Search Result

Pathways Recommended:	Membrane Transporter/Ion Channel

Results for "

Na channels

" in MCE Product Catalog:

By Targets:	Calcium Channel (10) Na+/Ca2+ Exchanger (3) Na+/H+ Exchanger (NHE) (2) Potassium Channel (8) Sodium Channel (47) TRP Channel (2) 5-HT Receptor (1) Adrenergic Receptor (1) Amyloid-β (1) Apoptosis (1) Autophagy (9) Bacterial (1) COX (3) Dopamine Receptor (3) Endogenous Metabolite (1) ERK (1) G protein-coupled Bile Acid Receptor 1 (1) GABA Receptor (4) Guanylate Cyclase (1) HIV (1) iGluR (1) IKK (2) mAChR (1) NF-κB (2) Phosphodiesterase (PDE) (2) Prostaglandin Receptor (2) Serotonin Transporter (1) Thyroid Hormone Receptor (1) Virus Protease (4)
By Research Areas:	Cancer (11) Cardiovascular Disease (8) Endocrinology (1) Infection (1) Inflammation/Immunology (8) Metabolic Disease (4) Neurological Disease (37)

By Targets:

Calcium Channel (10)

Na+/Ca2+ Exchanger (3)

Na+/H+ Exchanger (NHE) (2)

Potassium Channel (8)

Sodium Channel (47)

TRP Channel (2)

5-HT Receptor (1)

Adrenergic Receptor (1)

Amyloid-β (1)

Apoptosis (1)

Autophagy (9)

Bacterial (1)

COX (3)

Dopamine Receptor (3)

Endogenous Metabolite (1)

ERK (1)

G protein-coupled Bile Acid Receptor 1 (1)

GABA Receptor (4)

Guanylate Cyclase (1)

HIV (1)

iGluR (1)

IKK (2)

mAChR (1)

NF-κB (2)

Phosphodiesterase (PDE) (2)

Prostaglandin Receptor (2)

Serotonin Transporter (1)

Thyroid Hormone Receptor (1)

Virus Protease (4)

By Research Areas:

Cancer (11)

Cardiovascular Disease (8)

Endocrinology (1)

Infection (1)

Inflammation/Immunology (8)

Metabolic Disease (4)

Neurological Disease (37)

Inhibitors & Agonists

Screening Libraries

Biochemical Assay Reagents

Peptides

Natural
Products

Isotope-Labeled Compounds

Targets Recommended: Sodium Channel Na+/HCO3- Cotransporter Na+/Ca2+ Exchanger Na+/K+ ATPase Na+/H+ Exchanger (NHE) NKCC Chloride Channel Calcium Channel HCN Channel CRAC Channel TRP Channel Potassium Channel Piezo Channel

Cat. No.	Product Name	Target	Research Areas

HY-131899

N-Bromoacetamide	Potassium Channel Sodium Channel	Others
N-Bromoacetamide can irreversibly remove sodium channel inactivation in the cytoplasmic face of the membrane, also decreasing K current rapid inactivation.

HY-19062

SM-6586	Calcium Channel Na+/Ca2+ Exchanger	Cardiovascular Disease
SM-6586 is a calcium channel antagonist and inhibitor of Na +/H⁺ and Na +/Ca²⁺ exchange transport, potentially for the treatment of cerebrovasular diseases and hypertension.

HY-135412

N-Methyl Duloxetine hydrochloride	Sodium Channel	Neurological Disease
N-Methyl Duloxetine hydrochloride is an analgesic. N-Methyl Duloxetine (hydrochloride) elicits both tonic and use-dependent block of neuronal Na + channels.

HY-12545

Brevetoxin-3 PbTx-3	Sodium Channel	Inflammation/Immunology
Brevetoxin-3 (PbTx-3) is a potent allosteric voltage-gated Na + channel activator and has multiple active centers (A-ring lactone, C-42 of R side chain). Brevetoxin-3 (PbTx-3) has a high affinity to site 5 of the voltage-sensitive Na + channels, inhibits the inactivation of Na + channels and prolongs the mean open time of these channels. Brevetoxin-3 (PbTx-3) repeated exposures can lead to prolonged airway hyperresponsiveness (AHR) and lung inflammation.

HY-N9404

6-Benzoylheteratisine
Sodium Channel Neurological Disease

6-Benzoylheteratisine is a naturally occurring antagonist of the Na + channel activator aconitine.

6-Benzoylheteratisine	Sodium Channel	Neurological Disease
6-Benzoylheteratisine is a naturally occurring antagonist of the Na + channel activator aconitine.

HY-16952A

Bepridil hydrochloride hydrate (±)-Bepridil hydrochloride hydrate; Org 5730 hydrochloride hydrate	Calcium Channel	Cardiovascular Disease
Bepridil hydrochloride hydrate ((±)-Bepridil hydrochloride hydrate) is a non-selective, long-acting Ca⁺ channel antagonist and Na +, K⁺ channel inhibitor, with antianginal and type I antiarrhythmic effects. Bepridil hydrochloride hydrate also acts as a cardiac Na +/Ca2⁺ exchange (NCX1) inhibitor. Bepridil hydrochloride hydrate can be used for the research of cardiovascular disorders.

HY-N0239

Bulleyaconitine A	Sodium Channel	Neurological Disease
Bulleyaconitine A is an analgesic and antiinflammatory drug isolated from Aconitum plants; has several potential targets, including voltage-gated Na+ channels.

HY-Y0258

Benzocaine	Sodium Channel Bacterial	Neurological Disease
Benzocaine shares a common receptor with all othe rLAs in the voltage-gated Na + channel, with an IC₅₀ of 0.8 mM tested with a potential of +30 mV.

HY-B0575

Triamterene	Sodium Channel G protein-coupled Bile Acid Receptor 1	Metabolic Disease
Triamterene blocks epithelial Na+ channel (ENaC) in a voltage-dependent manner, which used as a mild diuretic. Triamterene as an inhibitor of the TGR5 receptor.

HY-101362

QX-222 chloride
Sodium Channel Neurological Disease

QX-222 chloride, a trimethyl analogue of Lignocaine (HY-B0185), is a potent Na + channel blocker.

QX-222 chloride	Sodium Channel	Neurological Disease
QX-222 chloride, a trimethyl analogue of Lignocaine (HY-B0185), is a potent Na + channel blocker.

HY-B0211

Riluzole PK 26124	Sodium Channel GABA Receptor	Neurological Disease Cancer
Riluzole is an anticonvulsant agent and belongs to the family of use-dependent Na + channel blocker which can also inhibit GABA uptake with an IC₅₀ of 43 μM.

HY-B0211A

Riluzole hydrochloride PK 26124 hydrochloride	Sodium Channel GABA Receptor	Neurological Disease Cancer
Riluzole hydrochloride is an anticonvulsant agent and belongs to the family of use-dependent Na + channel blocker which can also inhibit GABA uptake with an IC₅₀ of 43 μM.

HY-108504

Co 102862 V 102862	Sodium Channel	Neurological Disease
Co 102862 (V 102862) is a potent, broad-spectrum, state-dependent Na + channel blocker. Co 102862 is also an orally active anticonvulsant.

HY-101437A

Ralfinamide mesylate FCE-26742A mesylate	Sodium Channel	Neurological Disease
Ralfinamide mesylate (FCE-26742A mesylate) is an orally available Na + channel blocker derived from α-aminoamide, with function of suppressing pain.

HY-112729

HC-056456 3,4-Bis(2-thienoyl)-1,2,5-oxadiazole-N-oxide	Calcium Channel	Others
HC-056456 is an effective but not perfectly-selective blocker of CatSper channels. The [Na +]_i rise is slowed by HC-056456 (IC₅₀~3 µM).

HY-B0575S

Triamterene-d5	Sodium Channel	Metabolic Disease
Triamterene-d₅ is deuterium labeled Triamterene, which can block epithelial Na+ channel (ENaC) in a voltage-dependent manner, which used as a mild diuretic.

HY-N11378

Parabuthus Granulatus Venom Granulated Thick-tailed Venom	Calcium Channel Sodium Channel	Neurological Disease
Parabuthus Granulatus Venom (Granulated Thick-tailed Venom) is a scorpion venom that can be obtained from Granulated Thick-tailed scorpion. Two scorpion toxins from the scorpion Parabuthus granulatus can inhibit voltage-gated Ca²⁺ and Na + channels.

HY-116790A

(+)-Penbutolol (R)-Penbutolol; (+)-Isopenbutolol	Adrenergic Receptor	Metabolic Disease Endocrinology
(+)-Penbutolol is a β-adrenoceptor antagonist, with an IC₅₀ of 0.74 μM. (+)-Penbutolol is an optical isomer of l-penbutolol with Na + channel-blocking action.

HY-P1073

ProTx-I	Calcium Channel Sodium Channel Potassium Channel	Cancer
ProTx-I, a venom toxin of the tarantula Thrixopelma pruriens, is a potent, selective Ca_V3.1 channel blocker with IC₅₀ values of 0.2 μM and 31.8 μM for hCa_V3.1 and hCa_V3.2 respectively. ProTx-I is also a potent blocker for voltage-gated Na + channels and inhibits K_V 2.1 channels.

HY-B0448A

Phenytoin sodium 5,5-Diphenylhydantoin sodium salt	Sodium Channel Virus Protease	Neurological Disease Cancer
Phenytoin sodium (5,5-Diphenylhydantoin sodium salt) is a potent *Voltage-gated Na + channels* (VGSCs)** blocker. Phenytoin has antiepileptic activity and reduces breast tumour growth and metastasis in mice.

HY-Y0258S

Benzocaine-d4	Sodium Channel	Neurological Disease
Benzocaine-d₄ is the deuterium labeled Benzocaine. Benzocaine shares a common receptor with all othe rLAs in the voltage-gated Na+ channel, with an IC50 of 0.8 mM tested with a potential of +30 mV.

HY-B0448

Phenytoin 5,5-Diphenylhydantoin	Sodium Channel Virus Protease	Neurological Disease Cancer
Phenytoin (5,5-Diphenylhydantoin) is a potent *Voltage-gated Na + channels* (VGSCs)** blocker. Phenytoin has antiepileptic activity and reduces breast tumour growth and metastasis in mice.

HY-14183

Vernakalant Hydrochloride RSD1235 hydrochloride	Potassium Channel	Cardiovascular Disease
Vernakalant hydrochloride is a mixed voltage- and frequency-dependent Na + and atria-preferred K⁺ channel blocker. IC₅₀ for block by Vernakalant of wild-type and mutant Kv1.5 channels Fractional block is 13.35±0.93 μM, 0.61±0.03 μM, and 1.63±0.09 μM for *Kv1.5 channel* wt, Kv1.5 channel I508F, Kv1.5 channel T479A**, respectively.

HY-Y0258S1

Benzocaine-(ethyl-d5)	Sodium Channel	Neurological Disease
Benzocaine-(ethyl-d₅) is the deuterium labeled Benzocaine. Benzocaine shares a common receptor with all othe rLAs in the voltage-gated Na+ channel, with an IC50 of 0.8 mM tested with a potential of +30 mV.

HY-107754

Cesium chloride	Potassium Channel	Cardiovascular Disease
Cesium chloride is a blocker of potassium channel. Cesium chloride prevents the decrease of Na + transport produced by Alloxan. Cesium chloride has induced cardiac arrhythmias, including torsade de pointes in animal models.

HY-100080

A-887826	Sodium Channel	Neurological Disease
A-887826 is a potent, selective, oral bioavailable and voltage-dependent Na(v)1.8 sodium channel blocker with an IC₅₀ of 11 nM . A-887826 attenuates neuropathic tactile allodynia in vivo.

HY-N6868

Dimethyl lithospermate B dmLSB	Sodium Channel	Cardiovascular Disease
Dimethyl lithospermate B (dmLSB) is a selective Na + channel agonist. Dimethyl lithospermate B slows inactivation of sodium current (INa), leading to increased inward current during the early phases of the action potential (AP).

HY-132133

Nav1.8-IN-1	Sodium Channel	Inflammation/Immunology Neurological Disease
Nav1.8-IN-1 (Compound 31) is a potent inhibitor of Na(v)1.8 sodium channel. Nav1.8-IN-1 has the potential for the research of inflammatory and neuropathic pain.

HY-B0358

Flunarizine	Calcium Channel Sodium Channel Dopamine Receptor	Neurological Disease
Flunarizine is a potent dual *Na +/Ca²⁺ channel* (T-type) blocker. Flunarizine is a D₂ dopamine** receptor antagonist. Flunarizine shows anticonvulsive and antimigraine activity, and peripheral vasodilator effects.

HY-B0358A

Flunarizine dihydrochloride	Calcium Channel Sodium Channel Dopamine Receptor	Neurological Disease
Flunarizine dihydrochloride is a potent dual *Na +/Ca²⁺ channel* (T-type) blocker. Flunarizine dihydrochloride is a D₂ dopamine** receptor antagonist. Flunarizine dihydrochloride shows anticonvulsive and antimigraine activity, and peripheral vasodilator effects.

HY-12596

JNJ-26489112	Calcium Channel Sodium Channel Potassium Channel	Neurological Disease
JNJ-26489112, a CNS-active agent, exhibits broad-spectrum anticonvulsant activity in rodents against audiogenic, electrically-induced, and chemically-induced seizures. JNJ-26489112 inhibits voltage-gated Na + channels and N-type Ca²⁺ channels, and is effective as a K⁺ channel opener. JNJ-26489112 has very weak inhibition of CA-II (IC₅₀=35 μM) and CA-I (18 μM).

HY-B0448S

Phenytoin-d10 5,5-Diphenylhydantoin-d₁₀	Sodium Channel Virus Protease	Neurological Disease
Phenytoin-d₁₀ is the deuterium labeled Phenytoin. Phenytoin (5,5-Diphenylhydantoin) is a potent Voltage-gated Na+ channels (VGSCs) blocker. Phenytoin has antiepileptic activity and reduces breast tumour growth and metastasis in mice[1][2].

HY-B0495A

Lamotrigine hydrate LTG hydrate; BW430C hydrate	Sodium Channel Autophagy	Neurological Disease
Lamotrigine hydrate is a potent and orally active anticonvulsant or antiepileptic agent. Lamotrigine hydrate selectively blocks voltage-gated Na + channels, stabilizing presynaptic neuronal membranes and inhibiting glutamate release. Lamotrigine hydrate can be used for the research of epilepsy, focal seizure, et al.

HY-107695

Remacemide hydrochloride FPL 12924AA	iGluR Sodium Channel	Neurological Disease
Remacemide hydrochloride (FPL 12924AA), a moderate inhibitor of the Na + channel, is a weak uncompetitive NMDA receptor antagonist with IC₅₀s of 68 μM and 76 μM for MK-801 binding and NMDA currents, respectively. Remacemide hydrochloride is an anticonvulsant agent.

HY-B0211S

Riluzole-13C,15N2 PK 26124-¹³C,¹⁵N₂	GABA Receptor Sodium Channel
Riluzole-¹³C,¹⁵N₂ is the ¹³C and ¹⁵N labeled Riluzole[1]. Riluzole is an anticonvulsant agent and belongs to the family of use-dependent Na+ channel blocker which can also inhibit GABA uptake with an IC50 of 43 μM[2][3].

HY-B0495

Lamotrigine LTG; BW430C	Sodium Channel Autophagy	Neurological Disease
Lamotrigine (BW430C) is a potent and orally active anticonvulsant or antiepileptic agent. Lamotrigine selectively blocks voltage-gated Na + channels, stabilizing presynaptic neuronal membranes and inhibiting glutamate release. Lamotrigine can be used for the research of epilepsy, focal seizure, et al.

HY-147377

N-Salicyloyltryptamine	Calcium Channel ERK Potassium Channel Guanylate Cyclase NF-κB	Inflammation/Immunology Neurological Disease
N-Salicyloyltryptamine acts on voltage-dependent Na +, Ca²⁺, and K⁺ ion channels inhibitor. N-Salicyloyltryptamine inhibits K⁺ currents with an IC₅₀ value of 34.6 μM (I_to). N-Salicyloyltryptamine also exhibits anticonvulsant, anti-inflammatory, analgesic, and vasorelaxation effect^-.

HY-A0082

Diphenidol hydrochloride Difenidol hydrochloride	mAChR Sodium Channel	Neurological Disease
Diphenidol hydrochloride (Difenidol hydrochloride) is a non-selective muscarinic M₁-M₄ receptor antagonist, has anti-arrhythmic activity. Diphenidol hydrochloride is also a potent non-specific blocker of voltage-gated ion channels (Na +, K⁺, and Ca²⁺) in neuronal cells.

HY-B1671

(+)-Kavain	GABA Receptor Sodium Channel Calcium Channel	Metabolic Disease Neurological Disease
(+)-Kavain, a main kavalactone extracted from Piper methysticum, has anticonvulsive properties, attenuating vascular smooth muscle contraction through interactions with voltage-dependent Na + and Ca²⁺ channels. (+)-Kavain is shown to bind at the α4β2δ GABA_A receptor and potentiate GABA efficacy. (+)-Kavain is used as a treatment for inflammatory diseases, its anti-inflammatory action has been widely studied.

HY-B0448S1

Phenytoin-15n2,13c	Sodium Channel Virus Protease
Phenytoin-¹⁵N₂,¹³C is the ¹³C and ¹⁵N labeled Phenytoin[1]. Phenytoin (5,5-Diphenylhydantoin) is a potent Voltage-gated Na+ channels (VGSCs) blocker. Phenytoin has antiepileptic activity and reduces breast tumour growth and metastasis in mice[2][3].

HY-120026

KB130015 KB015	Thyroid Hormone Receptor	Neurological Disease
KB130015 (KB015) is an orally active and potent ThRα and ThRβ (Thyroid Hormone Receptor) inhibitor, with IC₅₀ values of 4.5 and 5.1 μM, respectively. KB130015 has antiarrhythmic properties. KB130015 markedly slows the kinetics of inactivation of Na + channels. KB130015 opens large-conductance Ca²⁺-activated K⁺ channels and relaxes vascular smooth muscle.

HY-A0236A

Aprindine hydrochloride	Potassium Channel	Cardiovascular Disease
Aprindine hydrochloride is a class I-b anti-arrhythmic agent and a?hERG channel blocker with an IC₅₀ of 0.23 μM. Aprindine hydrochloride has inhibitory effects on Na +/Ca²⁺ exchanger currents, which is partly responsible for their antiarrhythmic and cardioprotective effects. Aprindine hydrochloride is widely used for trial and ventricular tachyarrhythmias research research.

HY-B0495S4

Lamotrigine-13C3 LTG-¹³C₃; BW430C-¹³C₃	Sodium Channel Autophagy	Neurological Disease
Lamotrigine-¹³C₃ is the ¹³C-labeled Lamotrigine. Lamotrigine (BW430C) is a potent and orally active anticonvulsant or antiepileptic agent. Lamotrigine selectively blocks voltage-gated Na+ channels, stabilizing presynaptic neuronal membranes and inhibiting glutamate release. Lamotrigine can be used for the research of epilepsy, focal seizure, et al[1][2].

HY-101840

EIPA L593754; MH 12-43; Ethylisopropylamiloride	TRP Channel Prostaglandin Receptor Autophagy COX Na+/H+ Exchanger (NHE)	Cancer Inflammation/Immunology
EIPA (L593754) is an orally active TRPP3 channel inhibitor with an IC₅₀ of 10.5 μM. EIPA also enhances autophagy by inhibiting Na +/H⁺-exchanger 3 (NHE3). EIPA inhibits macropinocytosis as well. EIPA can be used in the research of inflammation and cancers, such as gastric cancer, colon carcinoma, pancreatic carcinoma.

HY-101840A

EIPA hydrochloride L593754 hydrochloride; MH 12-43 hydrochloride; Ethylisopropylamiloride hydrochloride	TRP Channel Autophagy COX Prostaglandin Receptor Na+/H+ Exchanger (NHE)	Cancer Inflammation/Immunology
EIPA (L593754) hydrochloride is an orally active TRPP3 channel inhibitor with an IC₅₀ of 10.5 μM. EIPA hydrochloride also enhances autophagy by inhibiting Na +/H⁺-exchanger 3 (NHE3). EIPA hydrochloride inhibits macropinocytosis as well. EIPA hydrochloride can be used in the research of inflammation and cancers, such as gastric cancer, colon carcinoma, pancreatic carcinoma.

HY-B0495S5

Lamotrigine-d3 LTG-d₃; BW430C-d₃	Autophagy Sodium Channel
Lamotrigine-d₃ is the deuterium labeled Lamotrigine[1]. Lamotrigine (BW430C) is a potent and orally active anticonvulsant or antiepileptic agent. Lamotrigine selectively blocks voltage-gated Na+ channels, stabilizing presynaptic neuronal membranes and inhibiting glutamate release. Lamotrigine can be used for the research of epilepsy,?focal seizure, et al[2][3].

HY-B1546

Benzamil Benzylamiloride	Na+/Ca2+ Exchanger Sodium Channel	Neurological Disease
Benzamil (Benzylamiloride), an Amiloride analogue, is a Na +/Ca²⁺ exchanger (NCX) inhibitor (IC₅₀~100 nM). Benzamil also is a non-selective *Deg/epithelial sodium channels* (ENaC)** blocker, and can potentiate myogenic vasoconstriction. Benzamil inhibits TRPP3-mediated Ca²⁺-activated currents, with an IC₅₀ of 1.1 μM.

HY-B1546A

Benzamil hydrochloride Benzylamiloride hydrochloride	Na+/Ca2+ Exchanger Sodium Channel	Neurological Disease
Benzamil hydrochloride (Benzylamiloride hydrochloride), an Amiloride analogue, is a Na +/Ca²⁺ exchanger (NCX) inhibitor (IC₅₀~100 nM). Benzamil hydrochloride also is a non-selective *Deg/epithelial sodium channels* (ENaC)** blocker, and can potentiate myogenic vasoconstriction. Benzamil hydrochloride inhibits TRPP3-mediated Ca²⁺-activated currents, with an IC₅₀ of 1.1 μM.

HY-B0495S1

Lamotrigine-13C,d3 LTG-¹³C,d₃; BW430C-¹³C,d₃	Sodium Channel Autophagy	Neurological Disease
Lamotrigine-¹³C,d₃ is the ¹³C- and deuterium labeled Lamotrigine. Lamotrigine (BW430C) is a potent and orally active anticonvulsant or antiepileptic agent. Lamotrigine selectively blocks voltage-gated Na+ channels, stabilizing presynaptic neuronal membranes and inhibiting glutamate release. Lamotrigine can be used for the research of epilepsy, focal seizure, et al[1][2].

HY-13295

Vinpocetine Ethyl apovincamiNate	Sodium Channel IKK Phosphodiesterase (PDE)	Inflammation/Immunology Neurological Disease Cardiovascular Disease Cancer
Vinpocetine (Ethyl apovincaminate) is a derivative of the alkaloid Vincamine that blocks voltage-gated Na + channels. The IC₅₀ value of Vinpocetine on direct IKK inhibition in the cell-free system is 17.17 μM. Vinpocetine is a phosphodiesterase (PDE) inhibitor and inhibits NF-κB-dependent inflammatory responses by directly targeting IκB kinase complex (IKK), and has been widely used for the treatment of cerebrovascular disorders.

HY-107370

Atomoxetine Tomoxetine; (R)-Tomoxetine	Serotonin Transporter Sodium Channel	Neurological Disease
Atomoxetine (Tomoxetine) is a selective noradrenaline reuptake inhibitor with K_i values of 5, 77 and 1451 nM for norepinephrine (NE), serotonin (5-HT) and dopamine (DA) transporters, respectively. Atomoxetine (Tomoxetine) increases of DA_EX and NE_EX in the PFC and enhances catecholaminergic neurotransmission. Atomoxetine (Tomoxetine) is a potent Na + channels (VGSCs) blocker. Atomoxetine (Tomoxetine) can be used for attention-deficit hyperactivity disorder (ADHD) research.

HY-B0495S3

Lamotrigine-13C2,15N	Autophagy Sodium Channel
Lamotrigine-¹³C₂,¹⁵N is the ¹³C and ¹⁵N labeled Lamotrigine[1]. Lamotrigine (BW430C) is a potent and orally active anticonvulsant or antiepileptic agent. Lamotrigine selectively blocks voltage-gated Na+ channels, stabilizing presynaptic neuronal membranes and inhibiting glutamate release. Lamotrigine can be used for the research of epilepsy,?focal seizure, et al[2][3].

HY-B0495S

Lamotrigine-13C3,d3 LTG-¹³C₃,d₃; BW430C-¹³C₃,d₃	Sodium Channel Autophagy	Neurological Disease
Lamotrigine-¹³C₃,d₃ is the ¹³C-labeled Lamotrigine. Lamotrigine (BW430C) is a potent and orally active anticonvulsant or antiepileptic agent. Lamotrigine selectively blocks voltage-gated Na+ channels, stabilizing presynaptic neuronal membranes and inhibiting glutamate release. Lamotrigine can be used for the research of epilepsy, focal seizure, et al[1][2].

HY-N0603

20(S)-Ginsenoside Rg3 20(S)-PropaNaxadiol; S-ginsenoside Rg3	Sodium Channel Potassium Channel NF-κB COX Amyloid-β Endogenous Metabolite	Cancer Inflammation/Immunology Neurological Disease
20(S)-Ginsenoside Rg3 is the main component of Panax ginseng C. A. Meyer. Ginsenoside Rg3 inhibits Na + and hKv1.4 channel with IC₅₀s of 32.2±4.5 and 32.6±2.2 μM, respectively. 20(S)-Ginsenoside Rg3 also inhibits Aβ levels, NF-κB activity, and COX-2 expression.

HY-13295S

Vinpocetine-d5	Sodium Channel IKK Phosphodiesterase (PDE)	Inflammation/Immunology Neurological Disease Cardiovascular Disease Cancer
Vinpocetine-d₅ is the deuterium labeled Vinpocetine. Vinpocetine (Ethyl apovincaminate) is a derivative of the alkaloid Vincamine that blocks voltage-gated Na+ channels. The IC50 value of Vinpocetine on direct IKK inhibition in the cell-free system is 17.17 μM. Vinpocetine is a phosphodiesterase (PDE) inhibitor and inhibits NF-κB-dependent inflammatory responses by directly targeting IκB kinase complex (IKK), and has been widely used for the treatment of cerebrovascular disorders[1][2][3].

HY-131615

TPC2-A1-P	Sodium Channel	Others
TPC2-A1-P is a powerful and membrane permeable agonist of two pore channel 2 (TPC2) with an EC₅₀ of 10.5 μM. TPC2-A1-P plays its role by mimicking the physiological actions of PI(3,5)P2. TPC2-A1-P also shows higher potency to induce Na 2+ mobilisation from TPC2 than TPC-A1-N (HY-131614). TPC2-A1-P can be used to probe different functions of TPC2 channels in intact cells.

HY-B1033

Metergoline	5-HT Receptor Dopamine Receptor Sodium Channel	Neurological Disease
Metergoline is a serotonin (5-HT) receptor and dopamine receptors antagonist, with pK_is of 8.64, 8.75 and 8.75 for 5-HT_2A, 5-HT_2B and 5-HT_2C, respectively. Metergoline is a high-affinity ligand for the h5-HT₇ receptor, with a K_i of 16 nM. Metergoline is also a reversible neural Na + channels inhibitor. Metergoline is commonly used for the research of seasonal affective disorder, prolactin hormone regulation.

HY-128067

5-(N,N-Hexamethylene)-amiloride Hexamethylene amiloride; HMA	Sodium Channel HIV Apoptosis	Cancer Infection
5-(N,N-Hexamethylene)-amiloride (Hexamethylene amiloride) derives from an amiloride and is a potent Na +/H⁺ exchanger inhibitor, which decreases the intracellular pH (pH_i) and induces apoptosis in leukemic cells. 5-(N,N-Hexamethylene)-amiloride (Hexamethylene amiloride) is also an inhibitor of the HIV-1 Vpu virus ion channel and inhibits mouse hepatitis virus (MHV) replication and human coronavirus 229E (HCoV229E) replication in cultured L929 cells with EC₅₀s of 3.91 μM and 1.34 μM, respectively.

Cat. No.	Product Name

HY-L118

Sodium Channel Blocker Library

115 compounds

Sodium channels conduct sodium ions (Na+) through a cell's plasma membrane that are the source of excitatory currents for the nervous system and muscle. Na channels are classified according to the trigger that opens the channel for such ions, i.e. either a voltage-change (Voltage-gated, voltage-sensitive, or voltage-dependent sodium channel also called VGSCs or Nav channel) or a binding of a substance (a ligand) to the channel (ligand-gated sodium channels). Dysfunction in voltage-gated sodium channels correlates with neurological and cardiac diseases, including epilepsy, myopathies, pain and cardiac arrhythmias. Sodium channel blockers are used in the treatment of cardiac arrhythmia, pain and convulsion.

MCE offers a unique collection of 115 sodium channel blocker and antagonists, all of which have the identified inhibitory effect on sodium channels. MCE Sodium Channel Blocker Library can be used for neurological and cardiac diseases drug discovery and sodium channel research.

Cat. No.	Product Name	Type