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Mmp9 Inhibitors

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Akt (5) Aminopeptidase (1) Angiotensin-converting Enzyme (ACE) (2) Antibiotic (1) Apoptosis (15) Autophagy (2) Bacterial (1) Chloride Channel (1) COX (2) FAK (2) Microtubule/Tubulin (1) MMP (65) mTOR (1) NF-κB (4) P-glycoprotein (1) p38 MAPK (1) PI3K (1) Proteasome (1) Reactive Oxygen Species (2) Src (1)
By Research Areas:	Cancer (48) Cardiovascular Disease (8) Infection (2) Inflammation/Immunology (19) Metabolic Disease (4) Neurological Disease (3)

Inhibitors & Agonists

Peptides

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-135232

MMP-9-IN-1 5 Publications Verification	MMP	Cancer
MMP-9-IN-1 is a specific matrix metalloproteinase-9 (MMP-9) inhibitor, which selectively target the hemopexin (PEX) domain of MMP-9, but not other MMPs .

HY-P1789A

CTTHWGFTLC, CYCLIC TFA	MMP	Inflammation/Immunology Cancer
CTTHWGFTLC, CYCLIC TFA is a cyclic peptide inhibitor for matrix metalloproteinases MMP-2 and *MMP-9. The IC₅₀* value for MMP-9 is ~8 μM .

HY-P1789

CTTHWGFTLC, CYCLIC	MMP	Inflammation/Immunology Cancer
CTTHWGFTLC, CYCLIC is a cyclic peptide inhibitor for matrix metalloproteinases MMP-2 and *MMP-9. The IC₅₀* value for MMP-9 is ~8 μM .

HY-116302

MMP-9-IN-9	MMP	Neurological Disease Inflammation/Immunology
MMP-9-IN-9 (compound 4f) is a slective *MMP-9* inhibitor with an IC₅₀ of 5 nM. MMP-9-IN-9 shows selective for MMP-9 over MMP-1 and MMP-13. MMP-9-IN-9 shows strong anti-inflammatory and neuroprotective effects .

HY-146218

MMP-9-IN-5	MMP Akt Apoptosis	Cancer
MMP-9-IN-5 is a *MMP-9* inhibitor (IC₅₀: 4.49 nM) that forms hydrogen bond with MMP-9. MMP-9-IN-5 also inhibits _AKT activity (IC₅₀: 1.34 nM). MMP-9-IN-5 shows cell cytotoxicity and induces cell apoptosis. MMP-9-IN-5 can be used in the research of cancers .

HY-146216

MMP-9-IN-3	MMP Akt Apoptosis	Cancer
MMP-9-IN-3 is a *MMP-9* inhibitor (IC₅₀: 5.56 nM) that forms hydrogen bond with MMP-9. MMP-9-IN-3 also inhibits AKT activity (IC₅₀: 2.11 nM). MMP-9-IN-3 shows cell cytotoxicity and induces cell apoptosis. MMP-9-IN-3 can be used in the research of cancers .

HY-146217

MMP-9-IN-4	MMP Akt Apoptosis	Cancer
MMP-9-IN-4 is a *MMP-9* inhibitor (IC₅₀: 7.46 nM) that has H-π interactions with MMP-9. MMP-9-IN-4 also inhibits _AKT activity (IC₅₀: 8.82 nM). MMP-9-IN-4 shows cell cytotoxicity and induces cell apoptosis. MMP-9-IN-4 can be used in the research of cancers .

HY-103482

JNJ0966

5+ Cited Publications

MMP Cancer

JNJ0966 is a highly selective MMP-9 zymogen inhibitor with an IC₅₀ of 440 nM.

JNJ0966 5+ Cited Publications	MMP	Cancer
JNJ0966 is a highly selective MMP-9 zymogen inhibitor with an IC₅₀ of 440 nM.

HY-153913

MMP-9-IN-7	MMP	Inflammation/Immunology
MMP-9-IN-7 is a potent *MMP9* inhibitor with an IC₅₀ of 0.52 μM in proMMP9/MMP3 P126 activation assay. MMP-9-IN-7 is extracted from patent WO2012162468 (example 59), and can be used for MMP9/MMP13 mediated syndrome research .

HY-161285

MMP-9/10-IN-2	MMP	Cancer
MMP-9/10-IN-2 (compound 6e) is a potent inhibitor of MMP10 and *MMP9, with IC₅₀* of 0.076 μM for MMP10, and 93.18% inhibition at 0.5 μM for *MMP9. MMP-9*/10-IN-2 plays an important role in anti-tumor .

HY-149848

MMP-9-IN-6

MMP Inflammation/Immunology

MMP-9-IN-6 (Compound 3g) is a MMP-9 inhibitor with IC₅₀ value of 50 μM, which has good anti-ulcer effect .

MMP-9-IN-6	MMP	Inflammation/Immunology
MMP-9-IN-6 (Compound 3g) is a *MMP-9* inhibitor with IC₅₀ value of 50 μM, which has good anti-ulcer effect .

HY-155960

SH491	Others	Inflammation/Immunology
SH491 (Compound 33) is an antiosteoporosis agent. SH491 inhibits RANKL-induced osteoclast differentiation on bone-marrow-derived monocytes (BMMs) (IC₅₀: 11.8 nM). SH491 inhibits the expression of osteoclastogenesis-related marker genes (TRAP, CTSK, MMP-9, and ATPase v0d2) and proteins (TRAP, CTSK, MMP-9) .

HY-116399

MMP-2/MMP-9-IN-1	MMP	Cancer
MMP-2/MMP-9-IN-1 is a highly selective, orally active and potent type IV collagenase (MMP-9 and MMP-2) inhibitor with IC₅₀s of 0.24 and 0.31 μM for MMP-9 and MMP-2, respectively. MMP-2/MMP-9-IN-1 is orally active in animal models of tumor growth and metastasis. MMP-2/MMP-9-IN-1 can be used for the research of cancer .

HY-N6862

Lucideric acid A	MMP	Cancer
Lucideric acid A is a natural compound isolated from Ganoderma lucidum, inhibits PMA-induced *MMP-9* activity, with anti-invasive effect on hepatoma cells .

HY-N10176

D-Isofloridoside	Reactive Oxygen Species MMP	Cardiovascular Disease
D-Isofloridoside, one of the polysaccharide precursors, has the activity of scavenging free radicals, inhibiting ROS expression, and inhibiting MMP-2 and MMP-9 .

HY-N6860

Lucidenic acid C	MMP	Cancer
Lucidenic acid C is a natural compound isolated from Ganoderma lucidum, inhibits PMA-induced *MMP-9* activity, with anti-invasive effect on hepatoma cells .

HY-12170

Prinomastat 2 Publications Verification AG3340; KB-R9896	MMP Apoptosis	Cancer
Prinomastat (AG3340) is a broad spectrum, potent, orally active metalloproteinase (MMP) inhibitor with IC₅₀s of 79, 6.3 and 5.0 nM for MMP-1, MMP-3 and *MMP-9, respectively. Prinomastat inhibits* MMP-2, MMP-3 and *MMP-9* with K_is of 0.05 nM, 0.3 nM and 0.26 nM, respectively. Prinomastat crosses blood-brain barrier. Antitumor avtivity .

HY-P0273

Histatin 5

MMP Inflammation/Immunology

Histatin 5 inhibits the activity of the host matrix metalloproteinases MMP-2 and MMP-9 with IC₅₀s of 0.57 and 0.25 μM, respectively.
HY-P0273A

Histatin 5 TFA

MMP Inflammation/Immunology

Histatin 5 TFA inhibits the activity of the host matrix metalloproteinases MMP-2 and MMP-9 with IC₅₀s of 0.57 and 0.25 μM, respectively.

Histatin 5	MMP	Inflammation/Immunology
Histatin 5 inhibits the activity of the host matrix metalloproteinases MMP-2 and *MMP-9* with IC₅₀s of 0.57 and 0.25 μM, respectively.

Histatin 5 TFA	MMP	Inflammation/Immunology
Histatin 5 TFA inhibits the activity of the host matrix metalloproteinases MMP-2 and *MMP-9* with IC₅₀s of 0.57 and 0.25 μM, respectively.

HY-12170A

Prinomastat hydrochloride 2 Publications Verification AG3340 hydrochloride; KB-R9896 hydrochloride	MMP Apoptosis	Cancer
Prinomastat hydrochloride (AG3340 hydrochloride) is a broad spectrum, potent, orally active metalloproteinase (MMP) inhibitor with IC₅₀s of 79, 6.3 and 5.0 nM for MMP-1, MMP-3 and *MMP-9, respectively. Prinomastat hydrochloride inhibits* MMP-2, MMP-3 and *MMP-9* with K_is of 0.05 nM, 0.3 nM and 0.26 nM, respectively. Prinomastat hydrochloride can cross blood-brain barrier. Antitumor avtivity .

HY-128026

MMP-9/MMP-13 Inhibitor I	MMP	Inflammation/Immunology
MMP-9/MMP-13 Inhibitor I is a potent *MMP-9* and MMP-13 inhibitor with IC₅₀s of both 0.9 nM. MMP-9/MMP-13 Inhibitor I shows >20-folds selectivity for MMP-9/MMP-13 over other MMPs .

HY-N2117

Isoginkgetin 10+ Cited Publications	MMP Akt NF-κB Proteasome Apoptosis Autophagy	Inflammation/Immunology Cancer
Isoginkgetin is a pre-mRNA splicing inhibitor inhibitor. Isoginkgetin also inhibits activities of both Akt, NF-κB and *MMP-9. Isoginkgetin inhibits* the activity of the 20S proteasome, induces apoptosis and activates autophagy .

HY-19956

GI254023X

5+ Cited Publications

GI4023; SRI028594
MMP Cancer

GI254023X is a potent MMP9 and ADAM10 inhibitor with IC₅₀s of 2.5 and 5.3 nM, respectively.

GI254023X 5+ Cited Publications GI4023; SRI028594	MMP	Cancer
GI254023X is a potent *MMP9* and ADAM10 inhibitor with IC₅₀s of 2.5 and 5.3 nM, respectively.

HY-157138

MMP-9-IN-8	Others	Cancer
MMP-9-IN-8 (Compound 3) is an MMP-9 inhibitor with inhibitory activities of 42.16% and 58.28% at 10 μM and 50 μM concentrations, respectively. MMP-9-IN-8 has anti-cancer activity and can induce apoptosis in MCF-7 cells with an IC₅₀ value of 23.42 μM .

HY-162038

RXP03

MMP Others

RXP03 is a MMPs inhibitor with the K_i of 20 nM, 2.5 nM, 10 nM, 5nM and 105 nM for MMP-2, MMP-8, MMP-9, MMP-11, MMP-14, respectively .

RXP03	MMP	Others
RXP03 is a MMPs inhibitor with the K_i of 20 nM, 2.5 nM, 10 nM, 5nM and 105 nM for MMP-2, MMP-8, MMP-9, MMP-11, MMP-14, respectively .

HY-13564

Batimastat 5+ Cited Publications BB94	MMP	Cancer
Batimastat is a potent broad spectrum MMP inhibitor with IC₅₀ of 3, 4, 4, 6, and 20 nM for MMP-1, MMP-2, *MMP-9, MMP-7* and MMP-3, respectively.

HY-13564A

Batimastat sodium salt BB-94 sodium salt	MMP	Cancer
Batimastat sodium salt is a potent broad spectrum MMP inhibitor with IC₅₀ of 3, 4, 4, 6, and 20 nM for MMP-1, MMP-2, *MMP-9, MMP-7* and MMP-3, respectively.

HY-110046

CL-82198 hydrochloride	MMP	Others
CL-82198 hydrochloride is a selective inhibitor of MMP-13. CL-82198 hydrochloride binds to the entire S1’ pocket of MMP-13, which is the basis of its selectivity against MMP-1, MMP-9, and TACE .

HY-119423

MMP Inhibitor II	MMP	Cancer
MMP Inhibitor II (compound 4e) is a potent, reversible pan-MMP inhibitor with IC₅₀ values of 24 nM, 18.4 nM, 30 nM, and 2.7 nM for MMP-1,MMP-3, MMP-7, and MMP-9, respectively .

HY-106992

S 3304	MMP	Cancer
S 3304 is a novel matrix metalloproteinases (MMP) inhibitor specific for MMP-2 and *MMP-9*. S 3304 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-114396

BR351

MMP Cancer

BR351 is a brain penetrant MMP inhibitor with IC₅₀s of 4, 2, 11, 50 nM for MMP2, MMP8, MMP9 and MMP13, respectively .

BR351	MMP	Cancer
BR351 is a brain penetrant MMP inhibitor with IC₅₀s of 4, 2, 11, 50 nM for MMP2, MMP8, MMP9 and MMP13, respectively .

HY-W011085

CP-471474	MMP	Inflammation/Immunology
CP-471474 is an orally active and pan MMP inhibitor, with IC₅₀ values of 1170 nM (MMP-1), 0.7 nM (MMP-2), 16 nM (MMP-3), 13 nM (MMP-9) and 0.9 nM (MMP-13), respectively .

HY-N1454

Apigenin-7-glucuronide 1 Publications Verification Apigenin 7-O-glucuronide
Apigenin-7-glucuronide could inhibit Matrix Metalloproteinases (MMP) activities, with IC₅₀s of 12.87, 22.39, 17.52, 0.27 μM for MMP-3, MMP-8, MMP-9, MMP-13, respectively.

HY-136699

Excisanin A	Others	Cancer
Excisanin A is a potent anticancer agent. Excisanin A inhibits cell proliferation, migration, adhesion and invasion. Excisanin A decreases the expression of MMP-2, MMP-9, p-FAK, p-Src, integrin β1 protein. Excisanin A has the potential for the research of breast cancer .

HY-N7385

Nudol	MMP Apoptosis	Cancer
Nudol is a phenanthrene compound that has anti-cancer activity. Nudol inhibits cell proliferation, induces cell apoptosis. Nudol inhibits MMP-2M and *MMP-9* activity (K_i: 988.9 nM, 1.76 μM, respectively). Nudol can be used in the research of cancers, such as osteosarcoma .

HY-124373

ND-336	MMP	Metabolic Disease
ND-336 is a selective inhibitor of matrix metalloproteinase (MMP)-2, *MMP-9, and MMP-14, with K_i*s of 85, 150, and 120 nM, respectively. ND-336 accelerates diabetic wound healing in mice by lowering inflammation and by enhancing angiogenesis and re-epithelialization of the wound .

HY-124373A

(R)-ND-336	MMP	Metabolic Disease
(R)-ND-336 is a potent and selective *MMP-9* inhibitor with a K_i of 19 nM. (R)-ND-336 inhibits MMP-2 (K_i=127 nM) and MMP-14 (K_i=119 nM). (R)-ND-336 has the potential for diabetic foot ulcers (DFUs) research .

HY-116626

SM-7368	NF-κB p38 MAPK MMP	Cancer
SM-7368 is a potent NF-kB inhibitor that targets downstream of MAPK p38 activation . SM-7368 inhibits TNF-α-induced *MMP-9* upregulation. SM-7368 can be used for the research of chemotherapies targeting TNF-α-mediated tumor invasion and metastasis .

HY-131417

cis-ACCP	MMP	Infection Cardiovascular Disease Inflammation/Immunology Cancer
cis-ACCP is an orally active antimetastatic matrix metalloproteinase-2 (MMP-2) selective inhibitor. cis-ACCP can inhibit MMP-2 and MMP-9 with IC₅₀ values of 4 μM and 20 μM, respectively. cis-ACCP can be used for the research of a variety of chronic diseases .

HY-N0069

Solamargine 10+ Cited Publications Solamargin; δ-Solanigrine	P-glycoprotein Apoptosis	Cancer
Solamargine, a derivative from the steroidal solasodine in Solanum species, exhibits anticancer activities in numerous types of cancer. Solamargine induces non-selective cytotoxicity and P-glycoprotein inhibition. Solamargine significantly inhibits migration and invasion of HepG2 cells by down-regulating MMP-2 and MMP-9 expression and activity .

HY-147746

MMP2-IN-3	MMP	Cancer
MMP2-IN-3 (compound 2) is a potent MMP-2 (matrix metalloproteinases) inhibitor, with an IC₅₀ of 31 μM. MMP2-IN-3 also shows inhibitory activity against *MMP-9* and MMP-8, with IC₅₀ values of 26.6, and 32 μM, respectively .

HY-162079

Anticancer agent 183	MMP Apoptosis	Cancer
Anticancer agent 183 (compound 4h) inhibits the matrix metalloproteinase-9 (MMP-9) viability than 75% at 100 μg/mL. Anticancer agent 183 has anticancer activity with an IC₅₀ value of <0.14 μM on the A549 cell line. Anticancer agent 183 induces apoptotic .

HY-114785

BPHA	MMP	Cancer
BPHA is a potent and orally active MMP-2, *MMP-9* and MMP-14 inhibitor with IC₅₀s of 12 nM, 16 nM and 17 nM, respectively. BPHA does not inhibit MMP-1, -3, and -7 (the IC₅₀s are 974, >1000, and 795 nM, respectively). BPHA has antiangiogenic and antitumor effects .

HY-B1451

Imidapril hydrochloride TA-6366	Angiotensin-converting Enzyme (ACE) MMP	Cardiovascular Disease Metabolic Disease
Imidapril hydrochloride (TA-6366) is an orally active angiotensin-converting enzyme (ACE) and *MMP-9* inhibitor. Imidapril hydrochloride suppresses the conversion of angiotensin I to angiotensin II and thereby reduces total peripheral resistance and systemic blood pressure. Imidapril hydrochloride can be used for hypertension, type 1 diabetic, nephropathy and chronic heart failure research .

HY-N1463

Luteolin 7-O-glucuronide 1 Publications Verification Luteolin 7-glucuronide
Luteolin 7-O-glucuronide could inhibit Matrix Metalloproteinases (MMP) activities, with IC₅₀s of 17.63, 7.99, 11.42, 12.85, 0.03 μM for MMP-1, MMP-3, MMP-8, MMP-9, MMP-13, respectively .

HY-107394

UK 356618 4 Publications Verification	MMP	Inflammation/Immunology Cancer
UK 356618 (Compound 4j) is a potent and selective inhibitor of matrix metalloprotease-3 (MMP-3) with an IC₅₀ of 5.9 nM. UK 356618 is less potent against MMP-1, MMP-2, MMP-9, MMP-13 and MMP-14 compared with MMP-3 .

HY-112160

XL-784 free base	MMP	Cardiovascular Disease
XL-784 free base is a selective matrix metalloproteinases (MMP) inhibitor, with IC₅₀s of ~1900, 0.81, 120, 10.8, 18, 0.56 nM for MMP-1, MMP-2, MMP-3, MMP-8, MMP-9 and MMP-13, respectively .

HY-15768

Ilomastat Maximum Cited Publications 37 Publications Verification GM6001; Galardin	MMP	Cancer
Ilomastat (GM6001) is a potent and broad spectrum matrix metalloprotease (MMP) inhibitor, inhibits MMPs (IC₅₀s, 1.5 nM for MMP-1; 1.1 nM for MMP-2; 1.9 nM for MMP-3; 0.5 nM for MMP-9), with a K_i of 0.4 nM for human skin fibroblast collagenase (MMP-1).

HY-43586

BR351 precursor	MMP	Cancer
BR351 precursor is a precursor of BR351. BR351 is a brain penetrant MMP inhibitor with IC₅₀s of 4, 2, 11, 50 nM for MMP2, MMP8, MMP9 and MMP13, respectively .

HY-147867

MMP-2/9-IN-1	MMP	Cancer
MMP-2/9-IN-1 (Compound 4a) is a potent dual MMP-2 and *MMP-9* inhibitor with IC₅₀ values of 56 nM and 38 nM, respectively. MMP-2/9-IN-1 inhibits tumor growth, strongly induces cancer cell apoptosis, inhibits cell migration, and suppresses cell cycle progression leading to DNA fragmentation .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N6862

Lucideric acid A	Triterpenes Classification of Application Fields Terpenoids Source classification Polyporaceae Plants Disease Research Fields Cancer	MMP
Lucideric acid A is a natural compound isolated from Ganoderma lucidum, inhibits PMA-induced *MMP-9* activity, with anti-invasive effect on hepatoma cells .

HY-N2117

Isoginkgetin Maximum Cited Publications 12 Publications Verification	Structural Classification Flavonoids Ginkgoaceae Classification of Application Fields Source classification Phenols Polyphenols Plants Biflavones Ginkgo biloba Disease Research Fields Cancer	MMP Akt NF-κB Proteasome Apoptosis Autophagy
Isoginkgetin is a pre-mRNA splicing inhibitor inhibitor. Isoginkgetin also inhibits activities of both Akt, NF-κB and *MMP-9. Isoginkgetin inhibits* the activity of the 20S proteasome, induces apoptosis and activates autophagy .

HY-N10176

D-Isofloridoside	Cardiovascular Disease other families Classification of Application Fields Source classification Plants Disease Research Fields Saccharides	Reactive Oxygen Species MMP
D-Isofloridoside, one of the polysaccharide precursors, has the activity of scavenging free radicals, inhibiting ROS expression, and inhibiting MMP-2 and MMP-9 .

HY-N6860

Lucidenic acid C	Triterpenes Microorganisms Classification of Application Fields Terpenoids Source classification Polyporaceae Plants Disease Research Fields Cancer	MMP
Lucidenic acid C is a natural compound isolated from Ganoderma lucidum, inhibits PMA-induced *MMP-9* activity, with anti-invasive effect on hepatoma cells .

HY-136699

Excisanin A	Structural Classification Terpenoids Labiatae Source classification Diterpenoids Plants Baccharis densiflora Wedd.	Others
Excisanin A is a potent anticancer agent. Excisanin A inhibits cell proliferation, migration, adhesion and invasion. Excisanin A decreases the expression of MMP-2, MMP-9, p-FAK, p-Src, integrin β1 protein. Excisanin A has the potential for the research of breast cancer .

HY-N7385

Nudol	Orchidaceae Source classification Phenols Polyphenols Plants Epigeneium rotundatum (Lindl.) Summerh.	MMP Apoptosis
Nudol is a phenanthrene compound that has anti-cancer activity. Nudol inhibits cell proliferation, induces cell apoptosis. Nudol inhibits MMP-2M and *MMP-9* activity (K_i: 988.9 nM, 1.76 μM, respectively). Nudol can be used in the research of cancers, such as osteosarcoma .

HY-N0069

Solamargine 10+ Cited Publications Solamargin; δ-Solanigrine	Structural Classification Alkaloids Piperidine Alkaloids Solanum Classification of Application Fields Plants Solanaceae Disease Research Fields Saccharides Steroids Cancer	P-glycoprotein Apoptosis
Solamargine, a derivative from the steroidal solasodine in Solanum species, exhibits anticancer activities in numerous types of cancer. Solamargine induces non-selective cytotoxicity and P-glycoprotein inhibition. Solamargine significantly inhibits migration and invasion of HepG2 cells by down-regulating MMP-2 and MMP-9 expression and activity .

HY-113952

Actinonin 4 Publications Verification (-)-Actinonin	Infection Structural Classification Natural Products Microorganisms Classification of Application Fields Source classification Disease Research Fields	Aminopeptidase Bacterial MMP Apoptosis Antibiotic
Actinonin ((-)-Actinonin) is a naturally occurring antibacterial agent produced by Actinomyces. Actinonin inhibits aminopeptidase M, aminopeptidase N and leucine aminopeptidase. Actinonin is a potent reversible peptide deformylase (PDF) inhibitor with a K_i of 0.28 nM. Actinonin also inhibits MMP-1, MMP-3, MMP-8, *MMP-9, and hmeprin α* with K_i values of 300 nM, 1,700 nM, 190 nM, 330 nM, and 20 nM, respectively. Actinonin is an apoptosis inducer. Actinonin has antiproliferative and antitumor activities .

Cat. No.	Product Name	Chemical Structure

HY-B0099S

Edaravone-d5
Edaravone-d₅ is a deuterium labeled Edaravone. Edaravone is a strong novel free radical scavenger, and inhibits MMP-9-related brain hemorrhage in rats treated with tissue plasminogen activator[1][2][3][4].

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Mmp9 Inhibitors

Inhibitors & Agonists

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