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Results for "

Neurokinin Receptor

" in MCE Product Catalog:

By Targets:	Neurokinin Receptor (63) Antibiotic (1) Bacterial (1) Cytochrome P450 (1) Endogenous Metabolite (3) HIV (1) Isotope-Labeled Compounds (2)
By Research Areas:	Cancer (15) Endocrinology (35) Infection (1) Inflammation/Immunology (4) Metabolic Disease (1) Neurological Disease (53)

Inhibitors & Agonists

Peptides

Inhibitory Antibodies

Natural
Products

Isotope-Labeled Compounds

Targets Recommended: Neurokinin Receptor

Cat. No.	Product Name	Target	Research Areas

HY-P3852

Neurokinin Receptor (393-407), rat SPR393-407	Neurokinin Receptor	Inflammation/Immunology Neurological Disease
Neurokinin Receptor (393-407), rat (SPR393–407) is a rat neurokinin 1 receptor (NK1R) fragment. NK1R is rapidly internalized by endocytosis and recycled to the plasma membrane when binding to substance P (SP). Neurokinin Receptor (393-407), rat can be used in the research of neurogenic inflammation.

HY-109147A

Imnopitant dihydrochloride
Neurokinin Receptor Neurological Disease

Imnopitant dihydrochloride is a neurokinin NK1 receptor antagonist.

Imnopitant dihydrochloride	Neurokinin Receptor	Neurological Disease
Imnopitant dihydrochloride is a neurokinin NK1 receptor antagonist.

HY-118463

Benzomalvin A	Neurokinin Receptor	Neurological Disease
Benzomalvin A is a potent antagonist of **neurokinin receptor** isolated from Penicillium sp. Benzomalvin A shows inhibitory activity against substance P with K_i values of 12, 42 and 43 μM at the guinea pig, rat and human neurokinin NK1 receptors, respectively.

HY-151413

MEN 10207	Neurokinin Receptor	Neurological Disease
MEN 10207 is a selective NK-2 tachykinin receptor (Neurokinin Receptor)?antagonist. MEN 10207 has pA₂ values of 5.2, 7.9 and 4.9 in three monoreceptor in vitro assays for NK-1, NK-2 and NK-3 tachykinin receptors, respectively.

HY-P1588

Scyliorhinin II	Neurokinin Receptor	Neurological Disease Endocrinology
Scyliorhinin II is a selective **neurokinin-3 receptor agonist, with a K_i** of 2.5 nM for neurokinin-3 receptor in rat cerebral cortex.

HY-P3862

[MePhe7]-Neurokinin B	Neurokinin Receptor	Endocrinology Neurological Disease
[MePhe7]-Neurokinin B is an **neurokinin NK-3 receptor (NK3R) agonist with an IC₅₀** value of 3 nM. [MePhe7]-Neurokinin B is a potential regulator of pulsatile gonadotropin-releasing hormone (GnRH) secretion via activation of the neurokinin-3 receptor (NK3R).

HY-P1031

[bAla8]-Neurokinin A(4-10)
MEN 10210
Neurokinin Receptor Endocrinology

[bAla8]-Neurokinin A(4-10) is a neurokinin 2 (NK2) receptor agonist.

[bAla8]-Neurokinin A(4-10) MEN 10210	Neurokinin Receptor	Endocrinology
[bAla8]-Neurokinin A(4-10) is a **neurokinin 2 (NK2) receptor** agonist.

HY-P3851

(β-Ala8)-Neurokinin A (4-10)	Neurokinin Receptor	Neurological Disease
(β-Ala8)-Neurokinin A (4-10), a neuropeptide, is a potent and selective NK-2 tachykinin receptor (Neurokinin *Receptor*) agonist.

HY-P0061

Vapreotide
RC160; BMY 41606
Neurokinin Receptor Cancer

Vapreotide is a neurokinin-1 (NK1) receptor antagonist, with an IC₅₀ of 330 nM.
HY-12114

Serlopitant
VPD-737; MK-0594
Neurokinin Receptor Neurological Disease Endocrinology

Serlopitant is a selective Neurokinin-1 (NK-1) receptor antagonist.
HY-14432

Pavinetant
MLE-4901; AZD2624; AZD4901
Neurokinin Receptor Neurological Disease Endocrinology

Pavinetant (MLE-4901) is a neurokinin-3 receptor (NK3R) antagonist.

Vapreotide RC160; BMY 41606	Neurokinin Receptor	Cancer
Vapreotide is a **neurokinin-1 (NK1) receptor antagonist, with an IC₅₀** of 330 nM.

Serlopitant VPD-737; MK-0594	Neurokinin Receptor	Neurological Disease Endocrinology
Serlopitant is a selective Neurokinin-1 (NK-1) receptor antagonist.

Pavinetant MLE-4901; AZD2624; AZD4901	Neurokinin Receptor	Neurological Disease Endocrinology
Pavinetant (MLE-4901) is a **neurokinin-3 receptor (NK3R**) antagonist.

HY-P1030

Hemokinin 1 (mouse)	Neurokinin Receptor	Endocrinology
Hemokinin 1 (mouse) is a selective agonist of **neurokinin-1 receptor, with K_i** of 0.175 nM and 560 nM for human NK1 receptor and human NK2 receptor, respectively.

HY-P0201

Substance P Neurokinin P	Neurokinin Receptor Endogenous Metabolite	Neurological Disease Endocrinology Cancer
Substance P (Neurokinin P) is a neuropeptide, acting as a neurotransmitter and as a neuromodulator in the CNS. The endogenous receptor for substance P is **neurokinin 1 receptor** (NK1-receptor, NK1R).

HY-P0255

Physalaemin
Neurokinin Receptor Neurological Disease Endocrinology

Physalaemin, a non-mammalian tachykinin, binds selectively to neurokinin-1 (NK1) receptor with high affinity.

Physalaemin	Neurokinin Receptor	Neurological Disease Endocrinology
Physalaemin, a non-mammalian tachykinin, binds selectively to *neurokinin-1* (NK1) *receptor* with high affinity.

HY-122347A

Orvepitant maleate GW823296 maleate	Neurokinin Receptor	Neurological Disease
Orvepitant maleate (GW823296 maleate) is potent, selective, orally active and well-tolerated neurokinin-1 receptor (NK-1) antagonist with a pK_i of 10.2 for human neurokinin-1 receptor. Orvepitant maleate can across the blood-brain barrier. Orvepitant maleate has the potential for depressive disorder and chronic refractory cough (CRC) treatment.

HY-P3850

(D-Pro2,D-Trp6,8,Nle10)-Neurokinin B	Neurokinin Receptor	Neurological Disease
(D-Pro2,D-Trp6,8,Nle10)-Neurokinin B is a competitive antagonist of Neurokinin B (Neurokinin *Receptor) with a pA2 of 5.5. (D-Pro2,D-Trp6,8,Nle10)-Neurokinin* B shows no influence on Substance P or Neurokinin A.

HY-P0061A

Vapreotide acetate RC-160 acetate; BMY-41606 acetate	Neurokinin Receptor	Cancer
Vapreotide acetate (RC-160 acetate; BMY-41606 acetate) is a **neurokinin-1 (NK1) receptor antagonist, with an IC₅₀** of 330 nM.

HY-P0201A

Substance P TFA Neurokinin P TFA	Neurokinin Receptor Endogenous Metabolite	Endocrinology Neurological Disease Cancer
Substance P TFA (Neurokinin P TFA) is a neuropeptide, acting as a neurotransmitter and as a neuromodulator in the CNS. The endogenous receptor for substance P is **neurokinin 1 receptor** (NK1-receptor, NK1R).

HY-P1276

Men 10376 Neurokinin-2 Receptor antagonist	Neurokinin Receptor	Endocrinology
Men 10376 is a selective tachykinin NK-2 receptor antagonist, with a K_i of 4.4 μM for rat small intestine NK-2 receptor.

HY-P0242

Neurokinin B	Neurokinin Receptor	Neurological Disease Endocrinology
Neurokinin B belongs to the tachykinin family of peptides. Neurokinin B binds a family of GPCRs-including neurokinin receptor 1 (NK1R), NK2R, and NK3R-to mediate their biological effect.

HY-P0242A

Neurokinin B TFA	Neurokinin Receptor	Neurological Disease Endocrinology
Neurokinin B TFA belongs to the tachykinin family of peptides. Neurokinin B binds a family of GPCRs-including neurokinin receptor 1 (NK1R), NK2R, and NK3R-to mediate their biological effect.

HY-P2546

Biotin-Substance P	Neurokinin Receptor	Neurological Disease
Biotin-Substance P is the biotin tagged Substance P. Substance P (Neurokinin P) is a neuropeptide, acting as a neurotransmitter and as a neuromodulator in the CNS. The endogenous receptor for substance P is neurokinin 1 receptor (NK1-receptor, NK1R).

HY-P0236

Neurokinin A(4-10)
Neurokinin Receptor Neurological Disease Endocrinology

Neurokinin A (4-10) is a tachykinin NK₂ receptor agonist.

Neurokinin A(4-10)	Neurokinin Receptor	Neurological Disease Endocrinology
Neurokinin A (4-10) is a tachykinin NK₂ receptor agonist.

HY-P0197

Neurokinin A Substance K; Neurokinin α; Neuromedin L	Neurokinin Receptor	Neurological Disease Endocrinology
Neurokinin A (Substance K), a peptide neurotransmitter of the tachykinin family, acts via the NK-2 receptor. Neurokinin A acts as a major mediator in human airway and gastrointestinal tissues.

HY-109171

Elinzanetant
NT-814; BAY3427080
Neurokinin Receptor Neurological Disease

Elinzanetant is a neurokinin receptors antagonist used for the research of Schizophrenia.

Elinzanetant NT-814; BAY3427080	Neurokinin Receptor	Neurological Disease
Elinzanetant is a **neurokinin receptors** antagonist used for the research of Schizophrenia.

HY-16346S

Netupitant-d6 CID-6451149-d₆	Neurokinin Receptor	Endocrinology Neurological Disease
Netupitant-d₆ is the deuterium labeled Netupitant (CID-6451149), which is a highly potent and selective, orally active neurokinin-1 (NK1) receptor antagonist[1].

HY-14407

Fosaprepitant L-758298	Neurokinin Receptor	Neurological Disease Endocrinology Cancer
Fosaprepitant (L-785298) is a proagent of Aprepitant (HY-10052). Fosaprepitant is a **neurokinin-1 receptor** antagonist, which is development for the prevention of chemotherapy-induced nausea and vomiting (CINV).

HY-P0197A

Neurokinin A TFA Substance K TFA; Neurokinin α TFA; Neuromedin L TFA	Neurokinin Receptor	Endocrinology Neurological Disease
Neurokinin A TFA (Substance K TFA), a peptide neurotransmitter of the tachykinin family, acts via the NK-2 receptor. Neurokinin A acts as a major mediator in human airway and gastrointestinal tissues.

HY-105436

FR 113680
Neurokinin Receptor Neurological Disease

FR 113680 is a tripeptide substance P antagonist that interacts selectively with the NK₁ neurokinin receptor.

FR 113680	Neurokinin Receptor	Neurological Disease
FR 113680 is a tripeptide substance P antagonist that interacts selectively with the NK₁ neurokinin receptor.

HY-P3849

[Lys5,MeLeu9,Nle10]Neurokinin A(4-10) LMN-NKA	Neurokinin Receptor	Neurological Disease
[Lys5,MeLeu9,Nle10]Neurokinin A(4-10) (LMN-NKA), an analogue of Neurokinin A, is a selective and potent NK2R agonist. [Lys5,MeLeu9,Nle10]Neurokinin A(4-10) has prokinetic activity. [Lys5,MeLeu9,Nle10]Neurokinin A(4-10) can be used to study the roles of the NK-2 receptor in smooth muscle contraction in numerous tissues.

HY-P0236A

Neurokinin A(4-10) TFA
Neurokinin Receptor Neurological Disease Endocrinology

Neurokinin A (4-10) TFA is a tachykinin NK₂ receptor agonist.

Neurokinin A(4-10) TFA	Neurokinin Receptor	Neurological Disease Endocrinology
Neurokinin A (4-10) TFA is a tachykinin NK₂ receptor agonist.

HY-14407A

Fosaprepitant dimeglumine MK-0517; L785298	Neurokinin Receptor	Neurological Disease Endocrinology Cancer
Fosaprepitant dimeglumine (MK-0517) is a proagent of Aprepitant (HY-10052). Fosaprepitant dimeglumine is a **neurokinin-1 receptor** antagonist, which is development for the prevention of chemotherapy-induced nausea and vomiting (CINV).

HY-P1276A

Men 10376 TFA Neurokinin-2 Receptor antagonist TFA	Neurokinin Receptor	Endocrinology
Men 10376 TFA is a selective tachykinin NK-2 receptor antagonist, with a K_i of 4.4 μM for rat small intestine NK-2 receptor.

HY-18006

NKP608	Neurokinin Receptor	Neurological Disease Endocrinology
NKP608 is a non-peptidic derivative of 4-aminopiperidine which acts as a selective, specific and potent antagonist at the neurokinin-1 (NK-1) receptor both in vitro(IC50=2.6 nM) and in vivo.

HY-16346

Netupitant CID 6451149	Neurokinin Receptor	Neurological Disease Endocrinology
Netupitant (CID-6451149) is a highly potent, selective and orally active neurokinin-1 (NK₁) receptor antagonist with a K_i of 0.95 nM for hNK₁ in CHO cells. Netupitant has antiemetic affect.

HY-19632

Fezolinetant
ESN-364
Neurokinin Receptor Endocrinology

Fezolinetant is an antagonist of the neurokinin 3 receptor (NK3R), used for the treatment of menopausal hot flushes.

Fezolinetant ESN-364	Neurokinin Receptor	Endocrinology
Fezolinetant is an antagonist of the neurokinin 3 receptor (NK3R), used for the treatment of menopausal hot flushes.

HY-10052

Aprepitant MK-0869; MK-869; L-754030	Neurokinin Receptor Bacterial HIV Antibiotic	Neurological Disease Endocrinology Cancer
Aprepitant (MK-0869) is a selective and high-affinity **neurokinin 1 receptor antagonist with a K_d** of 86 pM.

HY-P3861

Biotin-NeurokininA	Neurokinin Receptor	Neurological Disease
Biotin-NeurokininA is a biotinylated NeurokininA (HY-P0197). Neurokinin A (Substance K), a peptide neurotransmitter of the tachykinin family, acts via the NK-2 receptor. Neurokinin A acts as a major mediator in human airway and gastrointestinal tissues.

HY-119552

Acetylaszonalenin LL-S490β	Endogenous Metabolite Neurokinin Receptor	Neurological Disease
Acetylaszonalenin, a prenylated indole derivative, is a fungal metabolite.Acetylaszonalenin is a potent neurokinin-1 (NK1) receptor antagonist. Acetylaszonalenin shows inhibition of [³H]-SP binding to human astrocytoma cells with a K_i of 170 μM.

HY-U00392

Tachykinin angatonist 1	Neurokinin Receptor	Neurological Disease Endocrinology
Tachykinin angatonist 1 is a **neurokinin receptor** antagonist extracted from patent US5968923, compound example 32.

HY-P1738

[Sar9] Substance P
Neurokinin Receptor Neurological Disease Endocrinology

[Sar9] Substance P is a potent and selective neurokinin (NK)-1 receptor agonist.

[Sar9] Substance P	Neurokinin Receptor	Neurological Disease Endocrinology
[Sar9] Substance P is a potent and selective **neurokinin (NK)-1 receptor** agonist.

HY-14407AS

Fosaprepitant-d4 dimeglumine MK-0517-d₄; L785298-d₄	Isotope-Labeled Compounds Neurokinin Receptor	Neurological Disease Endocrinology Cancer
Fosaprepitant-d₄ (dimeglumine) is deuterium labeled Fosaprepitant (dimeglumine). Fosaprepitant dimeglumine (MK-0517) is a proagent of Aprepitant (HY-10052). Fosaprepitant dimeglumine is a neurokinin-1 receptor antagonist, which is development for the prevention of chemotherapy-induced nausea and vomiting (CINV)[1].

HY-19633

CS-003 Free base	Neurokinin Receptor	Infection Endocrinology
CS-003 Free base (CS-003), a triple tachykinin receptor antagonist, shows high affinities for human (Neurokinin) NK1, NK2 and NK3 receptors with K_i values of 2.3 nM, 0.54 nM and 0.74 nM, respectively. CS-003 Free base (CS-003) has therapeutic efficacy on respiratory diseases associated with neurokinins.

HY-P3069

γ-Neuropeptide (rabbit)	Neurokinin Receptor	Endocrinology Neurological Disease
γ-Neuropeptide (rabbit) can be isolated from rabbit intestine. γ-Neuropeptide is an endogenous neurokinin peptide that acts as a **neurokinin 2 (NK2) receptor** agonist. γ-Neuropeptide mediates hypothalamic-pituitary-adrenal (HPA) axis, as well as reproductive hormone release.

HY-101249

L-732138	Neurokinin Receptor	Cancer Neurological Disease
L-732138 is a selective, potent and competitive **neurokinin-1 (NK-1) receptor antagonist with an IC₅₀** of 2.3 nM. L-732138 has 200-fold more potent in cloned human NK-1 receptors than cloned rat NK-1 receptors, and has > 1000-fold more potent than human NK-2 and NK-3 receptors. L-732138 can reduce hyperalgesia and has antitumor action.

HY-P1722

Spantide II	Neurokinin Receptor	Inflammation/Immunology
Spantide II, an undecapeptide substance P (SP) analog, is a potent neurokinin-1 receptor (NK-1R) antagonist. Spantide II binds with NK-1R and blocks proinflammatory activities associated with SP. Spantide II can be used in the research of inflammatory skin disorders, such as psoriasis and contact dermatitis.

HY-19456

SSR-241586	Neurokinin Receptor	Neurological Disease Endocrinology
SSR-241586 is an antagonist of **neurokinin receptors**. SSR-241586 is shown to be active in the treatment of depression, schizophrenia, urinary trouble, emesis, and irritable bowel syndrome (IBS).

HY-P1198

Hemokinin 1, human	Neurokinin Receptor	Neurological Disease
Hemokinin 1, human is a selective tachykinin neurokinin 1 (NK1) receptor full agonist. Hemokinin 1, human is a full agonist at NK2 and NK3 receptor. Hemokinin 1, human can produces an opioid-independent analgesia.

HY-P3802

[D-Trp2,7,9] Substance P	Neurokinin Receptor	Neurological Disease
[D-Trp2,7,9] Substance P is a tachykinin (Neurokinin *Receptor) antagonist with K_i* values of 1 μM, 1.3 μM, and ~9 μM for NK-1, NK-2,and NK-3 receptor, respectively.

HY-P1192

GR-73632	Neurokinin Receptor	Neurological Disease Endocrinology
GR-73632 is a novel tachykinin neurokinin 1 (NK-1) receptor agonist. GR-73632 acts directly on the peripheral terminals of primary sensory neurons through NK1 receptor which convey itch signals.

HY-P1198A

Hemokinin 1, human TFA	Neurokinin Receptor	Neurological Disease
Hemokinin 1, human TFA is a selective tachykinin neurokinin 1 (NK1) receptor full agonist. Hemokinin 1, human TFA is a full agonist at NK2 and NK3 receptor. Hemokinin 1, human TFA can produces an opioid-independent analgesia.

HY-10053

Maropitant	Neurokinin Receptor	Neurological Disease Endocrinology
Maropitant is a selective and orally active **neurokinin (NK1) receptor** antagonist. Maropitant acts by blocking the binding of substance P within the emetic center and the chemoreceptor trigger zone (CRTZ). Maropitant is highly effective in preventing vomiting.

HY-B2078A

Eprazinone dihydrochloride	Neurokinin Receptor	Inflammation/Immunology
Eprazinone dihydrochloride is a gent with mucolytic, secretolytic, antitussive, and bronchial antispasmodic properties. Eprazinone dihydrochloride is a neurokinin 1 receptor (NK1R) ligand. Eprazinone dihydrochloride has the potential for chronic bronchitis treatment that improved pulmonary function and arterial partial pressure of oxygen.

HY-12143

Vofopitant dihydrochloride GR 205171A	Neurokinin Receptor	Cancer Neurological Disease Endocrinology
Vofopitant dihydrochloride (GR 205171A) is a potent, selective and orally available tachykinin neurokinin 1(NK1) receptor antagonist, inhibits [³H]SP binding to the NK1 receptor with pK_i values of 9.5 and 10.6 in rat and human membranes respectively, acts as a potential broad-spectrum anti-emetic agent.

HY-P3854

GR 83074	Neurokinin Receptor	Neurological Disease
GR 83074 is a potent and selective NK-2 (Neurokinin *Receptor) antagonist with a pK_B* of 8.23. GR 83074 is inactive as an NK-3 antagonist and exhibits a 340-fold NK-2/NK-1 selectivity.

HY-14751A

Rolapitant hydrochloride SCH619734 hydrochloride	Neurokinin Receptor	Neurological Disease
Rolapitant (SCH619734) hydrochloride is a potent, selective, long-acting and orally active **neurokinin 1 (NK1) receptor antagonist with a K_i** of 0.66 nM. Rolapitant hydrochloride does not interact with CYP3A4. Rolapitant hydrochloride shows potent anti-emetic activity in a ferret emesis model.

HY-16436

Rolapitant hydrochloride hydrate SCH619734 hydrochloride hydrate	Neurokinin Receptor	Cancer Neurological Disease
Rolapitant hydrochloride hydrate (SCH619734 hydrochloride hydrate) is a potent, selective, long-acting and orally active **neurokinin 1 (NK1) receptor antagonist with a K_i** of 0.66 nM. Rolapitant hydrochloride hydrate does not interact with CYP3A4. Rolapitant hydrochloride hydrate shows potent anti-emetic activity in a ferret emesis model.

HY-14751

Rolapitant SCH619734	Neurokinin Receptor	Cancer Neurological Disease
Rolapitant (SCH619734) is a potent, selective, long-acting and orally active **neurokinin 1 (NK1) receptor antagonist with a K_i** of 0.66 nM. Rolapitant does not interact with CYP3A4. Rolapitant shows potent anti-emetic activity in a ferret emesis model.

HY-108482

CP-96,345	Neurokinin Receptor	Inflammation/Immunology Neurological Disease
CP-96,345 is a specific, highly potent, and orally active tachykinin and substance P receptor non-peptide inhibitor. CP-96,345 prevents the drop in blood pressure evoked by substance P and neurokinin A. CP-96,345 can be used for researching neurogenic inflammation.

HY-10053S1

Maropitant-13C,d3	Isotope-Labeled Compounds Neurokinin Receptor	Neurological Disease Endocrinology
Maropitant-¹³C,d₃ is the ¹³C- and deuterium labeled Maropitant. Maropitant is a selective and orally active neurokinin (NK1) receptor antagonist. Maropitant acts by blocking the binding of substance P within the emetic center and the chemoreceptor trigger zone (CRTZ). Maropitant is highly effective in preventing vomiting[1][2].

HY-107691

GR 159897	Neurokinin Receptor	Cancer Endocrinology Neurological Disease
GR 159897 is a highly potent, selective, competitive, brain-penetrated non-peptide **neurokinin 2 (NK₂) receptor** antagonist. GR 159897 has little or no affinity for NK₁ and NK₃ receptors. GR 159897 inhibits binding of [³H]GR100679 to human NK₂ (hNK₂)-CHO cells and rat colon membranes with pK_is of 9.51 and 10, respectively. Antagonizes bronchoconstriction. Anxiolytic-like and anti-tumor effects.

HY-14405A

Casopitant mesylate GW679769B	Neurokinin Receptor Cytochrome P450	Neurological Disease Cancer
Casopitant mesylate (GW679769B) is a potent, selective, brain permeable and orally active **neurokinin 1 (NK1) receptor antagonist. Casopitant mesylate is a second in the class of antiemetics that acts to antagonise the emetogenic effect of substance P. Casopitant mesylate is also a substrate and a weak-to-moderate inhibitor of CYP3A4**. Casopitant mesylate can be used for chemotherapy-induced nausea and vomiting (CINV) and postoperative nausea and vomiting (PONV).

HY-P3801

[Glp5,(Me)Phe8,Sar9] Substance P (5-11) DiMe-C7	Neurokinin Receptor	Metabolic Disease Neurological Disease Others
[Glp5,(Me)Phe8,Sar9] Substance P (5-11) (DiMe-C7) is a Substance P (HY-P0201) analogue that has approximately the same effects as Substance P (HY-P0201) on **neurokinin 1 receptor (NK1R**) in rat brain, but with a much longer duration of action. [Glp5,(Me)Phe8,Sar9] Substance P (5-11) selectively activates dopamine metabolism in the mesencephalon and midbrain cortex of the rat brain. [Glp5,(Me)Phe8,Sar9] Substance P (5-11) also increases motor activity and induces recovery of addictive agent-seeking behavior in rats.

Cat. No.	Product Name	Target	Research Area

HY-P3852

Neurokinin Receptor (393-407), rat SPR393-407	Neurokinin Receptor	Inflammation/Immunology Neurological Disease
Neurokinin Receptor (393-407), rat (SPR393–407) is a rat neurokinin 1 receptor (NK1R) fragment. NK1R is rapidly internalized by endocytosis and recycled to the plasma membrane when binding to substance P (SP). Neurokinin Receptor (393-407), rat can be used in the research of neurogenic inflammation.

HY-151413

MEN 10207	Neurokinin Receptor	Neurological Disease
MEN 10207 is a selective NK-2 tachykinin receptor (Neurokinin Receptor)?antagonist. MEN 10207 has pA₂ values of 5.2, 7.9 and 4.9 in three monoreceptor in vitro assays for NK-1, NK-2 and NK-3 tachykinin receptors, respectively.

HY-P1588

Scyliorhinin II	Neurokinin Receptor	Neurological Disease Endocrinology
Scyliorhinin II is a selective **neurokinin-3 receptor agonist, with a K_i** of 2.5 nM for neurokinin-3 receptor in rat cerebral cortex.

HY-P3862

[MePhe7]-Neurokinin B	Neurokinin Receptor	Endocrinology Neurological Disease
[MePhe7]-Neurokinin B is an **neurokinin NK-3 receptor (NK3R) agonist with an IC₅₀** value of 3 nM. [MePhe7]-Neurokinin B is a potential regulator of pulsatile gonadotropin-releasing hormone (GnRH) secretion via activation of the neurokinin-3 receptor (NK3R).

HY-P1031

[bAla8]-Neurokinin A(4-10)
MEN 10210
Neurokinin Receptor Endocrinology

[bAla8]-Neurokinin A(4-10) is a neurokinin 2 (NK2) receptor agonist.

HY-P3851

(β-Ala8)-Neurokinin A (4-10)	Neurokinin Receptor	Neurological Disease
(β-Ala8)-Neurokinin A (4-10), a neuropeptide, is a potent and selective NK-2 tachykinin receptor (Neurokinin *Receptor*) agonist.

HY-P0061

Vapreotide
RC160; BMY 41606
Neurokinin Receptor Cancer

Vapreotide is a neurokinin-1 (NK1) receptor antagonist, with an IC₅₀ of 330 nM.

HY-P1030

Hemokinin 1 (mouse)	Neurokinin Receptor	Endocrinology
Hemokinin 1 (mouse) is a selective agonist of **neurokinin-1 receptor, with K_i** of 0.175 nM and 560 nM for human NK1 receptor and human NK2 receptor, respectively.

HY-P0201

Substance P Neurokinin P	Neurokinin Receptor Endogenous Metabolite	Neurological Disease Endocrinology Cancer
Substance P (Neurokinin P) is a neuropeptide, acting as a neurotransmitter and as a neuromodulator in the CNS. The endogenous receptor for substance P is **neurokinin 1 receptor** (NK1-receptor, NK1R).

HY-P3850

(D-Pro2,D-Trp6,8,Nle10)-Neurokinin B	Neurokinin Receptor	Neurological Disease
(D-Pro2,D-Trp6,8,Nle10)-Neurokinin B is a competitive antagonist of Neurokinin B (Neurokinin *Receptor) with a pA2 of 5.5. (D-Pro2,D-Trp6,8,Nle10)-Neurokinin* B shows no influence on Substance P or Neurokinin A.

HY-P0061A

Vapreotide acetate RC-160 acetate; BMY-41606 acetate	Neurokinin Receptor	Cancer
Vapreotide acetate (RC-160 acetate; BMY-41606 acetate) is a **neurokinin-1 (NK1) receptor antagonist, with an IC₅₀** of 330 nM.

HY-P0201A

Substance P TFA Neurokinin P TFA	Neurokinin Receptor Endogenous Metabolite	Endocrinology Neurological Disease Cancer
Substance P TFA (Neurokinin P TFA) is a neuropeptide, acting as a neurotransmitter and as a neuromodulator in the CNS. The endogenous receptor for substance P is **neurokinin 1 receptor** (NK1-receptor, NK1R).

HY-P1276

Men 10376 Neurokinin-2 Receptor antagonist	Neurokinin Receptor	Endocrinology
Men 10376 is a selective tachykinin NK-2 receptor antagonist, with a K_i of 4.4 μM for rat small intestine NK-2 receptor.

HY-P0242

Neurokinin B	Neurokinin Receptor	Neurological Disease Endocrinology
Neurokinin B belongs to the tachykinin family of peptides. Neurokinin B binds a family of GPCRs-including neurokinin receptor 1 (NK1R), NK2R, and NK3R-to mediate their biological effect.

HY-P0242A

Neurokinin B TFA	Neurokinin Receptor	Neurological Disease Endocrinology
Neurokinin B TFA belongs to the tachykinin family of peptides. Neurokinin B binds a family of GPCRs-including neurokinin receptor 1 (NK1R), NK2R, and NK3R-to mediate their biological effect.

HY-P2546

Biotin-Substance P	Neurokinin Receptor	Neurological Disease
Biotin-Substance P is the biotin tagged Substance P. Substance P (Neurokinin P) is a neuropeptide, acting as a neurotransmitter and as a neuromodulator in the CNS. The endogenous receptor for substance P is neurokinin 1 receptor (NK1-receptor, NK1R).

HY-P0236

Neurokinin A(4-10)
Neurokinin Receptor Neurological Disease Endocrinology

Neurokinin A (4-10) is a tachykinin NK₂ receptor agonist.

HY-P0197

Neurokinin A Substance K; Neurokinin α; Neuromedin L	Neurokinin Receptor	Neurological Disease Endocrinology
Neurokinin A (Substance K), a peptide neurotransmitter of the tachykinin family, acts via the NK-2 receptor. Neurokinin A acts as a major mediator in human airway and gastrointestinal tissues.

HY-P0197A

Neurokinin A TFA Substance K TFA; Neurokinin α TFA; Neuromedin L TFA	Neurokinin Receptor	Endocrinology Neurological Disease
Neurokinin A TFA (Substance K TFA), a peptide neurotransmitter of the tachykinin family, acts via the NK-2 receptor. Neurokinin A acts as a major mediator in human airway and gastrointestinal tissues.

HY-105436

FR 113680
Neurokinin Receptor Neurological Disease

FR 113680 is a tripeptide substance P antagonist that interacts selectively with the NK₁ neurokinin receptor.

HY-P3849

[Lys5,MeLeu9,Nle10]Neurokinin A(4-10) LMN-NKA	Neurokinin Receptor	Neurological Disease
[Lys5,MeLeu9,Nle10]Neurokinin A(4-10) (LMN-NKA), an analogue of Neurokinin A, is a selective and potent NK2R agonist. [Lys5,MeLeu9,Nle10]Neurokinin A(4-10) has prokinetic activity. [Lys5,MeLeu9,Nle10]Neurokinin A(4-10) can be used to study the roles of the NK-2 receptor in smooth muscle contraction in numerous tissues.

HY-P0236A

Neurokinin A(4-10) TFA
Neurokinin Receptor Neurological Disease Endocrinology

Neurokinin A (4-10) TFA is a tachykinin NK₂ receptor agonist.

HY-P1276A

Men 10376 TFA Neurokinin-2 Receptor antagonist TFA	Neurokinin Receptor	Endocrinology
Men 10376 TFA is a selective tachykinin NK-2 receptor antagonist, with a K_i of 4.4 μM for rat small intestine NK-2 receptor.

HY-P3861

Biotin-NeurokininA	Neurokinin Receptor	Neurological Disease
Biotin-NeurokininA is a biotinylated NeurokininA (HY-P0197). Neurokinin A (Substance K), a peptide neurotransmitter of the tachykinin family, acts via the NK-2 receptor. Neurokinin A acts as a major mediator in human airway and gastrointestinal tissues.

HY-P1738

[Sar9] Substance P
Neurokinin Receptor Neurological Disease Endocrinology

[Sar9] Substance P is a potent and selective neurokinin (NK)-1 receptor agonist.

HY-P3069

γ-Neuropeptide (rabbit)	Neurokinin Receptor	Endocrinology Neurological Disease
γ-Neuropeptide (rabbit) can be isolated from rabbit intestine. γ-Neuropeptide is an endogenous neurokinin peptide that acts as a **neurokinin 2 (NK2) receptor** agonist. γ-Neuropeptide mediates hypothalamic-pituitary-adrenal (HPA) axis, as well as reproductive hormone release.

HY-P1722

Spantide II	Neurokinin Receptor	Inflammation/Immunology
Spantide II, an undecapeptide substance P (SP) analog, is a potent neurokinin-1 receptor (NK-1R) antagonist. Spantide II binds with NK-1R and blocks proinflammatory activities associated with SP. Spantide II can be used in the research of inflammatory skin disorders, such as psoriasis and contact dermatitis.

HY-P1198

Hemokinin 1, human	Neurokinin Receptor	Neurological Disease
Hemokinin 1, human is a selective tachykinin neurokinin 1 (NK1) receptor full agonist. Hemokinin 1, human is a full agonist at NK2 and NK3 receptor. Hemokinin 1, human can produces an opioid-independent analgesia.

HY-P3802

[D-Trp2,7,9] Substance P	Neurokinin Receptor	Neurological Disease
[D-Trp2,7,9] Substance P is a tachykinin (Neurokinin *Receptor) antagonist with K_i* values of 1 μM, 1.3 μM, and ~9 μM for NK-1, NK-2,and NK-3 receptor, respectively.

HY-P1192

GR-73632	Neurokinin Receptor	Neurological Disease Endocrinology
GR-73632 is a novel tachykinin neurokinin 1 (NK-1) receptor agonist. GR-73632 acts directly on the peripheral terminals of primary sensory neurons through NK1 receptor which convey itch signals.

HY-P3598

Substance P(1-4)	Peptides	Cancer
Substance P(1-4) is a potent neurokinin receptors (NK-R) antagonist. Substance P(1-4) has regulation of normal hematopoiesis and inhibits endogenous erythroid colony (EEC) formation.

HY-P1198A

Hemokinin 1, human TFA	Neurokinin Receptor	Neurological Disease
Hemokinin 1, human TFA is a selective tachykinin neurokinin 1 (NK1) receptor full agonist. Hemokinin 1, human TFA is a full agonist at NK2 and NK3 receptor. Hemokinin 1, human TFA can produces an opioid-independent analgesia.

HY-P3854

GR 83074	Neurokinin Receptor	Neurological Disease
GR 83074 is a potent and selective NK-2 (Neurokinin *Receptor) antagonist with a pK_B* of 8.23. GR 83074 is inactive as an NK-3 antagonist and exhibits a 340-fold NK-2/NK-1 selectivity.

HY-P3801

[Glp5,(Me)Phe8,Sar9] Substance P (5-11) DiMe-C7	Neurokinin Receptor	Metabolic Disease Neurological Disease Others
[Glp5,(Me)Phe8,Sar9] Substance P (5-11) (DiMe-C7) is a Substance P (HY-P0201) analogue that has approximately the same effects as Substance P (HY-P0201) on **neurokinin 1 receptor (NK1R**) in rat brain, but with a much longer duration of action. [Glp5,(Me)Phe8,Sar9] Substance P (5-11) selectively activates dopamine metabolism in the mesencephalon and midbrain cortex of the rat brain. [Glp5,(Me)Phe8,Sar9] Substance P (5-11) also increases motor activity and induces recovery of addictive agent-seeking behavior in rats.

Cat. No.	Product Name	Target	Research Area

HY-108482

CP-96,345	Neurokinin Receptor	Inflammation/Immunology Neurological Disease
CP-96,345 is a specific, highly potent, and orally active tachykinin and substance P receptor non-peptide inhibitor. CP-96,345 prevents the drop in blood pressure evoked by substance P and neurokinin A. CP-96,345 can be used for researching neurogenic inflammation.

Cat. No.	Product Name	Target	Category

HY-118463

Benzomalvin A	Neurokinin Receptor	Alkaloids Quinoline Alkaloids Source classification Microorganisms
Benzomalvin A is a potent antagonist of **neurokinin receptor** isolated from Penicillium sp. Benzomalvin A shows inhibitory activity against substance P with K_i values of 12, 42 and 43 μM at the guinea pig, rat and human neurokinin NK1 receptors, respectively.

HY-P0201

Substance P Neurokinin P	Neurokinin Receptor Endogenous Metabolite	Structural Classification Natural Products Endogenous metabolite Source classification Neurological Disease Disease Research Fields Classification of Application Fields Endocrinology
Substance P (Neurokinin P) is a neuropeptide, acting as a neurotransmitter and as a neuromodulator in the CNS. The endogenous receptor for substance P is **neurokinin 1 receptor** (NK1-receptor, NK1R).

HY-P0255

Physalaemin	Neurokinin Receptor	Phenols Ketones, Aldehydes, Acids Classification of Application Fields Disease Research Fields Endocrinology Neurological Disease Source classification Animals
Physalaemin, a non-mammalian tachykinin, binds selectively to *neurokinin-1* (NK1) *receptor* with high affinity.

HY-119552

Acetylaszonalenin LL-S490β	Endogenous Metabolite Neurokinin Receptor	Alkaloids Indole Alkaloids Source classification Microorganisms
Acetylaszonalenin, a prenylated indole derivative, is a fungal metabolite.Acetylaszonalenin is a potent neurokinin-1 (NK1) receptor antagonist. Acetylaszonalenin shows inhibition of [³H]-SP binding to human astrocytoma cells with a K_i of 170 μM.

Cat. No.	Product Name

HY-16346S

Netupitant-d6

Netupitant-d₆ is the deuterium labeled Netupitant (CID-6451149), which is a highly potent and selective, orally active neurokinin-1 (NK1) receptor antagonist[1].

HY-14407AS

Fosaprepitant-d4 dimeglumine
Fosaprepitant-d₄ (dimeglumine) is deuterium labeled Fosaprepitant (dimeglumine). Fosaprepitant dimeglumine (MK-0517) is a proagent of Aprepitant (HY-10052). Fosaprepitant dimeglumine is a neurokinin-1 receptor antagonist, which is development for the prevention of chemotherapy-induced nausea and vomiting (CINV)[1].

HY-10053S1

Maropitant-13C,d3
Maropitant-¹³C,d₃ is the ¹³C- and deuterium labeled Maropitant. Maropitant is a selective and orally active neurokinin (NK1) receptor antagonist. Maropitant acts by blocking the binding of substance P within the emetic center and the chemoreceptor trigger zone (CRTZ). Maropitant is highly effective in preventing vomiting[1][2].

Neurokinin Receptor

Inhibitors & Agonists

Peptides

Inhibitory Antibodies

NaturalProducts

Isotope-Labeled Compounds

Natural
Products