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Ozanimod

" in MedChemExpress (MCE) Product Catalog:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-12288
    Ozanimod
    2 Publications Verification

    RPC-1063

    		 LPL Receptor Neurological Disease Inflammation/Immunology
    Ozanimod (RPC-1063), a sphingosine 1-phosphate (S1P) receptor modulator that binds with high affinity selectively to S1P receptor subtypes 1 (S1P1) and 5 (S1P5). Ozanimod has modulate effect for hS1P1 and hS1P5 receptor with EC50s of 1.03 nM and 8.6 nM, respectively. Ozanimod can be used for the research of relapsing multiple sclerosis (MS) .
    <em>Ozanimod</em>
  • HY-12288A
    Ozanimod hydrochloride
    2 Publications Verification

    RPC-1063 hydrochloride

    		 LPL Receptor Neurological Disease Inflammation/Immunology
    Ozanimod (RPC-1063) hydrochloride, a sphingosine 1-phosphate (S1P) receptor modulator that binds with high affinity selectively to S1P receptor subtypes 1 (S1P1) and 5 (S1P5). Ozanimod hydrochloride has modulate effect for hS1P1 and hS1P5 receptor with EC50s of 1.03 nM and 8.6 nM, respectively. Ozanimod hydrochloride can be used for the research of relapsing multiple sclerosis (MS) .
    <em>Ozanimod</em> hydrochloride
  • HY-136578
    RP101988

    		LPL Receptor Drug Metabolite Inflammation/Immunology Cancer
    RP101988, the major active metabolite of Ozanimod, is a selective, potent S1PR1 (sphingosine-1-phosphate receptor 1) agonist, with EC50s of 0.19 nM and 32.8 nM for S1PR1 and S1PR5, respectivlely .
    RP101988
  • HY-136577
    RP101442

    		LPL Receptor Drug Metabolite Inflammation/Immunology
    RP101442, an active metabolite of Ozanimod, is a selective, potent S1PR1 (sphingosine-1-phosphate receptor 1) agonist, with EC50s of 2.6 nM and 171 nM for S1PR1 and S1PR5, respectively .
    RP101442
  • HY-136576
    RP101075

    		LPL Receptor Drug Metabolite Inflammation/Immunology
    RP101075, an active metabolite of Ozanimod, is a potent, orally active S1PR (sphingosine-1-phosphate receptor 1) agonist, with an EC50 of 0.27 nM. RP101075 displays >100-fold selectivity over S1PR5 (EC50=5.9 nM) and >10000-fold over S1PR 2, 3, and 4. RP101075 displays superior cardiovascular safety profile .
    RP101075

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