PAI-1

By Targets:	PAI-1 (15) Amyloid-β (1) Androgen Receptor (1) Antibiotic (1) Apoptosis (3) ERK (1) JNK (1) Myosin (1) Potassium Channel (1) Progesterone Receptor (1) TGF-β Receptor (1)
By Research Areas:	Cancer (7) Cardiovascular Disease (6) Endocrinology (1) Infection (1) Inflammation/Immunology (3) Metabolic Disease (2) Neurological Disease (1)

Targets Recommended: PAI-1

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-120516

CDE-096	PAI-1	Cardiovascular Disease
CDE-096 is a potent inhibitor of *PAI-1. CDE-096 prevents PAI-1* from inactivating tPA and uPA with similar potency (IC₅₀=30 and 25 nM, respectively) and is active against glycosylated PAI-1, as well as PAI-1 derived from several species (IC₅₀=19, 22 and 18 nM for murine, rat, and Porcine PAI-1, respectively) ^[1].

HY-117724

AZ3976	PAI-1	Cardiovascular Disease
AZ3976 is a potent plasminogen activator inhibitor type 1 (PAI-1) inhibitor with an IC₅₀ value of 26 μM in an enzymatic chromogenic assay. AZ3976 is active with an IC₅₀ of 16 μM in a plasma clot lysis assay. AZ3976 does not bind to active PAI-1 but bound reversibly to latent PAI-1. AZ3976 inhibits PAI-1 by enhancing the latency transition of active PAI-1. AZ3976 displays profibrinolytic activities in a human plasma clot lysis assay ^[1].

HY-122098

Diaplasinin PAI-749	PAI-1	Cardiovascular Disease
Diaplasinin (PAI-749) is a plasminogen activator inhibitor-1 (PAI-1) inhibitor with IC₅₀ of 295 nM. Diaplasinin has antithrombotic efficacy ^[1].

HY-106508

Fendosal HP 129; P 71-0129	PAI-1	Inflammation/Immunology
Fendosal (HP 129) is an orally active, potent non-steroidal anti-inflammatory agent. Fendosal (HP 129) is also an inhibitor of Plasminogen activator inhibitor-1 (PAI-1) ^[1].

HY-N10227

Geodin	PAI-1 Antibiotic	Infection Inflammation/Immunology
Geodin, a fungal metabolite, shows antibacterial activity. Geodin also is an inhibitor of plasminogen activator inhibitor- 1 (PAI-1) ^[1].

HY-14759

Aleplasinin PAZ-417	PAI-1 Amyloid-β	Neurological Disease
Aleplasinin is an orally active, potent, BBB-penetrated and selectiveSERPINE1 (PAI-1, Plasminogen activator inhibitor-1) inhibitor. Aleplasinin increases amyloid-β (Aβ) catabolism and ameliorates amyloid-related pathology. Aleplasinin improves memory deficiency. Aleplasinin can be used for Alzheimer's disease research ^[1] .

HY-101761A

TM5441 sodium	PAI-1 Apoptosis
TM5441 is an orally bioavailable inhibitor of plasminogen activator inhibitor-1 (PAI-1), has IC₅₀ values between 13.9 and 51.1 μM. TM5441 induces intrinsic apoptosis in several human cancer cell lines. TM5441 attenuates Nω-nitro-l-arginine methyl ester-induced cardiac hypertension and vascular senescence ^[1] .

HY-100447

TM5275 sodium

4 Publications Verification

PAI-1 Cardiovascular Disease Cancer

TM5275 sodium is a plasminogen activator inhibitor (PAI-1) with an IC₅₀ of 6.95 μM.

TM5275 sodium 4 Publications Verification	PAI-1	Cardiovascular Disease Cancer
TM5275 sodium is a plasminogen activator inhibitor (PAI-1) with an IC₅₀ of 6.95 μM.

HY-15253

Tiplaxtinin Maximum Cited Publications 6 Publications Verification PAI-039; Tiplasinin	PAI-1 Apoptosis	Metabolic Disease Cancer
Tiplaxtinin is a selective and orally efficacious inhibitor of plasminogen activator inhibitor-1 (PAI-1) with IC₅₀ of 2.7 μM ^[1].

HY-N0518

Toddalolactone 1 Publications Verification	PAI-1	Cardiovascular Disease
Toddalolactone, a main component of Toddalia asiatica, inhibits the activity of recombinant human plasminogen activator inhibitor-1 (PAI-1), with an IC₅₀ value of 37.31 μM ^[1].

HY-122714

SK-216	PAI-1	Cancer
SK-216 is a plasminogen activator inhibitor-1 (PAI-1) inhibitor that acts as an anti-metastatic agent for human osteosarcoma and inhibits lung metastasis of human osteosarcoma ^[1].

HY-N1504

Loureirin B	PAI-1 Potassium Channel ERK JNK	Metabolic Disease
Loureirin B, a flavonoid extracted from Dracaena cochinchinensis, is an inhibitor of plasminogen activator inhibitor-1 *(PAI-1), with an IC₅₀ of 26.10 μM; Loureirin B also inhibits K_ATP, the phosphorylation of ERK* and JNK, and has anti-diabetic activity.

HY-116868

Anecortave acetate Anecortave	PAI-1	Cardiovascular Disease
Anecortave acetate is a potent ocular angiostatic agent. Anecortave acetate inhibits neovascularization which is induced by many different angiogenic factors, and increases plasminogen activator inhibitor-1 (PAI-1) mRNA expression. Anecortave acetate can be used to research ocular neovascular diseases ^[1] .

HY-119160

TM5007	PAI-1	Inflammation/Immunology Cancer
TM5007 is a poent and orally active inhibitor of plasminogen activator inhibitor-1 (PAI-1) with an IC₅₀ of 29 μM. TM5007 enhance fibrinolysis activity and inhibits coagulation. TM5007 also prevents the fibrotic process initiated by bleomycin in mouse lung ^[1].

HY-B0111

Drospirenone Dihydrospirorenone	Progesterone Receptor Androgen Receptor	Endocrinology Cancer
Drospirenone (Dihydrospirorenone) is an orally active fourth-generation progestin that interacts with the progesterone receptor (PR) and androgen receptor (AR). Drospirenone significantly decreases both plasminogen activator inhibitor-1 (PAI-1) and tissue plasminogen activator (tPA) via the AR. Drospirenone can produce DNA damage in bone marrow cells of female mice. ^[1] .

HY-101761

TM5441 Maximum Cited Publications 6 Publications Verification	PAI-1 Apoptosis	Cancer
TM5441 is an orally bioavailable inhibitor of plasminogen activator inhibitor-1 (PAI-1), has IC₅₀ values between 13.9 and 51.1 μM and induces intrinsic apoptosis in several human cancer cell lines. TM5441 attenuates Nω-nitro-l-arginine methyl ester-induced cardiac hypertension and vascular senescence ^[1] .

HY-115669

Pentachloropseudilin Antibiotic A 15104 Y; PClP	Myosin TGF-β Receptor	Cancer
Pentachloropseudilin (Antibiotic A 15104 Y; PClP) is a reversible and allosteric potent inhibitor of *Myo1s* (class 1 myosins) with IC₅₀s range from 1 to 5 μM for mammalian class-1 myosins and greater than 90 μM for class-2 and class-5 myosins. Pentachloropseudilin is a potent inhibitor of transforming growth factor-β (TGF-β)-stimulated signaling, with an IC₅₀ of 0.1 to 0.2 μM for TGF-β ^[1] .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0518

Toddalolactone 1 Publications Verification	Cardiovascular Disease Toddalia asiatica (L.) Lam. Classification of Application Fields Source classification Rutaceae Coumarins Phenylpropanoids Plants Disease Research Fields	PAI-1
Toddalolactone, a main component of Toddalia asiatica, inhibits the activity of recombinant human plasminogen activator inhibitor-1 (PAI-1), with an IC₅₀ value of 37.31 μM ^[1].

HY-N1504

Loureirin B	Dracaena cochinchinensis (Lour.) S. C. Chen Structural Classification Monophenols Flavonoids Classification of Application Fields Source classification Phenols Metabolic Disease Agavaceae Plants Dihydrochalcones Disease Research Fields	PAI-1 Potassium Channel ERK JNK
Loureirin B, a flavonoid extracted from Dracaena cochinchinensis, is an inhibitor of plasminogen activator inhibitor-1 *(PAI-1), with an IC₅₀ of 26.10 μM; Loureirin B also inhibits K_ATP, the phosphorylation of ERK* and JNK, and has anti-diabetic activity.

HY-N10227

Geodin	Human Gut Microbiota Metabolites Monophenols Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Phenols Endogenous metabolite Disease Research Fields Inflammation/Immunology	PAI-1 Antibiotic
Geodin, a fungal metabolite, shows antibacterial activity. Geodin also is an inhibitor of plasminogen activator inhibitor- 1 (PAI-1) ^[1].

Recombinant Proteins Recommended:

PAI-1

Species:	Human (1) Mouse (1) Rat (2)
Tag:	His (3) Fc (1)
Source:	HEK293 (4)

Cat. No.	Compare	Product Name	Species	Source

HY-P71133

	Serpin E1 Protein, Mouse (N172S, R253G, HEK293, His) Plasminogen activator inhibitor 1; Endothelial plasminogen activator inhibitor; Serpin E1; Mr1; PAI1; Planh1;	Mouse	HEK293
	Serpin E1 Protein, a serine protease inhibitor, regulates TMPRSS7 and is a primary inhibitor for tissue-type plasminogen activator (PLAT) and urokinase-type plasminogen activator (PLAU). It crucially down-regulates fibrinolysis, controlling blood clot degradation. As a PLAU inhibitor, Serpin E1 regulates cell adhesion and spreading, contributing to keratinocyte migration in cutaneous injury repair. Beyond protease inhibition, it regulates cell migration, influencing senescence, alveolar type 2 cells' senescence in the lung, cementogenic differentiation in periodontal ligament stem cells, and odontoblast differentiation in odontogenesis. Serpin E1 forms a heterodimer with TMPRSS7, interacts with proteins like VTN, PPP1CB, SORL1, LRP1, and PLAUR, emphasizing its multifaceted regulatory role. Serpin E1 Protein, Mouse (N172S, R253G, HEK293, His) is the recombinant mouse-derived Serpin E1 protein, expressed by HEK293 , with C-6*His labeled tag and N172S, R253G mutation. The total length of Serpin E1 Protein, Mouse (N172S, R253G, HEK293, His) is 380 a.a., with molecular weight of ~48.54 kDa.

HY-P73655

	Serpin E1 Protein, Rat (HEK293, His) Plasminogen activator inhibitor 1; PAI-1; Serpin E1; Serpine1; Planh1	Rat	HEK293
	Serpin E1 Protein, Rat (HEK293, His) is one important member of the serine proteinase inhibitor E superfamily that plays a crucial role in the fibrinolytic system. The Serpin E1 protein is a single-chain glycoprotein composed of 379 amino acids. The active site of the protein is Arg346-Met347. SERPINE1 encodes plasminogen activator inhibitor type 1 (PAI-1), which serves as the primary inhibitor of urokinase plasminogen activator (uPA) and tissue-type plasminogen activator (tPA). The Serpin E1 protein can quickly inhibit the formation of plasmin. Serpin E1 can be transcribed through several signaling cascades, including pro-fibrogenic and pro-inflammatory pathways. Serpin E1 is a serine proteinase inhibitor, serves as an important regulator of extracellular matrix remodeling. Serpin E1 Protein, Rat (HEK293, His) is the recombinant rat-derived Serpin E1 protein, expressed by HEK293 , with C-His, C-10*His labeled tag. The total length of Serpin E1 Protein, Rat (HEK293, His) is 379 a.a., with molecular weight of 48-60 kDa.

HY-P71077

	Serpin E1 Protein, Human (HEK293, His) Plasminogen Activator Inhibitor 1; PAI; PAI-1; Endothelial Plasminogen Activator Inhibitor; Serpin E1; SERPINE1; PAI1; PLANH1	Human	HEK293
	Serpin E1 is a serine protease inhibitor that regulates various cellular processes by inhibiting TMPRSS7, tissue-type plasminogen activator (PLAT), and urokinase-type plasminogen activator (PLAU). During fibrinolysis, it downregulates PLAT to control thrombus degradation and acts as a PLAU inhibitor to regulate cell adhesion. Serpin E1 Protein, Human (HEK293, His) is the recombinant human-derived Serpin E1 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Serpin E1 Protein, Human (HEK293, His) is 379 a.a., with molecular weight of ~44-51 kDa.

HY-P73336

	Serpin E1 Protein, Rat (HEK293, Fc) Plasminogen activator inhibitor 1; PAI-1; Serpin E1; Serpine1; Planh1	Rat	HEK293
	Serpin E1 is a serine protease inhibitor that regulates TMPRSS7 and inhibits tissue-type plasminogen activator (PLAT) and urokinase-type plasminogen activator (PLAU). It can significantly downregulate fibrinolysis and control thrombus degradation. Serpin E1 Protein, Rat (HEK293, Fc) is the recombinant rat-derived Serpin E1 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of Serpin E1 Protein, Rat (HEK293, Fc) is 402 a.a., with molecular weight of ~70 kDa.


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HY-P81779

PAI1 Antibody (YA1524)

SERPINE1; PAI1; PLANH1; Plasminogen activator inhibitor 1; PAI; PAI-1; Endothelial plasminogen activator inhibitor; Serpin E1
WB Human, Mouse

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