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Results for "

NK-3

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Neurokinin Receptor (28) Neurotensin Receptor (1)
By Research Areas:	Cancer (2) Endocrinology (12) Infection (1) Inflammation/Immunology (1) Neurological Disease (24)

Inhibitors & Agonists

Peptides

Antibodies

Targets Recommended: Neurokinin Receptor

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-107692

SB 218795	Neurokinin Receptor	Neurological Disease
SB 218795 is a potent and selective non-peptide NK3 receptor antagonist, with a K_i 13 nM for *hNK3. SB 218795 shows about 90-fold and 7000-fold selectivity for hNK3 over hNK2 and hNK1, respectively. SB 218795 can inhibit NK3* receptor-mediated pupillary constriction of the rabbit .

HY-P0187

Senktide

1 Publications Verification

Neurokinin Receptor Neurological Disease Endocrinology

Senktide is a tachykinin NK₃ receptor agonist.

Senktide 1 Publications Verification	Neurokinin Receptor	Neurological Disease Endocrinology
Senktide is a tachykinin NK₃ receptor agonist.

HY-149358

NK3R-IN-1	Neurokinin Receptor	Endocrinology
NK3R-IN-1 (compound 16x), a imidazolepiperazine derivative, is an orally active Neurokinin Receptor *NK3R* inhibitor. NK3R-IN-1 decreases blood luteinizing hormone levels in ovariectomy (OVX) model .

HY-P3802

[D-Trp2,7,9] Substance P	Neurokinin Receptor	Neurological Disease
[D-Trp2,7,9] Substance P is a tachykinin (Neurokinin Receptor) antagonist with K_i values of 1 μM, 1.3 μM, and ~9 μM for NK-1, NK-2,and *NK-3* receptor, respectively .

HY-116822

SSR 146977	Neurokinin Receptor	Neurological Disease
SSR 146977 is a potent and selective antagonist of the tachykinin NK3 receptor. SSR 146977 inhibits the binding of radioactive neurokinin B to NK3 receptors in Chinese hamster ovary cells, with a K_i of 0.26 nM .

HY-P0006

Eledoisin

Eledone peptide
Neurokinin Receptor Others

Eledoisin (Eledone peptide) is a specific agonist of NK2 and NK3 receptors.

Eledoisin Eledone peptide	Neurokinin Receptor	Others
Eledoisin (Eledone peptide) is a specific agonist of NK2 and *NK3* receptors.

HY-15722

SB-222200 2 Publications Verification	Neurokinin Receptor	Neurological Disease Endocrinology
SB-222200 is a potent, selective, orally active and blood-brain barrier (BBB) penetrant NK-3 receptor antagonist. SB-222200 is developed for central nervous system (CNS) disorders .

HY-133206A

Fosnetupitant chloride monohydrochloride Pronetupitant chloride monohydrochloride	Neurokinin Receptor	Cancer
Fosnetupitant chloride monohydrochloride (Pronetupitant chloride monohydrochloride) is an NK1 antagonist with pK_i values of 9.5, 6.1 for human NK1 and NK3 receptor, respectively. Fosnetupitant chloride monohydrochloride is a methylene phosphate prodrug of Netupitant .

HY-P3862

[MePhe7]-Neurokinin B	Neurokinin Receptor	Neurological Disease Endocrinology
[MePhe7]-Neurokinin B is an *neurokinin NK-3* receptor** (NK3R) agonist with an IC₅₀ value of 3 nM. [MePhe7]-Neurokinin B is a potential regulator of pulsatile gonadotropin-releasing hormone (GnRH) secretion via activation of the neurokinin-3 receptor (NK3R) .

HY-14551

Osanetant SR142801	Neurokinin Receptor	Neurological Disease
Osanetant (SR142801) is a selective NK3 receptor antagonist. Osanetant produces anxiolytic- and antidepressant-like effects and is researched for schizophrenia .

HY-107693

SSR 146977 hydrochloride	Neurokinin Receptor	Neurological Disease Inflammation/Immunology
SSR 146977 hydrochloride is a potent and selective antagonist of the tachykinin *NK₃* receptor. SSR 146977 hydrochloride can be used in the study of psychiatric disorders and airway inflammation .

HY-P3854

GR 83074	Neurokinin Receptor	Neurological Disease
GR 83074 is a potent and selective NK-2 (Neurokinin Receptor) antagonist with a pK_B of 8.23. GR 83074 is inactive as an NK-3 antagonist and exhibits a 340-fold NK-2/NK-1 selectivity .

HY-P4709

(Trp7,β-Ala8)-Neurokinin A (4-10)

Neurokinin Receptor Neurological Disease

(Trp7,β-Ala8)-Neurokinin A (4-10) is a potent neurokinin-3 (NK3) antagonist .

(Trp7,β-Ala8)-Neurokinin A (4-10)	Neurokinin Receptor	Neurological Disease
(Trp7,β-Ala8)-Neurokinin A (4-10) is a potent **neurokinin-3 (NK3)** antagonist .

HY-14551B

(S)-Osanetant (S)-SR142801	Neurotensin Receptor	Neurological Disease
(S)-Osanetant is the S-enantiomer of Osanetant. Osanetant (SR142801) is a selective NK3 receptor antagonist. Osanetant produces anxiolytic- and antidepressant-like effects and is researched for schizophrenia .

HY-151413

MEN 10207	Neurokinin Receptor	Neurological Disease
MEN 10207 is a selective NK-2 tachykinin receptor (Neurokinin Receptor) antagonist. MEN 10207 has pA2 values of 5.2, 7.9 and 4.9 in three monoreceptor in vitro assays for NK-1, NK-2 and NK-3 tachykinin receptors, respectively.

HY-P1277

GR 94800	Neurokinin Receptor	Neurological Disease
GR 94800 is a potent and selective NK₂ receptor peptide antagonist, with pK_B values of 9.6, 6.4 and 6.0 for NK₂, NK₁ and NK₃ receptors, respectively .

HY-P1277A

GR 94800 TFA	Neurokinin Receptor	Neurological Disease
GR 94800 TFA is a potent and selective NK₂ receptor peptide antagonist, with pK_B values of 9.6, 6.4 and 6.0 for NK₂, NK₁ and NK₃ receptors, respectively .

HY-P1198

Hemokinin 1, human	Neurokinin Receptor	Neurological Disease
Hemokinin 1, human is a selective tachykinin neurokinin 1 (NK1) receptor full agonist. Hemokinin 1, human is a full agonist at NK2 and *NK3* receptor. Hemokinin 1, human can produces an opioid-independent analgesia .

HY-P1278

GR 64349	Neurokinin Receptor	Neurological Disease
GR 64349 is a potent and highly selective NK₂ receptor peptide antagonist, with an EC₅₀ of 3.7 nM in rat colon. GR 64349 exhibits selectivity >1000 and >300-fold with respect to NK₁ and NK₃ receptors, respectively .

HY-P1278A

GR 64349 TFA	Neurokinin Receptor	Neurological Disease
GR 64349 is a potent and highly selective NK₂ receptor peptide antagonist, with an EC₅₀ of 3.7 nM in rat colon. GR 64349 exhibits selectivity >1000 and >300-fold with respect to NK₁ and NK₃ receptors, respectively .

HY-P1198A

Hemokinin 1, human TFA	Neurokinin Receptor	Neurological Disease
Hemokinin 1, human TFA is a selective tachykinin neurokinin 1 (NK1) receptor full agonist. Hemokinin 1, human TFA is a full agonist at NK2 and *NK3* receptor. Hemokinin 1, human TFA can produces an opioid-independent analgesia .

HY-101249

L-732138
L-732138 is a selective, potent and competitive neurokinin-1 (NK-1) receptor antagonist with an IC₅₀ of 2.3 nM. L-732138 has 200-fold more potent in cloned human NK-1 receptors than cloned rat NK-1 receptors, and has > 1000-fold more potent than human NK-2 and NK-3 receptors. L-732138 can reduce hyperalgesia and has antitumor action .

HY-14552

Talnetant 3 Publications Verification SB 223412	Neurokinin Receptor	Neurological Disease Endocrinology
Talnetant (SB 223412) is a selective, competitive, brain-permeable *NK3* receptor antagonist with a K_i of 1.4 nM in hNK-3-CHO cells. Talnetant is 100-fold more selective for hNK-3 relative to the hNK-2 receptor and has no affinity for hNK-1. Talnetant can be used in schizophrenia-related studies ^[3].

HY-14552A

Talnetant hydrochloride SB 223412 hydrochloride; SB 223412-A	Neurokinin Receptor	Neurological Disease Endocrinology
Talnetant (SB 223412) hydrochloride is a selective, competitive, brain-permeable *NK3* receptor antagonist with a K_i of 1.4 nM in hNK-3-CHO cells. Talnetant hydrochloride is 100-fold more selective for hNK-3 relative to the hNK-2 receptor and has no affinity for hNK-1. Talnetant hydrochloride can be used in schizophrenia-related studies ^[3].

HY-19633

CS-003 Free base	Neurokinin Receptor	Infection Endocrinology
CS-003 Free base (CS-003), a triple tachykinin receptor antagonist, shows high affinities for human (Neurokinin) NK1, NK2 and NK3 receptors with K_i values of 2.3 nM, 0.54 nM and 0.74 nM, respectively. CS-003 Free base (CS-003) has therapeutic efficacy on respiratory diseases associated with neurokinins.

HY-107691

GR 159897	Neurokinin Receptor	Neurological Disease Endocrinology Cancer
GR 159897 is a highly potent, selective, competitive, brain-penetrated non-peptide neurokinin 2 (NK₂) receptor antagonist. GR 159897 has little or no affinity for NK₁ and NK₃ receptors. GR 159897 inhibits binding of [ ³H]GR100679 to human NK₂ (hNK₂)-CHO cells and rat colon membranes with pK_is of 9.51 and 10, respectively. Antagonizes bronchoconstriction. Anxiolytic-like and anti-tumor effects .

HY-P0242

Neurokinin B	Neurokinin Receptor	Neurological Disease Endocrinology
Neurokinin B belongs to the tachykinin family of peptides. Neurokinin B binds a family of GPCRs-including neurokinin receptor 1 (NK1R), NK2R, and NK3R-to mediate their biological effect .

HY-P0242A

Neurokinin B TFA	Neurokinin Receptor	Neurological Disease Endocrinology
Neurokinin B TFA belongs to the tachykinin family of peptides. Neurokinin B binds a family of GPCRs-including neurokinin receptor 1 (NK1R), NK2R, and NK3R-to mediate their biological effect .

HY-14432

Pavinetant 1 Publications Verification MLE-4901; AZD2624; AZD4901	Neurokinin Receptor	Neurological Disease Endocrinology
Pavinetant (MLE-4901) is a neurokinin-3 receptor (NK3R) antagonist.

HY-19632

Fezolinetant 2 Publications Verification ESN-364	Neurokinin Receptor	Endocrinology
Fezolinetant is an antagonist of the neurokinin 3 receptor (NK3R), used for the treatment of menopausal hot flushes.

Senktide 1 Publications Verification	Neurokinin Receptor	Neurological Disease Endocrinology
Senktide is a tachykinin NK₃ receptor agonist.

Eledoisin Eledone peptide	Neurokinin Receptor	Others
Eledoisin (Eledone peptide) is a specific agonist of NK2 and *NK3* receptors.

[D-Trp2,7,9] Substance P	Neurokinin Receptor	Neurological Disease
[D-Trp2,7,9] Substance P is a tachykinin (Neurokinin Receptor) antagonist with K_i values of 1 μM, 1.3 μM, and ~9 μM for NK-1, NK-2,and *NK-3* receptor, respectively .

[MePhe7]-Neurokinin B	Neurokinin Receptor	Neurological Disease Endocrinology
[MePhe7]-Neurokinin B is an *neurokinin NK-3* receptor** (NK3R) agonist with an IC₅₀ value of 3 nM. [MePhe7]-Neurokinin B is a potential regulator of pulsatile gonadotropin-releasing hormone (GnRH) secretion via activation of the neurokinin-3 receptor (NK3R) .

GR 83074	Neurokinin Receptor	Neurological Disease
GR 83074 is a potent and selective NK-2 (Neurokinin Receptor) antagonist with a pK_B of 8.23. GR 83074 is inactive as an NK-3 antagonist and exhibits a 340-fold NK-2/NK-1 selectivity .

(Trp7,β-Ala8)-Neurokinin A (4-10)	Neurokinin Receptor	Neurological Disease
(Trp7,β-Ala8)-Neurokinin A (4-10) is a potent **neurokinin-3 (NK3)** antagonist .

MEN 10207	Neurokinin Receptor	Neurological Disease
MEN 10207 is a selective NK-2 tachykinin receptor (Neurokinin Receptor) antagonist. MEN 10207 has pA2 values of 5.2, 7.9 and 4.9 in three monoreceptor in vitro assays for NK-1, NK-2 and NK-3 tachykinin receptors, respectively.

GR 94800	Neurokinin Receptor	Neurological Disease
GR 94800 is a potent and selective NK₂ receptor peptide antagonist, with pK_B values of 9.6, 6.4 and 6.0 for NK₂, NK₁ and NK₃ receptors, respectively .

GR 94800 TFA	Neurokinin Receptor	Neurological Disease
GR 94800 TFA is a potent and selective NK₂ receptor peptide antagonist, with pK_B values of 9.6, 6.4 and 6.0 for NK₂, NK₁ and NK₃ receptors, respectively .

Hemokinin 1, human	Neurokinin Receptor	Neurological Disease
Hemokinin 1, human is a selective tachykinin neurokinin 1 (NK1) receptor full agonist. Hemokinin 1, human is a full agonist at NK2 and *NK3* receptor. Hemokinin 1, human can produces an opioid-independent analgesia .

GR 64349	Neurokinin Receptor	Neurological Disease
GR 64349 is a potent and highly selective NK₂ receptor peptide antagonist, with an EC₅₀ of 3.7 nM in rat colon. GR 64349 exhibits selectivity >1000 and >300-fold with respect to NK₁ and NK₃ receptors, respectively .

GR 64349 TFA	Neurokinin Receptor	Neurological Disease
GR 64349 is a potent and highly selective NK₂ receptor peptide antagonist, with an EC₅₀ of 3.7 nM in rat colon. GR 64349 exhibits selectivity >1000 and >300-fold with respect to NK₁ and NK₃ receptors, respectively .

Hemokinin 1, human TFA	Neurokinin Receptor	Neurological Disease
Hemokinin 1, human TFA is a selective tachykinin neurokinin 1 (NK1) receptor full agonist. Hemokinin 1, human TFA is a full agonist at NK2 and *NK3* receptor. Hemokinin 1, human TFA can produces an opioid-independent analgesia .

Neurokinin B	Neurokinin Receptor	Neurological Disease Endocrinology
Neurokinin B belongs to the tachykinin family of peptides. Neurokinin B binds a family of GPCRs-including neurokinin receptor 1 (NK1R), NK2R, and NK3R-to mediate their biological effect .

Neurokinin B TFA	Neurokinin Receptor	Neurological Disease Endocrinology
Neurokinin B TFA belongs to the tachykinin family of peptides. Neurokinin B binds a family of GPCRs-including neurokinin receptor 1 (NK1R), NK2R, and NK3R-to mediate their biological effect .

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