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Results for "

MRG

" in MedChemExpress (MCE) Product Catalog:

11

Inhibitors & Agonists

2

Fluorescent Dye

2

Inhibitory Antibodies

2

Recombinant Proteins

13

Antibodies

7

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-164992
    Trastuzumab vedotin
    2 Publications Verification

    MRG002; Trastuzumab MMAE

    		 Antibody-Drug Conjugates (ADCs) EGFR Microtubule/Tubulin Cancer
    Trastuzumab vedotin (MRG002; Trastuzumab MMAE) is an antibody-drug conjugate and cytotoxin targeting HER2, with a Kd of 7.50E-11 M for human HER2. After binding to HER2, Trastuzumab vedotin undergoes internalization and lysosomal trafficking, delivering a cytotoxic payload to HER2-expressing cells and inducing tumor regression in in vivo xenograft models with HER2-expressing tumors. The anti-tumor activity of Trastuzumab vedotin is enhanced when used in combination with anti-PD-1 antibodies, and it exhibits preclinical anti-tumor activity in drug-resistant breast cancer, gastric cancer, and urothelial carcinoma PDX models. Trastuzumab vedotin has low antibody-dependent cellular cytotoxicity activity and can be used in studies related to HER2-positive breast cancer, HER2-positive gastric cancer, and unresectable locally advanced or metastatic HER2-positive urothelial carcinoma .
    Trastuzumab vedotin
  • HY-171265
    Becotatug vedotin

    MRG003

    		 Antibody-Drug Conjugates (ADCs) EGFR Cancer
    Becotatug vedotin (MRG003) is an Antibody-Drug Conjugate (ADC) that consists of an anti-EGFR humanized IgG1 monoclonal antibody Becotatug (HY-P990049) and MMAE (HY-15162). These two parts are connected through a valine-citrulline (valine-citrulline) linker, where the linker and MMAE constitute the ADC's Drug-Linker conjugate VcMMAE (HY-15575) .
    Becotatug vedotin
  • HY-P990049
    Becotatug

    JMT-101; MRG003 Antibody

    		 EGFR Cancer
    Becotatug (JMT-101) is a humanized IgG1 antibody targeting EGFR. Becotatug can also be conjugated to Afatinib (HY-10261) and Osimertinib (HY-15772) as a synthetic ADC. Becotatug can be used for the study of EGFR-mutated advanced non-small cell lung cancer (NSCLC) .
    Becotatug
  • HY-132601A
    Cobomarsen sodium

    MRG-106 sodium

    		 MicroRNA Cancer
    Cobomarsen sodium is an oligonucleotide inhibitor of miR-155. Cobomarsen sodium inhibits multiple gene pathways associated with cell survival (including JAK/STAT, MAPK/ERK and PI3K/AKT). Cobomarsen sodium can be used for the research of B-cell lymphoma .
    Cobomarsen sodium
  • HY-132602A
    Remlarsen sodium

    MRG-201 sodium

    		 MicroRNA Inflammation/Immunology
    Remlarsen (MRG-201), a miR-29b mimic, acts a miR-29b agonist. Remlarsen sodium has the potential for preventiong formation of a fibrotic scar or cutaneous fibrosis .
    Remlarsen sodium
  • HY-132602
    Remlarsen

    MRG-201

    		 MicroRNA Inflammation/Immunology
    Remlarsen (MRG-201), a miR-29b mimic, acts a miR-29b agonist. Remlarsen has the potential for preventiong formation of a fibrotic scar or cutaneous fibrosis .
    Remlarsen
  • HY-132601
    Cobomarsen

    MRG-106

    		 MicroRNA Cancer
    Cobomarsen (MRG-106) is an oligonucleotide inhibitor of miR-155. Cobomarsen inhibits multiple gene pathways associated with cell survival (including JAK/STAT, MAPK/ERK and PI3K/AKT). Cobomarsen can be used for the research of B-cell lymphoma .
    Cobomarsen
  • HY-RS08158
    MAS1L Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    MAS1L Human Pre-designed siRNA Set A contains three designed siRNAs for MAS1L gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    MAS1L Human Pre-designed siRNA Set A
    MAS1L Human Pre-designed siRNA Set A
  • HY-RS17908
    Fabp7 Mouse Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Fabp7 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Fabp7 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Fabp7 Mouse Pre-designed siRNA Set A
    Fabp7 Mouse Pre-designed siRNA Set A
  • HY-RS04663
    FABP7 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    FABP7 Human Pre-designed siRNA Set A contains three designed siRNAs for FABP7 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    FABP7 Human Pre-designed siRNA Set A
    FABP7 Human Pre-designed siRNA Set A
  • HY-P991989
    MRG004A Antibody

    		ADC Antibody Cancer
    MRG004A Antibody (HuSC1-39) is a monoclonal antibody inhibitor targeting tissue factor (TF). MRG004A Antibody can be used to synthesize the antibody-drug conjugate (ADC) MRG004A. MRG004A Antibody can be used to research related to cancer .
    MRG004A Antibody

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