Search Result

Results for "

NK receptor

" in MCE Product Catalog:

By Targets:	Neurokinin Receptor (95) Apoptosis (5) Autophagy (5) Checkpoint Kinase (Chk) (1) Cytochrome P450 (1) Drug Metabolite (2) Endogenous Metabolite (3) HCV (1) HMG-CoA Reductase (HMGCR) (5) IFNAR (2) Interleukin Related (1) Isotope-Labeled Compounds (1) Mitophagy (5) Neurotensin Receptor (1) Toll-like Receptor (TLR) (1)
By Research Areas:	Cancer (20) Cardiovascular Disease (4) Endocrinology (43) Infection (2) Inflammation/Immunology (10) Metabolic Disease (6) Neurological Disease (84)

105

Inhibitors & Agonists

Peptides

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Targets Recommended: Neurokinin Receptor

Cat. No.	Product Name	Target	Research Areas

HY-145250

*NK1 receptor* antagonist 2**	Neurokinin Receptor	Neurological Disease
NK1 receptor antagonist 2 is a NK1 receptor antagonist. NK1 receptor antagonist 2 can be used for the research of tinnitus and hearing loss.

HY-P4032

HCV Peptide (35-44)	HCV	Inflammation/Immunology
HCV Peptide (35-44), a HCV core protein at positions 35 to 44, is a HLA-A2-restricted CTL epitope. HCV Peptide (35-44) inhibits NK cell activity via two distinct mechanisms, directly via KIR2DL2/3, and synergistically via the CD94:NKG2A receptor.

HY-P1276A

Men 10376 TFA Neurokinin-2 receptor antagonist TFA	Neurokinin Receptor	Endocrinology
Men 10376 TFA is a selective tachykinin NK-2 receptor antagonist, with a K_i of 4.4 μM for rat small intestine NK-2 receptor.

HY-151413

MEN 10207	Neurokinin Receptor	Neurological Disease
MEN 10207 is a selective NK-2 tachykinin receptor (Neurokinin Receptor)?antagonist. MEN 10207 has pA₂ values of 5.2, 7.9 and 4.9 in three monoreceptor in vitro assays for NK-1, NK-2 and NK-3 tachykinin receptors, respectively.

HY-P1276

Men 10376 Neurokinin-2 receptor antagonist	Neurokinin Receptor	Endocrinology
Men 10376 is a selective tachykinin NK-2 receptor antagonist, with a K_i of 4.4 μM for rat small intestine NK-2 receptor.

HY-101249

L-732138	Neurokinin Receptor	Cancer Neurological Disease
L-732138 is a selective, potent and competitive neurokinin-1 (NK-1) receptor antagonist with an IC₅₀ of 2.3 nM. L-732138 has 200-fold more potent in cloned human NK-1 receptors than cloned rat NK-1 receptors, and has > 1000-fold more potent than human NK-2 and NK-3 receptors. L-732138 can reduce hyperalgesia and has antitumor action.

HY-P0201A

Substance P TFA Neurokinin P TFA	Neurokinin Receptor Endogenous Metabolite	Endocrinology Neurological Disease Cancer
Substance P TFA (Neurokinin P TFA) is a neuropeptide, acting as a neurotransmitter and as a neuromodulator in the CNS. The endogenous receptor for substance P is neurokinin 1 receptor (NK1-receptor, *NK1R*).

HY-P3802

[D-Trp2,7,9] Substance P	Neurokinin Receptor	Neurological Disease
[D-Trp2,7,9] Substance P is a tachykinin (Neurokinin Receptor) antagonist with K_i values of 1 μM, 1.3 μM, and ~9 μM for *NK-1, NK-2*,and *NK-3* receptor, respectively.

HY-P0201

Substance P Neurokinin P	Neurokinin Receptor Endogenous Metabolite	Neurological Disease Endocrinology Cancer
Substance P (Neurokinin P) is a neuropeptide, acting as a neurotransmitter and as a neuromodulator in the CNS. The endogenous receptor for substance P is neurokinin 1 receptor (NK1-receptor, *NK1R*).

HY-P2546

Biotin-Substance P	Neurokinin Receptor	Neurological Disease
Biotin-Substance P is the biotin tagged Substance P. Substance P (Neurokinin P) is a neuropeptide, acting as a neurotransmitter and as a neuromodulator in the CNS. The endogenous receptor for substance P is neurokinin 1 receptor (NK1-receptor, NK1R).

HY-P1277

GR 94800	Neurokinin Receptor	Neurological Disease
GR 94800 is a potent and selective *NK₂* receptor peptide antagonist, with pK_B values of 9.6, 6.4 and 6.0 for NK₂, NK₁ and NK₃ receptors, respectively.

HY-P3854

GR 83074	Neurokinin Receptor	Neurological Disease
GR 83074 is a potent and selective *NK-2* (Neurokinin Receptor) antagonist with a pK_B of 8.23. GR 83074 is inactive as an NK-3 antagonist and exhibits a 340-fold NK-2/NK-1 selectivity.

HY-P1277A

GR 94800 TFA	Neurokinin Receptor	Neurological Disease
GR 94800 TFA is a potent and selective *NK₂* receptor peptide antagonist, with pK_B values of 9.6, 6.4 and 6.0 for NK₂, NK₁ and NK₃ receptors, respectively.

HY-106659

SCH 900978 NK-1 Antagonist 1	Neurokinin Receptor	Neurological Disease Endocrinology
SCH 900978 (NK-1 Antagonist 1) is an antagonist of NK-1 receptor, used in the research of NK-1 related diseases and conditions such as cough, overactive bladder, alcohol dependency and depression.

HY-12114

Serlopitant
VPD-737; MK-0594
Neurokinin Receptor Neurological Disease Endocrinology

Serlopitant is a selective Neurokinin-1 (NK-1) receptor antagonist.
HY-P0006

Eledoisin
Eledone peptide
Neurokinin Receptor Others

Eledoisin (Eledone peptide) is a specific agonist of NK2 and NK3 receptors.

Serlopitant VPD-737; MK-0594	Neurokinin Receptor	Neurological Disease Endocrinology
Serlopitant is a selective Neurokinin-1 (NK-1) receptor antagonist.

Eledoisin Eledone peptide	Neurokinin Receptor	Others
Eledoisin (Eledone peptide) is a specific agonist of *NK2* and *NK3* receptors.

HY-P3862

[MePhe7]-Neurokinin B	Neurokinin Receptor	Endocrinology Neurological Disease
[MePhe7]-Neurokinin B is an neurokinin NK-3 receptor (NK3R) agonist with an IC₅₀ value of 3 nM. [MePhe7]-Neurokinin B is a potential regulator of pulsatile gonadotropin-releasing hormone (GnRH) secretion via activation of the neurokinin-3 receptor (NK3R).

HY-P1030

Hemokinin 1 (mouse)	Neurokinin Receptor	Endocrinology
Hemokinin 1 (mouse) is a selective agonist of neurokinin-1 receptor, with K_i of 0.175 nM and 560 nM for human NK1 receptor and human NK2 receptor, respectively.

HY-P1738

[Sar9] Substance P
Neurokinin Receptor Neurological Disease Endocrinology

[Sar9] Substance P is a potent and selective neurokinin (NK)-1 receptor agonist.

[Sar9] Substance P	Neurokinin Receptor	Neurological Disease Endocrinology
[Sar9] Substance P is a potent and selective neurokinin (NK)-1 receptor agonist.

HY-12142

Vofopitant GR 205171	Neurokinin Receptor	Neurological Disease Endocrinology
Vofopitant is potent tachykinin NK₁ receptor antagonist, with pK_is of 10.6, 9.5, and 9.8 for human, rat and ferret NK₁ receptor, respectively.

HY-P0242

Neurokinin B	Neurokinin Receptor	Neurological Disease Endocrinology
Neurokinin B belongs to the tachykinin family of peptides. Neurokinin B binds a family of GPCRs-including neurokinin receptor 1 (NK1R), NK2R, and NK3R-to mediate their biological effect.

HY-P1278A

GR 64349 TFA	Neurokinin Receptor	Neurological Disease
GR 64349 is a potent and highly selective *NK₂* receptor peptide antagonist, with an EC₅₀ of 3.7 nM in rat colon. GR 64349 exhibits selectivity >1000 and >300-fold with respect to NK₁ and NK₃ receptors, respectively.

HY-P1278

GR 64349	Neurokinin Receptor	Neurological Disease
GR 64349 is a potent and highly selective *NK₂* receptor peptide antagonist, with an EC₅₀ of 3.7 nM in rat colon. GR 64349 exhibits selectivity >1000 and >300-fold with respect to NK₁ and NK₃ receptors, respectively.

HY-P1198

Hemokinin 1, human	Neurokinin Receptor	Neurological Disease
Hemokinin 1, human is a selective tachykinin neurokinin 1 (NK1) receptor full agonist. Hemokinin 1, human is a full agonist at *NK2* and *NK3* receptor. Hemokinin 1, human can produces an opioid-independent analgesia.

HY-P3851

(β-Ala8)-Neurokinin A (4-10)	Neurokinin Receptor	Neurological Disease
(β-Ala8)-Neurokinin A (4-10), a neuropeptide, is a potent and selective NK-2 tachykinin receptor (Neurokinin Receptor) agonist.

HY-P0242A

Neurokinin B TFA	Neurokinin Receptor	Neurological Disease Endocrinology
Neurokinin B TFA belongs to the tachykinin family of peptides. Neurokinin B binds a family of GPCRs-including neurokinin receptor 1 (NK1R), NK2R, and NK3R-to mediate their biological effect.

HY-P1192

GR-73632	Neurokinin Receptor	Neurological Disease Endocrinology
GR-73632 is a novel tachykinin neurokinin 1 (NK-1) receptor agonist. GR-73632 acts directly on the peripheral terminals of primary sensory neurons through NK1 receptor which convey itch signals.

HY-P1198A

Hemokinin 1, human TFA	Neurokinin Receptor	Neurological Disease
Hemokinin 1, human TFA is a selective tachykinin neurokinin 1 (NK1) receptor full agonist. Hemokinin 1, human TFA is a full agonist at *NK2* and *NK3* receptor. Hemokinin 1, human TFA can produces an opioid-independent analgesia.

HY-106910

Saredutant
SR 48968; SR 48968C
Neurokinin Receptor Neurological Disease Endocrinology

Saredutant is a selective NK2 receptor antagonist.
HY-P0187

Senktide
Neurokinin Receptor Neurological Disease Endocrinology

Senktide is a tachykinin NK₃ receptor agonist.

Saredutant SR 48968; SR 48968C	Neurokinin Receptor	Neurological Disease Endocrinology
Saredutant is a selective NK2 receptor antagonist.

Senktide	Neurokinin Receptor	Neurological Disease Endocrinology
Senktide is a tachykinin **NK₃ receptor** agonist.

HY-108480

SDZ NKT 343	Neurokinin Receptor	Neurological Disease
SDZ NKT 343 is a selective, orally active **NK₁ receptor antagonist with an IC₅₀** of 0.62 nM against human NK₁ receptor. SDZ NKT 343 has good analgesic activity.

HY-P3890

Substance P (5-11)	Neurokinin Receptor	Neurological Disease
Substance P (5-11), the C-terminal heptapeptide of Substance P (Substance P (HY-P0201)), is a neuropeptide. Substance P (5-11) binds to NK-1 tachykinin receptor.

HY-12143

Vofopitant dihydrochloride GR 205171A	Neurokinin Receptor	Cancer Neurological Disease Endocrinology
Vofopitant dihydrochloride (GR 205171A) is a potent, selective and orally available tachykinin neurokinin 1(NK1) receptor antagonist, inhibits [³H]SP binding to the NK1 receptor with pK_i values of 9.5 and 10.6 in rat and human membranes respectively, acts as a potential broad-spectrum anti-emetic agent.

HY-P2475

[Pro9]-Substance P
Neurokinin Receptor Neurological Disease

[Pro9]-Substance P is a potent, reversible and selective agonist of NK-1 tachykinin receptors with an EC₅₀ of 0.93 nM.
HY-P0236

Neurokinin A(4-10)
Neurokinin Receptor Neurological Disease Endocrinology

Neurokinin A (4-10) is a tachykinin NK₂ receptor agonist.
HY-109147A

Imnopitant dihydrochloride
Neurokinin Receptor Neurological Disease

Imnopitant dihydrochloride is a neurokinin NK1 receptor antagonist.

[Pro9]-Substance P	Neurokinin Receptor	Neurological Disease
[Pro9]-Substance P is a potent, reversible and selective agonist of *NK-1* tachykinin receptors with an EC₅₀ of 0.93 nM.

Neurokinin A(4-10)	Neurokinin Receptor	Neurological Disease Endocrinology
Neurokinin A (4-10) is a tachykinin NK₂ receptor agonist.

Imnopitant dihydrochloride	Neurokinin Receptor	Neurological Disease
Imnopitant dihydrochloride is a neurokinin NK1 receptor antagonist.

HY-108481

L-760735	Neurokinin Receptor	Neurological Disease
L-760735 is a high affinity, selective and orally active NK1 receptor antagonist with an IC₅₀ of 0.19 nM for human NK1 receptors. L-760735 exhibits anxiolytic and antidepressant-like effects.

HY-14405B

(R)-Casopitant (R)-GW679769	Neurokinin Receptor	Cancer
(R)-Casopitant ((R)-GW679769) is the isomer of Casopitant (HY-14405). Casopitant is a NK(1)-receptor antagonist. Casopitant can be used for the research of chemotherapy-induced nausea and vomiting.

HY-P1194A

Spantide I TFA	Neurokinin Receptor	Inflammation/Immunology
Spantide I TFA, a substance P analog, is a selective **NK₁ receptor antagonist, with K_i** values of 230 nM and 8150 nM for NK₁ and NK₂ receptor, respectively. Spantide I provides an approach to reduce type 1 and enhance the type 2 cytokine IL-10 in the infected cornea, leading to a significant reduction in corneal perforation.

HY-P1194

Spantide I	Neurokinin Receptor	Inflammation/Immunology
Spantide I, a substance P analog, is a selective **NK₁ receptor antagonist, with K_i** values of 230 nM and 8150 nM for NK₁ and NK₂ receptor, respectively. Spantide I provides an approach to reduce type 1 and enhance the type 2 cytokine IL-10 in the infected cornea, leading to a significant reduction in corneal perforation.

HY-P0197

Neurokinin A Substance K; Neurokinin α; Neuromedin L	Neurokinin Receptor	Neurological Disease Endocrinology
Neurokinin A (Substance K), a peptide neurotransmitter of the tachykinin family, acts via the *NK-2* receptor. Neurokinin A acts as a major mediator in human airway and gastrointestinal tissues.

HY-19633

CS-003 Free base	Neurokinin Receptor	Infection Endocrinology
CS-003 Free base (CS-003), a triple tachykinin receptor antagonist, shows high affinities for human (Neurokinin) NK1, NK2 and NK3 receptors with K_i values of 2.3 nM, 0.54 nM and 0.74 nM, respectively. CS-003 Free base (CS-003) has therapeutic efficacy on respiratory diseases associated with neurokinins.

HY-107691

GR 159897	Neurokinin Receptor	Cancer Endocrinology Neurological Disease
GR 159897 is a highly potent, selective, competitive, brain-penetrated non-peptide neurokinin 2 (NK₂) receptor antagonist. GR 159897 has little or no affinity for NK₁ and NK₃ receptors. GR 159897 inhibits binding of [³H]GR100679 to *human NK₂* (hNK₂)-CHO cells and rat colon membranes with pK_i**s of 9.51 and 10, respectively. Antagonizes bronchoconstriction. Anxiolytic-like and anti-tumor effects.

HY-P1722

Spantide II	Neurokinin Receptor	Inflammation/Immunology
Spantide II, an undecapeptide substance P (SP) analog, is a potent neurokinin-1 receptor (NK-1R) antagonist. Spantide II binds with NK-1R and blocks proinflammatory activities associated with SP. Spantide II can be used in the research of inflammatory skin disorders, such as psoriasis and contact dermatitis.

HY-105436

FR 113680
Neurokinin Receptor Neurological Disease

FR 113680 is a tripeptide substance P antagonist that interacts selectively with the NK₁ neurokinin receptor.
HY-109147

Imnopitant
Neurokinin Receptor Endocrinology Neurological Disease

Imnopitant is a NK1 receptor antagonist (WO2020132716, compound 1) .
HY-P0061

Vapreotide
RC160; BMY 41606
Neurokinin Receptor Cancer

Vapreotide is a neurokinin-1 (NK1) receptor antagonist, with an IC₅₀ of 330 nM.

FR 113680	Neurokinin Receptor	Neurological Disease
FR 113680 is a tripeptide substance P antagonist that interacts selectively with the NK₁ neurokinin receptor.

Imnopitant	Neurokinin Receptor	Endocrinology Neurological Disease
Imnopitant is a NK1 receptor antagonist (WO2020132716, compound 1) .

HY-P0197A

Neurokinin A TFA Substance K TFA; Neurokinin α TFA; Neuromedin L TFA	Neurokinin Receptor	Endocrinology Neurological Disease
Neurokinin A TFA (Substance K TFA), a peptide neurotransmitter of the tachykinin family, acts via the *NK-2* receptor. Neurokinin A acts as a major mediator in human airway and gastrointestinal tissues.

HY-P0236A

Neurokinin A(4-10) TFA
Neurokinin Receptor Neurological Disease Endocrinology

Neurokinin A (4-10) TFA is a tachykinin NK₂ receptor agonist.

HY-G0012

Netupitant metabolite Monohydroxy Netupitant Monohydroxy Netupitant	Neurokinin Receptor Drug Metabolite	Endocrinology
Monohydroxy Netupitant is the metabolite of Netupitant, which is a highly selective NK1 receptor antagonist.

HY-U00207

MEN11467
Neurokinin Receptor Neurological Disease Endocrinology

MEN11467 is a selective and orally- effective peptidomimetic tachykinin NK₁ receptor antagonist.

HY-17615

Fosnetupitant Pronetupitant	Neurokinin Receptor	Neurological Disease
Fosnetupitant (Pronetupitant) a methylene phosphate proagent of Netupitant. Fosnetupitant (Pronetupitant) exhibits a pK_i of 9.5 for human NK₁ receptor.

HY-14770

Ibodutant
MEN 15596
Neurokinin Receptor Neurological Disease Endocrinology

Ibodutant (MEN 15596) is a potent and selective tachykinin NK2 receptor antagonist with a pK_i of 10.1.

HY-G0011

Netupitant metabolite Netupitant N-oxide Netupitant N-oxide	Drug Metabolite	Neurological Disease Endocrinology
Netupitant N-oxide is the metabolite of Netupitant, which is a highly selective NK1 receptor antagonist.

HY-19670

Befetupitant
Ro67-5930
Neurokinin Receptor Neurological Disease Endocrinology

Befetupitant is a high-affinity, nonpeptide, competitive tachykinin 1 receptor (NK1R) antagonist.
HY-14432

Pavinetant
MLE-4901; AZD2624; AZD4901
Neurokinin Receptor Neurological Disease Endocrinology

Pavinetant (MLE-4901) is a neurokinin-3 receptor (NK3R) antagonist.

HY-18006

NKP608	Neurokinin Receptor	Neurological Disease Endocrinology
NKP608 is a non-peptidic derivative of 4-aminopiperidine which acts as a selective, specific and potent antagonist at the neurokinin-1 (NK-1) receptor both in vitro(IC50=2.6 nM) and in vivo.

HY-15722

SB-222200	Neurokinin Receptor	Neurological Disease Endocrinology
SB-222200 is a potent, selective, orally active and blood-brain barrier (BBB) penetrant NK-3 receptor antagonist. SB-222200 is developed for central nervous system (CNS) disorders.

HY-P3852

*Neurokinin Receptor* (393-407), rat** SPR393-407	Neurokinin Receptor	Inflammation/Immunology Neurological Disease
Neurokinin Receptor (393-407), rat (SPR393–407) is a rat *neurokinin 1 receptor* (NK1R)** fragment. NK1R is rapidly internalized by endocytosis and recycled to the plasma membrane when binding to substance P (SP). Neurokinin Receptor (393-407), rat can be used in the research of neurogenic inflammation.

HY-19632

Fezolinetant
ESN-364
Neurokinin Receptor Endocrinology

Fezolinetant is an antagonist of the neurokinin 3 receptor (NK3R), used for the treatment of menopausal hot flushes.

HY-B0144S

Pitavastatin-d4 hemicalcium NK-104-d₄ (hemicalcium); Pitavastatin-d₄ (hemicalcium)	HMG-CoA Reductase (HMGCR) Autophagy Mitophagy Apoptosis	Metabolic Disease Cancer
Pitavastatin-d₄ (hemicalcium) is deuterium labeled Pitavastatin (Calcium). Pitavastatin Calcium (NK-104 hemicalcium) is a potent hydroxymethylglutaryl-CoA (HMG-CoA) reductase inhibitor. Pitavastatin Calcium (NK-104 hemicalcium) inhibits cholesterol synthesis from acetic acid with an IC50 of 5.8 nM in HepG2 cells. Pitavastatin Calcium is an efficient hepatocyte low-density lipoprotein-cholesterol (LDL-C) receptor inducer. Anti-cancer activity[1][2][3].

HY-P3861

Biotin-NeurokininA	Neurokinin Receptor	Neurological Disease
Biotin-NeurokininA is a biotinylated NeurokininA (HY-P0197). Neurokinin A (Substance K), a peptide neurotransmitter of the tachykinin family, acts via the NK-2 receptor. Neurokinin A acts as a major mediator in human airway and gastrointestinal tissues.

HY-P0255

Physalaemin
Neurokinin Receptor Neurological Disease Endocrinology

Physalaemin, a non-mammalian tachykinin, binds selectively to neurokinin-1 (NK1) receptor with high affinity.

HY-B0144

Pitavastatin Calcium NK-104 hemicalcium; Pitavastatin hemicalcium	HMG-CoA Reductase (HMGCR) Autophagy Mitophagy Apoptosis	Cancer Metabolic Disease Neurological Disease Cardiovascular Disease
Pitavastatin Calcium (NK-104 hemicalcium) is a potent hydroxymethylglutaryl-CoA (HMG-CoA) reductase inhibitor. Pitavastatin Calcium (NK-104 hemicalcium) inhibits cholesterol synthesis from acetic acid with an IC₅₀ of 5.8 nM in HepG2 cells. Pitavastatin Calcium is an efficient hepatocyte low-density lipoprotein-cholesterol (LDL-C) receptor inducer. Pitavastatin Calcium also possesses anti-atherosclerotic, anti-asthmatic, anti-osteoarthritis, antineoplastic, neuroprotective, hepatoprotective and reno-protective effects.

HY-122347A

Orvepitant maleate GW823296 maleate	Neurokinin Receptor	Neurological Disease
Orvepitant maleate (GW823296 maleate) is potent, selective, orally active and well-tolerated neurokinin-1 receptor (NK-1) antagonist with a pK_i of 10.2 for human neurokinin-1 receptor. Orvepitant maleate can across the blood-brain barrier. Orvepitant maleate has the potential for depressive disorder and chronic refractory cough (CRC) treatment.

HY-P1031

[bAla8]-Neurokinin A(4-10)
MEN 10210
Neurokinin Receptor Endocrinology

[bAla8]-Neurokinin A(4-10) is a neurokinin 2 (NK2) receptor agonist.

HY-P1017

MDL 29913	Neurokinin Receptor	Neurological Disease Cardiovascular Disease
MDL 29913, a cyclic pseudopeptide, is a competitive *NK₂* tachykinin receptor selective antagonist, with a pA₂ of 8.66.

HY-P0061A

Vapreotide acetate RC-160 acetate; BMY-41606 acetate	Neurokinin Receptor	Cancer
Vapreotide acetate (RC-160 acetate; BMY-41606 acetate) is a neurokinin-1 (NK1) receptor antagonist, with an IC₅₀ of 330 nM.

HY-107692

SB 218795	Neurokinin Receptor	Neurological Disease
SB 218795 is a potent and selective non-peptide NK3 receptor antagonist, with a K_i 13 nM for hNK3. SB 218795 shows about 90-fold and 7000-fold selectivity for hNK3 over hNK2 and hNK1, respectively. SB 218795 can inhibit NK3 receptor-mediated pupillary constriction of the rabbit.

HY-P3889

Substance P (6-11)	Neurokinin Receptor	Neurological Disease
Substance P (6-11) is the C-terminal hexapeptideamide of Substance P (Substance P (HY-P0201)). Substance P (6-11) binds to NK-1 tachykinin receptor. Substance P (6-11) shows depolarization of motoneurons and a hypotensive effect.

HY-14551

Osanetant SR142801	Neurokinin Receptor	Neurological Disease
Osanetant (SR142801) is a selective NK3 receptor antagonist. Osanetant produces anxiolytic- and antidepressant-like effects and is researched for schizophrenia.

HY-P3092

Phyllomedusin	Neurokinin Receptor	Neurological Disease
Phyllomedusin, an tachykinin decapeptide, is a NK1 receptor agonist. Phyllomedusin has vasodilating activity and provokes the contraction of the pylorus.

HY-P1012

[Sar9,Met(O2)11]-Substance P
Neurokinin Receptor Neurological Disease Endocrinology

[Sar9,Met(O2)11]-Substance P is a tachykinin NK₁ receptor selective agonist.
HY-P1012A

[Sar9,Met(O2)11]-Substance P TFA
Neurokinin Receptor Neurological Disease Endocrinology

[Sar9,Met(O2)11]-Substance P TFA is a tachykinin NK₁ receptor selective agonist.

HY-B0144AS1

Pitavastatin-d5 sodium NK-104-d₅ (sodium)	Mitophagy HMG-CoA Reductase (HMGCR) Apoptosis Autophagy	Cancer Metabolic Disease
Pitavastatin-d₅ (sodium) is the deuterium labeled Pitavastatin sodium. Pitavastatin (NK-104) is a potent hydroxymethylglutaryl-CoA (HMG-CoA) reductase inhibitor. Pitavastatin inhibits cholesterol synthesis from acetic acid with an IC50 of 5.8 nM in HepG2 cells. Pitavastatin is an efficient hepatocyte low-density lipoprotein-cholesterol (LDL-C) receptor inducer. Anti-cancer activity.

HY-P3891

Substance P (4-11)	Neurokinin Receptor	Neurological Disease
Substance P (4-11), the C-terminus fragment of Substance P (Substance P (HY-P0201)), is a Substance P agonist that shows highly selective for NK1 receptors.

HY-14551B

(S)-Osanetant (S)-SR142801	Neurotensin Receptor	Neurological Disease
(S)-Osanetant is the S-enantiomer of Osanetant. Osanetant (SR142801) is a selective NK3 receptor antagonist. Osanetant produces anxiolytic- and antidepressant-like effects and is researched for schizophrenia.

HY-P2000

Septide
(Pyr6,Pro9)-Substance P
Neurokinin Receptor Neurological Disease

Septide ((Pyr6,Pro9)-Substance P) is a potent NK1 receptor agonist with a K_d value of 0.55 nM.

HY-108479

Nolpitantium SR140333	Neurokinin Receptor	Neurological Disease
Nolpitantium (SR140333) is a potent, selective, competitive, non-peptide tachykinin **NK₁ receptor** antagonist. Nolpitantium blocks the activation of rat thalamic neurons after nociceptive stimulation.

HY-118463

Benzomalvin A	Neurokinin Receptor	Neurological Disease
Benzomalvin A is a potent antagonist of neurokinin receptor isolated from Penicillium sp. Benzomalvin A shows inhibitory activity against substance P with K_i values of 12, 42 and 43 μM at the guinea pig, rat and human neurokinin NK1 receptors, respectively.

HY-16346S

Netupitant-d6 CID-6451149-d₆	Neurokinin Receptor	Endocrinology Neurological Disease
Netupitant-d₆ is the deuterium labeled Netupitant (CID-6451149), which is a highly potent and selective, orally active neurokinin-1 (NK1) receptor antagonist[1].

HY-B0144A

Pitavastatin NK-104	HMG-CoA Reductase (HMGCR) Autophagy Mitophagy Apoptosis	Cancer Metabolic Disease Neurological Disease Cardiovascular Disease
Pitavastatin (NK-104) is a potent hydroxymethylglutaryl-CoA (HMG-CoA) reductase inhibitor. Pitavastatin inhibits cholesterol synthesis from acetic acid with an IC₅₀ of 5.8 nM in HepG2 cells. Pitavastatin is an efficient hepatocyte low-density lipoprotein-cholesterol (LDL-C) receptor inducer. Pitavastatin also possesses anti-atherosclerotic, anti-asthmatic, anti-osteoarthritis, antineoplastic, neuroprotective, hepatoprotective and reno-protective effects.

HY-B0144B

Pitavastatin sodium NK-104 sodium	HMG-CoA Reductase (HMGCR) Autophagy Mitophagy Apoptosis	Cancer Metabolic Disease Neurological Disease Cardiovascular Disease
Pitavastatin (NK-104) sodium is a potent hydroxymethylglutaryl-CoA (HMG-CoA) reductase inhibitor. Pitavastatin sodium inhibits cholesterol synthesis from acetic acid with an IC₅₀ of 5.8 nM in HepG2 cells. Pitavastatin sodium is an efficient hepatocyte low-density lipoprotein-cholesterol (LDL-C) receptor inducer. Pitavastatin sodium also possesses anti-atherosclerotic, anti-asthmatic, anti-osteoarthritis, antineoplastic, neuroprotective, hepatoprotective and reno-protective effects.

HY-P3853

GR 87389	Neurokinin Receptor	Neurological Disease
GR 87389 is a potent NK2 receptor antagonist. GR 87389 antagonized GA 64349-induced smooth muscle strips contractions in a competitive manner in the human detrusor, prostate and prostatic urethra.

HY-P3849

[Lys5,MeLeu9,Nle10]Neurokinin A(4-10) LMN-NKA	Neurokinin Receptor	Neurological Disease
[Lys5,MeLeu9,Nle10]Neurokinin A(4-10) (LMN-NKA), an analogue of Neurokinin A, is a selective and potent *NK2R* agonist. [Lys5,MeLeu9,Nle10]Neurokinin A(4-10) has prokinetic activity. [Lys5,MeLeu9,Nle10]Neurokinin A(4-10) can be used to study the roles of the NK-2 receptor in smooth muscle contraction in numerous tissues.

HY-P1279

[Lys5,MeLeu9,Nle10]-NKA(4-10)
Neurokinin Receptor Inflammation/Immunology

[Lys5,MeLeu9,Nle10]-NKA(4-10) is a highly selective and potent NK₂ receptor agonist, with an IC₅₀ of 6.1 nM.
HY-P3881

(D-Arg1,D-Pro2,D-Phe7,D-His9)-Substance P
Neurokinin Receptor Neurological Disease

(D-Arg1,D-Pro2,D-Phe7,D-His9)-Substance P is a selective NK₁ receptor antagonist.

HY-10053

Maropitant	Neurokinin Receptor	Neurological Disease Endocrinology
Maropitant is a selective and orally active neurokinin (NK1) receptor antagonist. Maropitant acts by blocking the binding of substance P within the emetic center and the chemoreceptor trigger zone (CRTZ). Maropitant is highly effective in preventing vomiting.

HY-14406A

L-733060 hydrochloride	Neurokinin Receptor	Cancer Neurological Disease
L-733060 hydrochloride is a potent tachykinin **NK₁ receptor** antagonist. L-733060 hydrochloride inhibits neurogenic plasma extravasation at doses that do not cause adverse cardiovascular effects in rodents and also acts as an antitumoral agent.

HY-16346

Netupitant CID 6451149	Neurokinin Receptor	Neurological Disease Endocrinology
Netupitant (CID-6451149) is a highly potent, selective and orally active neurokinin-1 (NK₁) receptor antagonist with a K_i of 0.95 nM for hNK₁ in CHO cells. Netupitant has antiemetic affect.

HY-P1279A

[Lys5,MeLeu9,Nle10]-NKA(4-10) TFA	Neurokinin Receptor	Neurological Disease
[Lys5,MeLeu9,Nle10]-NKA(4-10) TFA is a highly selective and potent *NK₂* receptor agonist, with an IC₅₀ of 6.1 nM.

HY-119552

Acetylaszonalenin LL-S490β	Endogenous Metabolite Neurokinin Receptor	Neurological Disease
Acetylaszonalenin, a prenylated indole derivative, is a fungal metabolite.Acetylaszonalenin is a potent neurokinin-1 (NK1) receptor antagonist. Acetylaszonalenin shows inhibition of [³H]-SP binding to human astrocytoma cells with a K_i of 170 μM.

HY-B2078A

Eprazinone dihydrochloride	Neurokinin Receptor	Inflammation/Immunology
Eprazinone dihydrochloride is a gent with mucolytic, secretolytic, antitussive, and bronchial antispasmodic properties. Eprazinone dihydrochloride is a neurokinin 1 receptor (NK1R) ligand. Eprazinone dihydrochloride has the potential for chronic bronchitis treatment that improved pulmonary function and arterial partial pressure of oxygen.

HY-14751A

Rolapitant hydrochloride SCH619734 hydrochloride	Neurokinin Receptor	Neurological Disease
Rolapitant (SCH619734) hydrochloride is a potent, selective, long-acting and orally active neurokinin 1 (NK1) receptor antagonist with a K_i of 0.66 nM. Rolapitant hydrochloride does not interact with CYP3A4. Rolapitant hydrochloride shows potent anti-emetic activity in a ferret emesis model.

HY-16436

Rolapitant hydrochloride hydrate SCH619734 hydrochloride hydrate	Neurokinin Receptor	Cancer Neurological Disease
Rolapitant hydrochloride hydrate (SCH619734 hydrochloride hydrate) is a potent, selective, long-acting and orally active neurokinin 1 (NK1) receptor antagonist with a K_i of 0.66 nM. Rolapitant hydrochloride hydrate does not interact with CYP3A4. Rolapitant hydrochloride hydrate shows potent anti-emetic activity in a ferret emesis model.

HY-14751

Rolapitant SCH619734	Neurokinin Receptor	Cancer Neurological Disease
Rolapitant (SCH619734) is a potent, selective, long-acting and orally active neurokinin 1 (NK1) receptor antagonist with a K_i of 0.66 nM. Rolapitant does not interact with CYP3A4. Rolapitant shows potent anti-emetic activity in a ferret emesis model.

HY-14552

Talnetant SB 223412	Neurokinin Receptor	Neurological Disease Endocrinology
Talnetant (SB 223412) is a selective, competitive, brain-permeable *NK3* receptor antagonist with a K_i of 1.4 nM in hNK-3-CHO cells. Talnetant is 100-fold more selective for hNK-3 relative to the hNK-2 receptor and has no affinity for hNK-1. Talnetant can be used in schizophrenia-related studies.

HY-14552A

Talnetant hydrochloride SB 223412 hydrochloride; SB 223412-A	Neurokinin Receptor	Neurological Disease Endocrinology
Talnetant (SB 223412) hydrochloride is a selective, competitive, brain-permeable *NK3* receptor antagonist with a K_i of 1.4 nM in hNK-3-CHO cells. Talnetant hydrochloride is 100-fold more selective for hNK-3 relative to the hNK-2 receptor and has no affinity for hNK-1. Talnetant hydrochloride can be used in schizophrenia-related studies.

HY-P3069

γ-Neuropeptide (rabbit)	Neurokinin Receptor	Endocrinology Neurological Disease
γ-Neuropeptide (rabbit) can be isolated from rabbit intestine. γ-Neuropeptide is an endogenous neurokinin peptide that acts as a neurokinin 2 (NK2) receptor agonist. γ-Neuropeptide mediates hypothalamic-pituitary-adrenal (HPA) axis, as well as reproductive hormone release.

HY-10053S1

Maropitant-13C,d3	Isotope-Labeled Compounds Neurokinin Receptor	Neurological Disease Endocrinology
Maropitant-¹³C,d₃ is the ¹³C- and deuterium labeled Maropitant. Maropitant is a selective and orally active neurokinin (NK1) receptor antagonist. Maropitant acts by blocking the binding of substance P within the emetic center and the chemoreceptor trigger zone (CRTZ). Maropitant is highly effective in preventing vomiting[1][2].

HY-105215

FK888	Neurokinin Receptor	Inflammation/Immunology
FK888 is a potent, selective, and high affinity dipeptide *NK1* receptor antagonist. FK888 displaces [3H]-SP binding with a K_i value of 0.69 nM and 0.45 microM. FK888 also inhibits SP-induced airway oedema in guinea-pig after both intravenous and oral administration.

HY-14405A

Casopitant mesylate GW679769B	Neurokinin Receptor Cytochrome P450	Neurological Disease Cancer
Casopitant mesylate (GW679769B) is a potent, selective, brain permeable and orally active neurokinin 1 (NK1) receptor antagonist. Casopitant mesylate is a second in the class of antiemetics that acts to antagonise the emetogenic effect of substance P. Casopitant mesylate is also a substrate and a weak-to-moderate inhibitor of CYP3A4. Casopitant mesylate can be used for chemotherapy-induced nausea and vomiting (CINV) and postoperative nausea and vomiting (PONV).

HY-150741

ODN 2216	Toll-like Receptor (TLR) IFNAR Interleukin Related	Cancer Infection Inflammation/Immunology
ODN 2216 is a human-specific TLR9 (toll-like receptor 9) ligand or agonist. ODN 2216 induces high amounts of IFN-α and IFN-β. ODN 2216 induces IFN-α by pDC (plasmacytoid DC) and IL-12 (p40) production by DC (dendritic cells). ODN 2216 stimulates IFN-γ production in peripheral blood mononuclear cells (PBMC), which is indirect and mediated by IFN-α/β. ODN 2216 can activate NK cells and promote IFN-γ production of TCR-triggered CD4⁺ T cells.

HY-P3801

[Glp5,(Me)Phe8,Sar9] Substance P (5-11) DiMe-C7	Neurokinin Receptor	Metabolic Disease Neurological Disease Others
[Glp5,(Me)Phe8,Sar9] Substance P (5-11) (DiMe-C7) is a Substance P (HY-P0201) analogue that has approximately the same effects as Substance P (HY-P0201) on neurokinin 1 receptor (NK1R) in rat brain, but with a much longer duration of action. [Glp5,(Me)Phe8,Sar9] Substance P (5-11) selectively activates dopamine metabolism in the mesencephalon and midbrain cortex of the rat brain. [Glp5,(Me)Phe8,Sar9] Substance P (5-11) also increases motor activity and induces recovery of addictive agent-seeking behavior in rats.

HY-P99032

Monalizumab	Checkpoint Kinase (Chk) IFNAR	Cancer Inflammation/Immunology
Monalizumab is a first-in-class immune checkpoint inhibitor targeting Natural Killer Group 2A (NKG2A). Monalizumab, a humanized anti-NKG2A blocking mAb, increases IFN-γ production, thereby promoting NK cell effector functions. Monalizumab can be used for the research of head and neck squamous cell carcinoma (HNSCC).

Cat. No.	Product Name	Target	Research Area

HY-P4032

HCV Peptide (35-44)	HCV	Inflammation/Immunology
HCV Peptide (35-44), a HCV core protein at positions 35 to 44, is a HLA-A2-restricted CTL epitope. HCV Peptide (35-44) inhibits NK cell activity via two distinct mechanisms, directly via KIR2DL2/3, and synergistically via the CD94:NKG2A receptor.

HY-P1276A

Men 10376 TFA Neurokinin-2 receptor antagonist TFA	Neurokinin Receptor	Endocrinology
Men 10376 TFA is a selective tachykinin NK-2 receptor antagonist, with a K_i of 4.4 μM for rat small intestine NK-2 receptor.

HY-151413

MEN 10207	Neurokinin Receptor	Neurological Disease
MEN 10207 is a selective NK-2 tachykinin receptor (Neurokinin Receptor)?antagonist. MEN 10207 has pA₂ values of 5.2, 7.9 and 4.9 in three monoreceptor in vitro assays for NK-1, NK-2 and NK-3 tachykinin receptors, respectively.

HY-P1276

Men 10376 Neurokinin-2 receptor antagonist	Neurokinin Receptor	Endocrinology
Men 10376 is a selective tachykinin NK-2 receptor antagonist, with a K_i of 4.4 μM for rat small intestine NK-2 receptor.

HY-P0201A

Substance P TFA Neurokinin P TFA	Neurokinin Receptor Endogenous Metabolite	Endocrinology Neurological Disease Cancer
Substance P TFA (Neurokinin P TFA) is a neuropeptide, acting as a neurotransmitter and as a neuromodulator in the CNS. The endogenous receptor for substance P is neurokinin 1 receptor (NK1-receptor, *NK1R*).

HY-P3802

[D-Trp2,7,9] Substance P	Neurokinin Receptor	Neurological Disease
[D-Trp2,7,9] Substance P is a tachykinin (Neurokinin Receptor) antagonist with K_i values of 1 μM, 1.3 μM, and ~9 μM for *NK-1, NK-2*,and *NK-3* receptor, respectively.

HY-P0201

Substance P Neurokinin P	Neurokinin Receptor Endogenous Metabolite	Neurological Disease Endocrinology Cancer
Substance P (Neurokinin P) is a neuropeptide, acting as a neurotransmitter and as a neuromodulator in the CNS. The endogenous receptor for substance P is neurokinin 1 receptor (NK1-receptor, *NK1R*).

HY-P2546

Biotin-Substance P	Neurokinin Receptor	Neurological Disease
Biotin-Substance P is the biotin tagged Substance P. Substance P (Neurokinin P) is a neuropeptide, acting as a neurotransmitter and as a neuromodulator in the CNS. The endogenous receptor for substance P is neurokinin 1 receptor (NK1-receptor, NK1R).

HY-P1277

GR 94800	Neurokinin Receptor	Neurological Disease
GR 94800 is a potent and selective *NK₂* receptor peptide antagonist, with pK_B values of 9.6, 6.4 and 6.0 for NK₂, NK₁ and NK₃ receptors, respectively.

HY-P3854

GR 83074	Neurokinin Receptor	Neurological Disease
GR 83074 is a potent and selective *NK-2* (Neurokinin Receptor) antagonist with a pK_B of 8.23. GR 83074 is inactive as an NK-3 antagonist and exhibits a 340-fold NK-2/NK-1 selectivity.

HY-P1277A

GR 94800 TFA	Neurokinin Receptor	Neurological Disease
GR 94800 TFA is a potent and selective *NK₂* receptor peptide antagonist, with pK_B values of 9.6, 6.4 and 6.0 for NK₂, NK₁ and NK₃ receptors, respectively.

HY-P0006

Eledoisin
Eledone peptide
Neurokinin Receptor Others

Eledoisin (Eledone peptide) is a specific agonist of NK2 and NK3 receptors.

HY-P3862

[MePhe7]-Neurokinin B	Neurokinin Receptor	Endocrinology Neurological Disease
[MePhe7]-Neurokinin B is an neurokinin NK-3 receptor (NK3R) agonist with an IC₅₀ value of 3 nM. [MePhe7]-Neurokinin B is a potential regulator of pulsatile gonadotropin-releasing hormone (GnRH) secretion via activation of the neurokinin-3 receptor (NK3R).

HY-P1030

Hemokinin 1 (mouse)	Neurokinin Receptor	Endocrinology
Hemokinin 1 (mouse) is a selective agonist of neurokinin-1 receptor, with K_i of 0.175 nM and 560 nM for human NK1 receptor and human NK2 receptor, respectively.

HY-P1738

[Sar9] Substance P
Neurokinin Receptor Neurological Disease Endocrinology

[Sar9] Substance P is a potent and selective neurokinin (NK)-1 receptor agonist.

HY-P0242

Neurokinin B	Neurokinin Receptor	Neurological Disease Endocrinology
Neurokinin B belongs to the tachykinin family of peptides. Neurokinin B binds a family of GPCRs-including neurokinin receptor 1 (NK1R), NK2R, and NK3R-to mediate their biological effect.

HY-P1278A

GR 64349 TFA	Neurokinin Receptor	Neurological Disease
GR 64349 is a potent and highly selective *NK₂* receptor peptide antagonist, with an EC₅₀ of 3.7 nM in rat colon. GR 64349 exhibits selectivity >1000 and >300-fold with respect to NK₁ and NK₃ receptors, respectively.

HY-P1278

GR 64349	Neurokinin Receptor	Neurological Disease
GR 64349 is a potent and highly selective *NK₂* receptor peptide antagonist, with an EC₅₀ of 3.7 nM in rat colon. GR 64349 exhibits selectivity >1000 and >300-fold with respect to NK₁ and NK₃ receptors, respectively.

HY-P1198

Hemokinin 1, human	Neurokinin Receptor	Neurological Disease
Hemokinin 1, human is a selective tachykinin neurokinin 1 (NK1) receptor full agonist. Hemokinin 1, human is a full agonist at *NK2* and *NK3* receptor. Hemokinin 1, human can produces an opioid-independent analgesia.

HY-P3851

(β-Ala8)-Neurokinin A (4-10)	Neurokinin Receptor	Neurological Disease
(β-Ala8)-Neurokinin A (4-10), a neuropeptide, is a potent and selective NK-2 tachykinin receptor (Neurokinin Receptor) agonist.

HY-P0242A

Neurokinin B TFA	Neurokinin Receptor	Neurological Disease Endocrinology
Neurokinin B TFA belongs to the tachykinin family of peptides. Neurokinin B binds a family of GPCRs-including neurokinin receptor 1 (NK1R), NK2R, and NK3R-to mediate their biological effect.

HY-P1192

GR-73632	Neurokinin Receptor	Neurological Disease Endocrinology
GR-73632 is a novel tachykinin neurokinin 1 (NK-1) receptor agonist. GR-73632 acts directly on the peripheral terminals of primary sensory neurons through NK1 receptor which convey itch signals.

HY-P1198A

Hemokinin 1, human TFA	Neurokinin Receptor	Neurological Disease
Hemokinin 1, human TFA is a selective tachykinin neurokinin 1 (NK1) receptor full agonist. Hemokinin 1, human TFA is a full agonist at *NK2* and *NK3* receptor. Hemokinin 1, human TFA can produces an opioid-independent analgesia.

HY-P0187

Senktide
Neurokinin Receptor Neurological Disease Endocrinology

Senktide is a tachykinin NK₃ receptor agonist.

HY-P3890

Substance P (5-11)	Neurokinin Receptor	Neurological Disease
Substance P (5-11), the C-terminal heptapeptide of Substance P (Substance P (HY-P0201)), is a neuropeptide. Substance P (5-11) binds to NK-1 tachykinin receptor.

HY-P2475

[Pro9]-Substance P
Neurokinin Receptor Neurological Disease

[Pro9]-Substance P is a potent, reversible and selective agonist of NK-1 tachykinin receptors with an EC₅₀ of 0.93 nM.
HY-P0236

Neurokinin A(4-10)
Neurokinin Receptor Neurological Disease Endocrinology

Neurokinin A (4-10) is a tachykinin NK₂ receptor agonist.

HY-P1193

GR 82334	Peptides	Neurological Disease
GR 82334 is a potent and specific reversible tachykinin NK1 receptor antagonist. GR 82334 inhibits substance P-induced sensitization by blocking SP NK1 receptors in naked mole-rats.

HY-P1194A

Spantide I TFA	Neurokinin Receptor	Inflammation/Immunology
Spantide I TFA, a substance P analog, is a selective **NK₁ receptor antagonist, with K_i** values of 230 nM and 8150 nM for NK₁ and NK₂ receptor, respectively. Spantide I provides an approach to reduce type 1 and enhance the type 2 cytokine IL-10 in the infected cornea, leading to a significant reduction in corneal perforation.

HY-P1194

Spantide I	Neurokinin Receptor	Inflammation/Immunology
Spantide I, a substance P analog, is a selective **NK₁ receptor antagonist, with K_i** values of 230 nM and 8150 nM for NK₁ and NK₂ receptor, respectively. Spantide I provides an approach to reduce type 1 and enhance the type 2 cytokine IL-10 in the infected cornea, leading to a significant reduction in corneal perforation.

HY-P0197

Neurokinin A Substance K; Neurokinin α; Neuromedin L	Neurokinin Receptor	Neurological Disease Endocrinology
Neurokinin A (Substance K), a peptide neurotransmitter of the tachykinin family, acts via the *NK-2* receptor. Neurokinin A acts as a major mediator in human airway and gastrointestinal tissues.

HY-P1722

Spantide II	Neurokinin Receptor	Inflammation/Immunology
Spantide II, an undecapeptide substance P (SP) analog, is a potent neurokinin-1 receptor (NK-1R) antagonist. Spantide II binds with NK-1R and blocks proinflammatory activities associated with SP. Spantide II can be used in the research of inflammatory skin disorders, such as psoriasis and contact dermatitis.

HY-105436

FR 113680
Neurokinin Receptor Neurological Disease

FR 113680 is a tripeptide substance P antagonist that interacts selectively with the NK₁ neurokinin receptor.
HY-P0061

Vapreotide
RC160; BMY 41606
Neurokinin Receptor Cancer

Vapreotide is a neurokinin-1 (NK1) receptor antagonist, with an IC₅₀ of 330 nM.

HY-P0197A

Neurokinin A TFA Substance K TFA; Neurokinin α TFA; Neuromedin L TFA	Neurokinin Receptor	Endocrinology Neurological Disease
Neurokinin A TFA (Substance K TFA), a peptide neurotransmitter of the tachykinin family, acts via the *NK-2* receptor. Neurokinin A acts as a major mediator in human airway and gastrointestinal tissues.

HY-P0236A

Neurokinin A(4-10) TFA
Neurokinin Receptor Neurological Disease Endocrinology

Neurokinin A (4-10) TFA is a tachykinin NK₂ receptor agonist.

HY-P3852

*Neurokinin Receptor* (393-407), rat** SPR393-407	Neurokinin Receptor	Inflammation/Immunology Neurological Disease
Neurokinin Receptor (393-407), rat (SPR393–407) is a rat *neurokinin 1 receptor* (NK1R)** fragment. NK1R is rapidly internalized by endocytosis and recycled to the plasma membrane when binding to substance P (SP). Neurokinin Receptor (393-407), rat can be used in the research of neurogenic inflammation.

HY-P3861

Biotin-NeurokininA	Neurokinin Receptor	Neurological Disease
Biotin-NeurokininA is a biotinylated NeurokininA (HY-P0197). Neurokinin A (Substance K), a peptide neurotransmitter of the tachykinin family, acts via the NK-2 receptor. Neurokinin A acts as a major mediator in human airway and gastrointestinal tissues.

HY-P1031

[bAla8]-Neurokinin A(4-10)
MEN 10210
Neurokinin Receptor Endocrinology

[bAla8]-Neurokinin A(4-10) is a neurokinin 2 (NK2) receptor agonist.

HY-P1017

MDL 29913	Neurokinin Receptor	Neurological Disease Cardiovascular Disease
MDL 29913, a cyclic pseudopeptide, is a competitive *NK₂* tachykinin receptor selective antagonist, with a pA₂ of 8.66.

HY-P0061A

Vapreotide acetate RC-160 acetate; BMY-41606 acetate	Neurokinin Receptor	Cancer
Vapreotide acetate (RC-160 acetate; BMY-41606 acetate) is a neurokinin-1 (NK1) receptor antagonist, with an IC₅₀ of 330 nM.

HY-P3889

Substance P (6-11)	Neurokinin Receptor	Neurological Disease
Substance P (6-11) is the C-terminal hexapeptideamide of Substance P (Substance P (HY-P0201)). Substance P (6-11) binds to NK-1 tachykinin receptor. Substance P (6-11) shows depolarization of motoneurons and a hypotensive effect.

HY-P3092

Phyllomedusin	Neurokinin Receptor	Neurological Disease
Phyllomedusin, an tachykinin decapeptide, is a NK1 receptor agonist. Phyllomedusin has vasodilating activity and provokes the contraction of the pylorus.

HY-P1012

[Sar9,Met(O2)11]-Substance P
Neurokinin Receptor Neurological Disease Endocrinology

[Sar9,Met(O2)11]-Substance P is a tachykinin NK₁ receptor selective agonist.
HY-P1012A

[Sar9,Met(O2)11]-Substance P TFA
Neurokinin Receptor Neurological Disease Endocrinology

[Sar9,Met(O2)11]-Substance P TFA is a tachykinin NK₁ receptor selective agonist.

HY-P3891

Substance P (4-11)	Neurokinin Receptor	Neurological Disease
Substance P (4-11), the C-terminus fragment of Substance P (Substance P (HY-P0201)), is a Substance P agonist that shows highly selective for NK1 receptors.

HY-P2000

Septide
(Pyr6,Pro9)-Substance P
Neurokinin Receptor Neurological Disease

Septide ((Pyr6,Pro9)-Substance P) is a potent NK1 receptor agonist with a K_d value of 0.55 nM.

HY-P3598

Substance P(1-4)	Peptides	Cancer
Substance P(1-4) is a potent neurokinin receptors (NK-R) antagonist. Substance P(1-4) has regulation of normal hematopoiesis and inhibits endogenous erythroid colony (EEC) formation.

HY-P3853

GR 87389	Neurokinin Receptor	Neurological Disease
GR 87389 is a potent NK2 receptor antagonist. GR 87389 antagonized GA 64349-induced smooth muscle strips contractions in a competitive manner in the human detrusor, prostate and prostatic urethra.

HY-P3849

[Lys5,MeLeu9,Nle10]Neurokinin A(4-10) LMN-NKA	Neurokinin Receptor	Neurological Disease
[Lys5,MeLeu9,Nle10]Neurokinin A(4-10) (LMN-NKA), an analogue of Neurokinin A, is a selective and potent *NK2R* agonist. [Lys5,MeLeu9,Nle10]Neurokinin A(4-10) has prokinetic activity. [Lys5,MeLeu9,Nle10]Neurokinin A(4-10) can be used to study the roles of the NK-2 receptor in smooth muscle contraction in numerous tissues.

HY-P1279

[Lys5,MeLeu9,Nle10]-NKA(4-10)
Neurokinin Receptor Inflammation/Immunology

[Lys5,MeLeu9,Nle10]-NKA(4-10) is a highly selective and potent NK₂ receptor agonist, with an IC₅₀ of 6.1 nM.
HY-P3881

(D-Arg1,D-Pro2,D-Phe7,D-His9)-Substance P
Neurokinin Receptor Neurological Disease

(D-Arg1,D-Pro2,D-Phe7,D-His9)-Substance P is a selective NK₁ receptor antagonist.

HY-P1279A

[Lys5,MeLeu9,Nle10]-NKA(4-10) TFA	Neurokinin Receptor	Neurological Disease
[Lys5,MeLeu9,Nle10]-NKA(4-10) TFA is a highly selective and potent *NK₂* receptor agonist, with an IC₅₀ of 6.1 nM.

HY-P3069

γ-Neuropeptide (rabbit)	Neurokinin Receptor	Endocrinology Neurological Disease
γ-Neuropeptide (rabbit) can be isolated from rabbit intestine. γ-Neuropeptide is an endogenous neurokinin peptide that acts as a neurokinin 2 (NK2) receptor agonist. γ-Neuropeptide mediates hypothalamic-pituitary-adrenal (HPA) axis, as well as reproductive hormone release.

HY-P3801

[Glp5,(Me)Phe8,Sar9] Substance P (5-11) DiMe-C7	Neurokinin Receptor	Metabolic Disease Neurological Disease Others
[Glp5,(Me)Phe8,Sar9] Substance P (5-11) (DiMe-C7) is a Substance P (HY-P0201) analogue that has approximately the same effects as Substance P (HY-P0201) on neurokinin 1 receptor (NK1R) in rat brain, but with a much longer duration of action. [Glp5,(Me)Phe8,Sar9] Substance P (5-11) selectively activates dopamine metabolism in the mesencephalon and midbrain cortex of the rat brain. [Glp5,(Me)Phe8,Sar9] Substance P (5-11) also increases motor activity and induces recovery of addictive agent-seeking behavior in rats.

Cat. No.	Product Name	Target	Research Area

HY-P99032

Monalizumab	Checkpoint Kinase (Chk) IFNAR	Cancer Inflammation/Immunology
Monalizumab is a first-in-class immune checkpoint inhibitor targeting Natural Killer Group 2A (NKG2A). Monalizumab, a humanized anti-NKG2A blocking mAb, increases IFN-γ production, thereby promoting NK cell effector functions. Monalizumab can be used for the research of head and neck squamous cell carcinoma (HNSCC).

Cat. No.	Product Name	Target	Category

HY-P0201

Substance P Neurokinin P	Neurokinin Receptor Endogenous Metabolite	Structural Classification Natural Products Endogenous metabolite Source classification Neurological Disease Disease Research Fields Classification of Application Fields Endocrinology
Substance P (Neurokinin P) is a neuropeptide, acting as a neurotransmitter and as a neuromodulator in the CNS. The endogenous receptor for substance P is neurokinin 1 receptor (NK1-receptor, *NK1R*).

HY-P0255

Physalaemin	Neurokinin Receptor	Phenols Ketones, Aldehydes, Acids Classification of Application Fields Disease Research Fields Endocrinology Neurological Disease Source classification Animals
Physalaemin, a non-mammalian tachykinin, binds selectively to neurokinin-1 (NK1) *receptor* with high affinity.

HY-118463

Benzomalvin A	Neurokinin Receptor	Alkaloids Quinoline Alkaloids Source classification Microorganisms
Benzomalvin A is a potent antagonist of neurokinin receptor isolated from Penicillium sp. Benzomalvin A shows inhibitory activity against substance P with K_i values of 12, 42 and 43 μM at the guinea pig, rat and human neurokinin NK1 receptors, respectively.

HY-119552

Acetylaszonalenin LL-S490β	Endogenous Metabolite Neurokinin Receptor	Alkaloids Indole Alkaloids Source classification Microorganisms
Acetylaszonalenin, a prenylated indole derivative, is a fungal metabolite.Acetylaszonalenin is a potent neurokinin-1 (NK1) receptor antagonist. Acetylaszonalenin shows inhibition of [³H]-SP binding to human astrocytoma cells with a K_i of 170 μM.

Species:	Human (30) Rhesus Macaque (1) Mouse (4) Rat (2) Cynomolgus (1)
Tag:	His (25) Tag Free (2) Avi (10) Fc (13)
Source:	HEK293 (31) CHO (1) CHO (1) Sf9 insect cells (2) P. pastoris (2) E. coli (1)

Cat. No.	Product Name	Species	Source

HY-P78166

KIR2DL3 Protein, Human (Biotinylated, HEK293, His-Avi) cl-6; KIR2DL3; KIRCL23; KIR-K7b; KIR-K7c; MGC129943; NKAT; NKAT2; NKAT-2; NKAT2A; NK-receptor; p58; NKAT2GL183; CD158b; CD158B2; GL183; KIR-023GB; KIR2DS5; NKAT2B	Human	HEK293

HY-P78474

KIR2DL3 Protein, Human (HEK293, His-Avi) cl-6; KIR2DL3; KIRCL23; KIR-K7b; KIR-K7c; MGC129943; NKAT; NKAT2; NKAT-2; NKAT2A; NK-receptor; p58; NKAT2GL183; CD158b; CD158B2; GL183; KIR-023GB; KIR2DS5; NKAT2B	Human	HEK293

HY-P76645

SLAMF6 Protein, Human (HEK293)
SLAM Family Member 6; Activating NK receptor; NK-T-B-Antigen; NTB-A; CD352; KALIf
Human HEK293
HY-P76646

SLAMF6 Protein, Human (HEK293, Fc)
SLAM Family Member 6; Activating NK receptor; NK-T-B-Antigen; NTB-A; CD352; KALIf
Human HEK293
HY-P76076

SLAMF6 Protein, Mouse (HEK293, His)
SLAM Family Member 6; Activating NK receptor; NK-T-B-Antigen; NTB-A; CD352; SLAMF6; KALI
Mouse HEK293
HY-P72415

SLAMF6 Protein, Human (HEK293, His-Avi)
SLAM Family Member 6; Activating NK receptor; NK-T-B-Antigen; NTB-A; CD352; SLAMF6; KALI
Human HEK293
HY-P76647

SLAMF6 Protein, Human (226a.a, HEK293, His)
SLAM Family Member 6; Activating NK receptor; NK-T-B-Antigen; NTB-A; CD352; KALIf
Human HEK293
HY-P78421

CD94 Protein, Human (HEK293, His-Avi)
CD94; KLRD1; KP43; NK cell receptor
Human HEK293
HY-P77106

NKp30/NCR3 Protein, Rat (HEK293, His)
Natural cytotoxicity triggering receptor 3; NK-p30; CD337; NCR3
Rat HEK293
HY-P71317

SLAMF6 Protein, Human (198a.a, HEK293, His)
SLAM Family Member 6; Activating NK receptor; NK-T-B-Antigen; NTB-A; CD352; SLAMF6; KALI
Human HEK293

HY-P72018

NKG2D/CD314 Protein, Human (HEK293, Fc) CD314; CD314 antigen ; D12S2489E; Killer cell lectin like receptor subfamily K member 1; Killer cell lectin-like receptor subfamily K member 1; KLR; KLRC4 KLRK1 readthrough; KLRK1; NK cell receptor D; NK lectin-like receptor; NKG2 D activating NK receptor; NKG2 D type II integral membrane protein; NKG2-D; NKG2-D type II integral membrane protein; NKG2-D-activating NK receptor; NKg2d; NKG2D_HUMAN; NKLLR; NKR P2; NKrp2	Human	HEK293

HY-P74687

NKp30/NCR3 Protein, Human (HEK293, His-hFc)
Natural cytotoxicity triggering receptor 3; NK-p30; CD337; NCR3
Human HEK293
HY-P78097

CD94 Protein, Human (Biotinylated, HEK293, His-Avi)
CD94; KLRD1; KP43; NK cell receptor
Human HEK293

HY-P70174

NKp46/NCR1 Protein, Human (HEK293, Fc) rHuNatural Cytotoxicity Triggering receptor 1/NCR1, Fc; Natural cytotoxicity triggering receptor 1; Lymphocyte antigen 94 homolog; NK cell-activating receptor; Natural killer cell p46-related protein; NK-p46; NKp46; hNKp46; CD335; NCR1; LY94;	Human	HEK293

HY-P74688

NKp30/NCR3 Protein, Human (135a.a, HEK293, hFc)
Natural cytotoxicity triggering receptor 3; NK-p30; CD337; NCR3
Human HEK293
HY-P74689

NKp30/NCR3 Protein, Human (135a.a, HEK293, His)
Natural cytotoxicity triggering receptor 3; NK-p30; CD337; NCR3
Human HEK293

HY-P70551

NKG2A Protein, Human (HEK293, His) NKG2-A/NKG2-B type II integral membrane protein; CD159 antigen-like family member A; NK cell receptor A; NKG2-A/B-activating NK receptor; CD159a; KLRC1; NKG2A	Human	HEK293

HY-P77970

KIR2DL2/CD158b1 Protein, Human (HEK293, His-Avi) Killer cell immunoglobulin-like receptor 2DL2; CD158 antigen-like family member B1; MHC class I NK cell receptor; NKAT-6; p58 NK receptor CL-43; CD158b1; KIR2DL2; CD158B1; NKAT6	Human	HEK293

HY-P77971

KIR2DL2/CD158b1 Protein, Human (Biotinylated, HEK293, His-Avi) Killer cell immunoglobulin-like receptor 2DL2; CD158 antigen-like family member B1; MHC class I NK cell receptor; NKAT-6; p58 NK receptor CL-43; CD158b1; KIR2DL2; CD158B1; NKAT6	Human	HEK293

HY-P70688

NKG2D/CD314 Protein, Human (HEK293, His) CD314; KLRK1; CD314 antigen; Killer cell lectin-like receptor subfamily K member 1; killer cell lectin-like receptor subfamily K; member 1; KLR; NK cell receptor D; NKG2-D; NKG2-D type II integral membrane protein; NKG2-D-activating NK receptor; NKG2D	Human	HEK293

HY-P77809

NKG2C/CD159c Protein, Cynomolgus (HEK293, His)
CD159c; KLRC2; NKG2C; NK cell receptor C
Cynomolgus HEK293
HY-P700800

NKG2C/CD159c Protein, Human (HEK293, hFc)
CD159c; KLRC2; NKG2C; NK cell receptor C
Human HEK293
HY-P700801

NKG2C/CD159c Protein, Mouse (HEK293, hFc)
CD159c; KLRC2; NKG2C; NK cell receptor C
Mouse HEK293
HY-P78006

NKG2C/CD159c Protein, Human (HEK293, His-Avi)
CD159c; KLRC2; NKG2C; NK cell receptor C
Human HEK293
HY-P75940

NKG2D/CD314 Protein, Rhesus Macaque (sf9, His)
NKG2-D type II integral membrane protein; NK cell receptor D; KLRK1
Rhesus Macaque Sf9 insect cells
HY-P700799

NKG2C/CD159c Protein, Human (Biotinylated, HEK293, His-Avi)
CD159c; KLRC2; NKG2C; NK cell receptor C
Human HEK293

HY-P71815

KIR2DS3 Protein, Human (P.pastoris, His) KIR2DS3; NKAT7Killer cell immunoglobulin-like receptor 2DS3; MHC class I NK cell receptor; Natural killer-associated transcript 7; NKAT-7	Human	P. pastoris

HY-P71823

KIR2DS1 Protein, Human (P.pastoris, His)
KIR2DS1; CD158 antigen-like family member H; MHC class I NK cell receptor Eb6 ActI
Human P. pastoris
HY-P70562

NKp46/NCR1 Protein, Mouse (HEK293, Fc)
Activating receptor1; mAR-1; Lymphocyte antigen94; Naturalkiller cell p46-related protein; NK-p46; NKp46; mNKp46
Mouse HEK293
HY-P76512

NKG2D/CD314 Protein, Human (CHO, Fc)
NKG2-D type II integral membrane protein; NK cell receptor D; CD314; KLRK1; D12S2489E
Human CHO
HY-P76514

NKp46/NCR1 Protein, Rat (HEK293, Fc)
Activating receptor1; mAR-1; Lymphocyte antigen94; Naturalkiller cell p46-related protein; NK-p46; NKp46; mNKp46
Rat HEK293
HY-P76513

NKG2D/CD314 Protein, Mouse (sf9, Fc)
NKG2-D type II integral membrane protein; NK cell receptor D; CD314; KLRK1; D12S2489E
Mouse Sf9 insect cells

HY-P70354

KIR2DL3 Protein, Human (224a.a, HEK293, His) rHuKiller cell immunoglobulin-like receptor 2DL3/KIR2DL3, His; Killer Cell Immunoglobulin-Like receptor 2DL3; CD158 Antigen-Like Family Member B2; KIR-023GB; Killer Inhibitory receptor cl 2-3; MHC Class I NK Cell receptor; NKAT2a; NKAT2b; Natural Killer-Associated Transcript 2; NKAT-2; p58 Natural Killer Cell receptor Clone C	Human	HEK293

HY-P70754

CD300a/LMIR1 Protein, Human (HEK293, Fc-His) CMRF35-like molecule 8; CD300 antigen-like family member A; CMRF-35-H9; CMRF35-H; IRC1/IRC2; Immunoglobulin superfamily member 12; Inhibitory receptor protein 60; NK inhibitory receptor	Human	HEK293

HY-P700270

CD158d/KIR2DL4 Protein, Human (CHO) rHuCD158d, His; Killer Cell Immunoglobulin-Like receptor 2DL4; CD158 Antigen-Like Family Member D; KIR-103AS; MHC Class I NK Cell receptor KIR103AS; CD158d; KIR2DL4; KIR103AS	Human	CHO
CD158d/KIR2DL4 Protein, Human (CHO) is a recombinant human CD158d expressed in HEK 293 cells with a His tag at the N-terminus. CD158d/KIR2DL4 Protein is an NK cell-activating receptor with inhibitory potential.

HY-P7794

CD158d/KIR2DL4 Protein, Human (HEK293, His) rHuCD158d, His; Killer Cell Immunoglobulin-Like receptor 2DL4; CD158 Antigen-Like Family Member D; KIR-103AS; MHC Class I NK Cell receptor KIR103AS; CD158d; KIR2DL4; KIR103AS	Human	HEK293
CD158d/KIR2DL4 Protein, Human (HEK293, His) is a recombinant human CD158d expressed in HEK 293 cells with a His tag at the N-terminus. CD158d/KIR2DL4 Protein is an NK cell-activating receptor with inhibitory potential.

HY-P77901

OCIL/CLEC2D Protein, Human (HEK293, Fc-Avi)
C-type lectin domain family 2 member D; Lectin-like NK cell receptor; Lectin-like transcript 1; LLT-1; CLAX; LLT1; OCIL; CLEC2D
Human HEK293

HY-P71595

CD300LF Protein, Human (His) CD300 antigen like family member; CD300 antigen-like family member F; CD300 molecule like family member f; CD300f; CD300LF; CLM; CLM-1; CLM1; CMRF35-like molecule 1; IGSF; IgSF13; Inhibitory receptor IREM1; IREM; IREM-1; IREM1; Nepmucin; NK inhibitory receptor; NKIR; TREM	Human	E. coli

Cat. No.	Product Name

HY-B0144S

Pitavastatin-d4 hemicalcium

Pitavastatin-d₄ (hemicalcium) is deuterium labeled Pitavastatin (Calcium). Pitavastatin Calcium (NK-104 hemicalcium) is a potent hydroxymethylglutaryl-CoA (HMG-CoA) reductase inhibitor. Pitavastatin Calcium (NK-104 hemicalcium) inhibits cholesterol synthesis from acetic acid with an IC50 of 5.8 nM in HepG2 cells. Pitavastatin Calcium is an efficient hepatocyte low-density lipoprotein-cholesterol (LDL-C) receptor inducer. Anti-cancer activity[1][2][3].

HY-B0144AS1

Pitavastatin-d5 sodium
Pitavastatin-d₅ (sodium) is the deuterium labeled Pitavastatin sodium. Pitavastatin (NK-104) is a potent hydroxymethylglutaryl-CoA (HMG-CoA) reductase inhibitor. Pitavastatin inhibits cholesterol synthesis from acetic acid with an IC50 of 5.8 nM in HepG2 cells. Pitavastatin is an efficient hepatocyte low-density lipoprotein-cholesterol (LDL-C) receptor inducer. Anti-cancer activity.

HY-16346S

Netupitant-d6

Netupitant-d₆ is the deuterium labeled Netupitant (CID-6451149), which is a highly potent and selective, orally active neurokinin-1 (NK1) receptor antagonist[1].

HY-10053S1

Maropitant-13C,d3
Maropitant-¹³C,d₃ is the ¹³C- and deuterium labeled Maropitant. Maropitant is a selective and orally active neurokinin (NK1) receptor antagonist. Maropitant acts by blocking the binding of substance P within the emetic center and the chemoreceptor trigger zone (CRTZ). Maropitant is highly effective in preventing vomiting[1][2].

NK receptor

Inhibitors & Agonists

Peptides

Inhibitory Antibodies

NaturalProducts

Recombinant Proteins

Isotope-Labeled Compounds

Natural
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