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Results for "

Natural Inhibitors

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (4) Acyltransferase (1) ADC Cytotoxin (2) ADC Linker (1) Adenosine Receptor (1) Akt (14) Aldehyde Dehydrogenase (ALDH) (1) Aminopeptidase (7) AMPK (5) Amyloid-β (6) Androgen Receptor (2) Angiotensin-converting Enzyme (ACE) (3) Antibiotic (22) AP-1 (1) Apoptosis (99) ATM/ATR (2) ATP Synthase (1) Autophagy (52) Bacterial (44) Bcl-2 Family (3) Beta-lactamase (1) Beta-secretase (1) Biochemical Assay Reagents (5) c-Myc (1) C-type Lectin-like Receptors (CTLRs) (2) Calcium Channel (3) Carboxylesterase (CES) (3) Casein Kinase (3) Caspase (13) CD276/B7-H3 (1) CDK (4) Checkpoint Kinase (Chk) (1) Cholinesterase (ChE) (8) ClpP (2) CMV (3) COX (22) CRM1 (1) CXCR (1) Cytochrome P450 (9) DAGL (1) Dihydroorotate Dehydrogenase (2) Dipeptidyl Peptidase (1) DNA/RNA Synthesis (8) Drug Intermediate (1) Drug Metabolite (1) DYRK (3) E1/E2/E3 Enzyme (4) EBV (2) EGFR (7) Elastase (1) Endogenous Metabolite (49) Enolase (1) Enterovirus (1) Epigenetic Reader Domain (5) Epoxide Hydrolase (1) ERK (2) Estrogen Receptor/ERR (1) FAAH (1) Farnesyl Transferase (1) Fatty Acid Synthase (FASN) (2) Ferroptosis (9) Fungal (15) GABA Receptor (1) GLUT (1) Glutathione S-transferase (3) Glycosidase (14) HBV (5) HDAC (4) Hedgehog (5) Herbicide (1) HIF/HIF Prolyl-Hydroxylase (3) Histamine Receptor (3) Histone Acetyltransferase (7) Histone Demethylase (1) HIV (12) HIV Protease (2) HMG-CoA Reductase (HMGCR) (1) HSP (2) HSV (4) ICMT (1) IFNAR (3) IKK (5) Influenza Virus (13) Interleukin Related (12) Isotope-Labeled Compounds (23) JAK (5) JNK (4) Keap1-Nrf2 (9) Leukotriene Receptor (1) Lipase (2) Lipoxygenase (2) MAGL (1) MAP3K (1) MAPKAPK2 (MK2) (2) MARCKS (1) MDM-2/p53 (1) Microtubule/Tubulin (1) Mitochondrial Metabolism (6) Mitophagy (17) Mitosis (2) MMP (3) Monoamine Oxidase (2) mTOR (4) Necroptosis (1) NF-κB (23) NO Synthase (9) NOD-like Receptor (NLR) (3) Nuclear Factor of activated T Cells (NFAT) (1) Organoid (1) Ornithine decarboxylase (ODC) (1) P-glycoprotein (1) P-selectin (1) P2X Receptor (1) p38 MAPK (13) Parasite (31) PARP (1) PCSK9 (2) PDGFR (1) PERK (1) Phosphatase (9) Phosphodiesterase (PDE) (1) Phospholipase (1) Phytohormone (1) PI3K (19) Pim (2) PKC (5) Platelet-activating Factor Receptor (PAFR) (1) Polo-like Kinase (PLK) (1) Potassium Channel (1) PPAR (11) Proteasome (6) Proton Pump (5) RABV (1) RAR/RXR (7) Reactive Oxygen Species (29) Reference Standards (4) Reverse Transcriptase (1) Ribosomal S6 Kinase (RSK) (1) RIP kinase (1) ROS Kinase (2) SARS-CoV (3) SGLT (2) SHP2 (2) Sirtuin (5) Smo (2) Src (3) STAT (14) Survivin (1) TGF-beta/Smad (4) TNF Receptor (8) Toll-like Receptor (TLR) (9) Topoisomerase (8) Tyrosinase (8) UGT (1) VEGFR (6) Virus Protease (2) Wnt (2) Xanthine Oxidase (2) β-catenin (2) γ-Glutamyl Transferase (GGT) (2)
By Research Areas:	Cancer (258) Cardiovascular Disease (30) Endocrinology (7) Infection (105) Inflammation/Immunology (137) Metabolic Disease (60) Neurological Disease (49)
Click Chemistry:	Azide (1) Alkynes (2)
Oligonucleotides:	Antioxidants (1) Preservatives (1) Chelating Agents (1)

424

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

320

Natural
Products

Isotope-Labeled Compounds

Click Chemistry

Oligonucleotides

Targets Recommended: Serpin

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N0149

Salicin 1 Publications Verification D-(−)-Salicin; Salicoside	COX Endogenous Metabolite	Inflammation/Immunology Cancer
Salicin is a natural COX inhibitor.

HY-N3748

Dihydromorin	Tyrosinase	Cancer
Dihydromorin, a natural flavanonol compound, is a tyrosinase inhibitor .

HY-113008B

trans-Urocanic acid (E)-Urocanic acid; trans-UCA	Endogenous Metabolite	Inflammation/Immunology
trans-urocanic acid (trans-UCA), a natural epidermal constituent, inhibits human natural killer cell (NK) activity in vitro. trans-urocanic acid is active in regulating an immune function .

HY-N12133

4,7-Didehydroneophysalin B	Others	Metabolic Disease
4,7-Didehydroneophysalin B is a flavonoid with cholinesterase inhibiting activity. 4,7-Didehydroneophysalin B can be isolated and purified from the natural Physalis alkekengi L. var. franchetii (Mast.) Makino.

HY-N11711

Pumiloside	Cholinesterase (ChE)	Others
Pumiloside is a natural product that can be isolated from Nauclea officinalis. Pumiloside is a AchE inhibitor with IC₅₀ value of 118.36 μM .

HY-164041

Staurosporine-Boc	PKC	Others
Staurosporine-Boc, a natural product isolated from the actinomyces Streptomyces staurosporeus, is a potent non-selective inhibitor of protein kinase. Staurosporine-Boc inhibits a variety of protein kinases, including protein kinase C (PKC), tyrosine kinase, and serine/threonine kinase. Because of its broad inhibition profile, Staurosporine-Boc is widely used as a tool compound in biological research, especially when studying cell signaling pathways .

HY-118747

Scirpusin A	HIV	Infection
Scirpusin A is a naturally occurring compound extracted from the legume plant Caragana rosea Turcz, exhibiting anti-HIV activity. Scirpusin A demonstrates significant inhibitory effects against HIV-1 (EC₅₀=7 μg/mL). Scirpusin A is utilized in research towards the development of anti-HIV therapeutics .

HY-N3091

Persiconin	Tyrosinase	Others
Persiconin is a tyrosinase Inhibitor. Persiconin can be isolated from Prunus persica. Persiconin has tyrosinase inhibitory activity of 46% at 500 μM. Persiconin can be used in whitening research .

HY-N7291

Tryprostatin A	Others	Others
Tryprostatin A is an inhibitor of the mammalian cell cycle. Tryprostatins A can be isolated from the secondary metabolites of a marine fungal strain BM939 .

HY-N12846

Neokadsuranic acid A	Others	Metabolic Disease
Neokadsuranic acid A is a cholesterol biosynthesis inhibitor that reduces the activity of cholesterol. Neokadsuranic acid A is a triterpenoid compound that can be isolated from Kadsura heteroclita, a plant of the Schisandraceae family. Neokadsuranic acid A can be used to study the cholesterol biosynthesis pathway and its role in traditional medicine .

HY-N3861

Erythrocentaurin	HBV	Infection
Erythrocentaurin, a natural compound, is a new class of hepatitis B virus inhibitor .

HY-N8921

Methoxyanigorufone 2-O-Methylanigorufone	Fungal	Infection
Methoxyanigorufone (compound 4) is a compound that can be isloated from Musa acuminata var. "Yangambi km 5" .

HY-N4168A

Neochlorogenic acid methyl ester 5-O-Caffeoylquinic acid methyl ester	HBV	Infection Cancer
Neochlorogenic acid methyl ester (5-O-Caffeoylquinic acid methyl ester) is an HBV inhibitor. Neochlorogenic acid methyl ester can be isolated from L. japonica flower buds with potent HBV inhibitory activity .

HY-N0716

Berberine Natural Yellow 18	Antibiotic Topoisomerase Autophagy Bacterial Reactive Oxygen Species Parasite Apoptosis PI3K Akt Caspase JNK AP-1 NF-κB	Infection Cardiovascular Disease Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Berberine (Natural Yellow 18) is an alkaloid isolated from the Chinese herbal medicine Huanglian, as an antibiotic. Berberine (Natural Yellow 18) induces reactive oxygen species (ROS) generation and inhibits DNA topoisomerase. Berberine (Natural Yellow 18) has antineoplastic properties. The sulfate form (HY-N0716B) improves bioavailability .

HY-N0243

Theaflavin 3 Publications Verification	Influenza Virus Endogenous Metabolite	Infection
Theaflavin is a suitable natural inhibitor against influenza A (H1N1) neuraminidase.

HY-N8151

Sanguisorbigenin	Bacterial	Infection
Sanguisorbigenin is a natural antibacterial agent that inhibits methicillin-resistant S. aureus (MRSA) .

HY-N0077

Ginkgolic Acid 5+ Cited Publications Ginkgolic acid (15:1); Ginkgolic acid I; Romanicardic acid	E1/E2/E3 Enzyme	Cancer
Ginkgolic Acid is a natural compound that inhibits SUMOylation with an IC₅₀ of 3.0 μM in in vitro assay.

HY-121038

Chamazulene	Leukotriene Receptor	Inflammation/Immunology
Chamazulene, a natural compound, is an antioxidant-type inhibitor of leukotriene B4 formation .

HY-N13932

Arabenoic acid	Herbicide	Others
Arabenoic acid is a natural product herbicide of fungal origin. Arabenoic acid inhibits the growth of Arabidopsis thaliana .

HY-N8724

Lamalbid	ROS Kinase	Others
Lamalbid is a natural product that can be found in Lantana montevidensis. Lamalbid inhibits ROS generation .

HY-N1523

Rengyol Cleroindicin A	Others	Neurological Disease
Rengyol (Cleroindicin A), a natural alcohol compound, is an inhibitor of emesis induced by copper sulfate pentahydrate .

HY-N2715

6-Methoxynaringenin	NO Synthase	Inflammation/Immunology
6-Methoxynaringenin is a natural flavonoid that inhibits NO production with an IC₅₀ of 25.8 μM .

HY-N2522

Carboxyatractyloside dipotassium 2 Publications Verification Gummiferin dipotassium	Others	Others
Carboxyatractyloside dipotassium is a toxic natural product, acts as an inhibitor of ADP/ATP carrier, inhibits mitochondrial ADP/ATP transport .

HY-114519

Helenalin acetate 1 Publications Verification	Histone Demethylase NF-κB	Inflammation/Immunology Cancer
Helenalin acetate, a natural NF-κB inhibitor, is a potent C/EBPβ inhibitor. Helenalin acetate has anti-inflammatory and anticancer activities .

HY-N8399

Yadanziolide B	Influenza Virus	Infection Inflammation/Immunology
Yadanziolide B, a natural quassinoid, is a potential H5N1 neuraminidase inhibitor .

HY-121291

Aureothin	HIV	Infection
Aureothin, is a natural polyketide, is a HIV inhibitor with an IC₅₀ of 5.3 nM. Aureothin is a microbial biolarvicide .

HY-N2033

Chebulinic acid 2 Publications Verification	DNA/RNA Synthesis TGF-beta/Smad Proton Pump	Infection
Chebulinic acid is a potent natural inhibitor of M. tuberculosis DNA gyrase, also can inhibit SMAD-3 phosphorylation, inhibit H+ K+-ATPase activity.

HY-P6294

Pseudostellarin G	Tyrosinase	Others
Pseudostellarin G is a natural cyclic octapeptide. Pseudostellarin G has the activity of inhibiting tyrosinase. Pseudostellarin G can inhibit the production of melanin .

HY-N0859

Schisanhenol Schizanhenol; Gomisin-K3	UGT	Cancer
Schisanhenol is a natural compound solated from Schisandra rubriflora; UGT2B7 UDP-glucuronosyltransferases inhibitor.

HY-B0183A

Ellagic acid (hydrate)	Casein Kinase	Cancer
Ellagic acid hydrate is a natural antioxidant, and acts as a potent and ATP-competitive CK2 inhibitor, with an IC₅₀ of 40 nM and a K_i of 20 nM .

HY-N0149R

Salicin (Standard)	COX Endogenous Metabolite	Inflammation/Immunology Cancer
Salicin (Standard) is the analytical standard of Salicin. This product is intended for research and analytical applications. Salicin is a natural COX inhibitor.

HY-121482

(+)-Ochromycinone STA-21	STAT	Inflammation/Immunology Cancer
(+)-Ochromycinone is a natural antibiotic that potently inhibits STAT3. (+)-Ochromycinone is used in the researches of cancers and psoriasis .

HY-B0183

Ellagic acid 15+ Cited Publications	Casein Kinase Reactive Oxygen Species Endogenous Metabolite SHP2	Neurological Disease Cancer
Ellagic acid is a natural antioxidant, and acts as a potent and ATP-competitive inhibitor of CK2 and SHP2, with an IC₅₀ of 40 nM and a K_i of 20 nM.

HY-N0168

Hesperetin 10+ Cited Publications	p38 MAPK Autophagy Apoptosis	Neurological Disease Cancer
Hesperetin is a natural flavanone, and acts as a potent and broad-spectrum inhibitor against human UGT activity. Hesperetin regulates apoptosis.

HY-W004291

Methyl arachidate Methyl icosanoate	Aminopeptidase	Inflammation/Immunology
Methyl arachidate (Methyl eicosanoate), a natural compound, is a leukotriene A4 hydrolase (LTA4H) inhibitor .

HY-N3180

Norbraylin	Phosphodiesterase (PDE)	Inflammation/Immunology
Norbraylin, a natural prenylated coumarin, is a PDE4D2 inhibitor with an IC₅₀ value of 7.15 μM .

HY-N2392

Kukoamine A 1 Publications Verification	Parasite	Infection Cardiovascular Disease
Kukoamine A is a natural occurring spermine derivative, acts as a potent inhibitor of trypanothione reductase (K_i, 1.8 μM), with antihypertensive activity .

HY-N3710

Dehydrocrenatidine Kumujian G; O-Methylpicrasidine I	JAK Apoptosis	Neurological Disease Cancer
Dehydrocrenatidine, a natural alkaloid, is a specific JAK inhibitor. Dehydrocrenatidine inhibits voltage-gated sodium channels and ameliorates mechanic allodia in a rat model of neuropathic pain .

HY-13930

Miquelianin 3 Publications Verification Quercetin 3-O-glucuronide; Quercetin 3-glucuronide	Endogenous Metabolite	Cancer
Miquelianin (Quercetin 3-O-glucuronide) is a metabolite of quercetin and a type of natural flavonoid. Miquelianin is also a CBR1 inhibitor.

HY-N1950

Hispidulin 2 Publications Verification Dinatin	Pim	Cancer
Hispidulin is a natural flavone with a broad spectrum of biological activities. Hispidulin is a Pim-1 inhibitor with an IC₅₀ of 2.71 μM.

HY-N0125

Diosmetin 5+ Cited Publications	Cytochrome P450	Cancer
Diosmetin is a natural flavonoid which inhibits human CYP1A enzyme activity with an IC₅₀ of 40 μM in HepG2 cell.

HY-N8530

Conodurine	Others	Inflammation/Immunology
Conodurine is a monoterpenoid indole alkaloid. Conodurine can inhibit lysosomal acidification. Conodurineis isolated from the natural Tabernaemontana corymbosa .

HY-N1405

Cucurbitacin I 10+ Cited Publications Elatericin B; JSI-124; NSC-521777	STAT JAK	Cancer
Cucurbitacin I is a natural selective inhibitor of JAK2/STAT3, with potent anti-cancer activity.

HY-N3789

Dunnianol	Bacterial	Infection
Dunnianol is a natural sesqui-neoligan with moderate antibacterial activity. Dunnianol inhibits *Staphylococcus aureus* and *methicillin-resistant Staphylococcus aureus* (MRSA)**.

HY-131504A

Valienamine	Glycosidase	Metabolic Disease
Valienamine is the alpha-glucosidase inhibitor. Valienamine is the key functional component of many natural glycosidase inhibitors including the crop protectant validamycin A and the antidiabetic agent acarbose .

HY-P3356

Cyclotheonellazole A	Elastase Proteasome	Inflammation/Immunology
Cyclotheonellazole A is a natural macrocyclic peptide and a potent elastase inhibitor (IC₅₀=0.034 nM). Cyclotheonellazole A inhibits chymotrypsin with an IC₅₀ value of 0.62 nM .

HY-N9084

9-Hydroxyeriobofuran	Others	Others
9-Hydroxyeriobofuran is a natural product that can be found in Pyracantha koidzumii. 9-Hydroxyeriobofuran inhibits HEMn cell growth .

HY-128000

ML095 CID-25067483	Phosphatase	Others
ML095 is a biochemical inhibitor of PLAP. ML095 is useful to elucidate the key biological functions and natural substrates of human PLAP .

HY-N2087

Ligupurpuroside A	Lipase	Metabolic Disease
Ligupurpuroside A is an active product that can be extracted from Ligustrum robustum. Ligupurpuroside A acts as a natural inhibitor of lipase in a competitive manner .

HY-N2697

6-Acetonyl-N-methyldihydrodecarine	Monoamine Oxidase	Neurological Disease
6-Acetonyl-N-methyldihydrodecarine is a natural alkaloid that can be isolated from roots of Zanthoxylum rigidum. An inhibitor of monoamine oxidases .

Cat. No.	Product Name

HY-L001V

MCE Bioactive Compound Library	26,953 compounds
A unique collection of 26,953 bioactive compounds including natural products, enzyme inhibitors, receptor ligands, and drugs for high throughput screening (HTS) and high content screening (HCS).

HY-L001

Bioactive Compound Library

22,302 compounds

Bioactive compounds are a general term for a class of substances that can cause certain biological effects in the body, which are the main source of small molecule drugs. These compounds generally penetrate cell membranes, act on specific target proteins in cells, regulate intracellular signaling pathways, and cause some changes in cell phenotype.

MCE owns a unique collection of 22,302 compounds with confirmed biological activities and clear targets. These compounds include natural products, innovative compounds, approved compounds, and clinical compounds. These can also be used for signal pathway research, drug discovery and drug repurposing, etc.

HY-L084

Microbial Metabolite Library

1,149 compounds

Nature has been a source of medicinal products for millennia, with many useful active substances developed from plant sources. In the 20th century, the discovery of the penicillin was the starting point for drug discovery from microbial sources. Microorganisms， which have been considered to be a rich source of unique bioactive compounds, play an important role in the development of the chemistry of natural products and medical therapy. Microbial metabolites have proved to be affective antimicrobial agents, anti-tumor agents, enzyme inhibitors, anti-inflammatory agents, etc. Today, many microbial-originated antibiotics are available in the mark, and a large number of bioactive metabolites are used in medicine.

MCE provides a unique collection of 1,149 microbial metabolites, which is an important source of lead compounds and can be used for drug discovery.

Cat. No.	Product Name	Type

HY-N0116

Hematoxylin 5+ Cited Publications Natural Black 1; Haematoxylin	Chromogenic Substrates
Hematoxylin (Natural Black 1), a naturally occurring flavonoid compound derived from Caesalpinia sappan Linn.. Hematoxylin is a nuclear stain in histology and is also a potent Aβ42 fibrillogenesis inhibitor with an IC₅₀ of 1.6 μM.

HY-16561G

Resveratrol (GMP)

trans-Resveratrol (GMP); SRT501 (GMP)

Fluorescent Dye

Resveratrol (trans-Resveratrol; SRT501), a natural polyphenolic phytoalexin that possesses anti-oxidant, anti-inflammatory, cardioprotective, and anti-cancer properties. Resveratrol (SRT 501) has a wide spectrum of targets including mTOR, JAK, β-amyloid, Adenylyl cyclase, IKKβ, DNA polymerase. Resveratrol also is a specific SIRT1 activator . Resveratrol is a potent pregnane X receptor (PXR) inhibitor . Resveratrol is an Nrf2 activator, ameliorates aging-related progressive renal injury in mice model . Resveratrol increases production of NO in endothelial cells .

Cat. No.	Product Name	Type

HY-W035903

Ethanolamine hydrochloride

2-Aminoethanol hydrochloride

Buffer Reagents

Ethanolamine hydrochloride, is an organic compound used in various industrial applications. It is a white or colorless solid that is soluble in water and has a faint odor. One of the major uses of Ethanolamine hydrochloride is in the production of detergents and surfactants. Used as a raw material in the manufacture of compounds such as ethylenediaminetetraacetic acid (EDTA) and diethanolamine, which are commonly used in household and industrial cleaning products. Ethanolamine hydrochloride is also used in the synthesis of pharmaceuticals, agrochemicals and rubber processing agents. It acts as a buffer in certain chemical reactions, helping to adjust pH and maintain stability. Ethanolamine hydrochloride can be used for gas purification and metal corrosion inhibitor. Its ability to react with acid gases such as carbon dioxide and sulfur dioxide makes it useful for removing impurities from natural gas and other industrial gases. Overall, Ethanolamine hydrochloride is a multifunctional compound with many potential industrial applications. Its ability to act as a buffer, chelating agent, and corrosion inhibitor makes it an important tool in a variety of industries.

HY-16561G

Resveratrol (GMP)

trans-Resveratrol (GMP); SRT501 (GMP)

Biochemical Assay Reagents

Cat. No.	Product Name	Target	Research Area

HY-129283B

Goralatide acetate	Peptides	Metabolic Disease
Goralatide, a natural tetrapeptide, is a physiological regulator of hematopoiesis. Goralatide can inhibit primitive haematopoietic cell proliferation .

HY-P0266B

N-Acetyl-Ser-Asp-Lys-Pro acetate Ac-SDKP acetate	Angiotensin-converting Enzyme (ACE)	Inflammation/Immunology
N-Acetyl-Ser-Asp-Lys-Pro (Ac-SDKP) acetate is a specific substrate for the N-terminal active site of angiotensin-converting enzyme (ACE). N-Acetyl-Ser-Asp-Lys-Pro acetate is a natural inhibitor of pluripotent hematopoietic stem cell proliferation. Anti-inflammatory and antifibrotic properties .

HY-P1259A

PR-39 TFA	Proteasome Bacterial	Inflammation/Immunology
PR-39 TFA, a natural proline- and arginine-rich antibacterial peptide, is a noncompetitive, reversible and allosteric proteasome inhibitor. PR-39 TFAreversibly binds to the α7 subunit of the proteasome and blocks degradation of NF-κB inhibitor IκBα by the ubiquitin-proteasome pathway. PR-39 TFA stimulates angiogenesis, inhibits inflammatory responses and significant reduces myocardial infarct size in mice .

HY-W013494

L-Carnosine 2 Publications Verification	Endogenous Metabolite	Metabolic Disease Inflammation/Immunology
L-Carnosine is a dipeptide composed of beta-alanine and histidine. L-Carnosine is an endogenous metabolite found in human brain, muscle and gastrointestinal tissues and is present in all vertebrates. L-Carnosine is a non-enzymatic free radical scavenger and natural antioxidant with anti-inflammatory and neuroprotective properties that can inhibit biochemical changes associated with aging .

HY-P6294

Pseudostellarin G	Tyrosinase	Others
Pseudostellarin G is a natural cyclic octapeptide. Pseudostellarin G has the activity of inhibiting tyrosinase. Pseudostellarin G can inhibit the production of melanin .

HY-P2783

Destruxin B2	HBV	Infection
Destruxin B2 (compound 5) is a natural depsipeptide that can be inhibits hepatitis B surface antigen (HBsAg) secretion in Hep3B cells with an IC₅₀ 1.30 μM .

HY-P1259

PR-39	Proteasome Bacterial	Inflammation/Immunology
PR-39, a natural proline- and arginine-rich antibacterial peptide, is a noncompetitive, reversible and allosteric proteasome inhibitor. PR-39 reversibly binds to the α7 subunit of the proteasome and blocks degradation of NF-κB inhibitor IκBα by the ubiquitin-proteasome pathway. PR-39 stimulates angiogenesis, inhibits inflammatory responses and significant reduces myocardial infarct size in mice .

HY-P10817

Corza6	Proton Pump Reactive Oxygen Species	Metabolic Disease
Corza6 is a potent and selective human voltage-gated proton channel (hHv1) peptide inhibitor. Corza6 binds to the external voltage sensor domain (VSD) loop in hHv1 with a K_d of ~1 nM at the natural, hyperpolarized resting membrane potential (RMP) of mammalian cells. Corza6 allows capacitation in sperm and permits sustained reactive oxygen species (ROS) production in white blood cells (WBCs) .

HY-P10429

RCP168	CXCR	Infection
RCP168 is a highly selective and affinity CXCR4 receptor antagonist (IC₅₀=5 nM). RCP168 has a stronger ability than natural chemical factors to inhibit the entry of HIV-1 (human immunodeficiency virus type 1) into host cells via CXCR4 receptors. RCP168 inhibits HIV-1 infection by blocking viral binding sites or inducing receptor internalization. RCP168 can be used to analyze the interaction between CXCR4 receptor and other chemical factor receptors .

HY-P5439

Epsilon-V1-2, Cys-conjugated	PKC MARCKS	Others
Epsilon-V1-2, Cys-conjugated is a biological active peptide. (This peptide is the εPKC specific inhibitor. Its inhibitory activity is based on εPKC translocation and MARCKS phosphorylation. This peptide interferes with εPKC interaction with the anchoring protein εRACK. This peptide contains a cysteine residue added to the C-terminus for potential S-S bond formation with a carrier protein.Pyroglutamyl (pGlu) peptides may spontaneously form when either Glutamine (Q) or Glutamic acid (E) is located at the sequence N-terminus. The conversion of Q or E to pGlu is a natural occurrence and in general it is believed that the hydrophobic γ-lactam ring of pGlu may play a role in peptide stability against gastrointestinal proteases. Pyroglutamyl peptides are therefore considered a normal subset of such peptides and are included as part of the peptide purity during HPLC analysis.)

Cat. No.	Product Name	Target	Research Area

HY-P9977

Amivantamab 1 Publications Verification JNJ-61186372	EGFR	Cancer
Amivantamab (JNJ-61186372) is a human EGFR-MET bispecific antibody with immune anticancer activity. Amivantamab inhibits ligand binding, promotes endocytosis and degradation of receptor-antibody complexes, and induces Fc-dependent cytokinesis in macrophages and antibody-dependent cytotoxicity in natural killer cells .

HY-P99032

Monalizumab 3 Publications Verification IPH2201	Checkpoint Kinase (Chk) IFNAR	Inflammation/Immunology Cancer
Monalizumab (IPH2201) is an immune checkpoint inhibitor targeting Natural Killer Group 2A (NKG2A). Monalizumab, a humanized anti-NKG2A blocking mAb, increases IFN-γ production, thereby promoting NK cell effector functions. Monalizumab can be used for the research of head and neck squamous cell carcinoma (HNSCC) .

HY-P99157

Omburtamab	CD276/B7-H3	Cancer
Omburtamab is a humanized monoclonal antibody targeting B7-H3 (CD276). Omburtamab selectively binds to B7-H3 highly expressed on the surface of tumor cells and activates anti-tumor immune responses mediated by T cells and natural killer (NK) cells. Omburtamab can promote the specific infiltration of CAR-T cells into tumors, enhance the killing function of NK cells through the CD16 signaling pathway, and regulate tumor cell glucose metabolism (such as inhibiting the Warburg effect). Omburtamab has the potential to inhibit solid tumors such as non-small cell lung cancer (NSCLC) .

HY-P99361

Enavatuzumab PDL192; ABT-361; Anti-TNFRSF12A/TWEAKR/CD266 Reference Antibody (enavatuzumab)	TNF Receptor	Cancer
Enavatuzumab (PDL192; ABT-361) is a humanized IgG1 monoclonal antibody targeting the receptor of TNF-like weak inducer of apoptosis (TWEAK). TWEAK (Fn14; TNFRSF12A), the natural ligand of the TWEAK receptor (TweakR), stimulates multiple cellular responses. Enavatuzumab induces tumor growth inhibition through direct TweakR signaling and antibody dependent cell-mediated cytotoxicity (ADCC). Enavatuzumab can actively recruits and activates myeloid effectors to kill tumor cells. Enavatuzumab inhibits the growth of various human TweakR-positive cancer cell lines and xenografts in vitro and in vivo .

HY-P9977A

Amivantamab (FUT8-KO)	EGFR	Cancer
Amivantamab (FUT8-KO) is an anti-EGFR-MET monoclonal antibody expressed by CHO cells with the fucosyltransferase 8 gene (FUT8) knocked out. Fucose deficiency enhances the ADCC effect of the antibody. Amivantamab (FUT8-KO) inhibits ligand binding, promotes endocytosis and degradation of receptor-antibody complexes, and induces Fc-dependent cytokinesis in macrophages and antibody-dependent cytotoxicity in natural killer cells .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0149

Salicin 1 Publications Verification D-(−)-Salicin; Salicoside	Structural Classification Natural Products Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Source classification Plants Endogenous metabolite Inflammation/Immunology Disease Research Fields Salicaceae Salix babylonica Linn.	COX Endogenous Metabolite
Salicin is a natural COX inhibitor.

HY-N3748

Dihydromorin	Flavanonols Flavonoids other families Classification of Application Fields Source classification Phenols Polyphenols Plants Disease Research Fields Cancer	Tyrosinase
Dihydromorin, a natural flavanonol compound, is a tyrosinase inhibitor .

HY-113008B

trans-Urocanic acid (E)-Urocanic acid; trans-UCA	Structural Classification Human Gut Microbiota Metabolites Classification of Application Fields Ketones, Aldehydes, Acids Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields	Endogenous Metabolite
trans-urocanic acid (trans-UCA), a natural epidermal constituent, inhibits human natural killer cell (NK) activity in vitro. trans-urocanic acid is active in regulating an immune function .

HY-N12133

4,7-Didehydroneophysalin B	Structural Classification Natural Products Source classification Solanaceae Plants Alkekengi officinarum Moench	Others
4,7-Didehydroneophysalin B is a flavonoid with cholinesterase inhibiting activity. 4,7-Didehydroneophysalin B can be isolated and purified from the natural Physalis alkekengi L. var. franchetii (Mast.) Makino.

HY-N11711

Pumiloside	Structural Classification Alkaloids Nauclea officinalis (Pirre ex Pitard) Merr. Other Alkaloids Source classification Rubiaceae Plants Indole Alkaloids	Cholinesterase (ChE)
Pumiloside is a natural product that can be isolated from Nauclea officinalis. Pumiloside is a AchE inhibitor with IC₅₀ value of 118.36 μM .

HY-118747

Scirpusin A	Structural Classification Caragana rosea Turcz. ex Maxim. Source classification Phenols Polyphenols Plants Fabaceae	HIV
Scirpusin A is a naturally occurring compound extracted from the legume plant Caragana rosea Turcz, exhibiting anti-HIV activity. Scirpusin A demonstrates significant inhibitory effects against HIV-1 (EC₅₀=7 μg/mL). Scirpusin A is utilized in research towards the development of anti-HIV therapeutics .

HY-N3091

Persiconin	Structural Classification Flavonoids Classification of Application Fields Flavonones Source classification Other Diseases Rosaceae Cosmetic Research Plants Disease Research Fields Amygdalus persica L.	Tyrosinase
Persiconin is a tyrosinase Inhibitor. Persiconin can be isolated from Prunus persica. Persiconin has tyrosinase inhibitory activity of 46% at 500 μM. Persiconin can be used in whitening research .

HY-N7291

Tryprostatin A	Structural Classification Alkaloids Microorganisms Other Alkaloids Source classification	Others
Tryprostatin A is an inhibitor of the mammalian cell cycle. Tryprostatins A can be isolated from the secondary metabolites of a marine fungal strain BM939 .

HY-N12846

Neokadsuranic acid A	Triterpenes Structural Classification Kadsura heteroclita (Roxb.) Craib Terpenoids Source classification Plants Schisandraceae	Others
Neokadsuranic acid A is a cholesterol biosynthesis inhibitor that reduces the activity of cholesterol. Neokadsuranic acid A is a triterpenoid compound that can be isolated from Kadsura heteroclita, a plant of the Schisandraceae family. Neokadsuranic acid A can be used to study the cholesterol biosynthesis pathway and its role in traditional medicine .

HY-N3861

Erythrocentaurin	Structural Classification Natural Products Gentiana macrophylla Pall. Source classification Gentianaceae Plants	HBV
Erythrocentaurin, a natural compound, is a new class of hepatitis B virus inhibitor .

HY-N8921

Methoxyanigorufone 2-O-Methylanigorufone	Quinones Structural Classification Source classification Musaceae Plants Naphthalene Quinones	Fungal
Methoxyanigorufone (compound 4) is a compound that can be isloated from Musa acuminata var. "Yangambi km 5" .

HY-N4168A

Neochlorogenic acid methyl ester 5-O-Caffeoylquinic acid methyl ester	Structural Classification Caprifoliaceae Lonicera japonica Thunb. Source classification Phenols Polyphenols Plants	HBV
Neochlorogenic acid methyl ester (5-O-Caffeoylquinic acid methyl ester) is an HBV inhibitor. Neochlorogenic acid methyl ester can be isolated from L. japonica flower buds with potent HBV inhibitory activity .

HY-N0716

Berberine Natural Yellow 18	Structural Classification Classification of Application Fields Anti-aging Ranunculaceae Source classification Plants Endogenous metabolite Biological Pesticide Research Agricultural Research Alkaloids Coptis chinensis Franch. Isoquinoline Alkaloids Inflammation/Immunology Disease Research Fields Cancer	Antibiotic Topoisomerase Autophagy Bacterial Reactive Oxygen Species Parasite Apoptosis PI3K Akt Caspase JNK AP-1 NF-κB
Berberine (Natural Yellow 18) is an alkaloid isolated from the Chinese herbal medicine Huanglian, as an antibiotic. Berberine (Natural Yellow 18) induces reactive oxygen species (ROS) generation and inhibits DNA topoisomerase. Berberine (Natural Yellow 18) has antineoplastic properties. The sulfate form (HY-N0716B) improves bioavailability .

HY-N0243

Theaflavin 3 Publications Verification	Infection Structural Classification Flavonoids other families Classification of Application Fields Flavanols Source classification Phenols Polyphenols Plants Endogenous metabolite Disease Research Fields	Influenza Virus Endogenous Metabolite
Theaflavin is a suitable natural inhibitor against influenza A (H1N1) neuraminidase.

HY-N8151

Sanguisorbigenin	Infection Triterpenes Structural Classification Classification of Application Fields Sanguisorba officinalis Linn. Terpenoids Source classification Rosaceae Plants Disease Research Fields	Bacterial
Sanguisorbigenin is a natural antibacterial agent that inhibits methicillin-resistant S. aureus (MRSA) .

HY-N0077

Ginkgolic Acid 5+ Cited Publications Ginkgolic acid (15:1); Ginkgolic acid I; Romanicardic acid	Structural Classification Monophenols Ginkgoaceae Classification of Application Fields Ketones, Aldehydes, Acids Source classification Phenols Plants Ginkgo biloba Disease Research Fields Cancer	E1/E2/E3 Enzyme
Ginkgolic Acid is a natural compound that inhibits SUMOylation with an IC₅₀ of 3.0 μM in in vitro assay.

HY-121038

Chamazulene	Natural Products Source classification Distemonanthus benthamianus Baill. Plants Compositae	Leukotriene Receptor
Chamazulene, a natural compound, is an antioxidant-type inhibitor of leukotriene B4 formation .

HY-N13932

Arabenoic acid	Structural Classification Natural Products Microorganisms Source classification	Herbicide
Arabenoic acid is a natural product herbicide of fungal origin. Arabenoic acid inhibits the growth of Arabidopsis thaliana .

HY-N8724

Lamalbid	Structural Classification Verbenaceae Source classification Plants Saccharides Monosaccharides Lantana montevidensis Briq.	ROS Kinase
Lamalbid is a natural product that can be found in Lantana montevidensis. Lamalbid inhibits ROS generation .

HY-N1523

Rengyol Cleroindicin A	Natural Products Classification of Application Fields Neurological Disease Oleaceae Source classification Plants Forsythia suspensa (Thunb.) Vahl Disease Research Fields	Others
Rengyol (Cleroindicin A), a natural alcohol compound, is an inhibitor of emesis induced by copper sulfate pentahydrate .

HY-N2715

6-Methoxynaringenin	Structural Classification Flavonoids Labiatae Flavonones Source classification Derris robusta Plants	NO Synthase
6-Methoxynaringenin is a natural flavonoid that inhibits NO production with an IC₅₀ of 25.8 μM .

HY-N2522

Carboxyatractyloside dipotassium 2 Publications Verification Gummiferin dipotassium	Structural Classification other families Classification of Application Fields Terpenoids Source classification Other Diseases Diterpenoids Plants Disease Research Fields	Others
Carboxyatractyloside dipotassium is a toxic natural product, acts as an inhibitor of ADP/ATP carrier, inhibits mitochondrial ADP/ATP transport .

HY-114519

Helenalin acetate 1 Publications Verification	Sesquiterpenes Source classification Derris robusta Plants Compositae	Histone Demethylase NF-κB
Helenalin acetate, a natural NF-κB inhibitor, is a potent C/EBPβ inhibitor. Helenalin acetate has anti-inflammatory and anticancer activities .

HY-N8399

Yadanziolide B	Simaroubaceae Classification of Application Fields Terpenoids Source classification Diterpenoids Plants Disease Research Fields Inflammation/Immunology Brucea javanica (L.) Merr.	Influenza Virus
Yadanziolide B, a natural quassinoid, is a potential H5N1 neuraminidase inhibitor .

HY-N2033

Chebulinic acid 2 Publications Verification	Infection Structural Classification Classification of Application Fields Combretaceae Source classification Phenols Polyphenols Terminalia chebula Retz. Plants Disease Research Fields	DNA/RNA Synthesis TGF-beta/Smad Proton Pump
Chebulinic acid is a potent natural inhibitor of M. tuberculosis DNA gyrase, also can inhibit SMAD-3 phosphorylation, inhibit H+ K+-ATPase activity.

HY-P6294

Pseudostellarin G	Structural Classification Natural Products Pseudostellaria heterophylla (Miq.) Pax Source classification Plants Caryophyllaceae	Tyrosinase
Pseudostellarin G is a natural cyclic octapeptide. Pseudostellarin G has the activity of inhibiting tyrosinase. Pseudostellarin G can inhibit the production of melanin .

HY-N0859

Schisanhenol Schizanhenol; Gomisin-K3	Structural Classification Monophenols Classification of Application Fields Source classification Lignans Phenols Phenylpropanoids Plants Schisandraceae Disease Research Fields Schisandra chinensis (Turcz.) Baill. Cancer	UGT
Schisanhenol is a natural compound solated from Schisandra rubriflora; UGT2B7 UDP-glucuronosyltransferases inhibitor.

HY-B0183A

Ellagic acid (hydrate)	Classification of Application Fields Ziziphus jujuba Source classification Phenols Polyphenols Plants Rhamnaceae Disease Research Fields Cancer	Casein Kinase
Ellagic acid hydrate is a natural antioxidant, and acts as a potent and ATP-competitive CK2 inhibitor, with an IC₅₀ of 40 nM and a K_i of 20 nM .

HY-N0149R

Salicin (Standard)	Structural Classification Natural Products Human Gut Microbiota Metabolites Microorganisms Source classification Plants Endogenous metabolite Salicaceae Salix babylonica Linn.	COX Endogenous Metabolite
Salicin (Standard) is the analytical standard of Salicin. This product is intended for research and analytical applications. Salicin is a natural COX inhibitor.

HY-B0183

Ellagic acid 15+ Cited Publications	Structural Classification Neurological Disease Classification of Application Fields Anti-aging Source classification Plants Endogenous metabolite Microorganisms other families Phenols Polyphenols Disease Research Fields Cancer	Casein Kinase Reactive Oxygen Species Endogenous Metabolite SHP2
Ellagic acid is a natural antioxidant, and acts as a potent and ATP-competitive inhibitor of CK2 and SHP2, with an IC₅₀ of 40 nM and a K_i of 20 nM.

HY-N0168

Hesperetin 10+ Cited Publications	Structural Classification Neurological Disease Classification of Application Fields Source classification Plants Flavonoids Microorganisms other families Sunscreen Flavonones Cosmetic Research Disease Research Fields Cancer	p38 MAPK Autophagy Apoptosis
Hesperetin is a natural flavanone, and acts as a potent and broad-spectrum inhibitor against human UGT activity. Hesperetin regulates apoptosis.

HY-W004291

Methyl arachidate Methyl icosanoate	Structural Classification Natural Products other families Classification of Application Fields Source classification Plants Inflammation/Immunology Disease Research Fields	Aminopeptidase
Methyl arachidate (Methyl eicosanoate), a natural compound, is a leukotriene A4 hydrolase (LTA4H) inhibitor .

HY-N3180

Norbraylin	Toddalia asiatica (L.) Lam. Structural Classification Source classification Rutaceae Coumarins Phenylpropanoids Plants	Phosphodiesterase (PDE)
Norbraylin, a natural prenylated coumarin, is a PDE4D2 inhibitor with an IC₅₀ value of 7.15 μM .

HY-N2392

Kukoamine A 1 Publications Verification	Cardiovascular Disease Alkaloids Structural Classification other families Classification of Application Fields Other Alkaloids Source classification Phenols Polyphenols Plants Disease Research Fields	Parasite
Kukoamine A is a natural occurring spermine derivative, acts as a potent inhibitor of trypanothione reductase (K_i, 1.8 μM), with antihypertensive activity .

HY-N3710

Dehydrocrenatidine Kumujian G; O-Methylpicrasidine I	Alkaloids Simaroubaceae Source classification Pyridine Alkaloids Plants	JAK Apoptosis
Dehydrocrenatidine, a natural alkaloid, is a specific JAK inhibitor. Dehydrocrenatidine inhibits voltage-gated sodium channels and ameliorates mechanic allodia in a rat model of neuropathic pain .

HY-13930

Miquelianin 3 Publications Verification Quercetin 3-O-glucuronide; Quercetin 3-glucuronide	Flavonols Structural Classification Classification of Application Fields Source classification Plants Endogenous metabolite Flavonoids Microorganisms other families Phenols Polyphenols Disease Research Fields Cancer	Endogenous Metabolite
Miquelianin (Quercetin 3-O-glucuronide) is a metabolite of quercetin and a type of natural flavonoid. Miquelianin is also a CBR1 inhibitor.

HY-N1950

Hispidulin 2 Publications Verification Dinatin	Structural Classification Flavonoids Classification of Application Fields Flavones Labiatae Source classification Cassia Phenols Polyphenols Plants Disease Research Fields Cancer	Pim
Hispidulin is a natural flavone with a broad spectrum of biological activities. Hispidulin is a Pim-1 inhibitor with an IC₅₀ of 2.71 μM.

HY-N0125

Diosmetin 5+ Cited Publications	Structural Classification Human Gut Microbiota Metabolites Flavonoids Classification of Application Fields Flavones Citrus limon (L.) Burm. F. Source classification Rutaceae Plants Endogenous metabolite Disease Research Fields Cancer	Cytochrome P450
Diosmetin is a natural flavonoid which inhibits human CYP1A enzyme activity with an IC₅₀ of 40 μM in HepG2 cell.

HY-N8530

Conodurine	Apocynaceae Structural Classification Alkaloids Source classification Tabernaemontana corymbosa Roxburgh ex Wallich Plants Indole Alkaloids	Others
Conodurine is a monoterpenoid indole alkaloid. Conodurine can inhibit lysosomal acidification. Conodurineis isolated from the natural Tabernaemontana corymbosa .

HY-N1405

Cucurbitacin I 10+ Cited Publications Elatericin B; JSI-124; NSC-521777	Triterpenes Structural Classification Classification of Application Fields Terpenoids Cucurbitaceae Plants Disease Research Fields Lagenaria siceraria (Molina) Standl. Cancer	STAT JAK
Cucurbitacin I is a natural selective inhibitor of JAK2/STAT3, with potent anti-cancer activity.

HY-N3789

Dunnianol	Infection Classification of Application Fields Source classification Lignans Illicium dunnianum Tutch. Phenols Polyphenols Illiciaceae Phenylpropanoids Plants Disease Research Fields	Bacterial
Dunnianol is a natural sesqui-neoligan with moderate antibacterial activity. Dunnianol inhibits *Staphylococcus aureus* and *methicillin-resistant Staphylococcus aureus* (MRSA)**.

HY-N9084

9-Hydroxyeriobofuran	Structural Classification Source classification Rosaceae Phenols Polyphenols Plants Pyracantha koidzumii (Hayata) Rehd.	Others
9-Hydroxyeriobofuran is a natural product that can be found in Pyracantha koidzumii. 9-Hydroxyeriobofuran inhibits HEMn cell growth .

HY-N2087

Ligupurpuroside A	Structural Classification Oleaceae Simple Phenylpropanols Source classification Phenylpropanoids Ligustrum expansum Rehder Plants	Lipase
Ligupurpuroside A is an active product that can be extracted from Ligustrum robustum. Ligupurpuroside A acts as a natural inhibitor of lipase in a competitive manner .

HY-N2697

6-Acetonyl-N-methyldihydrodecarine	Structural Classification Alkaloids Source classification Zanthoxylum rigidum Humb. & Bonpl. ex Willd. Rutaceae Plants Isoquinoline Alkaloids	Monoamine Oxidase
6-Acetonyl-N-methyldihydrodecarine is a natural alkaloid that can be isolated from roots of Zanthoxylum rigidum. An inhibitor of monoamine oxidases .

HY-N10549

Gigantol	Structural Classification Natural Products Classification of Application Fields Orchidaceae Other Diseases Glucosinolates Plants Disease Research Fields Dendrobium nobile Lindl.	Others
Gigantol is a natural product that could be isolated from Cymbidium giganteum. Gigantol is a potent inhibitor of the spontaneous contractions of the guinea-pig ileum .

HY-N0862

Harringtonine 10+ Cited Publications	Infection Alkaloids Structural Classification Pyrrole Alkaloids Classification of Application Fields Source classification Plants Cephalotaxaceae Disease Research Fields Cephalotaxus fortunei Hooker	Influenza Virus
Harringtonine is a natural Cephalotaxus alkaloid that inhibits protein synthesis. Harringtonine has anti-chikungunya virus (CHIKV) activities with an EC₅₀ of 0.24 μM.

HY-N10182

Spinacetin	Phyllodium pulchellum (L.) Desv. Structural Classification Flavonols Flavonoids Source classification Plants Compositae	Histamine Receptor
Spinacetin is a natural product that can be isolated from Inula japonica. Spinacetin inhibits the release of histamine. Spinacetin has anti-inflammatory activity .

HY-118328

Hymenidin	Marine natural products Source classification Sponge	5-HT Receptor Potassium Channel
Hymenidin is a natural antagonist of serotonergic receptor and inhibitor of voltage-gated potassium channels. Hymenidin also induces cancer cell apoptosis .

HY-108549

clasto-Lactacystin β-lactone Omuralide; β-Clastolactacystin	Classification of Application Fields Disease Research Fields Cancer	Proteasome
Clasto-Lactacystin β-lactone, a natural active metabolite of lactacystin, which is a metabolite of Streptomyces, acts as an irreversible 20S proteasome inhibitor.

HY-N13137

Timosaponin N	Triterpenes Structural Classification Liliaceae Terpenoids Source classification Anemarrhena asphodeloides Bunge Plants	Glycosidase
Timosaponin N is a natural steroidal saponin that inhibits the activity of α-Glucosidase. Timosaponin N can be used in diabetes-related research .

Cat. No.	Product Name	Chemical Structure

HY-N0125S

Diosmetin-d3
Diosmetin-d₃ is the deuterium labeled Diosmetin. Diosmetin is a natural flavonoid which inhibits human CYP1A enzyme activity with an IC50 of 40 μM in HepG2 cell.

HY-N2392S

Kukoamine A-d8 dihydrochloride
Kukoamine A-d₈ (dihydrochloride) is deuterium labeled Kukoamine A. Kukoamine A is a natural occurring spermine derivative, acts as a potent inhibitor of trypanothione reductase (Ki, 1.8 μM), with antihypertensive activity[1].

HY-N1369S

Menthol-d4
Menthol-d₄ is the deuterium labeled Menthol. Menthol is a natural analgesic compound. Menthol could cause a feeling of coolness due to stimulation of ‘cold’ receptors by inhibiting Ca++ currents of neuronal membranes[1].

HY-N0168S

Hesperetin-d3
Hesperetin-d₃ is the deuterium labeled Hesperetin[1]. Hesperetin is a natural flavanone, and acts as a potent and broad-spectrum inhibitor against human UGT activity. Hesperetin regulates apoptosis[2][3].

HY-B0183S

Ellagic acid-13C12
Ellagic acid- ¹³C₁₂ is ¹³ C-labeled Ellagic acid (HY-B0183). Ellagic acid is a natural antioxidant and acts as a potent and ATP-competitive inhibitor of CK2 and SHP2, with an IC₅₀ of 40 nM and a K_i of 20 nM .

HY-B0134S1

Bestatin-d10
Bestatin-d₁₀ (Ubenimex-d₁₀) is deuterium labeled Bestatin. Bestatin is a natural, broad-spectrum, and competitive CD13 (Aminopeptidase N)/APN and leukotriene A4 hydrolase inhibitor. Bestatin has anticancer effects .

HY-N0168AS

(Rac)-Hesperetin-d3
(Rac)-Hesperetin-d₃ is the deuterium labeled (Rac)-Hesperetin. (Rac)-Hesperetin is the racemate of Hesperetin. Hesperetin is a natural flavanone, and acts as a potent and broad-spectrum inhibitor against human UGT activity. Hesperetin induces apoptosis via p38 MAPK activation.

HY-N1127S

Tricin-d6
Tricin-d₆ is the deuterium labeled Tricin[1]. Tricin is a natural flavonoid present in large amounts in Triticum aestivum. Tricin can inhibit human cytomegalovirus (HCMV) replication by inhibiting CDK9. Tricin inhibits the proliferation and invasion of C6 glioma cells via the upregulation of focal-adhesion-finase (FAK)-targeting microRNA-7[2][3][4].

HY-N0168AS1

(Rac)-Hesperetin-13C,d3
(Rac)-Hesperetin- ¹³C,d₃ is the ¹³C- and deuterium labeled (Rac)-Hesperetin. (Rac)-Hesperetin is the racemate of Hesperetin. Hesperetin is a natural flavanone, and acts as a potent and broad-spectrum inhibitor against human UGT activity. Hesperetin induces apoptosis via p38 MAPK activation.

HY-N8253S

Quercetin 4'-Glucoside-d3
Quercetin 4'-Glucoside-d₃ (Spiraeoside-d₃) is deuterium labeled Spiraeoside. Spiraeoside, an orally active natural compound, exerts antioxidant activity, inhibits reactive oxygen species (ROS) and malondialdehyde production. Spiraeoside possesses antiallergic, anti-inflammatory and antitumor activities .

HY-77813S

Benzyl isothiocyanate-d7
Benzyl isothiocyanate-d₇ is the deuterium labeled Benzyl isothiocyanate. Benzyl isothiocyanate is a member of natural isothiocyanates with antimicrobial activity[1][2]. Benzyl isothiocyanate potent inhibits cell mobility, migration and invasion nature and matrix metalloproteinase-2 (MMP-2) activity of murine melanoma cells[2].

HY-N0005S

Curcumin-d6
Curcumin-d₆is a deuterium labeled Curcumin (Turmeric yellow). Curcumin (Turmeric yellow) is a natural phenolic compound with diverse pharmacologic effects including anti-inflammatory, antioxidant, antiproliferative and antiangiogenic activities. Curcumin is an inhibitor of p300 histone acetylatransferase (HATs) and also shows inhibitory effects on NF-κB and MAPKs.

HY-N0523S

Gallic acid-d2
Gallic acid-d₂ is the deuterium labeled Gallic acid[1]. Gallic acid (3,4,5-Trihydroxybenzoic acid) is a natural polyhydroxyphenolic compound and an free radical scavenger to inhibit cyclooxygenase-2 (COX-2)[2]. Gallic acid has various activities, such as antimicrobial, antioxidant, antimicrobial, anti-inflammatory, and anticance activities[3].

HY-B1550S

Benzoin-d10
Benzoin-d₁₀ (DL-Benzoin-d₁₀) is the deuterium labeled Benzoin (HY-B1550). Benzoin (DL-Benzoin), a natural balsamic resin, is a PI3Kα inhibitor with anticancer effects. Benzoin inihits the growth of colon cancer cell line (HCT-116). Benzoin can be used as a food additive .

HY-18085S1

Quercetin-d3
Quercetin-d₃ is the deuterium labeled Quercetin. Quercetin, a natural flavonoid, is a stimulator of recombinant SIRT1 and also a PI3K inhibitor with IC50 of 2.4 μM, 3.0 μM and 5.4 μM for PI3K γ, PI3K δ and PI3K β, respectively[1].

HY-N1944S

Nerolidol-d4

Nerolidol-d₄ is deuterated labeled Tenuazonic acid (HY-N6715). Tenuazonic acid, belonging to tetramic acids that are the largest family of natural products, is a putative nonhost-selective mycotoxin isolated from Alternaria alternate . Tenuazonic acid blocks electron transport beyond primary quinone acceptor (QA) by interacting with D₁ protein and it is a broad-spectrum and effective photosystem II (PSII) inhibitor .

HY-18085S

Quercetin-d5
Quercetin-d₅ is a deuterium labeled Quercetin. Quercetin, a natural flavonoid, is a stimulator of recombinant SIRT1 and also a PI3K inhibitor with IC50 of 2.4 μM, 3.0 μM and 5.4 μM for PI3K γ, PI3K δ and PI3K β, respectively[1].

HY-N0192S

Arbutin-d4

Arbutin-d₄ is deuterium labeled Arbutin. Arbutin (β-Arbutin) is a competitive inhibitor of tyrosinase in melanocytes, with Kiapp values of 1.42 mM for monophenolase; 0.9 mM for diphenolase. Arbutin is also used as depigmenting agents[1]. Arbutin is a natural polyphenol isolated from the bearberry plant Arctostaphylos uvaursi, possesses with anti-oxidant, anti-inflammatory and anti-tumor properties[2][3].

HY-18085S2

Quercetin-13C3
Quercetin- ¹³C₃ is the ¹³C-labeled Quercetin. Quercetin, a natural flavonoid, is a stimulator of recombinant SIRT1 and also a PI3K inhibitor with IC50 of 2.4 μM, 3.0 μM and 5.4 μM for PI3K γ, PI3K δ and PI3K β, respectively[1].

HY-14649S5

Retinoic acid-d3

Retinoic acid-d₃ is the deuterium labeled Retinoic acid (HY-14649). Retinoic acid is a metabolite of vitamin A that plays important roles in cell growth, differentiation, and organogenesis. Retinoic acid is a natural agonist of RAR nuclear receptors, with IC₅₀s of 14 nM for RARα/β/γ. Retinoic acid bind to PPARβ/δ with Kd of 17 nM. Retinoic acid acts as an inhibitor of transcription factor Nrf2 through activation of retinoic acid receptor alpha .

HY-14649S6

Retinoic acid-d3-1

Retinoic acid-d₃-1 is the deuterium labeled Retinoic acid (HY-14649). Retinoic acid is a metabolite of vitamin A that plays important roles in cell growth, differentiation, and organogenesis. Retinoic acid is a natural agonist of RAR nuclear receptors, with IC₅₀s of 14 nM for RARα/β/γ. Retinoic acid bind to PPARβ/δ with Kd of 17 nM. Retinoic acid acts as an inhibitor of transcription factor Nrf2 through activation of retinoic acid receptor alpha .

HY-14649S2

11-cis-Retinoic Acid-d5

11-cis-Retinoic Acid-d₅ is the deuterium labeled Retinoic acid. Retinoic acid is a metabolite of vitamin A that plays important roles in cell growth, differentiation, and organogenesis. Retinoic acid is a natural agonist of RAR nuclear receptors, with IC50s of 14 nM for RARα/β/γ. Retinoic acid bind to PPARβ/δ with Kd of 17 nM. Retinoic acid acts as an inhibitor of transcription factor Nrf2 through activation of retinoic acid receptor alpha[1][2].

HY-14649S4

Retinoic acid-d5

Retinoic acid-d₅ is the the deuterium labeled Retinoic acid (HY-14649). Retinoic acid is a metabolite of vitamin A that plays important roles in cell growth, differentiation, and organogenesis. Retinoic acid is a natural agonist of RAR nuclear receptors, with IC₅₀s of 14 nM for RARα/β/γ. Retinoic acid bind to PPARβ/δ with K_d of 17 nM. Retinoic acid acts as an inhibitor of transcription factor Nrf2 through activation of retinoic acid receptor alpha .

HY-N8016S2

Nonanal-d2

Nonanal-d₂ is deuterated labeled Methyl cinnamate (HY-W017212). Methyl cinnamate (Methyl 3-phenylpropenoate), an active component of Zanthoxylum armatum, is a widely used natural flavor compound. Methyl cinnamate (Methyl 3-phenylpropenoate) possesses antimicrobial activity and is a tyrosinase inhibitor that can prevent food browning. Methyl cinnamate (Methyl 3-phenylpropenoate) has antiadipogenic activity through mechanisms mediated, in part, by the CaMKK2-AMPK signaling pathway .

HY-14649S3

Retinoic acid-d6

Retinoic acid-d₆ is the deuterium labeled Retinoic acid[1]. Retinoic acid is a metabolite of vitamin A that plays important roles in cell growth, differentiation, and organogenesis. Retinoic acid is a natural agonist of RAR nuclear receptors, with IC50s of 14 nM for RARα/β/γ. Retinoic acid bind to PPARβ/δ with Kd of 17 nM. Retinoic acid acts as an inhibitor of transcription factor Nrf2 through activation of retinoic acid receptor alpha[2][3][4][5][6][7].

HY-N0005S1

Curcumin-d3

Curcumin-d₃ (Diferuloylmethane-d₃ ) is deuterium labeled Curcumin. Curcumin (Diferuloylmethane), a natural phenolic compound, is a p300/CREB-binding protein-specific inhibitor of acetyltransferase, represses the acetylation of histone/nonhistone proteins and histone acetyltransferase-dependent chromatin transcription. Curcumin shows inhibitory effects on NF-κB and MAPKs, and has diverse pharmacologic effects including anti-inflammatory, antioxidant, antiproliferative and antiangiogenic activities. Curcumin induces stabilization of Nrf2 protein through Keap1 cysteine modification.

HY-16561S1

Resveratrol-13C6

Resveratrol- ¹³C₆ is the ¹³C-labeled Resveratrol. Resveratrol (trans-Resveratrol; SRT501), a natural polyphenolic phytoalexin that possesses anti-oxidant, anti-inflammatory, cardioprotective, and anti-cancer properties. Resveratrol (SRT 501) has a wide spectrum of targets including mTOR, JAK, β-amyloid, Adenylyl cyclase, IKKβ, DNA polymerase. Resveratrol also is a specific SIRT1 activator[1][2][3][4]. Resveratrol is a potent pregnane X receptor (PXR) inhibitor[5]. Resveratrol is an Nrf2 activator, ameliorates aging-related progressive renal injury in mice model[6]. Resveratrol increases production of NO in endothelial cells[7].

HY-16561S

Resveratrol-d4

Resveratrol-d₄ is the deuterium labeled Resveratrol. Resveratrol (trans-Resveratrol; SRT501), a natural polyphenolic phytoalexin that possesses anti-oxidant, anti-inflammatory, cardioprotective, and anti-cancer properties. Resveratrol (SRT 501) has a wide spectrum of targets including mTOR, JAK, β-amyloid, Adenylyl cyclase, IKKβ, DNA polymerase. Resveratrol also is a specific SIRT1 activator . Resveratrol is a potent pregnane X receptor (PXR) inhibitor . Resveratrol is an Nrf2 activator, ameliorates aging-related progressive renal injury in mice model . Resveratrol increases production of NO in endothelial cells .

Cat. No.	Product Name		Classification

HY-108039

Bezisterim HE 3286; NE-3107		Alkynes
Bezisterim (HE 3286; NE-3107) is a synthetic derivative of a natural anti-inflammatory steroid, β-AET. Bezisterim is an orally active partial NF-κB inhibitor. HE3286 reduces proinflammatory signals, including IL-6 and matrix metallopeptidase 3. Bezisterim freely penetrates the blood brain barrier in mice. Bezisterim can be used for the research of the ulcerative colitis, arthritis, experimental autoimmune encephalomyelitis . Bezisterim is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-134061

Arecaidine propargyl ester hydrobromide		Alkynes
Arecaidine propargyl ester hydrobromide is an agonist of M2 muscarinic acetylcholine receptors and has the activity of inhibiting tumor cell proliferation. The application of arecaidine propargyl ester hydrobromide has shown that it can reduce the number of ovarian cancer cells in vitro and induce apoptosis and the production of reactive oxygen species (ROS) at specific concentrations. Arecaidine propargyl ester hydrobromide can also arrest cells at the G2/M phase of the cell cycle and increase the percentage of abnormal mitosis. Arecaidine propargyl ester hydrobromide is more sensitizing to ovarian surface epithelial cells with higher M2 receptor levels than to cancer cells. Arecaidine propargyl ester hydrobromide exhibits the effect of lowering arterial blood pressure when interacting with the cardiovascular system in a natural physiological state, indicating its potential pharmacological application .

HY-151829

Fmoc-L-Asn(EDA-N3)-OH		Azide
Fmoc-L-Asn(EDA-N3)-OH is a click chemistry reagent containing an azide group. This building block is reported in literature for the modification of Amanitin via Click Chemistry. Alpha-Amanitin is the deadliest member of the amatoxin peptide family produced by the death-cap mushroom A. phalloides. It is an orally available, rigid, bicyclic octapeptide and one of the most lethal known natural products (LD50 = 50-100 μg/kg) acting as highly selective allosteric inhibitor of the RNA polymerase II . It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.

Cat. No.	Product Name		Classification

HY-N0523A

Gallic acid hydrate 10+ Cited Publications 3,4,5-Trihydroxybenzoic acid hydrate		Antioxidants Chelating Agents Preservatives
Gallic acid (3,4,5-Trihydroxybenzoic acid) hydrate is a natural polyhydroxyphenolic compound and an free radical scavenger to inhibit cyclooxygenase-2 (COX-2) . Gallic acid hydrate has various activities, such as antimicrobial, antioxidant, antimicrobial, anti-inflammatory, and anticance activities .

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