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Results for "

MetAP-2

" in MedChemExpress (MCE) Product Catalog:

13

Inhibitors & Agonists

1

Peptides

2

Recombinant Proteins

Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-128147
    MetAP2-IN-1

    		MetAP Cancer
    MetAP2-IN-1 is a MetAP2 inhibitor. MetAP2-IN-1 can be used for research in conditions mediated by angiogenesis .
    <em>MetAP2</em>-IN-1
  • HY-133016
    M8891

    		MetAP Cardiovascular Disease Cancer
    M8891 is an orally active, reversible and brain penetrant Methionine Aminopeptidase-2 (MetAP-2) inhibitor with an IC50 of 54 nM and a Ki of 4.33 nM. M8891 does not inhibit MetAP-1 (IC50>10 µM) . M8891 inhibits growth of primary endothelial cells as well as tumor cells and demonstrates antiangiogenic and antitumoral activity [2].
    M8891
  • HY-134183
    AUTAC1

    		AUTACs Autophagy Metabolic Disease Cancer
    AUTAC1 is a MetAP2-targeting autophagy-mediated degrader (AUTAC). AUTACs contain a degradation tag and a warhead to provide target specificity. AUTAC1 contains an FBnG (p-Fluorobenzyl Guanine) and a Fumagillol moiety. Fumagillol binds covalently to MetAP2 .
    AUTAC1
  • HY-P4344
    Met-Gly-Pro-AMC

    		MetAP Others
    Met-Gly-Pro-AMC is a fluorescent peptide substrate of MetAP2 .
    Met-Gly-Pro-AMC
  • HY-RS08350
    METAP2 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    METAP2 Human Pre-designed siRNA Set A contains three designed siRNAs for METAP2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    METAP2 Human Pre-designed siRNA Set A
    METAP2 Human Pre-designed siRNA Set A
  • HY-13731
    PPI-2458

    		MetAP Inflammation/Immunology Cancer
    PPI-2458 is a potent, orally active, selective and irreversible inhibitor of methionine aminopeptidase-2 (MetAP-2). PPI-2458 can be used for arthritis and lymphoma research [2].
    PPI-2458
  • HY-120868
    TP-004

    		MetAP Metabolic Disease
    TP-004 is a potent and reversible inhibitor of methionine aminopeptidase 2 (MetAP2), with an IC50 of 6 nM .
    TP-004
  • HY-133016A
    (R)-M8891

    		MetAP Others
    (R)-M8891 (compound R-9) is a less active isomer of M8891. M8891 is an orally active, reversible and brain penetrant Methionine Aminopeptidase-2 (MetAP-2) inhibitor .
    (R)-M8891
  • HY-109188
    Relzomostat

    		MetAP Metabolic Disease
    Relzomostat is a methionine aminopeptidase 2 (MetAP2) inhibitor.Relzomostat may be useful for the research of obesity, type 2 diabetes, and other obesity-associated conditions .
    Relzomostat
  • HY-14811
    Beloranib

    ZGN-440; CKD-732 free base

    		 MetAP Metabolic Disease
    Beloranib is a fumagillin-class methionine aminopetidase-2 (MetAP2) inhibitor. Beloranib decreases food intake, body weight, fat mass, and the size of adipocytes.
    Beloranib
  • HY-150409
    TSPO ligand-2

    		AUTACs Cancer
    TSPO ligand-2 is a ligand of AUTAC1. AUTAC1 contains an p-fluorobenzylguanine (FBnG) and a Fumagillol moiety, which can silence endogenous MetAP2 in HeLa cells .
    TSPO ligand-<em>2</em>
  • HY-158006
    SDX-7539

    		MetAP Cancer
    SDX-7539 is a selective inhibitor for Methionine aminopeptidase type 2 (MetAP2). SDX-7539 inhibits proliferarion of HUVECs with an IC50 of 120 μM. SDX-7539 exhibits antitumor activity in NSCLC xenograft athymic nude mice .
    SDX-7539
  • HY-114196
    Aclimostat

    ZGN-1061

    		 MetAP Metabolic Disease
    Aclimostat (ZGN-1061) is a potent inhibitor of the MetAP2 enzyme and displays favorable efficacy and safety in preclinical studies. ZGN-1061 produced similar efficacy as beloranib for weight loss, improvements in metabolic parameters in a mouse model of obesity and insulin resistance, and concordant changes in gene transcription in HepG2 cells .
    Aclimostat

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