Search Result

Results for "

NF-kB

" in MCE Product Catalog:

By Targets:	NF-κB (315) Acyltransferase (12) ADC Cytotoxin (1) Adenosine Receptor (4) Adrenergic Receptor (2) AIM2 (1) Akt (22) AMPK (5) Amyloid-β (8) Androgen Receptor (1) Angiotensin-converting Enzyme (ACE) (1) Antibiotic (7) AP-1 (4) Apoptosis (101) Aryl Hydrocarbon Receptor (1) Autophagy (35) Bacterial (20) Bcl-2 Family (6) Biochemical Assay Reagents (1) c-Myc (1) Calcium Channel (6) Carbonic Anhydrase (1) Caspase (6) CCR (2) CDK (1) Chloride Channel (1) Cholinesterase (ChE) (1) COX (42) CXCR (3) Cytochrome P450 (2) Deubiquitinase (1) DNA/RNA Synthesis (4) E1/E2/E3 Enzyme (6) EGFR (2) Endogenous Metabolite (42) Epigenetic Reader Domain (3) ERK (23) Estrogen Receptor/ERR (2) Eukaryotic Initiation Factor (eIF) (1) FAK (1) Ferroptosis (9) Fungal (8) Glucocorticoid Receptor (4) GLUT (2) Gutathione S-transferase (3) HDAC (7) HIF/HIF Prolyl-Hydroxylase (2) Histone Acetyltransferase (2) Histone Demethylase (1) HIV (10) HSP (1) HSV (2) IAP (2) IGF-1R (1) IKK (17) Influenza Virus (7) Insulin Receptor (1) Interleukin Related (20) IRAK (1) Isotope-Labeled Compounds (1) JAK (6) JNK (13) Keap1-Nrf2 (14) Leukotriene Receptor (2) Lipoxygenase (1) MALT1 (2) MDM-2/p53 (1) MEK (8) mGluR (3) Microtubule/Tubulin (1) Mineralocorticoid Receptor (1) Mitochondrial Metabolism (3) Mitophagy (10) MMP (10) mTOR (3) MyD88 (2) Na+/K+ ATPase (1) nAChR (3) NO Synthase (17) NOD-like Receptor (NLR) (5) Nuclear Factor of activated T Cells (NFAT) (1) Opioid Receptor (2) P-glycoprotein (1) p38 MAPK (24) PAK (5) Parasite (11) PARP (1) PGE synthase (3) Phosphatase (1) Phosphodiesterase (PDE) (5) PI3K (3) PKA (1) PKC (4) Potassium Channel (1) PPAR (12) Progesterone Receptor (1) PROTACs (2) Proteasome (9) PTEN (1) Pyroptosis (1) Pyruvate Kinase (1) RANKL/RANK (1) Ras (1) Reactive Oxygen Species (16) Ribosomal S6 Kinase (RSK) (1) RIP kinase (2) SARS-CoV (1) Sirtuin (4) Sodium Channel (10) SphK (1) STAT (11) STING (3) TGF-beta/Smad (1) TGF-β Receptor (1) TNF Receptor (32) Toll-like Receptor (TLR) (12) Topoisomerase (1) TrxR (1) Tyrosinase (3) VEGFR (4) Virus Protease (2) Wnt (2) β-catenin (1)
By Research Areas:	Cancer (228) Cardiovascular Disease (45) Endocrinology (8) Infection (49) Inflammation/Immunology (306) Metabolic Disease (25) Neurological Disease (38)

By Targets:

NF-κB (315)

Acyltransferase (12)

ADC Cytotoxin (1)

Adenosine Receptor (4)

Adrenergic Receptor (2)

AIM2 (1)

Akt (22)

AMPK (5)

Amyloid-β (8)

Androgen Receptor (1)

Angiotensin-converting Enzyme (ACE) (1)

Antibiotic (7)

AP-1 (4)

Apoptosis (101)

Aryl Hydrocarbon Receptor (1)

Autophagy (35)

Bacterial (20)

Bcl-2 Family (6)

Biochemical Assay Reagents (1)

c-Myc (1)

Calcium Channel (6)

Carbonic Anhydrase (1)

Caspase (6)

CCR (2)

CDK (1)

Chloride Channel (1)

Cholinesterase (ChE) (1)

COX (42)

CXCR (3)

Cytochrome P450 (2)

Deubiquitinase (1)

DNA/RNA Synthesis (4)

E1/E2/E3 Enzyme (6)

EGFR (2)

Endogenous Metabolite (42)

Epigenetic Reader Domain (3)

ERK (23)

Estrogen Receptor/ERR (2)

Eukaryotic Initiation Factor (eIF) (1)

FAK (1)

Ferroptosis (9)

Fungal (8)

Glucocorticoid Receptor (4)

GLUT (2)

Gutathione S-transferase (3)

HDAC (7)

HIF/HIF Prolyl-Hydroxylase (2)

Histone Acetyltransferase (2)

Histone Demethylase (1)

HIV (10)

HSP (1)

HSV (2)

IAP (2)

IGF-1R (1)

IKK (17)

Influenza Virus (7)

Insulin Receptor (1)

Interleukin Related (20)

IRAK (1)

Isotope-Labeled Compounds (1)

JAK (6)

JNK (13)

Keap1-Nrf2 (14)

Leukotriene Receptor (2)

Lipoxygenase (1)

MALT1 (2)

MDM-2/p53 (1)

MEK (8)

mGluR (3)

Microtubule/Tubulin (1)

Mineralocorticoid Receptor (1)

Mitochondrial Metabolism (3)

Mitophagy (10)

MMP (10)

mTOR (3)

MyD88 (2)

Na+/K+ ATPase (1)

nAChR (3)

NO Synthase (17)

NOD-like Receptor (NLR) (5)

Nuclear Factor of activated T Cells (NFAT) (1)

Opioid Receptor (2)

P-glycoprotein (1)

p38 MAPK (24)

PAK (5)

Parasite (11)

PARP (1)

PGE synthase (3)

Phosphatase (1)

Phosphodiesterase (PDE) (5)

PI3K (3)

PKA (1)

PKC (4)

Potassium Channel (1)

PPAR (12)

Progesterone Receptor (1)

PROTACs (2)

Proteasome (9)

PTEN (1)

Pyroptosis (1)

Pyruvate Kinase (1)

RANKL/RANK (1)

Ras (1)

Reactive Oxygen Species (16)

Ribosomal S6 Kinase (RSK) (1)

RIP kinase (2)

SARS-CoV (1)

Sirtuin (4)

Sodium Channel (10)

SphK (1)

STAT (11)

STING (3)

TGF-beta/Smad (1)

TGF-β Receptor (1)

TNF Receptor (32)

Toll-like Receptor (TLR) (12)

Topoisomerase (1)

TrxR (1)

Tyrosinase (3)

VEGFR (4)

Virus Protease (2)

Wnt (2)

β-catenin (1)

By Research Areas:

Cancer (228)

Cardiovascular Disease (45)

Endocrinology (8)

Infection (49)

Inflammation/Immunology (306)

Metabolic Disease (25)

Neurological Disease (38)

454

Inhibitors & Agonists

Screening Libraries

Biochemical Assay Reagents

Peptides

224

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Targets Recommended: NF-κB

Cat. No.	Product Name	Target	Research Areas

HY-10072

SPC 839
NF-κB AP-1 Inflammation/Immunology

SPC 839 (compound 10) is an orally active inhibitor of AP-1 and NF-kB mediated transcriptional activation with IC₅₀ of 0.008 μM.

SPC 839	NF-κB AP-1	Inflammation/Immunology
SPC 839 (compound 10) is an orally active inhibitor of AP-1 and *NF-kB* mediated transcriptional activation with IC₅₀ of 0.008 μM.

HY-122881

HOIPIN-1 JTP-0819958	IKK	Cancer
HOIPIN-1 (JTP-0819958) is a selective linear ubiquitin chain assembly complex (LUBAC) inhibitor with an IC₅₀ of 2.8 μM. HOIPIN-1 suppress LUBAC-mediated NF-kB activation in vitro.

HY-N0277

Aconine
Jesaconine
NF-κB Inflammation/Immunology Cancer

Aconine inhibits receptor activator of nuclear factor (NF)-κB ligand (RANKL)-induced NF-κB activation.

Aconine Jesaconine	NF-κB	Inflammation/Immunology Cancer
Aconine inhibits receptor activator of nuclear factor (NF)-κB ligand (RANKL)-induced *NF-κB* activation.

HY-138537

NF-κB-IN-1	IKK	Cancer
NF-κB-IN-1, a 4-arylidene crucumin analogue, is a potent NF-κB signaling pathway inhibitor. NF-κB-IN-1 directly inhibits IKK to block NF-κB activation. NF-κB-IN-1 effectively inhibits the viability of lung cancer cells and attenuates the clonogenic activity of A549 cells.

HY-P1832

PTD-p65-P1 Peptide	NF-κB Apoptosis	Cancer Inflammation/Immunology
PTD-p65-P1 Peptide is a potent, selective nuclear transcription factor *NF-κB* inhibitor and derives from the p65 subunit of NF-κB amino acid residues 271-282, which selectively inhibits NF-κB activation induced by various inflammatory stimulation, down-regulate NF-κB-mediated gene expression and up-regulate apoptosis.

HY-13982

JSH-23	NF-κB	Cancer Metabolic Disease Inflammation/Immunology
JSH-23 is an *NF-κB* inhibitor which inhibits NF-κB transcriptional activity with an IC₅₀ of 7.1 μM in lipopolysaccharide (LPS)-stimulated macrophages RAW 264.7. JSH-23 inhibits nuclear translocation of NF-κB p65 without affecting IκBα degradation.

HY-149838

NF-κB-IN-9	NF-κB	Cancer
NF-κB-IN-9 is a nuclear factor kappa B (NF-κB) targeting sonosensitizer (λex/λem=489/628 nm). NF-κB-IN-9 exhibits strong inhibition on NF-κB signaling due to its two resveratrol units in one molecule. NF-κB-IN-9 has anti-tumor activity and shows remarkable sonocytotoxicity against cancer cells. NF-κB-IN-9 has biosafety in eenograft mice model.

HY-N0276

Flaconitine
Acetylaconitine; 3-Acetylaconitine
NF-κB Neurological Disease

Flaconitine is considered to be a NF-κB inhibitor.
HY-N0274

Caffeic acid phenethyl ester
NF-κB Apoptosis Cancer Inflammation/Immunology

Caffeic acid phenethyl ester is a NF-κB inhibitor.

Flaconitine Acetylaconitine; 3-Acetylaconitine	NF-κB	Neurological Disease
Flaconitine is considered to be a *NF-κB* inhibitor.

Caffeic acid phenethyl ester	NF-κB Apoptosis	Cancer Inflammation/Immunology
Caffeic acid phenethyl ester is a *NF-κB* inhibitor.

HY-P1832A

PTD-p65-P1 Peptide TFA	NF-κB Apoptosis	Cancer Inflammation/Immunology
PTD-p65-P1 Peptide TFA is a potent, selective nuclear transcription factor *NF-κB* inhibitor and derives from the p65 subunit of NF-κB amino acid residues 271-282, which selectively inhibits NF-κB activation induced by various inflammatory stimulation, down-regulate NF-κB-mediated gene expression and up-regulate apoptosis.

HY-144744

NF-κB-IN-3
NF-κB Cancer

NF-κB-IN-3 (Compound 2) is a NF-κB inhibitor with an IC₅₀ of 0.70 µM. NF-κB-IN-3 can be used as an antitumor agent.

NF-κB-IN-3	NF-κB	Cancer
NF-κB-IN-3 (Compound 2) is a *NF-κB* inhibitor with an IC₅₀ of 0.70 µM. NF-κB-IN-3 can be used as an antitumor agent.

HY-144765

NF-κB-IN-4	NF-κB Apoptosis	Inflammation/Immunology Neurological Disease
NF-κB-IN-4 (compound 17) is a potent and BBB-penetrated *NF-κB* pathway inhibitor with blood brain barrier (BBB) permeability. NF-κB-IN-4 exhibits potential anti-neuroinflammatory activity with low toxicity. NF-κB-IN-4 can block the activation and phosphorylation of IκBα, reduce expression of NLRP3, and thus inhibit NF-κB activation. NF-κB-IN-4 can be used for neuroinflammation related diseases research.

HY-142958

NF-κB-IN-2
NF-κB Neurological Disease

NF-κB-IN-2 inhibits TNF-α-induced canonical NF-κB signaling in PC-3 cells.

NF-κB-IN-2	NF-κB	Neurological Disease
NF-κB-IN-2 inhibits TNF-α-induced canonical NF-κB signaling in PC-3 cells.

HY-14645

(-)-DHMEQ Dehydroxymethylepoxyquinomicin	NF-κB	Cancer Inflammation/Immunology
(-)-DHMEQ (Dehydroxymethylepoxyquinomicin) is a potent, selective and irreversible *NF-κB* inhibitor that covalently binds to a cysteine residue. (-)-DHMEQ inhibits nuclear translocation of *NF-κB* and shows anti-inflammatory and anticancer activity.

HY-130994

Aeruginosin 865	NF-κB ADC Cytotoxin	Cancer Inflammation/Immunology
Aeruginosin 865, isolated from terrestrial cyanobacterium Nostoc sp. Lukešová 30/93, is the first aeruginosin-type peptide containing both a fatty acid and a carbohydrate moiety. Aeruginosin 865 inhibits translocation of *NF-kB* to the nucleus. Aeruginosin 865 has anti-inflammatory effect

HY-121012

(rac)-AG-205	NF-κB Akt	Endocrinology
(rac)-AG-205 is a potent inhibitor of progesterone receptor membrane component 1 (Pgrmc1) that induces genes involved in sterol synthesis, including the INSIG1 protein, which forms a complex with PGRMC1. (rac)-AG-205 prevents neuronal resistance to hypoxic ischaemia by blocking NF-kB signalling and activation of the BDNF/PI3K/AKT pathway.

HY-19498

WAY-204688 SIM-688	NF-κB	Inflammation/Immunology
WAY-204688 is an estrogen receptor (ER-α) selective, orally active inhibitor of *NF-κB* transcriptional activity with an IC₅₀ of 122 ± 30 nM for NF-κB-luciferase (NF-κB-luc) in HAECT-1 cells.

HY-P0151

SN50
NF-κB Inflammation/Immunology

SN50 is a cell permeable inhibitor of NF-κB translocation.
HY-14645B

DHMEQ racemate
rel-DHMEQ
NF-κB Cancer

DHMEQ racemate is a NF-κB inhibitor. DHMEQ racemate is less active than (-)-DHMEQ.
HY-17630

Edasalonexent
CAT-1004
NF-κB Metabolic Disease

Edasalonexent (CAT-1004) is an orally bioavailable NF-κB inhibitor.
HY-N0714A

Berbamine dihydrochloride
NF-κB Autophagy Apoptosis Cancer

Berbamine dihydrochloride is an inhibitor of NF-κB activity with remarkable anti-myeloma efficacy.
HY-N10357

3-Ethylthio withaferin A
Others Others

3-Ethylthio withaferin A is a derivative of Withaferin A. Withaferin A is a NF-kB inhibitor.
HY-N0441

Neferine
(-)-Neferine
NF-κB Autophagy Apoptosis Metabolic Disease Cancer

Neferine is a major bisbenzylisoquinline alkaloid. Neferine strongly inhibits NF-κB activation.

SN50	NF-κB	Inflammation/Immunology
SN50 is a cell permeable inhibitor of *NF-κB* translocation.

DHMEQ racemate rel-DHMEQ	NF-κB	Cancer
DHMEQ racemate is a *NF-κB* inhibitor. DHMEQ racemate is less active than (-)-DHMEQ.

Edasalonexent CAT-1004	NF-κB	Metabolic Disease
Edasalonexent (CAT-1004) is an orally bioavailable *NF-κB* inhibitor.

Berbamine dihydrochloride	NF-κB Autophagy Apoptosis	Cancer
Berbamine dihydrochloride is an inhibitor of *NF-κB* activity with remarkable anti-myeloma efficacy.

3-Ethylthio withaferin A	Others	Others
3-Ethylthio withaferin A is a derivative of Withaferin A. Withaferin A is a NF-kB inhibitor.

Neferine (-)-Neferine	NF-κB Autophagy Apoptosis	Metabolic Disease Cancer
Neferine is a major bisbenzylisoquinline alkaloid. Neferine strongly inhibits *NF-κB* activation.

HY-133987

AP-1/NF-κB activation inhibitor 1	NF-κB	Inflammation/Immunology
AP-1/NF-κB activation inhibitor 1 is a potent AP-1 and *NF-κB* mediated transcriptional activation inhibitor (IC₅₀=1 μM), without blocking basal transcription driven by the β-actin promoter. AP-1/NF-κB activation inhibitor 1 has a similar inhibitory effect on the production of IL-2 and IL-8 levels in stimulated cells.

HY-148475

NF-κB-IN-7	NF-κB	Cancer Infection Metabolic Disease Inflammation/Immunology Cardiovascular Disease
NF-κB-IN-7 (compound 1B) is a potent *NF-κB* inhibitor. NF-κB-IN-7 can be used for the research of cancer, inflammation, autoimmune diseases, diabetes and diabetes complications, infections, cardiovascular disease and defective reperfusion injury.

HY-147836

Akt/NF-κB/JNK-IN-1	Akt NF-κB JNK TNF Receptor COX	Inflammation/Immunology
Akt/NF-κB/JNK-IN-1 (Compound 2i) is an inhibitor of Akt, *NF-κB* and JNK signaling pathways. Akt/NF-κB/JNK-IN-1 inhibits nitric oxide production with an IC₅₀ of 3.15 μM. Akt/NF-κB/JNK-IN-1 shows anti-inflammatory activities.

HY-10172

IMD-0354 IKK2 Inhibitor V	IKK	Cancer
IMD-0354 (IKK2 Inhibitor V) is a selective IKKβ inhibitor which inhibits NF-κB activity. IMD0354 inhibits TNF-α induced NF-κB transcription activity with an IC₅₀ of 1.2 uM.

HY-N3796

Echinulin Echinuline	NF-κB	Inflammation/Immunology
Echinulin (Echinuline) is a cyclic dipeptide carrying a triprenylated indole moiety. Echinulin contributes to the activation of T cell subsets, which leads to *NF-κB* activation.Echinulin exerts its immune roles by the NF-κB pathway.Echinulin has the potential to serve as a immunotherapeutic agent.

HY-N6031

Dendrophenol
Moscatilin
NF-κB Cancer

Dendrophenol (Moscatilin) acts as a NF-κB inhibitor. Antineoplastic activity.
HY-N5048

Galloylpaeoniflorin
6'-O-Galloyl paeoniflorin
NF-κB Others

Galloylpaeoniflorin is a NF-κB inhibitor. And Galloylpaeoniflorin is a inhibitor of DNA cleavage.

Dendrophenol Moscatilin	NF-κB	Cancer
Dendrophenol (Moscatilin) acts as a *NF-κB* inhibitor. Antineoplastic activity.

Galloylpaeoniflorin 6'-O-Galloyl paeoniflorin	NF-κB	Others
Galloylpaeoniflorin is a *NF-κB* inhibitor. And Galloylpaeoniflorin is a inhibitor of DNA cleavage.

HY-N0191

Andrographolide Andrographis	NF-κB SARS-CoV Influenza Virus Autophagy Parasite	Cancer Infection Inflammation/Immunology
Andrographolide is a *NF-κB* inhibitor, which inhibits NF-κB activation through covalent modification of a cysteine residue on p50 in endothelial cells without affecting IκBα degradation or p50/p65 nuclear translocation. Andrographolide has antiviral effects.

HY-119970

Helenalin	NF-κB	Cancer Inflammation/Immunology
Helenalin is an anti-inflammatory sesquiterpene lactone. Helenalin selectively inhibits transcription factor *NF-κB* by directly targeting p65. Helenalin has alkylating activity, targets the cysteine sulfhydryl groups in the p65 subunit of NF-κB, thereby inhibits its DNA binding.

HY-124651

SEMBL	NF-κB MMP	Cancer Inflammation/Immunology
SEMBL is a potent *NF-κB* inhibitor. SEMBL can inhibit NF-κB-DNA binding, and also inhibits NF-κB-dependent inflammatory cytokine secretions. SEMBL inhibits cancer cell migration and invasion via decreasing MMP expression. SEMBL can be used for researching anticancer.

HY-14592

Tectochrysin
Techtochrysin; NSC 80687
NF-κB Cancer

Tectochrysin (Techtochrysin) is one of the major flavonoids of Alpinia oxyphylla Miquel. Tectochrysin inhibits activity of NF-κB.

Tectochrysin Techtochrysin; NSC 80687	NF-κB	Cancer
Tectochrysin (Techtochrysin) is one of the major flavonoids of Alpinia oxyphylla Miquel. Tectochrysin inhibits activity of *NF-κB*.

HY-18738

Pyrrolidinedithiocarbamate ammonium Ammonium pyrrolidinedithiocarbamate; PDTC ammonium; APDC	NF-κB	Inflammation/Immunology
Pyrrolidinedithiocarbamate ammonium (Ammonium pyrrolidinedithiocarbamate) is a selective and blood-brain barrier (BBB) permeable *NF-κB* inhibitor.

HY-139715

IMD-ferulic
NF-κB Cancer

IMD-ferulic is a covalently linked NF-κB modulator that improves the adjuvanticity of small molecule immune potentiators.

IMD-ferulic	NF-κB	Cancer
IMD-ferulic is a covalently linked *NF-κB* modulator that improves the adjuvanticity of small molecule immune potentiators.

HY-B0167A

Sodium Salicylate Salicylic acid sodium salt; 2-Hydroxybenzoic acid sodium salt	COX NF-κB Ribosomal S6 Kinase (RSK) Autophagy Apoptosis Endogenous Metabolite	Cancer Inflammation/Immunology
Sodium Salicylate (Salicylic acid sodium salt) inhibits cyclo-oxygenase-2 (COX-2) activity independently of transcription factor (NF-κB) activation. Sodium Salicylate is also a S6K inhibitor.Sodium Salicylate is a *NF-κB* inhibitor that decreases inflammatory gene expression and improves repair in aged muscle.

HY-147682

NF-κB-IN-5	NF-κB Apoptosis	Cancer
NF-κB-IN-5 (compound 4d) is an orally active and potent *NF-κB* inhibitor by interacting directly with NF-κB. NF-κB-IN-5 shows antitumor activity against human cancer cell lines (HCT116, U87-MG, HepG2, BGC823, PC9), with IC₅₀ values of 5.35, 2.81, 2.83, 2.02 and 3.90 μM, respectively. NF-κB-IN-5 induces apoptosis in U87-MG tumor cell and cell cycle arrest in G0/G1 phase.

HY-147972

NF-κB/MAPK-IN-1	NF-κB p38 MAPK NO Synthase COX	Inflammation/Immunology
NF-κB/MAPK-IN-1 (compound 11a) is a potent inhibitor of *NF-κB* and MAPK pathway. NF-κB/MAPK-IN-1 shows inhibitory activity against NO production, with an IC₅₀ of 6.96 µM. NF-κB/MAPK-IN-1 suppresses LPS-induced iNOS, COX-2, ERΚ and P38 signaling activation. NF-κB/MAPK-IN-1 can prevent LPS induced inflammatory response in macrophages. NF-κB/MAPK-IN-1 can be used for rheumatoid arthritis (RA) research.

HY-121632

Quinoclamine
NF-κB Cancer

Quinoclamine, a naphthoquinone derivative, is a NF-κB inhibitor. Quinoclamine exhibits anti-cancer activity.

Quinoclamine	NF-κB	Cancer
Quinoclamine, a naphthoquinone derivative, is a *NF-κB* inhibitor. Quinoclamine exhibits anti-cancer activity.

HY-147770

NF-κB-IN-6	NF-κB	Inflammation/Immunology
NF-κB-IN-6 (Compound 3d) is an anti-inflammatory agent through the mechanism of decreasing the protein expressions of iNOS and COX-2 by suppressing *NF-κB* signaling pathway. NF-κB-IN-6 inhibits NO production in LPS-induced RAW264.7 cells with an IC₅₀ of 23.1 μM.

HY-15530

CID-2858522
NF-κB Inflammation/Immunology Cancer

CID-2858522 is a highly potent and selective antigen receptor-mediated NF-κB activation inhibitor with an IC₅₀ of 70 nM.

CID-2858522	NF-κB	Inflammation/Immunology Cancer
CID-2858522 is a highly potent and selective antigen receptor-mediated *NF-κB* activation inhibitor with an IC₅₀ of 70 nM.

HY-114981

SRTCX1002	Sirtuin	Inflammation/Immunology
SRTCX1002 is a potent activator of SIRT1 (STAC), suppresses inflammatory responses through promotion of p65 deacetylation and inhibition of NF-κB Activity. SRTCX1002 suppresses stimuli-induced NF-κB transcriptional activation and LPS-induced TNFα secretion with IC₅₀s of 0.71 and 7.58 µM, respectively.

HY-14645A

(+)-DHMEQ (1R,2R,6R)-Dehydroxymethylepoxyquinomicin; (1R,2R,6R)-DHMEQ	Keap1-Nrf2	Inflammation/Immunology
(+)-DHMEQ is an activator of antioxidant transcription factor Nrf2. (+)-DHMEQ is the enantiomer of (-)-DHMEQ. (-)-DHMEQ inhibits NF-kB than its enantiomer (+)-DHMEQ.

HY-N0509

Astilbin	Keap1-Nrf2 TNF Receptor NF-κB	Inflammation/Immunology Cancer
Astilbin is a flavonoid compound and enhances NRF2 activation. Astilbin also suppresses TNF-α expression and *NF-κB* activation.

HY-124179

IT-901	NF-κB	Cancer
IT-901 is an orally active and potent NF-κB subunit c-Rel inhibitor with an IC₅₀ of 0.1 µM, 3 μM for NF-κB DNA binding and c-Rel DNA binding, respectively. IT-901, a bioactive naphthalenethiobarbiturate derivative, has the potential for human lymphoid tumors and ameliorate graft-versus-host disease (GVHD).

HY-116035

Nimbolide	NF-κB CDK Apoptosis	Cancer
Nimbolide is a triterpene derived from the leaves and flowers of neem (Azadirachta indica). Nimbolide induces apoptosis through inactivation of *NF-κB. Nimbolide inhibits CDK4/CDK6* kinase activity. Nimbolide suppresses the NF-κB, Wnt, PI3K-Akt, MAPK and JAK-STAT signaling pathways.

HY-N0694

Schisantherin A Gomisin-C; Schizantherin-A; Wuweizi ester-A	NF-κB	Inflammation/Immunology
Schisantherin A is a dibenzocyclooctadiene lignan. Schisantherin A inhibits *p65-NF-κB* translocation into the nucleus by IκBα degradation.

HY-78131B

(R)-(-)-Ibuprofen (R)-Ibuprofen	NF-κB	Inflammation/Immunology Cancer
(R)-(-)-Ibuprofen is the R enantiomer of Ibuprofen, inactive on COX, inhibits *NF-κB* activation; (R)-(-)-Ibuprofen exhibits anti-inflammatory and antinociceptive effects.

HY-144745

HSR1304	NF-κB	Cancer
HSR1304 (Compound 5d) is a potent inhibitor of *NFκB. The multifunctional transcription factor, nuclear factor-κB (NF-κB*), is broadly involved in multiple human diseases, such as cancer and chronic inflammation. HSR1304 has the potential for the research of cancer diseases.

HY-N10458

Asperbisabolane L	NF-κB	Inflammation/Immunology
Asperbisabolane L, a sesquiterpenoid, exerts the anti-inflammatory activity by inhibiting the *NF-κB*-activated pathway. Asperbisabolane L inhibits the translocation of NF-κB from cytoplasm to the nucleus. Asperbisabolane L also inhibits NO production in LPS-activated BV-2 microglia cells.

HY-N1987

Cucurbitacin IIb	Apoptosis	Inflammation/Immunology
Cucurbitacin IIb is an active component isolated from Hemsleya amabilis, induces apoptosis with anti-inflammatory activity. Cucurbitacin IIb inhibits phosphorylation of STAT3, JNK and Erk1/2, enhances the phosphorylation of IκB and NF-κB (p65), blocks nuclear translocation of NF-κB (p65) and decreases mRNA levels of IκBα and TNF-α.

HY-114519

Helenalin acetate	Histone Demethylase NF-κB	Cancer Inflammation/Immunology
Helenalin acetate, a natural *NF-κB* inhibitor, is a potent C/EBPβ inhibitor. Helenalin acetate has anti-inflammatory and anticancer activities.

HY-B0513

Methylthiouracil MTU	NF-κB TNF Receptor Interleukin Related ERK	Inflammation/Immunology Cancer
Methylthiouracil is an antithyroid agent. Methylthiouracil suppresses the production TNF-α and IL-6, and the activation of *NF-κB* and ERK1/2.

HY-N3625

Coronalolic acid Coronalonic acid	NF-κB	Inflammation/Immunology
Coronalolic acid, extract from the apical bud of Gardenia sootepenesis Hutch, inhibits TNF-α-induced *NF-κB* activity and NO production.

HY-N4231

Lucyoside B
NF-κB Inflammation/Immunology

Lucyoside B inhibits the production of inflammatory mediators via both NF-κB and activator protein-1 pathways in activated macrophages.

HY-119720

Neocryptotanshinone	NF-κB NO Synthase	Inflammation/Immunology
Neocryptotanshinone, a fatty diterpenoids from Salvia Miltiorrhiza, inhibits lipopolysaccharide-induced inflammation by suppression of *NF-κB* and iNOS signaling pathways.

HY-B1026

Adelmidrol	NF-κB COX PPAR	Inflammation/Immunology
Adelmidrol exerts important anti-inflammatory effects that are partly dependent on PPARγ. Adelmidrol reduces *NF-κB* translocation, and COX-2 expression.

HY-N11494

Dauricumine	NF-κB	Others
Dauricumine is a chlorinated alkaloid that inhibits NF-κB ligand-induced differentiation of mouse bone marrow-derived macrophages into multinucleated osteoclasts.

HY-10496

SC75741	NF-κB Influenza Virus	Infection Cancer
SC75741 is a broad and efficient *NF-κB* inhibitor with an IC₅₀ of 200 nM for p65. SC75741 blocks influenza viruses (IV) replication. SC75741 impairs DNA binding of the *NF-κB* subunit p65, resulting in reduced expression of cytokines, chemokines, and pro-apoptotic factors. SC75741 subsequently inhibits caspase activation and blocks caspase-mediated nuclear export of viral ribonucleoproteins.

HY-N8816

Stipuleanoside R2
NF-κB Inflammation/Immunology

Stipuleanoside R2 inhibits NF-κB activation stimulated by TNFα in a dose-dependent manner with IC₅₀ value of 4.1 μM.
HY-139024

ACAT-IN-7
Acyltransferase Inflammation/Immunology

ACAT-IN-7 is an acyl-Coenzyme A:cholesterol acyltransferase (ACAT) inhibitor. ACAT-IN-7 inhibits NF-κB mediated transcription.
HY-N10119

Ganoderterpene A
p38 MAPK Neurological Disease

Ganoderterpene A attenuates LPS-induced inflammation and apoptosis via suppressing MAPK and TLR-4/NF-κB pathways in BV-2 cells.

HY-N1380

Guaiacol 2-Methoxyphenol	COX NF-κB Endogenous Metabolite	Inflammation/Immunology
Guaiacol, a phenolic compound, inhibits LPS-stimulated COX-2 expression and *NF-κB* activation. Anti-inflammatory activity.

HY-139020

ACAT-IN-3
Acyltransferase Inflammation/Immunology

ACAT-IN-3 is an acyl-Coenzyme A:cholesterol acyltransferase (ACAT) inhibitor. ACAT-IN-3 inhibits NF-κB mediated transcription.

HY-N3497

Isochamaejasmin	NF-κB DNA/RNA Synthesis Parasite Apoptosis	Cancer Infection
Isochamaejasmin is a biflavonoid with anti-cancer, antiplasmodial and insecticidal activities. Isochamaejasmin displays a potent *NF-κB* (NF-κB) activation activity. Isochamaejasmin could cause DNA damage and induce apoptosis via the mitochondrial pathway in AW1 cells. Isochamaejasmin also has a moderate antiplasmodial activity (IC₅₀ of 7.3 μM for *P. falciparum*) and relatively low cytotoxicity (CC₅₀ of 29.0 μM).

HY-15122

Sinomenine	NF-κB Opioid Receptor Autophagy Apoptosis	Cancer Inflammation/Immunology Neurological Disease
Sinomenine, an alkaloid extracted from Sinomenium acutum, is a blocker of the *NF-κB* activation. Sinomenine also is an activator of μ-opioid receptor.

HY-121410

Narasin	Bacterial Apoptosis Parasite NF-κB Antibiotic	Cancer Infection
Narasin is a cationic ionophore and coccidiostat agent. Narasin inhibits *NF-κB* signaling and induces tumor cells apoptosis. Narasin has antimicrobial and anticancer activity.

HY-N0197

Baicalin Baicalein 7-O-β-D-glucuronide	NF-κB Autophagy HIV	Inflammation/Immunology Cancer
Baicalin, as a flavonoid glycoside, is an allosteric carnitine palmityl transferase 1 (CPT1) activator. Baicalin reduces the expression of *NF-κB*.

HY-B0167

Salicylic acid 2-Hydroxybenzoic acid	COX Autophagy Mitophagy Apoptosis Endogenous Metabolite	Inflammation/Immunology Cancer
Salicylic acid (2-Hydroxybenzoic acid) inhibits cyclo-oxygenase-2 (COX-2) activity independently of transcription factor (NF-κB) activation.

HY-103662

GW-870086	Glucocorticoid Receptor	Inflammation/Immunology Endocrinology
GW-870086 is a potent anti-inflammatory agent, acting as a glucocorticoid receptor agonist, with a pIC₅₀ of 10.1 in A549 cells expressing NF-κB.

HY-N0629

Maslinic acid Crategolic acid; 2α-Hydroxyoleanolic acid	NF-κB Bacterial HIV Endogenous Metabolite	Inflammation/Immunology Cancer
Maslinic acid can inhibit the DNA-binding activity of NF-κB p65 and abolish the phosphorylation of IκB-α, which is required for p65 activation.

HY-P1847

IKKγ NBD Inhibitory Peptide	NF-κB	Cancer
IKKγ NBD Inhibitory Peptide is a highly specific inhibitor *NF-κB* inhibitor. IKKγ NBD Inhibitory Peptide acts by disrupting the interaction between IKKγ/NEMO-binding domain (NBD) with IKKα and IKKβ, thus blocking TNF-α-induced NF-kB activation. IKKγ NBD Inhibitory Peptide could significantly suppresses inflammation and ameliorate the cerebral ischemia-induced neurological deficits.

HY-112671

CDDO-dhTFEA RTA dh404	Keap1-Nrf2 NF-κB	Inflammation/Immunology
CDDO-dhTFEA (RTA dh404) is a synthetic oleanane triterpenoid compound which potently activates Nrf2 and inhibits the pro-inflammatory transcription factor *NF-κB. CDDO-dhTFEA restores hypertension (MAP), increases Nrf2 and expression of its target genes, attenuates activation of NF-κB* and transforming growth factor-β pathways, and reduces glomerulosclerosis, interstitial fibrosis and inflammation in the chronic kidney disease (CKD) rats.

HY-12276

MALT1 inhibitor MI-2	MALT1	Cancer
MALT1 inhibitor MI-2 is a MALT1 inhibitor (IC₅₀=5.84 μM). MALT1 inhibitor MI-2 binds directly to MALT1, irreversibly suppresses protease function and is accompanied by NF-κB reporter activity suppression, c-REL nuclear localization inhibition, and NF-κB target gene downregulation. MALT1 inhibitor MI-2 shows nontoxic to animals.

HY-N1490

14-Deoxy-11,12-didehydroandrographolide 14-dehydro Andrographolide; AP10	NF-κB	Inflammation/Immunology Cancer
14-Deoxy-11,12-didehydroandrographolide is an analogue of Andrographolide. 14-Deoxy-11,12-didehydroandrographolide inhibits *NF-κB* activation.

HY-139025

ACAT-IN-8	Acyltransferase	Inflammation/Immunology
ACAT-IN-8 (example 206) is an acyl-Coenzyme A:cholesterol acyltransferase (ACAT) inhibitor. ACAT-IN-8 inhibits NF-κB mediated transcription.

HY-N0298

Stachydrine	NF-κB Endogenous Metabolite	Cardiovascular Disease Cancer
Stachydrine is a major constituent of Chinese herb leonurus heterophyllus sweet used to promote blood circulation and dispel blood stasis. Stachydrine can inhibit the *NF-κB* signal pathway.

HY-N2083

Handelin	NF-κB	Inflammation/Immunology
Handelin is a guaianolide dimer from Chrysanthemum boreale that has potent anti-inflammatory activity by down-regulating *NF-κB* signaling and pro-inflammatory cytokine production.

HY-15122A

Sinomenine hydrochloride Cucoline hydrochloride	NF-κB Opioid Receptor Autophagy Apoptosis	Cancer Inflammation/Immunology Neurological Disease
Sinomenine hydrochloride (Cucoline hydrochloride), an alkaloid extracted from Sinomenium acutum, is a blocker of the *NF-κB* activation. Sinomenine also is an activator of μ-opioid receptor.

HY-N0474

Tyrosol	NF-κB Endogenous Metabolite	Inflammation/Immunology
Tyrosol is a derivative of phenethyl alcohol. Tyrosol attenuates pro-inflammatory cytokines from cultured astrocytes and *NF-κB* activation. Anti-oxidative and anti-inflammatory effects.

HY-139021A

ACAT-IN-4 hydrochloride	Acyltransferase	Inflammation/Immunology
ACAT-IN-4 hydrochloride (Example 208) is an acyl-Coenzyme A:cholesterol acyltransferase (ACAT) inhibitor. ACAT-IN-4 hydrochloride inhibits NF-κB mediated transcription.

HY-139021

ACAT-IN-4	Acyltransferase	Inflammation/Immunology
ACAT-IN-4 (Example 208) is an acyl-Coenzyme A:cholesterol acyltransferase (ACAT) inhibitor. ACAT-IN-4 inhibits NF-κB mediated transcription.

HY-N0436

Engeletin	NF-κB	Infection Inflammation/Immunology
Engeletin is a flavanonol glycoside isolated from Smilax glabra Roxb. , inhibits *NF-κB* signaling-pathway activation, and possesses anti-inflammatory, analgesic, diuresis, detumescence, and antibiosis effects.

HY-N6046

Kamebakaurin	NF-κB	Cancer Inflammation/Immunology
Kamebakaurin is a natural compound isolated from Rabdosia excisa. Kamebakaurin is a potent inhibitor of *NF-κB* activation by directly targeting DNA-binding activity of p50.

HY-N2149A

Tomatidine hydrochloride	NF-κB JNK Autophagy Endogenous Metabolite	Inflammation/Immunology Cardiovascular Disease
Tomatidine hydrochloride acts as an anti-inflammatory agent by blocking *NF-κB* and JNK signaling. Tomatidine hydrochloride activates autophagy either in mammal cells or C elegans.

HY-N2149

Tomatidine	NF-κB JNK Autophagy Endogenous Metabolite	Inflammation/Immunology Cardiovascular Disease
Tomatidine acts as an anti-inflammatory agent by blocking *NF-κB* and JNK signaling. Tomatidine activates autophagy either in mammal cells or C elegans.

HY-15027

5-Aminosalicylic Acid Mesalamine; 5-ASA; Mesalazine	PPAR PAK NF-κB Endogenous Metabolite	Inflammation/Immunology Cancer
5-Aminosalicylic acid (Mesalamine) acts as a specific PPARγ agonist and also inhibits p21-activated kinase 1 (PAK1) and *NF-κB*.

HY-139022

ACAT-IN-5	Acyltransferase	Inflammation/Immunology
ACAT-IN-5 (example 19) is an acyl-Coenzyme A:cholesterol acyltransferase (ACAT) inhibitor. ACAT-IN-5 inhibits NF-κB mediated transcription.

HY-125911

Gossypin	NF-κB	Cancer Inflammation/Immunology Cardiovascular Disease
Gossypin is a flavone isolated from Hibiscus vitifolius and has antioxidant, antiinflammatory, anticancer, anticataract, antidiabetic, and hepatoprotective activities. Gossypin inhibits *NF-κB* and NF-κB-regulated gene expression. Gossypin inhibits RANKL-induced osteoclastogenesis both in mouse primary bone marrow cells and RAW 264.7 cells in vitro.

HY-N4182

Licochalcone E	Akt p38 MAPK Autophagy	Inflammation/Immunology
Licochalcone E, a flavonoid compound isolated from Glycyrrhiza uralensis, inhibits NF-κB and AP-1 transcriptional activity through the inhibition of AKT and MAPK activation.

HY-12212

Omaveloxolone RTA 408	Keap1-Nrf2 STING Apoptosis	Cancer Inflammation/Immunology
Omaveloxolone (RTA 408) is an antioxidant inflammation modulator (AIM), which activates Nrf2 and suppresses nitric oxide (NO). Omaveloxolone attenuates osteoclastogenesis by inhibiting STING dependent NF-κb signaling.

HY-U00450

4-O-Methyl honokiol	PPAR NF-κB	Cancer Inflammation/Immunology
4-O-Methyl honokiol is a natural neolignan isolated from Magnolia officinalis, acts as a PPARγ agonist, and inhibtis *NF-κB* activity, used for cancer and inflammation research.

HY-N0803

Myrcene
β-Myrcene
NF-κB Others

Myrcene (β-Myrcene), an aromatic volatile compound, suppresses TNFα-induced NF-κB activity. Myrcene has anti-invasive effect.

HY-10257

BAY 11-7085 BAY 11-7083	NF-κB Ferroptosis Apoptosis	Cancer
BAY 11-7085 (BAY 11-7083) is an inhibitor of *NF-κB* activation and phosphorylation of IκBα; it stabilizes IκBα with an IC₅₀ of 10 μM.

HY-N0708

Vanillic acid	NF-κB Bacterial Endogenous Metabolite	Infection Inflammation/Immunology
Vanillic acid is a flavoring agent found in edible plants and fruits, also found in Angelica sinensis. Vanillic acid inhibits *NF-κB* activation. Anti-inflammatory, antibacterial, and chemopreventive effects.

HY-112433

NIK SMI1	NF-κB	Inflammation/Immunology
NIK SMI1 is a potent, selective NF-κB inducing kinase (NIK) inhibitor, which inhibits NIK-catalyzed hydrolysis of ATP to ADP with IC₅₀ of 0.23±0.17 nM.

HY-N6812

Karacoline	NF-κB	Endocrinology
Karacoline, a diterpene alkaloid found in the plant Aconitum kusnezoffii, reduces degradation of the extracellular matrix (ECM) in intervertebral disc degeneration (IDD) via the NF-κB signaling pathway.

HY-122808

(-)-Camphoric acid	mGluR	Metabolic Disease
(-)-Camphoric acid is the less active enantiomer of Camphoric acid. Camphoric acid stimulates osteoblast differentiation and induces glutamate receptor expression. Camphoric acid also significantly induced the activation of NF-κB and AP-1.

HY-113509

Lipoxin A4 LXA4	Interleukin Related Endogenous Metabolite	Inflammation/Immunology
Lipoxin A4 (LXA4), an endogenous lipoxygenase-derived eicosanoid mediator, has potent dual pro-resolving and anti-inflammatory properties. Lipoxin A4 inhibits proliferation and inflammatory cytokine/chemokine production of human epidermal keratinocytes (NHEKs) associated with the ERK1/2 and NF-kB pathways. Lipoxin A4 inhibits serum amyloid A (SAA)-mediated IL-8 release with an IC₅₀ value of 25.74 nM.

HY-P1847A

IKKγ NBD Inhibitory Peptide TFA	NF-κB	Inflammation/Immunology
IKKγ NBD Inhibitory Peptide TFA is a highly specific inhibitor *NF-κB* inhibitor. IKKγ NBD Inhibitory Peptide TFA acts by disrupting the interaction between IKKγ/NEMO-binding domain (NBD) with IKKα and IKKβ, thus blocking TNF-α-induced NF-kB activation. IKKγ NBD Inhibitory Peptide TFA could significantly suppresses inflammation and ameliorate the cerebral ischemia-induced neurological deficits.

HY-N6673

Okanin	Toll-like Receptor (TLR) NF-κB	Inflammation/Immunology Neurological Disease Cardiovascular Disease
Okanin, effective constituent of the flower tea Coreopsis tinctoria, attenuates LPS-induced microglial activation through inhibition of the *TLR4/NF-κB* signaling pathways.

HY-113556

Sappanone A	NF-κB Keap1-Nrf2	Inflammation/Immunology
Sappanone A is a homoisoflavanone which exhibits anti-inflammatory effects via modulation of Nrf2 and *NF-κB*. Sappanone can attenuate allergic airway inflammation in Ovalbumin-induced asthma.

HY-B0289

Erdosteine RV 144	NF-κB Bacterial	Infection Metabolic Disease Inflammation/Immunology
Erdosteine inhibits lipopolysaccharide (LPS)-induced *NF-κB* activation. Erdosteine has muco-modulatory, anti-bacterial, anti-inflammatory and anti-oxidant effects.

HY-N1382

Asperuloside	NO Synthase	Inflammation/Immunology
Asperuloside is an iridoid isolated from Hedyotis diffusa, with anti-inflammatory activity. Asperuloside inhibits inducible nitric oxide synthase (iNOS), suppresses NF-κB and MAPK signaling pathways.

HY-N0622

Morusin Mulberrochromene	NF-κB STAT Bacterial	Cancer Infection Inflammation/Immunology
Morusin is a prenylated flavonoid isolated from Morus alba Linn. with various biological activities, such as antitumor, antioxidant, and anti-bacteria property. Morusin could inhibit *NF-κB* and STAT3 activity.

HY-117726

WAY-169916	Estrogen Receptor/ERR NF-κB	Inflammation/Immunology
WAY-169916 is a pathway-selective ligand of ER (estrogen receptor) that acts by inhibiting NF-kB transcriptional activity. WAY-169916 has potent anti-inflammatory effect.

HY-N6065

Praeruptorin A	NF-κB	Inflammation/Immunology
Praeruptorin A is a main bioactive constituent of Peucedanum praeruptorum (also known as Bai-Hua Qian Hu). Praeruptorin A exerts anti-inflammatory effects in vitro through inhibition of *NF-κB* activation.

HY-N0738

Stachydrine hydrochloride	NF-κB Endogenous Metabolite	Cardiovascular Disease Cancer
Stachydrine hydrochloride is the major active constituent of Leonurus artemisia, which is a potential therapy for cardiovascular diseases. Stachydrine can inhibit the *NF-κB* signal pathway. Anti-hypertrophic activities.

HY-13324

Bardoxolone methyl RTA 402; NSC 713200; CDDO Methyl ester	Keap1-Nrf2 Autophagy Apoptosis Ferroptosis	Cancer
Bardoxolone methyl (NSC 713200; RTA 402; CDDO Methyl ester) is a synthetic triterpenoid compound with potential antineoplastic and anti-inflammatory activities, acting as an activator of the Nrf2 pathway and an inhibitor of the *NF-κB* pathway.

HY-126382

Hesperidin methylchalcone	NF-κB	Inflammation/Immunology
Hesperidin methylchalcone (Hesperidin methyl chalcone) inhibits oxidative stress, cytokine production and *NF-κB* activation. Hesperidin methylchalcone inhibits inflammation and pain. Hesperidin methylchalcone exhibits vasoprotective activity.

HY-13735B

Quinacrine hydrochloride hydrate Mepacrine hydrochloride hydrate; SN-390 hydrochloride hydrate	Parasite Apoptosis Autophagy Mitophagy	Cancer Infection
Quinacrine hydrochloride hydrate (Mepacrine hydrochloride hydrate) is an antimalarial agent, which possess anticancer effect both in vitro and vivo. Quinacrine hydrochloride hydrate suppresses NF-κB and activates p53 signaling, which results in the induction of the apoptosis.

HY-N2065

Withaferin A	NF-κB Ferroptosis	Cancer Inflammation/Immunology
Withaferin A is a steroidal lactone isolated from Withania somnifera, inhibits *NF-kB* activation and targets vimentin, with potent antiinflammatory and anticancer activities. Withaferin A is an inhibitor of endothelial protein C receptor (EPCR) shedding.

HY-N0208

Kaempferol-3-O-glucorhamnoside	p38 MAPK NF-κB	Inflammation/Immunology
Kaempferol-3-O-glucorhamnoside, a flavonoid derived from plant Thesium chinense Turcz, inhibits inflammatory responses via MAPK and NF-κB pathways in vitro and in vivo.

HY-18935A

CBL0137 hydrochloride Curaxin-137 hydrochloride; CBL-C137 hydrochloride	MDM-2/p53 NF-κB	Cancer
CBL0137 hydrochloride is an inhibitor of the histone chaperone, FACT. CBL0137 hydrochloride can also activate p53 and inhibits *NF-κB* with EC₅₀s of 0.37 and 0.47 µM, respectively.

HY-W001174

2,5-Dihydroxyacetophenone	ERK NF-κB	Inflammation/Immunology
2,5-Dihydroxyacetophenone, isolated from Rehmannia glutinosa, inhibits the production of inflammatory mediators in activated macrophages by blocking the ERK1/2 and *NF-κB* signaling pathways.

HY-N1410

Triacetylresveratrol	STAT NF-κB	Cancer
Triacetylresveratrol, an acetylated analog of Resveratrol. Triacetylresveratrol decreases the phosphorylation of STAT3 and *NF-κB* in a dose- and time- dependent manner in PANC-1 and BxPC-3 cells. Anticancer effects.

HY-N0452

Hyperoside	Influenza Virus Fungal NF-κB Apoptosis	Cancer Infection Inflammation/Immunology
Hyperoside is a *NF-κB* inhibitor, found from Hypericum monogynum. Hyperoside shows anti-tumor, antifungal, anti-inflammatory, anti-viral, and anti-oxidative activities, and can induce apoptosis.

HY-N0907

Ginsenoside Rg6	NF-κB Apoptosis	Cancer Inflammation/Immunology
Ginsenoside Rg6 inhibits TNF-α-induced *NF-κB* transcriptional activity with an IC₅₀ of 29.34 μM in HepG2 cells. Ginsenoside Rg6 also exhibits apoptosis-inducing effect.

HY-78131BS

(R)-(-)-Ibuprofen-d3 (R)-Ibuprofen-d₃	NF-κB	Inflammation/Immunology Cancer
(R)-(-)-Ibuprofen-d₃ is the deuterium labeled (R)-(-)-Ibuprofen. (R)-(-)-Ibuprofen is the R enantiomer of Ibuprofen, inactive on COX, inhibits NF-κB activation; (R)-(-)-Ibuprofen exhibits anti-inflammatory and antinociceptive effects.

HY-N0773

Isovitexin Saponaretin; Homovitexin	JNK NF-κB	Inflammation/Immunology
Isovitexin is a flavonoid isolated from passion flower, Cannabis and, and the palm, possesses anti-inflammatory and anti-oxidant activities; Isovitexin acts like a JNK1/2 inhibitor and inhibits the activation of *NF-κB*.

HY-107352

Fosfenopril Fosinoprilat; Fosinoprilic acid; SQ 27519	Angiotensin-converting Enzyme (ACE) Toll-like Receptor (TLR) NF-κB TNF Receptor Interleukin Related	Inflammation/Immunology Cardiovascular Disease
Fosfenopril (Fosinoprilat) is a potent angiotensin converting enzyme (ACE) inhibitor. Fosfenopril alleviates lipopolysaccharide (LPS)-induced inflammation by inhibiting *TLR4/NF-κB* signaling in monocytes.

HY-32735

Triptolide PG490	NF-κB Apoptosis	Cancer
Triptolide is a diterpenoid triepoxide extracted from the root of Tripterygium wilfordii with immunosuppressive, anti-inflammatory, antiproliferative and antitumour effects. Triptolide is a *NF-κB* activation inhibitor.

HY-N1949

Homoplantaginin	TNF Receptor NF-κB	Inflammation/Immunology
Homoplantaginin is a flavonoid from a traditional Chinese medicine Salvia plebeia with antiinflammatory and antioxidant properties. Homoplantaginin could inhibit TNF-α and IL-6 mRNA expression, IKKβ and *NF-κB* phosphorylation.

HY-B0167S

Salicylic acid-d6 2-Hydroxybenzoic acid-d₆	COX Autophagy Mitophagy Apoptosis	Cancer Inflammation/Immunology
Salicylic acid-d₆ is a deuterium labeled Salicylic acid. Salicylic acid inhibits cyclo-oxygenase-2 (COX-2) activity independently of transcription factor (NF-κB) activation[1].

HY-136512

Streptazolin	Antibiotic	Infection Inflammation/Immunology
Streptazolin is an antibiotic. Streptazolin increases bacterial killing and elaboration of immunostimulatory cytokines by macrophages in vitro. Streptazolin stimulates the macrophage NF-κB pathway via PI3K signaling.

HY-13735A

Quinacrine dihydrochloride Mepacrine dihydrochloride; SN-390 dihydrochloride	Parasite Apoptosis Autophagy Mitophagy	Cancer Infection
Quinacrine (Mepacrine) dihydrochloride is an orally bioavailable antimalarial agent, which possess anticancer effect both in vitro and vivo. Quinacrine dihydrochloride suppresses NF-κB and activate p53 signaling, which results in the induction of the apoptosis.

HY-N0044

Ginsenoside Re Ginsenoside B2; Panaxoside Re; Sanchinoside Re	Amyloid-β NF-κB JNK Endogenous Metabolite	Inflammation/Immunology Neurological Disease Cancer
Ginsenoside Re (Ginsenoside B2) is an extract from Panax notoginseng. Ginsenoside Re decreases the β-amyloid protein (Aβ). Ginsenoside Re plays a role in antiinflammation through inhibition of JNK and *NF-κB*.

HY-N0052A

Sanguinarine chloride Sanguinarin chloride; Sanguinarium chloride; Pseudochelerythrine chloride	Apoptosis Autophagy Bacterial Parasite	Cancer
Sanguinarine (Sanguinarin) chloride, a benzophenanthridine alkaloid derived from the root of Sanguinaria Canadensis, can stimulate apoptosis via activating the production of reactive oxygen species (ROS). Sanguinarine-induced apoptosis is associated with the activation of JNK and NF-κB.

HY-14655

Sulfasalazine NSC 667219	NF-κB Autophagy Apoptosis Ferroptosis Bacterial Antibiotic	Cancer Infection Inflammation/Immunology
Sulfasalazine (NSC 667219) is an anti-rheumatic agent for the research of rheumatoid arthritis and ulcerative colitis. Sulfasalazine can suppress *NF-κB* activity. Sulfasalazine is a type 1 ferroptosis inducer.

HY-N1380S1

Guaiacol-d3 2-Methoxyphenol-d₃	COX NF-κB	Inflammation/Immunology
Guaiacol-d₃ is the deuterium labeled Guaiacol. Guaiacol, a phenolic compound, inhibits LPS-stimulated COX-2 expression and NF-κB activation. Guaiacol has an anti-inflammatory activity[1].

HY-18937

WEHI-345	RIP kinase	Cancer
WEHI-345 is a potent and selective RIPK2 kinase inhibitor with an IC₅₀ of 0.13 μM, which delays RIPK2 ubiquitylation and *NF-κB* activation on oligomerization domain (NOD) stimulation.

HY-N6826

Asatone	NF-κB	Inflammation/Immunology
Asatone is an active component isolated from Radix et Rhizoma Asari, with anti-inflammatory effect via activation of NF-κB and donwn regulation of p-MAPK (ERK, JNK and p38) pathways.

HY-142100

Licoagrochalcone C	NF-κB	Inflammation/Immunology
Licoagrochalcone C, a flavonoid, reveals efficacious inhibitory activity on *NF-κB* transcription. Licoagrochalcone C shows significant inhibitory activity on LPS (HY-D1056)-induced NO production.

HY-N0052

Sanguinarine Sanguinarin; Sanguinarium; Pseudochelerythrine	Apoptosis Autophagy	Cancer
Sanguinarine (Sanguinarin), a benzophenanthridine alkaloid derived from the root of Sanguinaria Canadensis, can stimulate apoptosis via activating the production of reactive oxygen species (ROS). Sanguinarine-induced apoptosis is associated with the activation of JNK and NF-κB.

HY-N2682A

(E)-Dehydrodiconiferyl alcohol	Carbonic Anhydrase	Cancer
(E)-Dehydrodiconiferyl alcohol behaves as good hCA IX and hCA XII dual inhibitors. And (E)-Dehydrodiconiferyl alcohol suppresses the *NF-κB* nuclear translocation in connective tissue of healing area.

HY-13812

QNZ EVP4593	NF-κB TNF Receptor	Inflammation/Immunology Neurological Disease
QNZ (EVP4593) shows strong inhibitory effects on *NF-κB* transcriptional activation and TNF-α production with IC₅₀s of 11 and 7 nM, respectively. QNZ (EVP4593) is a neuroprotective inhibitor of SOC channel.

HY-13425

Deguelin (-)-Deguelin; (-)-cis-Deguelin	Akt Autophagy Apoptosis	Cancer
Deguelin, a naturally occurring rotenoid, acts as a chemopreventive agent by blocking multiple pathways like PI3K-Akt, IKK-NF-κB, and MAPK-mTOR-survivin-mediated apoptosis. Deguelin binding to Hsp90 leads to a decreased expression of numerous oncogenic proteins, including MEK1/2, Akt, HIF1α, COX-2, and NF-κB.

HY-112108

Chitosan oligosaccharide COS	AMPK Endogenous Metabolite	Cancer Metabolic Disease
Chitosan oligosaccharide (COS) is an oligomer of β-(1→4)-linked D-glucosamine. Chitosan oligosaccharide (COS) activates AMPK and inhibits inflammatory signaling pathways including *NF-κB* and MAPK pathways.

HY-145439

Colistin adjuvant-1	Bacterial NF-κB	Infection
Colistin adjuvant-1 is a colistin adjuvant, shows increased colistin potentiation activity against Gram-negative bacteria. Colistin adjuvant-1 inhibits *NF-κB* with an IC₅₀ of 0.209 μM.

HY-W067427

BAY32-5915
IKK Cancer

BAY32-5915 is a potent IKKα inhibitor with an IC₅₀ value of 60 nM. BAY32-5915 has not affect Doxorubicin (HY-15142A)-induced NF-κB activation.

HY-N2585

Isodeoxyelephantopin	Reactive Oxygen Species NF-κB Autophagy	Cancer
Isodeoxyelephantopin is a sesquiterpene lactone isolated from Elephantopus scaber. Isodeoxyelephantopin induces ROS generation, suppresses NF-κB activation. Isodeoxyelephantopin also modulates LncRNA expression and exhibit activities against breast cancer.

HY-N2477

Taraxerol	Apoptosis NF-κB	Cancer Inflammation/Immunology
Taraxerol is isolated from Taraxacum mongolicum, and has anti-inflammtory and anti-cancer effects. Taraxerol attenuates acute inlammation through inhibition of *NF-κB* signaling pathway. Taraxerol induces cell apoptosis.

HY-139019

ACAT-IN-2	Acyltransferase	Inflammation/Immunology
ACAT-IN-2 is an acyl-Coenzyme A:cholesterol acyltransferase (ACAT) inhibitor extracted from patent EP1236468A1, example 187. ACAT-IN-2 inhibits NF-κB mediated transcription.

HY-N0847

Micheliolide	NF-κB	Others
Micheliolide could effectively attenuate the high glucose-stimulated activation of NF-κB, the degradation of IκBα, and the expression of MCP-1, TGF-β1 and FN in rat mesangial cells (MCs).

HY-N2119

Sciadopitysin	NF-κB	Inflammation/Immunology
Sciadopitysin is a type of biflavonoids in leaves from ginkgo biloba. Sciadopitysi inhibits RANKL-induced osteoclastogenesis and bone loss by inhibiting *NF-κB* activation and reducing the expression of c-Fos and NFATc1.

HY-N0220

Dauricine	NF-κB Apoptosis	Cancer Inflammation/Immunology
Dauricine, a bisbenzylisoquinoline alkaloid in Menispermum dauricum, possesses anti-inflammatory activity. Dauricine inhibits cell proliferation and invasion, and induces apoptosis by suppressing *NF-κB* activation in a dose- and time-dependent manner in colon cancer.

HY-139026

ACAT-IN-9	Acyltransferase	Inflammation/Immunology
ACAT-IN-9 is an acyl-Coenzyme A:cholesterol acyltransferase (ACAT) inhibitor extracted from patent EP1236468A1, example 207. ACAT-IN-9 inhibits NF-κB mediated transcription.

HY-N0250

Saikosaponin D	STAT NF-κB Estrogen Receptor/ERR Bacterial	Cancer Infection Inflammation/Immunology
Saikosaponin D is a triterpene saponin isolated from Bupleurum, with anti-inflammatory, anti-bacterial, anti-tumor, and anti-allergic activities; Saikosaponin D inhibits selectin, STAT3 and *NF-kB* and activates estrogen receptor-β.

HY-N0819

Raddeanin A	Apoptosis	Cancer
Raddeanin A is a natural triterpenoid saponin component of Anemone raddeana, with anti-cancer activities. Raddeanin A exerts anticancer effect on human osteosarcoma via the ROS/JNK and NF-κB signal pathway.

HY-N0141

Parthenolide (-)-Parthenolide	NF-κB Autophagy Mitophagy Apoptosis	Cancer
Parthenolide is a sesquiterpene lactone found in the medicinal herb Feverfew. Parthenolide exhibits anti-inflammatory activity by inhibiting *NF-κB* activation; also inhibits HDAC1 protein without affecting other class I/II HDACs.

HY-N2497

Isoliquiritin apioside	NF-κB MMP p38 MAPK	Cancer
Isoliquiritin apioside significantly decreases PMA-induced increases in MMP9 activities and suppresses PMA-induced activation of MAPK and *NF-κB*. Isoliquiritin apioside auppresseses invasiveness and angiogenesis of cancer cells and endothelial cells.

HY-N0290

Mangiferin	NF-κB Keap1-Nrf2 Apoptosis	Cancer
Mangiferin is a Nrf2 activator. Mangiferin suppresses nuclear translocation of the *NF-κB* subunits p65 and p50. Mangiferin exhibits antioxidant, antidiabetic, antihyperuricemic, antiviral, anticancer and antiinflammatory activities.

HY-N1098

Velutin	HIF/HIF Prolyl-Hydroxylase	Inflammation/Immunology
Velutin is an aglycone extracted from Flammulina velutipes, with inhibitory activity against melanin biosynthesis. Velutin reduces osteoclast differentiation and down-regulates HIF-1α through the NF-κB pathway.

HY-N0170

Indole-3-carbinol I3C; 3-Indolemethanol	NF-κB Aryl Hydrocarbon Receptor E1/E2/E3 Enzyme Endogenous Metabolite	Cancer
Indole-3-carbinol (I3C) inhibits *NF-κB* activity and also is an Aryl hydrocarbon receptor (AhR) agonist, and an inhibitor of WWP1 (WW domain-containing ubiquitin E3 ligase 1).

HY-N1380S

Guaiacol-d7 2-Methoxyphenol-d₇	COX NF-κB Endogenous Metabolite	Inflammation/Immunology
Guaiacol-d₇ is the deuterium labeled Guaiacol[1]. Guaiacol, a phenolic compound, inhibits LPS-stimulated COX-2 expression and NF-κB activation[1]. Anti-inflammatory activity[2].

HY-N0906

Ginsenoside Rk3	NF-κB	Inflammation/Immunology Cardiovascular Disease
Ginsenoside Rk3 is present in the roots Panax ginseng herbs. Ginsenoside Rk3 significantly inhibits TNF-α-induced *NF-κB* transcriptional activity, with an IC₅₀ of 14.24±1.30 μM in HepG2 cells.

HY-16172

DMAPT Dimethylamino Parthenolide	NF-κB	Cancer
DMAPT (Dimethylamino Parthenolide), an analogue of Parthenolide (PTL), is an oral active *NF-κB* inhibitor, with a LD₅₀ of 1.7 μM for cell population in AML cells. Has potential anti-cancer and anti-metastatic effect.

HY-139027

ACAT-IN-10	Acyltransferase	Inflammation/Immunology
ACAT-IN-10 is an acyl-Coenzyme A:cholesterol acyltransferase (ACAT) inhibitor extracted from patent EP1236468A1, example 197. ACAT-IN-10 weakly inhibits NF-κB mediated transcription.

HY-N0802

Tenuigenin Senegenin	NF-κB Bacterial	Infection Inflammation/Immunology
Tenuigenin is a major active component isolated from the root of the Chinese herb Polygala tenuifolia. Tenuigenin protects against S.aureus-induced pneumonia by inhibiting *NF-κB* activation. Tenuigenin has anti-inflammatory effect.

HY-N0608

Myrislignan	NF-κB	Inflammation/Immunology
Myrislignan, a lignan isolated from Myristica fragrans Houtt, possesses anti-inflammatory activities. Myrislignan attenuates LPS-induced inflammation reaction in murine macrophage cells through inhibition of NF-kB signalling pathway activation.

HY-N3188

Niloticin	Akt NF-κB	Infection
Niloticin, tetracyclic triterpenoid compound, is a osteoclastogenesis inhibitor. Niloticin shows anti-viral, antioxidative, and mosquitocidal activities. Niloticin inhibits osteoclastogenesis by blocking RANKL-RANK interaction and suppressing the AKT, MAPK, and *NF-κB* signaling pathways.

HY-139027A

ACAT-IN-10 dihydrochloride	Acyltransferase	Inflammation/Immunology
ACAT-IN-10 dihydrochloride is an acyl-Coenzyme A:cholesterol acyltransferase (ACAT) inhibitor extracted from patent EP1236468A1, example 197. ACAT-IN-10 dihydrochloride weakly inhibits NF-κB mediated transcription.

HY-139023

ACAT-IN-6	Acyltransferase	Inflammation/Immunology
ACAT-IN-6 is an acyl-Coenzyme A:cholesterol acyltransferase (ACAT) inhibitor extracted from patent EP1236468A1, example 200. ACAT-IN-6 potently inhibits NF-κB mediated transcription.

HY-N1404

Sodium aescinate	NF-κB	Cancer Inflammation/Immunology
Sodium aescinate is a triterpene saponin derived from Aesculus hippocastanum seeds, with anti-inflammatory and antioxidant activities. Sodium aescinate inhibits hepatocellular carcinoma growth by targeting CARMA3/NF-κB pathway.

HY-N1380S3

Guaiacol-d4 2-Methoxyphenol-d₄	COX NF-κB Endogenous Metabolite	Inflammation/Immunology
Guaiacol-d₄ is the deuterium labeled Guaiacol[1]. Guaiacol, a phenolic compound, inhibits LPS-stimulated COX-2 expression and NF-κB activation[1]. Anti-inflammatory activity[2].

HY-N0316

Mollugin	NF-κB Reactive Oxygen Species Apoptosis VEGFR c-Myc	Cancer
Mollugin is an orally active and potent *NF-κB* inhibitor. Mollugin induces S-phase arrest of HepG2 cells, and increased intracellular reactive oxygen species (ROS) levels. Mollugin induces DNA damage in HepG2 cells, as well as an increase in the expression of p-H2AX. Mollugin shows anti-cancer effect by inhibiting TNF-α-induced NF-κB activation. Mollugin enhances the osteogenic action of BMP-2 (bone morphogenetic protein 2) via the p38-Smad signaling pathway.

HY-151262

JAK-IN-23	JAK STING NF-κB STAT	Inflammation/Immunology
JAK-IN-23 is an orally active double inhibitor of JAK/STAT and NF-κB. JAK-IN-23 can inhibit JAK1/2/3 with IC₅₀ values of 8.9 nM, 15 nM and 46.2 nM, respectively. JAK-IN-23 has potent inhibitory activities against interferon-stimulated genes (ISG) and NF-κB pathways with IC₅₀ values of 3.3 nM and 150.7 nM, respectively. JAK-IN-23 has great anti-inflammatory that decreases the release of various proinflammatory factors. JAK-IN-23 can be used for the research of inflammatory bowel disease (IBD).

HY-N1380S4

Guaiacol-d4-1 2-Methoxyphenol-d₄-1	COX NF-κB Endogenous Metabolite	Inflammation/Immunology
Guaiacol-d₄-1 is the deuterium labeled Guaiacol[1]. Guaiacol, a phenolic compound, inhibits LPS-stimulated COX-2 expression and NF-κB activation[1]. Anti-inflammatory activity[2].

HY-W011474

Geranylgeraniol	NF-κB	Inflammation/Immunology
Geranylgeraniol is an orally acitve vitamin K₂ sub-type, an intermediate of the mevalonate pathway. Geranylgeraniol targets *NF-kB* signaling pathway and could alleviate LPS-induced microglial inflammation in animal model.

HY-122521

Sootepin D	NF-κB	Inflammation/Immunology
Sootepin D (compound 6), a triterpene from the apical bud of Gardenia sootepensis, inhibits TNF-α-induced *NF-κB* activity with an IC₅₀ of 8.3μM. Sootepin D has anti-inflammatory activity.

HY-N1380S2

Guaiacol-13C6 2-Methoxyphenol-¹³C₆	COX NF-κB Endogenous Metabolite	Inflammation/Immunology
Guaiacol-¹³C₆ is the ¹³C labeled Guaiacol[1]. Guaiacol, a phenolic compound, inhibits LPS-stimulated COX-2 expression and NF-κB activation[1]. Anti-inflammatory activity[2].

HY-100538

DTP3	DNA/RNA Synthesis JAK	Cancer
DTP3 TFA is a potent and selective GADD45β/MKK7 inhibitor. DTP3 TFA targets an essential, cancer-selective cell-survival module downstream of the NF-κB pathway.

HY-N0375

18α-Glycyrrhetinic acid	Proteasome NF-κB Apoptosis	Cancer Inflammation/Immunology Neurological Disease
18α-Glycyrrhetinic acid, a diet-derived compound, is an inhibitor of *NF-kB* and an activator of proteasome, which serves as pro-longevity and anti-aggregation factor in a multicellular organism. 18α-Glycyrrhetinic acid induces apoptosis.

HY-N2117

Isoginkgetin	MMP Akt NF-κB Proteasome Apoptosis Autophagy	Cancer Inflammation/Immunology
Isoginkgetin is a pre-mRNA splicing inhibitor inhibitor. Isoginkgetin also inhibits activities of both Akt, *NF-κB* and MMP-9. Isoginkgetin inhibits the activity of the 20S proteasome, induces apoptosis and activates autophagy.

HY-107593

PS-1145 dihydrochloride	IKK	Inflammation/Immunology
PS-1145 (dihydrochloride) is a potent IκB kinase-2 inhibitor with an IC₅₀ value of 88 nM. PS-1145 (dihydrochloride) inhibits activity of NF-κB by blocking IκB kinase phosphorylation in tumor-bearing rats.

HY-N0001

(-)-Epicatechin (-)-Epicatechol; Epicatechin; epi-Catechin	COX Ferroptosis Endogenous Metabolite	Cancer Inflammation/Immunology
(-)-Epicatechin inhibits cyclooxygenase-1 (COX-1) with an IC₅₀ of 3.2 μM. (-)-Epicatechin inhibits the IL-1β-induced expression of iNOS by blocking the nuclear localization of the p65 subunit of NF-κB.

HY-N1333

Rubioncolin C	NF-κB	Cancer
Rubioncolin C exerts anti-tumor activity by inducing apoptotic and autophagic Cell Death and inhibiting the *NF-κB* and Akt/mTOR/P70S6K Pathway in Human Cancer Cells.

HY-119931

2-Hydroxychalcone	Bcl-2 Family Apoptosis NF-κB Parasite	Cancer Metabolic Disease
2-hydroxychalcone, a natural flavonoid, is a potent antioxidant, inhibiting lipid peroxidation. 2-Hydroxychalcone induces apoptosis by Bcl-2 downregulation. 2-Hydroxychalcone inhibits the activation of NF-kB.

HY-N0589

Dehydrodiisoeugenol	NF-κB COX Bacterial	Infection Inflammation/Immunology
Dehydrodiisoeugenol is isolated from Myristica fragrans Houtt, shows anti-inflammatory and anti-bacterial actions. Dehydrodiisoeugenol inhibits LPS- stimulated *NF-κB* activation and cyclooxygenase (COX)-2 gene expression in murine macrophages.

HY-N6893

Ergolide	NF-κB	Inflammation/Immunology
Ergolide is a sesquiterpene lactone isolated from the dried flowers of Inula Britannica. Ergolide inhibits inducible nitric oxide synthase and cyclo-oxygenase-2 expression in RAW 264.7 macrophages through the inactivation of *NF-κB*.

HY-N0039

Ginsenoside Rb1 Gypenoside III	Na+/K+ ATPase IRAK NF-κB Autophagy Mitophagy HSV	Inflammation/Immunology Cancer
Ginsenoside Rb1, a main constituent of the root of Panax ginseng, inhibits Na⁺, K⁺-ATPase activity with an IC₅₀ of 6.3±1.0 μM. Ginsenoside also inhibits IRAK-1 activation and phosphorylation of NF-κB p65 .

HY-N0499

Cyanidin Chloride IdB 1027	RANKL/RANK	Cancer
Cyanidin Chloride (IdB 1027), a subclass of anthocyanin, displays antioxidant and anti-carcinogenesis properties. Cyanidin Chloride (IdB 1027) inhibits osteoclast formation, hydroxyapatite resorption, and receptor activator of NF-κB ligand (RANKL)-induced osteoclast marker gene expression.

HY-N4187

Licochalcone D	NF-κB Apoptosis Reactive Oxygen Species	Cancer Metabolic Disease Inflammation/Immunology
Licochalcone D, a flavonoid compound mainly existing in the root of Glycyrrhiza uralensis, is a potent and orally active inhibitor of *NF-kappaB (NF-κB) p65*. Licochalcone D possesses antioxidant, anti-inflammatory, anti-cancer properties.

HY-149248

NF-κB-IN-8	NF-κB	Inflammation/Immunology
NF-κB-IN-8 competitively antagonizes LPS binding to MD-2. NF-κB-IN-8 reduces the expression of inflammatory factors by binding to MD-2. NF-κB-IN-8 also inhibits ALP activity. NF-κB-IN-8 can be used for the research of inflammation such as acute lung injury (ALI).

HY-13453

BAY 11-7082 BAY 11-7821	IKK Deubiquitinase Autophagy Apoptosis NF-κB	Cancer Inflammation/Immunology
BAY 11-7082 is an IκBα phosphorylation and *NF-κB* inhibitor. BAY 11-7082 selectively and irreversibly inhibits the TNF-α-induced phosphorylation of IκB-α, and decreases NF-κB and expression of adhesion molecules. BAY 11-7082 inhibits ubiquitin-specific protease USP7 and USP21 (IC₅₀=0.19, 0.96 μM, respectively). BAY 11-7082 inhibits gasdermin D (GSDMD) pore formation in liposomes and inflammasome-mediated pyroptosis and IL-1β secretion in human and mouse cells.

HY-N10009

Cudraflavone B	NF-κB TNF Receptor COX ERK p38 MAPK Sirtuin	Inflammation/Immunology
Cudraflavone B is a prenylated flavonoid with anti-inflammatory and anti-tumor properties. Cudraflavone B is also a dual inhibitor of COX-1 and COX-2. Cudraflavone B blocks the translocation of nuclear factor κB (NF-κB) from the cytoplasm to the nucleus in macrophages. Thus, Cudraflavone B inhibits tumor necrosis factor α (TNFα) gene expression and secretion. Cudraflavone B also triggers the mitochondrial apoptotic pathway, activates NF-κB, the MAPK p38, and ERK, and induced the expression of SIRT1. Thus Cudraflavone B inhibits the growth of human oral squamous cell carcinoma cells.

HY-113919

Nothofagin	Calcium Channel	Inflammation/Immunology
Nothofagin, a dihydrochalcone, is isolated from rooibos (Aspalathus linearis). Nothofagin downregulates NF-κB translocation through blocking calcium influx. Nothofagin has antioxidant activity and ameliorates various inflammatory responses such as the septic response and vascular inflammation.

HY-120231

Z-VRPR-FMK	MALT1	Cancer
Z-VRPR-FMK is an irreversible MALT1 protein inhibitor. Z-VRPR-FMK inhibits the growth and invasion of diffuse large B-cell lymphoma by inhibiting MALT1-induced NF-κB activation and MMP expression.

HY-N0608A

(Rac)-Myrislignan	NF-κB	Inflammation/Immunology
(Rac)-Myrislignan is the racemate of Myrislignan. Myrislignan, a lignan isolated from Myristica fragrans Houtt, possesses anti-inflammatory activities. Myrislignan attenuates LPS-induced inflammation reaction in murine macrophage cells through inhibition of NF-kB signalling pathway activation.

HY-N0896

Inulicin 1-O-Acetylbritannilactone	NF-κB COX	Cancer Inflammation/Immunology
Inulicin (1-O-Acetylbritannilactone) is an active compound that inhibits VEGF-mediated activation of Src and FAK. Inulicin (1-O-Acetylbritannilactone) inhibits LPS-induced PGE₂ production and COX-2 expression, and *NF-κB* activation and translocation.

HY-10454

Delanzomib CEP-18770	Proteasome NF-κB Apoptosis	Cancer
Delanzomib (CEP-18770) is a potent and orally active chymotrypsin-like activity of the proteasome inhibitor with an IC₅₀ of 3.8 nM. Delanzomib inhibits *NF-κB* activity, induces cancer cell apoptotic, and has strong antiangiogenic and anti-cancer activities.

HY-N0045

Ginsenoside Rg1 Panaxoside A; Panaxoside Rg1	Amyloid-β NF-κB Apoptosis	Inflammation/Immunology Neurological Disease Cancer
Ginsenoside Rg1 is one of the major active components of Panax ginseng. Ginsenoside Rg1 ameliorates the impaired cognitive function, displays promising effects by reducing cerebral Aβ levels. Ginsenoside Rg1 also reduces *NF-κB* nuclear translocation.

HY-N8085

Icariside F2	NF-κB	Inflammation/Immunology
Icariside F2 is a potent *NF-κB* inhibitor with an IC₅₀ value of 16.25 μM. Icariside F2 is an aromatic glycoside isolated from the leaves of E. ulmoides Oliver. Icariside F2 has anti-inflammatory activity.

HY-146058

NF-κB/PON1-IN-1	NF-κB Reactive Oxygen Species	Cancer
NF-κB/PON1-IN-1 (Compound 16) is a *NF-κB/PON1* pathway inhibitor. NF-κB/PON1-IN-1 has antioxidant (IC₅₀ = 45.76 µM) and hepatoprotective activities.

HY-130603

DCZ0415	NF-κB Apoptosis	Cancer
DCZ0415, a potent TRIP13 inhibitor, impairs nonhomologous end joining repair and inhibits *NF-κB* activity. DCZ0415 induces anti-myeloma activity in vitro, in vivo, and in primary cells derived from drug-resistant myeloma patients.

HY-N0222

Avicularin	COX NF-κB PPAR ERK GLUT Apoptosis	Cancer Infection Inflammation/Immunology Neurological Disease
Avicularin is an orally active flavonoid. Avicularin inhibits NF-κB (p65), COX-2 and PPAR-γ activities. Avicularin has anti-inflammatory, anti-infectious anti-allergic, anti-oxidant, hepatoprotective, and anti-tumor activities.

HY-50937

ST 2825	MyD88	Inflammation/Immunology
ST 2825 is a specific MyD88 dimerization inhibitor. ST2825 interferes with recruitment of IRAK1 and IRAK4 by MyD88, causing inhibition of IL-1β-mediated activation of NF-κB transcriptional activity.

HY-B0289S

Erdosteine-13C4 RV 144-¹³C₄	NF-κB Bacterial	Infection Metabolic Disease Inflammation/Immunology
Erdosteine-¹³C₄ is a ¹³C-labeled Erdosteine. Erdosteine inhibits lipopolysaccharide (LPS)-induced NF-κB activation[1][2]. Erdosteine has muco-modulatory, anti-bacterial, anti-inflammatory and anti-oxidant effects[3].

HY-N10358

3-(2-Hydroxyethyl) thio withaferin A	NF-κB	Others
3-(2-Hydroxyethyl) thio withaferin A is a Withaferin A derivative. Withaferin A, a steroidal lactone, inhibits NF-kB activation and targets vimentin, with potent antiinflammatory and anticancer activities. Withaferin A is an inhibitor of endothelial protein C receptor (EPCR) shedding.

HY-151970

STING-IN-4	STING	Inflammation/Immunology
STING-IN-4 (Compound 1) is a STING inhibitor that inhibits STING expression and hence reducing activation of STING and nuclear factor-κB (NF-κB) signaling. STING-IN-4 shows anti-inflammatory activity and can be used for the research of sepsis.

HY-N0758

Barlerin 8-O-Acetyl shanzhiside methyl ester	NF-κB	Inflammation/Immunology
Barlerin (8-O-Acetyl shanzhiside methyl ester) is an iridoid glucoside isolated from the leaves of Lamiophlomis rotata Kudo, a Chinese folk medicinal plant in Xi-zang. Barlerin (8-O-Acetyl shanzhiside methyl ester) could inhibt *NF-κB*.

HY-147562

ALPK1-IN-2	NF-κB	Cancer Inflammation/Immunology
ALPK1-IN-2 (compound T001) is a potent ALPK1 (alpha-kinase 1) inhibitor, with an IC₅₀ of 95 nM. ALPK1-IN-2 also inhibits *NF-κB, with an IC₅₀* of 1.31 μM.

HY-32735S

Triptolide-d3 PG490-d₃	NF-κB Apoptosis	Cancer
Triptolide-d₃ is the deuterium labeled Triptolide. Triptolide is a diterpenoid triepoxide extracted from the root of Tripterygium wilfordii with immunosuppressive, anti-inflammatory, antiproliferative and antitumour effects. Triptolide is a NF-κB activation inhibitor[1][2][3][4][5][6].

HY-152089

SB26019	Microtubule/Tubulin	Inflammation/Immunology Neurological Disease
SB26019 is a potent anti-neuroinflammatory agent. SB26019 regulates NF-κB activation by inducing monomeric α-tubulin formation. SB26019-induced α-tubulin monomer inhibits p65 translocation.

HY-B0808A

Oxaprozin potassium Oxaprozinum potassium; Wy21743 potassium	COX NF-κB Akt IKK Apoptosis	Cancer Inflammation/Immunology
Oxaprozin potassium is an orally active and potent COX inhibitor, with IC₅₀ values of 2.2 μM for human platelet COX-1 and and 36 μM for IL-1-stimulated human synovial cell COX-2, respectively. Oxaprozin potassium also inhibits the activation of *NF-κB. Oxaprozin potassium induces cell apoptosis. Oxaprozin potassium shows anti-inflammatory activity. Oxaprozin potassium-mediated inhibition of the Akt/IKK/NF-κB* pathway contributes to its anti-inflammatory properties.

HY-B0808

Oxaprozin Oxaprozinum; Wy21743	COX NF-κB Akt IKK Apoptosis	Inflammation/Immunology Cancer
Oxaprozin is an orally active and potent COX inhibitor, with IC₅₀ values of 2.2 μM for human platelet COX-1 and and 36 μM for IL-1-stimulated human synovial cell COX-2, respectively. Oxaprozin also inhibits the activation of *NF-κB. Oxaprozin induces cell apoptosis. Oxaprozin shows anti-inflammatory activity. Oxaprozin-mediated inhibition of the Akt/IKK/NF-κB* pathway contributes to its anti-inflammatory properties.

HY-A0068

Aurothioglucose Gold thioglucose	NF-κB HIV Reactive Oxygen Species	Cancer Infection Inflammation/Immunology
Aurothioglucose (Gold thioglucose), containing monovalent gold ion, is a potent active-site inhibitor of TrxR1 (thioredoxin reductase 1), with an IC₅₀ of 65 nM. Aurothioglucose inhibits the DNA binding of NF-κB in vitro. Aurothioglucose shows anti-HIV and anti-rheumatic activities.

HY-N0029

Forsythoside B	TNF Receptor NF-κB	Inflammation/Immunology
Forsythoside B is a phenylethanoid glycoside isolated from Forsythia suspensa (Thunb.) Vahl, a Chinese folk medicinal plant for treating inflammatory diseases and promoting blood circulation. Forsythoside B could inhibit TNF-alpha, IL-6, IκB and modulate *NF-κB*.

HY-109017

Vamorolone VBP15	Glucocorticoid Receptor Mineralocorticoid Receptor NF-κB	Inflammation/Immunology
Vamorolone (VBP15) is a first-in-class, orally active dissociative steroidal anti-inflammatory agent and membrane-stabilizer. Vamorolone improves muscular dystrophy without side effects. Vamorolone shows potent *NF-κB* inhibition and substantially reduces hormonal effects.

HY-14655S

Sulfasalazine-d4	NF-κB Autophagy Apoptosis Ferroptosis Bacterial Antibiotic	Cancer Infection Inflammation/Immunology
Sulfasalazine-d₄ is the deuterium labeled Sulfasalazine. Sulfasalazine (NSC 667219) is an anti-rheumatic agent for the research of rheumatoid arthritis and ulcerative colitis. Sulfasalazine can suppress NF-κB activity. Sulfasalazine is a type 1 ferroptosis inducer[1][2][3][4].

HY-N7980

Rubipodanone A	NF-κB	Cancer
Rubipodanone A, a naphthohydroquinone dimer, shows cytotoxicity against A549, BEL-7402, HeLa, HepG2, SGC-7901 and U251 cells. Rubipodanone A also shows obvious activating effect at 20 and 40 μM for NF-κB.

HY-122961

Dehydromiltirone 1,2-Didehydromiltirone	NF-κB p38 MAPK	Inflammation/Immunology
Dehydromiltirone (1,2-Didehydromiltirone) is a diterpenoid quinone with an anti-inflammatory effect. Dehydromiltirone prevents liver injury by modifying the MAPK and *NF-κB* signaling pathways, reducing neuroinflammatory responses, and inhibiting platelet aggregation. Dehydromiltirone can be used for osteoporosis research.

HY-114335

Triphala	NF-κB Fungal	Cancer Infection Inflammation/Immunology
Triphala, an Ayurvedic polyherbal formulation comprising of equiproportional fruit parts of Terminalia chebula, Terminalia bellerica, and Phyllanthus emblica. Triphala inhibits *NF-κB* activation. Triphala exerts antifungal action. Anti-adipogenic, anti-inflammatory, and anti-neoplastic activities.

HY-N0119

Naringin Dihydrochalcone Naringin DC	NF-κB	Cancer
Naringin Dihydrochalcone is an artificial sweetener derived from naringin. Naringin is a major flavanone glycoside obtained from tomatoes, grapefruits, and many other citrus fruits. Naringin exhibits biological properties such as antioxidant, anti-inflammatory, and antiapoptotic activities. Naringin suppresses *NF-κB* signaling pathway.

HY-15027S

5-Aminosalicylic Acid-D3 hydrochloride Mesalamine-d₃ (hydrochloride); 5-ASA-d₃ (hydrochloride); Mesalazine-d₃ (hydrochloride)	PPAR PAK NF-κB Endogenous Metabolite	Inflammation/Immunology Cancer
5-Aminosalicylic Acid-d₃ (hydrochloride) is the deuterium labeled 5-Aminosalicylic Acid. 5-Aminosalicylic acid (Mesalamine) hydrochloride acts as a specific PPARγ agonist and also inhibits p21-activated kinase 1 (PAK1) and NF-κB.

HY-100112

WEHI-345 analog	RIP kinase	Others
WEHI-345 analog is the analog of WEHI-345. WEHI-345 is a potent and selective RIPK2 kinase inhibitor with an IC₅₀ of 0.13 μM, which delays RIPK2 ubiquitylation and NF-κB activation on oligomerization domain (NOD) stimulation.

HY-100581

CORM-3	NF-κB NOD-like Receptor (NLR)	Inflammation/Immunology
CORM-3, a carbon monoxide-releasing molecule, attenuates NF-κB p65 nuclear translocation, reduces ROS generation and enhances intracellular glutathione and superoxide dismutase levels. CORM-3 reduces NLRP3 inflammasome activation.

HY-N2101

Benzoyloxypaeoniflorin	Tyrosinase NF-κB	Inflammation/Immunology
Benzoyloxypaeoniflorin, isolated from the root of Paeonia suffruticosa, is a tyrosinase inhibitor against mushroom tyrosinase with IC₅₀ of 0.453 mM. Benzoyloxypaeoniflorin is *NF-κB* Inhibitor and contributes to improving blood circulation through its inhibitory effect on both platelet aggregation and blood coagulation.

HY-N10175

Berkeleyacetal C	Fungal Endogenous Metabolite	Inflammation/Immunology
Berkeleyacetal C, a meroterpenoid compound, shows favorable activity of inhibiting nitrogen oxide (NO) production of macrophages stimulated by lipopolysaccharide (LPS). Berkeleyacetal C exerts anti-inflammatory effects via inhibiting NF-κB, ERK1/2 and IRF3 signaling pathways.

HY-N4327

Eurycomalactone	NF-κB Apoptosis Akt Bcl-2 Family	Infection Inflammation/Immunology
Eurycomalactone is an active quassinoid could be isolated from Eurycoma longifolia Jack. Eurycomalactone is a potent *NF-κB* inhibitor with an IC₅₀ value of 0.5 μM. Eurycomalactone inhibits protein synthesis and depletes cyclin D1. Eurycomalactone enhances radiosensitivity through arrest cell cycle at G2/M phase and delayed DNA double-strand break repair. Eurycomalactone inhibits the activation of AKT/NF‑κB signaling, induces apoptosis and enhances chemosensitivity to Cisplatin (HY-17394).

HY-N10768

1-Dehydro-[10]-gingerdione	IKK NF-κB	Inflammation/Immunology
1-Dehydro-[10]-gingerdione directly inhibits IKKβ activity by targeting the activation loop of IKKβ, thus disrupting IKKβ-catalysed IκBα phosphorylation in macrophages stimulated with agonists. 1-Dehydro-[10]-gingerdione inhibits LPS (HY-D1056)-induced *NF-κB* transcriptional activity. 1-Dehydro-[10]-gingerdione has the potential for NF-κB-associated inflammation and autoimmune disorders research.

HY-N0908

Ginsenoside Rg5	IGF-1R NF-κB COX	Cancer Inflammation/Immunology Cardiovascular Disease Endocrinology
Ginsenoside Rg5 is the main component of Red ginseng. Ginsenoside blocks binding of IGF-1 to its receptor with an IC₅₀ of ~90 nM. Ginsenoside Rg5 also inhibits the mRNA expression of COX-2 via suppression of the DNA binding activities of NF-κB p65.

HY-N0592A

Demethyleneberberine chloride	NF-κB AMPK	Cancer Infection Inflammation/Immunology
Demethyleneberberine chloride is a natural mitochondria-targeted antioxidant. Demethyleneberberine chloride alleviates mice colitis and inhibits the inflammatory responses by inhibiting *NF-κB* pathway and regulating the balance of Th cells. Demethyleneberberine chloride could serve as a AMPK activator for treating non-alcoholic fatty liver disease (NAFLD).

HY-W041489

Chelidonic acid	NF-κB Caspase	Inflammation/Immunology Cancer
Chelidonic acid is a component of Chelidonium majus L., used as an antimicrobial. Chelidonic acid also shows anti-inflammatory activity. Chelidonic acid has potential to inhibit IL-6 production by blocking *NF-κB* and caspase-1. Chelidonic acid is a glutamate decarboxylase inhibitor, with a K_i of 1.2 μM.

HY-N1956

Rubiadin-1-methyl ether	NF-κB	Metabolic Disease
Rubiadin-1-methyl ether is a natural anthraquinone isolated from Morinda officinalis How, and inhibits osteoclastic bone resorption via inhibition on the phosphorylation of NF-κB p65 and the degradation of IκBα as well as decrease in the nuclear translocation of p65.

HY-N2819

Adenanthin	NF-κB	Cancer Inflammation/Immunology
Adenanthin is an inhibitor of thiol-dependent antioxidant enzymes, targeting to Prx 1 and Prx 2. Adenanthin impairs human natural killer (NK) cells effector functions, and killing hepatocellular carcinoma cells. Adenanthin inhibits *NF-κB* signaling and lipogenesis and the development of obesity by regulating ROS.

HY-N0592

Demethyleneberberine	NF-κB AMPK	Metabolic Disease Inflammation/Immunology
Demethyleneberberine is a natural mitochondria-targeted antioxidant. Demethyleneberberine alleviates mice colitis and inhibits the inflammatory responses by inhibiting *NF-κB* pathway and regulating the balance of Th cells. Demethyleneberberine could serve as a AMPK activator for treating non-alcoholic fatty liver disease (NAFLD).

HY-N2491

Deoxyelephantopin	NF-κB	Cancer
Deoxyelephantopin, a natural bioactive sesquiterpene lactone from Elephantopus scaber, has shown promising anticancer effects against a broad spectrum of cancers. Deoxyelephantopin inhibits *NF-κB, MAPK, PI3K/Akt, and β-catenin* signaling.

HY-N3552

Catalposide	NF-κB	Inflammation/Immunology
Catalposide, an iridoid glycoside that could be isolated from Catalpa ovate G. Don (Bignoniaceae), inhibits TNF-α, IL-1β, and IL-6 productions and NF-κB (p65) activation in lipopolysaccharide-activated RAW 264.7 macrophages.

HY-N6636

Valencene	NF-κB	Inflammation/Immunology
Valencene is a sesquiterpene isolated from Cyperus rotundus, possesses antiallergic, antimelanogenesis, anti-infammatory, and antioxidant activitivies. Valencene inhibits the exaggerated expression of Th2 chemokines and proinflammatory chemokines through blockade of the *NF-κB* pathway. Valencene is used to flavor foods and drinks.

HY-N6857

Armepavine	NF-κB	Inflammation/Immunology
Armepavine, an active compound from Nelumbo nucifera, exerts not only anti-inflammatory effects on human peripheral blood mononuclear cells, but also immunosuppressive effects on T lymphocytes and on lupus nephritic mice. Armepavine inhibits TNF-α-induced MAPK and NF-κB signaling cascades.

HY-142963

TLR4/NF-κB/MAPK-IN-1	NF-κB p38 MAPK Toll-like Receptor (TLR)	Inflammation/Immunology Neurological Disease
TLR4/NF-κB/MAPK-IN-1 is a new type of antineuroinflammatory agent by suppressing TLR4/NF-kB/MAPK pathways.

HY-121955

FW1256	NF-κB Apoptosis	Cancer Inflammation/Immunology Cardiovascular Disease
FW1256 is a phenyl analogue and a slow-releasing hydrogen sulfide (H₂S) donor. FW1256 inhibits *NF-κB* activity and induces cell apoptosis. FW1256 exerts potent anti-inflammatory effects and has the potential for cancer and cardiovascular disease treatment.

HY-N1193

Sulfuretin	NF-κB	Inflammation/Immunology
Sulfuretin inhibits the inflammatory response by suppressing the *NF-κB* pathway. Sulfuretin can be used for the research of allergic airway inflammation. Sulfuretin reduces oxidative stress, platelet aggregation, and mutagenesis. Sulfuretin is a competitive and potent inhibitor of monophenolase and diphenolase activities with the IC₅₀ of 13.64 μM.

HY-117616

Laurotetanine (+)-Laurotetanine	NF-κB	Cancer
Laurotetanine ((+)-Laurotetanine) is an potent and orally active isoquinoline alkaloid and could be extracted from the roots of Litsea cubeba (Lour.) Pers. Laurotetanine exerts an anti-asthmatic effect by inhibition of IgE, histamine, and inflammatory reactions via down-regulating MUC5AC and *NF-κB* signaling pathways.

HY-W018772

D-Ribose(mixture of isomers)	Endogenous Metabolite	Inflammation/Immunology Cancer
D-Ribose(mixture of isomers) is an energy enhancer, and acts as a sugar moiety of ATP, and widely used as a metabolic therapy supplement for chronic fatigue syndrome or cardiac energy metabolism. D-Ribose(mixture of isomers) is active in protein glycation, induces NF-κB inflammation in a RAGE-dependent manner.

HY-N1196

Suberosin	NF-κB	Inflammation/Immunology
Suberosin, isolated from Plumbago zeylanica, exhibits anti-inflammatory and anticoagulant activity. Suberosin suppresses PHA-induced PBMC proliferation and arrested cell cycle progression from the G1 transition to the S phase through the modulation of the transcription factors NF-AT and *NF-κB*.

HY-19759

SRT 2183	Sirtuin Apoptosis	Cancer
SRT 2183 is a selective Sirtuin-1 (SIRT1) activator with an EC_1.5 value of 0.36 μM. SRT 2183 induces growth arrest and apoptosis, concomitant with deacetylation of STAT3 and NF-κB, and reduction of c-Myc protein levels.

HY-N2350

Cynaropicrin	MMP NF-κB TNF Receptor	Cancer
Cynaropicrin is a sesquiterpene lactone which can inhibit tumor necrosis factor (TNF-α) release with IC₅₀s of 8.24 and 3.18 μM for murine and human macrophage cells, respectively. Cynaropicrin also inhibits the increase of cartilage degradation factor (MMP13) and suppresses *NF-κB* signaling.

HY-N1346

Robinin	Toll-like Receptor (TLR)	Inflammation/Immunology
Robinin is present in flavonoid fraction of Vigna unguiculata leaf. Robinin inhibits upregulated expression of TLR2 and TLR4. Robinin ameliorates oxidized low density lipoprotein (Ox-LDL) induced inflammatory insult through TLR4/NF-κB pathway.

HY-139833

Anti-inflammatory agent 6	NF-κB IKK	Inflammation/Immunology
Anti-inflammatory agent 6 blocks the phosphorylation of I kappa b kinase α/β (IKKα/β), IκBα, and *nuclear factor kB p65 (NF-κB* p65)** which is a key controller of inflammation, thereby showing anti-inflammatory potential.

HY-N0279

Cardamonin Cardamomin; Alpinetin chalcone	NF-κB STAT Wnt β-catenin Bcl-2 Family Apoptosis	Cancer Metabolic Disease Inflammation/Immunology Cardiovascular Disease
Cardamonin can be found from cardamom, and target various signaling molecules, transcriptional factors, cytokines and enzymes. Cardamonin can inhibit mTOR, *NF-κB, Akt, STAT3, Wnt/β-catenin* and COX-2. Cardamonin shows anticancer, anti-inflammatory, antimicrobial and antidiabetic activities.

HY-N0722

Neochlorogenic acid trans-5-O-Caffeoylquinic acid	NF-κB Interleukin Related TNF Receptor COX	Inflammation/Immunology Cancer
Neochlorogenic acid is a natural polyphenolic compound found in dried fruits and other plants. Neochlorogenic acid inhibits the production of TNF-α and IL-1β. Neochlorogenic acid suppresses iNOS and COX-2 protein expression. Neochlorogenic acid also inhibits phosphorylated NF-κB p65 and p38 MAPK activation.

HY-126390

(E/Z)-BCI NSC 150117	Phosphatase Apoptosis	Cancer Inflammation/Immunology
(E/Z)-BCI (NSC 150117) is a dual-specificity phosphatase 6 (DUSP6) inhibitor with anti-inflammatory activities. (E/Z)-BCI attenuates LPS-induced inflammatory mediators and ROS production in macrophage cells via activating the Nrf2 signaling axis and inhibiting the NF-κB pathway.

HY-N0569

Madecassic acid	NO Synthase COX TNF Receptor Interleukin Related	Inflammation/Immunology
Madecassic acid is isolated from Centella asiatica (Umbelliferae). Madecassic acid has anti-inflammatory properties caused by iNOS, COX-2, TNF-alpha, IL-1beta, and IL-6 inhibition via the downregulation of *NF-κB* activation in RAW 264.7 macrophage cells.

HY-N1356

Reticuline	JAK STAT NF-κB Endogenous Metabolite	Inflammation/Immunology Cardiovascular Disease
Reticuline shows anti-inflammatory effects through JAK2/STAT3 and *NF-κB* signaling pathways. Reticuline inhibits mRNA expressions of TNF-α, and IL-6 and reduces the phosphorylation levels of JAK2 and STAT3. Reticuline exhibits cardiovascular effects.

HY-147712

PKC-IN-4	PKC	Inflammation/Immunology
PKC-IN-4 (compound 7l) is a potent and orally active aPKC inhibitor with an IC₅₀ of 0.52 µM. PKC-IN-4 inhibits TNF-α induced NF-κB activity in vitro. PKC-IN-4 blocks VEGF- and TNFα-induced permeability across the retinal vasculature.

HY-125171

IAXO-102	Toll-like Receptor (TLR)	Inflammation/Immunology
IAXO-102 is a TLR4 antagonist which negatively regulates TLR4 signalling. IAXO-102 inhibits MAPK and p65 NF-κB phosphorylation and expression of TLR4 dependent proinflammatory protein. IAXO-102 also prevents experimental abdominal aortic aneurysm development.

HY-N2098

Obtusifolin	NF-κB	Cancer
Obtusifolin, isolated from the seeds of Cassia obtusifolia, regulates the gene expression and production of MUC5AC mucin in airway epithelial cells via inhibiting *NF-kB* pathway. Obtusifolin suppresses phthalate esters-induced breast cancer bone metastasis by targeting parathyroid hormone-related protein.

HY-P1098

Ac2-26	NF-κB	Inflammation/Immunology
Ac2-26, an active N-terminal peptide of annexin A1 (AnxA1), attenuates ischemia-reperfusion-induced acute lung injury. Ac2-26 also decreases AnxA1 protein expression, inhibits the activation of NF-κB and MAPK pathways in the injured lung tissue.

HY-15027S1

5-Aminosalicylic acid-d3 Mesalamine-d₃; 5-ASA-d₃; Mesalazine-d₃	PPAR PAK NF-κB Endogenous Metabolite	Inflammation/Immunology Cancer
5-Aminosalicylic acid-d₃ is the deuterium labeled 5-Aminosalicylic Acid. 5-Aminosalicylic acid (Mesalamine) acts as a specific PPARγ agonist and also inhibits p21-activated kinase 1 (PAK1) and NF-κB[1][2][3][4].

HY-116626

SM-7368	NF-κB p38 MAPK MMP	Cancer
SM-7368 is a potent *NF-kB* inhibitor that targets downstream of MAPK p38 activation. SM-7368 inhibits TNF-α-induced MMP-9 upregulation. SM-7368 can be used for the research of chemotherapies targeting TNF-α-mediated tumor invasion and metastasis .

HY-101402

Cyclo(his-pro) Cyclo(histidyl-proline); Histidylproline diketopiperazine	NF-κB Endogenous Metabolite	Inflammation/Immunology Neurological Disease
Cyclo(his-pro) (Cyclo(histidyl-proline)) is an orally active cyclic dipeptide structurally related to tyreotropin-releasing hormone. Cyclo(his-pro) could inhibit *NF-κB* nuclear accumulation. Cyclo(his-pro) can cross the brain-blood-barrier and affect diverse inflammatory and stress responses.

HY-N11657

Sanggenon A Sanggenone A	NF-κB Keap1-Nrf2	Inflammation/Immunology
Sanggenon A (Sanggenone A) exerts anti-inflammatory effects by regulating NF-κB and HO-1/Nrf2 signaling pathways in BV2 and RAW264.7 cells. Sanggenon A markedly inhibits the Lipopolysaccharide (LPS; HY-D1056)-induced production of nitric oxide.

HY-10227

Bortezomib PS-341; LDP-341; NSC 681239	Proteasome NF-κB Apoptosis Autophagy	Cancer
Bortezomib (PS-341) is a reversible and selective proteasome inhibitor, and potently inhibits 20S proteasome (K_i=0.6 nM) by targeting a threonine residue. Bortezomib disrupts the cell cycle, induces apoptosis, and inhibits *NF-κB*. Bortezomib is the first proteasome inhibitor anticancer agent. Anti-cancer activity.

HY-N2450

Sulforaphene	Apoptosis EGFR ERK NF-κB	Cancer
Sulforaphene, isolated from radish seeds, exhibits an ED₅₀ against velvetleaf seedlings approximately 2 x 10^-4 M. Sulforaphene promotes cancer cells apoptosis and inhibits migration via inhibiting EGFR, p-ERK1/2, *NF‐κB* and other signals.

HY-N0633

Muscone	Interleukin Related TNF Receptor NF-κB NOD-like Receptor (NLR)	Inflammation/Immunology Cardiovascular Disease
Muscone is the main active monomer of traditional Chinese medicine musk. Muscone inhibits *NF-κB* and NLRP3 inflammasome activation. Muscone remarkably decreases the levels of inflammatory cytokines (IL-1β, TNF-α and IL-6), and ultimately improves cardiac function and survival rate.

HY-117066

CL075 3M002	Toll-like Receptor (TLR)	Inflammation/Immunology
CL075 (3M002) is a selective TLR8 agonist with immunomodulating properties. CL075 triggers a MyD88-dependent signaling pathway to elicit production of inflammatory cytokines and type I interferons (IFNs) via activation of NF-κB and IRF7, respectively.

HY-N6966

Ethyl Caffeate	NF-κB NO Synthase COX PGE synthase	Inflammation/Immunology Cancer
Ethyl Caffeate is a natural phenolic compound isolated from Bidens pilosa. Ethyl caffeate suppresses *NF-κB* activation and its downstream inflammatory mediators, inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), and prostaglandin E₂ (PGE₂) in vitro or in mouse skin.

HY-136477

Pentagamavunon-1 PGV-1	Apoptosis COX VEGFR NF-κB	Cancer
Pentagamavunon-1 (PGV-1), a Curcumin analog with oral activity, targets on several molecular mechanisms to induce apoptosis including inhibition of angiogenic factors cyclooxygenase-2 (COX-2) and vascular endothelial growth factor (VEGF). PGV-1 inhibits *NF-κB* activation.

HY-N0005S

Curcumin-d6 Diferuloylmethane-d₆; Natural Yellow 3-d₆; Turmeric yellow-d₆	Keap1-Nrf2 Ferroptosis Autophagy Histone Acetyltransferase Epigenetic Reader Domain Mitophagy Influenza Virus	Infection Metabolic Disease Inflammation/Immunology
Curcumin-d₆is a deuterium labeled Curcumin (Turmeric yellow). Curcumin (Turmeric yellow) is a natural phenolic compound with diverse pharmacologic effects including anti-inflammatory, antioxidant, antiproliferative and antiangiogenic activities. Curcumin is an inhibitor of p300 histone acetylatransferase (HATs) and also shows inhibitory effects on NF-κB and MAPKs.

HY-139714

IMD-vanillin
NF-κB Cancer

IMD-vanillin is a novel imidazoquinolinone-NF-κB immunomodulator dimers.

HY-B0084

Dienogest STS 557	Progesterone Receptor	Endocrinology
Dienogest (STS-557) is an orally active and selective progesterone receptor agonist that effectively reduces the gene expression of COX-2, mPGES-1 and aromatase. Dienogest also inhibits the mRNA and protein expression of PGE₂ synthase and the activation of *NF-κB*. Dienogest can be used in studies of endometriosis, menopause and menorrhagia.

HY-N2106

Dehydroevodiamine	NF-κB COX PGE synthase NO Synthase	Inflammation/Immunology
Dehydroevodiamine is a major bioactive quinazoline alkaloid isolated from Evodiae Fructus, has an antiarrhythmic effect in guinea-pig ventricular myocytes. Dehydroevodiamine inhibits LPS-induced iNOS, COX-2, prostaglandin E2 (PGE2) and nuclear factor-kappa B (NF-κB) expression in murine macrophage cells.

HY-15027S2

5-Aminosalicylic acid-13C6 Mesalamine-¹³C₆; 5-ASA-¹³C₆; Mesalazine-¹³C₆	PPAR PAK NF-κB Endogenous Metabolite
5-Aminosalicylic acid-¹³C₆ is the ¹³C labeled 5-Aminosalicylic Acid[1]. 5-Aminosalicylic acid (Mesalamine) acts as a specific PPARγ agonist and also inhibits p21-activated kinase 1 (PAK1) and NF-κB[2][3][4].

HY-100538A

DTP3 TFA	DNA/RNA Synthesis JNK	Cancer
DTP3 TFA is a potent and selective GADD45β/MKK7 (growth arrest and DNA-damage-inducible β/mitogen-activated protein kinase kinase 7) inhibitor. DTP3 TFA targets an essential, cancer-selective cell-survival module downstream of the NF-κB pathway.

HY-P1098A

Ac2-26 TFA	NF-κB	Inflammation/Immunology
Ac2-26 TFA, an active N-terminal peptide of annexin A1 (AnxA1), attenuates ischemia-reperfusion-induced acute lung injury. Ac2-26 also decreases AnxA1 protein expression, inhibits the activation of NF-κB and MAPK pathways in the injured lung tissue.

HY-N0041

Ginsenoside Rb3 Gypenoside IV	NF-κB COX NO Synthase	Cancer Inflammation/Immunology
Ginsenoside Rb3 is extracted from steamed Panax ginseng C. A. Meyer. Ginsenoside Rb3 exhibits inhibitory effect on TNFα-induced *NF-κB* transcriptional activity with an IC₅₀ of 8.2 μM in 293T cell lines. Ginsenoside Rb3 also inhibits the induction of COX-2 and iNOS mRNA.

HY-N3480

Isogosferol (+)-Isogospherol; Isogospherol	Others	Inflammation/Immunology
Isogosferol ((+)-Isogospherol; Isogospherol) is a potent anti-inflammatory agent. Isogosferol decreases LPS (HY-D1056)-stimulated NO and IL-1β expression. Isogosferol decreases the LPS (HY-D1056)-stimulated expression of iNOS, COX-2, NF-κB, and pERK1/2.

HY-126307

Urolithin B	NF-κB JNK ERK Akt AMPK Endogenous Metabolite	Inflammation/Immunology
Urolithin B is one of the gut microbial metabolites of ellagitannins, and has anti-inflammatory and antioxidant effects. Urolithin B inhibits *NF-κB* activity by reducing the phosphorylation and degradation of IκBα, and suppresses the phosphorylation of JNK, ERK, and Akt, and enhances the phosphorylation of AMPK. Urolithin B is also a regulator of skeletal muscle mass.

HY-18739

Phorbol 12-myristate 13-acetate PMA; TPA; Phorbol myristate acetate	PKC SphK NF-κB	Inflammation/Immunology
Phorbol 12-myristate 13-acetate (PMA), a phorbol ester, is a dual SphK and protein kinase C (PKC) activator. Phorbol 12-myristate 13-acetate is a NF-κB activator. Phorbol 12-myristate 13-acetate induces differentiation in THP-1 cells.

HY-149087

MR2938	Cholinesterase (ChE) NF-κB Interleukin Related TNF Receptor CCR NOD-like Receptor (NLR) JNK NO Synthase	Inflammation/Immunology Neurological Disease
MR2938 is a potent AChE inhibitor, with an IC₅₀ of 5.04 μM. MR2938 also suppresses NO production obviously (IC₅₀ = 3.29 μM). MR2938 suppresses the neuroinflammation through blocking MAPK/JNK and *NF-κB* signaling pathways. MR2938 can be used for Alzheimer’s disease (AD) research.

HY-N10638

N-Acetyldopamine dimer-2	Reactive Oxygen Species NF-κB	Inflammation/Immunology
N-Acetyldopamine dimer-2 (compound 2) is a N-acetyldopamine dimer that can be isolated from the yellow powder form Periostracum Cicadae with antioxidant and anti-inflammatory activities. N-Acetyldopamine dimer-2 inhibits oxidized low-density lipoprotein (LDL) oxidation, ROS generation, NO production, and NF-κB activity.

HY-N8211

Gypenoside L	p38 MAPK ERK NF-κB	Cancer Inflammation/Immunology
Gypenoside L is a saponin that can be found in Gynostemma pentaphyllum. Gypenoside L increases the SA-β-galactosidase activity, promotes the production of senescence-associated secretory cytokines. Gypenoside L also can activate p38 and ERK MAPK pathways and NF-κB pathway to induce senescence. Gypenoside L exhibits anti-tumor and anti-inflammatory activities.

HY-N0510

Aristolochic acid A Aristolochic acid I; TR 1736	NF-κB	Cancer
Aristolochic acid A (Aristolochic acid I; TR 1736) is the main component of plant extract Aristolochic acids, which are found in various herbal plants of genus Aristolochia and Asarum. Aristolochic acid A significantly reduces both activator protein 1 (AP-1) and *NF-κB* activities. Aristolochic acid A reduces BLCAP gene expression in human cell lines.

HY-B0185B

Lidocaine hydrochloride hydrate Lignocaine hydrochloride hydrate	Sodium Channel MEK ERK NF-κB Apoptosis	Cancer Cardiovascular Disease
Lidocaine (Lignocaine) hydrochloride hydrate inhibits sodium channels involving complex voltage and using dependence. Lidocaine hydrochloride hydrate decreases growth, migration and invasion of gastric carcinoma cells via up-regulating miR-145 expression and further inactivation of MEK/ERK and *NF-κB* signaling pathways. Lidocaine hydrochloride hydrate is an amide derivative and has potential for the research of ventricular arrhythmia.

HY-101364A

CHPG sodium salt	mGluR NF-κB ERK Akt	Inflammation/Immunology Neurological Disease
CHPG sodium salt is a selective mGluR5 agonist, and attenuates SO₂-induced oxidative stress and inflammation through *TSG-6/NF-κB* pathway in BV2 microglial cells. CHPG sodium salt protects against traumatic brain injury (TBI) in vitro and in vivo by activation of the ERK and Akt signaling pathways..

HY-120934

C25-140	TNF Receptor E1/E2/E3 Enzyme	Inflammation/Immunology
C25-140, a first-in-class, orally active, and fairly selective TRAF6-Ubc13 inhibitor, directly binds to TRAF6, and blocks the interaction of TRAF6 with Ubc13. C25-140 lowers TRAF6 activity, reduces *NF-κB* activation, and combats autoimmunity.

HY-N0001S

(±)-Epicatechin-13C3	Ferroptosis Endogenous Metabolite COX	Cancer Inflammation/Immunology
(±)-Epicatechin-¹³C₃ is the ¹³C labeled (±)-Epicatechin. (-)-Epicatechin (HY-N0001) inhibits cyclooxygenase-1 (COX-1) with an IC50 of 3.2 μM. (-)-Epicatechin inhibits the IL-1β-induced expression of iNOS by blocking the nuclear localization of the p65 subunit of NF-κB[1].

HY-137315S

TML-6-d3	NF-κB mTOR Keap1-Nrf2 Amyloid-β	Neurological Disease
TML-6-d₃ is the deuterium labeled TML-6. TML-6, an orally active curcumin derivative, inhibits the synthesis of the β-amyloid precursor protein and β-amyloid (Aβ). TML-6 can upregulate Apo E, suppress NF-κB and mTOR, and increase the activity of the anti-

HY-B0185

Lidocaine Lignocaine	Sodium Channel MEK ERK NF-κB Apoptosis	Cancer Cardiovascular Disease
Lidocaine (Lignocaine) inhibits sodium channels involving complex voltage and using dependence. Lidocaine decreases growth, migration and invasion of gastric carcinoma cells via up-regulating miR-145 expression and further inactivation of MEK/ERK and *NF-κB* signaling pathways. Lidocaine is an amide derivative and has potential for the research of ventricular arrhythmia.

HY-101402A

Cyclo(his-pro) TFA Cyclo(histidyl-proline) TFA; Histidylproline diketopiperazine TFA	NF-κB Endogenous Metabolite	Inflammation/Immunology Neurological Disease
Cyclo(his-pro) TFA (Cyclo(histidyl-proline) TFA) is an orally active cyclic dipeptide structurally related to tyreotropin-releasing hormone. Cyclo(his-pro) TFA could inhibit *NF-κB* nuclear accumulation. Cyclo(his-pro) TFA can cross the brain-blood-barrier and affect diverse inflammatory and stress responses.

HY-N3071

Picrasidine I	Apoptosis Reactive Oxygen Species	Inflammation/Immunology
Picrasidine I is an anti-inflammatory and anti-osteoclastogenic dimeric alkaloid that can be isolated from Picrasma quassioides. Picrasidine I inducs cell cycle arrest, and triggers cell apoptosis by downregulats ERK and Akt pathways. Picrasidine I inhibits the activation of MAPKs, *NF-κB* and ROS generation, and suppresses the expression of c-Fos and NFATc1.

HY-N0831

Jaceosidin	Bcl-2 Family COX Apoptosis	Cancer Inflammation/Immunology
Jaceosidin is a flavonoid isolated from Artemisia vestita, induces apoptosis in cancer cells, activates Bax and down-regulates Mcl-1 and c-FLIP expression. Jaceosidin exhibits anti-cancer, anti-inflammatory activities, decreases leves of inflammatory markers, and suppresses COX-2 expression and NF-κB activation.

HY-101364

CHPG	mGluR NF-κB ERK Akt	Inflammation/Immunology Cardiovascular Disease
CHPG is a selective mGluR5 agonist, and attenuates SO₂-induced oxidative stress and inflammation through *TSG-6/NF-κB* pathway in BV2 microglial cells. CHPG protects against traumatic brain injury (TBI) in vitro and in vivo by activation of the ERK and Akt signaling pathways.

HY-108694

γ-Tocotrienol	Endogenous Metabolite NF-κB	Metabolic Disease Inflammation/Immunology
γ-Tocotrienol is an active form of vitamin E. γ-tocotrienol reverses the multidrug resistance (MDR) of breast cancer cells through the signaling pathway of NF-κB and P-gp. γ-Tocotrienol is also a novel radioprotector agent, can mitigate bone marrow radiation damage during targeted radionuclide treatment.

HY-N0104

Curcumol (-)-Curcumol	Apoptosis	Cancer
Curcumol ((-)-Curcumol), a bioactive sesquiterpenoid, possesses numerous pharmacological activities like anticancer, antimicrobial, antifungal, antiviral, and antiinflammatory. Curcumol is a potent inducer of apoptosis in numerous cancer cells via targeting key signaling pathways as MAPK/ERK, PI3K/Akt and NF-κB which are generally deregulated in several cancers.

HY-B0185A

Lidocaine hydrochloride Lignocaine hydrochloride	Sodium Channel MEK ERK NF-κB Apoptosis	Cancer Cardiovascular Disease
Lidocaine hydrochloride (Lignocaine hydrochloride) inhibits sodium channels involving complex voltage and using dependence. Lidocaine hydrochloride decreases growth, migration and invasion of gastric carcinoma cells via up-regulating miR-145 expression and further inactivation of MEK/ERK and *NF-κB* signaling pathways. Lidocaine hydrochloride is an amide derivative and a agent to treat ventricular arrhythmia and an effective tumor-inhibitor.

HY-N6607

Tryptanthrin	Leukotriene Receptor NO Synthase NF-κB COX TNF Receptor Interleukin Related	Cancer Inflammation/Immunology
Tryptanthrin is an indole quinazoline that could be an alkaloid from indigo-bearing plants. Tryptanthrin is a potent and orally active cellular Leukotriene (LT) biosynthesis inhibitor. Tryptanthrin has anticancer activity. Tryptanthrin suppresses the expression levels of NOS1, COX-2, and NF-κB and regulates the expression levels of IL-2, IL-10, and TNF-α.

HY-B0808S1

Oxaprozin-d5 Oxaprozinum-d₅; Wy21743-d₅	COX NF-κB	Inflammation/Immunology Cancer
Oxaprozin-d₅ is deuterium labeled Oxaprozin. Oxaprozin is an inhibitor of both COX-1 and COX-2 with IC50s of 2.2 μM and 36 μM for human platelet COX-1 and IL-1-stimulated human synovial cell COX-2, respectively. Oxaprozin also inhibits the activation of NF-κB.

HY-N7056

4'-Hydroxychalcone	Proteasome	Cancer Inflammation/Immunology
4'-Hydroxychalcone is a chalcone isolated from licorice root, with hepatoprotective activity. 4'-Hydroxychalcone inhibits TNFα-induced NF-κB activation via proteasome inhibition. 4'-Hydroxychalcone induces a rapid potassium release from mitochondrial vesicles and causes deterioration of respiratory control and oxidative phosphorylation of isolated rat liver mitochondria.

HY-N6009

8-Deoxygartanin	Parasite NF-κB	Infection
8-Deoxygartanin, a prenylated xanthones from G. mangostana, is a selective inhibitor of butyrylcholinesterase (BChE). 8-Deoxygartanin exhibits antiplasmodial activity with an IC₅₀ of 11.8 μM for the W2 strain of Plasmodium falciparum. 8-Deoxygartanin inhibits NF-κB (p65) activation with an IC₅₀ of 11.3 μM.

HY-118160

PPM-18 NSC 73233	NO Synthase	Inflammation/Immunology Cancer
PPM-18 (NSC 73233), a potent anti-inflammatory agent, inhibits nitric oxide synthase expression. PPM-18 is a potent inhibitor of iNOS expression by blocking the binding of NF-κB to promoter. PPM-18, an analog of Vitamin K, induces autophagy and apoptosis in bladder cancer cells through ROS and AMPK signaling pathways.

HY-117987

CPS-11 N-(Hydroxymethyl)thalidomide	Nuclear Factor of activated T Cells (NFAT) NF-κB Reactive Oxygen Species	Cancer
CPS-11 (N-(Hydroxymethyl)thalidomide) a Thalidomide (HY-14658) analogue, is a potent anti-cancer agent. CPS-11 inhibits *NF-κB, activates NFAT, and repress cytokine expression through elevated ROS*. CPS-11 exhibits a wider activity spectrum and higher potency against MM (multiple myeloma) cell lines.

HY-N6246

Asperulosidic Acid	NF-κB ERK	Cancer Inflammation/Immunology
Asperulosidic Acid (ASPA), a bioactive iridoid glycoside, is extracted from the herbs of Hedyotis diffusa Willd. Asperulosidic Acid (ASPA) has anti-tumor, anti-oxidant, and anti-inflammatory activities. ASPA is related to the inhibition of inflammatory cytokines (TNF-α, IL-6) and mediators via suppression of the *NF-κB* and mitogen-activated protein kinase (MAPK) signaling pathways.

HY-146419

Anti-inflammatory agent 20	NF-κB COX TNF Receptor	Inflammation/Immunology
Anti-inflammatory agent 20 (compound 5a) is a potent inhibitor of NO activity. Anti-inflammatory agent 20 shows anti-inflammatory activity. Anti-inflammatory agent 20 suppresses LPS-induced inflammation via inhibiting the activation of *NF-κB* and MAPK signaling and thereby reducing IL-6, TNF-α, iNOS, and COX-2 upregulation.

HY-N0634

Cimifugin Cimitin	NF-κB	Inflammation/Immunology
Cimifugin (Cimitin) is a bioactive component of Cimicifuga racemosa, a Chinese herb. Cimifugin suppresses allergic inflammation by reducing epithelial derived initiative key factors via regulating tight junctions. Cimifugin reduces the migration and chemotaxis of RAW264.7 cells and inhibits the release of inflammatory factors and activation of MAPKs and NF-κB signaling pathways induced by LPS.

HY-14654

Aspirin Acetylsalicylic Acid; ASA	COX Virus Protease NF-κB Autophagy Apoptosis Mitophagy Caspase p38 MAPK	Cancer Infection Metabolic Disease Inflammation/Immunology Cardiovascular Disease
Aspirin (Acetylsalicylic Acid) is an orally active, potent and irreversible inhibitor of cyclooxygenase COX-1 and COX-2, with IC₅₀ values of 5 and 210 μg/mL, respectively. Aspirin induces apoptosis. Aspirin inhibits the activation of *NF-κB. Aspirin also inhibits platelet prostaglandin synthetase*, and can prevent coronary artery and cerebrovascular thrombosis.

HY-14621

Zingerone Vanillylacetone; Gingerone	NF-κB	Cancer Metabolic Disease Inflammation/Immunology
Zingerone (Vanillylacetone) is a nontoxic methoxyphenol isolated from Zingiber officinale, with potent anti-inflammatory, antidiabetic, antilipolytic, antidiarrhoeic, antispasmodic and anti-tumor properties. Zingerone alleviates oxidative stress and inflammation, down-regulates NF-κB mediated signaling pathways. Zingerone acts as an anti-mitotic agent, and inhibits the growth of neuroblastoma cells.

HY-N1930

(-)-Hinesol Hinesol	Apoptosis	Cancer
(-)-Hinesol (Hinesol) is a potent anticancer agent. (-)-Hinesol induces apoptosis and cell cycle arrest at G0/G1 phase. (-)-Hinesol downregulates MEK/ERK pathway and NF-κB pathway and mediates theexpression of cyclin D1, Bax and Bcl-2. (-)-Hinesol has the potential for the research of non–small cell lung cancer.

HY-147561

ALPK1-IN-1	NF-κB	Inflammation/Immunology Infection
ALPK1-IN-1 (Compound A001) is a potent inhibitor of alpha-kinase 1 (ALPK1). ALPK1 is an intracytoplasmic serine threonine protein kinase that plays an important role in activating the innate immune response to bacteria via TRAF-interacting protein with forkhead-associated domain (TIFA) dependent proinflammatory NF-κB signaling.

HY-137315

TML-6	Amyloid-β NF-κB mTOR Keap1-Nrf2	Neurological Disease
TML-6, an orally active curcumin derivative, inhibits the synthesis of the β-amyloid precursor protein and β-amyloid (Aβ). TML-6 can upregulate Apo E, suppress *NF-κB* and mTOR, and increase the activity of the anti-oxidative Nrf2 gene. TML-6 has the potential for Alzheimer’s disease (AD) research.

HY-N8884

Coelonin	PTEN Akt NF-κB Interleukin Related TNF Receptor	Inflammation/Immunology
Coelonin is a dihydrophenanthrene with anti-inflammation activity. Coelonin inhibits LPS-induced PTEN phosphorylation. Coelonin inhibits *NF-κB* activation and p27Kip1 degradation by regulating the PI3K/AKT pathway negatively. Coelonin can inhibit IκBα phosphorylation and degradation and increases the expression of IκBα protein.

HY-14299

Indacaterol	Adrenergic Receptor	Inflammation/Immunology Cardiovascular Disease
Indacaterol is an orally active ultra-long-acting β2 adrenergic receptor (ADRB2) agonist. Indacaterol inhibits *NF-κB* activity in a β-arrestin2-dependent manner, preventing further lung damage and improving lung function in COPD (chronic obstructive pulmonary disorder). Indacaterol can also be used in cardiovascular disease research.

HY-N10047

7,8-Didehydrocimigenol	NF-κB PPAR	Cardiovascular Disease
7,8-Didehydrocimigenol is an active triterpenoid that can be isolated from Cimicifugae rhizoma. 7,8-Didehydrocimigenol inhibits TNF-α-induced VCAM-1 expression, inhibits *NF-kB* activity and phosphorylation of ERK1/2 and Akt, increases PPAR-γ expression. 7,8-Didehydrocimigenol can be used for the research of cardiovascular disorders such as atherosclerosis.

HY-107818

4-Hydroxychalcone	NF-κB	Inflammation/Immunology Cardiovascular Disease
4-Hydroxychalcone is a chalcone metabolite with anti-angiogenic and anti-inflammatory activities. 4-Hydroxychalcone suppresses angiogenesis by suppression of growth factor pathway with no signs of cytotoxicity. 4-Hydroxychalcone inhibits TNF-α induced *NF-κB* pathway activation and activates BMP signaling, reduces resistant hypertension (RH) by attenuating hyperaldosteronism and renal injury in mice.

HY-10227S

Bortezomib-d8 PS-341-d₈; LDP-341-d₈; NSC 681239-d₈	Proteasome NF-κB Apoptosis Autophagy	Cancer
Bortezomib-d₈ is the deuterium labeled Bortezomib. Bortezomib (PS-341) is a reversible and selective proteasome inhibitor, and potently inhibits 20S proteasome (Ki=0.6 nM) by targeting a threonine residue. Bortezomib disrupts the cell cycle, induces apoptosis, and inhibits NF-κB. Bortezomib is the first proteasome inhibitor anticancer agent. Anti-cancer activity[1][2].

HY-N0665

Specnuezhenide (8E)-Nuezhenide	NF-κB Wnt	Inflammation/Immunology
Specnuezhenide ((8E)-Nuezhenide) is isolated from the fruits of Ligustrum lucidum. Specnuezhenide ((8E)-Nuezhenide) can inhibit IL-1β-induced inflammation in chondrocytes via inhibition of *NF-κB* and wnt/β-catenin signaling. Specnuezhenide ((8E)-Nuezhenide) exerts anti-inflammatory effects in a rat model of osteoarthritis (OA).

HY-Y1832

o-Vanillin 2-Vanillin	Fungal	Cancer Infection
o-Vanillin (2-Vanillin) is a nature product, could be extracted from Vanilla planifolia, Pinus koraiensis fruit. o-Vanillin is a potent antifungal agent. o-Vanillin inhibits the growth of mycelia by disrupting the integrity of cell walls and cell membranes. o-Vanillin inhibits Doxorubicin (HY-15142A)- and 4-hydroperoxycyclophosphamide-induced NF-κB activation.

HY-123984

LTβR-IN-1	NF-κB	Metabolic Disease
LTβR-IN-1 is a potent, selective lymphotoxin β receptor (LTβR) inhibitor. LTβR-IN-1 also selectively inhibits the nuclear translocation of p52 depended on TNF12A, instead of the nuclear translocation of p65 mediated by TNF-α receptor. LTβR-IN-1 regulates the NF-kB signaling pathway IN a ligand-independent manner.

HY-150744

ODN 24888	Toll-like Receptor (TLR)	Inflammation/Immunology
ODN 24888 is an guanine-modified inhibitory oligonucleotides (INH-ODN), shows potent inhibition on TLR7/TLR9-mediated signaling. ODN 24888 impairs IFN-α level and NF-κB activation, inhibits IL-6 release. ODN 24888 involves in immune and inflammatory responses, can be used as a vaccine adjuvant.

HY-P1439A

RS 09 TFA	Toll-like Receptor (TLR)	Inflammation/Immunology
RS 09 TFA is a TLR4 agonist. RS 09 TFA promotes NF-κB nuclear translocation and induces inflammatory cytokine secretion in RAW264.7 macrophages in vitro. RS 09 TFA acts as an adjuvant in vivo; RS 09 TFA enhances X-15 specific antibody serum concentrations, when administered with X-15-KLH in mice.

HY-126047B

(R)-(+)-Anatabine	NF-κB Amyloid-β nAChR	Inflammation/Immunology Neurological Disease
(R)-(+)-Anatabine is an less active R-enantiomer of Anatabine. Anatabine is a potent α4β2 nAChR agonist. Anatabine inhibits *NF-κB* activation lower amyloid-β (Aβ) production by preventing the β-cleavage of amyloid precursor protein (APP). Anatabine has anti-inflammatory effects and has the potential for neurodegenerative disorders treatment.

HY-135396

(1S,2S)-Bortezomib	Proteasome Apoptosis	Cancer
(1S,2S)-Bortezomib is an enantiomer of Bortezomib. Bortezomib is a cell-permeable, reversible, and selective proteasome inhibitor, and potently inhibits 20S proteasome (K_i of 0.6 nM) by targeting a threonine residue. Bortezomib disrupts the cell cycle, induces apoptosis, and inhibits *NF-κB*. Bortezomib is an anti-cancer agent and the first therapeutic proteasome inhibitor to be used in humans.

HY-100594

EUK-134	NF-κB	Cardiovascular Disease
EUK-134, a synthetic superoxide dismutase and catalase mimetic, protects rat kidneys from ischemia-reperfusion-induced damage. EUK-134 is a superoxide dismutase (SOD) mimetics (SODm) with catalase activity. EUK-134 is a mitoprotective antioxidant. EUK-134 reduces the expression of *NF-κB*, MDA level, and protein carbonylation in H9C2 cells.

HY-14654A

Aspirin lithium Acetylsalicylic Acid lithium; ASA lithium	COX Virus Protease NF-κB Autophagy Apoptosis Mitophagy Caspase p38 MAPK	Cancer Infection Metabolic Disease Inflammation/Immunology Cardiovascular Disease
Aspirin (Acetylsalicylic Acid) lithium is an orally active, potent and irreversible inhibitor of cyclooxygenase COX-1 and COX-2, with IC₅₀ values of 5 and 210 μg/mL, respectively. Aspirin lithium induces apoptosis. Aspirin lithium inhibits the activation of *NF-κB. Aspirin lithium also inhibits platelet prostaglandin synthetase*, and can prevent coronary artery and cerebrovascular thrombosis.

HY-B0185AS

Lidocaine-d10 hydrochloride	Sodium Channel MEK ERK NF-κB Apoptosis	Cancer Cardiovascular Disease
Lidocaine-d₁₀ (hydrochloride) is the deuterium labeled Lidocaine hydrochloride. Lidocaine hydrochloride (Lignocaine hydrochloride) inhibits sodium channels involving complex voltage and using dependence[1]. Lidocaine hydrochloride decreases growth, migration and invasion of gastric carcinoma cells via up-regulating miR-145 expression and further inactivation of MEK/ERK and NF-κB signaling pathways. Lidocaine hydrochloride, an amide derivative, has the potential for the research of the ventricular arrhythmia[2].

HY-14299A

Indacaterol maleate QAB149	Adrenergic Receptor	Endocrinology
Indacaterol maleate (QAB149) is an orally active ultra-long-acting β2 adrenergic receptor (ADRB2) agonist. Indacaterol maleate inhibits *NF-κB* activity in a β-arrestin2-dependent manner, preventing further lung damage and improving lung function in COPD (chronic obstructive pulmonary disorder). Indacaterol maleate can also be used in cardiovascular disease research.

HY-110261

GS143	IKK E1/E2/E3 Enzyme NF-κB	Inflammation/Immunology
GS143 is a selective IκBα ubiquitination inhibitor with an IC₅₀ of 5.2 μM for SCF^βTrCP1-mediated IκBα ubiquitylation. GS143 suppresses *NF-κB* activation and transcription of target genes and does not inhibit proteasome activity. GS143 has anti-asthma effect.

HY-151876

Glucocorticoid receptor modulator 1	Glucocorticoid Receptor NF-κB AP-1	Inflammation/Immunology
Glucocorticoid receptor modulator 1 is a highly potent and orally active non-steroidal selective glucocorticoid receptor modulator with an IC₅₀ value of 9 nM and 130 nM for *NF-κB* and AP-1, respectively. Glucocorticoid receptor modulator 1 can effectively reduce the expression of inflammatory factors IL-6, IL-1β, TNF-α, also can relieve dermatitis in mice.

HY-B0185S1

Lidocaine-d10	Sodium Channel MEK ERK NF-κB Apoptosis	Cancer Cardiovascular Disease
Lidocaine-d₁₀ is the deuterium labeled Lidocaine. Lidocaine (Lignocaine) inhibits sodium channels involving complex voltage and using dependence[1]. Lidocaine decreases growth, migration and invasion of gastric carcinoma cells via up-regulating miR-145 expression and further inactivation of MEK/ERK and NF-κB signaling pathways. Lidocaine is an amide derivative and has potential for the research of ventricular arrhythmia[2].

HY-N2259

Curcumenol (+)-Curcumenol	Cytochrome P450	Cancer Inflammation/Immunology Neurological Disease
Curcumenol ((+)-Curcumenol) is a potent CYP3A4 inhibitor with an IC₅₀ of 12.6 μM, which is one of constituents in the plants of medicinally important genus of Curcuma zedoaria, with neuroprotection, anti-inflammatory, anti-tumor and hepatoprotective activities. Curcumenol ((+)-Curcumenol) suppresses Akt-mediated NF-κB activation and p38 MAPK signaling pathway in LPS-stimulated BV-2 microglial cells.

HY-150587

Anti-inflammatory agent 31	ERK NF-κB	Inflammation/Immunology
Anti-inflammatory agent 31 (enone 17) is a kind of andrographolide derivatives, is a anti-inflammatory agent. Anti-inflammatory agent 31 inhibits *NF-κB* activation by upstream blockade of PI3K/Akt and ERK1/2 MAPK activation. Anti-inflammatory agent 31 shows recovery effective of the intracellular GSH levels and protective effect on liver.

HY-100487

TAK-243 MLN7243	E1/E2/E3 Enzyme NF-κB Apoptosis	Cancer
TAK-243 (MLN7243) is a first-in-class, selective ubiquitin activating enzyme, UAE (UBA1) inhibitor (IC₅₀=1 nM), which blocks ubiquitin conjugation, disrupting monoubiquitin signaling as well as global protein ubiquitination. TAK-243 (MLN7243) induces endoplasmic reticulum (ER) stress, abrogates *NF-κB* pathway activation and promotes apoptosis.

HY-N6966A

Ethyl trans-caffeate	Others	Inflammation/Immunology
Ethyl trans-caffeate is the trans form of Ethyl Caffeate (HY-N6966). Ethyl Caffeate is a natural phenolic compound isolated from Bidens pilosa. Ethyl caffeate suppresses *NF-κB* activation and its downstream inflammatory mediators, inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), and prostaglandin E₂ (PGE₂) in vitro or in mouse skin.

HY-N0460

1-Caffeoylquinic acid	NF-κB	Cancer
1-Caffeoylquinic acid is an effective *NF-κB* inhibitor, shows significant binding affinity to the RH domain of p105 with K_i of 0.002 μM and binding energy of 1.50 Kcal/mol. 1-Caffeoylquinic acid has anti-oxidative stress ability. 1-Caffeoylquinic acid inhibits PD-1/PD-L1 interact.

HY-134000

Emodic acid NSC624610	p38 MAPK NF-κB ERK JNK VEGFR MMP	Cancer
Emodic acid (NSC624610) is an anthraquinone compound isolated from A. microcarpus, which can inhibit the proliferation of cancer cells by inhibiting the activity of *NF-κB. Emodic acid can also inhibit the phosphorylation of p38, ERK* and JNK, the secretion of tumor-promoting cytokines IL-1β and IL-6, and the expression of VEGF and MMP, thereby inhibiting the invasion and migration potential of cancer cells.

HY-139717

IMD-biphenylA
NF-κB Cancer

IMD-biphenylA is a novel imidazoquinolinone-NF-κB immunomodulator dimer that improves the adjuvanticity of small molecule immune potentiators.

HY-124056

AZ10397767	CXCR	Cancer
AZ10397767 is an orally active, selective CXCR2 receptor antagonist with an IC₅₀ of 1 nM. AZ10397767 attenuates the Oxaliplatin (HY-17371)-induced NF-κB transcriptional activity and potentiates Oxaliplatin-induced apoptosis in androgen-independent prostate cancer (AIPC) cells. AZ10397767 significantly inhibits neutrophil recruitment into tumors which then adversely affects tumor growth in vitro and in vivo.

HY-113439

12-HETE	Apoptosis	Inflammation/Immunology Cardiovascular Disease
12-HETE, a major metabolic product of arachidonic acid using 12-LOX catalysis, inhibits cell apoptosis in a dose-dependent manner. 12-HETE promotes the activation and nuclear translocation of NF-κB through the integrin-linked kinase (ILK) pathway.12-HETE has both anti-thrombotic and pro-thrombotic effects. 12-HETE is a neuromodulator.

HY-B0185AS1

Lidocaine-d6 hydrochloride Lignocaine-d₆ hydrochloride	Sodium Channel MEK ERK NF-κB Apoptosis	Cancer Cardiovascular Disease
Lidocaine-d₆ (hydrochloride) is deuterium labeled Lidocaine (hydrochloride). Lidocaine hydrochloride (Lignocaine hydrochloride) inhibits sodium channels involving complex voltage and using dependence[1]. Lidocaine hydrochloride decreases growth, migration and invasion of gastric carcinoma cells via up-regulating miR-145 expression and further inactivation of MEK/ERK and NF-κB signaling pathways. Lidocaine hydrochloride is an amide derivative and a agent to treat ventricular arrhythmia and an effective tumor-inhibitor[2].

HY-19918A

Anatabine dicitrate	NF-κB Amyloid-β nAChR	Inflammation/Immunology Neurological Disease
Anatabine dicitrate is a tobacco alkaloid that can cross the blood-brain barrier. Anatabine dicitrate is a potent α4β2 nAChR agonist. Anatabine dicitrate inhibits *NF-κB* activation lower amyloid-β (Aβ) production by preventing the β-cleavage of amyloid precursor protein (APP). Anatabine dicitrate has anti-inflammatory effects and has the potential for neurodegenerative disorders treatment.

HY-B0185S

Lidocaine-d10 N-Oxide	Sodium Channel MEK ERK NF-κB Apoptosis	Cancer Cardiovascular Disease
N-Oxide Lidocaine-d₁₀ is the deuterium labeled Lidocaine. Lidocaine (Lignocaine) inhibits sodium channels involving complex voltage and using dependence[1]. Lidocaine decreases growth, migration and invasion of gastric carcinoma cells via up-regulating miR-145 expression and further inactivation of MEK/ERK and NF-κB signaling pathways. Lidocaine is an amide derivative and has potential for the research of ventricular arrhythmia[2].

HY-N0631

Cornuside	p38 MAPK NF-κB	Inflammation/Immunology
Cornuside is a secoiridoid glucoside isolated from the fruit of Cornus officinalis Sieb. et Zucc., which is a traditional oriental medicine for treating inflammatory diseases and invigorating blood circulation. Cornuside inhibits mast cell-mediated allergic response by down-regulating MAPK and *NF-κB* signaling pathways. Cornuside has anti-allergic effects in vivo and in vitro which suggests a therapeutic application of this agent in inflammatory allergic diseases.

HY-146564

R-HP210	NF-κB	Inflammation/Immunology
R-HP210 acts on the *NF-κB* mediated tethered transrepression function (IC₅₀=3.80 μM). R-HP210 represses the LPS-induced transcription of a variety of proinflammatory genes such as IL-1β, IL-6 and COX-2. R-HP210 does not induce the transactivation functions of Glucocorticoids (GCs).

HY-110247

TRAF-STOP inhibitor 6877002	TNF Receptor NF-κB	Inflammation/Immunology Cardiovascular Disease
TRAF-STOP inhibitor 6877002, is a selective inhibitor of CD40-TRAF6 interaction, compound VII, shows inhibition of *NF-κB* activation in RAW cells, extracted from patent WO2014033122A1. TRAF-STOP 6877002 prevents the progression of established atherosclerosis in mice, reduces leukocyte recruitment and reduces macrophage activation; reduces macrophage proliferation in atherosclerotic plaques.

HY-114454

INH14	IKK	Cancer Inflammation/Immunology
INH14 is a cell permeable inhibitor of IKKα/IKKβ, with IC₅₀s of 8.97 and 3.59 μM, respectively. INH14 inhibits the IKKα/β-dependent TLR inflammatory response. INH14 also inhibits downstream of TAK1/TAB1 and NF-kB pathways. Anti-inflammatory and anti-cancer activity.

HY-N2453

Convallatoxin	PPAR NF-κB P-glycoprotein	Cancer Inflammation/Immunology
Convallatoxin is a cardiac glycoside isolated from Adonis amurensis Regel et Radde. Convallatoxin ameliorates colitic inflammation via activation of PPARγ and suppression of *NF-κB*. Convallatoxin is a P-glycoprotein (P-gp) substrate and recognized Val982 as an important amino acid involved in its transport. Convallatoxin is an enhancer of ligand-induced MOR endocytosis with high potency and efficacy. Anti-inflammatory and anti-proliferative properties.

HY-W062904

Laquinimod sodium ABR-215062 sodium	NF-κB Apoptosis	Inflammation/Immunology Neurological Disease
Laquinimod (ABR-215062) sodium, an orally available carboxamide derivative, is a potent immunomodulator which prevents neurodegeneration and inflammation in the central nervous system. Laquinimod sodium reduces astrocytic *NF-κB* activation to protect from Cuprizone-induced demyelination. Laquinimod sodium has the potential for relapsing remitting (RR) and chronic progressive (CP) forms of multiple sclerosis (MS; RRMS or CPMS) as well as neurodegenerative diseases research.

HY-151966

TD1092	PROTACs IAP Caspase	Cancer
TD1092 is a pan-IAP degrader, degrades cIAP1, cIAP2, and XIAP. TD1092 activates Caspase 3/7, and promotes cancer cells apoptosis via IAP degradation. TD1092 inhibits TNFα mediated *NF-κB* pathway and reduces the phosphorylation of IKK, IkBα, p65, and p38. TD1092 can act as PROTAC, and is used for cancer research.

HY-19356

Rocaglamide Roc-A	NF-κB HSP Eukaryotic Initiation Factor (eIF)	Cancer
Rocaglamide (Roc-A) is isolated from the genus Aglaia and can be used for coughs, injuries, asthma and inflammatory skin diseases. Rocaglamide is a potent inhibitor of *NF-κB* activation in T-cells. Rocaglamide is a potent and selective heat shock factor 1 (HSF1) activation inhibitor with an IC₅₀ of ~50 nM. Rocaglamide inhibits the function of the translation initiation factor eIF4A. Rocaglamide also has anticancer properties in leukemia.

HY-P1259

PR-39	Proteasome Bacterial	Inflammation/Immunology
PR-39, a natural proline- and arginine-rich antibacterial peptide, is a noncompetitive, reversible and allosteric proteasome inhibitor. PR-39 reversibly binds to the α7 subunit of the proteasome and blocks degradation of NF-κB inhibitor IκBα by the ubiquitin-proteasome pathway. PR-39 stimulates angiogenesis, inhibits inflammatory responses and significant reduces myocardial infarct size in mice.

HY-13010

Laquinimod ABR-215062	NF-κB Apoptosis	Inflammation/Immunology
Laquinimod (ABR-215062), an orally available carboxamide derivative, is a potent immunomodulator which prevents neurodegeneration and inflammation in the central nervous system. Laquinimod reduces astrocytic *NF-κB* activation to protect from Cuprizone-induced demyelination. Laquinimod has the potential for relapsing remitting (RR) and chronic progressive (CP) forms of multiple sclerosis (MS; RRMS or CPMS) as well as neurodegenerative diseases research.

HY-N0603

20(S)-Ginsenoside Rg3 20(S)-Propanaxadiol; S-ginsenoside Rg3	Sodium Channel Potassium Channel NF-κB COX Amyloid-β Endogenous Metabolite	Cancer Inflammation/Immunology Neurological Disease
20(S)-Ginsenoside Rg3 is the main component of Panax ginseng C. A. Meyer. Ginsenoside Rg3 inhibits Na⁺ and hKv1.4 channel with IC₅₀s of 32.2±4.5 and 32.6±2.2 μM, respectively. 20(S)-Ginsenoside Rg3 also inhibits Aβ levels, *NF-κB* activity, and COX-2 expression.

HY-N6727

Gliotoxin Aspergillin	Apoptosis PKA NF-κB Bacterial Fungal Antibiotic	Infection Inflammation/Immunology
Gliotoxin is a secondary metabolite, the most abundant mycotoxin secreted by A. fumigatus, inhibits the phagocytosis of macrophages and the immune functions of other immune cells . Gliotoxin inhibits inducible *NF-κB* activity by preventing IκB degradation, which consequently induces host-cell apoptosis. Gliotoxin activates PKA and increases intracellular cAMP concentration; modulates actin cytoskeleton rearrangement to facilitate A. fumigatus internalization into lung epithelial cells.

HY-110177

SP-100030	NF-κB	Inflammation/Immunology
SP-100030 is a potent *NF-κB* and activator protein-1 (AP-1) double inhibitor (IC₅₀s=50 and 50 nM, respectively). SP-100030 inhibits IL-2, IL-8, and TNF-alpha production in Jurkat and other T cell lines. SP-100030 decreases murine collagen-induced arthritis (CIA).

HY-N2205

Esculentoside H	NF-κB JNK	Cancer
Esculentoside H (EsH) is a saponin isolated from the root extract of perennial plant Phytolacca esculenta. Esculentoside H (EH) has anti-tumor activity, the mechanism is related to the capacity for TNFrelease. Esculentoside H (EsH) suppresses colon cancer cell migration through blockage of the JNK1/2 and *NF-κB* signaling-mediated matrix metalloproteinases-9 (MMP-9) expression.

HY-108039

HE 3286 NE-3107	NF-κB	Metabolic Disease Inflammation/Immunology Neurological Disease
HE 3286 is a synthetic derivative of a natural anti-inflammatory steroid, β-AET. HE 3286 is an orally active partial *NF-κB* inhibitor. HE3286 reduces proinflammatory signals, including IL-6 and matrix metallopeptidase 3. HE 3286 freely penetrates the blood brain barrier in mice. HE 3286 can be used for the research of the ulcerative colitis, arthritis, experimental autoimmune encephalomyelitis.

HY-P1259A

PR-39 TFA	Proteasome Bacterial	Inflammation/Immunology
PR-39 TFA, a natural proline- and arginine-rich antibacterial peptide, is a noncompetitive, reversible and allosteric proteasome inhibitor. PR-39 TFAreversibly binds to the α7 subunit of the proteasome and blocks degradation of NF-κB inhibitor IκBα by the ubiquitin-proteasome pathway. PR-39 TFA stimulates angiogenesis, inhibits inflammatory responses and significant reduces myocardial infarct size in mice.

HY-145532

S-Allylmercaptocysteine	Apoptosis NF-κB Keap1-Nrf2	Cancer Inflammation/Immunology
S-allylmercaptocysteine, an organic sulfur compound extracted from garlic, has anti-inflammatory and anti-oxidative effects for various pulmonary diseases. S-allylmercaptocysteine achieves its anti-cancer effect through a variety of pathways such as inducing the apoptosis of cancer cells through the TGF-β signaling pathway, or reducing the NF-κB activity and up-regulating Nrf2 to achieve the effects of anti-inflammation and anti-oxidation.

HY-15131

PNRI-299	Interleukin Related	Inflammation/Immunology
PNRI-299 is a selective AP-1 transcription inhibitor with an IC₅₀ of 20 uM. PNRI-299 is a selective APE/Ref-1 inhibitor. PNRI-299 has no effect on NF-κB transcription or thioredoxin (up to 200 uM). PNRI-299 significantly reduces airway eosinophil infiltration, mucus hypersecretion, edema, and IL-4 levels in a mouse asthma model.

HY-146561

S-HP210	Glucocorticoid Receptor NF-κB	Inflammation/Immunology
S-HP210 is a potent and selective glucocorticoid receptor (GR) with an IC₅₀ value of 1.92 μM for NF-κB transrepression (TR). S-HP210 represses the LPS-induced transcription of a variety of proinflammatory genes such as IL-1β, IL-6 and COX-2. S-HP210 is nontoxic at effective doses against mouse fibroblasts 3T3 cells.

HY-W018772S15

D-Ribose(mixture of isomers)-13c5	Endogenous Metabolite
D-Ribose(mixture of isomers)-¹³C₅ isomers)-¹³C₅ is the ¹³C labeled D-Ribose(mixture of isomers)[1]. D-Ribose(mixture of isomers) is an energy enhancer, and acts as a sugar moiety of ATP, and widely used as a metabolic therapy supplement for chronic fatigue syndrome or cardiac energy metabolism. D-Ribose(mixture of isomers) is active in protein glycation, induces NF-κB inflammation in a RAGE-dependent manner[1].

HY-120323

DRI-C21045	TNF Receptor	Inflammation/Immunology
DRI-C21045 (compound 10) is a potent and selective inhibitor of the CD40-CD40L costimulatory protein-protein interaction (PPI) with an IC₅₀ of 0.17 µM. DRI-C21045 shows concentration-dependent inhibition of the activation of NF-κB and B cell proliferation all induced by CD40L with IC₅₀s of 17.1 µM and 4.5 µM, respectively.

HY-B2163

Astaxanthin	PPAR Reactive Oxygen Species STAT NF-κB Apoptosis	Cancer Metabolic Disease Cardiovascular Disease
Astaxanthin, the red dietary carotenoid, is an orally effective and potent antioxidant. Astaxanthin inhibits *NF-κB* and down-regulates VEGF in blood glucose. Astaxanthin exerts anti-cancer cell proliferation, increases apoptosis, impairs migration and invasion by activating PPARγ and reducing the expression of STAT3. Astaxanthin also has neuroprotective and anti-inflammatory activity and can be used in studies of cancer, diabetic retinopathy, cardiovascular disease, and in the coloring of animal feed.

HY-N0498

Nitidine chloride	Parasite Apoptosis STAT Topoisomerase ERK FAK p38 MAPK NF-κB	Cancer Inflammation/Immunology
Nitidine chloride, a potential anti-malarial lead compound derived from Zanthoxylum nitidum (Roxb) DC, exerts potent anticancer activity through diverse pathways, including inducing apoptosis, inhibiting STAT3 signaling cascade, DNA topoisomerase 1 and 2A, ERK and c-Src/FAK associated signaling pathway. Nitidine chloride inhibits LPS-induced inflammatory cytokines production via MAPK and *NF-kB* pathway.

HY-15186

Ipatasertib GDC-0068; RG7440	Akt Apoptosis	Cancer
Ipatasertib (GDC-0068) is an orally active, highly selective and ATP-competitive pan-Akt inhibitor with IC₅₀ values of 5, 18, 8 nM for Akt1/2/3, respectively. Ipatasertib synchronously activates FoxO3a and NF-κB through inhibition of Akt leading to p53-independent activation of PUMA. Ipatasertib also induces apoptosis in cancer cells and inhibits tumor growth in xenograft mouse models.

HY-19357

E3330 APX-3330	DNA/RNA Synthesis NF-κB AP-1 HIF/HIF Prolyl-Hydroxylase VEGFR Reactive Oxygen Species	Cancer Neurological Disease Cardiovascular Disease
E3330 (APX-3330) is a direct, orally active and selective inhibitor of Ape-1 (apurinic/apyrimidinic endonuclease 1)/Ref-1 (redox factor-1) redox. E3330 is able to impair tumor growth and blocks the activity of *NF-κB, AP-1, and HIF-1α* in pancreatic cancer. E3330 shows anticancer activities.

HY-146346

HD-TAC7	PROTACs HDAC	Inflammation/Immunology
HD-TAC7 is a potent PROTAC HDAC degrader with IC₅₀ values of 3.6 μM, 4.2 μM and 1.1 μM for HDAC1, HDAC2 and HDAC3, respectively. HD-TAC7 can decreases NF-κB p65 in RAW 264.7 macrophages. HD-TAC7 can be used for the research of inflammatory diseases like asthma and chronic obstructive pulmonary disease (COPD).

HY-N1326

Santamarine Santamarin; Balchanin	Others	Inflammation/Immunology
Santamarine (Santamarin), a sesquiterpene lactone, increases HO-1 expression through Nrf2 translocation and suppresses NO, PGE2, TNF-α, and IL-1β production through inhibition of NF-κB translocation in LPS-induced macrophages. Santamarine shows anti-photoaging properties via inhibition of MAPK/AP-1 and stimulation of TGF-β/Smad signaling in UVA-irradiated human dermal fibroblasts (HDFs). Antioxidant activities.

HY-N0822

Shikonin C.I. 75535; Isoarnebin 4	Chloride Channel Pyruvate Kinase NF-κB TNF Receptor HIV AIM2	Cancer
Shikonin is a major component of a Chinese herbal medicine named zicao. Shikonin is a potent TMEM16A chloride channel inhibitor with an IC₅₀ of 6.5 μM. Shikonin is a specific pyruvate kinase M2 (PKM2) inhibitor and can also inhibit TNF-α and *NF-κB* pathway. Shikonin decreases exosome secretion through the inhibition of glycolysis. Shikonin inhibits AIM2 inflammasome activation.

HY-122882

HOIPIN-8	E1/E2/E3 Enzyme	Inflammation/Immunology
HOIPIN-8 is a potent inhibitor of linear ubiquitin chain assembly complex (LUBAC) with an IC₅₀ of 11 nM. HOIPIN-8 is a HOIPIN-1 derivative with enhanced the potency by 255-fold in the petit-LUBAC inhibition, and 10-fold and 4-fold in the LUBAC- and TNF-α-mediated NF-κB activation, respectively than HOIPIN-1. HOIPIN-1 is a promising tool to explore the cellular functions of LUBAC.

HY-N2056

11-Keto-beta-boswellic acid 11-Keto-β-boswellic acid	Lipoxygenase Leukotriene Receptor NF-κB	Cancer
11-Keto-beta-boswellic acid (11-Keto-β-boswellic acid) is a pentacyclic triterpenic acid of the oleogum resin from the bark of the Boswellia serrate tree, popularly known as Indian Frankincense. 11-Keto-beta-boswellic acid has the anti-inflammatory activity is primarily due to inhibit 5-lipoxygenase (5-LOX) and subsequent leukotriene and nuclear factor-kappa B (NF-κB) activation and tumor necrosis factor alpha generation production.

HY-N0751

Scutellarin	STAT Akt HIV	Cancer Infection
Scutellarin, an active flavone isolated from Scutellaria baicalensis, can down-regulates the STAT3/Girdin/Akt signaling in HCC cells, and inhibits RANKL-mediated MAPK and NF-κB signaling pathway in osteoclasts. Scutellarin is active against HIV-1IIIB, HIV-1(74V) and HIV-1KM018 with EC₅₀s of 26 μM, 253 μM and 136 μM, respectively.

HY-N0619

Mulberroside A	TNF Receptor Interleukin Related Tyrosinase	Inflammation/Immunology
Mulberroside A is one of the main bioactive constituent in mulberry (Morus alba L.). Mulberroside A decreases the expressions of TNF-α, IL-1β, and IL-6 and inhibits the activation of NALP3, caspase-1, and NF-κB and the phosphorylation of ERK, JNK, and p38, exhibiting anti-inflammatory antiapoptotic effects. Mulberroside A shows inhibitory activity against mushroom tyrosinase with an IC₅₀ of 53.6 μM.

HY-N0005

Curcumin Diferuloylmethane; Natural Yellow 3; Turmeric yellow	Histone Acetyltransferase Epigenetic Reader Domain Keap1-Nrf2 Autophagy Mitophagy Influenza Virus Ferroptosis	Cancer
Curcumin (Diferuloylmethane), a natural phenolic compound, is a p300/CREB-binding protein-specific inhibitor of acetyltransferase, represses the acetylation of histone/nonhistone proteins and histone acetyltransferase-dependent chromatin transcription. Curcumin shows inhibitory effects on *NF-κB* and MAPKs, and has diverse pharmacologic effects including anti-inflammatory, antioxidant, antiproliferative and antiangiogenic activities. Curcumin induces stabilization of Nrf2 protein through Keap1 cysteine modification.

HY-139719

IMD-biphenylC	NF-κB	Inflammation/Immunology
IMD-biphenylC is a novel imidazoquinolinone-NF-κB immunomodulator dimer that inhibits tumor proliferation while induces low systemic inflammation and reduces adjuvant toxicity.

HY-139718

IMD-biphenylB	NF-κB	Inflammation/Immunology
IMD-biphenylB is a potent imidazoquinolinone-NF-κB immunomodulator dimer that inhibits tumor proliferation while induces low systemic inflammation and reduces adjuvant toxicity.

HY-136718

CLEFMA	Apoptosis	Cancer
CLEFMA is a curcuminoid with antitumor activity. CLEFMA inhibits tumor growth is associated with NF-κB-regulated anti-inflammatory and anti-metastatic effects.

HY-107909

Theophylline sodium glycinate 1,3-Dimethylxanthine sodium glycinate; Theo-24 sodium glycinate	Adenosine Receptor HDAC Apoptosis Interleukin Related TNF Receptor	Cancer
Theophylline (1,3-Dimethylxanthine) sodium glycinate is a potent phosphodiesterase (PDE) inhibitor, adenosine receptor antagonist, and histone deacetylase (HDAC) activator. Theophylline sodium glycinate inhibits PDE3 activity to relax airway smooth muscle. Theophylline sodium glycinate has anti-inflammatory activity by increase IL-10 and inhibit NF-κB into the nucleus. Theophylline sodium glycinate induces apoptosis. Theophylline sodium glycinate can be used for asthma and chronic obstructive pulmonary disease (COPD) research.

HY-13811

NSC697923	E1/E2/E3 Enzyme Apoptosis	Cancer
NSC697923 is a potent UBE2N (ubiquitin-conjugating enzyme E2 N, Ubc13) inhibitor. NSC697923 induces neuroblastoma (NB) cell death via promoting nuclear importation of p53 in p53 wild-type NB cells. NSC697923 also induces cell death in p53 mutant NB cells by activation of JNK-mediated apoptotic pathway. NSC697923 inhibits DNA damage and NF-κB signaling. Antitumor activity.

HY-123942

Diprovocim	Toll-like Receptor (TLR) TNF Receptor p38 MAPK NF-κB	Cancer Inflammation/Immunology
Diprovocim is a potent TLR1/TLR2 agonist. Diprovocim elicits full agonist activity in human THP-1 cells (EC₅₀=110 pM). Diprovocim stimulates the release of TNF-α from mouse macrophages (EC₅₀=1.3 nM). Diprovocim activates downstream MAPK and *NF-κB* signaling pathway. Diprovocim displays strong adjuvant activity in mice, particularly abetting cellular immune responses.

HY-N3364

Lucidone	TNF Receptor NF-κB NO Synthase COX JNK p38 MAPK IKK	Infection Inflammation/Immunology
Lucidone, an anti-inflammatory agent that can be isolated from the fruit of Lindera erythrocarpa Makino. Lucidone inhibits LPS-induced NO and PGE₂ production in RAW 264.7 mouse macrophages. Lucidone also decreases TNF-α secretion, iNOS and COX-2 expression. Lucidone prevents *NF-κB* translocation and inhibits JNK and p38MAPK signals. Lucidone also has inhibitory activity against Dengue virus (DENV) (EC₅₀=25 μM).

HY-148552

Anti-inflammatory agent 35	p38 MAPK ERK NF-κB Interleukin Related TNF Receptor	Inflammation/Immunology
Anti-inflammatory agent 35 (compound 5a27) is an orally active curcumin analogue with anti-inflammatory activity. Anti-inflammatory agent 35 blocks mitogen-activated protein kinase (MAPK) signaling and p65 nuclear translocation of NF-kB. Anti-inflammatory agent 35 also inhibits yellow neutrophil infiltration and pro-inflammatory cytokine production. Anti-inflammatory agent 35 significantly attenuates lipopolysaccharide (LPS)-induced acute lung injury (ALI) in vivo.

HY-N3807

Enniatin B1	Acyltransferase ERK NF-κB	Cancer Infection Cardiovascular Disease
Enniatin B1 is a Fusarium mycotoxin. Enniatin B1 inhibits acyl-CoA: cholesterol acyltransferase (ACAT) activity with an IC₅₀ of 73 μM in an enzyme assay using rat liver microsomes. Enniatin B1 crosss the blood-brain barrier. Enniatin B1 decreases the activation of ERK (p44/p42). Enniatin B1 inhibits moderately TNF-α-induced *NF-κB* activation.

HY-W012977

3,3-Dimethyl-1-butanol DMB; Neohexanol	TGF-beta/Smad NF-κB Endogenous Metabolite	Metabolic Disease Inflammation/Immunology Cardiovascular Disease
3,3-Dimethyl-1-butanol (DMB) is an orally active inhibitor of trimethylamine (TMA) and trimethylamine N-oxide (TMAO). 3,3-Dimethyl-1-butanol inhibits the signaling pathway of p65 NF-κB and TGF-β1/Smad3. 3,3-Dimethyl-1-butanol has potential applications in cardiovascular disease (CVD).

HY-16591

Birinapant TL32711	IAP Apoptosis HIV	Cancer
Birinapant (TL32711), a bivalent Smac mimetic, is a potent antagonist for XIAP and cIAP1 with K_ds of 45 nM and less than 1 nM, respectively. Birinapant (TL32711) induces the autoubiquitylation and proteasomal degradation of cIAP1 and cIAP2 in intact cells, which results in formation of a RIPK1: caspase-8 complex, caspase-8 activation, and induction of tumor cell death. Birinapant (TL32711) targets TRAF2-associated cIAPs and abrogates TNF-induced NF-κB activation.

HY-139844

Anti-inflammatory agent 7	p38 MAPK NF-κB	Inflammation/Immunology
Anti-inflammatory agent 7 inhibits proinflammatory cytokines by blocking the *NF-κB/MAPK* signaling pathway in LPS-treated RAW 264.7 cells as well as mice.

HY-139716

IMD-catechol	NF-κB	Inflammation/Immunology
IMD-catechol is a novel imidazoquinolinone-NF-κB immunomodulator dimer that improves efficacy in a CT26 mouse colon carcinoma tumor model while eliciting minimal adjuvant toxicity.

HY-N4314

Scutellarein tetramethyl ether 4',5,6,7-Tetramethoxyflavone	Bacterial	Infection Inflammation/Immunology
Scutellarein tetramethyl ether (4',5,6,7-Tetramethoxyflavone) is a bioactive component of Siam weed extract. Scutellarein tetramethyl ether (4',5,6,7-Tetramethoxyflavone) exhibits anti-inflammatory activity through NF-κB pathway. Scutellarein tetramethyl ether (4',5,6,7-Tetramethoxyflavone) modulats of bacterial agent resistance via efflux pump inhibition. Scutellarein tetramethyl ether (4',5,6,7-Tetramethoxyflavone) can enhance blood coagulation.

HY-113439S

12-HETE-d8	Apoptosis	Inflammation/Immunology Cardiovascular Disease
12-HETE-d₈ is the deuterium labeled 12-HETE. 12-HETE, a major metabolic product of arachidonic acid using 12-LOX catalysis, inhibits cell apoptosis in a dose-dependent manner. 12-HETE promotes the activation and nuclear translocation of NF-κB through the integrin-linked kinase (ILK) pathway[1].12-HETE has both anti-thrombotic and pro-thrombotic effects[2]. 12-HETE is a neuromodulator[3].

HY-123295

HDAC3-IN-T247	HDAC	Cancer Infection
HDAC3-IN-T247 is a potent and selective HDAC3 (histone deacetylase 3) inhibitor, with an IC₅₀ of 0.24 µM. HDAC3-IN-T247 induces a selective increase of NF-κB acetylation in HCT116 cells. HDAC3-IN-T247 shows anticancer and antiviral activity. HDAC3-IN-T247 inhibits growth of cancer cells, and activates HIV gene expression in latent HIV-infected cells.

HY-N0811

Anemarsaponin B	NO Synthase COX NF-κB MEK	Inflammation/Immunology
Anemarsaponin B is a steroidal saponin. Anemarsaponin B decreases the protein and mRNA levels of iNOS and COX-2. Anemarsaponin B reduces the expressions and productions of pro-inflammatory cytokines, including TNF-a and IL-6. Anemarsaponin B inhibits the nuclear translocation of the p65 subunit of *NF-κB* by blocking the phosphorylation of IκBα. Anemarsaponin B also inhibits the phosphorylation of MAP kinase kinases 3/6 (MKK3/6) and mixed lineage kinase 3 (MLK3). Anti-inflammatory effect .

HY-N6257

Cafestol	ERK PGE synthase COX NF-κB	Cancer Inflammation/Immunology
Cafestol, one of the major components of coffee, is a coffee-specific diterpene from. Cafestol is a ERK inhibitor for AP-1-targeted activity against PGE₂ production and the mRNA expression of cyclooxygenase (COX)-2 in LPS-activated RAW264.7 cells. Cafestol has strong inhibitory activity on PGE₂ production by suppressing the *NF-kB* activation pathway. Cafestol contributes to its beneficial effects through various biological activities such as chemopreventive, antitumorigenic, hepatoprotective, antioxidative and antiinflammatory effects.

HY-N0632

Esculentoside A	COX NF-κB	Inflammation/Immunology
Esculentoside A (EsA), a kind of triterpene saponin isolated from roots of Phytolacca esculenta. Esculentoside A (EsA) possesses anti-inflammatory activity in acute and chronic experimental models, has selective inhibitory activity towards cyclooxygenase-2 (COX-2). Esculentoside A (EsA) suppresses inflammatory responses in LPS-induced acute lung injury (ALI) through inhibition of the nuclear factor kappa B (NF-ΚB) and mitogen activated protein kinase (MAPK) signaling pathways.

HY-N0619A

cis-Mulberroside A Mulberroside D	TNF Receptor Interleukin Related Tyrosinase	Inflammation/Immunology
cis-Mulberroside A (Mulberroside D) is the cis-isomer of Mulberroside A. Mulberroside A is one of the main bioactive constituent in mulberry (Morus alba L.). Mulberroside A decreases the expressions of TNF-α, IL-1β, and IL-6 and inhibits the activation of NALP3, caspase-1, and NF-κB and the phosphorylation of ERK, JNK, and p38, exhibiting anti-inflammatory and anti-apoptotic effects. Mulberroside A shows inhibitory activity against mushroom tyrosinase with an IC₅₀ of 53.6 μM.

HY-12687

Tizoxanide TIZ	Bacterial HIV Autophagy Parasite IKK Influenza Virus	Cancer Infection
Tizoxanide (TIZ) is the active metabolite of Nitazoxanide, which is a thiazolide anti-infective compound against anaerobic bacteria, protozoa, and a range of viruses. Tizoxanide (TIZ) has anti-HIV-1 activities and potent inhibition of both HBV and HCV replication with values EC₅₀ of 0.46μM and 0.15 μM, respectively. Tizoxanide also exerts anti-inflammatory effects by inhibiting the production of pro-inflammatory cytokines and suppressing of the activation of the NF-κB and the MAPK signaling pathways in LPS-treated macrophage cells.

HY-104073

CAY10602	Sirtuin	Metabolic Disease Inflammation/Immunology
CAY10602 is a SIRT1 activator. CAY10602 dose-dependently suppresses the NF-κB-dependent induction of TNF-α by lipopolysaccharide in THP-1 cells.

HY-N0755

Rhoifolin	Insulin Receptor GLUT NF-κB p38 MAPK Autophagy	Metabolic Disease Endocrinology Cancer
Rhoifolin is a flavone glycoside can be isolated from Rhus succedanea. Rhoifolin has anti-diabetic effect acting through enhanced adiponectin secretion, tyrosine phosphorylation of insulin receptor-β and glucose transporter 4 (GLUT 4) translocation. Rhoifolin has an anti-inflammatory action via multi-level regulation of inflammatory mediators. Rhoifolin ameliorates titanium particle-stimulated osteolysis and attenuates osteoclastogenesis via RANKL-induced *NF-κB* and MAPK pathways. Rhoifolin also has cytotoxic activity against different cancer cell lines.

HY-N1445

Isoquercetin Quercetin 3-glucoside	NF-κB NO Synthase	Inflammation/Immunology Cancer
Isoquercetin (Quercetin 3-glucoside) is a naturally occurring polyphenol that has antioxidant, anti-proliferative, and anti-inflammatory properties. Isoquercetin alleviates ethanol-induced hepatotoxicity, oxidative stress, and inflammatory responses via the Nrf2/ARE antioxidant signaling pathway. Isoquercetin regulates the expression of nitric oxide synthase 2 (NO2) via modulating the nuclear factor-κB (NF-κB) transcription regulation system. Isoquercetin has high bioavailability and low toxicity, is a promising candidate agent to prevent birth defects in diabetic pregnancies.

HY-110353

CU-T12-9	Toll-like Receptor (TLR)	Cancer Inflammation/Immunology
CU-T12-9 is a specific TLR1/2 agonist with EC₅₀ of 52.9 nM in HEK-Blue hTLR2 SEAP assay. CU-T12-9 activates both the innate and the adaptive immune systems. CU-T12-9 selectively activates the TLR1/2 heterodimer, not TLR2/6. CU-T12-9 signals through NF-κB and invokes an elevation of the downstream effectors TNF-α, IL-10, and iNOS.

HY-N0408

Picroside II	NF-κB Reactive Oxygen Species Apoptosis Influenza Virus	Cancer Infection Inflammation/Immunology Neurological Disease
Picroside II, an iridoid compound extracted from Picrorhiza, exhibits anti-inflammatory and anti-apoptotic activities. picroside II alleviates the inflammatory response in sepsis and enhances immune function by inhibiting the activation of NLRP3 inflammasome and *NF-κB* pathways. Picroside II is an antioxidant, exhibits a significant neuroprotective effect through reducing ROS production and protects the blood-brain barrier (BBB) after cerebral ischemia-reperfusion (CI/R) injury. Picroside II has antioxidant, anti-inflammatory, immune regulatory, anti-virus and other pharmacological activities.

HY-143243

Antioxidant agent-5	Apoptosis NF-κB Keap1-Nrf2 Reactive Oxygen Species	Cardiovascular Disease
Antioxidant agent-5 (compound D-6) is a potent antioxidant agent. Antioxidant agent-5 can inhibit oxLDL (oxidized low-density lipoprotein)-induced apoptosis and the expression of ICAM-1 and VCAM-1 in VECs. Antioxidant agent-5 suppresses oxLDL-induced increase of ROS level and nuclear translocation of *NF-κB. Antioxidant agent-5 protects against oxLDL-induced endothelial injury by activating Nrf2/HO-1* anti-oxidation pathway.

HY-120515

7-Oxostaurosporine	PKC	Cancer
7-Oxostaurosporine is a potent protein kinase C (PKC) inhibitor that effectively inhibits tumor growth by inducing apoptosis and inhibiting the nuclear factor (NF)-κB/p-p65 pathway.

HY-113509S

Lipoxin A4-d5 LXA4-d₅	Interleukin Related Endogenous Metabolite	Inflammation/Immunology
Lipoxin A4-d₅ is the deuterium labeled Lipoxin A4. Lipoxin A4 (LXA4), an endogenous lipoxygenase-derived eicosanoid mediator, has potent dual pro-resolving and anti-inflammatory properties[1]. Lipoxin A4 inhibits proliferation and inflammatory cytokine/chemokine production of human epidermal keratinocytes (NHEKs) associated with the ERK1/2 and NF-kB pathways[2]. Lipoxin A4 inhibits serum amyloid A (SAA)-mediated IL-8 release with an IC50 value of 25.74 nM[3].

HY-B0809A

Theophylline monohydrate 1,3-Dimethylxanthine monohydrate; Theo-24 monohydrate	Phosphodiesterase (PDE) Adenosine Receptor HDAC Apoptosis Interleukin Related TNF Receptor Endogenous Metabolite	Cancer
Theophylline (1,3-Dimethylxanthine) monohydrate is a potent phosphodiesterase (PDE) inhibitor, adenosine receptor antagonist, and histone deacetylase (HDAC) activator. Theophylline (1,3-Dimethylxanthine) monohydrate inhibits PDE3 activity to relax airway smooth muscle. Theophylline (1,3-Dimethylxanthine) monohydrate has anti-inflammatory activity by increase IL-10 and inhibit NF-κB into the nucleus. Theophylline (1,3-Dimethylxanthine) monohydrate induces apoptosis. Theophylline (1,3-Dimethylxanthine) monohydrate can be used for asthma and chronic obstructive pulmonary disease (COPD) research.

HY-19744

T6167923	MyD88	Inflammation/Immunology
T6167923 is a selective inhibitor of MyD88-dependent signaling pathways. T6167923 directly binds to Toll/IL1 receptor (TIR) domain of MyD88 and disrupts MyD88 homodimeric formation. T6167923 inhibits NF-κB driven Staphylococcus enterotoxin AP (SEAP) activity, and improves anti-inflammatory activity with IC₅₀s of 2.7 μM, 2.9 μM, 2.66 μM and 2.66 μM for IFN-γ, IL-1β, IL-6 and TNF-α, respectively.

HY-B0809

Theophylline 1,3-Dimethylxanthine; Theo-24	Phosphodiesterase (PDE) Adenosine Receptor HDAC Apoptosis Interleukin Related TNF Receptor Endogenous Metabolite	Cancer
Theophylline (1,3-Dimethylxanthine) is a potent phosphodiesterase (PDE) inhibitor, adenosine receptor antagonist, and histone deacetylase (HDAC) activator. Theophylline (1,3-Dimethylxanthine) inhibits PDE3 activity to relax airway smooth muscle. Theophylline (1,3-Dimethylxanthine) has anti-inflammatory activity by increase IL-10 and inhibit NF-κB into the nucleus. Theophylline (1,3-Dimethylxanthine) induces apoptosis. Theophylline (1,3-Dimethylxanthine) can be used for asthma and chronic obstructive pulmonary disease (COPD) research.

HY-B0809B

Theophylline sodium acetate 1,3-Dimethylxanthine sodium acetate; Theo-24 sodium acetate	Endogenous Metabolite Phosphodiesterase (PDE) Adenosine Receptor HDAC Apoptosis Interleukin Related TNF Receptor	Cancer
Theophylline (1,3-Dimethylxanthine) sodium acetate is a potent phosphodiesterase (PDE) inhibitor, adenosine receptor antagonist, and histone deacetylase (HDAC) activator. Theophylline (1,3-Dimethylxanthine) sodium acetate inhibits PDE3 activity to relax airway smooth muscle. Theophylline (1,3-Dimethylxanthine) sodium acetate has anti-inflammatory activity by increase IL-10 and inhibit NF-κB into the nucleus. Theophylline (1,3-Dimethylxanthine) sodium acetate induces apoptosis. Theophylline (1,3-Dimethylxanthine) sodium acetate can be used for asthma and chronic obstructive pulmonary disease (COPD) research.

HY-N0427

Phellodendrine	Akt NF-κB	Inflammation/Immunology
Phellodendrine, a isoquinoline alkaloid, is one of important characteristic ingredients in the Phellodendron amurense. phellodendrine is against AAPH-induced oxidative stress through regulating the *AKT/NF-κB* pathway. Phellodendrine has good antioxidant, and anti-inflammatory effect .

HY-108534

PMX464 AW 464	TrxR	Cancer Inflammation/Immunology
PMX464 (AW 464), a thiol-reactive quinol, is the inhibitor of thioredoxin-thioredoxin reductase (Trx/TrxR) system. PMX464 can inhibit NF-κB-mediated proinflammatory activation of human type II alveolar epithelial cells.

HY-121607

INI-43
Others Cancer

INI-43, a Kpnβ1 inhibitor, interferes with the nuclear localization of Kpnβ1 and known Kpnβ1 cargoes, NFAT, NFκB, AP-1 and NFY.

HY-N0515

Ophiopogonin D	PPAR NF-κB Calcium Channel	Inflammation/Immunology Cardiovascular Disease
Ophiopogonin D, isolated from the tubers of Ophiopogon japonicus, is a rare naturally occurring C₂₉ steroidal glycoside. Ophiopogonin D is a CYP2J3 inducer that significantly inhibits Ang II induced NF-κB nuclear translocation, IκBα down-regulation, intracellular Ca²⁺ overload and activation of pro-inflammatory cytokines by increasing the expression of CYP2J2/EETs and PPARα in human umbilical vein endothelial cells (HUVECs). Ophiopogonin D has been used to treat inflammatory and cardiovascular diseases for thousands of years.

HY-W016412

Coenzyme Q0 CoQ0	Apoptosis Autophagy EGFR Akt mTOR Caspase Bcl-2 Family Reactive Oxygen Species PARP COX NO Synthase TNF Receptor Interleukin Related MMP NF-κB	Cancer Inflammation/Immunology Neurological Disease
Coenzyme Q0 (CoQ0) is a potent, oral active ubiquinone compound can be derived from Antrodia cinnamomea. Coenzyme Q0 induces apoptosis and autophagy, suppresses of HER-2/AKT/mTOR signaling to potentiate the apoptosis and autophagy mechanisms. Coenzyme Q0 regulates NFκB/AP-1 activation and enhances Nrf2 stabilization in attenuation of inflammation and redox imbalance. Coenzyme Q0 has anti-angiogenic activity through downregulation of MMP-9/NF-κB and upregulation of HO-1 signaling.

HY-N0373

Licochalcone B	Amyloid-β Apoptosis NOD-like Receptor (NLR)	Neurological Disease
Licochalcone B is an extract from the root of Glycyrrhiza uralensis. Licochalcone B inhibits amyloid β (₄₂) self-aggregation (IC₅₀=2.16 μM) and disaggregate pre-formed Aβ₄₂ fibrils, reduce metal-induced Aβ₄₂ aggregation through chelating metal ionsLicochalcone B inhibits phosphorylation of NF-κB p65 in LPS signaling pathway. Licochalcone B inhibits growth and induces apoptosis of NSCLC cells. Licochalcone B specifically inhibits the NLRP3 inflammasome by disrupting NEK7‐NLRP3 interaction.

HY-N0043

Ginsenoside Rd Gypenoside VIII	NF-κB COX Calcium Channel Cytochrome P450 Endogenous Metabolite	Inflammation/Immunology Cardiovascular Disease Cancer
Ginsenoside Rd inhibits TNFα-induced *NF-κB* transcriptional activity with an IC₅₀ of 12.05±0.82 μM in HepG2 cells. Ginsenoside Rd inhibits expression of COX-2 and iNOS mRNA. Ginsenoside Rd also inhibits Ca²⁺ influx. Ginsenoside Rd inhibits CYP2D6, CYP1A2, CYP3A4, and CYP2C9, with IC₅₀s of 58.0±4.5 μM, 78.4±5.3 μM, 81.7±2.6 μM, and 85.1±9.1 μM, respectively.

HY-N10106

Dihydromyristicin	Reactive Oxygen Species	Inflammation/Immunology
Dihydromyristicin, a plant flavonoid, has potent anti-inflammatory properties. Dihydromyristicin reduces endotoxic inflammation via repressing ROS-mediated activation of PI3K/Akt/NF-κB signaling pathways.

HY-120501

B022	NF-κB	Inflammation/Immunology
B022 is a potent and selective NF-κB-inducing kinase (NIK) inhibitor (K_i of 4.2 nM; IC₅₀=15.1 nM). B022 protects liver from toxin-induced inflammation, oxidative stress, and injury.

HY-N0705

Curculigoside	JAK STAT NF-κB	Inflammation/Immunology Neurological Disease Cancer
Curculigoside is the main saponin in C. orchioide, exerts significant antioxidant, anti-osteoporosis, antidepressant and neuroprotection effects. Curculigoside possesses significant anti-arthritic effects in vivo and in vitro via regulation of the *JAK/STAT/NF-κB* signaling pathway.

HY-B1460B

Sulconazole (±)-Sulconazole	Fungal	Cancer
Sulconazole is a potent antifungal agent in the imidazole class. Sulconazole blocks the NF-κB/IL-8 signaling pathway and CSC (Cancer stem cells) formation. Sulconazole inhibits tumor growth, and can be used for breast cancer research.

HY-N0617

Sanggenon C	NF-κB	Cancer Inflammation/Immunology Cardiovascular Disease
Sanggenon C is a flavanone Diels-Alder adduct compound, which is isolated from Cortex Mori (Sang Bai Pi). Sanggenon C exerts protective effects against cardiac hypertrophy and fibrosis via suppression of the calcineurin/NFAT2 pathway. Sanggenon C inhibits inducible nitric oxide synthase expression in RAW264.7 cells, and tumor necrosis factor-α-stimulated cell adhesion and vascular cell adhesion molecule-1 expression, by suppressing *NF-κB* activity. Sanggenon C possesses antioxidant, anti-inflammatory activities and inhibits Pancreatic lipase (PL) with the an IC₅₀ of 3.00 μM.

HY-131265

Mesalamine impurity P	PPAR PAK NF-κB	Cancer Inflammation/Immunology
Mesalamine impurity P is an impurity of Mesalamine (HY-15027). 5-Aminosalicylic acid (Mesalamine) acts as a specific PPARγ agonist and also inhibits p21-activated kinase 1 (PAK1) and NF-κB.

HY-110274

IP7e
Others Inflammation/Immunology

IP7e is a potent, brain-penetrant and orally active Nurr1 activator with an EC₅₀ value of 3.9 nM.

HY-N2485

4'-Methoxyresveratrol 4'-O-Methylresveratrol	NF-κB NOD-like Receptor (NLR)	Inflammation/Immunology
4'-Methoxyresveratrol (4'-O-Methylresveratrol) is a polyphenol derived from Dipterocarpaceae, with antiandrogenic, antifungal and anti-inflammatory activities. 4'-Methoxyresveratrol alleviates AGE-induced inflammation through suppressing RAGE-mediated MAPK/NF-κB signaling pathway and NLRP3 inflammasome activation.

HY-N2515

Ginsenoside Rk1	NF-κB PI3K JAK Apoptosis	Cancer Inflammation/Immunology
Ginsenoside Rk1 is a unique component created by processing the ginseng plant (mainly Sung Ginseng, SG) at high temperatures. Ginsenoside Rk1 has anti-inflammatory effect, suppresses the activation of Jak2/Stat3 signaling pathway and *NF-κB. Ginsenoside Rk1 has anti-tumor effect, antiplatelet aggregation activities, anti-insulin resistance, nephroprotective effect, antimicrobial effect, cognitive function enhancement, lipid accumulation reduction and prevents osteoporosis. Ginsenoside Rk1 induces cell apoptosis by triggering intracellular reactive oxygen species (ROS) generation and blocking PI3K/Akt* pathway.

HY-141645

IMM-H007 WS070117	AMPK TGF-β Receptor NF-κB JNK AP-1	Metabolic Disease Inflammation/Immunology Cardiovascular Disease
IMM-H007 (WS070117) is an orally active and potent AMPK (AMP-activated protein kinase) activator and TGFβ1 (transforming growth factor β1) antagonist. IMM-H007 has protective effects in cardiovascular diseases via activation of AMPK. IMM-H007 negatively regulates endothelium inflammation through inactivating *NF-κB* and JNK/AP1 signaling. IMM-H007 inhibits ABCA1 degradation. IMM-H007 resolves hepatic steatosis in HFD-fed hamsters by the regulation of lipid metabolism. IMM-H007 can be used for the research of nonalcoholic fatty liver disease (NAFLD) and inflammatory atherosclerosis.

HY-126397

MnTBAP chloride	NF-κB	Inflammation/Immunology
MnTBAP chloride is a superoxide dismutase (SOD) mimetic and peroxynitrite scavenger. MnTBAP chloride is a manganic porphyrin complex and has anti-oxidative property. MnTBAP chloride mediates anti-inflammatory effects through upregulation of BMPR-II and inhibition of the *NFκB* signaling. MnTBAP chloride has the potential for the fibrotic response in chronic kidney diseases (CKDs) research.

HY-N7043

Isosilybin A	Apoptosis	Cancer
Isosilybin A, a flavonolignan isolated from silymarin, has anti-prostate cancer (PCA) activity. Isosilybin A inhibits proliferation and induces G1 phase arrest and apoptosis in cancer cells, which activates apoptotic machinery in PCA cells via targeting *Akt-NF-κB-androgen receptor (AR)* axis.

HY-N2855

Alphitolic acid Aophitolic acid	Apoptosis Autophagy TNF Receptor Akt NF-κB	Cancer Inflammation/Immunology
Alphitolic acid (Aophitolic acid) is an anti-inflammatory triterpene could found in quercus aliena. Alphitolic acid blocks Akt–NF-κB signaling to induce apoptosis. Alphitolic acid induces autophagy. Alphitolic acid has anti-inflammatory activity and down-regulates the NO and TNF-α production. Alphitolic acid can be used for cancer and inflammation research.

HY-N0392

Polygalasaponin F	Toll-like Receptor (TLR) PI3K Akt NF-κB	Inflammation/Immunology
Polygalasaponin F, an oleanane-type triterpenoid saponin extracted from Polygala japonica, decreases the release of the inflammatory cytokine tumor necrosis factor a (TNFa). Polygalasaponin F reduces neuroinflammatory cytokine secretion through the regulation of the *TLR4-PI3K/AKT-NF-kB* signaling pathway .

HY-N2609

7,4'-Dihydroxyflavone	CCR NF-κB	Inflammation/Immunology Endocrinology
7,4'-Dihydroxyflavone (7,4'-DHF) is a flavonoid isolated from Glycyrrhiza uralensis, the eotaxin/CCL11 inhibitor, has the ability to consistently suppress eotaxin production and prevent dexamethasone (Dex)‐paradoxical adverse effects on eotaxin production. 7,4'-Dihydroxyflavone (7,4'-DHF) inhibits MUC5AC gene expression, mucus production and secretion via regulation of NF-κB, STAT6 and HDAC2. 7,4'-Dihydroxyflavone (7,4'-DHF) decreases phorbol 12-myristate 13-acetate (PMA) stimulated NCI-H292 human airway epithelial cell MUC5AC gene expression and mucus production with IC₅₀ value of 1.4 µM.

HY-136794

SB-284851-BT	p38 MAPK Epigenetic Reader Domain	Cancer Inflammation/Immunology
SB-284851-BT is an inhibitor of BRD4/p38α/BRDT. SB-284851-BT inhibits BRD4-BD1 (IC₅₀=1.7 µM), p38α (K_d=0.47 nM), BRDT (1) (IC₅₀=18 µM) and BRD4 (1)(IC₅₀=3.7 µM). SB-284851-BT reduces IL-8 production by inhibiting p38α, as well as inhibiting BRD4 to down-regulates c-Myc and *NF-κB* gene pathways in cancer. SB-284851-BT can combined with the bromine domain and extra terminal (BET).

HY-N3387

Licoricidin	Apoptosis NF-κB Akt MMP	Cancer Inflammation/Immunology
Licoricidin (LCD) is isolated from Glycyrrhiza uralensis Fisch, possesses anti-cancer activities. Licoricidin (LCD) inhibit SW480 cells (IC₅₀=7.2 μM) by inducing cycle arrest, apoptosis and autophagy, and is a potential chemopreventive or chemotherapeutic agent against colorectal cancer. Licoricidin (LCD) inhibits Lung Metastasis by inhibition of tumor angiogenesis and lymphangiogenesis as well as changes in the local microenvironment of tumor tissues the anticarcinogenic effect. Licoricidin enhanced gemcitabine-induced cytotoxicity in Osteosarcoma (OS) cells by inactivation of the Akt and *NF-κB* pathways in vitro and in vivo. Licoricidin blocks UVA-induced photoaging via ROS scavenging, limits the activity of MMP-1, it can be considered as an active ingredient in new topically applied anti-ageing formulations.

HY-N2573A

Corydalmine hydrochloride L-Corydalmine hydrochloride; TLZ-16-CL	Fungal CXCR	Infection Neurological Disease
Corydalmine hydrochloride inhibits spore germination of some plant pathogenic as well as saprophytic fungi. Corydalmine hydrochloride acts as an oral analgesic agent, exhibiting potent analgesic activity. Corydalmine hydrochloride alleviates Vincristine-induced neuropathic pain in mice by inhibiting an NF-κB-dependent CXCL1/CXCR2 signaling pathway.

HY-N2573

Corydalmine L-Corydalmine; TLZ-16	Fungal CXCR	Infection Neurological Disease
Corydalmine (L-Corydalmine) inhibits spore germination of some plant pathogenic as well as saprophytic fungi. Corydalmine acts as an oral analgesic agent, exhibiting potent analgesic activity. Corydalmine alleviates Vincristine-induced neuropathic pain in mice by inhibiting an NF-κB-dependent CXCL1/CXCR2 signaling pathway.

HY-N8707

Homobutein	Parasite HDAC NF-κB	Cancer Infection Inflammation/Immunology
Homobutein a natural chalcones (can be found in many medicinal plants, fruits, vegetables, spices and nuts), is a potent *HDACs/NF-κB* dual inhibitor with IC₅₀s of 190 and 38 μM, respectively. Homobutein also a chelator of iron (II and III) cations, shows various activities, including anticancer, anti-inflammatory, antiparasite and antioxidation.

HY-100233

IQ-1S free acid	JNK	Cancer Inflammation/Immunology
IQ-1S free acid is a prospective inhibitor of *NF-κB*/activating protein 1 (AP-1) activity with an IC₅₀ of 2.3±0.41 μM. IQ-1S free acid has binding affinity (K_d values) in the nanomolar range for all three JNKs with K_ds of 100 nM, 240 nM, and 360 nM for JNK3, JNK1, and JNK2, respectively.

HY-146421

Anti-inflammatory agent 21	NO Synthase NF-κB Reactive Oxygen Species	Inflammation/Immunology
Anti-inflammatory agent 21 (compound 9o) is an orally active and low cytotoxic anti-inflammatory agent, with an IC₅₀ value of 0.76 μM for NO. Anti-inflammatory agent 21 acts via accumulation ROS and blocks the *NF-κB/MAPK* signaling pathway. Anti-inflammatory agent 21 can ameliorate cartilage destruction and inflammatory cell infiltration in arthritis rats model.

HY-12383

Pelubiprofen	COX	Inflammation/Immunology Neurological Disease
Pelubiprofen, an orally active and non-steroidal anti-inflammatory drug, is a member of the 2-arylpropionic acid family and has relatively selective effects on COX-2 activity. Pelubiprofen inhibits COX activity and the transforming growth factor-β activated kinase 1-IκB kinase β-NF-κB pathway, and has significant anti-inflammatory and analgesic effects.

HY-141582

Ceramide 3 N-Stearoyl phytosphingosine	Biochemical Assay Reagents	Others
C18 Phytoceramide (t18:0/18:0) (Cer(t18:0/18:0)) is a bioactive sphingolipid found in the stratum corneum of Saccharomyces cerevisiae, wheat grain, and mammalian epidermis. Cer(t18:0/18:0) consists of a phytosphingosine backbone amine linked to a C18 fatty acid chain. Cer(t18:0/18:0) has the function of regulating apoptosis, cell differentiation, proliferation of smooth muscle cells and inhibition of mitochondrial respiratory chain. It also suppresses the expression of allergic cytokines IL-4, TNF-α, and transcription factors c-Jun and NF-κB in histone-stimulated mouse skin tissue. Formulations containing cer(t18:0/18:0) have been used as skin protectants in cosmetics as they reduce water loss and prevent epidermal dehydration and irritation.

HY-146066

α7 nAchR-JAK2-STAT3 agonist 1	nAChR JAK STAT NO Synthase	Inflammation/Immunology
α7 nAchR-JAK2-STAT3 agonist 1 is a potent α7 nAchR-JAK2-STAT3 agonist, with an IC₅₀ value of 0.32 μM for nitric oxide (NO). α7 nAchR-JAK2-STAT3 agonist 1 effectively suppresses the expression of iNOS, IL-1β, and IL-6 in murine RAW264.7 macrophages. α7 nAchR-JAK2-STAT3 agonist 1 can inhibit LPS-induced NO release, NF-κB activation and cytokine production. α7 nAchR-JAK2-STAT3 can be used for researching sepsis.

HY-145801

XT2	Others	Inflammation/Immunology
XT2 is a potent, orally active, and selective inhibitor of NF-κB-inducing kinase (NIK) with an IC₅₀ of 9.1 nM. XT2 suppresses CCl4-induced upregulation of ALT, a key biomarker of acute liver injury. XT2 also decreases immune cell infiltration into the injured liver tissue. XT2 has the potential for the research of liver inflammatory diseases.

HY-13295

Vinpocetine Ethyl apovincaminate	Sodium Channel IKK Phosphodiesterase (PDE)	Inflammation/Immunology Neurological Disease Cardiovascular Disease Cancer
Vinpocetine (Ethyl apovincaminate) is a derivative of the alkaloid Vincamine that blocks voltage-gated Na⁺ channels. The IC₅₀ value of Vinpocetine on direct IKK inhibition in the cell-free system is 17.17 μM. Vinpocetine is a phosphodiesterase (PDE) inhibitor and inhibits *NF-κB*-dependent inflammatory responses by directly targeting IκB kinase complex (IKK), and has been widely used for the treatment of cerebrovascular disorders.

HY-P2036A

FSL-1 TFA	Toll-like Receptor (TLR) MMP HSV Antibiotic	Infection
FSL-1 TFA, a bacterial-derived toll-like receptor 2/6 (TLR2/6) agonist, enhances resistance to experimental HSV-2 infection. FSL-1 TFA induces MMP-9 production through TLR2 and *NF-κB/AP-1* signaling pathways in monocytic THP-1 cells.

HY-N2908

Atraric acid Methyl atrarate	Androgen Receptor NO Synthase p38 MAPK NF-κB	Cancer Inflammation/Immunology
Atraric acid (Methyl atrarate) is a specific androgen receptor (AR) antagonist with anti-inflammatory and anticancer effects. Atraric acid represses the expression of the endogenous prostate specific antigen gene in both LNCaP and C4-2 cells. Atraric acid can also inhibit the synthesis of NO and cytokine, and suppress the MAPK-NFκB signaling pathway. Atraric acid can be used to research prostate diseases and inflammatory diseases.

HY-N0816

Polyphyllin VI	Apoptosis Pyroptosis	Cancer
Polyphyllin VI, an active saponin, possess anti-cancer activities. Polyphyllin VI induces G2/M cell cycle arrest and triggers apoptosis. Polyphyllin VI induces caspase-1-mediated pyroptosis via the induction of ROS/NF-κB/NLRP3/GSDMD signal axis in non-small cell lung cancer.

HY-N1818

Deoxysappanone B 3-Deoxysappanone B	p38 MAPK	Inflammation/Immunology Neurological Disease
Deoxysappanone B (3-Deoxysappanone B) is a homoisoflavone compound isolated from Caesalpinia sappan L (Lignum Sappan). Deoxysappanone B has anti-neuroinflammatory and neuroprotective effects and inhibits the production of neuroinflammatory mediators by blocking the IκB kinase (IKK)-NF-κB and p38/ERK MAPK pathways. Deoxysappanone B can be used in disease studies of neuritis and inflammation-related neurological damage.

HY-N0492S

α-Lipoic Acid-d5 Thioctic acid-d₅; (±)-α-Lipoic acid-d₅; DL-α-Lipoic acid-d₅	NF-κB HIV Mitochondrial Metabolism Endogenous Metabolite Apoptosis	Cancer Infection Inflammation/Immunology
α-Lipoic Acid-d₅ is the deuterium labeled α-Lipoic Acid. α-Lipoic Acid is an antioxidant, which is an essential cofactor of mitochondrial enzyme complexes. α-Lipoic Acid inhibits NF-κB-dependent HIV-1 LTR activation[1][2][3]. α-Lipoic Acid induces endoplasmic reticulum (ER) stress-mediated apoptosis in hepatoma cells[4].

HY-B1640

Ethacrynic acid Etacrynic acid	Gutathione S-transferase NF-κB Calcium Channel	Cancer Inflammation/Immunology
Ethacrynic acid (Etacrynic acid) is a diuretic. Ethacrynic acid is an inhibitor of glutathione S-transferases (GSTs). Ethacrynic acid is a potent inhibitor of *NF-kB-signaling* pathway, and also modulates leukotriene formation. Ethacrynic acid also inhibits L-type voltage-dependent and store-operated calcium channel, leading to relaxation of airway smooth muscle (ASM) cells. Ethacrynic acid has anti-inflammatory properties that reduces the retinoid-induced ear edema in mice.

HY-B1640A

Ethacrynic acid sodium Etacrynic acid sodium	NF-κB Gutathione S-transferase Calcium Channel	Cancer Inflammation/Immunology
Ethacrynic acid (Etacrynic acid sodium) sodium is a diuretic. Ethacrynic acid sodium is an inhibitor of glutathione S-transferases (GSTs). Ethacrynic acid sodium is a potent inhibitor of *NF-kB-signaling* pathway, and also modulates leukotriene formation. Ethacrynic acid sodium also inhibits L-type voltage-dependent and store-operated calcium channel, leading to relaxation of airway smooth muscle (ASM) cells. Ethacrynic acid sodium has anti-inflammatory properties that reduces the retinoid-induced ear edema in mice.

HY-108538

Ethacrynic acid D5	Gutathione S-transferase NF-κB Calcium Channel	Inflammation/Immunology
Ethacrynic acid D5 is a deuterium labeled Ethacrynic acid. Ethacrynic acid is a diuretic. Ethacrynic acid is an inhibitor of glutathione S-transferases (GSTs). Ethacrynic acid is a potent inhibitor of *NF-kB-signaling* pathway, and also modulates leukotriene formation. Ethacrynic acid also inhibits L-type voltage-dependent and store-operated calcium channel, leading to relaxation of airway smooth muscle (ASM) cells. Ethacrynic acid has anti-inflammatory properties that reduces the retinoid-induced ear edema in mice.

HY-13295S

Vinpocetine-d5	Sodium Channel IKK Phosphodiesterase (PDE)	Inflammation/Immunology Neurological Disease Cardiovascular Disease Cancer
Vinpocetine-d₅ is the deuterium labeled Vinpocetine. Vinpocetine (Ethyl apovincaminate) is a derivative of the alkaloid Vincamine that blocks voltage-gated Na+ channels. The IC50 value of Vinpocetine on direct IKK inhibition in the cell-free system is 17.17 μM. Vinpocetine is a phosphodiesterase (PDE) inhibitor and inhibits NF-κB-dependent inflammatory responses by directly targeting IκB kinase complex (IKK), and has been widely used for the treatment of cerebrovascular disorders[1][2][3].

HY-N6263

EGCG Octaacetate AcEGCG; Peracetylated (-)-epigallocatechin-3-gallate	Bacterial	Cancer Infection Cardiovascular Disease
EGCG Octaacetate (AcEGCG) is a proagent of Green tea epigallocatechin-3-gallate (EGCG). EGCG Octaacetate decreases the proinflammatory mediator levels by down-regulating of PI3K/Akt/NFκB phosphorylation and p65 acetylation. EGCG Octaacetate reduces colitis-driven colon cancer in mice. EGCG octaacetate is the potential antibacterial compound for gram-positive bacteria (GPB) and gram-negative bacteria (GNB).

HY-12383S

Pelubiprofen-13C,d3	Isotope-Labeled Compounds COX	Inflammation/Immunology Neurological Disease
Pelubiprofen-¹³C,d₃ is the ¹³C- and deuterium labeled Pelubiprofen. Pelubiprofen, an orally active and non-steroidal anti-inflammatory drug, is a member of the 2-arylpropionic acid family and has relatively selective effects on COX-2 activity. Pelubiprofen inhibits COX activity and the transforming growth factor-β activated kinase 1-IκB kinase β-NF-κB pathway, and has significant anti-inflammatory and analgesic effects[1].

HY-N0492

α-Lipoic Acid Thioctic acid; (±)-α-Lipoic acid; DL-α-Lipoic acid	NF-κB HIV Mitochondrial Metabolism Endogenous Metabolite Apoptosis	Cancer Infection Inflammation/Immunology
α-Lipoic Acid (Thioctic acid) is an antioxidant, which is an essential cofactor of mitochondrial enzyme complexes. α-Lipoic Acid inhibits *NF-κB*-dependent HIV-1 LTR activation. α-Lipoic Acid induces endoplasmic reticulum (ER) stress-mediated apoptosis in hepatoma cells. α-Lipoic Acid can be used with CPUL1 (HY-151802) to construct the self-assembled nanoaggregate CPUL1-LA NA, which has improved antitumor efficacy than CPUL1.

HY-N6588

3,4,5-Tricaffeoylquinic acid 3,4,5-triCQA	Akt NF-κB	Inflammation/Immunology
3,4,5-Tricaffeoylquinic acid (3,4,5-triCQA) inhibits tumor necrosis factor-α-stimulated production of inflammatory mediators in keratinocytes via suppression of Akt- and NF-κB-pathways. 3,4,5-Tricaffeoylquinic acid induces cell cycle arrest at G0/G1, actin cytoskeleton organization, chromatin remodeling, neuronal differentiation, and bone morphogenetic protein signaling in human neural stem cells. 3,4,5-Tricaffeoylquinic acid has the potential for the research of aging-associated diseases.

HY-N1904

4′-Hydroxywogonin 8-Methoxyapigenin	IKK NF-κB p38 MAPK PI3K Akt Reactive Oxygen Species Interleukin Related TNF Receptor Apoptosis Caspase Bcl-2 Family	Cancer Inflammation/Immunology Cardiovascular Disease
4′-Hydroxywogonin (8-Methoxyapigenin), a flavonoid, could be isolated from a variety of plants including Scutellaria barbata and Verbena littoralis. 4′-Hydroxywogonin has anti-inflammatory activity via TAK1/IKK/NF-κB, MAPKs and PI3/AKT signaling pathways. 4′-Hydroxywogonin inhibits angiogenesis by disrupting PI3K/AKT signaling. 4′-Hydroxywogonin inhibits cell proliferation and induces apoptosis.

HY-N0492A

α-Lipoic Acid sodium Thioctic acid sodium; (±)-α-Lipoic acid sodium; DL-α-Lipoic acid sodium	NF-κB HIV Mitochondrial Metabolism Endogenous Metabolite Apoptosis	Cancer Infection Inflammation/Immunology
α-Lipoic Acid (Thioctic acid) sodium is an antioxidant, which is an essential cofactor of mitochondrial enzyme complexes. α-Lipoic Acid sodium inhibits *NF-κB*-dependent HIV-1 LTR activation. α-Lipoic Acid sodium induces endoplasmic reticulum (ER) stress-mediated apoptosis in hepatoma cells. α-Lipoic Acid sodium can be used with CPUL1 (HY-151802) to construct the self-assembled nanoaggregate CPUL1-LA NA, which has improved antitumor efficacy than CPUL1.

HY-120793

CMC2.24 TRB-N0224	Ras Apoptosis MMP	Cancer Inflammation/Immunology
CMC2.24 (TRB-N0224), an orally active tricarbonylmethane agent, is effective against pancreatic tumor in mice by inhibiting Ras activation and its downstream effector ERK1/2 pathway. CMC2.24 is also a potent inhibitor of zinc-dependent MMPs with IC₅₀s ranging from 2.0-69 μM. CMC2.24 alleviates osteoarthritis progression by restoring cartilage homeostasis and inhibiting chondrocyte apoptosis via the NF-κB/HIF-2α axis.

HY-A0062

Telithromycin HMR3647; RU66647	Bacterial Antibiotic	Infection Inflammation/Immunology
Telithromycin (HMR3647) is a novel ketolide antibiotic that structurally resembles macrolides. Telithromycin belongs to the ketolide family that is characterized by a keto group at position 3 of the macrolide ring and is active against bacteria causing community-acquired pneumonia, acute exacerbation of chronic bronchitis, and acute sinusitis. Telithromycin also has similar immunomodulatory effects as macrolides. Telithromycin can be used for the research of respiratory infections including bronchial asthma.

HY-136446

MYLS22	Others	Cancer Cardiovascular Disease
MYLS22 is a first-in-class and selective optic atrophy 1 (OPA1) inhibitor. MYLS22 can target endothelial OPA1 to curtail tumor growth and inhibits angiogenesis by impinging on NFkB activity and on angiogenic gene expression. MYLS22 can inhibit mitochondrial fusion and exacerbate the mitochondrial damage.

HY-P3229

SN52	NF-κB	Cancer
SN52 is a potent, competitive, and cell-permeable inhibitor of *NF-κB2. SN52 is a variant of the SN50 peptide and inhibits the nuclear translocation of p52-RelB* heterodimers. SN52 has a strong radiosensitization effect on prostate cancer cells. SN52 can be used for cancer research.

HY-106381

Aurothiomalate sodium	PKC	Cancer Inflammation/Immunology
Aurothiomalate sodium is a potent and selective oncogenic PKC_ι signaling inhibitor. Aurothiomalate sodium inhibits tumor cell proliferation and not cell apoptosis. Aurothiomalate sodium is a potent thioredoxin reductase (TrxR) inhibitor. Aurothiomalate sodium, an anti-rheumatoid agent, exhibits potent anti-tumor activity.

Cat. No.	Product Name

HY-L014

NF-κB Signaling Compound Library

672 compounds

Nuclear factor-κB (NF-κB)/Rel proteins include NF-κB2 p52/p100, NF-κB1 p50/p105, c-Rel, RelA/p65, and RelB. These proteins function as dimeric transcription factors that regulate the expression of genes and influence a broad range of biological processes including innate and adaptive immunity, inflammation, stress responses, B-cell development, and lymphoid organogenesis. NF-κB plays a key role in regulating the immune response to infection. In addition, activation of the NF-κB pathway is involved in the pathogenesis of chronic inflammatory diseases, such as asthma, rheumatoid arthritis, and inflammatory bowel disease. Incorrect regulation of NF-κB has been linked to cancer, inflammatory and autoimmune diseases, septic shock, viral infection, and improper immune development.

MCE owns a unique collection of 672 small molecule compounds that can be used in the research of NF-κB signaling pathway or high throughput screening (HTS) related drug discovery.

HY-L037

Antioxidant Compound Library

1240 compounds

Oxidative stress is an imbalance of free radicals and antioxidants in the body, which can lead to cell and tissue damage. Oxidative stress can be responsible for the induction of several diseases, both chronic and degenerative, as well as speeding up body aging process and cause acute pathologies. Antioxidants are a class of compounds able to counteract oxidative stress and mitigate its effects on individuals’ health, gained enormous attention from the biomedical research community. Antioxidants have long been substantial and amenable therapeutic arsenals for multifarious diseases such as AD and cancer.

MCE Antioxidant Compound Library contains 1240 compounds that act as antioxidants for high throughput screening (HTS) and high content screening (HCS). This library is a useful tool for discovery new antioxidants and oxidative stress research.

HY-L090

Transcription Factor-Targeted Library

1082 compounds

Transcription is the essential first step in the conversion of the genetic information in the DNA into protein and the major point at which gene expression is controlled. Transcription of protein-coding genes is accomplished by the multi-subunit enzyme RNA polymerase II and an ensemble of ancillary proteins, called transcription factors (TFs). Transcription factors play an important role in the long-term regulation of cell growth, differentiation and responses to environmental cues. Deregulated transcription factors contribute to the pathogenesis of a plethora of human diseases, ranging from diabetes, inflammatory disorders and cardiovascular disease to many cancers, and thus these proteins hold great therapeutic potential.

MCE offers a unique collection of 1082 compounds with validated transcription factor targets modulating properties. MCE transcription factor-targeted compound library is an effective tool for researching transcription factors as drug targets as well as modulation of TFs for different therapeutic applications.

HY-L124

Anti-Prostate Cancer Compound Library

2033 compounds

Cancer is one of the leading causes of mortality amongst world’s population, in which prostate cancer (PCa) is one of the most encountered malignancies among men. Several molecular mechanisms are involved in prostate cancer development and progression. These include common survival factors in prostate cancer (IGF-1), growth factors (TGF-α, EGF), Wnt, Hedgehog, NF-κB, and mTOR and other signaling pathways. These provide potential therapeutic target in prostate cancer treatment.

MCE offers a unique collection of 2033 compounds with identified and potential anti-prostate cancer activity. MCE Anti-Prostate Cancer Compound Library is a useful tool for anti-prostate cancer drugs screening and other related research.

HY-L103

Anti-Colorectal Cancer Compound Library

1426 compounds

Colorectal cancer (CRC), also known as bowel cancer, colon cancer, or rectal cancer, arises as adenocarcinoma from glandular epithelial cells of the large intestine comprised of the colon and rectum. The majority of cases of CRC are sporadic and result from risk factors, such as a sedentary lifestyle, obesity, processed diets, alcohol consumption and smoking. CRC is also a common preventable cancer.

Studies showed several cellular signaling pathways dysregulated in CRC, leading to the onset of malignant phenotypes. Therefore, it is necessary to analyze the signaling pathways involved in the occurrence and development of colorectal cancer to study the progression and drug treatment of colorectal cancer. Among them, Wnt/β-catenin, p53, TGF-β/SMAD, NF-κB, Notch, VEGF and other target genes and signaling pathways are the focus of research. MCE offers a unique collection of 1426 compounds with identified and potential anti-colorectal cancer activity. MCE anti-colorectal cancer compound library is a useful tool for anti-colorectal cancer drugs screening and other related research.

HY-L074

Anti-Breast Cancer Compound Library

1687 compounds

Breast cancer is the most frequent cancer among women, impacting 2.1 million women each year, and also causes the greatest number of cancer-related deaths among women. Surgery is usually the first type of treatment for breast cancer, which is usually followed by chemotherapy or radiotherapy or, in some cases, hormone or targeted therapies, especially for metastatic breast cancer (MBC).

Breast cancer is a heterogeneous disease, which is categorized into 3 major subtypes based on the presence or absence of molecular markers for estrogen or progesterone receptors and human epidermal growth factor 2 (ERBB2; formerly HER2): hormone receptor positive/ERBB2 negative (70% of patients), ERBB2 positive (15%-20%), and triple-negative (tumors lacking all 3 standard molecular markers; 15%). Different intrinsic subtypes exhibit different tumor behavior with different prognoses, and may require specific targeted therapies to maximize treatment effectiveness. Otherwise, some signaling pathways also play important roles in the development of breast cancer, such as NF-κB Signaling Pathway, TGF-beta Signaling Pathway, PI3K/AKT/mTOR signaling pathway and Notch Signaling Pathway. These signaling pathways offer ideal targets for development of new targeted therapies for breast cancer.

MCE supplies a unique collection of 1687 compounds with identified and potential anti-breast cancer activity. MCE Anti-Breast Cancer Compound Library is a useful tool for anti-breast cancer drugs screening.

Cat. No.	Product Name	Type

HY-W016412

Coenzyme Q0

CoQ0

Biochemical Assay Reagents

Coenzyme Q0 (CoQ0) is a potent, oral active ubiquinone compound can be derived from Antrodia cinnamomea. Coenzyme Q0 induces apoptosis and autophagy, suppresses of HER-2/AKT/mTOR signaling to potentiate the apoptosis and autophagy mechanisms. Coenzyme Q0 regulates NFκB/AP-1 activation and enhances Nrf2 stabilization in attenuation of inflammation and redox imbalance. Coenzyme Q0 has anti-angiogenic activity through downregulation of MMP-9/NF-κB and upregulation of HO-1 signaling.

HY-141582

Ceramide 3

N-Stearoyl phytosphingosine

Biochemical Assay Reagents

C18 Phytoceramide (t18:0/18:0) (Cer(t18:0/18:0)) is a bioactive sphingolipid found in the stratum corneum of Saccharomyces cerevisiae, wheat grain, and mammalian epidermis. Cer(t18:0/18:0) consists of a phytosphingosine backbone amine linked to a C18 fatty acid chain. Cer(t18:0/18:0) has the function of regulating apoptosis, cell differentiation, proliferation of smooth muscle cells and inhibition of mitochondrial respiratory chain. It also suppresses the expression of allergic cytokines IL-4, TNF-α, and transcription factors c-Jun and NF-κB in histone-stimulated mouse skin tissue. Formulations containing cer(t18:0/18:0) have been used as skin protectants in cosmetics as they reduce water loss and prevent epidermal dehydration and irritation.

Cat. No.	Product Name	Target	Research Area

HY-P1832

PTD-p65-P1 Peptide	NF-κB Apoptosis	Cancer Inflammation/Immunology
PTD-p65-P1 Peptide is a potent, selective nuclear transcription factor *NF-κB* inhibitor and derives from the p65 subunit of NF-κB amino acid residues 271-282, which selectively inhibits NF-κB activation induced by various inflammatory stimulation, down-regulate NF-κB-mediated gene expression and up-regulate apoptosis.

HY-P1832A

PTD-p65-P1 Peptide TFA	NF-κB Apoptosis	Cancer Inflammation/Immunology
PTD-p65-P1 Peptide TFA is a potent, selective nuclear transcription factor *NF-κB* inhibitor and derives from the p65 subunit of NF-κB amino acid residues 271-282, which selectively inhibits NF-κB activation induced by various inflammatory stimulation, down-regulate NF-κB-mediated gene expression and up-regulate apoptosis.

HY-P0151

SN50
NF-κB Inflammation/Immunology

SN50 is a cell permeable inhibitor of NF-κB translocation.

HY-P1847

IKKγ NBD Inhibitory Peptide	NF-κB	Cancer
IKKγ NBD Inhibitory Peptide is a highly specific inhibitor *NF-κB* inhibitor. IKKγ NBD Inhibitory Peptide acts by disrupting the interaction between IKKγ/NEMO-binding domain (NBD) with IKKα and IKKβ, thus blocking TNF-α-induced NF-kB activation. IKKγ NBD Inhibitory Peptide could significantly suppresses inflammation and ameliorate the cerebral ischemia-induced neurological deficits.

HY-P1847A

IKKγ NBD Inhibitory Peptide TFA	NF-κB	Inflammation/Immunology
IKKγ NBD Inhibitory Peptide TFA is a highly specific inhibitor *NF-κB* inhibitor. IKKγ NBD Inhibitory Peptide TFA acts by disrupting the interaction between IKKγ/NEMO-binding domain (NBD) with IKKα and IKKβ, thus blocking TNF-α-induced NF-kB activation. IKKγ NBD Inhibitory Peptide TFA could significantly suppresses inflammation and ameliorate the cerebral ischemia-induced neurological deficits.

HY-P1098

Ac2-26	NF-κB	Inflammation/Immunology
Ac2-26, an active N-terminal peptide of annexin A1 (AnxA1), attenuates ischemia-reperfusion-induced acute lung injury. Ac2-26 also decreases AnxA1 protein expression, inhibits the activation of NF-κB and MAPK pathways in the injured lung tissue.

HY-100538A

DTP3 TFA	DNA/RNA Synthesis JNK	Cancer
DTP3 TFA is a potent and selective GADD45β/MKK7 (growth arrest and DNA-damage-inducible β/mitogen-activated protein kinase kinase 7) inhibitor. DTP3 TFA targets an essential, cancer-selective cell-survival module downstream of the NF-κB pathway.

HY-P1098A

Ac2-26 TFA	NF-κB	Inflammation/Immunology
Ac2-26 TFA, an active N-terminal peptide of annexin A1 (AnxA1), attenuates ischemia-reperfusion-induced acute lung injury. Ac2-26 also decreases AnxA1 protein expression, inhibits the activation of NF-κB and MAPK pathways in the injured lung tissue.

HY-P1259

PR-39	Proteasome Bacterial	Inflammation/Immunology
PR-39, a natural proline- and arginine-rich antibacterial peptide, is a noncompetitive, reversible and allosteric proteasome inhibitor. PR-39 reversibly binds to the α7 subunit of the proteasome and blocks degradation of NF-κB inhibitor IκBα by the ubiquitin-proteasome pathway. PR-39 stimulates angiogenesis, inhibits inflammatory responses and significant reduces myocardial infarct size in mice.

HY-P1259A

PR-39 TFA	Proteasome Bacterial	Inflammation/Immunology
PR-39 TFA, a natural proline- and arginine-rich antibacterial peptide, is a noncompetitive, reversible and allosteric proteasome inhibitor. PR-39 TFAreversibly binds to the α7 subunit of the proteasome and blocks degradation of NF-κB inhibitor IκBα by the ubiquitin-proteasome pathway. PR-39 TFA stimulates angiogenesis, inhibits inflammatory responses and significant reduces myocardial infarct size in mice.

HY-P2036A

FSL-1 TFA	Toll-like Receptor (TLR) MMP HSV Antibiotic	Infection
FSL-1 TFA, a bacterial-derived toll-like receptor 2/6 (TLR2/6) agonist, enhances resistance to experimental HSV-2 infection. FSL-1 TFA induces MMP-9 production through TLR2 and *NF-κB/AP-1* signaling pathways in monocytic THP-1 cells.

HY-P3229

SN52	NF-κB	Cancer
SN52 is a potent, competitive, and cell-permeable inhibitor of *NF-κB2. SN52 is a variant of the SN50 peptide and inhibits the nuclear translocation of p52-RelB* heterodimers. SN52 has a strong radiosensitization effect on prostate cancer cells. SN52 can be used for cancer research.

Cat. No.	Product Name	Target	Category

HY-N0277

Aconine Jesaconine	NF-κB	Alkaloids Other Alkaloids Classification of Application Fields Disease Research Fields Cancer Source classification Plants Ranunculaceae Aconitum carmichaeli Debx.
Aconine inhibits receptor activator of nuclear factor (NF)-κB ligand (RANKL)-induced *NF-κB* activation.

HY-N0276

Flaconitine
Acetylaconitine; 3-Acetylaconitine
NF-κB Alkaloids Other Alkaloids Source classification Plants other families

Flaconitine is considered to be a NF-κB inhibitor.

HY-N0274

Caffeic acid phenethyl ester	NF-κB Apoptosis	Phenylpropanoids Phenols Polyphenols Simple Phenylpropanols Inflammation/Immunology Disease Research Fields Cancer Anti-aging Classification of Application Fields Source classification Animals
Caffeic acid phenethyl ester is a *NF-κB* inhibitor.

HY-130994

Aeruginosin 865	NF-κB ADC Cytotoxin	Phenols Monophenols Natural Products Classification of Application Fields Disease Research Fields Inflammation/Immunology Source classification Microorganisms
Aeruginosin 865, isolated from terrestrial cyanobacterium Nostoc sp. Lukešová 30/93, is the first aeruginosin-type peptide containing both a fatty acid and a carbohydrate moiety. Aeruginosin 865 inhibits translocation of *NF-kB* to the nucleus. Aeruginosin 865 has anti-inflammatory effect

HY-N0714A

Berbamine dihydrochloride	NF-κB Autophagy Apoptosis	Isoquinoline Alkaloids Alkaloids Monophenols Phenols Disease Research Fields Cancer Classification of Application Fields Source classification Plants other families
Berbamine dihydrochloride is an inhibitor of *NF-κB* activity with remarkable anti-myeloma efficacy.

HY-N10357

3-Ethylthio withaferin A	Others	Steroids Classification of Application Fields Disease Research Fields Other Diseases Source classification Plants Solanaceae Withania somnifera
3-Ethylthio withaferin A is a derivative of Withaferin A. Withaferin A is a NF-kB inhibitor.

HY-N0441

Neferine (-)-Neferine	NF-κB Autophagy Apoptosis	Alkaloid Dimers Alkaloids Monophenols Phenols Disease Research Fields Cancer Classification of Application Fields Source classification Plants other families
Neferine is a major bisbenzylisoquinline alkaloid. Neferine strongly inhibits *NF-κB* activation.

HY-N3796

Echinulin Echinuline	NF-κB	Alkaloids Indole Alkaloids Classification of Application Fields Disease Research Fields Inflammation/Immunology Source classification Microorganisms
Echinulin (Echinuline) is a cyclic dipeptide carrying a triprenylated indole moiety. Echinulin contributes to the activation of T cell subsets, which leads to *NF-κB* activation.Echinulin exerts its immune roles by the NF-κB pathway.Echinulin has the potential to serve as a immunotherapeutic agent.

HY-N6031

Dendrophenol Moscatilin	NF-κB	Phenols Polyphenols Classification of Application Fields Disease Research Fields Cancer Source classification Plants Orchidaceae Dendrobium chrysanthum Wall. ex Lindl.
Dendrophenol (Moscatilin) acts as a *NF-κB* inhibitor. Antineoplastic activity.

HY-N5048

Galloylpaeoniflorin 6'-O-Galloyl paeoniflorin	NF-κB	Phenols Polyphenols Classification of Application Fields Disease Research Fields Other Diseases Source classification Plants Paeoniaceae Paeonia lactiflora Pall.
Galloylpaeoniflorin is a *NF-κB* inhibitor. And Galloylpaeoniflorin is a inhibitor of DNA cleavage.

HY-N0191

Andrographolide Andrographis	NF-κB SARS-CoV Influenza Virus Autophagy Parasite	Terpenoids Diterpenoids Inflammation/Immunology Infection Disease Research Fields Classification of Application Fields Source classification Plants Acanthaceae Andrographis paniculata (Burm. F.) Nees
Andrographolide is a *NF-κB* inhibitor, which inhibits NF-κB activation through covalent modification of a cysteine residue on p50 in endothelial cells without affecting IκBα degradation or p50/p65 nuclear translocation. Andrographolide has antiviral effects.

HY-119970

Helenalin	NF-κB	Terpenoids Sesquiterpenes Classification of Application Fields Disease Research Fields Inflammation/Immunology Source classification Plants other families
Helenalin is an anti-inflammatory sesquiterpene lactone. Helenalin selectively inhibits transcription factor *NF-κB* by directly targeting p65. Helenalin has alkylating activity, targets the cysteine sulfhydryl groups in the p65 subunit of NF-κB, thereby inhibits its DNA binding.

HY-14592

Tectochrysin Techtochrysin; NSC 80687	NF-κB	Monophenols Phenols Flavones Flavonoids Disease Research Fields Cancer Classification of Application Fields Source classification Plants Zingiberaceae Alpinia oxyphylla Miq.
Tectochrysin (Techtochrysin) is one of the major flavonoids of Alpinia oxyphylla Miquel. Tectochrysin inhibits activity of *NF-κB*.

HY-B0167A

Sodium Salicylate Salicylic acid sodium salt; 2-Hydroxybenzoic acid sodium salt	COX NF-κB Ribosomal S6 Kinase (RSK) Autophagy Apoptosis Endogenous Metabolite	Ketones, Aldehydes, Acids Phenols Inflammation/Immunology Disease Research Fields Cancer Classification of Application Fields Source classification Plants Asclepiadaceae Periploca sepium Bunge
Sodium Salicylate (Salicylic acid sodium salt) inhibits cyclo-oxygenase-2 (COX-2) activity independently of transcription factor (NF-κB) activation. Sodium Salicylate is also a S6K inhibitor.Sodium Salicylate is a *NF-κB* inhibitor that decreases inflammatory gene expression and improves repair in aged muscle.

HY-N0509

Astilbin	Keap1-Nrf2 TNF Receptor NF-κB	Phenols Flavanonols Polyphenols Flavonoids Disease Research Fields Cancer Classification of Application Fields Source classification Plants other families
Astilbin is a flavonoid compound and enhances NRF2 activation. Astilbin also suppresses TNF-α expression and *NF-κB* activation.

HY-116035

Nimbolide	NF-κB CDK Apoptosis	Triterpenes Terpenoids Structural Classification Azadirachta indica A. Juss. Meliaceae Plants Source classification Disease Research Fields Cancer Classification of Application Fields
Nimbolide is a triterpene derived from the leaves and flowers of neem (Azadirachta indica). Nimbolide induces apoptosis through inactivation of *NF-κB. Nimbolide inhibits CDK4/CDK6* kinase activity. Nimbolide suppresses the NF-κB, Wnt, PI3K-Akt, MAPK and JAK-STAT signaling pathways.

HY-N0694

Schisantherin A Gomisin-C; Schizantherin-A; Wuweizi ester-A	NF-κB	Phenylpropanoids Lignans Classification of Application Fields Disease Research Fields Inflammation/Immunology Source classification Plants Schisandraceae Schisandra chinensis (Turcz.) Baill.
Schisantherin A is a dibenzocyclooctadiene lignan. Schisantherin A inhibits *p65-NF-κB* translocation into the nucleus by IκBα degradation.

HY-N10458

Asperbisabolane L	NF-κB	Sesquiterpenes
Asperbisabolane L, a sesquiterpenoid, exerts the anti-inflammatory activity by inhibiting the *NF-κB*-activated pathway. Asperbisabolane L inhibits the translocation of NF-κB from cytoplasm to the nucleus. Asperbisabolane L also inhibits NO production in LPS-activated BV-2 microglia cells.

HY-N1987

Cucurbitacin IIb	Apoptosis	Triterpenes Terpenoids Inflammation/Immunology Disease Research Fields Classification of Application Fields Plants Cucurbitaceae Hemsleya amabilis Diels
Cucurbitacin IIb is an active component isolated from Hemsleya amabilis, induces apoptosis with anti-inflammatory activity. Cucurbitacin IIb inhibits phosphorylation of STAT3, JNK and Erk1/2, enhances the phosphorylation of IκB and NF-κB (p65), blocks nuclear translocation of NF-κB (p65) and decreases mRNA levels of IκBα and TNF-α.

HY-114519

Helenalin acetate	Histone Demethylase NF-κB	Sesquiterpenes Source classification Plants Compositae Arnica longifolia D.C.Eaton
Helenalin acetate, a natural *NF-κB* inhibitor, is a potent C/EBPβ inhibitor. Helenalin acetate has anti-inflammatory and anticancer activities.

HY-N3625

Coronalolic acid Coronalonic acid	NF-κB	Terpenoids Other Terpenoids Classification of Application Fields Disease Research Fields Inflammation/Immunology Source classification Plants Rubiaceae Gardenia jasminoides Ellis
Coronalolic acid, extract from the apical bud of Gardenia sootepenesis Hutch, inhibits TNF-α-induced *NF-κB* activity and NO production.

HY-N4231

Lucyoside B	NF-κB	Terpenoids Triterpenes Classification of Application Fields Disease Research Fields Inflammation/Immunology Source classification Plants Cucurbitaceae Luffa aegyptiaca Miller
Lucyoside B inhibits the production of inflammatory mediators via both *NF-κB* and activator protein-1 pathways in activated macrophages.

HY-119720

Neocryptotanshinone	NF-κB NO Synthase	Quinones Naphthalene Quinones Terpenoids Structural Classification Diterpenoids Labiatae Plants Hemistepta lyrata Source classification Inflammation/Immunology Disease Research Fields Classification of Application Fields
Neocryptotanshinone, a fatty diterpenoids from Salvia Miltiorrhiza, inhibits lipopolysaccharide-induced inflammation by suppression of *NF-κB* and iNOS signaling pathways.

HY-N11494

Dauricumine	NF-κB	Structural Classification Alkaloid Dimers Alkaloids Menispermum dauricum Menispermaceae Plants Source classification
Dauricumine is a chlorinated alkaloid that inhibits NF-κB ligand-induced differentiation of mouse bone marrow-derived macrophages into multinucleated osteoclasts.

HY-N8816

Stipuleanoside R2	NF-κB	Triterpenes Terpenoids Structural Classification Aralia chinensis L. Araliaceae Plants Source classification Inflammation/Immunology Disease Research Fields Classification of Application Fields
Stipuleanoside R2 inhibits *NF-κB* activation stimulated by TNFα in a dose-dependent manner with IC₅₀ value of 4.1 μM.

HY-N10119

Ganoderterpene A	p38 MAPK	Terpenoids Triterpenes Source classification Plants Polyporaceae
Ganoderterpene A attenuates LPS-induced inflammation and apoptosis via suppressing MAPK and TLR-4/NF-κB pathways in BV-2 cells.

HY-N1380

Guaiacol 2-Methoxyphenol	COX NF-κB Endogenous Metabolite	Monophenols Phenols Inflammation/Immunology Disease Research Fields Classification of Application Fields Source classification Plants other families Endogenous metabolite
Guaiacol, a phenolic compound, inhibits LPS-stimulated COX-2 expression and *NF-κB* activation. Anti-inflammatory activity.

HY-N3497

Isochamaejasmin	NF-κB DNA/RNA Synthesis Parasite Apoptosis	Other Flavonoids Structural Classification Flavonoids Thymelaeaceae Plants Stellera chamaejasme Linn.
Isochamaejasmin is a biflavonoid with anti-cancer, antiplasmodial and insecticidal activities. Isochamaejasmin displays a potent *NF-κB* (NF-κB) activation activity. Isochamaejasmin could cause DNA damage and induce apoptosis via the mitochondrial pathway in AW1 cells. Isochamaejasmin also has a moderate antiplasmodial activity (IC₅₀ of 7.3 μM for *P. falciparum*) and relatively low cytotoxicity (CC₅₀ of 29.0 μM).

HY-15122

Sinomenine	NF-κB Opioid Receptor Autophagy Apoptosis	Alkaloids Piperidine Alkaloids Phenols Monophenols Classification of Application Fields Disease Research Fields Inflammation/Immunology Neurological Disease Source classification Plants Menispermaceae Sinomenium acutum(Thunb．)Rehd．Et Wils．
Sinomenine, an alkaloid extracted from Sinomenium acutum, is a blocker of the *NF-κB* activation. Sinomenine also is an activator of μ-opioid receptor.

HY-N0197

Baicalin Baicalein 7-O-β-D-glucuronide	NF-κB Autophagy HIV	Flavones Flavonoids Disease Research Fields Cancer Classification of Application Fields Source classification Plants Labiatae Scutellaria baicalensis Georgi
Baicalin, as a flavonoid glycoside, is an allosteric carnitine palmityl transferase 1 (CPT1) activator. Baicalin reduces the expression of *NF-κB*.

HY-B0167

Salicylic acid 2-Hydroxybenzoic acid	COX Autophagy Mitophagy Apoptosis Endogenous Metabolite	Ketones, Aldehydes, Acids Monophenols Phenols Inflammation/Immunology Disease Research Fields Cancer Anti-aging Classification of Application Fields Source classification Plants other families Endogenous metabolite
Salicylic acid (2-Hydroxybenzoic acid) inhibits cyclo-oxygenase-2 (COX-2) activity independently of transcription factor (NF-κB) activation.

HY-N0629

Maslinic acid Crategolic acid; 2α-Hydroxyoleanolic acid	NF-κB Bacterial HIV Endogenous Metabolite	Triterpenes Terpenoids Disease Research Fields Cancer Classification of Application Fields Source classification Plants other families
Maslinic acid can inhibit the DNA-binding activity of NF-κB p65 and abolish the phosphorylation of IκB-α, which is required for p65 activation.

HY-N1490

14-Deoxy-11,12-didehydroandrographolide 14-dehydro Andrographolide; AP10	NF-κB	Terpenoids Diterpenoids Classification of Application Fields Disease Research Fields Cancer Source classification Plants Acanthaceae Andrographis paniculata (Burm. F.) Nees
14-Deoxy-11,12-didehydroandrographolide is an analogue of Andrographolide. 14-Deoxy-11,12-didehydroandrographolide inhibits *NF-κB* activation.

HY-N0298

Stachydrine	NF-κB Endogenous Metabolite	Pyrrole Alkaloids Alkaloids Disease Research Fields Cancer Classification of Application Fields Source classification Plants Labiatae Lactuca perennis Endogenous metabolite
Stachydrine is a major constituent of Chinese herb leonurus heterophyllus sweet used to promote blood circulation and dispel blood stasis. Stachydrine can inhibit the *NF-κB* signal pathway.

HY-N2083

Handelin	NF-κB	Sesquiterpenes Structural Classification Terpenoids Compositae Chrysanthemum boreale Plants Inflammation/Immunology Disease Research Fields Classification of Application Fields
Handelin is a guaianolide dimer from Chrysanthemum boreale that has potent anti-inflammatory activity by down-regulating *NF-κB* signaling and pro-inflammatory cytokine production.

HY-15122A

Sinomenine hydrochloride Cucoline hydrochloride	NF-κB Opioid Receptor Autophagy Apoptosis	Alkaloids Monophenols Phenols Piperidine Alkaloids Inflammation/Immunology Neurological Disease Disease Research Fields Classification of Application Fields Source classification Plants Menispermaceae Sinomenium acutum(Thunb．)Rehd．Et Wils．
Sinomenine hydrochloride (Cucoline hydrochloride), an alkaloid extracted from Sinomenium acutum, is a blocker of the *NF-κB* activation. Sinomenine also is an activator of μ-opioid receptor.

HY-N0474

Tyrosol	NF-κB Endogenous Metabolite	Structural Classification Monophenols Phenols Inflammation/Immunology Disease Research Fields Anti-aging Classification of Application Fields Source classification Plants Burseraceae Canarium album (Lour.) Rauesch. Endogenous metabolite
Tyrosol is a derivative of phenethyl alcohol. Tyrosol attenuates pro-inflammatory cytokines from cultured astrocytes and *NF-κB* activation. Anti-oxidative and anti-inflammatory effects.

HY-N0436

Engeletin	NF-κB	Phenols Flavanonols Polyphenols Flavonoids Inflammation/Immunology Disease Research Fields Classification of Application Fields Source classification Plants Liliaceae Smilacis Glabrae Rhizoma
Engeletin is a flavanonol glycoside isolated from Smilax glabra Roxb. , inhibits *NF-κB* signaling-pathway activation, and possesses anti-inflammatory, analgesic, diuresis, detumescence, and antibiosis effects.

HY-N6046

Kamebakaurin	NF-κB	Terpenoids Diterpenoids Inflammation/Immunology Disease Research Fields Cancer Classification of Application Fields Plants Labiatae Rabdosia excisa (Maxim.) Hara
Kamebakaurin is a natural compound isolated from Rabdosia excisa. Kamebakaurin is a potent inhibitor of *NF-κB* activation by directly targeting DNA-binding activity of p50.

HY-N2149A

Tomatidine hydrochloride	NF-κB JNK Autophagy Endogenous Metabolite	Steroids Disease Research Fields Classification of Application Fields Cardiovascular Disease Source classification Plants Solanaceae Lycopersicon esculentum Miller
Tomatidine hydrochloride acts as an anti-inflammatory agent by blocking *NF-κB* and JNK signaling. Tomatidine hydrochloride activates autophagy either in mammal cells or C elegans.

HY-N2149

Tomatidine	NF-κB JNK Autophagy Endogenous Metabolite	Alkaloids Steroids Pyridine Alkaloids Inflammation/Immunology Disease Research Fields Anti-aging Classification of Application Fields Cardiovascular Disease Source classification Plants Solanaceae Lycopersicon esculentum Miller
Tomatidine acts as an anti-inflammatory agent by blocking *NF-κB* and JNK signaling. Tomatidine activates autophagy either in mammal cells or C elegans.

HY-15027

5-Aminosalicylic Acid Mesalamine; 5-ASA; Mesalazine	PPAR PAK NF-κB Endogenous Metabolite	Ketones, Aldehydes, Acids Monophenols Phenols Structural Classification Endogenous metabolite Source classification Disease Research Fields Cancer Classification of Application Fields
5-Aminosalicylic acid (Mesalamine) acts as a specific PPARγ agonist and also inhibits p21-activated kinase 1 (PAK1) and *NF-κB*.

HY-125911

Gossypin	NF-κB	Flavonoids Flavonols Phenols Polyphenols Classification of Application Fields Disease Research Fields Cardiovascular Disease Inflammation/Immunology Source classification Plants Malvaceae Abelmoschus manihot (Linn.) Medicus
Gossypin is a flavone isolated from Hibiscus vitifolius and has antioxidant, antiinflammatory, anticancer, anticataract, antidiabetic, and hepatoprotective activities. Gossypin inhibits *NF-κB* and NF-κB-regulated gene expression. Gossypin inhibits RANKL-induced osteoclastogenesis both in mouse primary bone marrow cells and RAW 264.7 cells in vitro.

HY-N4182

Licochalcone E	Akt p38 MAPK Autophagy	Chalcones Flavonoids Inflammation/Immunology Disease Research Fields Classification of Application Fields Source classification Plants Leguminosae Glycyrrhiza uralensis Fisch.
Licochalcone E, a flavonoid compound isolated from Glycyrrhiza uralensis, inhibits NF-κB and AP-1 transcriptional activity through the inhibition of AKT and MAPK activation.

HY-U00450

4-O-Methyl honokiol	PPAR NF-κB	Phenylpropanoids Monophenols Phenols Lignans Inflammation/Immunology Disease Research Fields Cancer Classification of Application Fields Source classification Plants other families Magnoliaceae Magnolia officinalis. Rehd. et Wils.
4-O-Methyl honokiol is a natural neolignan isolated from Magnolia officinalis, acts as a PPARγ agonist, and inhibtis *NF-κB* activity, used for cancer and inflammation research.

HY-N0803

Myrcene β-Myrcene	NF-κB	Terpenoids Other Monoterpenes Classification of Application Fields Disease Research Fields Other Diseases Source classification Plants Pinaceae Pinus sylvestris Linn. var. mongolica Litv.
Myrcene (β-Myrcene), an aromatic volatile compound, suppresses TNFα-induced NF-κB activity. Myrcene has anti-invasive effect.

HY-N0708

Vanillic acid	NF-κB Bacterial Endogenous Metabolite	Ketones, Aldehydes, Acids Monophenols Phenols Inflammation/Immunology Disease Research Fields Classification of Application Fields Source classification Plants Umbelliferae Angelica sinensis (Oliv.) Diels Endogenous metabolite Disease markers Immune System Disorder
Vanillic acid is a flavoring agent found in edible plants and fruits, also found in Angelica sinensis. Vanillic acid inhibits *NF-κB* activation. Anti-inflammatory, antibacterial, and chemopreventive effects.

HY-N6812

Karacoline	NF-κB	Terpenoids Structural Classification Diterpenoids Aconitum carmichaeli Debx. Ranunculaceae Plants Source classification Disease Research Fields Classification of Application Fields Endocrinology
Karacoline, a diterpene alkaloid found in the plant Aconitum kusnezoffii, reduces degradation of the extracellular matrix (ECM) in intervertebral disc degeneration (IDD) via the NF-κB signaling pathway.

HY-122808

(-)-Camphoric acid	mGluR	Ketones, Aldehydes, Acids Classification of Application Fields Disease Research Fields Metabolic Disease Source classification Plants Lauraceae Cinnamomum glanduliferum (Wall.) Nees
(-)-Camphoric acid is the less active enantiomer of Camphoric acid. Camphoric acid stimulates osteoblast differentiation and induces glutamate receptor expression. Camphoric acid also significantly induced the activation of NF-κB and AP-1.

HY-113509

Lipoxin A4 LXA4	Interleukin Related Endogenous Metabolite	Ketones, Aldehydes, Acids Classification of Application Fields Disease Research Fields Inflammation/Immunology Source classification Endogenous metabolite
Lipoxin A4 (LXA4), an endogenous lipoxygenase-derived eicosanoid mediator, has potent dual pro-resolving and anti-inflammatory properties. Lipoxin A4 inhibits proliferation and inflammatory cytokine/chemokine production of human epidermal keratinocytes (NHEKs) associated with the ERK1/2 and NF-kB pathways. Lipoxin A4 inhibits serum amyloid A (SAA)-mediated IL-8 release with an IC₅₀ value of 25.74 nM.

HY-N6673

Okanin	Toll-like Receptor (TLR) NF-κB	Chalcones Phenols Polyphenols Flavonoids Neurological Disease Disease Research Fields Classification of Application Fields Cardiovascular Disease Source classification Plants Compositae Cercis chinensis Bunge
Okanin, effective constituent of the flower tea Coreopsis tinctoria, attenuates LPS-induced microglial activation through inhibition of the *TLR4/NF-κB* signaling pathways.

HY-113556

Sappanone A	NF-κB Keap1-Nrf2	Flavonoids Isoflavones Classification of Application Fields Disease Research Fields Inflammation/Immunology Source classification Plants Leguminosae Caesalpinia sappan L.
Sappanone A is a homoisoflavanone which exhibits anti-inflammatory effects via modulation of Nrf2 and *NF-κB*. Sappanone can attenuate allergic airway inflammation in Ovalbumin-induced asthma.

HY-N1382

Asperuloside	NO Synthase	Terpenoids Iridoids Classification of Application Fields Disease Research Fields Inflammation/Immunology Source classification Plants Rubiaceae Hedyotis diffusa Willd.
Asperuloside is an iridoid isolated from Hedyotis diffusa, with anti-inflammatory activity. Asperuloside inhibits inducible nitric oxide synthase (iNOS), suppresses NF-κB and MAPK signaling pathways.

HY-N0622

Morusin Mulberrochromene	NF-κB STAT Bacterial	Phenols Polyphenols Flavones Flavonoids Inflammation/Immunology Infection Disease Research Fields Classification of Application Fields Source classification Plants other families
Morusin is a prenylated flavonoid isolated from Morus alba Linn. with various biological activities, such as antitumor, antioxidant, and anti-bacteria property. Morusin could inhibit *NF-κB* and STAT3 activity.

HY-N6065

Praeruptorin A	NF-κB	Coumarins Phenylpropanoids Inflammation/Immunology Disease Research Fields Classification of Application Fields Source classification Plants Umbelliferae Peucedanum pracruptorum Dunn
Praeruptorin A is a main bioactive constituent of Peucedanum praeruptorum (also known as Bai-Hua Qian Hu). Praeruptorin A exerts anti-inflammatory effects in vitro through inhibition of *NF-κB* activation.

HY-N0738

Stachydrine hydrochloride	NF-κB Endogenous Metabolite	Pyrrole Alkaloids Structural Classification Alkaloids Disease Research Fields Cancer Classification of Application Fields Source classification Plants Labiatae Lactuca perennis
Stachydrine hydrochloride is the major active constituent of Leonurus artemisia, which is a potential therapy for cardiovascular diseases. Stachydrine can inhibit the *NF-κB* signal pathway. Anti-hypertrophic activities.

HY-126382

Hesperidin methylchalcone	NF-κB	Flavonoids Chalcones Disease Research Fields Inflammation/Immunology Source classification Plants Rutaceae Citrus
Hesperidin methylchalcone (Hesperidin methyl chalcone) inhibits oxidative stress, cytokine production and *NF-κB* activation. Hesperidin methylchalcone inhibits inflammation and pain. Hesperidin methylchalcone exhibits vasoprotective activity.

HY-N2065

Withaferin A	NF-κB Ferroptosis	Steroids Inflammation/Immunology Disease Research Fields Classification of Application Fields Source classification Plants Solanaceae Withania somnifera other families
Withaferin A is a steroidal lactone isolated from Withania somnifera, inhibits *NF-kB* activation and targets vimentin, with potent antiinflammatory and anticancer activities. Withaferin A is an inhibitor of endothelial protein C receptor (EPCR) shedding.

HY-N0208

Kaempferol-3-O-glucorhamnoside	p38 MAPK NF-κB	Flavonols Phenols Polyphenols Flavonoids Inflammation/Immunology Disease Research Fields Classification of Application Fields Source classification Plants Santalaceae Thesium chinense Turcz.
Kaempferol-3-O-glucorhamnoside, a flavonoid derived from plant Thesium chinense Turcz, inhibits inflammatory responses via MAPK and NF-κB pathways in vitro and in vivo.

HY-W001174

2,5-Dihydroxyacetophenone	ERK NF-κB	Phenols Polyphenols Inflammation/Immunology Disease Research Fields Classification of Application Fields Source classification Plants Scrophulariaceae Rehmannia glutinosa (Gaert.) Libosch. ex Fisch. et Mey
2,5-Dihydroxyacetophenone, isolated from Rehmannia glutinosa, inhibits the production of inflammatory mediators in activated macrophages by blocking the ERK1/2 and *NF-κB* signaling pathways.

HY-N1410

Triacetylresveratrol	STAT NF-κB	Stilbenes Classification of Application Fields Disease Research Fields Cancer Source classification Plants Polygonaceae Reynoutria japonica Houtt.
Triacetylresveratrol, an acetylated analog of Resveratrol. Triacetylresveratrol decreases the phosphorylation of STAT3 and *NF-κB* in a dose- and time- dependent manner in PANC-1 and BxPC-3 cells. Anticancer effects.

HY-N0452

Hyperoside	Influenza Virus Fungal NF-κB Apoptosis	Flavonols Phenols Polyphenols Flavonoids Inflammation/Immunology Disease Research Fields Classification of Application Fields Source classification Plants Guttiferae Hypericum monogynum L.
Hyperoside is a *NF-κB* inhibitor, found from Hypericum monogynum. Hyperoside shows anti-tumor, antifungal, anti-inflammatory, anti-viral, and anti-oxidative activities, and can induce apoptosis.

HY-N0907

Ginsenoside Rg6	NF-κB Apoptosis	Terpenoids Triterpenes Classification of Application Fields Disease Research Fields Inflammation/Immunology Source classification Plants Araliaceae Panax ginseng C. A. Meyer
Ginsenoside Rg6 inhibits TNF-α-induced *NF-κB* transcriptional activity with an IC₅₀ of 29.34 μM in HepG2 cells. Ginsenoside Rg6 also exhibits apoptosis-inducing effect.

HY-N0773

Isovitexin Saponaretin; Homovitexin	JNK NF-κB	Structural Classification Flavones Flavonoids Passiflora coerulea Linn. Palmae Passifloraceae Trachycarpus fortunei (Hook.) H. Wendl. Plants Moraceae Cannabis sativa L Inflammation/Immunology Disease Research Fields Classification of Application Fields
Isovitexin is a flavonoid isolated from passion flower, Cannabis and, and the palm, possesses anti-inflammatory and anti-oxidant activities; Isovitexin acts like a JNK1/2 inhibitor and inhibits the activation of *NF-κB*.

HY-32735

Triptolide PG490	NF-κB Apoptosis	Terpenoids Diterpenoids Biological Pesticide Research Disease Research Fields Cancer Anti-aging Agricultural Research Classification of Application Fields Source classification Plants Celastraceae Tripterygium wilfordii Hook. f.
Triptolide is a diterpenoid triepoxide extracted from the root of Tripterygium wilfordii with immunosuppressive, anti-inflammatory, antiproliferative and antitumour effects. Triptolide is a *NF-κB* activation inhibitor.

HY-N1949

Homoplantaginin	TNF Receptor NF-κB	Flavonoids Flavones Phenols Polyphenols Classification of Application Fields Disease Research Fields Inflammation/Immunology Source classification Plants Labiatae Stevia rebaudiana (Bertoni) Bertoni
Homoplantaginin is a flavonoid from a traditional Chinese medicine Salvia plebeia with antiinflammatory and antioxidant properties. Homoplantaginin could inhibit TNF-α and IL-6 mRNA expression, IKKβ and *NF-κB* phosphorylation.

HY-136512

Streptazolin	Antibiotic	Antibiotics Other Antibiotics Classification of Application Fields Disease Research Fields Inflammation/Immunology Source classification Microorganisms
Streptazolin is an antibiotic. Streptazolin increases bacterial killing and elaboration of immunostimulatory cytokines by macrophages in vitro. Streptazolin stimulates the macrophage NF-κB pathway via PI3K signaling.

HY-N0044

Ginsenoside Re Ginsenoside B2; Panaxoside Re; Sanchinoside Re	Amyloid-β NF-κB JNK Endogenous Metabolite	Triterpenes Terpenoids Neurological Disease Disease Research Fields Cancer Classification of Application Fields Source classification Plants Araliaceae Panax ginseng C. A. Meyer Endogenous metabolite
Ginsenoside Re (Ginsenoside B2) is an extract from Panax notoginseng. Ginsenoside Re decreases the β-amyloid protein (Aβ). Ginsenoside Re plays a role in antiinflammation through inhibition of JNK and *NF-κB*.

HY-N0052A

Sanguinarine chloride Sanguinarin chloride; Sanguinarium chloride; Pseudochelerythrine chloride	Apoptosis Autophagy Bacterial Parasite	Structural Classification Alkaloids Pyridine Alkaloids Papaveraceae Sanguinaria canadensis Plants Disease Research Fields Cancer Classification of Application Fields
Sanguinarine (Sanguinarin) chloride, a benzophenanthridine alkaloid derived from the root of Sanguinaria Canadensis, can stimulate apoptosis via activating the production of reactive oxygen species (ROS). Sanguinarine-induced apoptosis is associated with the activation of JNK and NF-κB.

HY-N6826

Asatone	NF-κB	Natural Products Inflammation/Immunology Disease Research Fields Classification of Application Fields Source classification Plants Aristolochiaceae Asarum sieboldii Miq.
Asatone is an active component isolated from Radix et Rhizoma Asari, with anti-inflammatory effect via activation of NF-κB and donwn regulation of p-MAPK (ERK, JNK and p38) pathways.

HY-142100

Licoagrochalcone C	NF-κB	Structural Classification Other Flavonoids Flavonoids Glycyrrhiza glabra Linn. Leguminosae Plants Source classification
Licoagrochalcone C, a flavonoid, reveals efficacious inhibitory activity on *NF-κB* transcription. Licoagrochalcone C shows significant inhibitory activity on LPS (HY-D1056)-induced NO production.

HY-N0052

Sanguinarine Sanguinarin; Sanguinarium; Pseudochelerythrine	Apoptosis Autophagy	Isoquinoline Alkaloids Alkaloids Disease Research Fields Cancer Classification of Application Fields Source classification Plants Papaveraceae Macleaya cordata (Willd.) R. Br.
Sanguinarine (Sanguinarin), a benzophenanthridine alkaloid derived from the root of Sanguinaria Canadensis, can stimulate apoptosis via activating the production of reactive oxygen species (ROS). Sanguinarine-induced apoptosis is associated with the activation of JNK and NF-κB.

HY-N2682A

(E)-Dehydrodiconiferyl alcohol	Carbonic Anhydrase	Phenylpropanoids Lignans Phenols Monophenols Classification of Application Fields Disease Research Fields Cancer Source classification Plants Compositae Glycine soya Cyamopsis tetragonoloba (L.) Taub.
(E)-Dehydrodiconiferyl alcohol behaves as good hCA IX and hCA XII dual inhibitors. And (E)-Dehydrodiconiferyl alcohol suppresses the *NF-κB* nuclear translocation in connective tissue of healing area.

HY-13425

Deguelin (-)-Deguelin; (-)-cis-Deguelin	Akt Autophagy Apoptosis	Isoflavanones Structural Classification Flavonoids Derris trifoliata Lour. Leguminosae Plants Source classification Biological Pesticide Research Disease Research Fields Cancer Agricultural Research Classification of Application Fields
Deguelin, a naturally occurring rotenoid, acts as a chemopreventive agent by blocking multiple pathways like PI3K-Akt, IKK-NF-κB, and MAPK-mTOR-survivin-mediated apoptosis. Deguelin binding to Hsp90 leads to a decreased expression of numerous oncogenic proteins, including MEK1/2, Akt, HIF1α, COX-2, and NF-κB.

HY-N2585

Isodeoxyelephantopin	Reactive Oxygen Species NF-κB Autophagy	Terpenoids Sesquiterpenes Classification of Application Fields Disease Research Fields Cancer Source classification Plants Compositae Amorpha fruticosaL.
Isodeoxyelephantopin is a sesquiterpene lactone isolated from Elephantopus scaber. Isodeoxyelephantopin induces ROS generation, suppresses NF-κB activation. Isodeoxyelephantopin also modulates LncRNA expression and exhibit activities against breast cancer.

HY-N2477

Taraxerol	Apoptosis NF-κB	Triterpenes Terpenoids Inflammation/Immunology Disease Research Fields Classification of Application Fields Source classification Plants Compositae Astragalus oleifolius DC.
Taraxerol is isolated from Taraxacum mongolicum, and has anti-inflammtory and anti-cancer effects. Taraxerol attenuates acute inlammation through inhibition of *NF-κB* signaling pathway. Taraxerol induces cell apoptosis.

HY-N0847

Micheliolide	NF-κB	Terpenoids Other Monoterpenes Classification of Application Fields Disease Research Fields Other Diseases Source classification Plants other families
Micheliolide could effectively attenuate the high glucose-stimulated activation of NF-κB, the degradation of IκBα, and the expression of MCP-1, TGF-β1 and FN in rat mesangial cells (MCs).

HY-N2119

Sciadopitysin	NF-κB	Flavonoids Biflavones Phenols Polyphenols Classification of Application Fields Disease Research Fields Inflammation/Immunology Source classification Plants Ginkgoaceae Ginkgo biloba
Sciadopitysin is a type of biflavonoids in leaves from ginkgo biloba. Sciadopitysi inhibits RANKL-induced osteoclastogenesis and bone loss by inhibiting *NF-κB* activation and reducing the expression of c-Fos and NFATc1.

HY-N0220

Dauricine	NF-κB Apoptosis	Isoquinoline Alkaloids Alkaloids Monophenols Phenols Inflammation/Immunology Disease Research Fields Cancer Classification of Application Fields Source classification Plants other families Menispermaceae Menispermum dauricum
Dauricine, a bisbenzylisoquinoline alkaloid in Menispermum dauricum, possesses anti-inflammatory activity. Dauricine inhibits cell proliferation and invasion, and induces apoptosis by suppressing *NF-κB* activation in a dose- and time-dependent manner in colon cancer.

HY-N0250

Saikosaponin D	STAT NF-κB Estrogen Receptor/ERR Bacterial	Terpenoids Triterpenes Classification of Application Fields Disease Research Fields Infection Inflammation/Immunology Source classification Plants Umbelliferae Ajuga reptans L.
Saikosaponin D is a triterpene saponin isolated from Bupleurum, with anti-inflammatory, anti-bacterial, anti-tumor, and anti-allergic activities; Saikosaponin D inhibits selectin, STAT3 and *NF-kB* and activates estrogen receptor-β.

HY-N0819

Raddeanin A	Apoptosis	Terpenoids Triterpenes Classification of Application Fields Disease Research Fields Cancer Source classification Plants other families
Raddeanin A is a natural triterpenoid saponin component of Anemone raddeana, with anti-cancer activities. Raddeanin A exerts anticancer effect on human osteosarcoma via the ROS/JNK and NF-κB signal pathway.

HY-N0141

Parthenolide (-)-Parthenolide	NF-κB Autophagy Mitophagy Apoptosis	Terpenoids Sesquiterpenes Classification of Application Fields Disease Research Fields Cancer Source classification Plants Compositae Euchresta formosana (Hayata) Ohwi
Parthenolide is a sesquiterpene lactone found in the medicinal herb Feverfew. Parthenolide exhibits anti-inflammatory activity by inhibiting *NF-κB* activation; also inhibits HDAC1 protein without affecting other class I/II HDACs.

HY-N2497

Isoliquiritin apioside	NF-κB MMP p38 MAPK	Flavonoids Chalcones Phenols Polyphenols Classification of Application Fields Disease Research Fields Cancer Source classification Plants other families
Isoliquiritin apioside significantly decreases PMA-induced increases in MMP9 activities and suppresses PMA-induced activation of MAPK and *NF-κB*. Isoliquiritin apioside auppresseses invasiveness and angiogenesis of cancer cells and endothelial cells.

HY-N0290

Mangiferin	NF-κB Keap1-Nrf2 Apoptosis	Phenols Polyphenols Xanthones Classification of Application Fields Disease Research Fields Cancer Source classification Plants Liliaceae Anemarrhena asphodeloides Bunge
Mangiferin is a Nrf2 activator. Mangiferin suppresses nuclear translocation of the *NF-κB* subunits p65 and p50. Mangiferin exhibits antioxidant, antidiabetic, antihyperuricemic, antiviral, anticancer and antiinflammatory activities.

HY-N1098

Velutin	HIF/HIF Prolyl-Hydroxylase	Phenols Polyphenols Flavones Flavonoids Inflammation/Immunology Disease Research Fields Classification of Application Fields Source classification Plants other families Microorganisms
Velutin is an aglycone extracted from Flammulina velutipes, with inhibitory activity against melanin biosynthesis. Velutin reduces osteoclast differentiation and down-regulates HIF-1α through the NF-κB pathway.

HY-N0170

Indole-3-carbinol I3C; 3-Indolemethanol	NF-κB Aryl Hydrocarbon Receptor E1/E2/E3 Enzyme Endogenous Metabolite	Indole Alkaloids Alkaloids Disease Research Fields Cancer Classification of Application Fields Source classification Plants other families Endogenous metabolite
Indole-3-carbinol (I3C) inhibits *NF-κB* activity and also is an Aryl hydrocarbon receptor (AhR) agonist, and an inhibitor of WWP1 (WW domain-containing ubiquitin E3 ligase 1).

HY-N0906

Ginsenoside Rk3	NF-κB	Triterpenes Terpenoids Disease Research Fields Classification of Application Fields Cardiovascular Disease Source classification Plants Araliaceae Panax ginseng C. A. Meyer
Ginsenoside Rk3 is present in the roots Panax ginseng herbs. Ginsenoside Rk3 significantly inhibits TNF-α-induced *NF-κB* transcriptional activity, with an IC₅₀ of 14.24±1.30 μM in HepG2 cells.

HY-N0802

Tenuigenin Senegenin	NF-κB Bacterial	Terpenoids Triterpenes Classification of Application Fields Disease Research Fields Inflammation/Immunology Source classification Plants Polygalaceae Polygala tenuifolia Willd.
Tenuigenin is a major active component isolated from the root of the Chinese herb Polygala tenuifolia. Tenuigenin protects against S.aureus-induced pneumonia by inhibiting *NF-κB* activation. Tenuigenin has anti-inflammatory effect.

HY-N0608

Myrislignan	NF-κB	Phenylpropanoids Simple Phenylpropanols Phenols Monophenols Classification of Application Fields Disease Research Fields Inflammation/Immunology Source classification Plants Myristicaceae Myristica fragrans Houtt.
Myrislignan, a lignan isolated from Myristica fragrans Houtt, possesses anti-inflammatory activities. Myrislignan attenuates LPS-induced inflammation reaction in murine macrophage cells through inhibition of NF-kB signalling pathway activation.

HY-N3188

Niloticin	Akt NF-κB	Terpenoids Triterpenes Source classification Plants
Niloticin, tetracyclic triterpenoid compound, is a osteoclastogenesis inhibitor. Niloticin shows anti-viral, antioxidative, and mosquitocidal activities. Niloticin inhibits osteoclastogenesis by blocking RANKL-RANK interaction and suppressing the AKT, MAPK, and *NF-κB* signaling pathways.

HY-N1404

Sodium aescinate	NF-κB	Terpenoids Triterpenes Classification of Application Fields Disease Research Fields Inflammation/Immunology Source classification Plants Hippocastanaceae Aesculus hippocastanum
Sodium aescinate is a triterpene saponin derived from Aesculus hippocastanum seeds, with anti-inflammatory and antioxidant activities. Sodium aescinate inhibits hepatocellular carcinoma growth by targeting CARMA3/NF-κB pathway.

HY-N0316

Mollugin	NF-κB Reactive Oxygen Species Apoptosis VEGFR c-Myc	Terpenoids Sesquiterpenes Phenols Monophenols Classification of Application Fields Disease Research Fields Cancer Source classification Plants Rubiaceae Rubia cordifolia L.
Mollugin is an orally active and potent *NF-κB* inhibitor. Mollugin induces S-phase arrest of HepG2 cells, and increased intracellular reactive oxygen species (ROS) levels. Mollugin induces DNA damage in HepG2 cells, as well as an increase in the expression of p-H2AX. Mollugin shows anti-cancer effect by inhibiting TNF-α-induced NF-κB activation. Mollugin enhances the osteogenic action of BMP-2 (bone morphogenetic protein 2) via the p38-Smad signaling pathway.

HY-W011474

Geranylgeraniol	NF-κB	Natural Products Microorganisms
Geranylgeraniol is an orally acitve vitamin K₂ sub-type, an intermediate of the mevalonate pathway. Geranylgeraniol targets *NF-kB* signaling pathway and could alleviate LPS-induced microglial inflammation in animal model.

HY-122521

Sootepin D	NF-κB	Triterpenes Terpenoids Structural Classification Gardenia jasminoides Ellis Gardenia sootepensis hutchins. Rubiaceae Plants Source classification Inflammation/Immunology Disease Research Fields Classification of Application Fields
Sootepin D (compound 6), a triterpene from the apical bud of Gardenia sootepensis, inhibits TNF-α-induced *NF-κB* activity with an IC₅₀ of 8.3μM. Sootepin D has anti-inflammatory activity.

HY-N0375

18α-Glycyrrhetinic acid	Proteasome NF-κB Apoptosis	Terpenoids Triterpenes Classification of Application Fields Disease Research Fields Inflammation/Immunology Neurological Disease Source classification Plants Leguminosae Glycyrrhiza uralensis Fisch.
18α-Glycyrrhetinic acid, a diet-derived compound, is an inhibitor of *NF-kB* and an activator of proteasome, which serves as pro-longevity and anti-aggregation factor in a multicellular organism. 18α-Glycyrrhetinic acid induces apoptosis.

HY-N2117

Isoginkgetin	MMP Akt NF-κB Proteasome Apoptosis Autophagy	Flavonoids Biflavones Phenols Polyphenols Classification of Application Fields Disease Research Fields Cancer Source classification Plants Ginkgoaceae Ginkgo biloba
Isoginkgetin is a pre-mRNA splicing inhibitor inhibitor. Isoginkgetin also inhibits activities of both Akt, *NF-κB* and MMP-9. Isoginkgetin inhibits the activity of the 20S proteasome, induces apoptosis and activates autophagy.

HY-N0001

(-)-Epicatechin (-)-Epicatechol; Epicatechin; epi-Catechin	COX Ferroptosis Endogenous Metabolite	Flavanols Phenols Polyphenols Flavonoids Inflammation/Immunology Disease Research Fields Cancer Anti-aging Classification of Application Fields Source classification Plants Theaceae Camellia sinensis (L.) O. Ktze. Endogenous metabolite
(-)-Epicatechin inhibits cyclooxygenase-1 (COX-1) with an IC₅₀ of 3.2 μM. (-)-Epicatechin inhibits the IL-1β-induced expression of iNOS by blocking the nuclear localization of the p65 subunit of NF-κB.

HY-N1333

Rubioncolin C	NF-κB	Quinones Naphthalene Quinones Phenols Monophenols Classification of Application Fields Disease Research Fields Cancer Source classification Plants Rubiaceae Rubia podantha
Rubioncolin C exerts anti-tumor activity by inducing apoptotic and autophagic Cell Death and inhibiting the *NF-κB* and Akt/mTOR/P70S6K Pathway in Human Cancer Cells.

HY-119931

2-Hydroxychalcone	Bcl-2 Family Apoptosis NF-κB Parasite	Chalcones Monophenols Phenols Structural Classification Flavonoids Endogenous metabolite Source classification Metabolic Disease Disease Research Fields Classification of Application Fields
2-hydroxychalcone, a natural flavonoid, is a potent antioxidant, inhibiting lipid peroxidation. 2-Hydroxychalcone induces apoptosis by Bcl-2 downregulation. 2-Hydroxychalcone inhibits the activation of NF-kB.

HY-N0589

Dehydrodiisoeugenol	NF-κB COX Bacterial	Phenylpropanoids Monophenols Phenols Simple Phenylpropanols Inflammation/Immunology Disease Research Fields Classification of Application Fields Source classification Plants Myristicaceae Myristica fragrans Houtt.
Dehydrodiisoeugenol is isolated from Myristica fragrans Houtt, shows anti-inflammatory and anti-bacterial actions. Dehydrodiisoeugenol inhibits LPS- stimulated *NF-κB* activation and cyclooxygenase (COX)-2 gene expression in murine macrophages.

HY-N6893

Ergolide	NF-κB	Ketones, Aldehydes, Acids Inflammation/Immunology Disease Research Fields Classification of Application Fields Source classification Plants Compositae Piptanthus nepalensis (Hook.) D. Don Phyllodium pulchellum (L.) Desv.
Ergolide is a sesquiterpene lactone isolated from the dried flowers of Inula Britannica. Ergolide inhibits inducible nitric oxide synthase and cyclo-oxygenase-2 expression in RAW 264.7 macrophages through the inactivation of *NF-κB*.

HY-N0039

Ginsenoside Rb1 Gypenoside III	Na+/K+ ATPase IRAK NF-κB Autophagy Mitophagy HSV	Triterpenes Terpenoids Disease Research Fields Cancer Classification of Application Fields Source classification Plants Araliaceae Panax ginseng C. A. Meyer
Ginsenoside Rb1, a main constituent of the root of Panax ginseng, inhibits Na⁺, K⁺-ATPase activity with an IC₅₀ of 6.3±1.0 μM. Ginsenoside also inhibits IRAK-1 activation and phosphorylation of NF-κB p65 .

HY-N0499

Cyanidin Chloride IdB 1027	RANKL/RANK	Flavonoids Anthocyans Phenols Polyphenols Classification of Application Fields Disease Research Fields Cancer Anti-aging Source classification Plants other families
Cyanidin Chloride (IdB 1027), a subclass of anthocyanin, displays antioxidant and anti-carcinogenesis properties. Cyanidin Chloride (IdB 1027) inhibits osteoclast formation, hydroxyapatite resorption, and receptor activator of NF-κB ligand (RANKL)-induced osteoclast marker gene expression.

HY-N4187

Licochalcone D	NF-κB Apoptosis Reactive Oxygen Species	Chalcones Phenols Polyphenols Flavonoids Inflammation/Immunology Metabolic Disease Disease Research Fields Classification of Application Fields Source classification Plants Leguminosae Glycyrrhiza uralensis Fisch.
Licochalcone D, a flavonoid compound mainly existing in the root of Glycyrrhiza uralensis, is a potent and orally active inhibitor of *NF-kappaB (NF-κB) p65*. Licochalcone D possesses antioxidant, anti-inflammatory, anti-cancer properties.

HY-N10009

Cudraflavone B	NF-κB TNF Receptor COX ERK p38 MAPK Sirtuin	Structural Classification Phenols Polyphenols Brosimopsis oblongifolia Plants Source classification Moraceae
Cudraflavone B is a prenylated flavonoid with anti-inflammatory and anti-tumor properties. Cudraflavone B is also a dual inhibitor of COX-1 and COX-2. Cudraflavone B blocks the translocation of nuclear factor κB (NF-κB) from the cytoplasm to the nucleus in macrophages. Thus, Cudraflavone B inhibits tumor necrosis factor α (TNFα) gene expression and secretion. Cudraflavone B also triggers the mitochondrial apoptotic pathway, activates NF-κB, the MAPK p38, and ERK, and induced the expression of SIRT1. Thus Cudraflavone B inhibits the growth of human oral squamous cell carcinoma cells.

HY-113919

Nothofagin	Calcium Channel	Flavonoids Dihydrochalcones Phenols Polyphenols Classification of Application Fields Disease Research Fields Inflammation/Immunology Source classification Plants other families
Nothofagin, a dihydrochalcone, is isolated from rooibos (Aspalathus linearis). Nothofagin downregulates NF-κB translocation through blocking calcium influx. Nothofagin has antioxidant activity and ameliorates various inflammatory responses such as the septic response and vascular inflammation.

HY-N0608A

(Rac)-Myrislignan	NF-κB	Phenols Monophenols Classification of Application Fields Disease Research Fields Inflammation/Immunology Source classification Plants Myristicaceae Myristica fragrans Houtt.
(Rac)-Myrislignan is the racemate of Myrislignan. Myrislignan, a lignan isolated from Myristica fragrans Houtt, possesses anti-inflammatory activities. Myrislignan attenuates LPS-induced inflammation reaction in murine macrophage cells through inhibition of NF-kB signalling pathway activation.

HY-N0896

Inulicin 1-O-Acetylbritannilactone	NF-κB COX	Sesquiterpenes Terpenoids Inflammation/Immunology Disease Research Fields Classification of Application Fields Source classification Plants Compositae Phyllodium pulchellum (L.) Desv.
Inulicin (1-O-Acetylbritannilactone) is an active compound that inhibits VEGF-mediated activation of Src and FAK. Inulicin (1-O-Acetylbritannilactone) inhibits LPS-induced PGE₂ production and COX-2 expression, and *NF-κB* activation and translocation.

HY-N0045

Ginsenoside Rg1 Panaxoside A; Panaxoside Rg1	Amyloid-β NF-κB Apoptosis	Triterpenes Terpenoids Neurological Disease Disease Research Fields Cancer Anti-aging Classification of Application Fields Source classification Plants Araliaceae Panax ginseng C. A. Meyer
Ginsenoside Rg1 is one of the major active components of Panax ginseng. Ginsenoside Rg1 ameliorates the impaired cognitive function, displays promising effects by reducing cerebral Aβ levels. Ginsenoside Rg1 also reduces *NF-κB* nuclear translocation.

HY-N8085

Icariside F2	NF-κB	Natural Products Classification of Application Fields Disease Research Fields Inflammation/Immunology Source classification Plants Umbelliferae Ligusticum chuanxiong Hort.
Icariside F2 is a potent *NF-κB* inhibitor with an IC₅₀ value of 16.25 μM. Icariside F2 is an aromatic glycoside isolated from the leaves of E. ulmoides Oliver. Icariside F2 has anti-inflammatory activity.

HY-N0222

Avicularin	COX NF-κB PPAR ERK GLUT Apoptosis	Flavonoids Flavonols Phenols Polyphenols Classification of Application Fields Disease Research Fields Inflammation/Immunology Source classification Plants Lauraceae Lindera aggregata (Sims) Kosterm.
Avicularin is an orally active flavonoid. Avicularin inhibits NF-κB (p65), COX-2 and PPAR-γ activities. Avicularin has anti-inflammatory, anti-infectious anti-allergic, anti-oxidant, hepatoprotective, and anti-tumor activities.

HY-N10358

3-(2-Hydroxyethyl) thio withaferin A	NF-κB	Steroids Classification of Application Fields Disease Research Fields Other Diseases Source classification Plants Solanaceae Withania somnifera
3-(2-Hydroxyethyl) thio withaferin A is a Withaferin A derivative. Withaferin A, a steroidal lactone, inhibits NF-kB activation and targets vimentin, with potent antiinflammatory and anticancer activities. Withaferin A is an inhibitor of endothelial protein C receptor (EPCR) shedding.

HY-N0758

Barlerin 8-O-Acetyl shanzhiside methyl ester	NF-κB	Iridoids Terpenoids Inflammation/Immunology Disease Research Fields Classification of Application Fields Source classification Plants Labiatae Helenium radiatum (Less.) Bierner
Barlerin (8-O-Acetyl shanzhiside methyl ester) is an iridoid glucoside isolated from the leaves of Lamiophlomis rotata Kudo, a Chinese folk medicinal plant in Xi-zang. Barlerin (8-O-Acetyl shanzhiside methyl ester) could inhibt *NF-κB*.

HY-N0029

Forsythoside B	TNF Receptor NF-κB	Phenylpropanoids Phenols Polyphenols Simple Phenylpropanols Inflammation/Immunology Disease Research Fields Classification of Application Fields Source classification Plants Oleaceae Forsythia suspensa (Thunb.) Vahl
Forsythoside B is a phenylethanoid glycoside isolated from Forsythia suspensa (Thunb.) Vahl, a Chinese folk medicinal plant for treating inflammatory diseases and promoting blood circulation. Forsythoside B could inhibit TNF-alpha, IL-6, IκB and modulate *NF-κB*.

HY-N7980

Rubipodanone A	NF-κB	Quinones Naphthalene Quinones Classification of Application Fields Disease Research Fields Cancer Source classification Plants Rubiaceae Rubia podantha
Rubipodanone A, a naphthohydroquinone dimer, shows cytotoxicity against A549, BEL-7402, HeLa, HepG2, SGC-7901 and U251 cells. Rubipodanone A also shows obvious activating effect at 20 and 40 μM for NF-κB.

HY-122961

Dehydromiltirone 1,2-Didehydromiltirone	NF-κB p38 MAPK	Terpenoids Diterpenoids Plants Labiatae Hemistepta lyrata
Dehydromiltirone (1,2-Didehydromiltirone) is a diterpenoid quinone with an anti-inflammatory effect. Dehydromiltirone prevents liver injury by modifying the MAPK and *NF-κB* signaling pathways, reducing neuroinflammatory responses, and inhibiting platelet aggregation. Dehydromiltirone can be used for osteoporosis research.

HY-114335

Triphala	NF-κB Fungal	Structural Classification Natural Products Combretaceae Terminalia chebula Retz. Plants Source classification Inflammation/Immunology Infection Disease Research Fields Classification of Application Fields
Triphala, an Ayurvedic polyherbal formulation comprising of equiproportional fruit parts of Terminalia chebula, Terminalia bellerica, and Phyllanthus emblica. Triphala inhibits *NF-κB* activation. Triphala exerts antifungal action. Anti-adipogenic, anti-inflammatory, and anti-neoplastic activities.

HY-N0119

Naringin Dihydrochalcone Naringin DC	NF-κB	Flavonoids Dihydrochalcones Phenols Polyphenols Classification of Application Fields Disease Research Fields Cancer Food Research Sweeteners Source classification Plants other families
Naringin Dihydrochalcone is an artificial sweetener derived from naringin. Naringin is a major flavanone glycoside obtained from tomatoes, grapefruits, and many other citrus fruits. Naringin exhibits biological properties such as antioxidant, anti-inflammatory, and antiapoptotic activities. Naringin suppresses *NF-κB* signaling pathway.

HY-N2101

Benzoyloxypaeoniflorin	Tyrosinase NF-κB	Monophenols Terpenoids Phenols Other Monoterpenes Inflammation/Immunology Disease Research Fields Classification of Application Fields Source classification Plants Paeoniaceae Paeonia lactiflora Pall.
Benzoyloxypaeoniflorin, isolated from the root of Paeonia suffruticosa, is a tyrosinase inhibitor against mushroom tyrosinase with IC₅₀ of 0.453 mM. Benzoyloxypaeoniflorin is *NF-κB* Inhibitor and contributes to improving blood circulation through its inhibitory effect on both platelet aggregation and blood coagulation.

HY-N10175

Berkeleyacetal C	Fungal Endogenous Metabolite	Terpenoids Other Terpenoids Classification of Application Fields Disease Research Fields Inflammation/Immunology Source classification Microorganisms
Berkeleyacetal C, a meroterpenoid compound, shows favorable activity of inhibiting nitrogen oxide (NO) production of macrophages stimulated by lipopolysaccharide (LPS). Berkeleyacetal C exerts anti-inflammatory effects via inhibiting NF-κB, ERK1/2 and IRF3 signaling pathways.

HY-N4327

Eurycomalactone	NF-κB Apoptosis Akt Bcl-2 Family	Terpenoids Structural Classification Diterpenoids other families Plants Source classification Inflammation/Immunology Disease Research Fields Classification of Application Fields
Eurycomalactone is an active quassinoid could be isolated from Eurycoma longifolia Jack. Eurycomalactone is a potent *NF-κB* inhibitor with an IC₅₀ value of 0.5 μM. Eurycomalactone inhibits protein synthesis and depletes cyclin D1. Eurycomalactone enhances radiosensitivity through arrest cell cycle at G2/M phase and delayed DNA double-strand break repair. Eurycomalactone inhibits the activation of AKT/NF‑κB signaling, induces apoptosis and enhances chemosensitivity to Cisplatin (HY-17394).

HY-N10768

1-Dehydro-[10]-gingerdione	IKK NF-κB	Structural Classification Monophenols Phenols Plants Source classification Zingiberaceae
1-Dehydro-[10]-gingerdione directly inhibits IKKβ activity by targeting the activation loop of IKKβ, thus disrupting IKKβ-catalysed IκBα phosphorylation in macrophages stimulated with agonists. 1-Dehydro-[10]-gingerdione inhibits LPS (HY-D1056)-induced *NF-κB* transcriptional activity. 1-Dehydro-[10]-gingerdione has the potential for NF-κB-associated inflammation and autoimmune disorders research.

HY-N0908

Ginsenoside Rg5	IGF-1R NF-κB COX	Terpenoids Triterpenes Classification of Application Fields Disease Research Fields Cardiovascular Disease Endocrinology Inflammation/Immunology Source classification Plants Araliaceae Panax ginseng C. A. Meyer
Ginsenoside Rg5 is the main component of Red ginseng. Ginsenoside blocks binding of IGF-1 to its receptor with an IC₅₀ of ~90 nM. Ginsenoside Rg5 also inhibits the mRNA expression of COX-2 via suppression of the DNA binding activities of NF-κB p65.

HY-N0592A

Demethyleneberberine chloride	NF-κB AMPK	Structural Classification Alkaloids Other Alkaloids Phenols Polyphenols Rutaceae Phellodendron amurense Rupr. Plants Source classification
Demethyleneberberine chloride is a natural mitochondria-targeted antioxidant. Demethyleneberberine chloride alleviates mice colitis and inhibits the inflammatory responses by inhibiting *NF-κB* pathway and regulating the balance of Th cells. Demethyleneberberine chloride could serve as a AMPK activator for treating non-alcoholic fatty liver disease (NAFLD).

HY-W041489

Chelidonic acid	NF-κB Caspase	Ketones, Aldehydes, Acids Disease Research Fields Cancer Classification of Application Fields Source classification Plants Papaveraceae Chelidonium majus
Chelidonic acid is a component of Chelidonium majus L., used as an antimicrobial. Chelidonic acid also shows anti-inflammatory activity. Chelidonic acid has potential to inhibit IL-6 production by blocking *NF-κB* and caspase-1. Chelidonic acid is a glutamate decarboxylase inhibitor, with a K_i of 1.2 μM.

HY-N1956

Rubiadin-1-methyl ether	NF-κB	Quinones Anthraquinones Structural Classification Monophenols Phenols Metabolic Disease Disease Research Fields Classification of Application Fields Source classification Plants Rubiaceae Rubia cordifolia L.
Rubiadin-1-methyl ether is a natural anthraquinone isolated from Morinda officinalis How, and inhibits osteoclastic bone resorption via inhibition on the phosphorylation of NF-κB p65 and the degradation of IκBα as well as decrease in the nuclear translocation of p65.

HY-N2819

Adenanthin	NF-κB	Structural Classification Terpenoids Diterpenoids Labiatae Isodon adenanthus (Diels) Kudo Plants Source classification
Adenanthin is an inhibitor of thiol-dependent antioxidant enzymes, targeting to Prx 1 and Prx 2. Adenanthin impairs human natural killer (NK) cells effector functions, and killing hepatocellular carcinoma cells. Adenanthin inhibits *NF-κB* signaling and lipogenesis and the development of obesity by regulating ROS.

HY-N0592

Demethyleneberberine	NF-κB AMPK	Other Phenylpropanoids Phenylpropanoids Phenols Polyphenols Inflammation/Immunology Disease Research Fields Classification of Application Fields Source classification Plants Rutaceae Phellodendron amurense Rupr.
Demethyleneberberine is a natural mitochondria-targeted antioxidant. Demethyleneberberine alleviates mice colitis and inhibits the inflammatory responses by inhibiting *NF-κB* pathway and regulating the balance of Th cells. Demethyleneberberine could serve as a AMPK activator for treating non-alcoholic fatty liver disease (NAFLD).

HY-N2491

Deoxyelephantopin	NF-κB	Terpenoids Sesquiterpenes Classification of Application Fields Disease Research Fields Cancer Source classification Plants Compositae Amorpha fruticosaL.
Deoxyelephantopin, a natural bioactive sesquiterpene lactone from Elephantopus scaber, has shown promising anticancer effects against a broad spectrum of cancers. Deoxyelephantopin inhibits *NF-κB, MAPK, PI3K/Akt, and β-catenin* signaling.

HY-N3552

Catalposide	NF-κB	Terpenoids Other Terpenoids Phenols Monophenols Classification of Application Fields Disease Research Fields Inflammation/Immunology Source classification Plants Bignoniaceae Catalpa ovata G. Don
Catalposide, an iridoid glycoside that could be isolated from Catalpa ovate G. Don (Bignoniaceae), inhibits TNF-α, IL-1β, and IL-6 productions and NF-κB (p65) activation in lipopolysaccharide-activated RAW 264.7 macrophages.

HY-N6636

Valencene	NF-κB	Sesquiterpenes Terpenoids Inflammation/Immunology Disease Research Fields Classification of Application Fields Source classification Plants Cyperaceae Cyperus rotundus
Valencene is a sesquiterpene isolated from Cyperus rotundus, possesses antiallergic, antimelanogenesis, anti-infammatory, and antioxidant activitivies. Valencene inhibits the exaggerated expression of Th2 chemokines and proinflammatory chemokines through blockade of the *NF-κB* pathway. Valencene is used to flavor foods and drinks.

HY-N6857

Armepavine	NF-κB	Isoquinoline Alkaloids Alkaloids Monophenols Phenols Inflammation/Immunology Disease Research Fields Classification of Application Fields Source classification Plants Nymphaeaceae Nelumbo nucifera Gaertn. other families
Armepavine, an active compound from Nelumbo nucifera, exerts not only anti-inflammatory effects on human peripheral blood mononuclear cells, but also immunosuppressive effects on T lymphocytes and on lupus nephritic mice. Armepavine inhibits TNF-α-induced MAPK and NF-κB signaling cascades.

HY-N1193

Sulfuretin	NF-κB	Phenols Polyphenols Classification of Application Fields Disease Research Fields Inflammation/Immunology Source classification Plants Anacardiaceae Toxicodendron vernicifluum (Stokes) F. A. Barkl.
Sulfuretin inhibits the inflammatory response by suppressing the *NF-κB* pathway. Sulfuretin can be used for the research of allergic airway inflammation. Sulfuretin reduces oxidative stress, platelet aggregation, and mutagenesis. Sulfuretin is a competitive and potent inhibitor of monophenolase and diphenolase activities with the IC₅₀ of 13.64 μM.

HY-117616

Laurotetanine (+)-Laurotetanine	NF-κB	Isoquinoline Alkaloids Alkaloids Structural Classification Lauraceae Plants Source classification Lindera aggregata (Sims) Kosterm.
Laurotetanine ((+)-Laurotetanine) is an potent and orally active isoquinoline alkaloid and could be extracted from the roots of Litsea cubeba (Lour.) Pers. Laurotetanine exerts an anti-asthmatic effect by inhibition of IgE, histamine, and inflammatory reactions via down-regulating MUC5AC and *NF-κB* signaling pathways.

HY-W018772

D-Ribose(mixture of isomers)	Endogenous Metabolite	Saccharides Structural Classification Endogenous metabolite Source classification Disease Research Fields Cancer Classification of Application Fields
D-Ribose(mixture of isomers) is an energy enhancer, and acts as a sugar moiety of ATP, and widely used as a metabolic therapy supplement for chronic fatigue syndrome or cardiac energy metabolism. D-Ribose(mixture of isomers) is active in protein glycation, induces NF-κB inflammation in a RAGE-dependent manner.

HY-N1196

Suberosin	NF-κB	Phenylpropanoids Coumarins Classification of Application Fields Disease Research Fields Inflammation/Immunology Source classification Plants Umbelliferae Heracleum candicans Wall．Ex DC．
Suberosin, isolated from Plumbago zeylanica, exhibits anti-inflammatory and anticoagulant activity. Suberosin suppresses PHA-induced PBMC proliferation and arrested cell cycle progression from the G1 transition to the S phase through the modulation of the transcription factors NF-AT and *NF-κB*.

HY-N2350

Cynaropicrin	MMP NF-κB TNF Receptor	Phenols Disease Research Fields Cancer Classification of Application Fields Source classification Plants Compositae Saussurea costus (Falc.) Lipsch.
Cynaropicrin is a sesquiterpene lactone which can inhibit tumor necrosis factor (TNF-α) release with IC₅₀s of 8.24 and 3.18 μM for murine and human macrophage cells, respectively. Cynaropicrin also inhibits the increase of cartilage degradation factor (MMP13) and suppresses *NF-κB* signaling.

HY-N1346

Robinin	Toll-like Receptor (TLR)	Structural Classification Flavones Flavonoids Leguminosae Vigna unguiculata Plants Inflammation/Immunology Disease Research Fields Classification of Application Fields
Robinin is present in flavonoid fraction of Vigna unguiculata leaf. Robinin inhibits upregulated expression of TLR2 and TLR4. Robinin ameliorates oxidized low density lipoprotein (Ox-LDL) induced inflammatory insult through TLR4/NF-κB pathway.

HY-N0279

Cardamonin Cardamomin; Alpinetin chalcone	NF-κB STAT Wnt β-catenin Bcl-2 Family Apoptosis	Chalcones Phenols Polyphenols Structural Classification Flavonoids Boesenbergia rotunda Plants Source classification Zingiberaceae Disease Research Fields Cancer Classification of Application Fields
Cardamonin can be found from cardamom, and target various signaling molecules, transcriptional factors, cytokines and enzymes. Cardamonin can inhibit mTOR, *NF-κB, Akt, STAT3, Wnt/β-catenin* and COX-2. Cardamonin shows anticancer, anti-inflammatory, antimicrobial and antidiabetic activities.

HY-N0722

Neochlorogenic acid trans-5-O-Caffeoylquinic acid	NF-κB Interleukin Related TNF Receptor COX	Phenylpropanoids Phenols Polyphenols Simple Phenylpropanols Disease Research Fields Cancer Classification of Application Fields Source classification Plants Caprifoliaceae Lonicera japonica Thunb.
Neochlorogenic acid is a natural polyphenolic compound found in dried fruits and other plants. Neochlorogenic acid inhibits the production of TNF-α and IL-1β. Neochlorogenic acid suppresses iNOS and COX-2 protein expression. Neochlorogenic acid also inhibits phosphorylated NF-κB p65 and p38 MAPK activation.

HY-N0569

Madecassic acid	NO Synthase COX TNF Receptor Interleukin Related	Triterpenes Terpenoids Inflammation/Immunology Disease Research Fields Classification of Application Fields Source classification Plants Umbelliferae Centella asiatica
Madecassic acid is isolated from Centella asiatica (Umbelliferae). Madecassic acid has anti-inflammatory properties caused by iNOS, COX-2, TNF-alpha, IL-1beta, and IL-6 inhibition via the downregulation of *NF-κB* activation in RAW 264.7 macrophage cells.

HY-N1356

Reticuline	JAK STAT NF-κB Endogenous Metabolite	Isoquinoline Alkaloids Alkaloids Phenols Polyphenols Structural Classification Lauraceae Plants Source classification Lindera aggregata (Sims) Kosterm. Disease Research Fields Classification of Application Fields Cardiovascular Disease
Reticuline shows anti-inflammatory effects through JAK2/STAT3 and *NF-κB* signaling pathways. Reticuline inhibits mRNA expressions of TNF-α, and IL-6 and reduces the phosphorylation levels of JAK2 and STAT3. Reticuline exhibits cardiovascular effects.

HY-N2098

Obtusifolin	NF-κB	Quinones Anthraquinones Phenols Polyphenols Classification of Application Fields Disease Research Fields Cancer Source classification Plants Leguminosae seeds of Cassia tora Linn. other families
Obtusifolin, isolated from the seeds of Cassia obtusifolia, regulates the gene expression and production of MUC5AC mucin in airway epithelial cells via inhibiting *NF-kB* pathway. Obtusifolin suppresses phthalate esters-induced breast cancer bone metastasis by targeting parathyroid hormone-related protein.

HY-101402

Cyclo(his-pro) Cyclo(histidyl-proline); Histidylproline diketopiperazine	NF-κB Endogenous Metabolite	Natural Products Source classification Endogenous metabolite
Cyclo(his-pro) (Cyclo(histidyl-proline)) is an orally active cyclic dipeptide structurally related to tyreotropin-releasing hormone. Cyclo(his-pro) could inhibit *NF-κB* nuclear accumulation. Cyclo(his-pro) can cross the brain-blood-barrier and affect diverse inflammatory and stress responses.

HY-N11657

Sanggenon A Sanggenone A	NF-κB Keap1-Nrf2	Structural Classification Other Flavonoids Flavonoids Morus alba L. Plants Source classification Moraceae
Sanggenon A (Sanggenone A) exerts anti-inflammatory effects by regulating NF-κB and HO-1/Nrf2 signaling pathways in BV2 and RAW264.7 cells. Sanggenon A markedly inhibits the Lipopolysaccharide (LPS; HY-D1056)-induced production of nitric oxide.

HY-N2450

Sulforaphene	Apoptosis EGFR ERK NF-κB	Natural Products Disease Research Fields Cancer Classification of Application Fields Source classification Plants Brassicaceae Raphanus sativus Linn.
Sulforaphene, isolated from radish seeds, exhibits an ED₅₀ against velvetleaf seedlings approximately 2 x 10^-4 M. Sulforaphene promotes cancer cells apoptosis and inhibits migration via inhibiting EGFR, p-ERK1/2, *NF‐κB* and other signals.

HY-N0633

Muscone	Interleukin Related TNF Receptor NF-κB NOD-like Receptor (NLR)	Ketones, Aldehydes, Acids Disease Research Fields Classification of Application Fields Cardiovascular Disease Source classification Animals
Muscone is the main active monomer of traditional Chinese medicine musk. Muscone inhibits *NF-κB* and NLRP3 inflammasome activation. Muscone remarkably decreases the levels of inflammatory cytokines (IL-1β, TNF-α and IL-6), and ultimately improves cardiac function and survival rate.

HY-N6966

Ethyl Caffeate	NF-κB NO Synthase COX PGE synthase	Structural Classification Phenols Polyphenols Compositae Plants Bidens pilosa Inflammation/Immunology Disease Research Fields Cancer Classification of Application Fields
Ethyl Caffeate is a natural phenolic compound isolated from Bidens pilosa. Ethyl caffeate suppresses *NF-κB* activation and its downstream inflammatory mediators, inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), and prostaglandin E₂ (PGE₂) in vitro or in mouse skin.

HY-N2106

Dehydroevodiamine	NF-κB COX PGE synthase NO Synthase	Indole Alkaloids Alkaloids Inflammation/Immunology Disease Research Fields Classification of Application Fields Source classification Plants Rutaceae Evodia rutaecarpa (Juss.) Benth.
Dehydroevodiamine is a major bioactive quinazoline alkaloid isolated from Evodiae Fructus, has an antiarrhythmic effect in guinea-pig ventricular myocytes. Dehydroevodiamine inhibits LPS-induced iNOS, COX-2, prostaglandin E2 (PGE2) and nuclear factor-kappa B (NF-κB) expression in murine macrophage cells.

HY-N0041

Ginsenoside Rb3 Gypenoside IV	NF-κB COX NO Synthase	Triterpenes Terpenoids Structural Classification Araliaceae Panax ginseng C. A. Meyer Plants Source classification Inflammation/Immunology Disease Research Fields Cancer Classification of Application Fields
Ginsenoside Rb3 is extracted from steamed Panax ginseng C. A. Meyer. Ginsenoside Rb3 exhibits inhibitory effect on TNFα-induced *NF-κB* transcriptional activity with an IC₅₀ of 8.2 μM in 293T cell lines. Ginsenoside Rb3 also inhibits the induction of COX-2 and iNOS mRNA.

HY-N3480

Isogosferol (+)-Isogospherol; Isogospherol	Others	Coumarins Structural Classification Phenylpropanoids Umbelliferae Heracleum rapula Franch. Plants Source classification
Isogosferol ((+)-Isogospherol; Isogospherol) is a potent anti-inflammatory agent. Isogosferol decreases LPS (HY-D1056)-stimulated NO and IL-1β expression. Isogosferol decreases the LPS (HY-D1056)-stimulated expression of iNOS, COX-2, NF-κB, and pERK1/2.

HY-126307

Urolithin B	NF-κB JNK ERK Akt AMPK Endogenous Metabolite	Phenols Monophenols Classification of Application Fields Disease Research Fields Inflammation/Immunology Source classification Endogenous metabolite
Urolithin B is one of the gut microbial metabolites of ellagitannins, and has anti-inflammatory and antioxidant effects. Urolithin B inhibits *NF-κB* activity by reducing the phosphorylation and degradation of IκBα, and suppresses the phosphorylation of JNK, ERK, and Akt, and enhances the phosphorylation of AMPK. Urolithin B is also a regulator of skeletal muscle mass.

HY-18739

Phorbol 12-myristate 13-acetate PMA; TPA; Phorbol myristate acetate	PKC SphK NF-κB	Ketones, Aldehydes, Acids Disease Research Fields Inflammation/Immunology Source classification Plants Euphorbiaceae Croton tiglium Linn.
Phorbol 12-myristate 13-acetate (PMA), a phorbol ester, is a dual SphK and protein kinase C (PKC) activator. Phorbol 12-myristate 13-acetate is a NF-κB activator. Phorbol 12-myristate 13-acetate induces differentiation in THP-1 cells.

HY-N8211

Gypenoside L	p38 MAPK ERK NF-κB	Terpenoids Triterpenes Classification of Application Fields Disease Research Fields Inflammation/Immunology Source classification Plants Cucurbitaceae Gynostemma pentaphyllum (Thunb.) Makino
Gypenoside L is a saponin that can be found in Gynostemma pentaphyllum. Gypenoside L increases the SA-β-galactosidase activity, promotes the production of senescence-associated secretory cytokines. Gypenoside L also can activate p38 and ERK MAPK pathways and NF-κB pathway to induce senescence. Gypenoside L exhibits anti-tumor and anti-inflammatory activities.

HY-N0510

Aristolochic acid A Aristolochic acid I; TR 1736	NF-κB	Alkaloids Other Alkaloids Classification of Application Fields Disease Research Fields Cancer Source classification Plants other families Aristolochiaceae Aristolochia debilis Sieb. et Zucc.
Aristolochic acid A (Aristolochic acid I; TR 1736) is the main component of plant extract Aristolochic acids, which are found in various herbal plants of genus Aristolochia and Asarum. Aristolochic acid A significantly reduces both activator protein 1 (AP-1) and *NF-κB* activities. Aristolochic acid A reduces BLCAP gene expression in human cell lines.

HY-101402A

Cyclo(his-pro) TFA Cyclo(histidyl-proline) TFA; Histidylproline diketopiperazine TFA	NF-κB Endogenous Metabolite	Natural Products Source classification Endogenous metabolite
Cyclo(his-pro) TFA (Cyclo(histidyl-proline) TFA) is an orally active cyclic dipeptide structurally related to tyreotropin-releasing hormone. Cyclo(his-pro) TFA could inhibit *NF-κB* nuclear accumulation. Cyclo(his-pro) TFA can cross the brain-blood-barrier and affect diverse inflammatory and stress responses.

HY-N3071

Picrasidine I	Apoptosis Reactive Oxygen Species	Indole Alkaloids Source classification Plants Simaroubaceae Quassia amaraL.
Picrasidine I is an anti-inflammatory and anti-osteoclastogenic dimeric alkaloid that can be isolated from Picrasma quassioides. Picrasidine I inducs cell cycle arrest, and triggers cell apoptosis by downregulats ERK and Akt pathways. Picrasidine I inhibits the activation of MAPKs, *NF-κB* and ROS generation, and suppresses the expression of c-Fos and NFATc1.

HY-N0831

Jaceosidin	Bcl-2 Family COX Apoptosis	Phenols Polyphenols Flavones Flavonoids Inflammation/Immunology Disease Research Fields Classification of Application Fields Source classification Plants Compositae Laburnum anagyroides Medic.
Jaceosidin is a flavonoid isolated from Artemisia vestita, induces apoptosis in cancer cells, activates Bax and down-regulates Mcl-1 and c-FLIP expression. Jaceosidin exhibits anti-cancer, anti-inflammatory activities, decreases leves of inflammatory markers, and suppresses COX-2 expression and NF-κB activation.

HY-108694

γ-Tocotrienol	Endogenous Metabolite NF-κB	Monophenols Phenols Structural Classification other families Plants Source classification Inflammation/Immunology Disease Research Fields Classification of Application Fields
γ-Tocotrienol is an active form of vitamin E. γ-tocotrienol reverses the multidrug resistance (MDR) of breast cancer cells through the signaling pathway of NF-κB and P-gp. γ-Tocotrienol is also a novel radioprotector agent, can mitigate bone marrow radiation damage during targeted radionuclide treatment.

HY-N0104

Curcumol (-)-Curcumol	Apoptosis	Terpenoids Sesquiterpenes Classification of Application Fields Disease Research Fields Cancer Source classification Plants Zingiberaceae Curcuma zedoaria
Curcumol ((-)-Curcumol), a bioactive sesquiterpenoid, possesses numerous pharmacological activities like anticancer, antimicrobial, antifungal, antiviral, and antiinflammatory. Curcumol is a potent inducer of apoptosis in numerous cancer cells via targeting key signaling pathways as MAPK/ERK, PI3K/Akt and NF-κB which are generally deregulated in several cancers.

HY-N6607

Tryptanthrin	Leukotriene Receptor NO Synthase NF-κB COX TNF Receptor Interleukin Related	Indole Alkaloids Alkaloids Inflammation/Immunology Disease Research Fields Classification of Application Fields Source classification Plants Polygonaceae Polygonum tinctorium Ait.
Tryptanthrin is an indole quinazoline that could be an alkaloid from indigo-bearing plants. Tryptanthrin is a potent and orally active cellular Leukotriene (LT) biosynthesis inhibitor. Tryptanthrin has anticancer activity. Tryptanthrin suppresses the expression levels of NOS1, COX-2, and NF-κB and regulates the expression levels of IL-2, IL-10, and TNF-α.

HY-N7056

4'-Hydroxychalcone	Proteasome	Flavonoids Chalcones Phenols Monophenols Classification of Application Fields Disease Research Fields Inflammation/Immunology Source classification Plants Leguminosae Glycyrrhiza uralensis Fisch. Endogenous metabolite
4'-Hydroxychalcone is a chalcone isolated from licorice root, with hepatoprotective activity. 4'-Hydroxychalcone inhibits TNFα-induced NF-κB activation via proteasome inhibition. 4'-Hydroxychalcone induces a rapid potassium release from mitochondrial vesicles and causes deterioration of respiratory control and oxidative phosphorylation of isolated rat liver mitochondria.

HY-N6009

8-Deoxygartanin	Parasite NF-κB	Phenols Xanthones Polyphenols Infection Disease Research Fields Classification of Application Fields Source classification Plants other families
8-Deoxygartanin, a prenylated xanthones from G. mangostana, is a selective inhibitor of butyrylcholinesterase (BChE). 8-Deoxygartanin exhibits antiplasmodial activity with an IC₅₀ of 11.8 μM for the W2 strain of Plasmodium falciparum. 8-Deoxygartanin inhibits NF-κB (p65) activation with an IC₅₀ of 11.3 μM.

HY-N6246

Asperulosidic Acid	NF-κB ERK	Iridoids Terpenoids Inflammation/Immunology Disease Research Fields Classification of Application Fields Source classification Plants Rubiaceae Morinda officinalis How
Asperulosidic Acid (ASPA), a bioactive iridoid glycoside, is extracted from the herbs of Hedyotis diffusa Willd. Asperulosidic Acid (ASPA) has anti-tumor, anti-oxidant, and anti-inflammatory activities. ASPA is related to the inhibition of inflammatory cytokines (TNF-α, IL-6) and mediators via suppression of the *NF-κB* and mitogen-activated protein kinase (MAPK) signaling pathways.

HY-N0634

Cimifugin Cimitin	NF-κB	Coumarins Structural Classification Phenylpropanoids Ranunculaceae Plants Cimicifuga racemosa Inflammation/Immunology Disease Research Fields Classification of Application Fields
Cimifugin (Cimitin) is a bioactive component of Cimicifuga racemosa, a Chinese herb. Cimifugin suppresses allergic inflammation by reducing epithelial derived initiative key factors via regulating tight junctions. Cimifugin reduces the migration and chemotaxis of RAW264.7 cells and inhibits the release of inflammatory factors and activation of MAPKs and NF-κB signaling pathways induced by LPS.

HY-14621

Zingerone Vanillylacetone; Gingerone	NF-κB	Phenols Monophenols Ketones, Aldehydes, Acids Classification of Application Fields Disease Research Fields Inflammation/Immunology Metabolic Disease Source classification Plants Zingiberaceae Zingiber officinale
Zingerone (Vanillylacetone) is a nontoxic methoxyphenol isolated from Zingiber officinale, with potent anti-inflammatory, antidiabetic, antilipolytic, antidiarrhoeic, antispasmodic and anti-tumor properties. Zingerone alleviates oxidative stress and inflammation, down-regulates NF-κB mediated signaling pathways. Zingerone acts as an anti-mitotic agent, and inhibits the growth of neuroblastoma cells.

HY-N1930

(-)-Hinesol Hinesol	Apoptosis	Natural Products Plants Compositae Erythrina sigmoidea Hua
(-)-Hinesol (Hinesol) is a potent anticancer agent. (-)-Hinesol induces apoptosis and cell cycle arrest at G0/G1 phase. (-)-Hinesol downregulates MEK/ERK pathway and NF-κB pathway and mediates theexpression of cyclin D1, Bax and Bcl-2. (-)-Hinesol has the potential for the research of non–small cell lung cancer.

HY-N8884

Coelonin	PTEN Akt NF-κB Interleukin Related TNF Receptor	Structural Classification Phenols Polyphenols Source classification Plants Orchidaceae Appendicula reflexa Blume
Coelonin is a dihydrophenanthrene with anti-inflammation activity. Coelonin inhibits LPS-induced PTEN phosphorylation. Coelonin inhibits *NF-κB* activation and p27Kip1 degradation by regulating the PI3K/AKT pathway negatively. Coelonin can inhibit IκBα phosphorylation and degradation and increases the expression of IκBα protein.

HY-N10047

7,8-Didehydrocimigenol	NF-κB PPAR	Triterpenes Terpenoids Structural Classification Ranunculaceae Cimicifuga foetida Linn. Plants Source classification
7,8-Didehydrocimigenol is an active triterpenoid that can be isolated from Cimicifugae rhizoma. 7,8-Didehydrocimigenol inhibits TNF-α-induced VCAM-1 expression, inhibits *NF-kB* activity and phosphorylation of ERK1/2 and Akt, increases PPAR-γ expression. 7,8-Didehydrocimigenol can be used for the research of cardiovascular disorders such as atherosclerosis.

HY-107818

4-Hydroxychalcone	NF-κB	Flavonoids Chalcones Phenols Monophenols Classification of Application Fields Disease Research Fields Cardiovascular Disease Source classification Plants other families
4-Hydroxychalcone is a chalcone metabolite with anti-angiogenic and anti-inflammatory activities. 4-Hydroxychalcone suppresses angiogenesis by suppression of growth factor pathway with no signs of cytotoxicity. 4-Hydroxychalcone inhibits TNF-α induced *NF-κB* pathway activation and activates BMP signaling, reduces resistant hypertension (RH) by attenuating hyperaldosteronism and renal injury in mice.

HY-N0665

Specnuezhenide (8E)-Nuezhenide	NF-κB Wnt	Iridoids Monophenols Terpenoids Phenols Inflammation/Immunology Disease Research Fields Classification of Application Fields Source classification Plants Oleaceae Ligustrum lucidum Ait.
Specnuezhenide ((8E)-Nuezhenide) is isolated from the fruits of Ligustrum lucidum. Specnuezhenide ((8E)-Nuezhenide) can inhibit IL-1β-induced inflammation in chondrocytes via inhibition of *NF-κB* and wnt/β-catenin signaling. Specnuezhenide ((8E)-Nuezhenide) exerts anti-inflammatory effects in a rat model of osteoarthritis (OA).

HY-N2259

Curcumenol (+)-Curcumenol	Cytochrome P450	Sesquiterpenes Terpenoids Inflammation/Immunology Neurological Disease Disease Research Fields Cancer Classification of Application Fields Source classification Plants Zingiberaceae Curcuma zedoaria
Curcumenol ((+)-Curcumenol) is a potent CYP3A4 inhibitor with an IC₅₀ of 12.6 μM, which is one of constituents in the plants of medicinally important genus of Curcuma zedoaria, with neuroprotection, anti-inflammatory, anti-tumor and hepatoprotective activities. Curcumenol ((+)-Curcumenol) suppresses Akt-mediated NF-κB activation and p38 MAPK signaling pathway in LPS-stimulated BV-2 microglial cells.

HY-N6966A

Ethyl trans-caffeate	Others	Compositae Lactuca perennis Plants Source classification
Ethyl trans-caffeate is the trans form of Ethyl Caffeate (HY-N6966). Ethyl Caffeate is a natural phenolic compound isolated from Bidens pilosa. Ethyl caffeate suppresses *NF-κB* activation and its downstream inflammatory mediators, inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), and prostaglandin E₂ (PGE₂) in vitro or in mouse skin.

HY-N0460

1-Caffeoylquinic acid	NF-κB	Phenols Polyphenols Classification of Application Fields Disease Research Fields Cancer Source classification Plants Compositae Phyllodium pulchellum (L.) Desv.
1-Caffeoylquinic acid is an effective *NF-κB* inhibitor, shows significant binding affinity to the RH domain of p105 with K_i of 0.002 μM and binding energy of 1.50 Kcal/mol. 1-Caffeoylquinic acid has anti-oxidative stress ability. 1-Caffeoylquinic acid inhibits PD-1/PD-L1 interact.

HY-134000

Emodic acid NSC624610	p38 MAPK NF-κB ERK JNK VEGFR MMP	Quinones Anthraquinones Structural Classification Leguminosae Plants Source classification Cercis chinensis Bunge
Emodic acid (NSC624610) is an anthraquinone compound isolated from A. microcarpus, which can inhibit the proliferation of cancer cells by inhibiting the activity of *NF-κB. Emodic acid can also inhibit the phosphorylation of p38, ERK* and JNK, the secretion of tumor-promoting cytokines IL-1β and IL-6, and the expression of VEGF and MMP, thereby inhibiting the invasion and migration potential of cancer cells.

HY-N0631

Cornuside	p38 MAPK NF-κB	Iridoids Terpenoids Phenols Polyphenols Structural Classification Cornus officinalis Sieb. et Zucc. Cornaceae Plants Source classification Inflammation/Immunology Disease Research Fields Classification of Application Fields
Cornuside is a secoiridoid glucoside isolated from the fruit of Cornus officinalis Sieb. et Zucc., which is a traditional oriental medicine for treating inflammatory diseases and invigorating blood circulation. Cornuside inhibits mast cell-mediated allergic response by down-regulating MAPK and *NF-κB* signaling pathways. Cornuside has anti-allergic effects in vivo and in vitro which suggests a therapeutic application of this agent in inflammatory allergic diseases.

HY-N2453

Convallatoxin	PPAR NF-κB P-glycoprotein	Triterpenes Structural Classification Terpenoids Ranunculaceae Plants Adonis amurensis Regel et Radde Inflammation/Immunology Disease Research Fields Classification of Application Fields
Convallatoxin is a cardiac glycoside isolated from Adonis amurensis Regel et Radde. Convallatoxin ameliorates colitic inflammation via activation of PPARγ and suppression of *NF-κB*. Convallatoxin is a P-glycoprotein (P-gp) substrate and recognized Val982 as an important amino acid involved in its transport. Convallatoxin is an enhancer of ligand-induced MOR endocytosis with high potency and efficacy. Anti-inflammatory and anti-proliferative properties.

HY-19356

Rocaglamide Roc-A	NF-κB HSP Eukaryotic Initiation Factor (eIF)	Alkaloids Other Alkaloids Classification of Application Fields Disease Research Fields Cancer Source classification Plants Meliaceae Aglaia elliptifolia
Rocaglamide (Roc-A) is isolated from the genus Aglaia and can be used for coughs, injuries, asthma and inflammatory skin diseases. Rocaglamide is a potent inhibitor of *NF-κB* activation in T-cells. Rocaglamide is a potent and selective heat shock factor 1 (HSF1) activation inhibitor with an IC₅₀ of ~50 nM. Rocaglamide inhibits the function of the translation initiation factor eIF4A. Rocaglamide also has anticancer properties in leukemia.

HY-N0603

20(S)-Ginsenoside Rg3 20(S)-Propanaxadiol; S-ginsenoside Rg3	Sodium Channel Potassium Channel NF-κB COX Amyloid-β Endogenous Metabolite	Terpenoids Triterpenes Classification of Application Fields Disease Research Fields Inflammation/Immunology Neurological Disease Source classification Plants Araliaceae Panax ginseng C. A. Meyer Endogenous metabolite
20(S)-Ginsenoside Rg3 is the main component of Panax ginseng C. A. Meyer. Ginsenoside Rg3 inhibits Na⁺ and hKv1.4 channel with IC₅₀s of 32.2±4.5 and 32.6±2.2 μM, respectively. 20(S)-Ginsenoside Rg3 also inhibits Aβ levels, *NF-κB* activity, and COX-2 expression.

HY-N6727

Gliotoxin Aspergillin	Apoptosis PKA NF-κB Bacterial Fungal Antibiotic	Antibiotics Other Antibiotics Biological Pesticide Research Inflammation/Immunology Infection Disease Research Fields Agricultural Research Classification of Application Fields Source classification Microorganisms
Gliotoxin is a secondary metabolite, the most abundant mycotoxin secreted by A. fumigatus, inhibits the phagocytosis of macrophages and the immune functions of other immune cells . Gliotoxin inhibits inducible *NF-κB* activity by preventing IκB degradation, which consequently induces host-cell apoptosis. Gliotoxin activates PKA and increases intracellular cAMP concentration; modulates actin cytoskeleton rearrangement to facilitate A. fumigatus internalization into lung epithelial cells.

HY-N2205

Esculentoside H	NF-κB JNK	Triterpenes Terpenoids Disease Research Fields Cancer Classification of Application Fields Source classification Plants Phytolaccaceae Phytolacca acinosa Roxb.
Esculentoside H (EsH) is a saponin isolated from the root extract of perennial plant Phytolacca esculenta. Esculentoside H (EH) has anti-tumor activity, the mechanism is related to the capacity for TNFrelease. Esculentoside H (EsH) suppresses colon cancer cell migration through blockage of the JNK1/2 and *NF-κB* signaling-mediated matrix metalloproteinases-9 (MMP-9) expression.

HY-B2163

Astaxanthin	PPAR Reactive Oxygen Species STAT NF-κB Apoptosis	Terpenoids Diterpenoids Research on Agricultural Breeding Pigments Disease Research Fields Food Research Anti-aging Agricultural Research Classification of Application Fields Cardiovascular Disease Source classification Microorganisms
Astaxanthin, the red dietary carotenoid, is an orally effective and potent antioxidant. Astaxanthin inhibits *NF-κB* and down-regulates VEGF in blood glucose. Astaxanthin exerts anti-cancer cell proliferation, increases apoptosis, impairs migration and invasion by activating PPARγ and reducing the expression of STAT3. Astaxanthin also has neuroprotective and anti-inflammatory activity and can be used in studies of cancer, diabetic retinopathy, cardiovascular disease, and in the coloring of animal feed.

HY-N0498

Nitidine chloride	Parasite Apoptosis STAT Topoisomerase ERK FAK p38 MAPK NF-κB	Isoquinoline Alkaloids Alkaloids Inflammation/Immunology Disease Research Fields Classification of Application Fields Source classification Plants Rutaceae Zanthoxylum nitidum (Roxb.) DC.
Nitidine chloride, a potential anti-malarial lead compound derived from Zanthoxylum nitidum (Roxb) DC, exerts potent anticancer activity through diverse pathways, including inducing apoptosis, inhibiting STAT3 signaling cascade, DNA topoisomerase 1 and 2A, ERK and c-Src/FAK associated signaling pathway. Nitidine chloride inhibits LPS-induced inflammatory cytokines production via MAPK and *NF-kB* pathway.

HY-N1326

Santamarine Santamarin; Balchanin	Others	Terpenoids Sesquiterpenes Classification of Application Fields Disease Research Fields Inflammation/Immunology Source classification Plants Magnoliaceae Magnolia grandiflora L.
Santamarine (Santamarin), a sesquiterpene lactone, increases HO-1 expression through Nrf2 translocation and suppresses NO, PGE2, TNF-α, and IL-1β production through inhibition of NF-κB translocation in LPS-induced macrophages. Santamarine shows anti-photoaging properties via inhibition of MAPK/AP-1 and stimulation of TGF-β/Smad signaling in UVA-irradiated human dermal fibroblasts (HDFs). Antioxidant activities.

HY-N0822

Shikonin C.I. 75535; Isoarnebin 4	Chloride Channel Pyruvate Kinase NF-κB TNF Receptor HIV AIM2	Quinones Structural Classification Naphthalene Quinones Boraginaceae Lithospermum erythrorhizon Sieb. et Zucc. Plants Disease Research Fields Cancer Classification of Application Fields
Shikonin is a major component of a Chinese herbal medicine named zicao. Shikonin is a potent TMEM16A chloride channel inhibitor with an IC₅₀ of 6.5 μM. Shikonin is a specific pyruvate kinase M2 (PKM2) inhibitor and can also inhibit TNF-α and *NF-κB* pathway. Shikonin decreases exosome secretion through the inhibition of glycolysis. Shikonin inhibits AIM2 inflammasome activation.

HY-N2056

11-Keto-beta-boswellic acid 11-Keto-β-boswellic acid	Lipoxygenase Leukotriene Receptor NF-κB	Triterpenes Terpenoids Disease Research Fields Cancer Classification of Application Fields Source classification Plants Burseraceae Boswellia serrata
11-Keto-beta-boswellic acid (11-Keto-β-boswellic acid) is a pentacyclic triterpenic acid of the oleogum resin from the bark of the Boswellia serrate tree, popularly known as Indian Frankincense. 11-Keto-beta-boswellic acid has the anti-inflammatory activity is primarily due to inhibit 5-lipoxygenase (5-LOX) and subsequent leukotriene and nuclear factor-kappa B (NF-κB) activation and tumor necrosis factor alpha generation production.

HY-N0751

Scutellarin	STAT Akt HIV	Structural Classification Phenols Polyphenols Flavones Flavonoids Infection Disease Research Fields Classification of Application Fields Source classification Plants Labiatae Scutellaria baicalensis Georgi
Scutellarin, an active flavone isolated from Scutellaria baicalensis, can down-regulates the STAT3/Girdin/Akt signaling in HCC cells, and inhibits RANKL-mediated MAPK and NF-κB signaling pathway in osteoclasts. Scutellarin is active against HIV-1IIIB, HIV-1(74V) and HIV-1KM018 with EC₅₀s of 26 μM, 253 μM and 136 μM, respectively.

HY-N0619

Mulberroside A	TNF Receptor Interleukin Related Tyrosinase	Phenols Stilbenes Polyphenols Structural Classification Morus alba L. Plants Source classification Moraceae Inflammation/Immunology Disease Research Fields Classification of Application Fields
Mulberroside A is one of the main bioactive constituent in mulberry (Morus alba L.). Mulberroside A decreases the expressions of TNF-α, IL-1β, and IL-6 and inhibits the activation of NALP3, caspase-1, and NF-κB and the phosphorylation of ERK, JNK, and p38, exhibiting anti-inflammatory antiapoptotic effects. Mulberroside A shows inhibitory activity against mushroom tyrosinase with an IC₅₀ of 53.6 μM.

HY-N0005

Curcumin Diferuloylmethane; Natural Yellow 3; Turmeric yellow	Histone Acetyltransferase Epigenetic Reader Domain Keap1-Nrf2 Autophagy Mitophagy Influenza Virus Ferroptosis	Phenols Polyphenols Pigments Disease Research Fields Cancer Food Research Anti-aging Classification of Application Fields Source classification Plants Zingiberaceae Curcuma longa
Curcumin (Diferuloylmethane), a natural phenolic compound, is a p300/CREB-binding protein-specific inhibitor of acetyltransferase, represses the acetylation of histone/nonhistone proteins and histone acetyltransferase-dependent chromatin transcription. Curcumin shows inhibitory effects on *NF-κB* and MAPKs, and has diverse pharmacologic effects including anti-inflammatory, antioxidant, antiproliferative and antiangiogenic activities. Curcumin induces stabilization of Nrf2 protein through Keap1 cysteine modification.

HY-N3364

Lucidone	TNF Receptor NF-κB NO Synthase COX JNK p38 MAPK IKK	Structural Classification Natural Products Lindera lucida (Blume) Boerl. Lauraceae Plants Source classification
Lucidone, an anti-inflammatory agent that can be isolated from the fruit of Lindera erythrocarpa Makino. Lucidone inhibits LPS-induced NO and PGE₂ production in RAW 264.7 mouse macrophages. Lucidone also decreases TNF-α secretion, iNOS and COX-2 expression. Lucidone prevents *NF-κB* translocation and inhibits JNK and p38MAPK signals. Lucidone also has inhibitory activity against Dengue virus (DENV) (EC₅₀=25 μM).

HY-N3807

Enniatin B1	Acyltransferase ERK NF-κB	Alkaloids Other Alkaloids Classification of Application Fields Disease Research Fields Cardiovascular Disease Infection Source classification Microorganisms
Enniatin B1 is a Fusarium mycotoxin. Enniatin B1 inhibits acyl-CoA: cholesterol acyltransferase (ACAT) activity with an IC₅₀ of 73 μM in an enzyme assay using rat liver microsomes. Enniatin B1 crosss the blood-brain barrier. Enniatin B1 decreases the activation of ERK (p44/p42). Enniatin B1 inhibits moderately TNF-α-induced *NF-κB* activation.

HY-N4314

Scutellarein tetramethyl ether 4',5,6,7-Tetramethoxyflavone	Bacterial	Flavones Structural Classification Flavonoids Compositae Eupatorium odoratum Plants Inflammation/Immunology Infection Disease Research Fields Classification of Application Fields
Scutellarein tetramethyl ether (4',5,6,7-Tetramethoxyflavone) is a bioactive component of Siam weed extract. Scutellarein tetramethyl ether (4',5,6,7-Tetramethoxyflavone) exhibits anti-inflammatory activity through NF-κB pathway. Scutellarein tetramethyl ether (4',5,6,7-Tetramethoxyflavone) modulats of bacterial agent resistance via efflux pump inhibition. Scutellarein tetramethyl ether (4',5,6,7-Tetramethoxyflavone) can enhance blood coagulation.

HY-N0811

Anemarsaponin B	NO Synthase COX NF-κB MEK	Steroids Structural Classification Anemarrhena asphodeloides Bunge Liliaceae Plants Source classification Inflammation/Immunology Disease Research Fields Classification of Application Fields
Anemarsaponin B is a steroidal saponin. Anemarsaponin B decreases the protein and mRNA levels of iNOS and COX-2. Anemarsaponin B reduces the expressions and productions of pro-inflammatory cytokines, including TNF-a and IL-6. Anemarsaponin B inhibits the nuclear translocation of the p65 subunit of *NF-κB* by blocking the phosphorylation of IκBα. Anemarsaponin B also inhibits the phosphorylation of MAP kinase kinases 3/6 (MKK3/6) and mixed lineage kinase 3 (MLK3). Anti-inflammatory effect .

HY-N6257

Cafestol	ERK PGE synthase COX NF-κB	Terpenoids Diterpenoids Inflammation/Immunology Disease Research Fields Cancer Classification of Application Fields Plants Rubiaceae
Cafestol, one of the major components of coffee, is a coffee-specific diterpene from. Cafestol is a ERK inhibitor for AP-1-targeted activity against PGE₂ production and the mRNA expression of cyclooxygenase (COX)-2 in LPS-activated RAW264.7 cells. Cafestol has strong inhibitory activity on PGE₂ production by suppressing the *NF-kB* activation pathway. Cafestol contributes to its beneficial effects through various biological activities such as chemopreventive, antitumorigenic, hepatoprotective, antioxidative and antiinflammatory effects.

HY-N0632

Esculentoside A	COX NF-κB	Triterpenes Terpenoids Inflammation/Immunology Disease Research Fields Classification of Application Fields Source classification Plants Phytolaccaceae Phytolacca acinosa Roxb.
Esculentoside A (EsA), a kind of triterpene saponin isolated from roots of Phytolacca esculenta. Esculentoside A (EsA) possesses anti-inflammatory activity in acute and chronic experimental models, has selective inhibitory activity towards cyclooxygenase-2 (COX-2). Esculentoside A (EsA) suppresses inflammatory responses in LPS-induced acute lung injury (ALI) through inhibition of the nuclear factor kappa B (NF-ΚB) and mitogen activated protein kinase (MAPK) signaling pathways.

HY-N0619A

cis-Mulberroside A Mulberroside D	TNF Receptor Interleukin Related Tyrosinase	Phenols Stilbenes Polyphenols Inflammation/Immunology Disease Research Fields Classification of Application Fields Source classification Plants Moraceae Morus alba Linn.
cis-Mulberroside A (Mulberroside D) is the cis-isomer of Mulberroside A. Mulberroside A is one of the main bioactive constituent in mulberry (Morus alba L.). Mulberroside A decreases the expressions of TNF-α, IL-1β, and IL-6 and inhibits the activation of NALP3, caspase-1, and NF-κB and the phosphorylation of ERK, JNK, and p38, exhibiting anti-inflammatory and anti-apoptotic effects. Mulberroside A shows inhibitory activity against mushroom tyrosinase with an IC₅₀ of 53.6 μM.

HY-N0755

Rhoifolin	Insulin Receptor GLUT NF-κB p38 MAPK Autophagy	Structural Classification Flavones Flavonoids Anacardiaceae Plants Rhus succedanea Disease Research Fields Cancer Classification of Application Fields Endocrinology
Rhoifolin is a flavone glycoside can be isolated from Rhus succedanea. Rhoifolin has anti-diabetic effect acting through enhanced adiponectin secretion, tyrosine phosphorylation of insulin receptor-β and glucose transporter 4 (GLUT 4) translocation. Rhoifolin has an anti-inflammatory action via multi-level regulation of inflammatory mediators. Rhoifolin ameliorates titanium particle-stimulated osteolysis and attenuates osteoclastogenesis via RANKL-induced *NF-κB* and MAPK pathways. Rhoifolin also has cytotoxic activity against different cancer cell lines.

HY-N1445

Isoquercetin Quercetin 3-glucoside	NF-κB NO Synthase	Flavonols Phenols Polyphenols Structural Classification Flavonoids Apocynaceae Apocynum venetum Linn. Plants Source classification Disease Research Fields Cancer Classification of Application Fields
Isoquercetin (Quercetin 3-glucoside) is a naturally occurring polyphenol that has antioxidant, anti-proliferative, and anti-inflammatory properties. Isoquercetin alleviates ethanol-induced hepatotoxicity, oxidative stress, and inflammatory responses via the Nrf2/ARE antioxidant signaling pathway. Isoquercetin regulates the expression of nitric oxide synthase 2 (NO2) via modulating the nuclear factor-κB (NF-κB) transcription regulation system. Isoquercetin has high bioavailability and low toxicity, is a promising candidate agent to prevent birth defects in diabetic pregnancies.

HY-N0408

Picroside II	NF-κB Reactive Oxygen Species Apoptosis Influenza Virus	Structural Classification Iridoids Terpenoids Scrophulariaceae Plants Picrorhiza scrophulariiflora Pennell Inflammation/Immunology Neurological Disease Infection Disease Research Fields Classification of Application Fields
Picroside II, an iridoid compound extracted from Picrorhiza, exhibits anti-inflammatory and anti-apoptotic activities. picroside II alleviates the inflammatory response in sepsis and enhances immune function by inhibiting the activation of NLRP3 inflammasome and *NF-κB* pathways. Picroside II is an antioxidant, exhibits a significant neuroprotective effect through reducing ROS production and protects the blood-brain barrier (BBB) after cerebral ischemia-reperfusion (CI/R) injury. Picroside II has antioxidant, anti-inflammatory, immune regulatory, anti-virus and other pharmacological activities.

HY-B0809

Theophylline 1,3-Dimethylxanthine; Theo-24	Phosphodiesterase (PDE) Adenosine Receptor HDAC Apoptosis Interleukin Related TNF Receptor Endogenous Metabolite	Alkaloids Other Alkaloids Structural Classification Camellia sinensis (L.) O. Ktze. Immune System Disorder Endogenous metabolite Disease markers Plants Source classification Theaceae Disease Research Fields Cancer Classification of Application Fields
Theophylline (1,3-Dimethylxanthine) is a potent phosphodiesterase (PDE) inhibitor, adenosine receptor antagonist, and histone deacetylase (HDAC) activator. Theophylline (1,3-Dimethylxanthine) inhibits PDE3 activity to relax airway smooth muscle. Theophylline (1,3-Dimethylxanthine) has anti-inflammatory activity by increase IL-10 and inhibit NF-κB into the nucleus. Theophylline (1,3-Dimethylxanthine) induces apoptosis. Theophylline (1,3-Dimethylxanthine) can be used for asthma and chronic obstructive pulmonary disease (COPD) research.

HY-N0427

Phellodendrine	Akt NF-κB	Alkaloids Phenols Quinoline Alkaloids Polyphenols Inflammation/Immunology Disease Research Fields Classification of Application Fields Source classification Plants Rutaceae Phellodendron amurense Rupr.
Phellodendrine, a isoquinoline alkaloid, is one of important characteristic ingredients in the Phellodendron amurense. phellodendrine is against AAPH-induced oxidative stress through regulating the *AKT/NF-κB* pathway. Phellodendrine has good antioxidant, and anti-inflammatory effect .

HY-N0515

Ophiopogonin D	PPAR NF-κB Calcium Channel	Steroids Disease Research Fields Classification of Application Fields Cardiovascular Disease Source classification Plants Liliaceae Ophiopogon japonicus (L. f.) Ker-Gawl.
Ophiopogonin D, isolated from the tubers of Ophiopogon japonicus, is a rare naturally occurring C₂₉ steroidal glycoside. Ophiopogonin D is a CYP2J3 inducer that significantly inhibits Ang II induced NF-κB nuclear translocation, IκBα down-regulation, intracellular Ca²⁺ overload and activation of pro-inflammatory cytokines by increasing the expression of CYP2J2/EETs and PPARα in human umbilical vein endothelial cells (HUVECs). Ophiopogonin D has been used to treat inflammatory and cardiovascular diseases for thousands of years.

HY-N0373

Licochalcone B	Amyloid-β Apoptosis NOD-like Receptor (NLR)	Chalcones Flavonoids Source classification Plants Leguminosae Glycyrrhiza uralensis Fisch.
Licochalcone B is an extract from the root of Glycyrrhiza uralensis. Licochalcone B inhibits amyloid β (₄₂) self-aggregation (IC₅₀=2.16 μM) and disaggregate pre-formed Aβ₄₂ fibrils, reduce metal-induced Aβ₄₂ aggregation through chelating metal ionsLicochalcone B inhibits phosphorylation of NF-κB p65 in LPS signaling pathway. Licochalcone B inhibits growth and induces apoptosis of NSCLC cells. Licochalcone B specifically inhibits the NLRP3 inflammasome by disrupting NEK7‐NLRP3 interaction.

HY-N0043

Ginsenoside Rd Gypenoside VIII	NF-κB COX Calcium Channel Cytochrome P450 Endogenous Metabolite	Triterpenes Terpenoids Disease Research Fields Cancer Classification of Application Fields Cardiovascular Disease Source classification Plants Araliaceae Panax ginseng C. A. Meyer Endogenous metabolite
Ginsenoside Rd inhibits TNFα-induced *NF-κB* transcriptional activity with an IC₅₀ of 12.05±0.82 μM in HepG2 cells. Ginsenoside Rd inhibits expression of COX-2 and iNOS mRNA. Ginsenoside Rd also inhibits Ca²⁺ influx. Ginsenoside Rd inhibits CYP2D6, CYP1A2, CYP3A4, and CYP2C9, with IC₅₀s of 58.0±4.5 μM, 78.4±5.3 μM, 81.7±2.6 μM, and 85.1±9.1 μM, respectively.

HY-N10106

Dihydromyristicin	Reactive Oxygen Species	Natural Products Classification of Application Fields Disease Research Fields Inflammation/Immunology Source classification Plants Umbelliferae Ligusticum scoticum
Dihydromyristicin, a plant flavonoid, has potent anti-inflammatory properties. Dihydromyristicin reduces endotoxic inflammation via repressing ROS-mediated activation of PI3K/Akt/NF-κB signaling pathways.

HY-N0705

Curculigoside	JAK STAT NF-κB	Monophenols Phenols Neurological Disease Disease Research Fields Cancer Classification of Application Fields Source classification Plants Amaryllidaceae Curculigo orchioides Gaertn.
Curculigoside is the main saponin in C. orchioide, exerts significant antioxidant, anti-osteoporosis, antidepressant and neuroprotection effects. Curculigoside possesses significant anti-arthritic effects in vivo and in vitro via regulation of the *JAK/STAT/NF-κB* signaling pathway.

HY-N0617

Sanggenon C	NF-κB	Phenols Flavanonols Polyphenols Flavonoids Inflammation/Immunology Disease Research Fields Classification of Application Fields Cardiovascular Disease Source classification Plants Moraceae Morus alba Linn.
Sanggenon C is a flavanone Diels-Alder adduct compound, which is isolated from Cortex Mori (Sang Bai Pi). Sanggenon C exerts protective effects against cardiac hypertrophy and fibrosis via suppression of the calcineurin/NFAT2 pathway. Sanggenon C inhibits inducible nitric oxide synthase expression in RAW264.7 cells, and tumor necrosis factor-α-stimulated cell adhesion and vascular cell adhesion molecule-1 expression, by suppressing *NF-κB* activity. Sanggenon C possesses antioxidant, anti-inflammatory activities and inhibits Pancreatic lipase (PL) with the an IC₅₀ of 3.00 μM.

HY-N2485

4'-Methoxyresveratrol 4'-O-Methylresveratrol	NF-κB NOD-like Receptor (NLR)	Phenols Stilbenes Polyphenols Inflammation/Immunology Disease Research Fields Classification of Application Fields Source classification Plants Polygonaceae Rheum palmatum L.
4'-Methoxyresveratrol (4'-O-Methylresveratrol) is a polyphenol derived from Dipterocarpaceae, with antiandrogenic, antifungal and anti-inflammatory activities. 4'-Methoxyresveratrol alleviates AGE-induced inflammation through suppressing RAGE-mediated MAPK/NF-κB signaling pathway and NLRP3 inflammasome activation.

HY-N2515

Ginsenoside Rk1	NF-κB PI3K JAK Apoptosis	Triterpenes Terpenoids Inflammation/Immunology Disease Research Fields Classification of Application Fields Source classification Plants Araliaceae Panax ginseng C. A. Meyer
Ginsenoside Rk1 is a unique component created by processing the ginseng plant (mainly Sung Ginseng, SG) at high temperatures. Ginsenoside Rk1 has anti-inflammatory effect, suppresses the activation of Jak2/Stat3 signaling pathway and *NF-κB. Ginsenoside Rk1 has anti-tumor effect, antiplatelet aggregation activities, anti-insulin resistance, nephroprotective effect, antimicrobial effect, cognitive function enhancement, lipid accumulation reduction and prevents osteoporosis. Ginsenoside Rk1 induces cell apoptosis by triggering intracellular reactive oxygen species (ROS) generation and blocking PI3K/Akt* pathway.

HY-N7043

Isosilybin A	Apoptosis	Flavonoids Flavanonols Phenols Polyphenols Classification of Application Fields Disease Research Fields Cancer Source classification Plants Compositae Glycine soya Cyamopsis tetragonoloba (L.) Taub.
Isosilybin A, a flavonolignan isolated from silymarin, has anti-prostate cancer (PCA) activity. Isosilybin A inhibits proliferation and induces G1 phase arrest and apoptosis in cancer cells, which activates apoptotic machinery in PCA cells via targeting *Akt-NF-κB-androgen receptor (AR)* axis.

HY-N2855

Alphitolic acid Aophitolic acid	Apoptosis Autophagy TNF Receptor Akt NF-κB	Triterpenes Source classification Plants Myricaceae Myrica nagi
Alphitolic acid (Aophitolic acid) is an anti-inflammatory triterpene could found in quercus aliena. Alphitolic acid blocks Akt–NF-κB signaling to induce apoptosis. Alphitolic acid induces autophagy. Alphitolic acid has anti-inflammatory activity and down-regulates the NO and TNF-α production. Alphitolic acid can be used for cancer and inflammation research.

HY-N0392

Polygalasaponin F	Toll-like Receptor (TLR) PI3K Akt NF-κB	Triterpenes Terpenoids Inflammation/Immunology Disease Research Fields Classification of Application Fields Source classification Plants Polygalaceae Polygala japonica Houtt.
Polygalasaponin F, an oleanane-type triterpenoid saponin extracted from Polygala japonica, decreases the release of the inflammatory cytokine tumor necrosis factor a (TNFa). Polygalasaponin F reduces neuroinflammatory cytokine secretion through the regulation of the *TLR4-PI3K/AKT-NF-kB* signaling pathway .

HY-N2609

7,4'-Dihydroxyflavone	CCR NF-κB	Phenols Polyphenols Flavones Flavonoids Disease Research Fields Classification of Application Fields Endocrinology Source classification Plants Leguminosae Glycyrrhiza uralensis Fisch.
7,4'-Dihydroxyflavone (7,4'-DHF) is a flavonoid isolated from Glycyrrhiza uralensis, the eotaxin/CCL11 inhibitor, has the ability to consistently suppress eotaxin production and prevent dexamethasone (Dex)‐paradoxical adverse effects on eotaxin production. 7,4'-Dihydroxyflavone (7,4'-DHF) inhibits MUC5AC gene expression, mucus production and secretion via regulation of NF-κB, STAT6 and HDAC2. 7,4'-Dihydroxyflavone (7,4'-DHF) decreases phorbol 12-myristate 13-acetate (PMA) stimulated NCI-H292 human airway epithelial cell MUC5AC gene expression and mucus production with IC₅₀ value of 1.4 µM.

HY-N3387

Licoricidin	Apoptosis NF-κB Akt MMP	Phenols Polyphenols Natural Products Inflammation/Immunology Disease Research Fields Classification of Application Fields Source classification Plants Leguminosae Glycyrrhiza uralensis Fisch.
Licoricidin (LCD) is isolated from Glycyrrhiza uralensis Fisch, possesses anti-cancer activities. Licoricidin (LCD) inhibit SW480 cells (IC₅₀=7.2 μM) by inducing cycle arrest, apoptosis and autophagy, and is a potential chemopreventive or chemotherapeutic agent against colorectal cancer. Licoricidin (LCD) inhibits Lung Metastasis by inhibition of tumor angiogenesis and lymphangiogenesis as well as changes in the local microenvironment of tumor tissues the anticarcinogenic effect. Licoricidin enhanced gemcitabine-induced cytotoxicity in Osteosarcoma (OS) cells by inactivation of the Akt and *NF-κB* pathways in vitro and in vivo. Licoricidin blocks UVA-induced photoaging via ROS scavenging, limits the activity of MMP-1, it can be considered as an active ingredient in new topically applied anti-ageing formulations.

HY-N2573

Corydalmine L-Corydalmine; TLZ-16	Fungal CXCR	Isoquinoline Alkaloids Alkaloids Monophenols Phenols Source classification Plants Papaveraceae Corydalis yanhusuo W. T. Wang
Corydalmine (L-Corydalmine) inhibits spore germination of some plant pathogenic as well as saprophytic fungi. Corydalmine acts as an oral analgesic agent, exhibiting potent analgesic activity. Corydalmine alleviates Vincristine-induced neuropathic pain in mice by inhibiting an NF-κB-dependent CXCL1/CXCR2 signaling pathway.

HY-N8707

Homobutein	Parasite HDAC NF-κB	Flavonoids Chalcones Phenols Polyphenols Classification of Application Fields Disease Research Fields Cancer Infection Inflammation/Immunology Source classification Plants Compositae Wedelia asperrima (Gardner) B.L.Turner
Homobutein a natural chalcones (can be found in many medicinal plants, fruits, vegetables, spices and nuts), is a potent *HDACs/NF-κB* dual inhibitor with IC₅₀s of 190 and 38 μM, respectively. Homobutein also a chelator of iron (II and III) cations, shows various activities, including anticancer, anti-inflammatory, antiparasite and antioxidation.

HY-13295

Vinpocetine Ethyl apovincaminate	Sodium Channel IKK Phosphodiesterase (PDE)	Alkaloids Piperidine Alkaloids Indole Alkaloids Classification of Application Fields Disease Research Fields Cancer Cardiovascular Disease Neurological Disease Anti-aging Source classification Plants Apocynaceae Catharanthus roseus (L.) G. Don
Vinpocetine (Ethyl apovincaminate) is a derivative of the alkaloid Vincamine that blocks voltage-gated Na⁺ channels. The IC₅₀ value of Vinpocetine on direct IKK inhibition in the cell-free system is 17.17 μM. Vinpocetine is a phosphodiesterase (PDE) inhibitor and inhibits *NF-κB*-dependent inflammatory responses by directly targeting IκB kinase complex (IKK), and has been widely used for the treatment of cerebrovascular disorders.

HY-N2908

Atraric acid Methyl atrarate	Androgen Receptor NO Synthase p38 MAPK NF-κB	Phenols Plants
Atraric acid (Methyl atrarate) is a specific androgen receptor (AR) antagonist with anti-inflammatory and anticancer effects. Atraric acid represses the expression of the endogenous prostate specific antigen gene in both LNCaP and C4-2 cells. Atraric acid can also inhibit the synthesis of NO and cytokine, and suppress the MAPK-NFκB signaling pathway. Atraric acid can be used to research prostate diseases and inflammatory diseases.

HY-N0816

Polyphyllin VI	Apoptosis Pyroptosis	Steroids Disease Research Fields Cancer Classification of Application Fields Source classification Plants other families
Polyphyllin VI, an active saponin, possess anti-cancer activities. Polyphyllin VI induces G2/M cell cycle arrest and triggers apoptosis. Polyphyllin VI induces caspase-1-mediated pyroptosis via the induction of ROS/NF-κB/NLRP3/GSDMD signal axis in non-small cell lung cancer.

HY-N1818

Deoxysappanone B 3-Deoxysappanone B	p38 MAPK	Structural Classification Phenols Polyphenols Source classification Plants Leguminosae Caesalpinia sappan L.
Deoxysappanone B (3-Deoxysappanone B) is a homoisoflavone compound isolated from Caesalpinia sappan L (Lignum Sappan). Deoxysappanone B has anti-neuroinflammatory and neuroprotective effects and inhibits the production of neuroinflammatory mediators by blocking the IκB kinase (IKK)-NF-κB and p38/ERK MAPK pathways. Deoxysappanone B can be used in disease studies of neuritis and inflammation-related neurological damage.

HY-N0492

α-Lipoic Acid Thioctic acid; (±)-α-Lipoic acid; DL-α-Lipoic acid	NF-κB HIV Mitochondrial Metabolism Endogenous Metabolite Apoptosis	Ketones, Aldehydes, Acids Inflammation/Immunology Infection Disease Research Fields Classification of Application Fields Source classification Endogenous metabolite
α-Lipoic Acid (Thioctic acid) is an antioxidant, which is an essential cofactor of mitochondrial enzyme complexes. α-Lipoic Acid inhibits *NF-κB*-dependent HIV-1 LTR activation. α-Lipoic Acid induces endoplasmic reticulum (ER) stress-mediated apoptosis in hepatoma cells. α-Lipoic Acid can be used with CPUL1 (HY-151802) to construct the self-assembled nanoaggregate CPUL1-LA NA, which has improved antitumor efficacy than CPUL1.

HY-N6588

3,4,5-Tricaffeoylquinic acid 3,4,5-triCQA	Akt NF-κB	Phenylpropanoids Phenols Polyphenols Simple Phenylpropanols Inflammation/Immunology Disease Research Fields Classification of Application Fields Source classification Plants Convolvulaceae Ipomoea batatas (Linn.) Lamarck
3,4,5-Tricaffeoylquinic acid (3,4,5-triCQA) inhibits tumor necrosis factor-α-stimulated production of inflammatory mediators in keratinocytes via suppression of Akt- and NF-κB-pathways. 3,4,5-Tricaffeoylquinic acid induces cell cycle arrest at G0/G1, actin cytoskeleton organization, chromatin remodeling, neuronal differentiation, and bone morphogenetic protein signaling in human neural stem cells. 3,4,5-Tricaffeoylquinic acid has the potential for the research of aging-associated diseases.

HY-N1904

4′-Hydroxywogonin 8-Methoxyapigenin	IKK NF-κB p38 MAPK PI3K Akt Reactive Oxygen Species Interleukin Related TNF Receptor Apoptosis Caspase Bcl-2 Family	Flavones Flavonoids Plants Verbenaceae Verbena littoralis H.B.K.
4′-Hydroxywogonin (8-Methoxyapigenin), a flavonoid, could be isolated from a variety of plants including Scutellaria barbata and Verbena littoralis. 4′-Hydroxywogonin has anti-inflammatory activity via TAK1/IKK/NF-κB, MAPKs and PI3/AKT signaling pathways. 4′-Hydroxywogonin inhibits angiogenesis by disrupting PI3K/AKT signaling. 4′-Hydroxywogonin inhibits cell proliferation and induces apoptosis.

HY-N0492A

α-Lipoic Acid sodium Thioctic acid sodium; (±)-α-Lipoic acid sodium; DL-α-Lipoic acid sodium	NF-κB HIV Mitochondrial Metabolism Endogenous Metabolite Apoptosis	Natural Products Source classification Animals
α-Lipoic Acid (Thioctic acid) sodium is an antioxidant, which is an essential cofactor of mitochondrial enzyme complexes. α-Lipoic Acid sodium inhibits *NF-κB*-dependent HIV-1 LTR activation. α-Lipoic Acid sodium induces endoplasmic reticulum (ER) stress-mediated apoptosis in hepatoma cells. α-Lipoic Acid sodium can be used with CPUL1 (HY-151802) to construct the self-assembled nanoaggregate CPUL1-LA NA, which has improved antitumor efficacy than CPUL1.

Species:	Human (3) Mouse (1)
Tag:	His (4)
Source:	E. coli (4)

Cat. No.	Product Name	Species	Source

HY-P71124

NFKB1 Protein, Human (His)
DNA-binding factor kBF1; EBP-1; Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
Human E. coli

HY-P700147AF

Animal-Free RANK L/TNFSF11 Protein, Human (His) soluble Receptor Activator of NF-kB Ligand; TNFSF11; TRANCE (TNF-Related Activation-induced Cytokine); OPGL; ODF (Osteoclast Differentiation Factor); CD254; sRNAK Ligand	Human	E. coli

HY-P700226AF

Animal-Free RANK L/TNFSF11 Protein, Mouse (His) soluble Receptor Activator of NF-kB Ligand; TNFSF11; TRANCE (TNF-Related Activation-induced Cytokine); OPGL; ODF (Osteoclast Differentiation Factor); CD254; sRNAK Ligand	Mouse	E. coli
RANKL (TNFSF11), a type II transmembrane protein, is a receptor ligand for NF-κB (RANK). RANKL is an activator of NF-κB. When binding to NF-κB, it induces the differentiation of monocyte/macrophage-lineage cells into osteoclasts and leads to osteoclast precursor maturation. RANKL is critical for osteoclasts maturation, bone modeling, and bone remodeling, as well as the development of lymph nodes (LNs). Animal-Free RANK L/TNFSF11 Protein, Mouse (His) is a recombinant mouse RANKL (P143-D316) with C-terminal His tag, which is produced in E.coli.

HY-P71687

RANK/TNFRSF11A Protein, Human (His) CD265; FEO; TRANCER; Tumor necrosis factor receptor superfamily member 11a NFkB activator	Human	E. coli
RANK (TNFRSF11A) is a receptor activator of nuclear factor κB (NF-κB), which is involved in bone metabolism and immune system function. RANK is mainly expressed by osteoblasts/stromal cells, and is associated with the formation of giant cell tumor of bone (GCTBs) . RANK combined with RANKL ligand activated the RANKL/RANK/ OPG system to regulate bone resorption . RANKL/RANK is also a regulator of dendritic cell (DC)-T cell interaction, which is associated with mammary epithelial formation and central nervous system thermoregulation in lactating female . RANK/TNFRSF11A Protein, Human (His) has 175 amino acids (28L-202K), produced by HEK293 cells with C-terminal His-tag.

Cat. No.	Product Name

HY-78131BS

(R)-(-)-Ibuprofen-d3
(R)-(-)-Ibuprofen-d₃ is the deuterium labeled (R)-(-)-Ibuprofen. (R)-(-)-Ibuprofen is the R enantiomer of Ibuprofen, inactive on COX, inhibits NF-κB activation; (R)-(-)-Ibuprofen exhibits anti-inflammatory and antinociceptive effects.

HY-B0167S

Salicylic acid-d6
Salicylic acid-d₆ is a deuterium labeled Salicylic acid. Salicylic acid inhibits cyclo-oxygenase-2 (COX-2) activity independently of transcription factor (NF-κB) activation[1].

HY-N1380S1

Guaiacol-d3
Guaiacol-d₃ is the deuterium labeled Guaiacol. Guaiacol, a phenolic compound, inhibits LPS-stimulated COX-2 expression and NF-κB activation. Guaiacol has an anti-inflammatory activity[1].

HY-N1380S

Guaiacol-d7

Guaiacol-d₇ is the deuterium labeled Guaiacol[1]. Guaiacol, a phenolic compound, inhibits LPS-stimulated COX-2 expression and NF-κB activation[1]. Anti-inflammatory activity[2].
HY-N1380S3

Guaiacol-d4

Guaiacol-d₄ is the deuterium labeled Guaiacol[1]. Guaiacol, a phenolic compound, inhibits LPS-stimulated COX-2 expression and NF-κB activation[1]. Anti-inflammatory activity[2].

HY-N1380S4

Guaiacol-d4-1
Guaiacol-d₄-1 is the deuterium labeled Guaiacol[1]. Guaiacol, a phenolic compound, inhibits LPS-stimulated COX-2 expression and NF-κB activation[1]. Anti-inflammatory activity[2].

HY-N1380S2

Guaiacol-13C6
Guaiacol-¹³C₆ is the ¹³C labeled Guaiacol[1]. Guaiacol, a phenolic compound, inhibits LPS-stimulated COX-2 expression and NF-κB activation[1]. Anti-inflammatory activity[2].

HY-B0289S

Erdosteine-13C4
Erdosteine-¹³C₄ is a ¹³C-labeled Erdosteine. Erdosteine inhibits lipopolysaccharide (LPS)-induced NF-κB activation[1][2]. Erdosteine has muco-modulatory, anti-bacterial, anti-inflammatory and anti-oxidant effects[3].

HY-32735S

Triptolide-d3
Triptolide-d₃ is the deuterium labeled Triptolide. Triptolide is a diterpenoid triepoxide extracted from the root of Tripterygium wilfordii with immunosuppressive, anti-inflammatory, antiproliferative and antitumour effects. Triptolide is a NF-κB activation inhibitor[1][2][3][4][5][6].

HY-14655S

Sulfasalazine-d4
Sulfasalazine-d₄ is the deuterium labeled Sulfasalazine. Sulfasalazine (NSC 667219) is an anti-rheumatic agent for the research of rheumatoid arthritis and ulcerative colitis. Sulfasalazine can suppress NF-κB activity. Sulfasalazine is a type 1 ferroptosis inducer[1][2][3][4].

HY-15027S

5-Aminosalicylic Acid-D3 hydrochloride
5-Aminosalicylic Acid-d₃ (hydrochloride) is the deuterium labeled 5-Aminosalicylic Acid. 5-Aminosalicylic acid (Mesalamine) hydrochloride acts as a specific PPARγ agonist and also inhibits p21-activated kinase 1 (PAK1) and NF-κB.

HY-15027S1

5-Aminosalicylic acid-d3
5-Aminosalicylic acid-d₃ is the deuterium labeled 5-Aminosalicylic Acid. 5-Aminosalicylic acid (Mesalamine) acts as a specific PPARγ agonist and also inhibits p21-activated kinase 1 (PAK1) and NF-κB[1][2][3][4].

HY-N0005S

Curcumin-d6
Curcumin-d₆is a deuterium labeled Curcumin (Turmeric yellow). Curcumin (Turmeric yellow) is a natural phenolic compound with diverse pharmacologic effects including anti-inflammatory, antioxidant, antiproliferative and antiangiogenic activities. Curcumin is an inhibitor of p300 histone acetylatransferase (HATs) and also shows inhibitory effects on NF-κB and MAPKs.

HY-15027S2

5-Aminosalicylic acid-13C6
5-Aminosalicylic acid-¹³C₆ is the ¹³C labeled 5-Aminosalicylic Acid[1]. 5-Aminosalicylic acid (Mesalamine) acts as a specific PPARγ agonist and also inhibits p21-activated kinase 1 (PAK1) and NF-κB[2][3][4].

HY-N0001S

(±)-Epicatechin-13C3
(±)-Epicatechin-¹³C₃ is the ¹³C labeled (±)-Epicatechin. (-)-Epicatechin (HY-N0001) inhibits cyclooxygenase-1 (COX-1) with an IC50 of 3.2 μM. (-)-Epicatechin inhibits the IL-1β-induced expression of iNOS by blocking the nuclear localization of the p65 subunit of NF-κB[1].

HY-137315S

TML-6-d3
TML-6-d₃ is the deuterium labeled TML-6. TML-6, an orally active curcumin derivative, inhibits the synthesis of the β-amyloid precursor protein and β-amyloid (Aβ). TML-6 can upregulate Apo E, suppress NF-κB and mTOR, and increase the activity of the anti-

HY-B0808S1

Oxaprozin-d5
Oxaprozin-d₅ is deuterium labeled Oxaprozin. Oxaprozin is an inhibitor of both COX-1 and COX-2 with IC50s of 2.2 μM and 36 μM for human platelet COX-1 and IL-1-stimulated human synovial cell COX-2, respectively. Oxaprozin also inhibits the activation of NF-κB.

HY-10227S

Bortezomib-d8
Bortezomib-d₈ is the deuterium labeled Bortezomib. Bortezomib (PS-341) is a reversible and selective proteasome inhibitor, and potently inhibits 20S proteasome (Ki=0.6 nM) by targeting a threonine residue. Bortezomib disrupts the cell cycle, induces apoptosis, and inhibits NF-κB. Bortezomib is the first proteasome inhibitor anticancer agent. Anti-cancer activity[1][2].

HY-B0185AS

Lidocaine-d10 hydrochloride

Lidocaine-d₁₀ (hydrochloride) is the deuterium labeled Lidocaine hydrochloride. Lidocaine hydrochloride (Lignocaine hydrochloride) inhibits sodium channels involving complex voltage and using dependence[1]. Lidocaine hydrochloride decreases growth, migration and invasion of gastric carcinoma cells via up-regulating miR-145 expression and further inactivation of MEK/ERK and NF-κB signaling pathways. Lidocaine hydrochloride, an amide derivative, has the potential for the research of the ventricular arrhythmia[2].

HY-B0185S1

Lidocaine-d10

Lidocaine-d₁₀ is the deuterium labeled Lidocaine. Lidocaine (Lignocaine) inhibits sodium channels involving complex voltage and using dependence[1]. Lidocaine decreases growth, migration and invasion of gastric carcinoma cells via up-regulating miR-145 expression and further inactivation of MEK/ERK and NF-κB signaling pathways. Lidocaine is an amide derivative and has potential for the research of ventricular arrhythmia[2].

HY-B0185AS1

Lidocaine-d6 hydrochloride

Lidocaine-d₆ (hydrochloride) is deuterium labeled Lidocaine (hydrochloride). Lidocaine hydrochloride (Lignocaine hydrochloride) inhibits sodium channels involving complex voltage and using dependence[1]. Lidocaine hydrochloride decreases growth, migration and invasion of gastric carcinoma cells via up-regulating miR-145 expression and further inactivation of MEK/ERK and NF-κB signaling pathways. Lidocaine hydrochloride is an amide derivative and a agent to treat ventricular arrhythmia and an effective tumor-inhibitor[2].

HY-B0185S

Lidocaine-d10 N-Oxide

N-Oxide Lidocaine-d₁₀ is the deuterium labeled Lidocaine. Lidocaine (Lignocaine) inhibits sodium channels involving complex voltage and using dependence[1]. Lidocaine decreases growth, migration and invasion of gastric carcinoma cells via up-regulating miR-145 expression and further inactivation of MEK/ERK and NF-κB signaling pathways. Lidocaine is an amide derivative and has potential for the research of ventricular arrhythmia[2].

HY-W018772S15

D-Ribose(mixture of isomers)-13c5
D-Ribose(mixture of isomers)-¹³C₅ isomers)-¹³C₅ is the ¹³C labeled D-Ribose(mixture of isomers)[1]. D-Ribose(mixture of isomers) is an energy enhancer, and acts as a sugar moiety of ATP, and widely used as a metabolic therapy supplement for

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