OSM/IL-lβ

By Targets:	Interleukin Related (4) Parasite (1) Small Interfering RNA (siRNA) (1) STAT (1) TGF-β Receptor (1)
By Research Areas:	Cancer (3) Infection (1) Inflammation/Immunology (4)

Targets Recommended: Interleukin Related IRAK Itk

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-148692

OSM-SMI-10B	STAT	Cancer
OSM-SMI-10B a derivative of OSM-SMI-10. OSM-SMI-10B significantly reduces OSM-induced STAT3 phosphorylation in cancer cells upon co-incubation with OSM (Oncostatin M) .

HY-162238

OSM-S-106	Parasite	Infection
OSM-S-106 is a pro-inhibitor and that inhibition of PfAsnRS occurs via enzyme-mediated production of an Asn-OSM-S-106 adduct. OSM-S-106 inhibits protein translation and activates the amino acid starvation response. OSM-S-106 exhibits selective activity against Plasmodium blood and liver stages and low intrinsic clearance by human microsomes .

HY-148693

OSM-SMI-8

NSC642624
Interleukin Related Cancer

OSM-SMI-8 (NSC642624) is a potent OSM (oncostatin M) antagonist. OSM-SMI-8 has the potential for the research of cancer .

OSM-SMI-8 NSC642624	Interleukin Related	Cancer
OSM-SMI-8 (NSC642624) is a potent OSM (oncostatin M) antagonist. OSM-SMI-8 has the potential for the research of cancer .

HY-RS09850

OSM Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
OSM Human Pre-designed siRNA Set A contains three designed siRNAs for OSM gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

OSM Human Pre-designed siRNA Set A OSM Human Pre-designed siRNA Set A

HY-148695B

ADR58 sodium	Interleukin Related	Inflammation/Immunology
ADR58 sodium is a highly potent and selective human oncostatin M (OSM) antagonist, which can prevent the binding of OSM to the gp130 receptor and specifically antagonize OSM-mediated signaling. ADR58 sodium can be used in the research of rheumatoid arthritis related diseases .

HY-148695C

Truncated ADR58 sodium	Interleukin Related	Inflammation/Immunology
ADR58 sodium is a highly potent and selective human oncostatin M (OSM) antagonist, which can prevent the binding of OSM to the gp130 receptor and specifically antagonize OSM-mediated signaling. ADR58 sodium can be used in the research of rheumatoid arthritis related diseases .

HY-P99519

Vixarelimab KPL-716	Interleukin Related	Inflammation/Immunology
Vixarelimab (KPL-716) is a human anti-oncostatin M (OSM) monoclonal antibody that binds to the beta chain of the OSM receptor and inhibits IL-31 and OSM signalling. Vixarelimab can be used in studies of inflammatory skin diseases such as atopic dermatitis and itchy nodular rash .

HY-33354

Nitrochin 4-NQO
Nitrochin (4-NQO) is a chemical carcinogen. Nitrochin induces oncostatin-M (OSM) in esophageal cells. Nitrochin induces DNA damage, and induces apoptosis via a p53-dependent mitochondrial signaling pathway .

HY-P99590

Sotatercept ACE-011	TGF-β Receptor	Inflammation/Immunology Cancer
Sotatercept (ACE-011) is a soluble activin receptor 2A (ACVR2A) type IgG Fc fusion protein. Sotatercept combines activin and growth differentiation factor to try to restore the balance between growth promotion and growth inhibition signal pathways. Sotatercept has potential application in pulmonary arterial hypertension, anemia, bone loss, erythropoiesis, multiple myeloma (MM) osteolytic lesions .

Cat. No.	Product Name	Target	Research Area

HY-P99519

Vixarelimab KPL-716	Interleukin Related	Inflammation/Immunology
Vixarelimab (KPL-716) is a human anti-oncostatin M (OSM) monoclonal antibody that binds to the beta chain of the OSM receptor and inhibits IL-31 and OSM signalling. Vixarelimab can be used in studies of inflammatory skin diseases such as atopic dermatitis and itchy nodular rash .

HY-P99590

Sotatercept ACE-011	TGF-β Receptor	Inflammation/Immunology Cancer
Sotatercept (ACE-011) is a soluble activin receptor 2A (ACVR2A) type IgG Fc fusion protein. Sotatercept combines activin and growth differentiation factor to try to restore the balance between growth promotion and growth inhibition signal pathways. Sotatercept has potential application in pulmonary arterial hypertension, anemia, bone loss, erythropoiesis, multiple myeloma (MM) osteolytic lesions .

Species:	Human (9) Mouse (3) Rat (1)
Tag:	His (8) Tag Free (5) Avi (2)
Source:	HEK293 (6) E. coli Cell-free (1) E. coli (6)

Cat. No.	Compare	Product Name	Species	Source

HY-P70465

	OSM Protein, Human (His) Oncostatin-M; OSM	Human	E. coli
	OSM protein is a multifunctional growth regulator with dual functions of inhibiting tumor cell lines and stimulating the proliferation of AIDS-KS cells. It coordinates the production of cytokines, including IL-6, G-CSF, and GM-CSF, and binds to type I and type II OSM receptors, forming heterodimers with LIFR/IL6ST and OSMR/IL6ST, respectively. OSM Protein, Human (His) is the recombinant human-derived OSM protein, expressed by E. coli , with N-6*His labeled tag. The total length of OSM Protein, Human (His) is 196 a.a., with molecular weight of ~24 kDa.

HY-P7052

	OSM Protein, Human (227a.a) 1 Publications Verification rHuOSM; OSM	Human	E. coli
	OSM Protein, Human (227a.a) is a polypeptide chain containing 227 amino acids. Oncostatin M is a cytokine belonging to the IL-6 family that has multiple functions in hematopoiesis, mesenchymal stem cell differentiation, liver regeneration, heart remodeling, nociception, inflammation and metabolism.

HY-P7052A

	OSM Protein, Human (209a.a) rHuOSM; OSM	Human	E. coli
	OSM Protein, Human (209a.a) is a polypeptide chain containing 209 amino acids. Oncostatin M is a cytokine belonging to the IL-6 family that has multiple functions in hematopoiesis, mesenchymal stem cell differentiation, liver regeneration, heart remodeling, nociception, inflammation and metabolism.

HY-P74662

	OSM Protein, Human (HEK293) Oncostatin M; OSM	Human	HEK293
	OSM protein is a multifunctional growth regulator with dual functions of inhibiting tumor cell lines and stimulating the proliferation of AIDS-KS cells. It coordinates the production of cytokines, including IL-6, G-CSF, and GM-CSF, and binds to type I and type II OSM receptors, forming heterodimers with LIFR/IL6ST and OSMR/IL6ST, respectively. OSM Protein, Human (HEK293) is the recombinant human-derived OSM protein, expressed by HEK293 , with tag free. The total length of OSM Protein, Human (HEK293) is 196 a.a., with molecular weight of ~31.6 kDa.

HY-P70465G

	*GMP OSM* Protein, Human (His)** Oncostatin-M; OSM	Human	E. coli
	OSM protein is a multifunctional growth regulator with dual functions of inhibiting tumor cell lines and stimulating the proliferation of AIDS-KS cells. It coordinates the production of cytokines, including IL-6, G-CSF, and GM-CSF, and binds to type I and type II OSM receptors, forming heterodimers with LIFR/IL6ST and OSMR/IL6ST, respectively. GMP OSM Protein, Human (His) is the recombinant human-derived OSM protein, expressed by E. coli , with N-6*His labeled tag. The total length of GMP OSM Protein, Human (His) is 196 a.a., with molecular weight of ~28.0 kDa.

HY-P73331

	OSM Protein, Human (HEK293, His) Oncostatin M; OSM	Human	HEK293
	OSM protein is a multifunctional growth regulator with dual functions of inhibiting tumor cell lines and stimulating the proliferation of AIDS-KS cells. It coordinates the production of cytokines, including IL-6, G-CSF, and GM-CSF, and binds to type I and type II OSM receptors, forming heterodimers with LIFR/IL6ST and OSMR/IL6ST, respectively. OSM Protein, Human (HEK293, His) is the recombinant human-derived OSM protein, expressed by HEK293 , with C-His labeled tag. The total length of OSM Protein, Human (HEK293, His) is 196 a.a., with molecular weight of 30-40 kDa.

HY-P7052B

	OSM Protein, Human (227a.a, His) rHuOSM; OSM	Human	E. coli
	OSM protein is a multifunctional growth regulator with dual functions of inhibiting tumor cell lines and stimulating the proliferation of AIDS-KS cells. It coordinates the production of cytokines, including IL-6, G-CSF, and GM-CSF, and binds to type I and type II OSM receptors, forming heterodimers with LIFR/IL6ST and OSMR/IL6ST, respectively. OSM Protein, Human (227a.a, His) is the recombinant human-derived OSM protein, expressed by E. coli , with N-6*His labeled tag. The total length of OSM Protein, Human (227a.a, His) is 227 a.a., with molecular weight of ~27 kDa.

HY-P78502

	OSM Protein, Human (HEK293, His-Avi) Oncostatin M; OSM; MGC20461	Human	HEK293
	OSM protein is a multifunctional growth regulator with dual functions of inhibiting tumor cell lines and stimulating the proliferation of AIDS-KS cells. It coordinates the production of cytokines, including IL-6, G-CSF, and GM-CSF, and binds to type I and type II OSM receptors, forming heterodimers with LIFR/IL6ST and OSMR/IL6ST, respectively. OSM Protein, Human (HEK293, His-Avi) is the recombinant human-derived OSM protein, expressed by HEK293 , with C-Avi, C-His labeled tag. The total length of OSM Protein, Human (HEK293, His-Avi) is 196 a.a., with molecular weight of 30-40 kDa.

HY-P78187

	OSM Protein, Human (Biotinylated, HEK293, His-Avi) Oncostatin M; OSM; MGC20461	Human	HEK293
	OSM protein is a multifunctional growth regulator with dual functions of inhibiting tumor cell lines and stimulating the proliferation of AIDS-KS cells. It coordinates the production of cytokines, including IL-6, G-CSF, and GM-CSF, and binds to type I and type II OSM receptors, forming heterodimers with LIFR/IL6ST and OSMR/IL6ST, respectively. OSM Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived OSM protein, expressed by HEK293 , with C-Avi, C-His labeled tag. The total length of OSM Protein, Human (Biotinylated, HEK293, His-Avi) is 196 a.a., with molecular weight of 30-40 kDa.

HY-P700805

	OSM Protein, Mouse (HEK293, His) Oncostatin M; OSM; MGC20461; Oncostatin-M	Mouse	HEK293
	OSM protein is a multifunctional growth regulator that effectively inhibits the proliferation of tumor cell lines and regulates the production of cytokines, including IL-6, G-CSF, and GM-CSF produced by endothelial cells. It specifically binds to type II OSM receptors, forming a heterodimer composed of OSMR and IL6ST. OSM Protein, Mouse (HEK293, His) is the recombinant mouse-derived OSM protein, expressed by HEK293 , with C-His labeled tag. The total length of OSM Protein, Mouse (HEK293, His) is 182 a.a., with molecular weight of 35-50 kDa.

HY-P7275

	OSM Protein, Mouse rMuOSM; Oncostatin-M	Mouse	E. coli
	OSM Protein, Mouse is a gp130 cytokine family member, shows homeostatic and proinflammatory activities and can modify extracellular matrix.

HY-P7274

	OSM Protein, Mouse (HEK293) 1 Publications Verification rMuOSM; Oncostatin-M	Mouse	HEK293
	OSM Protein, Mouse (HEK293) is a gp130 cytokine family member, shows homeostatic and proinflammatory activities and can modify extracellular matrix.

HY-P702476

	TRPV2 Protein, Rat (Cell-Free, His) Transient receptor potential cation channel subfamILy V member 2; OSM-9-like TRP channel 2; OTRPC2; Stretch-activated channel 2B; VanILloid receptor-like protein 1; VRL-1	Rat	E. coli Cell-free
	The TRPV2 protein is a calcium-permeable nonselective cation channel with outward rectification and may be regulated by growth factors such as IGF1, PDGF, and morphogenetic neuropeptide/tau activator. TRPV2 Protein, Rat (Cell-Free, His) is the recombinant rat-derived TRPV2 protein, expressed by E. coli Cell-free , with N-10*His labeled tag. The total length of TRPV2 Protein, Rat (Cell-Free, His) is 761 a.a., with molecular weight of 88.2 kDa.


Products	In-stock - + Add to Cart
Cat. No.
Species
Source
Tag
Accession
Gene ID
Molecular Weight
Purity
Endotoxin Level
Biological Activity
Appearance
Formulation
Storage & Stability
Shipping
Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

Cat. No.	Product Name	Application	Reactivity

HY-P83068

Oncostatin M Antibody (YA2813)

Oncostatin-M (OSM)
WB Human, Mouse, Rat

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks

Inhibitors & Agonists

Inhibitory Antibodies

Recombinant Proteins

Antibodies

Name
Email *

	Sorry, but the email address you supplied was invalid.