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Results for "

Oxide Inhibitors

" in MedChemExpress (MCE) Product Catalog:

682

Inhibitors & Agonists

1

Screening Libraries

3

Fluorescent Dye

6

Biochemical Assay Reagents

17

Peptides

1

Inhibitory Antibodies

225

Natural
Products

34

Isotope-Labeled Compounds

1

Oligonucleotides

Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-126221B
    (R)-Aminocarnitine TFA

    Emeriamine TFA

    		 Biochemical Assay Reagents Metabolic Disease
    (R)-Aminocarnitine (Emeriamine) TFA is a fatty acid oxidation inhibitor that reduces hyperglycemia and ketosis. (R)-Aminocarnitine TFA can be used in the study of metabolic diseases .
    (R)-Aminocarnitine TFA
  • HY-148510
    HKB99

    		Phosphatase Cancer
    HKB99 is an allosteric inhibitor of phosphoglycerate mutase 1 (PGAM1). HKB99 inhibits the formation of invasive pseudopodia and increases the level of PAI-2 in vitro. HKB99 increases the oxidative stress, activates JNK/c-Jun and suppresses AKT and ERK. HKB99 can be used for the research of non-small-cell lung cancer (NSCLC) .
    HKB99
  • HY-163322
    MAO-A inhibitor 2

    		Monoamine Oxidase Neurological Disease
    MAO-A inhibitor 2 (compound HT4) is a monoamine oxidase A (MAO-A) inhibitor with an IC50 of 14.3 µM. MAO-A inhibitor 2 shows a less effect on MAO-B (IC50 of 106 µM) and shows almost ineffective on xanthine oxidase (XO). MAO-A inhibitor 2 can be used for the neurodegenerative disorders and oxidative stress research .
    MAO-A inhibitor 2
  • HY-162671
    BuChE-IN-12

    		Cholinesterase (ChE) Neurological Disease
    BuChE-IN-12 is a selective BuChE inhibitor (IC50=0.52 µM) that acts via affecting CAS and PAS sites and has potential effects against oxidative stress. BuChE-IN-12 can be used in the study of Alzheimer's disease .
    BuChE-IN-12
  • HY-158030
    HDAC6-IN-37

    		HDAC Neurological Disease
    HDAC6-IN-37 (compound W5) is an inhibitor of HDAC6 and has neuroprotective effects. HDAC6-IN-37 can restore the morphology of hippocampal neurons, reduce the expression of Aβ, Tau, and p-Tau proteins in the hippocampus of AD rats, and inhibit the formation of senile plaques and neurofibrillary tangles. Thus, HDAC6-IN-37 improves the Aβ/Cu 2+-induced AD model in rats, regulates oxidative stress status, and balances neurotransmitter disorders in brain tissue .
    HDAC6-IN-37
  • HY-N11844
    Quercetin 3-(6″-caffeoylsophoroside)

    		Amylases Metabolic Disease
    Quercetin 3-(6″-caffeoylsophoroside) is an orally active α-amylase inhibitor, with an IC50 of 73.66 μg/mL. Quercetin 3-(6″-caffeoylsophoroside) presents in thehydro-methanolic extract of Cardamine hirsuta Linn. Quercetin 3-(6″-caffeoylsophoroside) shows the antidiabetic activities by oxidative stress reduction and α-amylase inhibition. Quercetin 3-(6″-caffeoylsophoroside) can be used for diabetes mellitus research .
    Quercetin 3-(6″-caffeoylsophoroside)
  • HY-117607
    Alatrioprilat

    		Neprilysin Angiotensin-converting Enzyme (ACE) Cardiovascular Disease
    Alatrioprilat is an orally active inhibitor of angiotensin-converting enzyme (ACE) (IC50=19.6 nM; Ki=9.8 nM) and enkephailnase (IC50=6.1 nM; Ki=5.1 nM). Alatrioprilat plays a key role in the metabolism of hormonal peptides through the degradation of nitric oxide and atrial natriuretic factor (ANF). Alatrioprilat can be used in the study of cardiovascular diseases .
    Alatrioprilat
  • HY-N9814
    Shanciol B

    		NO Synthase Inflammation/Immunology
    Shanciol B, isolated from the ethyl acetate extract of the air-dried whole plant of Pholidota imbricate Hook, inhibits nitric oxide (NO) production and 1,1-diphenyl-2-picrylhydrazil (DPPH) radical scavenging activity . Shanciol B is a microsomal prostaglandin E synthase-1 (mPGES-1) inhibitor with anti-inflammatory activity .
    Shanciol B
  • HY-168074
    4″-C18 EGCG

    		Amylases Glycosidase Metabolic Disease Inflammation/Immunology
    4″-C18 EGCG is a potent inhibitor of α-amylase and α-glucosidase with IC50 values of 3.74 and 0.81 μM, respectively. 4″-C18 EGCG inhibits carbohydrate hydrolases, reduces oxidative stress and inflammation, and exhibits antidiabetic activity. 4″-C18 EGCG also downregulates proinflammatory cytokines and is cytotoxic to primary human peripheral blood mononuclear cells (PBMCs), non-cancer cell lines 3T3-L1, and HEK 293 at 50 μM .
    4″-C18 EGCG
  • HY-157157
    PAD4-IN-3

    		Protein Arginine Deiminase Cancer
    PAD4-IN-3 (compound 4B) is a PAD4 inhibitor with antitumor activity in vitro and in vivo. PAD4-IN-3 was covalently linked to RGD sequence peptide-modified chitosan (K-CRGDV), resulting in an enhanced oxidative stress-responsive nanoagent. K-CRGDV-PAD4-IN-3 can actively target tumors, inhibit PAD4 activity, block the formation of neutrophil extracellular traps (NETs), and improve the tumor immune microenvironment in response to the tumor microenvironment .
    PAD4-IN-3
  • HY-133794S
    Dasatinib N-oxide-d8

    		Drug Metabolite Cancer
    Dasatinib N-oxide-d8 is the deuterium labeled Dasatinib N-oxide. Dasatinib N-oxide is a minor metabolite of Dasatinib. Dasatinib is a potent and orally active dual Src/Bcr-Abl inhibitor[1][2].
    Dasatinib N-oxide-d8
  • HY-130579
    Vinyl-L-NIO hydrochloride

    		NO Synthase Neurological Disease
    Vinyl-L-NIO hydrochloride is a potent nitric oxide synthase (NOS) inhibitor. Vinyl-L-NIO hydrochloride inhibits the activity of NOS, reducing the production of nitric oxide .
    Vinyl-L-NIO hydrochloride
  • HY-114509
    Anilazine

    		Bacterial Infection Metabolic Disease
    Anilazine is a fungicide and inhibit the growth of Rhizobium sp. and E. coli. Anilazine inhibits glucose oxidation and succinate oxidation and also inhibits in vitro succinic dehydrogenase activity .
    Anilazine
  • HY-133110
    Afatinib N-Oxide

    		Drug Metabolite Others
    Afatinib N-Oxide is an impurity of Afatinib dimaleate in oxidative degradation. Afatinib dimaleate is an irreversible EGFR family inhibitor .
    Afatinib N-Oxide
  • HY-U00432B
    S-MTC acetate

    S-Methyl-L-thiocitrulline acetate

    		 Others Inflammation/Immunology
    S-MTC acetate (S-Methyl-L-thiocitrulline acetate) acts as a powerful inhibitor of inducible nitric oxide synthase, favoring the inhibition of constitutive (neuronal) nitric oxide synthase over inducible (endothelial) nitric oxide synthase.
    S-MTC acetate
  • HY-129876
    D-NAME hydrochloride

    D-NG-nitroarginine methyl ester hydrochloride; H-D-Arg(NO2)-OMe hydrochloride

    		 NO Synthase Neurological Disease
    D-NAME (D-NG-nitroarginine methyl ester) hydrochloride is a potent nitric oxide synthase (NOS) inhibitor. D-NAME hydrochloride inhibits the activity of NOS, reducing the production of nitric oxide .
    D-NAME hydrochloride
  • HY-113929R
    Loperamide oxide (Standard)

    		Others Inflammation/Immunology
    Loperamide oxide (Standard) is the analytical standard of Loperamide oxide. This product is intended for research and analytical applications. Loperamide oxide (R-58425) is a orally active prodrug of the Loperamide (HY-156131). Loperamide oxide incubation with the contents of the intestinal lumen inhibits fluid secretion under aerobic conditions .
    Loperamide oxide (Standard)
  • HY-123260
    S12340

    		LDLR Cardiovascular Disease
    S12340 is a a inhibitor of the oxidative modification of low-density lipoprotein and shows protective effect on cardiac cells exposed to oxidative stress .
    S12340
  • HY-131901
    Phenylarsine oxide

    Oxophenylarsine; PhAsO; Arsenosobenzene

    		 Phosphatase Others
    Phenylarsine oxide (PAO), an inhibitor of endocytosis, inhibits PTPε with an IC50 of 18 μM. Phenylarsine oxide (PAO) inhibits oxygen consumption and decreases cellular ATP content overlap with those used to inhibit protein internalization .
    Phenylarsine oxide
  • HY-W698343
    NG-Hydroxy-L-arginine acetate

    NOHA acetate

    		 Others Others
    NG-Hydroxy-L-arginine acetate (NOHA acetate) serves as a physiological inhibitor of arginase, playing a crucial role in the conversion of arginine to nitric oxide and citrulline by nitric oxide synthase.
    NG-Hydroxy-L-arginine acetate
  • HY-N7263
    Galanthamine N-Oxide

    		Cholinesterase (ChE) Neurological Disease
    Galanthamine N-Oxide is an alkaloid obtained from the bulbs of Zephyranthes concolor. Galanthamine N-Oxide inhibits electric eel acetylcholinesterase (AChE) with an EC50 of 26.2 μM. Galanthamine N-Oxide is a prominent inhibitor of substrate accommodation in the active site of the Torpedo californica AChE (TcAChE), hAChE and hBChE enzymes .
    Galanthamine N-Oxide
  • HY-131574
    Heliosupine N-oxide

    		mAChR Neurological Disease
    Heliosupine N-oxide, Heliosupin metabolite, inhibits muscarinic acetylcholine receptor (mAChR) with the IC50 of 350 μM. Heliosupine N-oxide is a pyrrolizidine alkaloid (PA) .
    Heliosupine N-oxide
  • HY-133795
    Lucanthone N-oxide

    		Others Others
    Lucanthone N-oxide is the nitrogen oxide of Lucanthone (HY-B2098), an endonuclease inhibitor of Apurinic endonuclease-1 (APE-1) .
    Lucanthone N-oxide
  • HY-50202
    Etomoxir
    85+ Cited Publications

    (R)-(+)-Etomoxir

    		 Apoptosis Metabolic Disease Cancer
    Etomoxir ((R)-(+)-Etomoxir) is an irreversible inhibitor of carnitine palmitoyltransferase 1a (CPT-1a), inhibits fatty acid oxidation (FAO) through CPT-1a and inhibits palmitate β-oxidation in human, rat and guinea pig.
    Etomoxir
  • HY-100636
    Gefitinib N-oxide

    		EGFR Cancer
    Gefitinib N-oxide is the N-oxide derivative of Gefitinib. Gefitinib is an EGFR tyrosine kinase inhibitor, with IC50 of 2-37 nM in NR6wtEGFR cells .
    Gefitinib N-oxide
  • HY-100636A
    Gefitinib N-oxide hydrochloride

    		EGFR Cancer
    Gefitinib N-oxide hydrochloride is the N-oxide derivative of Gefitinib. Gefitinib is an EGFR tyrosine kinase inhibitor, with IC50 of 2-37 nM in NR6wtEGFR cells .
    Gefitinib N-oxide hydrochloride
  • HY-100639
    Roflumilast N-oxide

    		Drug Metabolite Phosphodiesterase (PDE) Inflammation/Immunology
    Roflumilast N-oxide is a PDE type 4 inhibitor.
    Roflumilast N-oxide
  • HY-N8120
    Bisabolone oxide A

    		Glycosidase Metabolic Disease
    Bisabolone oxide A is an α-glucosidase inhibitor .
    Bisabolone oxide A
  • HY-50202A
    Etomoxir sodium salt
    85+ Cited Publications

    (R)-(+)-Etomoxir sodium salt

    		 Apoptosis Metabolic Disease Cancer
    Etomoxir((R)-(+)-Etomoxir) sodium salt is an irreversible inhibitor of carnitine palmitoyltransferase 1a (CPT-1a), inhibits fatty acid oxidation (FAO) through CPT-1a and inhibits palmitate β-oxidation in human, rat and guinea pig .
    Etomoxir sodium salt
  • HY-114509R
    Anilazine (Standard)

    		Bacterial Infection Metabolic Disease
    Anilazine (Standard) is the analytical standard of Anilazine. This product is intended for research and analytical applications. Anilazine is a fungicide and inhibit the growth of Rhizobium sp. and E. coli. Anilazine inhibits glucose oxidation and succinate oxidation and also inhibits in vitro succinic dehydrogenase activity .
    Anilazine (Standard)
  • HY-133798
    Sorafenib N-oxide

    		Cytochrome P450 Drug Metabolite Cancer
    Sorafenib N-oxide is an active metabolite of sorafenib (HY-10201). Sorafenib N-oxide is a linear-mixed inhibitor of microsomal CYP3A4, with a Ki of 15 μM .
    Sorafenib N-oxide
  • HY-N12139
    Nitric oxide production-IN-1

    		NO Synthase Cancer
    Nitric oxide production-IN-1（Compound 1） is a inhibitor of NO Production which isolated from Tupistra chinensis. Nitric oxide production-IN-1（Compound 1） inhibits NO production in rat abdomen macrophages induced by lipopolysaccharide
    Nitric oxide production-IN-1
  • HY-151241
    Sinomenine N-oxide

    (+)-Sinomenine N-Oxide

    		 NO Synthase Inflammation/Immunology
    Sinomenine N-oxide has anti-angiogenic, anti-inflammatory and anti-rheumatic effects. Sinomenine N-oxide is also a NO production inhibitor, with an IC50 value of 23.04 μM .
    Sinomenine N-oxide
  • HY-158421
    MS-L6

    		Oxidative Phosphorylation Mitochondrial Metabolism Cancer
    MS-L6 is a potent inhibitor of oxidative phosphorylation (OXPHOS) that can acts as electron transport chain complexes I (ETC-I) combining inhibition of NADH oxidation and uncoupling effect .
    MS-L6
  • HY-W420033
    (S)-(+)-Etomoxir

    		Acyltransferase Others
    (S)-(+)-Etomoxir is the S enantiomer of Etomoxir (HY-50202). Etomoxir is an irreversible inhibitor of carnitine palmitoyltransferase 1a (CPT-1a), inhibits fatty acid oxidation (FAO) through CPT-1a and inhibits palmitate β-oxidation in human, rat and guinea pig .
    (S)-(+)-Etomoxir
  • HY-101175
    3-Bromo-7-nitroindazole

    		NO Synthase Neurological Disease
    3-Bromo-7-nitroindazole is a more potent and selective inhibitor of neuronal nitric oxide synthase (nNOS) than eNOS or inducible nitric oxide synthase (iNOS). 3-Bromo-7-nitroindazole affects the intercellular messenger nitric oxide (NO) synthesis throughout the body and brain .
    3-Bromo-7-nitroindazole
  • HY-113929
    Loperamide oxide

    R-58425

    		 Opioid Receptor Inflammation/Immunology
    Loperamide oxide (R-58425) is a orally active prodrug of the Loperamide (HY-156131). Loperamide oxide incubation with the contents of the intestinal lumen inhibits fluid secretion under aerobic conditions .
    Loperamide oxide
  • HY-N0815
    Resibufogenin
    5+ Cited Publications

    Bufogenin; Recibufogenin

    		 Others Cancer
    Resibufogenin is a component of cinobufogenin and has the function of inhibiting oxidative stress and tumor regeneration.
    Resibufogenin
  • HY-U00432
    S-MTC

    S-Methyl-L-thiocitrulline

    		 NO Synthase Neurological Disease
    S-MTC is a selective type I nitric oxide synthase (NOS) inhibitor.
    S-MTC
  • HY-Y0351
    Phenylthiourea

    Phenylthiocarbamide

    		 Tyrosinase Others
    Phenylthiourea (Phenylthiocarbamide) is an inhibitor of phenoloxidase. Phenylthiourea inhibits enzymatic oxidation of DOPA by phenoloxidase (Ki: 0.21 μM) .
    Phenylthiourea
  • HY-114548
    Ebselen oxide

    		Guanylate Cyclase Infection
    Ebselen oxide, the selenone analogue of Ebselen, covalently modifies diguanylate cyclase (DGC) to inhibit c-di-GMP-receptor interactions and reduces DGC activity. Ebselen oxide also inhibits alginate production (IC50=14 μM) by Pseudomonas aeruginosa. Ebselen oxide inhibits HDAC1, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7, HDAC8, and HDAC9 (IC50 ranging from 0.2 to 4.7 μM) .
    Ebselen oxide
  • HY-116145
    MHY884

    		Tyrosinase NF-κB Inflammation/Immunology
    MHY884 is a tyrosinase inhibitor that suppresses UVB-induced activation of NF-κB signaling pathway through the downregulation of oxidative stress. MHY884 suppresses oxidative stress in the melanoma cells and attenuates UVB-induced oxidative stress, resulting in reduced NF-κB activity in irradiated mice. MHY884 is promising for research of UVB-induced skin damage .
    MHY884
  • HY-W011245R
    Ranitidine S-oxide (Standard)

    		Drug Metabolite Metabolic Disease
    Ranitidine S-oxide (Standard) is the analytical standard of Ranitidine S-oxide. This product is intended for research and analytical applications. Ranitidine S-oxide is the metabolite of Ranitidine (HY-B0693). Ranitidine is a potent, selective and orally active histamine H2-receptor antagonist with an IC50 of 3.3 μM that inhibits gastric secretion .
    Ranitidine S-oxide (Standard)
  • HY-W104819
    4-Hydroxyphenylglyoxylate

    4-Hydroxyphenylglyoxylic acid; 4-HPGA

    		 Others Metabolic Disease
    4-Hydroxyphenylglyoxylate (4-Hydroxyphenylglyoxylic acid) is an inhibitor of carnitine palmitoyltransferase I (CPT I). 4-Hydroxyphenylglyoxylate can be used to study sensitivity changes in CPT I of liver mitochondria and fatty acid oxidation by isolated hepatocytes. 4-Hydroxyphenylglyoxylate can inhibits fatty acid oxidation .
    4-Hydroxyphenylglyoxylate
  • HY-127029A
    Umbelliprenin

    		NO Synthase Lipoxygenase Neurological Disease Inflammation/Immunology Cancer
    Umbelliprenin, a prenylated coumarin, is an antioxidant with anticancer, anti-inflammatory and immunomodulatory effects. Umbelliprenin inhibits lipoxygenase managing the inflammation pathways. In inflammatory macrophages, Umbelliprenin suppresses nitric oxide production as well as inducible nitric oxide synthase (NO synthase) .
    Umbelliprenin
  • HY-136408
    Malonyl CoA lithium

    Malonyl coenzyme A lithium

    		 Mitochondrial Metabolism Metabolic Disease
    Malonyl CoA (Malonyl Coenzyme A) lithium is an inhibitor of carnitine palmitoyl transferase 1 (CPT1). High Malonyl CoA lithium concentrations suppress fatty acid oxidation, while low Malonyl CoA lithium concentrations are permissive for fat oxidation .
    Malonyl CoA lithium
  • HY-W643128
    Carlina oxide

    		Cholinesterase (ChE) Infection
    Carlina oxide is an AChE inhibitor and antioxidant that kills Culex pipiens larvae (LC50=1.39 μg/mL). Carlina oxide is cytotoxic to vertebrate cells, human dermis, HCT116 and MDA-MB231 cell lines .
    Carlina oxide
  • HY-Z7660
    Lansoprazole N-oxide

    		Drug Metabolite Metabolic Disease Inflammation/Immunology
    Lansoprazole N-oxide (Comound 2) is the overoxidized by-product found in the synthesis of the proton pump inhibitor Lansoprazole (HY-13662). Lansoprazole N-oxide is promising for research of duodenal and gastric ulcers, reflux oesophagitis, and Zollinger–Ellison syndrome .
    Lansoprazole N-oxide
  • HY-N10218
    Sterpurol D

    		Others Inflammation/Immunology
    Sterpurol D is a compound of the sterpurane sesquiterpenoid. Sterpurol D significantly inhibits nitric oxide (NO) production .
    Sterpurol D
  • HY-U00432A
    S-MTC dihydrochloride

    S-Methyl-L-thiocitrulline dihydrochloride

    		 NO Synthase Neurological Disease
    S-MTC (S-Methyl-L-thiocitrulline) dihydrochloride is a selective type I nitric oxide synthase (NOS) inhibitor.
    S-MTC dihydrochloride