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Mitosis Inhibitors

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Mitosis (64) NEKs (2) Akt (1) Antibiotic (1) APC (1) Apoptosis (24) Aurora Kinase (8) Autophagy (6) Bcr-Abl (2) c-Fms (1) c-Kit (1) Deubiquitinase (1) DNA/RNA Synthesis (2) Drug Derivative (1) EGFR (3) ERK (2) FGFR (1) Fungal (2) G-quadruplex (1) Haspin Kinase (1) Herbicide (7) Isotope-Labeled Compounds (3) JAK (2) Kinesin (4) MAP3K (1) MASTL (1) MELK (1) Microtubule/Tubulin (27) Monoamine Oxidase (3) Mps1 (2) mTOR (1) Paraptosis (1) PDGFR (2) Polo-like Kinase (PLK) (3) Reactive Oxygen Species (ROS) (1) Reference Standards (5) Separase (1) Ser/Thr Protease (2) STAT (3) Topoisomerase (1) VEGFR (2) α-synuclein (3)
By Research Areas:	Cancer (55) Infection (2) Inflammation/Immunology (5) Neurological Disease (3)
Click Chemistry:	Alkynes (2)

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Natural
Products

Isotope-Labeled Compounds

Click Chemistry

Targets Recommended: Mitosis Serpin NEKs

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-100368

MELK-8a 3 Publications Verification NVS-MELK8a	PDGFR Haspin Kinase MELK Mitosis	Cancer
MELK-8a (NVS-MELK8a) is a highly potent and selective maternal embryonic leucine zipper kinase (MELK) inhibitor with IC₅₀ of 2 nM. MELK-8a also inhibits Flt3 (ITD), Haspin, PDGFRα with IC₅₀s of 0.18, 0.19, and 0.42 μM, respectively. MELK plays an essential role in regulating cell mitosis in a subset of cancer cells .

HY-156437

NBI-961	Apoptosis Ser/Thr Protease NEKs Mitosis	Cancer
NBI-961 is a potent NEK2 inhibitor that inhibits proteasomal degradation. NBI-961 induces G2/mitosis arrest and apoptosis in diffuse large B cell lymphoma (DLBCL) cells .

HY-136369

Ethofumesate	Herbicide Mitosis	Others
Ethofumesate, a chiral herbicide, acts by inhibiting mitosis and reducing photosynthesis and plant respiration .

HY-14846

Litronesib 1 Publications Verification LY2523355	Kinesin Mitosis	Cancer
Litronesib (LY2523355) is a selective mitosis-specific kinesin Eg5 inhibitor, with antitumor activity .

HY-W014240

Chlorpropham	Herbicide Mitosis	Others
Chlorpropham is a carbamate herbicide and plant growth regulator. Chlorpropham inhibits mitosis and cell division by interfering with the organisation of the spindle microtubules .

HY-B2050

Trifluralin	Herbicide Microtubule/Tubulin	Others
Trifluralin is a selective, preemergence, soil-applied herbicide providing control of many important annual grass and broadleaf weed species. Trifluralin prevents weed growth by inhibiting root development through the interruption of mitosis. Trifluralin binds to tubulin and results in the failure of spindle apparatus and cell plate formation. Trifluralin inhibits radicle development on roots. Trifluralin inhibits cell mitosis. Trifluralin is considered to be neurotoxic and haematotoxic .

HY-16036A

ALB-109564 hydrochloride 12'-Methylthiovinblastine hydrochloride	Microtubule/Tubulin Mitosis	Cancer
ALB-109564 (12'-Methylthiovinblastine) hydrochloride, a tubulin inhibitor, is a cytotoxic agent designed to kill cancer cells by disrupting mitosis .

HY-164454

AJI-100	Aurora Kinase STAT JAK Mitosis	Inflammation/Immunology
AJI-100 is a dual-target inhibitor of Aurora kinase A and JAK2 with IC₅₀ values of 12.7 nM and 18.5 nM, respectively. AJI-100 directly blocks Aurora kinase A to inhibit T cell mitosis and cell polarity, and inhibits JAK2 activation to inhibit STAT3 phosphorylation, thereby reducing the differentiation of TH1 and TH17 cells. AJI-100 can be used in studies on regulating immune responses and preventing graft-versus-host disease (GVHD) .

HY-124790

KSP-IA	Kinesin Mitosis	Cancer
KSP-IA (compound 17) is a potent kinesin spindle protein (KSP) inhibitor with an IC₅₀ value of 3.6 nM. KSP-IA inhibits cell mitosis .

HY-164501

Mps-BAY1	Apoptosis Mps1 Mitosis	Cancer
Mps-BAY1 is an MPS1 inhibitor with anticancer activity. Mps-BAY1 inhibits cell proliferation and induces apoptosis by activating mitotic catastrophe in cancer cells, generating global aneuploidy and polyploidy. Mps-BAY1 can be used in the study of colorectal cancer and cervical cancer .

HY-150046

Nek2-IN-6	NEKs	Cancer
Nek2-IN-6 (Compound 28e) is a potent never in mitosis (NIMA) related kinase 2 (Nek2) inhibitor .

HY-B2050S

Trifluralin-d14	Isotope-Labeled Compounds Microtubule/Tubulin	Others
Trifluralin-d₁₄ is the deuterium labeled Trifluralin. Trifluralin is a selective, preemergence, soil-applied herbicide providing control of many important annual grass and broadleaf weed species. Trifluralin prevents weed growth by inhibiting root development through the interruption of mitosis. Trifluralin binds to tubulin and results in the failure of spindle apparatus and cell plate formation. Trifluralin inhibits radicle development on roots. Trifluralin inhibits cell mitosis. Trifluralin is considered to be neurotoxic and haematotoxic .

HY-13647

HMN-176	Polo-like Kinase (PLK) Mitosis	Cancer
HMN-176 is a stilbene derivative which inhibits mitosis, interfering with polo-like kinase-1 (plk1), without significant effect on tubulin polymerization.

HY-156958

S-72	Apoptosis STAT Microtubule/Tubulin Mitosis	Inflammation/Immunology
S-72 inhibits tubulin polymerization and further triggers mitosis-phase cell cycle arrest and cell apoptosis, in addition to suppressing STAT3 signaling .

HY-136369R

Ethofumesate (Standard)	Herbicide Mitosis Reference Standards	Others
Ethofumesate (Standard) is the analytical standard of Ethofumesate. This product is intended for research and analytical applications. Ethofumesate, a chiral herbicide, acts by inhibiting mitosis and reducing photosynthesis and plant respiration .

HY-136369S

Ethofumesate-d5	Isotope-Labeled Compounds Herbicide	Others
Ethofumesate-d₅ is the deuterium labeled Ethofumesate (HY-136369). Ethofumesate, a chiral herbicide, acts by inhibiting mitosis and reducing photosynthesis and plant respiration .

HY-B2050R

Trifluralin (Standard)	Reference Standards Microtubule/Tubulin Herbicide	Others
Trifluralin (Standard) is the analytical standard of Trifluralin. This product is intended for research and analytical applications. Trifluralin is a selective, preemergence, soil-applied herbicide providing control of many important annual grass and broadleaf weed species. Trifluralin prevents weed growth by inhibiting root development through the interruption of mitosis. Trifluralin binds to tubulin and results in the failure of spindle apparatus and cell plate formation. Trifluralin inhibits radicle development on roots. Trifluralin inhibits cell mitosis. Trifluralin is considered to be neurotoxic and haematotoxic .

HY-33046

N-Boc-dolaproine (2R,3R)-BOC-dolaproine	Microtubule/Tubulin Mitosis	Cancer
N-Boc-dolaproine (Dap) is the amino acid residue of the pentapeptide Dolastatin 10 (HY-15580). Dolastatin 10 inhibits tubulin polymerization and mitosis and has anticancer activity .

HY-43304

N-Boc-dolaproine-methyl	Microtubule/Tubulin Mitosis	Cancer
N-Boc-dolaproine-methyl is the amino acid residue of the pentapeptide Dolastatin 10 (HY-15580). Dolastatin 10 inhibits tubulin polymerization and mitosis and has anticancer activity .

HY-42912A

N-Boc-dolaproine-OH dicyclohexylamine	Microtubule/Tubulin Mitosis	Cancer
N-Boc-dolaproine-OH dicyclohexylamine is the amino acid residue of the pentapeptide Dolastatin 10 (HY-15580). Dolastatin 10 inhibits tubulin polymerization and mitosis and has anticancer activity .

HY-129715

MPI-0441138	Apoptosis Mitosis	Cancer
MPI-0441138 is an inducer of apoptosis and an inhibitor of mitosis. MPI-0441138 can induce DNA breaks and induce cytochrome c translocation, leading to tumor cell death .

HY-42912

N-Boc-dolaproine-OH ((+)-phenylethylamine)	Microtubule/Tubulin Mitosis	Cancer
N-Boc-dolaproine-OH ((+)-phenylethylamine) is the amino acid residue of the pentapeptide Dolastatin 10 (HY-15580). Dolastatin 10 inhibits tubulin polymerization and mitosis and has anticancer activity .

HY-13520

Nocodazole Maximum Cited Publications 81 Publications Verification Oncodazole; R17934	Bcr-Abl Autophagy Microtubule/Tubulin Apoptosis Mitosis	Cancer
Nocodazole (Oncodazole) is a rapidly-reversible inhibitor of microtubule. Nocodazole binds to β-tubulin and disrupts microtubule assembly/disassembly dynamics, which prevents mitosis and induces apoptosis in tumor cells. Nocodazole inhibits Bcr-Abl.

HY-108330

AG126 2 Publications Verification Tyrphostin AG126	ERK Mitosis	Inflammation/Immunology
AG126 is a tyrosine kinase inhibitor, can inhibit the phosphorylation of ERK1 and ERK2 at 25-50 μM. AG126 can be used in meiosis, mitosis, and postmitotic research .

HY-33046A

N-Boc-dolaproine dicyclohexylamine (2R,3R)-BOC-dolaproine dicyclohexylamine	Microtubule/Tubulin Mitosis	Cancer
N-Boc-dolaproine dicyclohexylamine is an amino acid residue of the pentapeptide Dolastatin 10 (HY-15580). Dolastatin 10 inhibits tubulin polymerization and mitosis and has anticancer activity. And contains dicyclohexylamine .

HY-49053

N-Boc-dolaproine-amide-Me-Phe	Microtubule/Tubulin Mitosis	Cancer
N-Boc-dolaproine-amide-Me-Phe is the amino acid residue of the pentapeptide Dolastatin 10 (HY-15580). Dolastatin 10 inhibits tubulin polymerization and mitosis and has anticancer activity .

HY-129288

GW837016X NEU-391	EGFR Paraptosis Mitosis	Infection
GW837016X (NEU-391) is an orally active ErbB-2 kinase covalent inhibitor. GW837016X also is a potent antitrypanosome agent. GW837016X inhibits mitosis and cytokinesis .

HY-N0488A

Vincristine Leurocristine; NSC-67574; 22-Oxovincaleukoblastine	Microtubule/Tubulin Antibiotic Mitosis	Cancer
Vincristine (Leurocristine) is a microtubule-destabilizing agent (MDA). Vincristine binds to tubulin and inhibits the formation of microtubules, thereby inhibiting mitosis of the cancer cell. Vincristine is used to research hematologic cancers, such as leukemia and lymphoma, and childhood sarcomas .

HY-W014240S1

Chlorpropham-d7	Isotope-Labeled Compounds Mitosis	Others
Chlorpropham-d₇ is the deuterium labeled Chlorpropham . Chlorpropham is a carbamate herbicide and plant growth regulator. Chlorpropham inhibits mitosis and cell division by interfering with the organisation of the spindle microtubules .

HY-121801

Zarilamid	Fungal Microtubule/Tubulin Mitosis	Infection
Zarilamid is a fungicide which is active against a broad spectrum of Oomycete fungi. Zarilamid inhibits nuclear division in germinating zoospore cysts of Phytophthora capsici. Zarilamide inhibits growth of tobacco roots and causes swelling of the root tips, destructs microtubule cytoskeleton and inhibits mitosis .

HY-101071

(S)-Monastrol (+)-Monastrol	Kinesin Mitosis	Cancer
(S)-Monastrol ((+)-Monastrol) is an allosteric inhibitor of the mitotic kinesin Eg5 that exhibits an antiproliferative effect against several cancer cell lines. (S)-Monastrol arrests mammalian cells in mitosis with monopolar spindles .

HY-78932C

(2S,3R)-Dap-NE hydrochloride	Microtubule/Tubulin Mitosis	Cancer
(2S,3R)-Dap-NE hydrochloride is the amino acid residue of the pentapeptide Dolastatin 10 (HY-15580). Dolastatin 10 inhibits tubulin polymerization and mitosis and has anticancer activity .

HY-78932D

(2R,3R)-Dap-NE hydrochloride	Drug Derivative Mitosis	Cancer
(2R,3R)-Dap-NE hydrochloride is the amino acid residue of the pentapeptide Dolastatin 10 (HY-15580). Dolastatin 10 inhibits tubulin polymerization and mitosis and has anticancer activity .

HY-W014240R

Chlorpropham (Standard)	Herbicide Mitosis Reference Standards	Others
Chlorpropham (Standard) is the analytical standard of Chlorpropham. This product is intended for research and analytical applications. Chlorpropham is a carbamate herbicide and plant growth regulator. Chlorpropham inhibits mitosis and cell division by interfering with the organisation of the spindle microtubules .

HY-112136

TAO Kinase inhibitor 1 3 Publications Verification CP 43	MAP3K Mitosis	Cancer
TAO Kinase inhibitor 1 (compound 43) is a selective, ATP-competitive thousand-and-one amino acid kinases (TAOK) inhibitor with IC₅₀s of 11 to 15 nM for TAOK1 and 2, respectively. TAO Kinase inhibitor 1 delays mitosis and induces mitotic cell death .

HY-122236

UMK57	Others Mitosis	Others
UMK57 is a small molecule compound that specifically promotes k-MT attachment error correction to inhibit chromosome missegregation, which can improve chromosome segregation fidelity by destabilizing kinetochore microtubule (k-MT) attachment during mitosis .

HY-145967

FT709 1 Publications Verification	Deubiquitinase Mitosis	Cancer
FT709 is a potent and selective USP9X inhibitor, an IC₅₀ of 82 nM. USP9X has been linked with centrosome function, chromosome alignment during mitosis, EGF receptor degradation, chemo-sensitization, and circadian rhythms .

HY-111425

SSE15206	Apoptosis Microtubule/Tubulin Mitosis	Cancer
SSE15206 is a microtubule polymerization inhibitor (GI₅₀ = 197 nM in HCT116 cells) that overcomes multidrug resistance. Causes aberrant mitosis resulting in G2/M arrest due to incomplete spindle formation in cancer cells .

HY-13520R

Nocodazole (Standard)	Bcr-Abl Autophagy Microtubule/Tubulin Apoptosis Mitosis	Cancer
Nocodazole (Standard) is the analytical standard of Nocodazole. This product is intended for research and analytical applications. Nocodazole (Oncodazole) is a rapidly-reversible inhibitor of microtubule. Nocodazole binds to β-tubulin and disrupts microtubule assembly/disassembly dynamics, which prevents mitosis and induces apoptosis in tumor cells. Nocodazole inhibits Bcr-Abl.

HY-10919

C-1311	Topoisomerase Mitosis	Cancer
C-1311 shows to inhibit the catalytic activity of DNA topoisomerase II in vitro and in tumour cells. C-1311 prolongs G2 arrest followed by G2 to M transit and cell death during mitosis in the process of mitotic catastrophe .

HY-13589

Cemadotin LU103793 free base	Microtubule/Tubulin Mitosis	Cancer
Cemadotin (LU103793) is a water-soluble synthetic analogue of Dolastatin 15 (HY-P1126) that inhibits cell proliferation in vitro and the growth of tumor xenografts in mice. Cemadotin blocks cells at mitosis, and exhibits K_i value of 1 μM for inhibiting tubulin. Cemadotin can be used to research anticancer .

HY-13589A

Cemadotin hydrochloride LU103793 hydrochloride	Microtubule/Tubulin Mitosis	Cancer
Cemadotin (LU103793) hydrochloride is a water-soluble synthetic analogue of Dolastatin 15 (HY-P1126) that inhibits cell proliferation in vitro and the growth of tumor xenografts in mice. Cemadotin hydrochloride blocks cells at mitosis, and exhibits K_i value of 1 μM for inhibiting tubulin. Cemadotin hydrochloride can be used to research anticancer .

HY-108330R

AG126 (Standard)	ERK Mitosis	Inflammation/Immunology
AG126 (Standard) is the analytical standard of AG126. This product is intended for research and analytical applications. AG126 is a tyrosine kinase inhibitor, can inhibit the phosphorylation of ERK1 and ERK2 at 25-50 μM. AG126 can be used in meiosis, mitosis, and postmitotic research .

HY-12797

GF 15	Microtubule/Tubulin Mitosis	Cancer
GF 15 is an inhibitor of centrosomal clustering during cell mitosis, with an EC₅₀ value of 900 nM for inducing multipolar spindles. GF 15 is a derivative of griseofulvin that inhibits tubulin polymerization at concentrations above 25 μM. GF 15 inhibits tumor growth and significantly prolongs survival in mouse xenograft models of human colon cancer and multiple myeloma .

HY-153384

EAPB 02303	Apoptosis Microtubule/Tubulin Mitosis	Cancer
EAPB 02303 is a microtubule-disrupting agent and inhibitor. EAPB 02303 induces mitosis arrest and impairment of spindle assembly. Thus, EAPB 02303 induces apoptosis and exhibits antitumor activity. EAPB 02303 also exhibits a potent synergy with Paclitaxel (HY-B0015) at lower concentrations .

HY-138084

SIC5-6	Separase Mitosis	Cancer
SIC5-6 is a potent Separase inhibitor. Separase, a large cysteine protease, involves in chromosome segregation during mitosis and meiosis, DNA damage repair, centrosome disengagement and duplication, spindle stabilization and elongation. Separase is highly overexpressed in many solid cancers, serves as an attractive chemotherapeutic target .

HY-13737

R1530 1 Publications Verification	Apoptosis VEGFR FGFR Mitosis	Cancer
R1530 is a highly potent, orally active, dual-acting *mitosis/angiogenesis* inhibitor, with anti-tumor and anti-angiogenic activities. R1530 is a multikinase inhibitor which binds to 31 kinases with K_d values of <500 nM. R1530 inhibits VGFR2 and FGFR1 with IC₅₀ of 10 nM and 28 nM, respectively. R1530 triggers apoptosis (mitotic catastrophe) or senescence .

HY-164455

AJI-214	STAT JAK Aurora Kinase Mitosis	Inflammation/Immunology
AJI-214 is a dual-target inhibitor of Aurora kinase A and JAK2. AJI-214 directly blocks Aurora kinase A to inhibit T cell mitotic progression and cell polarity, and inhibits JAK2 activation to inhibit STAT3 phosphorylation, thereby reducing the differentiation of TH1 and TH17 cells. AJI-214 can be used in studies on regulating immune responses and preventing graft-versus-host disease (GVHD) .

HY-W543137

PT-ttpy	G-quadruplex DNA/RNA Synthesis Mitosis	Cancer
Pt-ttpy, a metallo-organic complex and potent G-quadruplex ligand, effectively triggers substantial telomere-related DNA damage in cancer cells by inhibiting telomerase and/or telomere functions, while also causing various chromatin abnormalities during mitosis, such as chromatin bridges, ultrafine bridges (UFBs), and double-stranded breaks (DSBs).

HY-13691

MKC-1 Ro-31-7453	Apoptosis Akt mTOR Microtubule/Tubulin Mitosis	Cancer
MKC-1 (Ro-31-7453) is an orally active and potent cell cycle inhibitor with broad antitumor activity. MKC-1 inhibits the Akt/mTOR pathway. MKC-1 arrests cellular mitosis and induces cell apoptosis by binding to a number of different cellular proteins including tubulin and members of the importin β family .

Cat. No.	Product Name	Type

HY-W543137

PT-ttpy	Biochemical Assay Reagents
Pt-ttpy, a metallo-organic complex and potent G-quadruplex ligand, effectively triggers substantial telomere-related DNA damage in cancer cells by inhibiting telomerase and/or telomere functions, while also causing various chromatin abnormalities during mitosis, such as chromatin bridges, ultrafine bridges (UFBs), and double-stranded breaks (DSBs).

Cat. No.	Product Name	Target	Research Area

HY-13589

Cemadotin LU103793 free base	Microtubule/Tubulin Mitosis	Cancer
Cemadotin (LU103793) is a water-soluble synthetic analogue of Dolastatin 15 (HY-P1126) that inhibits cell proliferation in vitro and the growth of tumor xenografts in mice. Cemadotin blocks cells at mitosis, and exhibits K_i value of 1 μM for inhibiting tubulin. Cemadotin can be used to research anticancer .

HY-13589A

Cemadotin hydrochloride LU103793 hydrochloride	Microtubule/Tubulin Mitosis	Cancer
Cemadotin (LU103793) hydrochloride is a water-soluble synthetic analogue of Dolastatin 15 (HY-P1126) that inhibits cell proliferation in vitro and the growth of tumor xenografts in mice. Cemadotin hydrochloride blocks cells at mitosis, and exhibits K_i value of 1 μM for inhibiting tubulin. Cemadotin hydrochloride can be used to research anticancer .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-107811

Harmol 1 Publications Verification	Neurological Disease Classification of Application Fields Peganum harmala Linn. Source classification Pyridine Alkaloids Plants Endogenous metabolite Indole Alkaloids Alkaloids Monophenols Zygophyllaceae Phenols Disease Research Fields	Autophagy α-synuclein Apoptosis Monoamine Oxidase Mitosis
Harmol is an orally active β-carboline alkaloid. Harmol is a TFEB activator and monoamine oxidase inhibitor. Harmol can induce cell mitosis, Autophagy and Apoptosis. Harmol promotes the degradation of α-synuclein by regulating the autophagy-lysosomal pathway. Harmol has anti-tumor, anti-depressant and anti-aging activities. Harmol improves motor impairment in a mouse Parkinson's disease model .

HY-N0488A

Vincristine Leurocristine; NSC-67574; 22-Oxovincaleukoblastine	Apocynaceae Alkaloids Structural Classification Classification of Application Fields Source classification Plants Disease Research Fields Alkaloid Dimers Catharanthus roseus (L.) G. Don Cancer	Microtubule/Tubulin Antibiotic Mitosis
Vincristine (Leurocristine) is a microtubule-destabilizing agent (MDA). Vincristine binds to tubulin and inhibits the formation of microtubules, thereby inhibiting mitosis of the cancer cell. Vincristine is used to research hematologic cancers, such as leukemia and lymphoma, and childhood sarcomas .

HY-N14734

Disorazol A	Structural Classification Natural Products Microorganisms Source classification	Apoptosis Fungal Microtubule/Tubulin Mitosis
Disorazol A1 is an tubulin inhibitor with antifungal activity. Disorazol A1 functions by inhibiting tubulin polymerization, interfering with microtubule formation, blocking mitosis, thus arresting the cell cycle at the G₂/M phase and inducing apoptosis. Disorazol A1 also exhibits an inhibitory effect against L929 mouse fibroblasts with an IC₅₀ value of 3 pM. Disorazol A1 causes the accumulation of p53 protein in the cell nucleus. Disorazol A1 is promising for research of cancers .

HY-107811R

Harmol (Standard)	Alkaloids Monophenols Zygophyllaceae Peganum harmala Linn. Source classification Phenols Pyridine Alkaloids Plants Endogenous metabolite Indole Alkaloids	Apoptosis Monoamine Oxidase Autophagy α-synuclein Mitosis Reference Standards
Harmol (Standard) is the analytical standard of Harmol (HY-107811). This product is intended for research and analytical applications. Harmol hydrochloride is an orally active β-carboline alkaloid. Harmol hydrochloride is a TFEB activator and monoamine oxidase inhibitor. Harmol can induce cell mitosis, Autophagy and Apoptosis. Harmol promotes the degradation of α-synuclein by regulating the autophagy-lysosomal pathway. Harmol has anti-tumor, anti-depressant and anti-aging activities. Harmol improves motor impairment in a mouse Parkinson's disease model .

Cat. No.	Product Name	Chemical Structure

HY-B2050S

Trifluralin-d14

Trifluralin-d₁₄ is the deuterium labeled Trifluralin. Trifluralin is a selective, preemergence, soil-applied herbicide providing control of many important annual grass and broadleaf weed species. Trifluralin prevents weed growth by inhibiting root development through the interruption of mitosis. Trifluralin binds to tubulin and results in the failure of spindle apparatus and cell plate formation. Trifluralin inhibits radicle development on roots. Trifluralin inhibits cell mitosis. Trifluralin is considered to be neurotoxic and haematotoxic .

HY-136369S

Ethofumesate-d5
Ethofumesate-d₅ is the deuterium labeled Ethofumesate (HY-136369). Ethofumesate, a chiral herbicide, acts by inhibiting mitosis and reducing photosynthesis and plant respiration .

HY-W014240S1

Chlorpropham-d7
Chlorpropham-d₇ is the deuterium labeled Chlorpropham . Chlorpropham is a carbamate herbicide and plant growth regulator. Chlorpropham inhibits mitosis and cell division by interfering with the organisation of the spindle microtubules .

Cat. No.	Product Name		Classification

HY-134061

Arecaidine propargyl ester hydrobromide		Alkynes
Arecaidine propargyl ester hydrobromide is an agonist of M2 muscarinic acetylcholine receptors and has the activity of inhibiting tumor cell proliferation. The application of arecaidine propargyl ester hydrobromide has shown that it can reduce the number of ovarian cancer cells in vitro and induce apoptosis and the production of reactive oxygen species (ROS) at specific concentrations. Arecaidine propargyl ester hydrobromide can also arrest cells at the G2/M phase of the cell cycle and increase the percentage of abnormal mitosis. Arecaidine propargyl ester hydrobromide is more sensitizing to ovarian surface epithelial cells with higher M2 receptor levels than to cancer cells. Arecaidine propargyl ester hydrobromide exhibits the effect of lowering arterial blood pressure when interacting with the cardiovascular system in a natural physiological state, indicating its potential pharmacological application .

HY-129510

4-Methyl erlotinib		Alkynes
4-Methyl erlotinib, is a potent and selective epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor. 4-Methyl erlotinib potently inhibits EGF-mediated tumor cell mitosis by reducing EGFr-specific tyrosine phosphorylation. Using a mouse model of human tumor transplantation, 4-Methyl erlotinib demonstrated significant and sustained suppression of EGFr phosphotyrosine levels, resulting in significant growth inhibition of EGFr-dependent human cancers .

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