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Results for "

P2Y1

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (1) Arrestin (2) Endogenous Metabolite (1) P2X Receptor (2) P2Y Receptor (18)
By Research Areas:	Cancer (2) Cardiovascular Disease (8) Inflammation/Immunology (5) Neurological Disease (4)

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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-149454

P2Y1/P2Y12 antagonist-1	P2Y Receptor	Cancer
P2Y1/P2Y12 antagonist-1 (compound 24w) is an orally available dual inhibitor of *P2Y1* and P2Y12 with antiplatelet activity. P2Y1/P2Y12 antagonist-1 inhibits ADP-induced platelet aggregation in rabbit plasma with an IC₅₀ of 4.23 μM. P2Y1/P2Y12 antagonist-1 exhibits potent inhibitory effects in rat thrombosis model.

HY-13831

BPTU BMS-646786	P2Y Receptor	Neurological Disease Cancer
BPTU (BMS-646786) is a non-nucleotide *P2Y₁* receptor allosteric antagonist with antithrombotic activity. BPTU is able to block the P2Y1 receptor located at the neuromuscular junction of the gastrointestinal tract .

HY-108662

PIT 2,2'-Pyridylisatogen tosylate	P2Y Receptor	Inflammation/Immunology
PIT (2,2'-Pyridylisatogen tosylate) is a selective and non-competitive antagonist of P2Y1 receptor with an IC₅₀ value of 0.14 μM for human P2Y1 receptor. PIT antagonizes P2Y1 receptor signaling without affecting nucleotide binding. PIT is an irreversible antagonist of responses to ATP at metabotropic purinoceptors (of the P2Y family) in some smooth muscles. PIT can be used for the research of chronic bronchitis and asthma .

HY-108658

MRS2500 tetraammonium	P2Y Receptor	Cardiovascular Disease
MRS2500 tetraammonium is a potent, selective and stable antagonist of the *P2Y1* receptor (K_i=0.78 nM for recombinant human P2Y1 receptor). MRS2500 tetraammonium inhibits the ADP-induced aggregation of human platelets with an IC₅₀ value of 0.95 nM. Antithrombotic activity .

HY-113723

MRS2298	P2Y Receptor	Cardiovascular Disease
MRS2298? is a potent acyclic *P2Y1* receptor antagonist with a K_i of 29.6 nM. MRS2298 inhibits the ADP-induced aggregation of human platelets with an IC₅₀ of 62.8 nM. MRS2298 inhibits Ca ²⁺ rise in platelets with an IC₅₀ of 810 nM .

HY-101308

MRS2179 tetrasodium
MRS2179 tetrasodium is a competitive *P2Y1* receptor antagonist, with a K_b of 102 nM and a pA₂ of 6.99 for turkey P2Y1 receptor. MRS2179 tetrasodium is selective for P2Y1 over P2X1 (IC₅₀=1.15 µM), P2X3 (12.9 µM), P2X2, P2X4, P2Y2, P2Y4, and P2Y6 receptors . MRS2179 tetrasodium inhibits platelet aggregation .

HY-101308A

MRS2179 tetrasodium hydrate	P2Y Receptor	Cardiovascular Disease
MRS2179 tetrasodium hydrate is a competitive *P2Y1* receptor antagonist, with a K_b of 102 nM and a pA₂ of 6.99 for turkey P2Y1 receptor. MRS2179 tetrasodium hydrate is selective for P2Y1 over P2X1 (IC₅₀=1.15 µM), P2X3 (12.9 µM), P2X2, P2X4, P2Y2, P2Y4, and P2Y6 receptors . MRS2179 tetrasodium hydrate inhibits platelet aggregation .

HY-111557

YM-254890 Maximum Cited Publications 7 Publications Verification	P2Y Receptor	Cardiovascular Disease
YM-254890 is a selective G_αq/11 protein inhibitor isolated from Chromobacterium sp. YM-254890 shows no inhibition of other G protein subtypes. YM-254890 inhibits platelet aggregation induced by ADP by blocking the *P2Y₁* signal transduction pathway, with an IC₅₀ value below 0.6 μM .

HY-N7740

Adenosine 2',5'-diphosphate sodium	P2Y Receptor Endogenous Metabolite	Others
Adenosine 2',5'-diphosphate sodium is a competitive *P2Y1* antagonist. Adenosine 2',5'-diphosphate sodium exhibits non-selective antagonism at recombinant and human platelet P2X1 receptors .

HY-108657

MRS2279	P2Y Receptor	Neurological Disease
MRS2279 is a selective and high affinity *P2Y1* receptor antagonist, with a K_i of 2.5 nM and an IC₅₀ of 51.6 nM. MRS2279 competitively inhibits ADP-promoted platelet aggregation with an apparent affnity (pK_B=8.05) .

HY-108657A

MRS2279 diammonium 1 Publications Verification	P2Y Receptor	Neurological Disease
MRS2279 diammonium is a selective and high affinity *P2Y1* receptor antagonist, with a K_i value of 2.5 nM and an IC₅₀ value of 51.6 nM. MRS2279 diammonium competitively inhibits ADP-promoted platelet aggregation with an pK_b value of 8.05 .

HY-D1199

Blue FPG-A trisodium	P2X Receptor P2Y Receptor	Inflammation/Immunology
Blue FPG-A trisodium is a selective antagonist of P2X₁ receptor and P2Y₁ receptor with IC₅₀ values of 35.5 μM and 2.6 μM, respectively. Blue FPG-A trisodium is a structural isomer of the components of Reactive Blue 2 (RB2) .

HY-108656A

MRS2365 trisodium	P2Y Receptor Arrestin	Cardiovascular Disease
MRS2365 trisodium is a potent and selective P2Y1 receptor (EC₅₀=0.4 nM)/[ ³⁵S]GTPγS binding/β-arrestin 2 recruitment agonist. MRS2365 trisodium relieves mechanical allodynia and increases mechanical sensitivity .

HY-13104

MRS 2578 5 Publications Verification	P2Y Receptor Apoptosis	Cardiovascular Disease
MRS 2578 is a selective and potent P2Y6 receptor antagonist with IC₅₀s of 37 nM (human) and 98 nM (rat). MRS 2578 exhibits insignificant activity at P2Y1, P2Y2, P2Y4, and P2Y11 receptors .

HY-110322A

PPTN	P2Y Receptor	Inflammation/Immunology
PPTN is a potent, high-affinity, competitive and highly selective P2Y14 receptor antagonist with a K_B value of 434 pM. PPTN exhibits no agonist or antagonist effect at the P2Y1, P2Y2, P2Y4, P2Y6, P2Y11, P2Y12, or P2Y13 receptors. Anti-inflammatory and immune activity .

HY-110322

PPTN hydrochloride 1 Publications Verification	P2Y Receptor	Inflammation/Immunology
PPTN hydrochloride is a potent, high-affinity, competitive and highly selective P2Y14 receptor antagonist with a K_B value of 434 pM. PPTN hydrochloride exhibits no agonist or antagonist effect at the P2Y1, P2Y2, P2Y4, P2Y6, P2Y11, P2Y12, or P2Y13 receptors. Anti-inflammatory and anti-immune activity .

HY-108656

MRS2365	P2Y Receptor Arrestin	Cardiovascular Disease
MRS2365 is a potent and selective P2Y1 receptor (EC₅₀=0.4 nM) /[ ³⁵S]GTPγS binding/β-arrestin 2 recruitment agonist with an EC₅₀ of 0.4 nM. MRS2365 relieves mechanical allodynia and increases mechanical sensitivity. MRS2365 shows little agonist or antagonist activity at the P2Y12 or P2Y13 receptors .

HY-108672

NF157	P2Y Receptor	Inflammation/Immunology
NF157 is a highly selective nanomolar P2Y11 antagonist with a pK_i of 7.35. The IC₅₀s are 463 nM, 1811 µM, 170 µM for P2Y11 (K_i=44.3 nM), P2Y1 (K_i=187 µM), P2Y2 (K_i=28.9 µM), respectively . NF157, significantly reduces expression of metalloproteinase (MMP)-3, MMP-13, can be used in the treatment of osteoarthritis (OA) .

HY-108648

2-Methylthioadenosine diphosphate trisodium 2-Methylthio-ADP trisodium	P2Y Receptor	Neurological Disease
2-Methylthioadenosine diphosphate trisodium is a potent purinergic P2Y receptors agonist, with EC₅₀s of 19, 6.2, and 5 nM for human P2Y13, mouse P2Y13 and human P2Y12, respectively. 2-Methylthioadenosine diphosphate trisodium has pEC₅₀s of 8.29 and 5.75 for human P2Y1 and rat P2Y6, respectively. 2-Methylthioadenosine diphosphate trisodium induces platelet aggregation and shape change, and inhibits cyclic AMP accumulation in platelets exposed to prostaglandin E1 .

HY-130284

NF864

P2X Receptor Cardiovascular Disease

NF864 is a selectivelyP2X1 receptorinhibitor in human platelets .

NF864	P2X Receptor	Cardiovascular Disease
NF864 is a selectivelyP2X1 receptorinhibitor in human platelets .

YM-254890 5+ Cited Publications	Cardiovascular Disease Structural Classification Natural Products Microorganisms Classification of Application Fields Source classification Disease Research Fields	P2Y Receptor
YM-254890 is a selective G_αq/11 protein inhibitor isolated from Chromobacterium sp. YM-254890 shows no inhibition of other G protein subtypes. YM-254890 inhibits platelet aggregation induced by ADP by blocking the *P2Y₁* signal transduction pathway, with an IC₅₀ value below 0.6 μM .

Adenosine 2',5'-diphosphate sodium	Classification of Application Fields Ketones, Aldehydes, Acids Source classification Other Diseases Endogenous metabolite Disease Research Fields	P2Y Receptor Endogenous Metabolite
Adenosine 2',5'-diphosphate sodium is a competitive *P2Y1* antagonist. Adenosine 2',5'-diphosphate sodium exhibits non-selective antagonism at recombinant and human platelet P2X1 receptors .

Species:	Human (2)
Tag:	His (1) Flag (2)
Source:	Sf9 insect cells (2)

Cat. No.	Compare	Product Name	Species	Source

HY-P701629

	P2Y1 Protein, Human (Sf9, FLAG) P2RY1; P2Y purinoceptor 1; P2Y1; ADP receptor; Purinergic receptor	Human	Sf9 insect cells
	The P2Y1 protein acts as a receptor for extracellular adenine nucleotides, specifically ADP. In platelets, ADP binding activates phospholipase C, leading to intracellular calcium mobilization, platelet shape changes, and aggregation. P2Y1 Protein, Human (Sf9, FLAG) is the recombinant human-derived P2Y1 protein, expressed by Sf9 insect cells , with N-Flag labeled tag. The total length of P2Y1 Protein, Human (Sf9, FLAG) is 372 a.a., .

HY-P701630

	P2Y1 Protein, Human (Sf9, FLAG, His) P2RY1; P2Y purinoceptor 1; P2Y1; ADP receptor; Purinergic receptor	Human	Sf9 insect cells
	The P2Y1 protein acts as a receptor for extracellular adenine nucleotides, specifically ADP. In platelets, ADP binding activates phospholipase C, leading to intracellular calcium mobilization, platelet shape changes, and aggregation. P2Y1 Protein, Human (Sf9, FLAG, His) is the recombinant human-derived P2Y1 protein, expressed by Sf9 insect cells , with C-10*His, N-Flag labeled tag. The total length of P2Y1 Protein, Human (Sf9, FLAG, His) is 372 a.a., .


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P2Y1

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