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Neuropeptide Y Receptor

" in MCE Product Catalog:

By Targets:	Neuropeptide Y Receptor (43) Mas-related G-protein-coupled Receptor (MRGPR) (1) Neurokinin Receptor (1)
By Research Areas:	Cancer (1) Cardiovascular Disease (3) Endocrinology (13) Metabolic Disease (12) Neurological Disease (32)

Inhibitors & Agonists

Fluorescent Dye

Peptides

Recombinant Proteins

Targets Recommended: Neuropeptide Y Receptor

Cat. No.	Product Name	Target	Research Areas

HY-144603

Neuropeptide Y Y1 receptor antagonist 1	Neuropeptide Y Receptor	Neurological Disease
Neuropeptide Y Y1 receptor antagonist 1 (compound 39), a fluorescent probe, is a potent antagonist of neuropeptide Y Y 1 receptor (Y 1R), with a K_i of 0.19 nM. Storage: protect from light.

HY-148179

Neuropeptide Y5 receptor ligand-1	Neuropeptide Y Receptor	Neurological Disease
Neuropeptide Y5 receptor ligand-1 (compound 54), a carbazole derivative, is a potent **neuropeptide Y5 (NPY-5) receptor** antagonist.

HY-P3676

Neuropeptide Y (3-36) (porcine)	Neuropeptide Y Receptor	Neurological Disease
Neuropeptide Y (3-36) (porcine) is an agonist of neuropeptide Y (NPY) receptor subtype Y2, and stimulates feeding in rats. Neuropeptide Y (3-36) (porcine) is a highly Y2 selective ligand compared with nselective Y1/Y2 receptor ligand, Neuropeptide Y 1-36.

HY-145837

Y1R probe-1	Neuropeptide Y Receptor	Cancer
Y1R probe-1 (Compound 39) is a high-affinity fluorescence probe for the Neuropeptide Y Y1 Receptor. Y1R probe-1 has the potential for the research of cancer disease.

HY-P3678

Neuropeptide Y (18-36) (porcine)	Neuropeptide Y Receptor	Neurological Disease Cardiovascular Disease
Neuropeptide Y (18-36) (porcine) is a competitive neuropeptide Y (NPY) cardiac receptor antagonist. Neuropeptide Y (18-36) (porcine) inhibits the binding of I-NPY to cardiac ventricular membranes in a concentration-dependent manner with an IC₅₀ value of 158 nM and an K_i value of 140 nM. Neuropeptide Y (18-36) (porcine) can be used for the research of congestive heart failure.

HY-P1818

Neuropeptide Y (22-36)	Neuropeptide Y Receptor	Neurological Disease Endocrinology
Neuropeptide Y (22-36), a 15 amino acid peptide, is a fragment of Neuropeptide Y. Neuropeptide Y (22-36) acts on Y₂ receptor and retains subnanomolar affinity for the Y₂ receptor.

HY-P1322

[D-Trp34]-Neuropeptide Y	Neuropeptide Y Receptor	Neurological Disease
[D-Trp34]-Neuropeptide Y is a potent and selective **neuropeptide Y (NPY) Y₅ receptor** agonist. [D-Trp34]-Neuropeptide Y is a significantly less potent agonist at the NPY Y₁, Y₂, Y₄, and y₆ receptors. [D-Trp34]-Neuropeptide Y markedly increases food intake in rats.

HY-P1322A

[D-Trp34]-Neuropeptide Y TFA	Neuropeptide Y Receptor	Neurological Disease
[D-Trp34]-Neuropeptide Y TFA is a potent and selective **neuropeptide Y (NPY) Y₅ receptor** agonist. [D-Trp34]-Neuropeptide Y TFA is a significantly less potent agonist at the NPY Y₁, Y₂, Y₄, and y₆ receptors. [D-Trp34]-Neuropeptide Y TFA markedly increases food intake in rats.

HY-P1321

GR231118 1229U91; GW1229	Neuropeptide Y Receptor	Neurological Disease
GR231118, an analogue of the C-terminus of neuropeptide Y, is a potent , competitive and relative seletive antagonist at human **neuropeptide Y Y receptor with a pK_i** of 10.4. GR231118 a potent agonist at the human neuropeptide Y Y4 receptor (pEC₅₀=8.6; pK_i=9.6) and a weak agonist at the human and rat neuropeptide YY2 and Y5 receptors. GR231118 also has high affinity for the mouse neuropeptide Y Y6 receptor (pK_i= 8.8).

HY-P3677

Neuropeptide Y (2-36) (porcine)	Neuropeptide Y Receptor	Neurological Disease
Neuropeptide Y (2-36) (porcine) is a porcine-derived neuropeptide with 97.14% homology to rat/human origin. Neuropeptide Y (2-36) (porcine) is also a rat **neuropeptide receptor agonist, with EC₅₀** values of 1.2, 1.6 and 3.4 nM for receptor of Y5, Y2 and Y1 respectively. Neuropeptide Y (2-36) (porcine) can be used in studies related to obesity and eating disorders.

HY-P2543

Neuropeptide Y (3-36) (human, rat)	Neuropeptide Y Receptor	Metabolic Disease
Neuropeptide Y (3-36) (human, rat), a neuropeptide Y (NPY) metabolite formed from dipeptidyl peptidase-4 (DPP4), is a selective Y2 receptor agonist. Neuropeptide Y (3-36) (human, rat) is a NPY metabolite formed from dipeptidyl peptidase-4 (DPP4). Neuropeptide Y (3-36) (human, rat) decreases release of norepinephrine via the Y2 receptor.

HY-P1480

Neuropeptide Y (13-36), amide, human Neuropeptide Y (13-36), human	Neuropeptide Y Receptor	Neurological Disease Endocrinology
Neuropeptide Y (13-36), amide, human is a selective neuropeptide Y₂ receptor agonist.

HY-P1323

[Leu31,Pro34]-Neuropeptide Y(human,rat)	Neuropeptide Y Receptor	Neurological Disease Cardiovascular Disease
[Leu31,Pro34]-Neuropeptide Y(human,rat) is a specific **neuropeptide Y Y₁ receptor** agonist. [Leu31,Pro34]-Neuropeptide Y(human,rat) slao activates Y₄, Y₅. [Leu31,Pro34]-Neuropeptide Y(human,rat) can increase blood pressure in anesthetized rats and increases food intake.

HY-P1321A

GR231118 TFA 1229U91 TFA; GW1229 TFA	Neuropeptide Y Receptor	Neurological Disease
GR231118 TFA, an analogue of the C-terminus of neuropeptide Y, is a potent , competitive and relative seletive antagonist at human **neuropeptide YY receptor with a pK_i** of 10.4. GR231118 a potent agonist at the human neuropeptide YY4 receptor (pEC₅₀=8.6; pK_i=9.6) and a weak agonist at the human and rat neuropeptide Y Y2 and Y5 receptors. GR231118 also has high affinity for the mouse neuropeptide YY6 receptor (pK_i= 8.8).

HY-P1323A

[Leu31,Pro34]-Neuropeptide Y(human,rat) TFA	Neuropeptide Y Receptor	Neurological Disease Cardiovascular Disease
[Leu31,Pro34]-Neuropeptide Y(human,rat) TFA is a specific **neuropeptide Y Y₁ receptor** agonist. [Leu31,Pro34]-Neuropeptide Y(human,rat) TFA slao activates Y₄, Y₅. [Leu31,Pro34]-Neuropeptide Y(human,rat) TFA can increase blood pressure in anesthetized rats and increases food intake.

HY-P3876

(Pro34)-Peptide YY (human)	Neuropeptide Y Receptor	Neurological Disease
(Pro34)-Peptide YY (human) is a highly Y₁-selective full agonist of Peptide YY (HY-P1514)/neuropeptide Y receptors.

HY-P0208

[Leu31,Pro34]-Neuropeptide Y (porcine)	Neuropeptide Y Receptor	Neurological Disease
[Leu31,Pro34]- Neuropeptide Y (porcine), a Neuropeptide Y (NPY) analog, is a selective NPY Y1 receptor agonist. [Leu31,Pro34]- Neuropeptide Y (porcine) exhibits anxiolytic effects.

HY-101704

Y1 receptor antagonist 1
H 409-22 isomer
Neurokinin Receptor Neurological Disease Endocrinology

Y1 receptor antagonist 1 (H 409-22 isomer) is a neuropeptide Y1 receptor antagonist.
HY-14423

Velneperit
S2367
Neuropeptide Y Receptor Metabolic Disease Endocrinology

Velneperit (S-2367) is a novel neuropeptide Y (NPY) Y5 receptor antagonist.
HY-U00335

FR252384
Neuropeptide Y Receptor Endocrinology

FR252384 is a neuropeptide Y-Y5 receptor antagonist, with an IC₅₀ of 2.3 nM.

Y1 receptor antagonist 1 H 409-22 isomer	Neurokinin Receptor	Neurological Disease Endocrinology
Y1 receptor antagonist 1 (H 409-22 isomer) is a **neuropeptide Y1 receptor** antagonist.

Velneperit S2367	Neuropeptide Y Receptor	Metabolic Disease Endocrinology
Velneperit (S-2367) is a novel neuropeptide Y (NPY) Y5 receptor antagonist.

FR252384	Neuropeptide Y Receptor	Endocrinology
FR252384 is a **neuropeptide Y-Y5 receptor antagonist, with an IC₅₀** of 2.3 nM.

HY-P0198B

[D-Arg25]-Neuropeptide Y (human)	Neuropeptide Y Receptor	Metabolic Disease Neurological Disease
[D-Arg25]-Neuropeptide Y (human) ([D-Arg25] NPY) is a Y₁ receptor selective agonist. Neuropeptide Y (human) is involved in Alzheimer's disease (AD) and protects rat cortical neurons against β-Amyloid toxicity.

HY-107723

CGP71683 hydrochloride CGP71683A	Neuropeptide Y Receptor	Neurological Disease Endocrinology
CGP71683 hydrochloride is a competitive **neuropeptide Y5 receptor antagonist with a K_i** of 1.3 nM, and shows no obvious activity at Y1 receptor (K_i, >4000 nM) and Y2 receptor (K_i, 200 nM) in cell membranes.

HY-107733

NTNCB hydrochloride	Neuropeptide Y Receptor	Neurological Disease
NTNCB (Compound 11) hydrochloride is a potent and selective **neuropeptide Y Y5 (NPY Y5) receptor antagonist with a K_i** of 8 nM against human Y5.

HY-107728

S 25585	Neuropeptide Y Receptor	Metabolic Disease
S 25585 is a potent and selective neuropeptide Y (NPY) Y5 receptor antagonist. S 25585 reduces food intake but not through blockade of the NPY Y5 receptor.

HY-P0199

Pancreatic Polypeptide, human Human pancreatic polypeptide	Neuropeptide Y Receptor	Metabolic Disease Endocrinology
Pancreatic Polypeptide, human is a C-terminally amidated 36 amino acid peptide, which acts as a neuropeptide Y (NPY) Y4/Y5 receptor agonist.

HY-107726A

BIBP3226	Neuropeptide Y Receptor	Neurological Disease
BIBP3226 is a potent and selective neuropeptide Y Y1 (NPY Y1) and neuropeptide FF (NPFF) receptor antagonist, with K_is of 1.1, 79, and 108 nM for rNPY Y1, hNPFF2, and rNPFF, respectively. BIBP3226 displays anxiogenic-like effect.

HY-107726

BIBP3226 TFA	Neuropeptide Y Receptor	Neurological Disease
BIBP3226 TFA is a potent and selective neuropeptide Y Y1 (NPY Y1) and neuropeptide FF (NPFF) receptor antagonist, with K_is of 1.1, 79, and 108 nM for rNPY Y1, hNPFF2, and rNPFF, respectively. BIBP3226 TFA displays anxiogenic-like effect.

HY-101986

BIIE-0246 AR-H 053591	Neuropeptide Y Receptor	Metabolic Disease Endocrinology
BIIE-0246 is a potent and highly selective *non-peptide* neuropeptide Y (NPY) Y₂** receptor antagonist, with an IC₅₀ of 15 nM.

HY-107735

CYM 9484
Neuropeptide Y Receptor Neurological Disease

CYM 9484 is a selective and highly potent neuropeptide Y (NPY) Y2 receptor antagonist with an IC₅₀ value of 19 nM.
HY-107731

SF 11
Neuropeptide Y Receptor Neurological Disease

SF 11 is a potent and brain penetrant neuropeptide Y Y2 receptor antagonist (IC₅₀=199 nM). Antidepressant-like activity.

CYM 9484	Neuropeptide Y Receptor	Neurological Disease
CYM 9484 is a selective and highly potent **neuropeptide Y (NPY) Y2 receptor antagonist with an IC₅₀** value of 19 nM.

SF 11	Neuropeptide Y Receptor	Neurological Disease
SF 11 is a potent and brain penetrant **neuropeptide Y Y2 receptor antagonist (IC₅₀**=199 nM). Antidepressant-like activity.

HY-107732

JNJ-5207787	Neuropeptide Y Receptor	Neurological Disease
JNJ-5207787 is a nonpeptidic, selective and penetrate the blood-brain barrier **neuropeptide Y Y₂ receptor (Y₂)** antagonist. JNJ-5207787 inhibits the binding of peptide YY (PYY) with pIC₅₀s of 7.0 and 7.1 for human Y₂ receptor and rat Y₂ receptor, respectively. JNJ-5207787 is >100-fold selective versus human Y₁, Y₄, and Y₅ receptors.

HY-15411

MK-0557
Neuropeptide Y Receptor Metabolic Disease Endocrinology

MK-0557 is a highly selective, orally available neuropeptide Y5 receptor antagonist with a K_i of 1.6 nM.

MK-0557	Neuropeptide Y Receptor	Metabolic Disease Endocrinology
MK-0557 is a highly selective, orally available neuropeptide Y5 receptor antagonist with a K_i of 1.6 nM.

HY-107725

BIBO3304 TFA	Neuropeptide Y Receptor	Metabolic Disease
BIBO3304 TFA is a potent, orally active, and selective **neuropeptide Y (NPY) Y1 receptor** antagonist, with subnanomolar affinity for both the human and the rat Y1 receptor (IC₅₀=0.38 and 0.72 nM, respectively).

HY-14450

JNJ-31020028	Neuropeptide Y Receptor	Neurological Disease Endocrinology
JNJ-31020028 is a selective and brain penetrant antagonist of **neuropeptide Y Y2 receptor with pIC₅₀** values of 8.07 and 8.22 for human and rat Y2 receptor, respectively. JNJ-31020028 can be used for the research of nervous disease.

HY-P3843

Neuropeptide AF (cattle)	Mas-related G-protein-coupled Receptor (MRGPR) Neuropeptide Y Receptor	Neurological Disease
Neuropeptide AF (cattle), an amidated octadecapeptide, is RFamide neuropeptide. Neuropeptide AF (cattle) acts as a ligand of *Mas-related gene receptor* A4 (MrgprA4) (Mas-related G-protein-coupled Receptor (MRGPR)) (EC₅₀ of ~60 nM) and MrgprC11 (EC₅₀** of ~300 nM). Neuropeptide AF (cattle) also activate to the G protein-coupled receptors NPFF1 (Neuropeptide Y Receptor) (EC₅₀ of ~25-325 nM) and NPFF2 (EC₅₀ of ~1-5 nM). Neuropeptide AF (cattle) shows anti-opiate and related pain modulation effects.

HY-107479

(R)-JNJ-31020028	Neuropeptide Y Receptor	Neurological Disease
(R)-JNJ-31020028 is a high affinity, selective brain penetrant **neuropeptide Y Y2 receptor antagonist, with pIC₅₀** values of 8.07, 8.22 and 8.21 for human, rat, and mouse Y2 receptor, respectively. (R)-JNJ-31020028 shows >100-fold selective versus human Y1, Y4, and Y5 receptors. (R)-JNJ-31020028 has antidepressant like effects.

HY-P10000

Peptide YY (PYY) (3-36), Human	Neuropeptide Y Receptor	Metabolic Disease
Peptide YY (PYY) (3-36), Human is an endogenous appetite suppressing peptide. Peptide YY (PYY) (3-36), Human, a neuropeptide Y (NPY) Y2 receptor agonist, is a powerful inhibitor of intestinal secretion.

HY-107729

Lu AA33810	Neuropeptide Y Receptor	Neurological Disease
Lu AA33810 is a potent and selective antagonist of **neuropeptide Y5 receptor with a K_i** of 1.5 nM for the human receptor. Lu AA33810 exhibts antianxiolytic-like and antidepressant-like effects.

HY-P1514

Peptide YY (PYY), human	Neuropeptide Y Receptor	Metabolic Disease Neurological Disease Endocrinology
Peptide YY (PYY) is a gut hormone that regulates appetite and inhibits pancreatic secretion. Peptide YY (PYY) can mediate its effects through the **Neuropeptide Y receptors**.

HY-107734

L 152804	Neuropeptide Y Receptor	Metabolic Disease Endocrinology
L 152804 is an orally active and selective neuropeptide Y Y5 receptor (NPY5-R) antagonist, with a K_i of 26 nM for hY5. L 152804 causes weight loss in diet-induced obese mice by modulating food intake and energy expenditure.

HY-120619

BMS-193885	Neuropeptide Y Receptor	Neurological Disease Endocrinology
BMS-193885 is a potent, selective, competitive, and brain penetrant **neuropeptide Y₁ receptor antagonist with a K_i of 3.3 nM, and has an IC₅₀** of 5.9 nM for hY₁, which displays > 100, > 160, > 160 and > 160-fold selectivity over α₁, hY₂, hY₄ and hY₅ receptors, respectively .

HY-P1324A

[cPP1-7,NPY19-23,Ala31,Aib32,Gln34]-hPancreatic polypeptide TFA	Neuropeptide Y Receptor	Neurological Disease
[cPP1-7,NPY19-23,Ala31,Aib32,Gln34]-hPancreatic Polypeptide is a potent and selective neuropeptide Y Y₅ receptor agonist with an IC₅₀ of 0.24 nM for binding to the hY₅ receptor. [cPP1-7,NPY19-23,Ala31,Aib32,Gln34]-hPancreatic Polypeptide induces a high amount of food intake.

HY-P1324

[cPP1-7,NPY19-23,Ala31,Aib32,Gln34]-hPancreatic Polypeptide	Neuropeptide Y Receptor	Neurological Disease
[cPP1-7,NPY19-23,Ala31,Aib32,Gln34]-hPancreatic Polypeptide is a potent and selective neuropeptide Y Y₅ receptor agonist with an IC₅₀ of 0.24 nM for binding to the hY₅ receptor. [cPP1-7,NPY19-23,Ala31,Aib32,Gln34]-hPancreatic Polypeptide induces a high amount of food intake.

HY-101986A

BIIE-0246 hydrochloride AR-H 053591 hydrochloride	Neuropeptide Y Receptor	Metabolic Disease
BIIE-0246 hydrochloride (AR-H 053591 hydrochloride) is a potent and selective *NPY2R (neuropeptide* Y receptor 2) antagonist with an IC₅₀** value of 15 nM for rat [¹²⁵I]PYY_3-36. BIIE-0246 hydrochloride decreases the expression of p-AKT S473, P-p44/42 MAPK under the NPY-stimulated. BIIE-0246 hydrochloride reduces albuminuria in ADR nephropathy.

Cat. No.	Product Name	Type

HY-144603

Neuropeptide Y Y1 receptor antagonist 1	Fluorescent Dyes/Probes
Neuropeptide Y Y1 receptor antagonist 1 (compound 39), a fluorescent probe, is a potent antagonist of neuropeptide Y Y 1 receptor (Y 1R), with a K_i of 0.19 nM. Storage: protect from light.

Cat. No.	Product Name	Target	Research Area

HY-P3676

Neuropeptide Y (3-36) (porcine)	Neuropeptide Y Receptor	Neurological Disease
Neuropeptide Y (3-36) (porcine) is an agonist of neuropeptide Y (NPY) receptor subtype Y2, and stimulates feeding in rats. Neuropeptide Y (3-36) (porcine) is a highly Y2 selective ligand compared with nselective Y1/Y2 receptor ligand, Neuropeptide Y 1-36.

HY-P3678

Neuropeptide Y (18-36) (porcine)	Neuropeptide Y Receptor	Neurological Disease Cardiovascular Disease
Neuropeptide Y (18-36) (porcine) is a competitive neuropeptide Y (NPY) cardiac receptor antagonist. Neuropeptide Y (18-36) (porcine) inhibits the binding of I-NPY to cardiac ventricular membranes in a concentration-dependent manner with an IC₅₀ value of 158 nM and an K_i value of 140 nM. Neuropeptide Y (18-36) (porcine) can be used for the research of congestive heart failure.

HY-P1818

Neuropeptide Y (22-36)	Neuropeptide Y Receptor	Neurological Disease Endocrinology
Neuropeptide Y (22-36), a 15 amino acid peptide, is a fragment of Neuropeptide Y. Neuropeptide Y (22-36) acts on Y₂ receptor and retains subnanomolar affinity for the Y₂ receptor.

HY-P1322

[D-Trp34]-Neuropeptide Y	Neuropeptide Y Receptor	Neurological Disease
[D-Trp34]-Neuropeptide Y is a potent and selective **neuropeptide Y (NPY) Y₅ receptor** agonist. [D-Trp34]-Neuropeptide Y is a significantly less potent agonist at the NPY Y₁, Y₂, Y₄, and y₆ receptors. [D-Trp34]-Neuropeptide Y markedly increases food intake in rats.

HY-P1322A

[D-Trp34]-Neuropeptide Y TFA	Neuropeptide Y Receptor	Neurological Disease
[D-Trp34]-Neuropeptide Y TFA is a potent and selective **neuropeptide Y (NPY) Y₅ receptor** agonist. [D-Trp34]-Neuropeptide Y TFA is a significantly less potent agonist at the NPY Y₁, Y₂, Y₄, and y₆ receptors. [D-Trp34]-Neuropeptide Y TFA markedly increases food intake in rats.

HY-P1321

GR231118 1229U91; GW1229	Neuropeptide Y Receptor	Neurological Disease
GR231118, an analogue of the C-terminus of neuropeptide Y, is a potent , competitive and relative seletive antagonist at human **neuropeptide Y Y receptor with a pK_i** of 10.4. GR231118 a potent agonist at the human neuropeptide Y Y4 receptor (pEC₅₀=8.6; pK_i=9.6) and a weak agonist at the human and rat neuropeptide YY2 and Y5 receptors. GR231118 also has high affinity for the mouse neuropeptide Y Y6 receptor (pK_i= 8.8).

HY-P3677

Neuropeptide Y (2-36) (porcine)	Neuropeptide Y Receptor	Neurological Disease
Neuropeptide Y (2-36) (porcine) is a porcine-derived neuropeptide with 97.14% homology to rat/human origin. Neuropeptide Y (2-36) (porcine) is also a rat **neuropeptide receptor agonist, with EC₅₀** values of 1.2, 1.6 and 3.4 nM for receptor of Y5, Y2 and Y1 respectively. Neuropeptide Y (2-36) (porcine) can be used in studies related to obesity and eating disorders.

HY-P2543

Neuropeptide Y (3-36) (human, rat)	Neuropeptide Y Receptor	Metabolic Disease
Neuropeptide Y (3-36) (human, rat), a neuropeptide Y (NPY) metabolite formed from dipeptidyl peptidase-4 (DPP4), is a selective Y2 receptor agonist. Neuropeptide Y (3-36) (human, rat) is a NPY metabolite formed from dipeptidyl peptidase-4 (DPP4). Neuropeptide Y (3-36) (human, rat) decreases release of norepinephrine via the Y2 receptor.

HY-P1480

Neuropeptide Y (13-36), amide, human Neuropeptide Y (13-36), human	Neuropeptide Y Receptor	Neurological Disease Endocrinology
Neuropeptide Y (13-36), amide, human is a selective neuropeptide Y₂ receptor agonist.

HY-P1323

[Leu31,Pro34]-Neuropeptide Y(human,rat)	Neuropeptide Y Receptor	Neurological Disease Cardiovascular Disease
[Leu31,Pro34]-Neuropeptide Y(human,rat) is a specific **neuropeptide Y Y₁ receptor** agonist. [Leu31,Pro34]-Neuropeptide Y(human,rat) slao activates Y₄, Y₅. [Leu31,Pro34]-Neuropeptide Y(human,rat) can increase blood pressure in anesthetized rats and increases food intake.

HY-P1321A

GR231118 TFA 1229U91 TFA; GW1229 TFA	Neuropeptide Y Receptor	Neurological Disease
GR231118 TFA, an analogue of the C-terminus of neuropeptide Y, is a potent , competitive and relative seletive antagonist at human **neuropeptide YY receptor with a pK_i** of 10.4. GR231118 a potent agonist at the human neuropeptide YY4 receptor (pEC₅₀=8.6; pK_i=9.6) and a weak agonist at the human and rat neuropeptide Y Y2 and Y5 receptors. GR231118 also has high affinity for the mouse neuropeptide YY6 receptor (pK_i= 8.8).

HY-P1323A

[Leu31,Pro34]-Neuropeptide Y(human,rat) TFA	Neuropeptide Y Receptor	Neurological Disease Cardiovascular Disease
[Leu31,Pro34]-Neuropeptide Y(human,rat) TFA is a specific **neuropeptide Y Y₁ receptor** agonist. [Leu31,Pro34]-Neuropeptide Y(human,rat) TFA slao activates Y₄, Y₅. [Leu31,Pro34]-Neuropeptide Y(human,rat) TFA can increase blood pressure in anesthetized rats and increases food intake.

HY-P3876

(Pro34)-Peptide YY (human)	Neuropeptide Y Receptor	Neurological Disease
(Pro34)-Peptide YY (human) is a highly Y₁-selective full agonist of Peptide YY (HY-P1514)/neuropeptide Y receptors.

HY-P0208

[Leu31,Pro34]-Neuropeptide Y (porcine)	Neuropeptide Y Receptor	Neurological Disease
[Leu31,Pro34]- Neuropeptide Y (porcine), a Neuropeptide Y (NPY) analog, is a selective NPY Y1 receptor agonist. [Leu31,Pro34]- Neuropeptide Y (porcine) exhibits anxiolytic effects.

HY-P0198B

[D-Arg25]-Neuropeptide Y (human)	Neuropeptide Y Receptor	Metabolic Disease Neurological Disease
[D-Arg25]-Neuropeptide Y (human) ([D-Arg25] NPY) is a Y₁ receptor selective agonist. Neuropeptide Y (human) is involved in Alzheimer's disease (AD) and protects rat cortical neurons against β-Amyloid toxicity.

HY-P0199

Pancreatic Polypeptide, human Human pancreatic polypeptide	Neuropeptide Y Receptor	Metabolic Disease Endocrinology
Pancreatic Polypeptide, human is a C-terminally amidated 36 amino acid peptide, which acts as a neuropeptide Y (NPY) Y4/Y5 receptor agonist.

HY-P3843

Neuropeptide AF (cattle)	Mas-related G-protein-coupled Receptor (MRGPR) Neuropeptide Y Receptor	Neurological Disease
Neuropeptide AF (cattle), an amidated octadecapeptide, is RFamide neuropeptide. Neuropeptide AF (cattle) acts as a ligand of *Mas-related gene receptor* A4 (MrgprA4) (Mas-related G-protein-coupled Receptor (MRGPR)) (EC₅₀ of ~60 nM) and MrgprC11 (EC₅₀** of ~300 nM). Neuropeptide AF (cattle) also activate to the G protein-coupled receptors NPFF1 (Neuropeptide Y Receptor) (EC₅₀ of ~25-325 nM) and NPFF2 (EC₅₀ of ~1-5 nM). Neuropeptide AF (cattle) shows anti-opiate and related pain modulation effects.

HY-P10000

Peptide YY (PYY) (3-36), Human	Neuropeptide Y Receptor	Metabolic Disease
Peptide YY (PYY) (3-36), Human is an endogenous appetite suppressing peptide. Peptide YY (PYY) (3-36), Human, a neuropeptide Y (NPY) Y2 receptor agonist, is a powerful inhibitor of intestinal secretion.

HY-P1514

Peptide YY (PYY), human	Neuropeptide Y Receptor	Metabolic Disease Neurological Disease Endocrinology
Peptide YY (PYY) is a gut hormone that regulates appetite and inhibits pancreatic secretion. Peptide YY (PYY) can mediate its effects through the **Neuropeptide Y receptors**.

HY-P1324A

[cPP1-7,NPY19-23,Ala31,Aib32,Gln34]-hPancreatic polypeptide TFA	Neuropeptide Y Receptor	Neurological Disease
[cPP1-7,NPY19-23,Ala31,Aib32,Gln34]-hPancreatic Polypeptide is a potent and selective neuropeptide Y Y₅ receptor agonist with an IC₅₀ of 0.24 nM for binding to the hY₅ receptor. [cPP1-7,NPY19-23,Ala31,Aib32,Gln34]-hPancreatic Polypeptide induces a high amount of food intake.

HY-P1324

[cPP1-7,NPY19-23,Ala31,Aib32,Gln34]-hPancreatic Polypeptide	Neuropeptide Y Receptor	Neurological Disease
[cPP1-7,NPY19-23,Ala31,Aib32,Gln34]-hPancreatic Polypeptide is a potent and selective neuropeptide Y Y₅ receptor agonist with an IC₅₀ of 0.24 nM for binding to the hY₅ receptor. [cPP1-7,NPY19-23,Ala31,Aib32,Gln34]-hPancreatic Polypeptide induces a high amount of food intake.

Cat. No.	Product Name	Species	Source

HY-P72160

CXCR4 Protein, Human (GST) C-X-C chemokine Receptor type 4; CD184; CD184 antigen; Chemokine C X C motif; Receptor 4; Chemokine CXC Motif Receptor 4; CXC-R4; CXCR-4; CXCR4; CXCR4_HUMAN; D2S201E; FB22; Fusin; HM89; HSY3RR; LAP 3; LAP3; LCR1; LESTR; Leukocyte derived seven transmembrane domain Receptor; Leukocyte-derived seven transmembrane domain Receptor; Lipopolysaccharide associated protein 3; Neuropeptide Y Receptor Y3; NPY3R; NPYR; NPYRL; NPYY3; NPYY3R; Probable G protein coupled Receptor lcr1 homolog; SDF 1 Receptor; SDF-1 Receptor; SEVEN-TRANSMEMBRANE-SEGMENT Receptor; Stromal cell derived factor 1 Receptor; Stromal cell-derived factor 1 Receptor; WHIM; WHIMS	Human	E. coli