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NOD-SCID

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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-149428
    AD4
    1 Publications Verification

    		 PROTACs Cancer
    AD4 is an artemisinin derivative that is a proteolytic targeting chimera (PROTAC) targeting PCLAF. AD4 can effectively degrade PCLAF in RS4;11 cells (IC50: 0.6 nM), thereby activating the p21/Rb axis and exerting anti-tumor activity. AD4 also prolonged survival of RS4;11-transplanted NOD/SCID mice, with in vivo efficacy .
    AD4
  • HY-143471
    PLK1/BRD4-IN-1

    		Polo-like Kinase (PLK) Epigenetic Reader Domain Apoptosis Cancer
    PLK1/BRD4-IN-1 (9b) is an orally active dual PLK1 and BRD4 inhibitor with IC50 values of 22 nM and 109 nM against PLK1 and BRD4, respectively. PLK1/BRD4-IN-1 induces cell cycle arrest and apoptosis, downregulates the transcription of several proliferation-related oncogenes, and exhibits favorable in vivo antitumor activity .
    PLK1/BRD4-IN-1
  • HY-161409
    SC912

    		Androgen Receptor Apoptosis
    SC912 is an AR-NTD inhibitor. SC912 possesses safety, potency and selectivity. SC912 binds directly to AR-FL and AR-V7 proteins. SC912 exerts anticancer activity through inhibition of proliferation, induction of cell cycle arrest and apoptosis.(AR-V7 IC50 = 0.36 μM )
    SC912

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