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Results for "

NNMT

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Small Interfering RNA (siRNA) (1)
By Research Areas:	Cancer (5) Cardiovascular Disease (1) Metabolic Disease (9) Neurological Disease (2)

12

Inhibitors & Agonists

2

Recombinant Proteins

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

NNMT-IN-3	Others	Metabolic Disease Cancer
NNMT-IN-3 (compound 14) is a potent and selective nicotinamide N-methyltransferase *NNMT* inhibitor with IC₅₀ values of 1.1 nM and 0.4 μM in cell-free and cell-based assays, respectively. NNMT-IN-3 can be used to research obesity, type 2 diabetes, alcohol-related liver disease, cancer, sarcopenia and so on .

HY-132890

NNMT-IN-2

Others Cancer

NNMT-IN-2 is a potent NNMT inhibitor with an IC₅₀ value of 3.7 nM.

NNMT-IN-4	Others	Cancer
NNMT-IN-4 (compound 38) is a selective, uncompetitive and membrane permeability nicotinamide N-methyltransferase (NNMT) inhibitor with IC₅₀ values of 42 and 38 nM in vitro biochemical and cell-based assays, respectively. NNMT-IN-4 shows favorable PK/PD and safety profiles as well as excellent oral bioavailability and pharmaceutical properties. NNMT-IN-4 can be used as a vivo chemical probe of NNMT .

NNMT-IN-5	Others	Neurological Disease Metabolic Disease Cancer
NNMT-IN-5 (Compound 3-12) is a potent nicotinamide N-methyltransferase (NNMT) inhibitor (IC₅₀ = 47.9 ± 0.6 nM). NNMT-IN-5 also has an excellent selectivity profile over a panel of human methyltransferases. NNMT-IN-5 can be used for the research of cancer, diabetes, metabolic disorders, and neurodegenerative diseases .

NNMT Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
NNMT Human Pre-designed siRNA Set A contains three designed siRNAs for NNMT gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

NNMT Human Pre-designed siRNA Set A NNMT Human Pre-designed siRNA Set A

NNMTi 1 Publications Verification	Others	Metabolic Disease
NNMTi is a potent nicotinamide N-methyltransferase (NNMT) inhibitor (IC₅₀=1.2 μM) and selectively binds to the NNMT substrate-binding site residues . NNMTi promotes myoblast differentiation in vitro and enhances fusion and regenerative capacity of muscle stem cells (muSCs) in aged mice .

JBSNF-000028 free base	Others	Metabolic Disease
JBSNF-000028 is an orally active nicotinamide N-methyltransferase (NNMT) inhibitor with IC₅₀s of 0.033 µM, 0.19 µM and 0.21 µM against human NNMT (hNNMT), monkey NNMT (mkNNMT), and mouse NNMT (mNNMT), respectively. JBSNF-000028 can be used for the research of metabolic disorders .

JBSNF-000028 hydrochloride	Others	Metabolic Disease
JBSNF-000028 hydrochloride is an orally active nicotinamide N-methyltransferase (NNMT) inhibitor with IC₅₀s of 0.033 μM, 0.19 μM and 0.21 μM against human NNMT (hNNMT), monkey NNMT (mkNNMT), and mouse NNMT (mNNMT), respectively. JBSNF-000028 hydrochloride can be used for the research of metabolic disorders .

JBSNF-000028 TFA	Others	Metabolic Disease
JBSNF-000028 TFA is an orally active nicotinamide N-methyltransferase (NNMT) inhibitor with IC₅₀s of 0.033 μM, 0.19 μM and 0.21 μM against human NNMT (hNNMT), monkey NNMT (mkNNMT), and mouse NNMT (mNNMT), respectively. JBSNF-000028 TFA can be used for the research of metabolic disorders .

HY-128464

LL320

Others Metabolic Disease

LL320 is a selective NNMT inhibitor with a K_i,app of 6.8 nM. LL320 exhibits interactions with RNMT, DPH₅, and SAHH .

II399	Others	Cardiovascular Disease Neurological Disease Metabolic Disease Cancer
II399 is a potent, selective *NNMT* bisubstrate inhibitor containing an unconventional SAM mimic, with a K_i of 5.9 nM. II399 exhibits an explicit pattern of competitive inhibition for NAM. II399 occupies both the substrate and cofactor binding pockets. II399 has the potential for the research of cancers, metabolic, cardiovascular, and neurodegenerative diseases .

JBSNF-000088 3 Publications Verification 6-Methoxynicotinamide	Others	Metabolic Disease
JBSNF-000088 (6-Methoxynicotinamide), a analog of nicotinamide (NA), is a potent and orally active Nicotinamide N-methyltransferase (NNMT) inhibitor with IC₅₀s of 1.8 µM, 2.8 µM, and 5.0 µM for human NNMT, monkey NNMT and mouse NNMT, respectively. JBSNF-000088 inhibits NNMT activity, reduces MNA levels and drives insulin sensitization, glucose modulation and body weight reduction in animal models of metabolic disease .

Species:	Human (2)
Tag:	His (1) GST (1)
Source:	E. coli (2)

Cat. No.	Compare	Product Name	Species	Source

	*Nicotinamide N-Methyltransferase/NNMT* Protein, Human (His)** Nicotinamide N-methyltransferase; NNMT	Human	E. coli
	The nicotinamide N-methyltransferase (NNMT) protein catalyzes the methylation of nicotinamide using S-adenosyl-L-methionine to form N1-methylnicotinamide. NNMT affects pluripotent embryonic stem cell development and acts as a metabolic regulator, affecting adipose tissue energy expenditure, gluconeogenesis, and cholesterol biosynthesis. Nicotinamide N-Methyltransferase/NNMT Protein, Human (His) is the recombinant human-derived Nicotinamide N-Methyltransferase/NNMT protein, expressed by E. coli , with C-His labeled tag. The total length of Nicotinamide N-Methyltransferase/NNMT Protein, Human (His) is 264 a.a., with molecular weight of ~25-30 kDa.

	NNMT Protein, Human (GST) Nicotinamide N-methyltransferase; EC:2.1.1.1; NNMT	Human	E. coli
	The nicotinamide N-methyltransferase (NNMT) protein catalyzes the methylation of nicotinamide using S-adenosyl-L-methionine to form N1-methylnicotinamide. NNMT affects pluripotent embryonic stem cell development and acts as a metabolic regulator, affecting adipose tissue energy expenditure, gluconeogenesis, and cholesterol biosynthesis. NNMT Protein, Human (GST) is the recombinant human-derived NNMT protein, expressed by E. coli , with N-GST labeled tag. The total length of NNMT Protein, Human (GST) is 264 a.a., with molecular weight of 56.6 kDa.

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