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NTPDase

" in MedChemExpress (MCE) Product Catalog:

By Targets:	NTPDase (1) Cytochrome P450 (1) Interleukin Related (1) Isotope-Labeled Compounds (1) P2X Receptor (1) P2Y Receptor (1) Phosphatase (14) Pyroptosis (1)
By Research Areas:	Cancer (9) Cardiovascular Disease (7) Infection (2) Inflammation/Immunology (9) Metabolic Disease (1) Neurological Disease (3)

Inhibitors & Agonists

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Targets Recommended: NTPDase

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-155828

*h-NTPDase-IN-4*	Phosphatase	Cancer
h-NTPDase-IN-4 (compound 4c) is a pan-inhibitor of NTPDase with IC50s of 3.58 μM (h-NTPDase1), 10.21 μM (h-NTPDase2), 0.13 μM (h-NTPDase3), 13.57 μM (h- NTPDase8).

HY-143289

NTPDase-IN-3	Phosphatase	Cardiovascular Disease Cancer
NTPDase-IN-3 (Compound 5e) is a *NTPDase* inhibitor, with IC₅₀ values of: 0.38 μM (NTPDase3), 0.05 μM (NTPDase8), 0.21 μM (NTPDase1), and 1.07 μM (NTPDase2). NTPDase-IN-3 can be used in the research of cancers and thrombosis .

HY-143288

NTPDase-IN-2	Phosphatase	Infection Inflammation/Immunology Cancer
NTPDase-IN-2 (compound 5g) is a selective *NTPDase* inhibitor with IC₅₀s of 0.04 and 2.27 µM for *h-NTPDase-2/-8, respectively. NTPDase-IN-2 non-competitively inhibits h-NTPDase-1/-2* with a K_m of 74 µM for *h-NTPDase-2. NTPDase*-IN-2 can be used in studies of cancer, immunologic disorders as well as bacterial infections .

HY-143287

NTPDase-IN-1	Phosphatase	Infection Inflammation/Immunology Cancer
NTPDase-IN-1 (compound 5a) is a selective *NTPDase* inhibitor with IC₅₀s of 0.05, 0.23 and 0.54 µM for *h-NTPDase-1/-2/-8, respectively. NTPDase-IN-1 non-competitively inhibits h-NTPDase-1/-2* with a K_m of 21 µM for *h-NTPDase-1. NTPDase*-IN-1 can be used in studies of cancer, immunologic disorders as well as bacterial infections .

HY-155596

*h-NTPDase-IN-1*	Phosphatase	Cancer
h-NTPDase-IN-1 (Compound 3i) is a *h-NTPDase* inhibitor (IC₅₀: 2.88 μM and 0.72 μM for h-NTPDase1 and h-NTPDase3 respectively). h-NTPDase-IN-1 can be used for research of thrombosis, inflammation, diabetes, and cancer .

HY-155829

*h-NTPDase-IN-5*	Phosphatase	Others
h-NTPDase-IN-5 (compound 3b) is a pan-inhibitor of NTPDase with IC50s of 1.10 μM (h-NTPDase1), 44.73 μM (h-NTPDase2), 26.14 μM (h-NTPDase3), 0.32 μM (h- NTPDase8).

HY-155827

*h-NTPDase-IN-3*	Phosphatase	Others
h-NTPDase-IN-3 (compound 4d) is a pan-inhibitor of NTPDase with IC50s of 34.13 μM (h-NTPDase1), 0.33 μM (h-NTPDase2), 23.21 μM (h-NTPDase3), 2.48 μM (h- NTPDase8).

HY-155806

*h-NTPDase-IN-2*	Phosphatase	Others
h-NTPDase-IN-2 (compound 3l) is a pan-inhibitor of h-NTPDase, with IC₅₀s of 0.35 μM (h-NTPDase1), 4.81 μM (h-NTPDase2), 37.73 μM (h-NTPDase3), 10.32 μM (h-NTPDase8), respectively .

HY-155597

*h-NTPDase8-IN-1*	Phosphatase	Metabolic Disease Inflammation/Immunology Cancer
h-NTPDase8-IN-1 (compound 2d) is a sulfamoyl-benzamides based and selective inhibitor for h-NTPDases8 (IC₅₀=0.28 μM). h-NTPDases8 is involved in a variety of physiological and pathological functions，such as thrombosis，diabetes，inflammation，and cancer .

HY-103263

PSB-06126	Phosphatase	Cardiovascular Disease Neurological Disease Inflammation/Immunology Cancer
PSB-06126 is a selective nucleoside triphosphate diphosphohydrolase (NTPDase) inhibitor, with the K_i values of 0.33 μM for rat NTPDase 1, 19.1 μM for NTPDase 2 and 2.22 μM for NTPDase 3, respectively. PSB-06126 acts on human NTPDase 3 with an IC₅₀ value of 7.76 μM and a K_i value of 4.39 μM .

HY-103265

ARL67156 trisodium 2 Publications Verification FPL 67156 trisodium	Phosphatase	Cardiovascular Disease Inflammation/Immunology
ARL67156 (FPL 67156) trisodium is a selective small molecular inhibitor, targeting to ecto-ATPase, CD39, and CD73. ARL67156 trisodium is also a competitive inhibitor of NTPDase1 (CD39), NTPDase3 and NPP1, with K_is of 11, 18 and 12?μM, respectively. ARL67156 trisodium can be used in the research of calcific aortic valve disease, asthma .

HY-103265B

ARL67156 trisodium hydrate 2 Publications Verification FPL 67156 trisodium hydrate	Phosphatase	Cardiovascular Disease Inflammation/Immunology
ARL67156 (FPL 67156) trisodium hydrate is a selective small is a selective samll molecular inhibitor, targeting to ecto-ATPase, CD39, and CD73. ARL67156 trisodium hydrate is also a competitive inhibitor of NTPDase1 (CD39), NTPDase3 and NPP1, with K_is of 11, 18 and 12?μM, respectively. ARL67156 trisodium hydrate can be used in the research of disease like calcific aortic valve disease, asthma .

HY-103265D

ARL67156 triethylamine 2 Publications Verification FPL 67156 triethylamine	Phosphatase	Cardiovascular Disease Inflammation/Immunology
ARL67156 (FPL 67156) triethylamine is a selective small is a selective samll molecular inhibitor, targeting to ecto-ATPase, CD39, and CD73. ARL67156 triethylamine is also a competitive inhibitor of NTPDase1 (CD39), NTPDase3 and NPP1, with K_is of 11, 18 and 12?μM, respectively. ARL67156 triethylamine can be used in the research of disease like calcific aortic valve disease, asthma .

HY-103259

Sodium metatungstate 5 Publications Verification Sodium polyoxotungstate; POM-1	Phosphatase P2X Receptor P2Y Receptor Pyroptosis Interleukin Related	Neurological Disease Inflammation/Immunology Cancer
Sodium metatungstate (Sodium polyoxotungstate) is a *NTPDase* inhibitor, with K_i values of 2.58 μM, 3.26 μM, and 28.8 μM for NTPDase 1 (CD39), NTPDase 3 and NTPDase 2 respectively . Sodium metatungstate has anti-inflammatory and anti-cancer effect. Sodium metatungstate inhibits ATP breakdown but also blocks central synaptic transmission .

HY-100386

Ticlopidine PCR 5332
Ticlopidine (PCR 5332), an antithrombotic proagent, acts as an allosteric, noncompetitive inhibitor of CD39 with the IC50 of 81.7 μM. Ticlopidine blocks several NTPDase isoenzymes with IC50s of 170 μM and 149 μM for NTPDase2 and NTPDase3, respectively. Ticlopidine is an inhibitor of CYP2C19 human liver cytochrome. Ticlopidine inhibits CYP2C9 and CYP3A4 with IC50s of 26.0 and 32.3 μM, respectively.

HY-100386S

Ticlopidine-d4 PCR 5332-d₄	Isotope-Labeled Compounds Cytochrome P450	Cardiovascular Disease
Ticlopidine-d4 is the deuterium labeled Ticlopidine. Ticlopidine (PCR 5332), an antithrombotic proagent, acts as an allosteric, noncompetitive inhibitor of CD39 with the IC50 of 81.7 μM. Ticlopidine blocks several NTPDase isoenzymes with IC50s of 170 μM and 149 μM for NTPDase2 and NTPDase3, respectively[1]. Ticlopidine is an inhibitor of CYP2C19 human liver cytochrome. Ticlopidine inhibits CYP2C9 and CYP3A4 with IC50s of 26.0 and 32.3 μM, respectively[2][3].

HY-103262

PSB069	NTPDase	Cardiovascular Disease Neurological Disease Inflammation/Immunology Cancer
PSB069 bearing a p-chlorophenylamino residue is a potent, well-tolerated and nonselective NTPDases1, 2, 3 inhibitor(K_i=16~18 μM) .

Species:	Human (4) Rhesus Macaque (1) Mouse (3)
Tag:	His (8)
Source:	HEK293 (1) Sf9 insect cells (7)

Cat. No.	Compare	Product Name	Species	Source

HY-P70727

	CD39 Protein, Mouse (HEK293, His) Ectonucleoside triphosphate diphosphohydrolase 1; NTPDase 1; NTPDase 1; Ecto-ATP diphosphohydrolase 1; Ecto-ATPDase 1; Ecto-ATPase 1; Ecto-apyrase; Lymphoid cell activation antigen; CD39	Mouse	HEK293
	The CD39 protein, expressed in the nervous system, regulates purinergic neurotransmission by hydrolyzing ATP and other nucleotides. It also prevents platelet aggregation by hydrolyzing platelet-activating ADP to AMP. CD39's proficiency in hydrolyzing both ATP and ADP underscores its versatile role in modulating purinergic signaling, influencing neurotransmission and platelet function. Its dual enzymatic activity maintains the delicate balance of purinergic signaling in the nervous system and hemostasis. CD39 Protein, Mouse (HEK293, His) is the recombinant mouse-derived CD39 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of CD39 Protein, Mouse (HEK293, His) is 441 a.a., with molecular weight of 60-90 kDa.

HY-P72731

	CD39 Protein, Human (Baculovirus, His) Ectonucleoside triphosphate diphosphohydrolase 1; NTPDase 1; CD39; ENTPD1	Human	Sf9 insect cells
	The CD39 protein is an important regulator in the nervous system, coordinating purinergic neurotransmission by hydrolyzing ATP and other nucleotides. Its enzymatic ability can hydrolyze platelet-activated ADP into AMP, thereby effectively preventing platelet aggregation. CD39 Protein, Human (Baculovirus, His) is the recombinant human-derived CD39 protein, expressed by Sf9 insect cells , with C-6*His labeled tag. The total length of CD39 Protein, Human (Baculovirus, His) is 441 a.a., with molecular weight of ~60 kDa.

HY-P72898

	CD39 Protein, Mouse (His) Ectonucleoside triphosphate diphosphohydrolase 1; NTPDase 1; Ecto-apyrase; CD39; Entpd1	Mouse	Sf9 insect cells
	The CD39 protein is expressed in the nervous system and regulates purinergic neurotransmission by hydrolyzing ATP and other nucleotides. It also prevents platelet aggregation by hydrolyzing platelet-activated ADP to AMP. CD39 Protein, Mouse (His) is the recombinant mouse-derived CD39 protein, expressed by Sf9 insect cells , with C-His labeled tag. The total length of CD39 Protein, Mouse (His) is 441 a.a., with molecular weight of ~51 kDa.

HY-P76905

	ENTPD5 Protein, Human (sf9, His) Ectonucleoside triphosphate diphosphohydrolase 5; NTPDase 5; CD39L4; PCPH	Human	Sf9 insect cells
	The ENTPD5 protein is located in the lumen of the endoplasmic reticulum and plays a crucial role in glycoprotein processing by preferentially hydrolyzing nucleoside diphosphates, including GDP, IDP, and UDP. Its enzymatic activity ensures the clearance of UDP, an end-product feedback inhibitor of UDP-Glc:glycoprotein glucosyltransferase. ENTPD5 Protein, Human (sf9, His) is the recombinant human-derived ENTPD5 protein, expressed by Sf9 insect cells , with C-His labeled tag. The total length of ENTPD5 Protein, Human (sf9, His) is 428 a.a., with molecular weight of ~45 kDa.

HY-P75417

	CD39 Protein, Human (sf9, His) Ectonucleoside triphosphate diphosphohydrolase 1; NTPDase 1; Ecto-apyrase; CD39; Entpd1	Human	Sf9 insect cells
	The CD39 protein is an important regulator in the nervous system, coordinating purinergic neurotransmission by hydrolyzing ATP and other nucleotides. Its enzymatic ability can hydrolyze platelet-activated ADP into AMP, thereby effectively preventing platelet aggregation. CD39 Protein, Human (sf9, His) is the recombinant human-derived CD39 protein, expressed by Sf9 insect cells , with C-His labeled tag. The total length of CD39 Protein, Human (sf9, His) is 441 a.a., with molecular weight of ~51.8 kDa.

HY-P76801

	CD39 Protein, Cynomolgus/Rhesus Macaque (sf9, His) Ectonucleoside triphosphate diphosphohydrolase 1; NTPDase 1; Ecto-apyrase; CD39; Entpd1	Rhesus Macaque	Sf9 insect cells
	ENTPD1 is an integral membrane protein with an extracellular active site. ENTPD1 hydrolyzes the beta - and gamma phosphate residues of nucleotides, preferring ATP as the substrate. Through its hydrolysis of extracellular nucleotides, ENTPD1 plays a role in the regulation of purinergic signaling. CD39 Protein, Cynomolgus/Rhesus Macaque (sf9, His) is the recombinant Rhesus Macaque-derived CD39 protein, expressed by Sf9 insect cells , with C-His labeled tag. The total length of CD39 Protein, Cynomolgus/Rhesus Macaque (sf9, His) is 441 a.a., with molecular weight of ~51.8 KDa.

HY-P76904

	ENTPD3 Protein, Human (sf9, His) Ectonucleoside triphosphate diphosphohydrolase 3; NTPDase 3; Ecto-apyrase 3; CD39L3	Human	Sf9 insect cells
	The ENTPD3 protein exhibits unique enzymatic preferences, with triple hydrolysis specificity for ATP hydrolysis and triple specificity for ADP hydrolysis. This shows a clear affinity for ATP substrate hydrolysis, suggesting a critical role in cellular processes involving the breakdown of ATP molecules. ENTPD3 Protein, Human (sf9, His) is the recombinant human-derived ENTPD3 protein, expressed by Sf9 insect cells , with C-His labeled tag. The total length of ENTPD3 Protein, Human (sf9, His) is 442 a.a., with molecular weight of ~50 kDa.

HY-P76317

	CD39L4/ENTPD5 Protein, Mouse (sf9, His) Ectonucleoside triphosphate diphosphohydrolase 5; NTPDase 5; CD39 antigen-like 4; CD39L4	Mouse	Sf9 insect cells
	The CD39L4/ENTPD5 protein is located in the lumen of the endoplasmic reticulum and plays a crucial role in glycoprotein processing by hydrolyzing nucleoside diphosphates (including GDP, IDP, and UDP). Its enzymatic activity is critical for the clearance of UDP, an end-product feedback inhibitor of UDP-Glc:glycoprotein glucosyltransferase. CD39L4/ENTPD5 Protein, Mouse (sf9, His) is the recombinant mouse-derived CD39L4/ENTPD5 protein, expressed by Sf9 insect cells , with C-His labeled tag. The total length of CD39L4/ENTPD5 Protein, Mouse (sf9, His) is 409 a.a., with molecular weight of ~45 KDa.


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Ticlopidine-d4
Ticlopidine-d4 is the deuterium labeled Ticlopidine. Ticlopidine (PCR 5332), an antithrombotic proagent, acts as an allosteric, noncompetitive inhibitor of CD39 with the IC50 of 81.7 μM. Ticlopidine blocks several NTPDase isoenzymes with IC50s of 170 μM and 149 μM for NTPDase2 and NTPDase3, respectively[1]. Ticlopidine is an inhibitor of CYP2C19 human liver cytochrome. Ticlopidine inhibits CYP2C9 and CYP3A4 with IC50s of 26.0 and 32.3 μM, respectively[2][3].

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