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Results for "

Neuraminidase Inhibitors

" in MCE Product Catalog:

38

Inhibitors & Agonists

8

Natural
Products

6

Isotope-Labeled Compounds

Cat. No. Product Name Target Research Areas
  • HY-144420
    Neuraminidase-IN-5

    Influenza Virus Infection
    Neuraminidase-IN-5 (Compound 5b) is a potent inhibitor of neuraminidase with an IC50 of 0.02 μM. Neuraminidase (NA) is a promising target for development of anti-influenza drugs. Neuraminidase-IN-5 is a dihydrofurocoumarin derivative compound.
  • HY-143488
    Neuraminidase-IN-8

    Influenza Virus Infection
    Neuraminidase-IN-8 (Compound 6d) is a potent neuraminidase inhibitor with an IC50 of 0.027 µM. Neuraminidase-IN-8 shows anti-influenza activities.
  • HY-137334
    Neuraminidase-IN-1

    Influenza Virus Infection
    Neuraminidase-IN-1 is a neuraminidase inhibitor, with an IC50 of 0.21 μM. Neuraminidase-IN-1 has excellent activity against H1N1 influenza virus.
  • HY-144426
    Neuraminidase-IN-6

    Influenza Virus Infection
    Neuraminidase-IN-6 (Compound 5c) is a potent inhibitor of neuraminidase with an IC50 of 0.11 μM. Neuraminidase-IN-6 is a 1,3,4-triazole-3-acetamide derivative. Neuraminidase (NA) is an ideal target for the development of anti-influenza drugs.
  • HY-144103
    Neuraminidase-IN-4

    Influenza Virus Infection
    Neuraminidase-IN-4 (Compound 4b) is a potent inhibitor of neuraminidase with an EC50 of 1.59 μM. Neuraminidase (NA) is an important target for the treatment of influenza. Neuraminidase-IN-4 exhibits excellent antiviral activity against A/chicken/Hubei/327/2004 (H5N1-DW).
  • HY-143453
    Neuraminidase-IN-7

    Influenza Virus Infection
    Neuraminidase-IN-7 (compound 4b), a thiophene derivative, is a potent neuraminidase inhibitor with an IC50 of 0.03 μM. Neuraminidase-IN-7 also exhibits excellent antiviral activity against A/chicken/Hubei/327/2004 (H5N1-DW) (EC50=1.59 μM). Neuraminidase-IN-7 has the potential for influenza research.
  • HY-129150
    Ganoderic acid TR

    Influenza Virus Infection
    Ganoderic acid TR is a broad-spectrum inhibitor against influenza neuraminidases (NAs), particularly H5N1 and H1N1 neuraminidases. The IC50 values of 10.9 and 4.6 μM, respectively.
  • HY-17016
    Oseltamivir phosphate

    GS 4104

    Influenza Virus Infection
    Oseltamivir phosphate (GS 4104) is a neuraminidase inhibitor recommended for the treatment and prophylaxis of influenza A and B.
  • HY-N0243
    Theaflavin

    Influenza Virus Endogenous Metabolite Infection
    Theaflavin is a suitable natural inhibitor against influenza A (H1N1) neuraminidase.
  • HY-N10298
    Massarilactone H

    Influenza Virus Infection
    Massarilactone H, a polyketide, is a neuraminidase inhibitor, with an IC50 of 8.18 µM.
  • HY-N8399
    Yadanziolide B

    Influenza Virus Infection Inflammation/Immunology
    Yadanziolide B, a natural quassinoid, is a potential H5N1 neuraminidase inhibitor.
  • HY-146306
    Neuraminidase-IN-9

    Influenza Virus Infection
    Neuraminidase-IN-9 (Compound 6l) is a potent influenza neuraminidase inhibitor with IC50 values of 0.12, 0.049 and 0.16 µM against H5N1, H5N2 and H5N6, respectively.
  • HY-139991
    Neuraminidase-IN-3

    Influenza Virus Infection
    Neuraminidase-IN-3 (compound 23d) is a potent influenza neuraminidase (NA) inhibitor with IC50 values of 0.73, 0.26, and 0.63 nM against H1N1, H5N1, and H5N8 NAs, respectively.
  • HY-13210
    Zanamivir

    Influenza Virus Antibiotic Infection
    Zanamivir is an influenza viral neuraminidase inhibitor with IC50 values of 0.95 nM and 2.7 nM for influenza A and B, respectively.
  • HY-141862
    Zanamivir-Cholesterol Conjugate

    Influenza Virus Infection
    Zanamivir–cholesterol conjugate is a long-acting neuraminidase inhibitor with potent efficacy against drug-resistant influenza viruses.
  • HY-43575
    Oseltamivir-acetate

    Influenza Virus Infection
    Oseltamivir-acetate is an impurity of Oseltamivir. Oseltamivir is a neuraminidase inhibitor recommended for the treatment and prophylaxis of influenza A and B.
  • HY-147331
    Oseltamivir acid methyl ester

    Others Neurological Disease
    Oseltamivir acid methyl ester is a prodrug form of the neuraminidase inhibitor and antiviral oseltamivir acid. Oseltamivir acid methyl ester is converted to oseltamivir acid by carboxylesterase 1 (CES1) .
  • HY-13210A
    Zanamivir (hydrate)(5:1)

    Antibiotic Influenza Virus Infection
    Zanamivir hydrate (5:1) is the hydrate of Zanamivir. Zanamivir is an influenza viral neuraminidase inhibitor with IC50 values of 0.95 nM and 2.7 nM for influenza A and B, respectively.
  • HY-N9919
    Glyasperin C

    Others Others
    Glyasperin C is a potent and reversible noncompetitive inhibitor of neuraminidase with an IC50 of 20% at 200 μM. Glyasperin C is a polyphenol isolated from the roots of Glycyrrhiza uralensis.
  • HY-146004
    Influenza A virus-IN-4

    Influenza Virus Infection
    Influenza A virus-IN-4 (compound 23b), an Oseltamivir derivative, is a potent inhibitor of neuraminidase. Influenza A virus-IN-4 exerts powerful inhibitions on influenza viruses.
  • HY-17016S1
    Oseltamivir-d3 phosphate

    GS 4104-d3 phosphate

    Influenza Virus Infection
    Oseltamivir-d3 (GS 4104-d3) phosphateis the deuterium labeled Oseltamivir phosphate. Oseltamivir phosphate (GS 4104) is a neuraminidase inhibitor recommended for the treatment and prophylaxis of influenza A and B.
  • HY-17016S
    Oseltamivir-d5 phosphate

    GS 4104-d5

    Influenza Virus Infection
    Oseltamivir-d5 phosphate (GS 4104-d5) is the deuterium labeled Oseltamivir phosphate. Oseltamivir phosphate (GS 4104) is a neuraminidase inhibitor recommended for the treatment and prophylaxis of influenza A and B.
  • HY-125798
    2,3-Dehydro-2-deoxy-N-acetylneuraminic acid

    Neu5Ac2en; DANA

    Influenza Virus Infection
    N-acetyl-2,3-dehydro-2-Deoxyneuraminic Acid (Neu5Ac2en) is a potent neuraminidase (sialidase) inhibitor. N-acetyl-2,3-dehydro-2-Deoxyneuraminic Acid shows inhibitory activities against human neuraminidase enzymes with IC50s of 143, 43, 61, and 74 μM for NEU1, NEU2, NEU3, and NEU4, respectively. Anti-influenza virus activity.
  • HY-13318
    Oseltamivir acid

    GS 4071; Ro 64-0802; Oseltamivir carboxylate

    Influenza Virus Drug Metabolite Infection
    Oseltamivir acid (GS 4071), the active metabolite of Oseltamivir phosphate, is an orally bioavailable, potent and selective inhibitor of influenza virus neuraminidase (IC50=2 nM) with activity against both influenza A and B viruses.
  • HY-N2394
    Emodin-1-O-β-D-glucopyranoside

    Others Inflammation/Immunology
    Emodin-1-O-β-D-glucopyranoside, isolated from medicinal plant Polygonum cuspidatum Sieb. & Zucc, is a potent and noncompetitive bacterial neuraminidase (BNA) inhibitor with an IC50 of 0.85 μM.
  • HY-17015A
    Peramivir

    RWJ-270201; BCX-1812

    Influenza Virus Infection
    Peramivir (RWJ-270201;BCX-1812) is a highly potent, selective and orally active influenza virus neuraminidase (NA) inhibitor, with IC50 values ranging form 0.9 to 4.3 nM for nine NA subtypes.
  • HY-146001
    Influenza virus-IN-4

    Influenza Virus Inflammation/Immunology
    Influenza virus-IN-4 (compound 11e) is a potent influenza virus neuraminidase inhibitor with IC50s of 3.4, 0.094, 0.79, 0.077 µM for H5N1, H5N2, H5N6, H5N8, respectively. Influenza virus-IN-4 shows NA (neuraminidase enzyme)-inhibitory activity. Influenza virus-IN-4 shows low cytotoxicity with an CC50 of >200 µM. Influenza virus-IN-4 shows no obvious toxicity at the dose of 1500 mg/kg in mice.
  • HY-122575
    Aurintricarboxylic acid

    P2X Receptor Influenza Virus Topoisomerase MicroRNA Apoptosis Infection Inflammation/Immunology Neurological Disease
    Aurintricarboxylic acid is a nanomolar-potency, allosteric antagonist with selectivity towards αβ-methylene-ATP-sensitive P2X1Rs and P2X3Rs, with IC50s of 8.6 nM and 72.9 nM for rP2X1R and rP2X3R, respectively. Aurintricarboxylic acid is a potent anti-influenza agent by directly inhibiting the neuraminidase. Aurintricarboxylic acid is an inhibitor of topoisomerase II and apoptosis. Aurintricarboxylic acid is a selective inhibitor of the TWEAK-Fn14 signaling pathway. Aurintricarboxylic acid also acts as a cystathionine-lyase (CSE) inhibitor with an IC50 of 0.6 μM. Aurintricarboxylic acid is a modifier of miRNAs that regulate miRNA function, with an IC50 of 0.47 µM.
  • HY-17015
    Peramivir trihydrate

    RWJ 270201 trihydrate; BCX 1812 trihydrate

    Influenza Virus Infection
    Peramivir trihydrate (RWJ-270201 trihydrate;BCX-1812 trihydrate) is a highly potent, selective and orally active influenza virus neuraminidase (NA) inhibitor, with IC50 values ranging from 0.9 to 4.3 nM for nine NA subtypes.
  • HY-14818A
    Laninamivir octanoate

    CS-8958

    Influenza Virus Infection
    Laninamivir octanoate (CS-8958), a prodrug of Laninamivir, is a long-acting neuraminidase (NA) inhibitor with anti-influenza virus activity. Laninamivir octanoate shows anti-influenza activity against Oseltamivir-resistant viruses, and also against the pandemic influenza viruses.
  • HY-13318S
    Oseltamivir acid-d3

    GS 4071-d3; Ro 64-0802-d3; Oseltamivir carboxylate-d3

    Influenza Virus Infection
    Oseltamivir acid D3 (GS 4071 D3) is a deuterium labeled Oseltamivir acid. Oseltamivir acid, the active metabolite of Oseltamivir phosphate, is an orally bioavailable, potent and selective inhibitor of influenza virus neuraminidase (IC50=2 nM) with activity against both influenza A and B viruses.
  • HY-N0736
    Coptisine chloride

    Indoleamine 2,3-Dioxygenase (IDO) Bacterial Influenza Virus Cancer Infection Metabolic Disease
    Coptisine chloride is an alkaloid from Chinese goldthread, and acts as an efficient uncompetitive IDO inhibitor with a Ki value of 5.8 μM and an IC50 value of 6.3 μM. Coptisine chloride is a potent H1N1 neuraminidase (NA-1) inhibitor with an IC50 of 104.6 μg/mL and can be used for influenza A (H1N1) infection.
  • HY-N2533
    Cyanidin 3-sambubioside chloride

    Cyanidin-3-O-sambubioside chloride

    Influenza Virus Angiotensin-converting Enzyme (ACE) Cancer Infection Inflammation/Immunology
    Cyanidin 3-sambubioside chloride (Cyanidin-3-O-sambubioside chloride), a major anthocyanin, a natural colorant, and is a potent NO inhibitor. Cyanidin 3-sambubioside chloride is a H274Y mutation inhibitor, and inhibits influenza neuraminidase activity with an IC50 of 72 μM. Cyanidin 3-sambubioside chloride inhibits angiotensin-converting enzyme (ACE) activity and has antioxidant, anti-angiogenic and antiviral properties.
  • HY-14818AS
    Laninamivir octanoate-d3

    CS-8958-d3

    Influenza Virus Infection
    Laninamivir octanoate-d3 (CS-8958-d3) is the deuterium labeled Laninamivir octanoate. Laninamivir octanoate (CS-8958), a prodrug of Laninamivir, is a long-acting neuraminidase (NA) inhibitor with anti-influenza virus activity. Laninamivir octanoate shows anti-influenza activity against Oseltamivir-resistant viruses, and also against the pandemic influenza viruses.
  • HY-13317S
    Oseltamivir-d3

    Influenza Virus Infection
    Oseltamivir D3 is a deuterium labeled Oseltamivir. Oseltamivir is an influenza virus neuraminidase inhibitor (NAI). Oseltamivir inhibits influenza A/H3N2, A/H1N2, A/H1N1, and B viruses with mean IC50s of 0.67, 0.9, 1.34 and 13 nM, respectively. Anti-influenza A and B agent.
  • HY-14818
    Laninamivir

    R 125489

    Influenza Virus Infection
    Laninamivir (R 125489) is a potent influenza neuraminidase (NA) inhibitor with IC50s of 0.90 nM, 1.83 nM and 3.12 nM for avian H12N5 NA (N5), pH1N1 N1 NA (p09N1) and A/RI/5+/1957 H2N2 N2 (p57N2), respectively.
  • HY-146000
    Influenza virus-IN-3

    Influenza Virus Inflammation/Immunology
    Influenza virus-IN-3 (compound 9) is a potent and selective influenza virus inhibitor with IC50s of 0.88, 0.10, 5.5, 0.51 µM for H5N1, H5N2, H5N6, H5N8, respectively. Influenza virus-IN-3 shows antiviral and NA (neuraminidase enzyme)-inhibitory activity. Influenza virus-IN-3 shows low cytotoxicity with an CC50 of >200 µM.
  • HY-14818S
    Laninamivir-d3

    Influenza Virus Infection
    Laninamivir-d3 (R 125489-d3) is the deuterium labeled Laninamivir. Laninamivir (R 125489) is a potent influenza neuraminidase (NA) inhibitor with IC50s of 0.90 nM, 1.83 nM and 3.12 nM for avian H12N5 NA (N5), pH1N1 N1 NA (p09N1) and A/RI/5+/1957 H2N2 N2 (p57N2), respectively.