Ni | MedChemExpress (MCE) Life Science Reagents

By Targets:	Bacterial (1) Biochemical Assay Reagents (2) CD3 (1) Fluorescent Dye (1) IFNAR (1) Influenza Virus (1) Interleukin Related (1) Isotope-Labeled Compounds (1) Parasite (2) Toll-like Receptor (TLR) (1)
By Research Areas:	Cancer (3) Infection (3) Inflammation/Immunology (4)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-145645

Paridiprubart Ni-0101	Toll-like Receptor (TLR)	Inflammation/Immunology
Paridiprubart (NI-0101) is a humanised anti-TLR4 monoclonal antibody. Paridiprubart has the potential for the research of rheumatoid arthritis .

HY-19537

NI-57
NI-57 is an inhibitor of bromodomain and plant homeodomain finger-containing (BRPF) famlily of proteins, with IC₅₀s of 3.1, 46 and 140 nM for BRPF1, BRPF2 (BRD1) and BRPF3, respectively.

HY-P99199

Foralumab Ni-0401	CD3	Inflammation/Immunology
Foralumab (NI-0401) is a potent, orally active human monoclonal antibody targeting the CD3. Foralumab modulates immune responses by human cells in NSG mice that were reconstituted with human hematopoietic stem cells .

HY-101121

NI-42
NI-42 (compound 13-d), a structurally orthogonal chemical probe for the BRPFs, is a biased, potent inhibitor of the BRD of the BRPFs (IC₅₀s of BRPF1/2/3=7.9/48/260 nM; K_ds of BRPF1/2/3=40/210/940 nM) with excellent selectivity over nonclass IV BRD proteins .

HY-139701

NI-Pano

Others Cancer

NI-Pano (CH-03) is a novel hypoxia-activated KDAC inhibitor. NI-Pano (CH-03) is reduced in an O₂-dependent manner to release panobinostat.

NI-Pano	Others	Cancer
NI-Pano (CH-03) is a novel hypoxia-activated KDAC inhibitor. NI-Pano (CH-03) is reduced in an O₂-dependent manner to release panobinostat.

HY-P99191

Emapalumab Ni-0501	IFNAR	Inflammation/Immunology
Emapalumab (NI-0501) is a human monoclonal IgG1 antibody that noncompetitively inhibits IFN-γ. Emapalumab binds with high affinity (K_d= 1.4 pM) to both free IFN-γ as well as IFN-γ bound to its receptor. Emapalumab can be used in research of hemophagocytic lymphohistiocytosis (HLH) .

HY-136476C

Ni(II) protoporphyrin IX

Others Others

Ni(II) protoporphyrin IX is a metalloporphyrin that has a low tendency toward axial ligation, becomes distorted when bound to ferrochelatase .

Ni(II) protoporphyrin IX	Others	Others
Ni(II) protoporphyrin IX is a metalloporphyrin that has a low tendency toward axial ligation, becomes distorted when bound to ferrochelatase .

HY-P99424

Afasevikumab RG 7624; RO 5553110; Ni-1401	Interleukin Related	Inflammation/Immunology
Afasevikumab (RG 7624; RO 5553110; NI-1401) is a fully human monoclonal IgG1κ antibody neutralizing both IL-17A and IL-17F. Afasevikumab has anti-inflammatory activities .

HY-157917

Nitro-PAPS disodium dihydrate	Biochemical Assay Reagents	Others
Nitro-PAPS disodium dihydrate is a highly sensitive colometric reagent for Fe(II) detection with a maximal absorption wavelength of 592 nm. Nitro-PAPS disodium dihydrate is suitable for the determination of Fe(II) in serum and also be used to determine micro molar levels of Cu, Zn, Ni, Co and V .

HY-156291

XSJ2-46	Influenza Virus	Infection
XSJ2-46, 5'-amino NI analog, is an antiviral agent. XSJ2-46 has anti-Zika virus activity. XSJ2-46 exhibits reasonable inhibition of RNA-dependent RNA polymerases (RdRp) with an IC₅₀ value of 8.78 μM .

HY-126823

Phen Green SK diacetate (5/6-mixture) 2 Publications Verification PGSK diacetate (5/6-mixture)	Fluorescent Dye	Others
Phen green SK (PGSK) diacetate is a fluorescent heavy metal indicator that reacts with a variety of metal ions, including Fe2+, Cd2+, Co2+, Ni2+, Zn2+. PGSK diacetate displays excitation/emission maxima of 507/532 nm, respectively, and fluorescence is quenched upon interaction with metal ions

HY-111934

Cymarin	Others Parasite	Others Cancer
Cymarin, a cardiac glycoside, potently inhibits the Palytoxin (PTX)-induced K ⁺ release (IC₅₀=0.42 μM) . Cymarin reveals an antitumor activity against breast cancer and pancreatic cancer . Cymarin exhibits antifeedant and growth inhibitory effects as crop protectant .

HY-117386

Methoxyfenozide	Parasite	Others
Methoxyfenozide, a diacylhydrazine insecticide, selectively binds to lepidopteran ecdysone receptors (EcRs) over dipteran EcRs with K_d values of 0.5 and 124 nM, respectively. Methoxyfenozide is lethal to neonatal larvae of S. exigua, S. frugiperda, T. ni, O. nubilalis, L. pomonella, H. zea, and H. virescens (LC₅₀s=0.35, 0.2, 0.11, 0.18, 0.21, 0.79, and 3.12 mg/L, respectively).

HY-D0190

2-Thenoyltrifluoroacetone 1 Publications Verification HTTA; TTA; TTFA	Biochemical Assay Reagents	Infection Others Cancer
2-Thenoyltrifluoroacetone is a chelating agent. 2-Thenoyltrifluoroacetone can be used for the complexation of various metal ions including Mn(II), Co(III), Ni(II), et al.. 2-Thenoyltrifluoroacetone possesses antitubercular and cytotoxic activities. 2-Thenoyltrifluoroacetone is also used as common inhibitor of mitochondrial electron flux and to analyze the endothelial cell dysfunction. Besides, copper (II) complex of 2-Thenoyltrifluoroacetone has anticancer activity against K562 .

HY-143249

MtMetAP1-IN-1	Bacterial	Infection
MtMetAP1-IN-1 is an inhibitor of Mycobacterium tuberculosis (Mtb), targeting methionine aminopeptidase 1 (MetAP1). MtMetAP1-IN-1 exerts antimycobacterial activity .

HY-117386S

Methoxyfenozide-d9	Isotope-Labeled Compounds	Others
Methoxyfenozide-d₉ is the deuterium labeled Methoxyfenozide[1]. Methoxyfenozide, a diacylhydrazine insecticide, selectively binds to lepidopteran ecdysone receptors (EcRs) over dipteran EcRs with Kd values of 0.5 and 124 nM, respectively. Methoxyfenozide is lethal to neonatal larvae of S. exigua, S. frugiperda, T. ni, O. nubilalis, L. pomonella, H. zea, and H. virescens (LC50s=0.35, 0.2, 0.11, 0.18, 0.21, 0.79, and 3.12 mg/L, respectively)[2].

Cat. No.	Product Name	Type

HY-W011060

Cryptand 2.2.2 4,7,13,16,21,24-Hexaoxa-1,10-diazabicyclo[8.8.8]hexacosane	Biochemical Assay Reagents
Cryptand 2.2.2 is a metal ion chelator that can be used as a reducing agent and stabilizer to prepare nanoparticles. At room temperature, Cryptand 2.2.2 can serve as a host molecule, using the chelation effect to selectively bind desired ions (such as Zn ²⁺, Co ²⁺, Ni ²⁺, Cu ²⁺) .

HY-157917

Nitro-PAPS disodium dihydrate	Chelators
Nitro-PAPS disodium dihydrate is a highly sensitive colometric reagent for Fe(II) detection with a maximal absorption wavelength of 592 nm. Nitro-PAPS disodium dihydrate is suitable for the determination of Fe(II) in serum and also be used to determine micro molar levels of Cu, Zn, Ni, Co and V .

Cat. No.	Product Name

HY-K0210

Ni-NTA His-Tag Purification Agarose 5+ Cited Publications
MCE Ni-NTA His-Tag Purification Agarose, a 6% highly cross-linked agarose reagent, enables high-yield, high-purity purification of his-tagged proteins.

HY-K0220

Ni-NTA 6FF Prepacked Column
MCE Ni-NTA 6FF Prepacked Column is ideal for high performance purification of polyhistidine-tagged proteins expressed in E.coli, yeast, insect and mammalian expression systems.

Cat. No.	Product Name	Target	Research Area

HY-145645

Paridiprubart Ni-0101	Toll-like Receptor (TLR)	Inflammation/Immunology
Paridiprubart (NI-0101) is a humanised anti-TLR4 monoclonal antibody. Paridiprubart has the potential for the research of rheumatoid arthritis .

HY-P99199

Foralumab Ni-0401	CD3	Inflammation/Immunology
Foralumab (NI-0401) is a potent, orally active human monoclonal antibody targeting the CD3. Foralumab modulates immune responses by human cells in NSG mice that were reconstituted with human hematopoietic stem cells .

HY-P99191

Emapalumab Ni-0501	IFNAR	Inflammation/Immunology
Emapalumab (NI-0501) is a human monoclonal IgG1 antibody that noncompetitively inhibits IFN-γ. Emapalumab binds with high affinity (K_d= 1.4 pM) to both free IFN-γ as well as IFN-γ bound to its receptor. Emapalumab can be used in research of hemophagocytic lymphohistiocytosis (HLH) .

HY-P99424

Afasevikumab RG 7624; RO 5553110; Ni-1401	Interleukin Related	Inflammation/Immunology
Afasevikumab (RG 7624; RO 5553110; NI-1401) is a fully human monoclonal IgG1κ antibody neutralizing both IL-17A and IL-17F. Afasevikumab has anti-inflammatory activities .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-111934

Cymarin	Apocynaceae Structural Classification Classification of Application Fields Cardiacglycosides Source classification Other Diseases Plants Disease Research Fields Apocynum Steroids	Others Parasite
Cymarin, a cardiac glycoside, potently inhibits the Palytoxin (PTX)-induced K ⁺ release (IC₅₀=0.42 μM) . Cymarin reveals an antitumor activity against breast cancer and pancreatic cancer . Cymarin exhibits antifeedant and growth inhibitory effects as crop protectant .

Cat. No.	Product Name	Chemical Structure

HY-117386S

Methoxyfenozide-d9
Methoxyfenozide-d₉ is the deuterium labeled Methoxyfenozide[1]. Methoxyfenozide, a diacylhydrazine insecticide, selectively binds to lepidopteran ecdysone receptors (EcRs) over dipteran EcRs with Kd values of 0.5 and 124 nM, respectively. Methoxyfenozide is lethal to neonatal larvae of S. exigua, S. frugiperda, T. ni, O. nubilalis, L. pomonella, H. zea, and H. virescens (LC50s=0.35, 0.2, 0.11, 0.18, 0.21, 0.79, and 3.12 mg/L, respectively)[2].

Methoxyfenozide-d9

Methoxyfenozide-d₉ is the deuterium labeled Methoxyfenozide[1]. Methoxyfenozide, a diacylhydrazine insecticide, selectively binds to lepidopteran ecdysone receptors (EcRs) over dipteran EcRs with Kd values of 0.5 and 124 nM, respectively. Methoxyfenozide is lethal to neonatal larvae of S. exigua, S. frugiperda, T. ni, O. nubilalis, L. pomonella, H. zea, and H. virescens (LC50s=0.35, 0.2, 0.11, 0.18, 0.21, 0.79, and 3.12 mg/L, respectively)[2].

Cat. No.	Product Name	Application	Reactivity

HY-P81675

Nogo Antibody (YA1420)

ASY; Foocen; Ni220/250; NOGO; NOGOC; NSP; rat N; RTN X; Rtn4; RTN4-A; RTN4-B1; RTN4-B2; RTN4-C; Vp20
WB, IHC-P, ICC/IF, IP, FC Human

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Ni

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