Search Result

Results for "

NK1

" in MCE Product Catalog:

By Targets:	Cytochrome P450 (1) Drug Metabolite (2) Endogenous Metabolite (3) Isotope-Labeled Compounds (1) JNK (1) Neurokinin Receptor (70)
By Research Areas:	Cancer (13) Cardiovascular Disease (1) Endocrinology (27) Infection (1) Inflammation/Immunology (7) Metabolic Disease (1) Neurological Disease (60)

Inhibitors & Agonists

Peptides

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas

HY-145250

NK1 receptor antagonist 2	Neurokinin Receptor	Neurological Disease
NK1 receptor antagonist 2 is a NK1 receptor antagonist. NK1 receptor antagonist 2 can be used for the research of tinnitus and hearing loss.

HY-106659

SCH 900978 NK-1 Antagonist 1	Neurokinin Receptor	Neurological Disease Endocrinology
SCH 900978 (NK-1 Antagonist 1) is an antagonist of NK-1 receptor, used in the research of NK-1 related diseases and conditions such as cough, overactive bladder, alcohol dependency and depression.

HY-109147A

Imnopitant dihydrochloride
Neurokinin Receptor Neurological Disease

Imnopitant dihydrochloride is a neurokinin NK1 receptor antagonist.
HY-P2000

Septide
(Pyr6,Pro9)-Substance P
Neurokinin Receptor Neurological Disease

Septide ((Pyr6,Pro9)-Substance P) is a potent NK1 receptor agonist with a K_d value of 0.55 nM.

Imnopitant dihydrochloride	Neurokinin Receptor	Neurological Disease
Imnopitant dihydrochloride is a neurokinin NK1 receptor antagonist.

Septide (Pyr6,Pro9)-Substance P	Neurokinin Receptor	Neurological Disease
Septide ((Pyr6,Pro9)-Substance P) is a potent NK1 receptor agonist with a K_d value of 0.55 nM.

HY-P3891

Substance P (4-11)	Neurokinin Receptor	Neurological Disease
Substance P (4-11), the C-terminus fragment of Substance P (Substance P (HY-P0201)), is a Substance P agonist that shows highly selective for **NK1 receptors**.

HY-12142

Vofopitant GR 205171	Neurokinin Receptor	Neurological Disease Endocrinology
Vofopitant is potent *tachykinin NK₁* receptor antagonist, with pK_i*s of 10.6, 9.5, and 9.8 for human, rat and ferret NK₁* receptor, respectively.

HY-12114

Serlopitant
VPD-737; MK-0594
Neurokinin Receptor Neurological Disease Endocrinology

Serlopitant is a selective Neurokinin-1 (NK-1) receptor antagonist.
HY-16732

Tradipitant
VLY-686; LY686017
Neurokinin Receptor Neurological Disease Endocrinology

Tradipitant (VLY-686) is a neurokinin-1 (NK-1) antagonist.

Serlopitant VPD-737; MK-0594	Neurokinin Receptor	Neurological Disease Endocrinology
Serlopitant is a selective **Neurokinin-1 (NK-1)** receptor antagonist.

Tradipitant VLY-686; LY686017	Neurokinin Receptor	Neurological Disease Endocrinology
Tradipitant (VLY-686) is a *neurokinin-1* (NK-1) antagonist.

HY-101249

L-732138	Neurokinin Receptor	Cancer Neurological Disease
L-732138 is a selective, potent and competitive neurokinin-1 (NK-1) receptor antagonist with an IC₅₀ of 2.3 nM. L-732138 has 200-fold more potent in cloned human NK-1 receptors than cloned rat NK-1 receptors, and has > 1000-fold more potent than human NK-2 and NK-3 receptors. L-732138 can reduce hyperalgesia and has antitumor action.

HY-P1192

GR-73632	Neurokinin Receptor	Neurological Disease Endocrinology
GR-73632 is a novel tachykinin neurokinin 1 (NK-1) receptor agonist. GR-73632 acts directly on the peripheral terminals of primary sensory neurons through NK1 receptor which convey itch signals.

HY-108480

SDZ NKT 343	Neurokinin Receptor	Neurological Disease
SDZ NKT 343 is a selective, orally active NK₁ receptor antagonist with an IC₅₀ of 0.62 nM against human NK₁ receptor. SDZ NKT 343 has good analgesic activity.

HY-108481

L-760735	Neurokinin Receptor	Neurological Disease
L-760735 is a high affinity, selective and orally active NK1 receptor antagonist with an IC₅₀ of 0.19 nM for human NK1 receptors. L-760735 exhibits anxiolytic and antidepressant-like effects.

HY-P1738

[Sar9] Substance P
Neurokinin Receptor Neurological Disease Endocrinology

[Sar9] Substance P is a potent and selective neurokinin (NK)-1 receptor agonist.
HY-109147

Imnopitant
Neurokinin Receptor Endocrinology Neurological Disease

Imnopitant is a NK1 receptor antagonist (WO2020132716, compound 1) ^[1].
HY-P0061

Vapreotide
RC160; BMY 41606
Neurokinin Receptor Cancer

Vapreotide is a neurokinin-1 (NK1) receptor antagonist, with an IC₅₀ of 330 nM.

[Sar9] Substance P	Neurokinin Receptor	Neurological Disease Endocrinology
[Sar9] Substance P is a potent and selective *neurokinin (NK)-1* receptor** agonist.

Imnopitant	Neurokinin Receptor	Endocrinology Neurological Disease
Imnopitant is a NK1 receptor antagonist (WO2020132716, compound 1) ^[1].

Vapreotide RC160; BMY 41606	Neurokinin Receptor	Cancer
Vapreotide is a neurokinin-1 (NK1) receptor antagonist, with an IC₅₀ of 330 nM.

HY-12143

Vofopitant dihydrochloride GR 205171A	Neurokinin Receptor	Cancer Neurological Disease Endocrinology
Vofopitant dihydrochloride (GR 205171A) is a potent, selective and orally available tachykinin neurokinin 1(NK1) receptor antagonist, inhibits [³H]SP binding to the NK1 receptor with pK_i values of 9.5 and 10.6 in rat and human membranes respectively, acts as a potential broad-spectrum anti-emetic agent.

HY-G0012

Netupitant metabolite Monohydroxy Netupitant Monohydroxy Netupitant	Neurokinin Receptor Drug Metabolite	Endocrinology
Monohydroxy Netupitant is the metabolite of Netupitant, which is a highly selective NK1 receptor antagonist.

HY-U00207

MEN11467
Neurokinin Receptor Neurological Disease Endocrinology

MEN11467 is a selective and orally- effective peptidomimetic tachykinin NK₁ receptor antagonist.

MEN11467	Neurokinin Receptor	Neurological Disease Endocrinology
MEN11467 is a selective and orally- effective peptidomimetic *tachykinin NK₁* receptor** antagonist.

HY-105215

FK888	Neurokinin Receptor	Inflammation/Immunology
FK888 is a potent, selective, and high affinity dipeptide *NK1* receptor antagonist. FK888 displaces [3H]-SP binding with a K_i value of 0.69 nM and 0.45 microM. FK888 also inhibits SP-induced airway oedema in guinea-pig after both intravenous and oral administration.

HY-G0011

Netupitant metabolite Netupitant N-oxide Netupitant N-oxide	Drug Metabolite	Neurological Disease Endocrinology
Netupitant N-oxide is the metabolite of Netupitant, which is a highly selective NK1 receptor antagonist.

HY-P0201

Substance P Neurokinin P	Neurokinin Receptor Endogenous Metabolite	Neurological Disease Endocrinology Cancer
Substance P (Neurokinin P) is a neuropeptide, acting as a neurotransmitter and as a neuromodulator in the CNS. The endogenous receptor for substance P is neurokinin 1 receptor (NK1-receptor, *NK1R*).

HY-P2475

[Pro9]-Substance P
Neurokinin Receptor Neurological Disease

[Pro9]-Substance P is a potent, reversible and selective agonist of NK-1 tachykinin receptors with an EC₅₀ of 0.93 nM.
HY-P0255

Physalaemin
Neurokinin Receptor Neurological Disease Endocrinology

Physalaemin, a non-mammalian tachykinin, binds selectively to neurokinin-1 (NK1) receptor with high affinity.

[Pro9]-Substance P	Neurokinin Receptor	Neurological Disease
[Pro9]-Substance P is a potent, reversible and selective agonist of *NK-1* tachykinin receptors with an EC₅₀ of 0.93 nM.

Physalaemin	Neurokinin Receptor	Neurological Disease Endocrinology
Physalaemin, a non-mammalian tachykinin, binds selectively to *neurokinin-1* (NK1) receptor with high affinity.

HY-P0201A

Substance P TFA Neurokinin P TFA	Neurokinin Receptor Endogenous Metabolite	Endocrinology Neurological Disease Cancer
Substance P TFA (Neurokinin P TFA) is a neuropeptide, acting as a neurotransmitter and as a neuromodulator in the CNS. The endogenous receptor for substance P is neurokinin 1 receptor (NK1-receptor, *NK1R*).

HY-P1194A

Spantide I TFA	Neurokinin Receptor	Inflammation/Immunology
Spantide I TFA, a substance P analog, is a selective NK₁ receptor antagonist, with K_i values of 230 nM and 8150 nM for NK₁ and NK₂ receptor, respectively. Spantide I provides an approach to reduce type 1 and enhance the type 2 cytokine IL-10 in the infected cornea, leading to a significant reduction in corneal perforation.

HY-P1194

Spantide I	Neurokinin Receptor	Inflammation/Immunology
Spantide I, a substance P analog, is a selective NK₁ receptor antagonist, with K_i values of 230 nM and 8150 nM for NK₁ and NK₂ receptor, respectively. Spantide I provides an approach to reduce type 1 and enhance the type 2 cytokine IL-10 in the infected cornea, leading to a significant reduction in corneal perforation.

HY-17615

Fosnetupitant Pronetupitant	Neurokinin Receptor	Neurological Disease
Fosnetupitant (Pronetupitant) a methylene phosphate prodrug of Netupitant. Fosnetupitant (Pronetupitant) exhibits a pK_i of 9.5 for human NK₁ receptor.

HY-P0061A

Vapreotide acetate RC-160 acetate; BMY-41606 acetate	Neurokinin Receptor	Cancer
Vapreotide acetate (RC-160 acetate; BMY-41606 acetate) is a neurokinin-1 (NK1) receptor antagonist, with an IC₅₀ of 330 nM.

HY-P3092

Phyllomedusin	Neurokinin Receptor	Neurological Disease
Phyllomedusin, an tachykinin decapeptide, is a NK1 receptor agonist. Phyllomedusin has vasodilating activity and provokes the contraction of the pylorus.

HY-P1012

[Sar9,Met(O2)11]-Substance P
Neurokinin Receptor Neurological Disease Endocrinology

[Sar9,Met(O2)11]-Substance P is a tachykinin NK₁ receptor selective agonist.

[Sar9,Met(O2)11]-Substance P	Neurokinin Receptor	Neurological Disease Endocrinology
[Sar9,Met(O2)11]-Substance P is a *tachykinin NK₁* receptor** selective agonist.

HY-P2546

Biotin-Substance P	Neurokinin Receptor	Neurological Disease
Biotin-Substance P is the biotin tagged Substance P. Substance P (Neurokinin P) is a neuropeptide, acting as a neurotransmitter and as a neuromodulator in the CNS. The endogenous receptor for substance P is neurokinin 1 receptor (NK1-receptor, NK1R).

HY-P1012A

[Sar9,Met(O2)11]-Substance P TFA
Neurokinin Receptor Neurological Disease Endocrinology

[Sar9,Met(O2)11]-Substance P TFA is a tachykinin NK₁ receptor selective agonist.

[Sar9,Met(O2)11]-Substance P TFA	Neurokinin Receptor	Neurological Disease Endocrinology
[Sar9,Met(O2)11]-Substance P TFA is a *tachykinin NK₁* receptor** selective agonist.

HY-P3890

Substance P (5-11)	Neurokinin Receptor	Neurological Disease
Substance P (5-11), the C-terminal heptapeptide of Substance P (Substance P (HY-P0201)), is a neuropeptide. Substance P (5-11) binds to **NK-1 tachykinin receptor**.

HY-18006

NKP608	Neurokinin Receptor	Neurological Disease Endocrinology
NKP608 is a non-peptidic derivative of 4-aminopiperidine which acts as a selective, specific and potent antagonist at the neurokinin-1 (NK-1) receptor both in vitro(IC50=2.6 nM) and in vivo.

HY-14405A

Casopitant mesylate GW679769B	Neurokinin Receptor Cytochrome P450	Neurological Disease Cancer
Casopitant mesylate (GW679769B) is a potent, selective, brain permeable and orally active *neurokinin 1 (NK1) receptor* antagonist. Casopitant mesylate is a second in the class of antiemetics that acts to antagonise the emetogenic effect of substance P. Casopitant mesylate is also a substrate and a weak-to-moderate inhibitor of CYP3A4. Casopitant mesylate can be used for chemotherapy-induced nausea and vomiting (CINV) and postoperative nausea and vomiting (PONV).

HY-P1030

Hemokinin 1 (mouse)	Neurokinin Receptor	Endocrinology
Hemokinin 1 (mouse) is a selective agonist of neurokinin-1 receptor, with K_i of 0.175 nM and 560 nM for human NK1 receptor and human NK2 receptor, respectively.

HY-108479

Nolpitantium SR140333	Neurokinin Receptor	Neurological Disease
Nolpitantium (SR140333) is a potent, selective, competitive, non-peptide tachykinin NK₁ receptor antagonist. Nolpitantium blocks the activation of rat thalamic neurons after nociceptive stimulation.

HY-P3802

[D-Trp2,7,9] Substance P	Neurokinin Receptor	Neurological Disease
[D-Trp2,7,9] Substance P is a tachykinin (Neurokinin Receptor) antagonist with K_i values of 1 μM, 1.3 μM, and ~9 μM for *NK-1, NK-2,and NK-3* receptor, respectively.

HY-16346S

Netupitant-d6 CID-6451149-d₆	Neurokinin Receptor	Endocrinology Neurological Disease
Netupitant-d₆ is the deuterium labeled Netupitant (CID-6451149), which is a highly potent and selective, orally active neurokinin-1 (NK1) receptor antagonist[1].

HY-P3889

Substance P (6-11)	Neurokinin Receptor	Neurological Disease
Substance P (6-11) is the C-terminal hexapeptideamide of Substance P (Substance P (HY-P0201)). Substance P (6-11) binds to NK-1 tachykinin receptor. Substance P (6-11) shows depolarization of motoneurons and a hypotensive effect.

HY-P1277

GR 94800	Neurokinin Receptor	Neurological Disease
GR 94800 is a potent and selective NK₂ receptor peptide antagonist, with pK_B values of 9.6, 6.4 and 6.0 for NK₂, NK₁ and NK₃ receptors, respectively.

HY-P1277A

GR 94800 TFA	Neurokinin Receptor	Neurological Disease
GR 94800 TFA is a potent and selective NK₂ receptor peptide antagonist, with pK_B values of 9.6, 6.4 and 6.0 for NK₂, NK₁ and NK₃ receptors, respectively.

HY-P3881

(D-Arg1,D-Pro2,D-Phe7,D-His9)-Substance P
Neurokinin Receptor Neurological Disease

(D-Arg1,D-Pro2,D-Phe7,D-His9)-Substance P is a selective NK₁ receptor antagonist.

(D-Arg1,D-Pro2,D-Phe7,D-His9)-Substance P	Neurokinin Receptor	Neurological Disease
(D-Arg1,D-Pro2,D-Phe7,D-His9)-Substance P is a selective NK₁ receptor antagonist.

HY-10053

Maropitant	Neurokinin Receptor	Neurological Disease Endocrinology
Maropitant is a selective and orally active *neurokinin (NK1) receptor* antagonist. Maropitant acts by blocking the binding of substance P within the emetic center and the chemoreceptor trigger zone (CRTZ). Maropitant is highly effective in preventing vomiting.

HY-14406A

L-733060 hydrochloride	Neurokinin Receptor	Cancer Neurological Disease
L-733060 hydrochloride is a potent tachykinin NK₁ receptor antagonist. L-733060 hydrochloride inhibits neurogenic plasma extravasation at doses that do not cause adverse cardiovascular effects in rodents and also acts as an antitumoral agent.

HY-16346

Netupitant CID 6451149	Neurokinin Receptor	Neurological Disease Endocrinology
Netupitant (CID-6451149) is a highly potent, selective and orally active **neurokinin-1 (NK₁) receptor antagonist with a K_i** of 0.95 nM for hNK₁ in CHO cells. Netupitant has antiemetic affect.

HY-151413

MEN 10207	Neurokinin Receptor	Neurological Disease
MEN 10207 is a selective NK-2 tachykinin receptor (Neurokinin Receptor) antagonist. MEN 10207 has pA₂ values of 5.2, 7.9 and 4.9 in three monoreceptor in vitro assays for NK-1, NK-2 and NK-3 tachykinin receptors, respectively.

HY-122347A

Orvepitant maleate GW823296 maleate	Neurokinin Receptor	Neurological Disease
Orvepitant maleate (GW823296 maleate) is potent, selective, orally active and well-tolerated **neurokinin-1 receptor (NK-1) antagonist with a pK_i of 10.2 for human neurokinin-1 receptor*. Orvepitant maleate can across the blood-brain barrier. Orvepitant maleate has the potential for depressive disorder and chronic refractory cough (CRC) treatment.*

HY-119552

Acetylaszonalenin LL-S490β	Endogenous Metabolite Neurokinin Receptor	Neurological Disease
Acetylaszonalenin, a prenylated indole derivative, is a fungal metabolite.Acetylaszonalenin is a potent **neurokinin-1 (NK1)** receptor antagonist. Acetylaszonalenin shows inhibition of [³H]-SP binding to human astrocytoma cells with a K_i of 170 μM.

HY-118463

Benzomalvin A	Neurokinin Receptor	Neurological Disease
Benzomalvin A is a potent antagonist of neurokinin receptor isolated from Penicillium sp. Benzomalvin A shows inhibitory activity against substance P with K_i values of 12, 42 and 43 μM at the guinea pig, rat and human neurokinin NK1 receptors, respectively.

HY-P1278A

GR 64349 TFA	Neurokinin Receptor	Neurological Disease
GR 64349 is a potent and highly selective NK₂ receptor peptide antagonist, with an EC₅₀ of 3.7 nM in rat colon. GR 64349 exhibits selectivity >1000 and >300-fold with respect to NK₁ and NK₃ receptors, respectively.

HY-P1278

GR 64349	Neurokinin Receptor	Neurological Disease
GR 64349 is a potent and highly selective NK₂ receptor peptide antagonist, with an EC₅₀ of 3.7 nM in rat colon. GR 64349 exhibits selectivity >1000 and >300-fold with respect to NK₁ and NK₃ receptors, respectively.

HY-P1198

Hemokinin 1, human	Neurokinin Receptor	Neurological Disease
Hemokinin 1, human is a selective tachykinin neurokinin 1 (NK1) receptor full agonist. Hemokinin 1, human is a full agonist at NK2 and NK3 receptor. Hemokinin 1, human can produces an opioid-independent analgesia.

HY-14751A

Rolapitant hydrochloride SCH619734 hydrochloride	Neurokinin Receptor	Neurological Disease
Rolapitant (SCH619734) hydrochloride is a potent, selective, long-acting and orally active *neurokinin 1 (NK1) receptor* antagonist with a K_i of 0.66 nM. Rolapitant hydrochloride does not interact with CYP3A4. Rolapitant hydrochloride shows potent anti-emetic activity in a ferret emesis model.

HY-16436

Rolapitant hydrochloride hydrate SCH619734 hydrochloride hydrate	Neurokinin Receptor	Cancer Neurological Disease
Rolapitant hydrochloride hydrate (SCH619734 hydrochloride hydrate) is a potent, selective, long-acting and orally active *neurokinin 1 (NK1) receptor* antagonist with a K_i of 0.66 nM. Rolapitant hydrochloride hydrate does not interact with CYP3A4. Rolapitant hydrochloride hydrate shows potent anti-emetic activity in a ferret emesis model.

HY-14751

Rolapitant SCH619734	Neurokinin Receptor	Cancer Neurological Disease
Rolapitant (SCH619734) is a potent, selective, long-acting and orally active *neurokinin 1 (NK1) receptor* antagonist with a K_i of 0.66 nM. Rolapitant does not interact with CYP3A4. Rolapitant shows potent anti-emetic activity in a ferret emesis model.

HY-P1198A

Hemokinin 1, human TFA	Neurokinin Receptor	Neurological Disease
Hemokinin 1, human TFA is a selective tachykinin neurokinin 1 (NK1) receptor full agonist. Hemokinin 1, human TFA is a full agonist at NK2 and NK3 receptor. Hemokinin 1, human TFA can produces an opioid-independent analgesia.

HY-10053S1

Maropitant-13C,d3	Isotope-Labeled Compounds Neurokinin Receptor	Neurological Disease Endocrinology
Maropitant-¹³C,d₃ is the ¹³C- and deuterium labeled Maropitant. Maropitant is a selective and orally active neurokinin (NK1) receptor antagonist. Maropitant acts by blocking the binding of substance P within the emetic center and the chemoreceptor trigger zone (CRTZ). Maropitant is highly effective in preventing vomiting[1][2].

HY-19633

CS-003 Free base	Neurokinin Receptor	Infection Endocrinology
CS-003 Free base (CS-003), a triple tachykinin receptor antagonist, shows high affinities for human (Neurokinin) NK1, NK2 and NK3 receptors with K_i values of 2.3 nM, 0.54 nM and 0.74 nM, respectively. CS-003 Free base (CS-003) has therapeutic efficacy on respiratory diseases associated with neurokinins.

HY-P3805

[D-Pro4,D-Trp7,9,Nle11] Substance P (4-11)	Neurokinin Receptor	Neurological Disease Cardiovascular Disease
[D-Pro4,D-Trp7,9,Nle11] Substance P (4-11) is a potent neurokinin NK1 antagonist. [D-Pro4,D-Trp7,9,Nle11] Substance P (4-11) inhibits the effects of gold-protein-substance P (GPSP) and substance P (SP).

HY-107691

GR 159897	Neurokinin Receptor	Cancer Endocrinology Neurological Disease
GR 159897 is a highly potent, selective, competitive, brain-penetrated non-peptide neurokinin 2 (NK₂) receptor antagonist. GR 159897 has little or no affinity for NK₁ and NK₃ receptors. GR 159897 inhibits binding of [³H]GR100679 to human NK₂ (hNK₂)-CHO cells and rat colon membranes with pK_is of 9.51 and 10, respectively. Antagonizes bronchoconstriction. Anxiolytic-like and anti-tumor effects.

HY-150688

JAK3-IN-13	JNK	Cancer
JAK3-IN-13 is a potent, selective and orally active JAK3 inhibitor with IC₅₀ values of 4728, 2039, 8, 365 nM for NK1, JNK2, JNK3, Tyk2, respectively. JAK3-IN-13 shows antiproliferative activity. JAK3-IN-13 induces cell cycle arrest at G0/G1 phase. JAK3-IN-13 shows antitumor activity.

HY-P1722

Spantide II	Neurokinin Receptor	Inflammation/Immunology
Spantide II, an undecapeptide substance P (SP) analog, is a potent **neurokinin-1 receptor (NK-1R)** antagonist. Spantide II binds with NK-1R and blocks proinflammatory activities associated with SP. Spantide II can be used in the research of inflammatory skin disorders, such as psoriasis and contact dermatitis.

HY-14405B

(R)-Casopitant (R)-GW679769	Neurokinin Receptor	Cancer
(R)-Casopitant ((R)-GW679769) is the isomer of Casopitant (HY-14405). Casopitant is a NK(1)-receptor antagonist. Casopitant can be used for the research of chemotherapy-induced nausea and vomiting.

HY-P3854

GR 83074	Neurokinin Receptor	Neurological Disease
GR 83074 is a potent and selective NK-2 (Neurokinin Receptor) antagonist with a pK_B of 8.23. GR 83074 is inactive as an NK-3 antagonist and exhibits a 340-fold NK-2/NK-1 selectivity.

HY-19670

Befetupitant
Ro67-5930
Neurokinin Receptor Neurological Disease Endocrinology

Befetupitant is a high-affinity, nonpeptide, competitive tachykinin 1 receptor (NK1R) antagonist.

HY-P3852

Neurokinin Receptor (393-407), rat SPR393-407	Neurokinin Receptor	Inflammation/Immunology Neurological Disease
Neurokinin Receptor (393-407), rat (SPR393–407) is a rat *neurokinin 1 receptor (NK1R)* fragment. NK1R is rapidly internalized by endocytosis and recycled to the plasma membrane when binding to substance P (SP). Neurokinin Receptor (393-407), rat can be used in the research of neurogenic inflammation.

HY-114673

Benzomalvin B
Neurokinin Receptor Others

Benzomalvin B is the less active analogs of Benzomalvin A. Benzomalvin B is weakly active against substance P.

HY-P0242

Neurokinin B	Neurokinin Receptor	Neurological Disease Endocrinology
Neurokinin B belongs to the tachykinin family of peptides. Neurokinin B binds a family of GPCRs-including neurokinin receptor 1 (NK1R), NK2R, and NK3R-to mediate their biological effect.

HY-P0242A

Neurokinin B TFA	Neurokinin Receptor	Neurological Disease Endocrinology
Neurokinin B TFA belongs to the tachykinin family of peptides. Neurokinin B binds a family of GPCRs-including neurokinin receptor 1 (NK1R), NK2R, and NK3R-to mediate their biological effect.

HY-B2078A

Eprazinone dihydrochloride	Neurokinin Receptor	Inflammation/Immunology
Eprazinone dihydrochloride is a gent with mucolytic, secretolytic, antitussive, and bronchial antispasmodic properties. Eprazinone dihydrochloride is a neurokinin 1 receptor (NK1R) ligand. Eprazinone dihydrochloride has the potential for chronic bronchitis treatment that improved pulmonary function and arterial partial pressure of oxygen.

HY-P3801

[Glp5,(Me)Phe8,Sar9] Substance P (5-11) DiMe-C7	Neurokinin Receptor	Metabolic Disease Neurological Disease Others
[Glp5,(Me)Phe8,Sar9] Substance P (5-11) (DiMe-C7) is a Substance P (HY-P0201) analogue that has approximately the same effects as Substance P (HY-P0201) on neurokinin 1 receptor (NK1R) in rat brain, but with a much longer duration of action. [Glp5,(Me)Phe8,Sar9] Substance P (5-11) selectively activates dopamine metabolism in the mesencephalon and midbrain cortex of the rat brain. [Glp5,(Me)Phe8,Sar9] Substance P (5-11) also increases motor activity and induces recovery of cocaine-seeking behavior in rats.

Cat. No.	Product Name	Target	Research Area

HY-P1193

GR 82334	Peptides	Neurological Disease
GR 82334 is a potent and specific reversible *tachykinin NK1* receptor** antagonist. GR 82334 inhibits substance P-induced sensitization by blocking SP NK1 receptors in naked mole-rats.

HY-P2000

Septide
(Pyr6,Pro9)-Substance P
Neurokinin Receptor Neurological Disease

Septide ((Pyr6,Pro9)-Substance P) is a potent NK1 receptor agonist with a K_d value of 0.55 nM.

HY-P3891

Substance P (4-11)	Neurokinin Receptor	Neurological Disease
Substance P (4-11), the C-terminus fragment of Substance P (Substance P (HY-P0201)), is a Substance P agonist that shows highly selective for **NK1 receptors**.

HY-P1192

GR-73632	Neurokinin Receptor	Neurological Disease Endocrinology
GR-73632 is a novel tachykinin neurokinin 1 (NK-1) receptor agonist. GR-73632 acts directly on the peripheral terminals of primary sensory neurons through NK1 receptor which convey itch signals.

HY-P1738

[Sar9] Substance P
Neurokinin Receptor Neurological Disease Endocrinology

[Sar9] Substance P is a potent and selective neurokinin (NK)-1 receptor agonist.
HY-P0061

Vapreotide
RC160; BMY 41606
Neurokinin Receptor Cancer

Vapreotide is a neurokinin-1 (NK1) receptor antagonist, with an IC₅₀ of 330 nM.

HY-P0201

Substance P Neurokinin P	Neurokinin Receptor Endogenous Metabolite	Neurological Disease Endocrinology Cancer
Substance P (Neurokinin P) is a neuropeptide, acting as a neurotransmitter and as a neuromodulator in the CNS. The endogenous receptor for substance P is neurokinin 1 receptor (NK1-receptor, *NK1R*).

HY-P2475

[Pro9]-Substance P
Neurokinin Receptor Neurological Disease

[Pro9]-Substance P is a potent, reversible and selective agonist of NK-1 tachykinin receptors with an EC₅₀ of 0.93 nM.

HY-P0201A

Substance P TFA Neurokinin P TFA	Neurokinin Receptor Endogenous Metabolite	Endocrinology Neurological Disease Cancer
Substance P TFA (Neurokinin P TFA) is a neuropeptide, acting as a neurotransmitter and as a neuromodulator in the CNS. The endogenous receptor for substance P is neurokinin 1 receptor (NK1-receptor, *NK1R*).

HY-P1194A

Spantide I TFA	Neurokinin Receptor	Inflammation/Immunology
Spantide I TFA, a substance P analog, is a selective NK₁ receptor antagonist, with K_i values of 230 nM and 8150 nM for NK₁ and NK₂ receptor, respectively. Spantide I provides an approach to reduce type 1 and enhance the type 2 cytokine IL-10 in the infected cornea, leading to a significant reduction in corneal perforation.

HY-P1194

Spantide I	Neurokinin Receptor	Inflammation/Immunology
Spantide I, a substance P analog, is a selective NK₁ receptor antagonist, with K_i values of 230 nM and 8150 nM for NK₁ and NK₂ receptor, respectively. Spantide I provides an approach to reduce type 1 and enhance the type 2 cytokine IL-10 in the infected cornea, leading to a significant reduction in corneal perforation.

HY-P0061A

Vapreotide acetate RC-160 acetate; BMY-41606 acetate	Neurokinin Receptor	Cancer
Vapreotide acetate (RC-160 acetate; BMY-41606 acetate) is a neurokinin-1 (NK1) receptor antagonist, with an IC₅₀ of 330 nM.

HY-P3092

Phyllomedusin	Neurokinin Receptor	Neurological Disease
Phyllomedusin, an tachykinin decapeptide, is a NK1 receptor agonist. Phyllomedusin has vasodilating activity and provokes the contraction of the pylorus.

HY-P1012

[Sar9,Met(O2)11]-Substance P
Neurokinin Receptor Neurological Disease Endocrinology

[Sar9,Met(O2)11]-Substance P is a tachykinin NK₁ receptor selective agonist.

HY-P2546

Biotin-Substance P	Neurokinin Receptor	Neurological Disease
Biotin-Substance P is the biotin tagged Substance P. Substance P (Neurokinin P) is a neuropeptide, acting as a neurotransmitter and as a neuromodulator in the CNS. The endogenous receptor for substance P is neurokinin 1 receptor (NK1-receptor, NK1R).

HY-P1012A

[Sar9,Met(O2)11]-Substance P TFA
Neurokinin Receptor Neurological Disease Endocrinology

[Sar9,Met(O2)11]-Substance P TFA is a tachykinin NK₁ receptor selective agonist.

HY-P3890

Substance P (5-11)	Neurokinin Receptor	Neurological Disease
Substance P (5-11), the C-terminal heptapeptide of Substance P (Substance P (HY-P0201)), is a neuropeptide. Substance P (5-11) binds to **NK-1 tachykinin receptor**.

HY-P1030

Hemokinin 1 (mouse)	Neurokinin Receptor	Endocrinology
Hemokinin 1 (mouse) is a selective agonist of neurokinin-1 receptor, with K_i of 0.175 nM and 560 nM for human NK1 receptor and human NK2 receptor, respectively.

HY-P3802

[D-Trp2,7,9] Substance P	Neurokinin Receptor	Neurological Disease
[D-Trp2,7,9] Substance P is a tachykinin (Neurokinin Receptor) antagonist with K_i values of 1 μM, 1.3 μM, and ~9 μM for *NK-1, NK-2,and NK-3* receptor, respectively.

HY-P3889

Substance P (6-11)	Neurokinin Receptor	Neurological Disease
Substance P (6-11) is the C-terminal hexapeptideamide of Substance P (Substance P (HY-P0201)). Substance P (6-11) binds to NK-1 tachykinin receptor. Substance P (6-11) shows depolarization of motoneurons and a hypotensive effect.

HY-P1277

GR 94800	Neurokinin Receptor	Neurological Disease
GR 94800 is a potent and selective NK₂ receptor peptide antagonist, with pK_B values of 9.6, 6.4 and 6.0 for NK₂, NK₁ and NK₃ receptors, respectively.

HY-P1277A

GR 94800 TFA	Neurokinin Receptor	Neurological Disease
GR 94800 TFA is a potent and selective NK₂ receptor peptide antagonist, with pK_B values of 9.6, 6.4 and 6.0 for NK₂, NK₁ and NK₃ receptors, respectively.

HY-P3881

(D-Arg1,D-Pro2,D-Phe7,D-His9)-Substance P
Neurokinin Receptor Neurological Disease

(D-Arg1,D-Pro2,D-Phe7,D-His9)-Substance P is a selective NK₁ receptor antagonist.

HY-151413

MEN 10207	Neurokinin Receptor	Neurological Disease
MEN 10207 is a selective NK-2 tachykinin receptor (Neurokinin Receptor) antagonist. MEN 10207 has pA₂ values of 5.2, 7.9 and 4.9 in three monoreceptor in vitro assays for NK-1, NK-2 and NK-3 tachykinin receptors, respectively.

HY-P1278A

GR 64349 TFA	Neurokinin Receptor	Neurological Disease
GR 64349 is a potent and highly selective NK₂ receptor peptide antagonist, with an EC₅₀ of 3.7 nM in rat colon. GR 64349 exhibits selectivity >1000 and >300-fold with respect to NK₁ and NK₃ receptors, respectively.

HY-P1278

GR 64349	Neurokinin Receptor	Neurological Disease
GR 64349 is a potent and highly selective NK₂ receptor peptide antagonist, with an EC₅₀ of 3.7 nM in rat colon. GR 64349 exhibits selectivity >1000 and >300-fold with respect to NK₁ and NK₃ receptors, respectively.

HY-P1198

Hemokinin 1, human	Neurokinin Receptor	Neurological Disease
Hemokinin 1, human is a selective tachykinin neurokinin 1 (NK1) receptor full agonist. Hemokinin 1, human is a full agonist at NK2 and NK3 receptor. Hemokinin 1, human can produces an opioid-independent analgesia.

HY-P1198A

Hemokinin 1, human TFA	Neurokinin Receptor	Neurological Disease
Hemokinin 1, human TFA is a selective tachykinin neurokinin 1 (NK1) receptor full agonist. Hemokinin 1, human TFA is a full agonist at NK2 and NK3 receptor. Hemokinin 1, human TFA can produces an opioid-independent analgesia.

HY-P3805

[D-Pro4,D-Trp7,9,Nle11] Substance P (4-11)	Neurokinin Receptor	Neurological Disease Cardiovascular Disease
[D-Pro4,D-Trp7,9,Nle11] Substance P (4-11) is a potent neurokinin NK1 antagonist. [D-Pro4,D-Trp7,9,Nle11] Substance P (4-11) inhibits the effects of gold-protein-substance P (GPSP) and substance P (SP).

HY-P1722

Spantide II	Neurokinin Receptor	Inflammation/Immunology
Spantide II, an undecapeptide substance P (SP) analog, is a potent **neurokinin-1 receptor (NK-1R)** antagonist. Spantide II binds with NK-1R and blocks proinflammatory activities associated with SP. Spantide II can be used in the research of inflammatory skin disorders, such as psoriasis and contact dermatitis.

HY-P3854

GR 83074	Neurokinin Receptor	Neurological Disease
GR 83074 is a potent and selective NK-2 (Neurokinin Receptor) antagonist with a pK_B of 8.23. GR 83074 is inactive as an NK-3 antagonist and exhibits a 340-fold NK-2/NK-1 selectivity.

HY-P3852

Neurokinin Receptor (393-407), rat SPR393-407	Neurokinin Receptor	Inflammation/Immunology Neurological Disease
Neurokinin Receptor (393-407), rat (SPR393–407) is a rat *neurokinin 1 receptor (NK1R)* fragment. NK1R is rapidly internalized by endocytosis and recycled to the plasma membrane when binding to substance P (SP). Neurokinin Receptor (393-407), rat can be used in the research of neurogenic inflammation.

HY-P0242

Neurokinin B	Neurokinin Receptor	Neurological Disease Endocrinology
Neurokinin B belongs to the tachykinin family of peptides. Neurokinin B binds a family of GPCRs-including neurokinin receptor 1 (NK1R), NK2R, and NK3R-to mediate their biological effect.

HY-P0242A

Neurokinin B TFA	Neurokinin Receptor	Neurological Disease Endocrinology
Neurokinin B TFA belongs to the tachykinin family of peptides. Neurokinin B binds a family of GPCRs-including neurokinin receptor 1 (NK1R), NK2R, and NK3R-to mediate their biological effect.

HY-P3801

[Glp5,(Me)Phe8,Sar9] Substance P (5-11) DiMe-C7	Neurokinin Receptor	Metabolic Disease Neurological Disease Others
[Glp5,(Me)Phe8,Sar9] Substance P (5-11) (DiMe-C7) is a Substance P (HY-P0201) analogue that has approximately the same effects as Substance P (HY-P0201) on neurokinin 1 receptor (NK1R) in rat brain, but with a much longer duration of action. [Glp5,(Me)Phe8,Sar9] Substance P (5-11) selectively activates dopamine metabolism in the mesencephalon and midbrain cortex of the rat brain. [Glp5,(Me)Phe8,Sar9] Substance P (5-11) also increases motor activity and induces recovery of cocaine-seeking behavior in rats.

Cat. No.	Product Name	Target	Research Area

HY-P99143

Anti-Mouse NK1.1 Antibody
Inhibitory Antibodies Inflammation/Immunology

Anti-Mouse NK1.1 Antibody is an anti-mouse NK1.1 IgG2a antibody inhibitor derived from host mouse.

Cat. No.	Product Name	Target	Category

HY-P0201

Substance P Neurokinin P	Neurokinin Receptor Endogenous Metabolite	Structural Classification Natural Products Endogenous metabolite Source classification Neurological Disease Disease Research Fields Classification of Application Fields Endocrinology
Substance P (Neurokinin P) is a neuropeptide, acting as a neurotransmitter and as a neuromodulator in the CNS. The endogenous receptor for substance P is neurokinin 1 receptor (NK1-receptor, *NK1R*).

HY-P0255

Physalaemin	Neurokinin Receptor	Phenols Ketones, Aldehydes, Acids Classification of Application Fields Disease Research Fields Endocrinology Neurological Disease Source classification Animals
Physalaemin, a non-mammalian tachykinin, binds selectively to *neurokinin-1* (NK1) receptor with high affinity.

HY-119552

Acetylaszonalenin LL-S490β	Endogenous Metabolite Neurokinin Receptor	Alkaloids Indole Alkaloids Source classification Microorganisms
Acetylaszonalenin, a prenylated indole derivative, is a fungal metabolite.Acetylaszonalenin is a potent **neurokinin-1 (NK1)** receptor antagonist. Acetylaszonalenin shows inhibition of [³H]-SP binding to human astrocytoma cells with a K_i of 170 μM.

HY-118463

Benzomalvin A	Neurokinin Receptor	Alkaloids Quinoline Alkaloids Source classification Microorganisms
Benzomalvin A is a potent antagonist of neurokinin receptor isolated from Penicillium sp. Benzomalvin A shows inhibitory activity against substance P with K_i values of 12, 42 and 43 μM at the guinea pig, rat and human neurokinin NK1 receptors, respectively.

HY-114673

Benzomalvin B	Neurokinin Receptor	Alkaloids Quinoline Alkaloids Classification of Application Fields Disease Research Fields Other Diseases Source classification Microorganisms
Benzomalvin B is the less active analogs of Benzomalvin A. Benzomalvin B is weakly active against substance P.

Species:	Human (3) Rhesus Macaque (1) Mouse (2)
Tag:	His (2) Fc (2)
Source:	HEK293 (6)

Cat. No.	Product Name	Species	Source

HY-P78253

CD160 Protein, Mouse (133a.a, HEK293, Fc)
CD160; BY55; BY55FLJ46513; NK1; NK28
Mouse HEK293
HY-P78403

CD160 Protein, Human (HEK293, His-Avi)
CD160; BY55; BY55FLJ46513; NK1; NK28
Human HEK293

HY-P70114

B3GAT1 Protein, Human (HEK293, His) rHuGalactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1/B3GAT1, His; B3GAT1; Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1; beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P); CD57; GlcAT-P; HNK1; NK1; NK-1	Human	HEK293

HY-P75441

CD160 Protein, Mouse (159a.a, HEK293, Fc)
CD160 antigen; CD160
Mouse HEK293
HY-P75442

CD160 Protein, Human (158a.a, HEK293, His)
CD160 antigen; CD160
Human HEK293
HY-P76775

CD160 Protein, Rhesus Macaque (HEK293)
CD160 antigen; CD160
Rhesus Macaque HEK293

Cat. No.	Product Name

HY-16346S

Netupitant-d6

Netupitant-d₆ is the deuterium labeled Netupitant (CID-6451149), which is a highly potent and selective, orally active neurokinin-1 (NK1) receptor antagonist[1].

HY-10053S1

Maropitant-13C,d3
Maropitant-¹³C,d₃ is the ¹³C- and deuterium labeled Maropitant. Maropitant is a selective and orally active neurokinin (NK1) receptor antagonist. Maropitant acts by blocking the binding of substance P within the emetic center and the chemoreceptor trigger zone (CRTZ). Maropitant is highly effective in preventing vomiting[1][2].

NK1

Inhibitors & Agonists

Peptides

Inhibitory Antibodies

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