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75

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Click Chemistry

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-17040
    Darunavir
    5+ Cited Publications

    TMC114; UIC-94017

    		 HIV HIV Protease Infection Inflammation/Immunology
    Darunavir (TMC114), an orally active next generation HIV protease inhibitor, has a similar antiviral activity against the mutant and the wild-type viruses. Darunavir (TMC114) is potent against laboratory HIV-1 strains and primary clinical isolates (IC50 = 0.003 μM; IC90 = 0.009 μM) with minimal cytotoxicity .
    Darunavir
  • HY-W013172
    Norgestimate

    		Progesterone Receptor Endocrinology
    Norgestimate, a synthetic progesterone analog, is an orally active progestin with highly selective progestational activity and minimal androgenicity. Norgestimate is used for an oral contraceptive . Norgestimate is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Norgestimate
  • HY-B0389A
    D-Glucose-13C6
    3 Publications Verification

    Glucose-13C6; D-(+)-Glucose-13C6; Dextrose-13C6

    		 Endogenous Metabolite Others Metabolic Disease
    D-Glucose- 13C6 is a stable isotope-labeled counterpart of D-glucose (HY-B0389). D-Glucose- 13C6 can be used as a metabolic tracer to trace glucose-related synthetic catabolism or as synthesis ingredient, minimal media reagent, and internal standard .
    D-Glucose-13C6
  • HY-132929
    TCMDC-125431

    		Parasite Infection
    TCMDC-125431 is a novel disruptor of the malaria parasite calcium dynamics but minimally inhibits heme crystallization.
    TCMDC-125431
  • HY-132930
    TCMDC-136230

    		Parasite Infection
    TCMDC-136230 is a novel disruptor of the malaria parasite calcium dynamics but minimally inhibits heme crystallization.
    TCMDC-136230
  • HY-136607
    DiAzK

    		Others Others
    DiAzK is a bifunctional amino acid. DiAzK can be inserted into almost any protein interface with minimal structural perturbation using genetic code expansion .
    DiAzK
  • HY-N0610
    trans-Cinnamic acid

    trans-3-Phenylacrylic acid

    		 Bacterial Endogenous Metabolite Infection Cancer
    trans-Cinnamic acid is a natural antimicrobial, with minimal inhibitory concentration (MIC) of 250 μg/mL against fish pathogen A. sobria, SY-AS1 .
    trans-Cinnamic acid
  • HY-108293
    Promestriene

    		Estrogen Receptor/ERR Endocrinology Cancer
    Promestriene is a synthetic diethyl-ether of estradiol and a locally effective estrogen. Promestriene has an efficient action on vaginal atrophy while it is minimally absorbed .
    Promestriene
  • HY-N3065
    Pierreione B

    		Others Cancer
    Pierreione B is a pyranoisoflavone, that can be isolated from the leaves and twigs of Antheroporum pierrei. Pierreione B demonstrates solid tumor selectivity with minimal cytotoxicity .
    Pierreione B
  • HY-116169
    KUC-7322

    		Adrenergic Receptor Metabolic Disease Endocrinology
    KUC-7322, a selective β3 -adrenoceptor agonist, is the active form of ritobegron. Ritobegron decreases intravesical pressure with minimal effects on the cardiovascular system.
    KUC-7322
  • HY-111594
    Homo-PROTAC cereblon degrader 1

    		PROTACs Cancer
    Homo-PROTAC cereblon degrader 1 (compound 15a) is a highly potent and efficient Cereblon (CRBN) degrader with only minimal effects on IKZF1 and IKZF3 .
    Homo-PROTAC cereblon degrader 1
  • HY-139716
    IMD-catechol

    		NF-κB Inflammation/Immunology
    IMD-catechol is a novel imidazoquinolinone-NF-κB immunomodulator dimer that improves efficacy in a CT26 mouse colon carcinoma tumor model while eliciting minimal adjuvant toxicity.
    IMD-catechol
  • HY-124489
    2-Hydroxyestradiol

    		Endogenous Metabolite Metabolic Disease
    2-Hydroxyestradiol, a metabolite of 17β-estradiol with minimal estrogenic activity, possesses antioxidant effects and reacts with DNA to form stable adducts and exerts genotoxicity .
    2-Hydroxyestradiol
  • HY-101190
    Volixibat

    SHP626; LUM002

    		 Apical Sodium-Dependent Bile Acid Transporter Metabolic Disease
    Volixibat (SHP626) is a highly selective, minimally absorbed, and competitive apical sodium-dependent bile acid transporter (ASBT) inhibitor. Volixibat has potential for treatment for non-alcoholic steatohepatitis (NASH) .
    Volixibat
  • HY-128770
    LY3154207
    1 Publications Verification

    		 Dopamine Receptor Neurological Disease
    LY3154207 is a potent, subtype selective, and orally available human dopamine D1 receptor positive allosteric modulator (PAM) with minimal allosteric agonist activity (EC50=3 nM) .
    LY3154207
  • HY-D1117
    NADA-green

    NADA hydrochloride

    		 Fluorescent Dye Infection
    NADA-green is a fluorescent D-amino acid probe. NADA-green is efficiently incorporated into the peptidoglycan of diverse bacterial species peptidoglycan biosynthesis. NADA-green allows probing of bacterial growth with minimal perturbation .
    NADA-green
  • HY-115930
    Bim-IN-1

    		Bcl-2 Family Cardiovascular Disease
    Bim-IN-1 is a potent Bim expression inhibitor. Bim-IN-1 reduces Bim expression levels and has little inhibitory effect upon protein kinase A activity and minimal toxicity .
    Bim-IN-1
  • HY-134669
    CypK

    N-Cyclopropene-L-Lysine

    		 Others Cancer
    CypK (N-Cyclopropene-L-Lysine), a cyclopropene derivative of lysine, is efficiently incorporated into antibodies through genetic-code expansion. CypK is a minimal bioorthogonal handle for the creation of stable therapeutic protein conjugates .
    CypK
  • HY-102023
    GNF351
    3 Publications Verification

    		 Aryl Hydrocarbon Receptor Others
    GNF351 is a full aryl hydrocarbon receptor (AHR) antagonist. GNF351 competes with a photoaffinity AHR ligand for binding to the AHR with an IC50 of 62 nM. GNF351 is minimal toxicity in mouse or human keratinocytes .
    GNF351
  • HY-157028
    Antiparasitic agent-19

    		Others Infection
    Antiparasitic agent-19 (compound 40) is a compound with broad-spectrum antiparasitic activity. Antiparasitic agent-19 has minimal toxicity against Trypanosoma brucei, Leishmania Infantum, and Trypanosoma cruzi .
    Antiparasitic agent-19
  • HY-10025
    (S)-SW IV-52 hydrochloride

    		Apoptosis Cancer
    (S)-SW IV-52 hydrochloride is a small molecule that can induce apoptosis in ovarian cancer. (S)-SW IV-52 hydrochloride has minimal single-agent activity at concentrations up to 200 μM .
    (S)-SW IV-52 hydrochloride
  • HY-120675
    SSTC3
    1 Publications Verification

    		 Casein Kinase Wnt Cancer
    SSTC3 is a casein kinase 1α (CK1α) activator (Kd = 32 nM) that inhibits WNT signaling (EC50 = 30 nM). SSTC3 exhibits minimal gastrointestinal toxicity compared to other classes of WNT inhibitors .
    SSTC3
  • HY-W013172R
    Norgestimate (Standard)

    		Progesterone Receptor Endocrinology
    Norgestimate (Standard) is the analytical standard of Norgestimate. This product is intended for research and analytical applications. Norgestimate, a synthetic progesterone analog, is an orally active progestin with highly selective progestational activity and minimal androgenicity. Norgestimate is used for an oral contraceptive .
    Norgestimate (Standard)
  • HY-120004
    PF-06827443

    		mAChR Infection
    PF-06827443 is a potent, low-clearance, orally bioavailable, and CNS-penetrant M1-selective positive allosteric modulator (PAM) with minimal agonist activity. PF-06827443 induce cholinergic AEs and convulsion .
    PF-06827443
  • HY-A0273
    Propyphenazone

    4-Isopropylantipyrine; Isopropylphenazone

    		 COX Inflammation/Immunology
    Propyphenazone (4-Isopropylantipyrine) is an orally active nonacidic pyrazole nonsteroidal anti-inflammatory drug (NSAID). Propyphenazone is a weak nonselective COX inhibitor. Propyphenazone has the effect of reducing pain and antipyretic activity with minimal anti-inflammatory activity .
    Propyphenazone
  • HY-132931
    TCMDC-125457

    		Parasite Infection
    TCMDC-125457 is potent in inducing calcium redistribution but minimally inhibits heme crystallization. TCMDC-125457 demonstrated high efficacy when pulsed in a single-dose combination with artesunate against tightly synchronized artemisinin-resistant ring-stage parasites.
    TCMDC-125457
  • HY-155376
    mTOR inhibitor-14

    		mTOR Cancer
    mTOR inhibitor-14 (compound 14c) is a potent mTOR inhibitor. mTOR inhibitor-14 also shows minimal CYP2C8 inhibition. mTOR inhibitor-14 can inhibit tumor growth .
    mTOR inhibitor-14
  • HY-160060
    MA3 aptamer sodium

    		Mucin Cancer
    MA3 aptamer sodium is an 86-base long DNA aptamer targeting the mucin MUC1. MA3 aptamer sodium binds to the peptide epitope of mucin 1 (MUC1) with a Kd of 38.3 nM and has minimal cross-reactivity with albumin .
    MA3 aptamer sodium
  • HY-D1426
    Di-12-ANEPPQ

    		Fluorescent Dye Neurological Disease
    Di-12-ANEPPQ is a fast-responding membrane potential dye. Di-12-ANEPPQ, the lipophilic dye, shows cell-specific loading and Golgi-like staining patterns with minimal background fluorescence in the slices of neocortex and hippocampus .
    Di-12-ANEPPQ
  • HY-N0610S
    trans-Cinnamic acid-d5

    trans-3-Phenylacrylic acid-d5

    		 Bacterial Endogenous Metabolite
    trans-Cinnamic acid-d5 is the deuterium labeled trans-Cinnamic acid[1]. trans-Cinnamic acid is a natural antimicrobial, with minimal inhibitory concentration (MIC) of 250 μg/mL against fish pathogen A. sobria, SY-AS1[2].
    trans-Cinnamic acid-d5
  • HY-N0610S1
    trans-Cinnamic acid-d7

    trans-3-Phenylacrylic acid-d7

    		 Bacterial Endogenous Metabolite
    trans-Cinnamic acid-d7 is the deuterium labeled trans-Cinnamic acid[1]. trans-Cinnamic acid is a natural antimicrobial, with minimal inhibitory concentration (MIC) of 250 μg/mL against fish pathogen A. sobria, SY-AS1[2].
    trans-Cinnamic acid-d7
  • HY-131045
    HADA hydrochloride
    1 Publications Verification

    HCC-Amino-D-alanine hydrochloride

    		 Bacterial Infection
    HADA hydrochloride (HCC-Amino-D-alanine hydrochloride) is a blue (λem~450 nm) fluorescent D-amino acid (FDAA). FDAAs are efficiently incorporated into the peptidoglycans (PGs) of diverse bacterial species at the sites of PG biosynthesis, allowing specific and covalent probing of bacterial growth with minimal perturbation .
    HADA hydrochloride
  • HY-156283
    Antibacterial agent 159

    		Antibiotic Infection
    Antibacterial agent 159 (Compound 6d) is an antibiotic. Antibacterial agent 159 can effective against impetigo and C. difficile infection (CDI). Antibacterial agent 159 has no observed recurrence for C. difficile and exertes a minimal impact on the beneficial gut microbiome .
    Antibacterial agent 159
  • HY-135146
    GSK-3484862
    5+ Cited Publications

    		 DNA Methyltransferase Cancer
    GSK-3484862 is a non-covalent inhibitor for DNA methyltransferase (Dnmt1). GSK-3484862 induces DNA hypomethylation to against cancer. GSK-3484862 mediates dramatic demethylation in murine embryonic stem cells with minimal non-specific toxicity .
    GSK-3484862
  • HY-13556
    Arzoxifene

    LY353381; SERM III

    		 Estrogen Receptor/ERR Metabolic Disease
    Arzoxifene (LY353381) is an orally active selective estrogen receptor modulator with a fixed ring structure similar to raloxifene. Arzoxifene has minimal side effects with powerful antiestrogenic effects on breast cancer and endometrium, with equally strong favorable estrogenic effects on bone and lipid profile .
    Arzoxifene
  • HY-112658
    p-Iodoclonidine hydrochloride

    		Adrenergic Receptor Adenosine Receptor Endocrinology
    p-Iodoclonidine hydrochloride is a partial agonist of α2-adrenergic receptor. p-Iodoclonidine hydrochloride also has minimal agonist activity in inhibiting adenylate cyclase in platelet membranes, and potentiates ADP induced platelet aggregation with an EC50 of 1.5 μM .
    p-Iodoclonidine hydrochloride
  • HY-13649
    Indibulin

    ZIO 301; D 24851

    		 Microtubule/Tubulin Apoptosis Neurological Disease Cancer
    Indibulin (ZIO 301), an orally applicable inhibitor of tubulin assembly, shows potent anticancer activity with a minimal neurotoxicity. Indibulin reduces inter-kinetochoric tension, produces aberrant spindles, activates mitotic checkpoint proteins Mad2 and BubR1, and induces mitotic arrest and apoptosis .
    Indibulin
  • HY-141716
    SW2_110A

    		Histone Methyltransferase Cancer
    SW2_110A is a selective chromobox 8 chromodomain (CBX8 ChD) inhibitor with a Kd of 800 nM. SW2_110A shows minimal 5-fold selectivity for CBX8 ChD over all other CBX paralogs in vitro .
    SW2_110A
  • HY-124489S1
    2-Hydroxyestradiol-d5

    		Endogenous Metabolite Infection
    2-Hydroxyestradiol-d5 is the deuterium labeled 2-Hydroxyestradiol. 2-Hydroxyestradiol, a metabolite of 17β-estradiol with minimal estrogenic activity, possesses antioxidant effects and reacts with DNA to form stable adducts and exerts genotoxicity[[1][3][4].
    2-Hydroxyestradiol-d5
  • HY-124489S
    2-Hydroxyestradiol-13C6

    		Isotope-Labeled Compounds Endogenous Metabolite Metabolic Disease
    2-Hydroxyestradiol- 13C6 is the 13C-labeled 2-Hydroxyestradiol. 2-Hydroxyestradiol, a metabolite of 17β-estradiol with minimal estrogenic activity, possesses antioxidant effects and reacts with DNA to form stable adducts and exerts genotoxicity[1][3].
    2-Hydroxyestradiol-13C6
  • HY-108592
    UCL 2077

    		Potassium Channel Neurological Disease
    UCL 2077 is a selective slow-afterhyperpolarization (sAHP) channel blocker (IC50 = 500 nM in hippocampal neurons in culture), having minimal effects on Ca2+ channels, action potentials, input resistance and the medium after hyperpolarization . UCL 2077 is also a subtype-selective blocker of the epilepsy associated KCNQ channels .
    UCL 2077
  • HY-18977
    KML29
    2 Publications Verification

    		 MAGL Metabolic Disease Inflammation/Immunology
    KML29 is an extremely selective, orally active and irreversible MAGL inhibitor, with IC50 values of 15 nM, 43 nM and 5.9 nM for mouse, rat and human MAGL, respectively. KML29 exhibits minimal cross-reactivity toward other central and peripheral serine hydrolases, including no detectable activity against FAAH .
    KML29
  • HY-149610
    Antibacterial agent 156

    		Bacterial Infection
    Antibacterial agent 156 (Compound 57) is a selective and potent bactericidal against C. difficile and targets cell-wall synthesis. Antibacterial agent 156 exhibits bactericidal activity with the minimal inhibitory concentration of 0.5 μg/mL and 1 μg/mL against MIMIC50 (101 strains) and MIC90 (101 strains) .
    Antibacterial agent 156
  • HY-125300
    Oligomycin E

    		Fungal Antibiotic Cancer
    Oligomycin E is a antitumor antibiotic that can be isolated from Streptomyces. Oligomycin E has significant antifungal activity, showing minimal inhibitory concentrations (MICs) values between 2 and 75μg/mL. Oligomycin E has strong antitumor activity against HeLa cells, with an IC50 of 0.014 μg/mL .
    Oligomycin E
  • HY-D1815
    Allophycocyanin
    1 Publications Verification

    APC Dye

    		 Fluorescent Dye Others
    Allophycocyanin (APC Dye) is a light-harvesting protein, containing strongly coupled dimers of chromophores. Allophycocyanin serve as a minimal system to examine photosynthetic energy transfer. Allophycocyanin strongly absorbs far-red light (FRL), and expresses during acclimation to low light, likely associates with chlorophyll a-containing photosystem I .
    Allophycocyanin
  • HY-D2220
    SiR-Hoechst

    		DNA Stain Others
    SiR-Hoechst is a far-red fluorescent DNA probe being used widely for time-lapse imaging of living cells. SiR-Hoechst is minimally toxic at concentrations as high as 10-25 µM. SiR-Hoechst induces DNA damage responses and G2 arrest at concentrations well below 1 µM .
    SiR-Hoechst
  • HY-128153
    Thienopyridone

    		Phosphatase Apoptosis Cancer
    Thienopyridone is a potent and selective phosphatase of regenerating liver (PRL) phosphatase inhibitor with IC50s of 173 nM, 277 nM and 128 nM for PRL-1, PRL-2, and PRL-3, respectively. Thienopyridone shows minimal effects on other phosphatases. Thienopyridone induces p130Cas cleavage and apoptosis and has anticancer effects .
    Thienopyridone
  • HY-13995B
    Sevelamer carbonate
    1 Publications Verification

    		 Others Metabolic Disease
    Sevelamer carbonate is an orally active and non-calcium-based phosphate binding agent and used for the hyperphosphatemia of chronic kidney disease (CKD)research. Sevelamer carbonate effectively lowers serum phosphorus levels hile having minimal effect on serum calcium or serum chloride levels in vivo. Sevelamer carbonate is considered as an improved, buffered form of sevelamer (HY-13995) .
    Sevelamer carbonate
  • HY-108492
    TC-SP 14

    		LPL Receptor Inflammation/Immunology
    TC-SP 14 (compound 14) is an orally active and potent S1P1 agonist (EC50 = 0.042 μM) with minimal activity at S1P3 (EC50 = 3.47 μM). TC-SP 14 significantly reduces blood lymphocyte counts and attenuates a delayed type hypersensitivity (DTH) response to antigen challenge .
    TC-SP 14
  • HY-150505
    DC-U4106

    		Deubiquitinase Apoptosis Cancer
    DC-U4106 is a USP8 targeting inhibitor with the Kdvalue of 4.7 μM and the IC50 value of 1.2 μM. DC-U4106 can target the ubiquitin pathway and facilitate the degradation of Erα. DC-U4106 inhibits tumor growth with minimal toxicity and has the potential for the research of breast cancer .
    DC-U4106

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