Search Result

Isoforms Recommended:	PARP PARP14

Results for "

PARP14

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (1) PARP (7) Small Interfering RNA (siRNA) (3)
By Research Areas:	Cancer (5) Inflammation/Immunology (3)

Inhibitors & Agonists

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

PARP14 inhibitor H10	PARP Apoptosis	Cancer
PARP14 inhibitor H10, compound H 10, is a selective inhibitor against *PARP14* (IC₅₀=490 nM), over other PARPs (≈24 fold over PARP1). PARP14 inhibitor H10 induces caspase-3/7-mediated cell apoptosis .

RBN-3143	PARP	Inflammation/Immunology
RBN-3143 is a potent and NAD+-competitive catalytic *PARP14* inhibitor with an IC₅₀ value of 4 nM. RBN-3143 inhibits PARP14-mediated ADP-ribosylation and stabilizes PARP14 in cell lines. RBN-3143 can be used in research of lung inflammation .

PARP14 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)
PARP14 Human Pre-designed siRNA Set A contains three designed siRNAs for PARP14 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

PARP14 Human Pre-designed siRNA Set A PARP14 Human Pre-designed siRNA Set A

Parp14 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Parp14 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Parp14 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Parp14 Mouse Pre-designed siRNA Set A Parp14 Mouse Pre-designed siRNA Set A

Parp14 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Parp14 Rat Pre-designed siRNA Set A contains three designed siRNAs for Parp14 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Parp14 Rat Pre-designed siRNA Set A Parp14 Rat Pre-designed siRNA Set A

RBN012759 4 Publications Verification	PARP	Inflammation/Immunology Cancer
RBN012759 is a potent, selective and orally active inhibitor of *PARP14, with an IC₅₀* of <3 nM. RBN012759 displays 300-fold selectivity over the monoPARPs and 1000-fold selectivity over the polyPARPs. RBN012759 decreases pro-tumor macrophage function and elicits inflammatory responses in tumor explants .

GeA-69	PARP	Cancer
GeA-69 is a selective, allosteric inhibitor of poly-adenosine-diphosphate-ribose polymerase 14 (PARP14) targeting macrodomain 2 (MD2), with a K_d value of 2.1 µM. GeA-69 involves in DNA damage repair mechanisms and prevents recruitment of PARP14 MD2 to sites of laser-induced DNA damage .

ART-IN-1	PARP	Cancer
ART-IN-1 (compound 7) is a selective *PARP* inhibitor with IC₅₀s of 19, 22, 2.4, >100, 1.1 µM for PARP2, TNKS2, PARP10, PARP14, PARP15, respectively .

OUL232	PARP	Cancer
OUL232 is a potent inhibitor of mono-ARTs PARP7, PARP10, PARP11, PARP12, PARP14, and *PARP15. OUL232 is the most potent PARP10* inhibitor described to date (IC₅₀=7.8 nM), as well as the first *PARP12* inhibitor ever reported .

*ARTD10/PARP10-IN-1*	PARP	Inflammation/Immunology
ARTD10/PARP10-IN-1 (compound 23) is a potent and non-selective *PARP* inhibitor, targeting to mono-ADP-ribosyltransferases *ARTD7/PARP15, ARTD8/PARP14, ARTD10/PARP10* and poly(ADP-ribose) polymerase-1 (ARTD1/PARP1) with IC₅₀s of 1.7 μM, 1.6 μM, 0.8 μM, and 4.4 μM, respectively .

Cat. No.	Compare	Product Name	Species	Source

	PARP14 Protein, Human PARP14; Protein mono-ADP-ribosyltransferase PARP14; ADP-ribosyltransferase diphtheria toxin-like 8; ARTD8; B aggressive lymphoma protein 2; Poly [ADP-ribose] polymerase 14; PARP-14	Human	E. coli
	The PARP14 protein is an ADP-ribosyltransferase that uniquely mono-ADP-ribosylates glutamic acid residues on target proteins such as STAT1 and STAT6, unlike PARP1 and PARP2. It catalyzes STAT1 mono-ADP ribosylation at “Glu-657” and “Glu-705”, reduces STAT1 phosphorylation and inhibits the production of pro-inflammatory cytokines in macrophages following IFNG stimulation. PARP14 Protein, Human is the recombinant human-derived PARP14 protein, expressed by E. coli , with tag free. The total length of PARP14 Protein, Human is 180 a.a., .

	PARP14 Protein, Human (His, Strep) PARP14; Protein mono-ADP-ribosyltransferase PARP14; ADP-ribosyltransferase diphtheria toxin-like 8; ARTD8; B aggressive lymphoma protein 2; Poly [ADP-ribose] polymerase 14; PARP-14	Human	E. coli
	The PARP14 protein is an ADP-ribosyltransferase that uniquely mono-ADP-ribosylates glutamic acid residues on target proteins such as STAT1 and STAT6, unlike PARP1 and PARP2. It catalyzes STAT1 mono-ADP ribosylation at “Glu-657” and “Glu-705”, reduces STAT1 phosphorylation and inhibits the production of pro-inflammatory cytokines in macrophages following IFNG stimulation. PARP14 Protein, Human (His, Strep) is the recombinant human-derived PARP14 protein, expressed by E. coli , with N-Strep, N-8*His labeled tag. The total length of PARP14 Protein, Human (His, Strep) is 180 a.a., .


Products	In-stock - + Add to Cart
Cat. No.
Species
Source
Tag
Accession
Gene ID
Molecular Weight
Purity
Endotoxin Level
Biological Activity
Appearance
Formulation
Storage & Stability
Shipping
Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

Inquiry Online

Your information is safe with us. * Required Fields.

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks

Inquiry Online

Inquiry Information

Name
Email *

	Sorry, but the email address you supplied was invalid.