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Results for "

MUC1-C

" in MedChemExpress (MCE) Product Catalog:

3

Inhibitors & Agonists

2

Peptides

Cat. No. Product Name Target Research Area
  • HY-P1925B
    L-GO-203 TFA

    		Peptides Cancer
    L-GO-203 TFA is a potent MUC1-C oncoprotein inhibitor. L-GO-203 TFA is an anti-cancer peptide for targeting intracellular proteins [1].
  • HY-P1925A
    GO-203 TFA
    2 Publications Verification

    		 PI3K Reactive Oxygen Species Apoptosis Cancer
    GO-203 TFA is a potent MUC1-C oncoprotein inhibitor. GO-203 TFA is an all D-amino acid peptide that consists of a poly-R transduction domain linked to a CQCRRKN motif that binds to the MUC1-C cytoplasmic tail and blocks MUC1-C homodimerization. GO-203 TFA downregulates TIGAR (TP53-induced glycolysis and apoptosis regulator) protein synthesis by inhibiting the PI3K-AKT-S6K1 pathway. GO-203 TFA induces the production of ROS and loss of mitochondrial transmembrane potential. GO-203 TFA inhibits the growth of colon cancer cells in vitro and as xenografts in nude mice [1] .

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