

Plitidepsin 2 Publications Verification Aplidine; PM90001	Structural Classification Microorganisms Marine natural products Source classification Other marine organisms	DNA/RNA Synthesis SARS-CoV
Plitidepsin (Aplidine) is a potent anti-cancer agent by targeting eEF1A2 ( K_D=80 nM) . Plitidepsin possesses antiviral activity and is against SARS-CoV-2 with an IC₉₀ of 0.88 nM. Plitidepsin is usually used for multiple myeloma and advanced cancer research, and has the potential for COVID-19 research .

1-Ketoaethiopinone	Structural Classification Ardisia crenata Sims Terpenoids Source classification Diterpenoids Plants Myrsinaceae	Others
1-Ketoaethiopinone is an abietane-diterpenoid. 1-Ketoaethiopinone has an α, β-unsaturated carbonyl function. 1-Ketoaethiopinone shows cytotoxic activity against human cancer cell lines MOLT-4 (human lymphoblastic leukemia) and MCF-7 (human breast adenocarcinoma) .

Eucommiol	Garryaceae Aucuba japonica Thunb. Source classification Plants	Others
Eucommiol is a natural product that can be isolated from the roasted leaves of E. ulmoides. Eucommiol inhibits growth of Molt 4B cells. Eucommiol reduces spontaneous activity and increases the sleep ratio in mice .

(2S)-4'-Hydroxy-7-methoxyflavan	Other Terpenoids Phyllodium pulchellum (L.) Desv. Structural Classification Terpenoids Source classification Plants Compositae	Others
(2S)-4'-Hydroxy-7-methoxyflavan is a Flavan. Flavan (4′-hydroxy-7-methoxyflavan) showed an important cytotoxic effect on human leukemic Molt 4 cells .

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