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Isoforms Recommended:	MNK1

Results for "

Mnk1

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (3) Btk (1) Casein Kinase (1) Dengue virus (1) Eukaryotic Initiation Factor (eIF) (1) Flavivirus (1) MAPKAPK2 (MK2) (2) MNK (11) p38 MAPK (1) PD-1/PD-L1 (1) PI3K (1) VEGFR (1)
By Research Areas:	Cancer (12) Infection (2) Inflammation/Immunology (3) Metabolic Disease (1)

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Recombinant Proteins

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-139684

MNK1/2-IN-5

MNK Infection Inflammation/Immunology Cancer

MNK1/2-IN-5 is a potent and selective MNK1/2 inhibitor as a therapeutic agent.
HY-148105

DS12881479

MNK Cancer

DS12881479 is a potent and selective Mnk1 inhibitor with an IC₅₀ value of 21 nM. DS12881479 can be used in cancer research ^[1].
HY-112424

Tinodasertib

ETC-206
MNK Cancer

Tinodasertib (ETC-206) is a selective MNK1 and MNK2 inhibitor with IC₅₀s of 64 nM and 86 nM, respectively.

MNK1/2-IN-5	MNK	Infection Inflammation/Immunology Cancer
MNK1/2-IN-5 is a potent and selective *MNK1/2* inhibitor as a therapeutic agent.

DS12881479	MNK	Cancer
DS12881479 is a potent and selective *Mnk1* inhibitor with an IC₅₀ value of 21 nM. DS12881479 can be used in cancer research ^[1].

Tinodasertib ETC-206	MNK	Cancer
Tinodasertib (ETC-206) is a selective *MNK1* and *MNK2* inhibitor with IC₅₀s of 64 nM and 86 nM, respectively.

HY-146735

MNK1/2-IN-6	MNK Apoptosis	Cancer
MNK1/2-IN-6 is a potent and selective *MNK1/2* inhibitor with IC₅₀s of 2.3 nM and 3.4 nM for MNK1 and MNK2, respectively. MNK1/2-IN-6 induces apoptosis in a concentration-dependent manner ^[1].

HY-124638

MNK inhibitor 9	MNK	Cancer
MNK inhibitor 9 is a potent and selective inhibitor of *MNK1/2* with IC₅₀ values of 0.003 µM and 0.003 µM for *MNK1* and *MNK2* respectively. MNK inhibitor 9 has good cell permeability. MNK inhibitor 9 can be used in tumor related research ^[1].

HY-112113

SLV-2436

SEL201-88; SEL-201
MNK Cancer

SLV-2436 is a highly potent and ATP-competitive inhibitor of MNK1 and MNK2 with IC₅₀s of 10.8 nM and 5.4 nM, respectively.

SLV-2436 SEL201-88; SEL-201	MNK	Cancer
SLV-2436 is a highly potent and ATP-competitive inhibitor of *MNK1* and *MNK2* with IC₅₀s of 10.8 nM and 5.4 nM, respectively.

HY-156511

ETC-168	MNK	Cancer
ETC-168 is a selective and oral active *MNK* inhibitor with the IC₅₀ values of 23 and 43 nM against MNK1 and MNK2, respectively. ETC-168 shows antiproliferative efficacy in vivo and in vitro ^[1].

HY-10520

CGP 57380 4 Publications Verification	MNK Apoptosis	Cancer
CGP 57380 is a cell-permeable pyrazolo-pyrimidine compound that acts as a selective inhibitor of *Mnk1* with IC₅₀ of 2.2 μM, but has no inhibitory activity against p38, JNK1, ERK1/2, PKC, or Src-like kinases.

HY-131249

MK2-IN-3 2 Publications Verification	MAPKAPK2 (MK2)	Inflammation/Immunology
MK2-IN-3 is a potent and selective inhibitor of MAPKAP-K2 (MK-2), with an IC₅₀ of 8.5 nM. MK2-IN-3 shows selectivity for MK-2 over MK-3, MK-5, ERK2, MNK1, p38a (IC₅₀s=0.21, 0.081, 3.44, 5.7, and >100 μM, respectively) and MSK1, MSK2, CDK2, JNK2, IKK2 (IC₅₀s>200 μM). MK2-IN-3 can reduce TNFα production in both U937 cells and in vivo ^[1].

HY-146805

EB1	MNK Eukaryotic Initiation Factor (eIF) Apoptosis	Cancer
EB1 is the inhibitor of kinases *MNK* with IC₅₀s of 0.69 μM (MNK1) and 9.4 μM (MNK2). EB1 selectively inhibits the growth of cancer cells, but not normal cells. EB1 also increases cell apoptosis and suppresses eIF4E phosphorylation ^[1] .

HY-100022

Tomivosertib Maximum Cited Publications 6 Publications Verification eFT508	MNK PD-1/PD-L1	Cancer
Tomivosertib (eFT508) is a potent, highly selective, and orally active *MNK1* and *MNK2* inhibitor, with IC₅₀s of 1-2 nM against both isoforms. Tomivosertib (eFT508) treatment leads to a dose-dependent reduction in eIF4E phosphorylation at serine 209 (IC₅₀=2-16 nM) in tumor cell lines ^[1]. Tomivosertib (eFT508) also dramatically downregulates *PD-L1* protein abundance .

HY-112457

MK2-IN-3 hydrate 2 Publications Verification	MAPKAPK2 (MK2)	Inflammation/Immunology
MK2-IN-3 hydrate (compound 16) is an orally active, selective, and ATP-competitive MAPKAP-K2 (MK-2) inhibitor with an IC₅₀ of 0.85 nM.MK2-IN-3 hydrate is exceptional selectivity against MK-3 (IC₅₀=0.21 μM), MK-5 (IC₅₀=0.081 μM), ERK2 (IC₅₀=3.44 μM), MNK1(IC₅₀=5.7 μM) as well as CDK2, JNK2, IKK2, MSK1, and MSK2 ^[1].

HY-150612

(R)-STU104	p38 MAPK	Cancer
(R)-STU104 is a potent and orally active TAK1-MKK3 interaction inhibitor with IC₅₀s of 0.58 μM and 4.0 μM for TNF-α and MKK3 phosphorylation. (R)-STU104 suppresses the TAK1/MKK3/p38/MnK1/MK2/elF4E signal pathways through binding with MKK3 and disrupting the TAK1 phosphorylating MKK3. (R)-STU104 can be used for researching ulcerative colitis ^[1].

HY-124645

QL-X-138	Flavivirus Dengue virus Btk MNK	Infection Cancer
QL-X-138 is a potent and selective *BTK/MNK* dual kinase** inhibitor, exhibits covalent binding to BTK and non-covalent binding to MNK. QL-X-138 shows IC₅₀s of 9.4 nM, 107.4 nM and 26 nM for BTK, MNK1 and MNK2 kinases respectively. QL-X-138 also shows anti-dengue virus 2 activity, with an IC₅₀ of 3.5 μM. QL-X-138 can be used for the research of B-cell malignancies ^[1] .

HY-N3127

Orobol	Casein Kinase PI3K VEGFR	Metabolic Disease
Orobol is one of the major soy isoflavones and has various pharmacological activities, including anti-skin-aging and anti-obesity effects. Orobol inhibits *CK1ε, VEGFR2, MAP4K5, MNK1, MUSK, TOPK, and TNIK (IC₅₀=1.24-4.45* μM). Orobol also inhibits PI3K isoforms (IC₅₀=3.46-5.27 μM for PI3K α/β/γ/K/δ) ^[1] .

Orobol	Flavonoids Classification of Application Fields Leguminosae Glycine max (L.) merr Source classification Phenols Polyphenols Metabolic Disease Plants Disease Research Fields Isoflavones	Casein Kinase PI3K VEGFR
Orobol is one of the major soy isoflavones and has various pharmacological activities, including anti-skin-aging and anti-obesity effects. Orobol inhibits *CK1ε, VEGFR2, MAP4K5, MNK1, MUSK, TOPK, and TNIK (IC₅₀=1.24-4.45* μM). Orobol also inhibits PI3K isoforms (IC₅₀=3.46-5.27 μM for PI3K α/β/γ/K/δ) ^[1] .

Cat. No.	Compare	Product Name	Species	Source

HY-P701813

	MKNK1 Protein, Human (Sf9, GST) MKNK1; MAP kinase-interacting serine/threonine-protein kinase 1; MAP kinase signal-integrating kinase 1; MAPK signal-integrating kinase 1; Mnk1	Human	Sf9 insect cells
	MKNK1 (MAP Kinase Interacting Serine/Threonine Kinase 1) plays a central role in coordinating cellular responses to environmental stress and cytokines. It exerts regulatory control over translation processes by phosphorylating EIF4E, enhancing its affinity for mRNA cap structures with 7-methylguanosine. This highlights MKNK1's crucial involvement in finely tuning translation machinery in response to diverse cellular stimuli. MKNK1 Protein, Human (Sf9, GST) is the recombinant human-derived MKNK1 protein, expressed by Sf9 insect cells , with N-GST labeled tag. The total length of MKNK1 Protein, Human (Sf9, GST) is 424 a.a., .


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Mnk1

Inhibitors & Agonists

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