Search Result

Results for "

PC12

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (3) Adrenergic Receptor (2) Akt (2) Amino Acid Derivatives (1) Amyloid-β (10) Apoptosis (6) Autophagy (3) Bacterial (2) Calmodulin (1) Caspase (2) Cholinesterase (ChE) (8) COMT (1) COX (2) Dopamine Receptor (6) E1/E2/E3 Enzyme (2) Endogenous Metabolite (1) ERK (2) Fluorescent Dye (3) HDAC (2) HIV (1) iGluR (1) Interleukin Related (3) Isotope-Labeled Compounds (1) JNK (2) Keap1-Nrf2 (2) Mitophagy (2) Monoamine Oxidase (4) nAChR (1) p38 MAPK (2) p62 (2) PGE synthase (2) Potassium Channel (1) Prostaglandin Receptor (1) Reactive Oxygen Species (6) SGLT (1) Sigma Receptor (6) Tau Protein (1) TNF Receptor (1)
By Research Areas:	Cancer (7) Cardiovascular Disease (1) Infection (3) Inflammation/Immunology (7) Metabolic Disease (1) Neurological Disease (61)

By Targets:

5-HT Receptor (3)

Adrenergic Receptor (2)

Akt (2)

Amino Acid Derivatives (1)

Amyloid-β (10)

Apoptosis (6)

Autophagy (3)

Bacterial (2)

Calmodulin (1)

Caspase (2)

Cholinesterase (ChE) (8)

COMT (1)

COX (2)

Dopamine Receptor (6)

E1/E2/E3 Enzyme (2)

Endogenous Metabolite (1)

ERK (2)

Fluorescent Dye (3)

HDAC (2)

HIV (1)

iGluR (1)

Interleukin Related (3)

Isotope-Labeled Compounds (1)

JNK (2)

Keap1-Nrf2 (2)

Mitophagy (2)

Monoamine Oxidase (4)

nAChR (1)

p38 MAPK (2)

p62 (2)

PGE synthase (2)

Potassium Channel (1)

Prostaglandin Receptor (1)

Reactive Oxygen Species (6)

SGLT (1)

Sigma Receptor (6)

Tau Protein (1)

TNF Receptor (1)

By Research Areas:

Cancer (7)

Cardiovascular Disease (1)

Infection (3)

Inflammation/Immunology (7)

Metabolic Disease (1)

Neurological Disease (61)

Inhibitors & Agonists

Fluorescent Dye

Peptides

MCE Kits

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N8103

Heishuixiecaoline A	Amyloid-β	Neurological Disease
Heishuixiecaoline A is a germacrane-type sesquiterpenoid. Heishuixiecaoline A shows protective effect on the neurotoxicity of PC12 cells induced by Aβ_25-35 .

HY-N9085

Neuchromenin	Bacterial	Neurological Disease
Neuchromenin is a microbial melabolite that can be isolated from the culture broth of Eupenicillium javanicum var. meloforme PFll81. Neuchromenin induces neurite outgrowth of PC12 cells .

HY-N3563

Celaphanol A	Others	Neurological Disease
Celaphanol A is a diterpene that can be isolated from the root bark of Celastrus orbiculatus. Celaphanol A shows neuroprotective effect against a hydrogen peroxide-induced cytotoxicity in PC12 cells .

HY-N11001

Erinacine U	Others	Neurological Disease
Erinacine U is a cyanogen diterpene isolated from Hericium erinaceus, which has neurotrophic activity and has obvious neurite growth-promoting effect on PC12 cells .

HY-N10325

Sarbronine M

Others Others

Scabronine M is a novel inhibitor of NGF-induced neurite outgrowth from PC12 cells.

Sarbronine M	Others	Others
Scabronine M is a novel inhibitor of NGF-induced neurite outgrowth from PC12 cells.

HY-N12225

Isoasiaticoside	Others	Neurological Disease
Isoasiaticoside is a pentacyclic triterpene saponin that can be isolated from Centella asiatica. Isoasiaticoside has potential neuroprotective effects in the 6-OHDA (HY-B1081)-induced PC12 cell model .

HY-117517

NG-012	Others	Cancer
NG-012, potentiator of nerve growth factor (NGF), were isolated from the culture broth of Penicillium verruculosum F-4542. NG-012 potentiates the neurite outgrowth induced by NGF in rat pheochromocytoma cell line (PC12) .

HY-110166

PD 90780 1 Publications Verification	Others	Neurological Disease
PD 90780 is a non peptide antagonist of nerve growth factor (NGF). PD 90780 interacts with NGF, prevents NGF binds with p75 ^NTR. PD 90780 inhibits NGF-p75 ^NTR interaction with IC₅₀s of 23.1 and 1.8 µM in PC12 cells and PC12 ^nnr5 cells, respectively .

HY-N4285

Negletein 5,6-Dihydroxy-7-methoxyflavone	TNF Receptor Interleukin Related	Neurological Disease Inflammation/Immunology
Negletein is a neuroprotectant enhances the action of nerve growth factor and induces neurite outgrowth in PC12 cells. Negletein shows promising anti-inflammatory activity via inhibition of TNF-α and IL-1β with IC₅₀ values of 16.4 and 10.8 μM, respectively .

HY-N12123

Peimisine 3-O-β-D-glucopyranoside	Others	Others
Peimisine 3-O-β-D-glucopyranoside (Compound 1) is a steroid alkaloid. Peimisine 3-O-β-D-glucopyranoside can be isolated and purified from natural Fritillaria unibracteata. Peimisine 3-O-β-D-glucopyranoside shows moderate protective effect on rotenone-induced neurotoxicity of PC12 cell line .

HY-N2099

Onjisaponin B	Autophagy	Neurological Disease
Onjisaponin B is a natural product derived from Polygala tenuifolia. Onjisaponin B enhances autophagy and accelerates the degradation of mutant α-synuclein and huntingtin in PC-12 cells, and exbibits potential therapeutic effects on Parkinson disease and Huntington disease .

HY-N10384

AChE-IN-17	Cholinesterase (ChE)	Neurological Disease
AChE-IN-17 (compound 1) is a potent AChE inhibitor with an IC₅₀ value of 28.98 μM. AChE-IN-17 can significantly prevent H₂O₂-induced PC12 cell death, exhibiting excellent neuroprotective effect. AChE-IN-17 can be used for researching neurodegenerative diseases (NDs) .

HY-N12001

6-Epiagarotetrol	Others	Neurological Disease
6-Epiagarotetrol is a neuroprotective agent can be extracted from Aquilaria sinensis. 6-Epiagarotetrol has a protective effect on corticosterone-induced PC12 cell damage .

HY-N3550

Catalponol	Others	Cancer
Catalponol is a naphthoquinone derivative. Catalponol enhances dopamine biosynthesis by inducing tyrosine hydroxylase activity. Catalponol also increases the levels of cAMP and tyrosine hydroxylase phosphorylation in PC12 cells .

HY-128536

KMG-104AM	Fluorescent Dye	Others
KMG-104AM, a selective fluorescein-derived magnesium fluorescent membrane-permeable probe, successfully incorporates into PC12 cells and is used to Intracellular 3D Mg ²⁺ Imaging .

HY-N5021

Anhydrosafflor yellow B AHSYB	Others	Neurological Disease
Anhydrosafflor yellow B (AHSYB) is a quinochalcone C-glycoside isolated from Carthamus tinctorius. Anhydrosafflor yellow B inhibits ADP-induced platelet aggregation, exhibits significant anti-oxidative effects in vitro, and possesses certain activity against H₂O₂-induced cytotoxicity in cultured PC12 cells and primary neuronal cells .

HY-133101

14-Norpseurotin	Others	Cancer
14-Norpseurotin is a compound isolated from the culture of Aspergillus fumigatus. 14-Norpseurotin significantly induces neurite outgrowth of rat pheochromocytoma cells (PC12) at a 10.0 microM concentration .

HY-136480

Chrysamine G	Amyloid-β	Neurological Disease
Chrysamine G, a carboxylic acid analogue of Congo Red, can be used as a probe of amyloid deposition in Alzheimer's disease. Chrysamine G also can inhibit Aβ-induced toxicity in PC12 cells .

HY-162330

HDAC6-IN-36	HDAC	Neurological Disease
HDAC6-IN-36 (compound 11d) is an inhibitor of HDAC6 with IC₅₀ value of 8.64 nM. HDAC6-IN-36 induces neurite outgrowth of PC12 cells without producing toxic effects.

HY-P5754

TAT-NEP1-40	Apoptosis	Neurological Disease
TAT-NEP1-40 is a BBB-penatrable peptide. TAT-NEP1-40 protects PC12 cells against oxygen and glucose deprivation (OGD), and promotes neurite outgrowth. TAT-NEP1-40 also improves ischemia-induced neurologic outcomes by inhibiting cell apoptosis in ischemic brains. TAT-NEP1-40 can be used for research of CNS injuries, such as axonal regeneration and functional recovery after stroke .

HY-155049

NMDA receptor antagonist 6	iGluR	Neurological Disease
NMDA receptor antagonist 6 (compound 13b) is an antagonist of NMDA receptor, targeting to the glycine binding site. NMDA receptor antagonist 6 shows cytoneuroprotective potency, and protects PC12 cells against NMDA-induced injury and cell apoptosis .

HY-P5876

Proadrenomedullin (N-20) (bovine, porcine) ProADM N20(bovine, porcine); PAMP-20(bovine, porcine)	nAChR	Neurological Disease
Proadrenomedullin (N-20) (ProADM N20) (bovine, porcine) is a potent and noncompetitive hypotensive and catecholamine release-inhibitory peptide released from chromaffin cells. Proadrenomedullin (N-20) (bovine, porcine) inhibits catecholamine secretion with an IC₅₀ of 350 nM in PC12 pheochromocytoma cells. Proadrenomedullin (N-20) (bovine, porcine) also blocks (EC₅₀≈270 nM) nicotinic cholinergic agonist desensitization of catecholamine release, as well as desensitization of nicotinic signal transduction ( ²²Na ⁺ uptake) .

HY-P5754A

TAT-NEP1-40 TFA	Apoptosis	Neurological Disease
TAT-NEP1-40 TFA is a BBB-penatrable peptide. TAT-NEP1-40 TFA protects PC12 cells against oxygen and glucose deprivation (OGD), and promotes neurite outgrowth. TAT-NEP1-40 TFA also improves ischemia-induced neurologic outcomes by inhibiting cell apoptosis in ischemic brains. TAT-NEP1-40 TFA can be used for research of CNS injuries, such as axonal regeneration and functional recovery after stroke .

HY-N2180

Pinoresinol dimethyl ether (+)-Eudesmin
Pinoresinol dimethyl ether ((+)-Eudesmin) is a non-phenolic furofuran lignan isolated from Magnolia biondii with neuritogenic activity. Pinoresinol dimethyl ether ((+)-Eudesmin) can induce neuritis outgrowth from PC12 cells by stimulating up-stream MAPK, PKC and PKA pathways .

HY-P5754B

TAT-NEP1-40 acetate	Apoptosis	Neurological Disease
TAT-NEP1-40 acetate is a therapeutic candidate for axonal regeneration and functional recovery after stroke. TAT-NEP1-40 acetate can protect PC12 cells against oxygen and glucose deprivation (OGD) and promote neurite outgrowth. TAT-NEP1-40 acetate protects the brain against ischemia/reperfusion injury through inhibition of neuronal apoptosis. TAT-NEP1-40 acetate can be efficiently delivered into the rat brains .

HY-N3562

Cedrin	Reactive Oxygen Species	Neurological Disease
Cedrin is a natural flavonoid that can be found in Cedrus deodara. Cedrin protects PC12 cells against neurotoxicity induced by Aβ1-42. Cedrin can reduce reactive oxygen species overproduction, increase the activity of superoxide dismutase and decrease malondialdehyde content .

HY-125125

Danshenxinkun D	Others	Neurological Disease
Danshenxinkun D is an anti-Alzheimer's disease (AD) candidate. Danshenxinkun D can significantly reverse the expression of PSEN1 and DRD2 mRNA in H₂O₂ treated PC12 cells. Danshenxinkun D can be used in the study of anti-Alzheimer's disease product candidate [1].

HY-N9257

8-Hydroxypinoresinol4,4'-di-O-β-D-glucopyranoside	Others	Neurological Disease
8-Hydroxypinoresinol4,4'-di-O-β-D-glucopyranoside (Compound 7) is a compound derived from roots and rhizomes. 8-Hydroxypinoresinol4,4'-di-O-β-D-glucopyranoside could prevent neurotoxicity in PC12 cells .

HY-17406S

Tolcapone-d7 Ro 40-7592 d₇	Isotope-Labeled Compounds COMT Amyloid-β	Neurological Disease
Tolcapone-d₇ is a deuterium labeled Tolcapone. Tolcapone is a selective, potent and orally active COMT inhibitor. Tolcapone is also a potent inhibitor of α-syn and Aβ42 oligomerization and fibrillogenesis and protect against extracellular toxicity induced by the aggregation of both proteins in PC12 cells[1][2].

HY-N3489

Isodihydrofutoquinol B	Others	Neurological Disease
Isodihydrofutoquinol B (compound 9), an active compound, can be isolated from the stems of Piper kadsura (Choisy) Ohwi. Isodihydrofutoquinol B has A neuroprotective effect on Aβ25-35-induced PC12 cell damage with E₅₀ values of 3.06-29.3μM .

HY-151431

Nrf2/HO-1 activator 2	Keap1-Nrf2 Reactive Oxygen Species ERK Akt JNK	Neurological Disease
Nrf2/HO-1 activator 2 (compound 13m), difluoro-substituted derivative, is a potent Nrf2/HO-1 activator. Nrf2/HO-1 activator 2 has neuroprotective and antioxidant effects through the Nrf2/HO-1 pathway mediated by phosphorylation of ERK1/2, JNK, or Akt in PC12 cells. Nrf2/HO-1 activator 2 can be used in the research of Parkinson's disease (PD) .

HY-P5156

BDS-I	Potassium Channel	Neurological Disease
BDS-I known as blood depressing substance, is a marine toxin which can be extracted from Anemonia sulcata. BDS-I is a specific inhibitor of Potassium Channel, targeting to Kv3.4. BDS-I inhibits Aβ1-42-induced enhancement of KV3.4 activity, caspase-3 activation, and abnormal nuclear morphology of NGF-differentiated PC-12 cells. BDS-I reverts the Aβ peptide-induced cell death .

HY-N4192

Toringin	Others	Cardiovascular Disease Cancer
Toringin, a bioflavonoid, is isolated from the bark of Docyniopsis tschonoski. Toringin progressively decreases not only the cis-effect of the expanded CTG repeats but cytotoxicity as well. Exposure to isosakuranetin, Toringin rescues PC12 neuronal cells. Flavonoids are efficacious for ameliorating the RNA gain of function caused by expanded CTG repeats, and have various biological activities and beneficial actions against cancers, coronary heart disease, among other pathologies .

HY-157394

eeAChE/eqBuChE-IN-1	Cholinesterase (ChE)	Inflammation/Immunology
eeAChE/eqBuChE-IN-1 (compound 3F) is a reversible dual eeAChE/eqBuChE inhibitor with IC₅₀s of 1.3?μM and 0.81?μM, respectively. eeAChE/eqBuChE-IN-1 exhibits anti-inflammatory activity. eeAChE/eqBuChE-IN-1 also shows neuroprotective effect on Aβ25-35-induced PC12 cell injury .

HY-150563

Neuroinflammatory-IN-2	Monoamine Oxidase Amyloid-β	Neurological Disease Inflammation/Immunology
Neuroinflammatory-IN-2 is a potent anti-neuroinflammatory agent with an IC₅₀ value of 10.30 μM for MAO-B, and 96.33% inhibition of Aβ_1-42 aggregation at 25 μM. Neuroinflammatory-IN-2 has neuroprotective activity in H₂O₂-induced PC-12 cell injury. Neuroinflammatory-IN-2 also has biometal chelating abilities, antioxidant activity, anti-neuroinflammatory activity and appropriate BBB permeability. Neuroinflammatory-IN-2 can be used for researching Alzheimer’s disease .

HY-157437

AChE/BChE-IN-16	Cholinesterase (ChE) Reactive Oxygen Species	Neurological Disease Inflammation/Immunology
AChE/BChE-IN-16 (compound C7) is a potent cholinesterase (ChE) inhibitor with IC₅₀s of 30 nM and 48 nM for human acetylcholinesterase (hAChE) and human butyrylcholinesterase (hBChE), respectively. AChE/BChE-IN-16 exhibits a remarkable capacity to safeguard PC12 cells against H₂O₂-induced apoptosis and effectively suppresses the production of reactive oxygen species (ROS) .

HY-N0615

Notoginsenoside R1 1 Publications Verification Sanchinoside R1; Sanqi glucoside R1	Amyloid-β Apoptosis	Others
Notoginsenoside R1 (Sanchinoside R1), a saponin, is isolated from P. notoginseng. Notoginsenoside R1 exhibits anti-oxidation, anti-inflammatory, anti-angiogenic, and anti-apoptosis activities. Notoginsenoside R1 provides cardioprotection against ischemia/reperfusion (I/R) injury. Notoginsenoside R1 also provides neuroprotection in H₂O₂-induced oxidative damage in PC12 cells .

HY-105118A

Zaldaride maleate CGS-9343B; KW 5617	Calmodulin	Neurological Disease Metabolic Disease Inflammation/Immunology
Zaldaride maleate (CGS-9343B) is a potent, orally active and selective inhibitor of calmodulin. Zaldaride maleate (CGS-9343B) inhibits CaM (calmodulin)-stimulated cAMP phosphodiesterase activity, with an IC₅₀ of 3.3 nM . Zaldaride maleate (CGS-9343B) prevents estrogen-induced transcription activation by ER, reversibly blocks voltage-activated Na ⁺, Ca ²⁺ and K ⁺ currents in PC12 cells and inhibits nAChR .

HY-N3938

Gelsemiol	Others	Neurological Disease
Gelsemiol is the main active ingredient in Verbena littoralis H. B. K.. Gelsemiol enhanced nerve growth factor (NGF) -induced axonal elongation in PC12D cells .

HY-N12170

Kissoone C	Others	Neurological Disease
Kissoone C (compound 3) is a three-membered ring sesquiterpene isolated from valerian root. Kissoone C can enhance the activity of nerve growth factor (NGF)-mediated neurite outgrowth in PC12D cells .

HY-N3928

Garciniaxanthone E	Others	Neurological Disease
Garciniaxanthone E is a xanthone compound. Garciniaxanthone E significantly enhances cellular nerve growth factor (NGF)-mediated neurite outgrowth in PC12D cells. Garciniaxanthone E contributes to basic research and medicinal development in neurodegenerative diseases .

HY-149803

S1R agonist 1	Sigma Receptor	Neurological Disease
S1R agonist 1 (Compound 6b) is a selective S1R agonist with K_is of 0.93 nM and 72 nM for S1R and S2R, respectively. S1R agonist 1 exhibits neuroprotection against ROS and NMDA-induced neurotoxicity .

HY-149804

S1R agonist 2	Sigma Receptor	Neurological Disease
S1R agonist 2 (Compound 8b) is a selective S1R agonist with K_is of 1.1 nM and 88 nM for S1R and S2R, respectively. S1R agonist 2 exhibits neuroprotection against ROS and NMDA-induced neurotoxicity .

HY-131640

1,2-Didecanoyl PC 1,2-Didecanoyl-sn-glycero-3-phosphocholine	Others	Others
1,2-Didecanoyl PC (1,2-Didecanoyl-sn-glycero-3-phosphocholine) is a phosphocholine that can be introduced into single-chain mean field theory as a coarse-grained model of saturated phospholipids. The 1,2-Didecanoyl PC model can be used to estimate the free energy of compressive or tensile bilayers in stacks or multilayers and gives a reasonable estimate of the free energy .

HY-149803A

S1R agonist 1 hydrochloride	Sigma Receptor	Neurological Disease
S1R agonist 1 (Compound 6b) hydrochloride is a selective S1R agonist with K_is of 0.93 nM and 72 nM for S1R and S2R, respectively. S1R agonist 1 hydrochloride exhibits neuroprotection against ROS and NMDA-induced neurotoxicity .

HY-149804A

S1R agonist 2 hydrochloride	Sigma Receptor	Neurological Disease
S1R agonist 2 (Compound 8b) hydrochloride is a selective S1R agonist with K_is of 1.1 nM and 88 nM for S1R and S2R, respectively. S1R agonist 2 hydrochloride exhibits neuroprotection against ROS and NMDA-induced neurotoxicity .

HY-146142

AChE/BuChE-IN-2	Cholinesterase (ChE) Amyloid-β	Neurological Disease
AChE/BuChE-IN-2 (Compound 5f) is an orally active AChE and BuChE inhibitor with IC₅₀ values of 0.72 μM and 0.16 μM, respectively. AChE/BuChE-IN-2 shows a non-competitive inhibition with AChE and shows potent self-induced β-amyloid (Aβ) aggregation inhibition with an IC₅₀ of 62.52 μM. AChE/BuChE-IN-2 can cross the BBB .

HY-124366

Slingshot inhibitor D3	Others	Infection Cancer
Slingshot inhibitor D3 is a potent, selective, reversible and competitive inhibitor of Slingshot. The IC₅₀ value for Slingshot 1 is 3 μM and the K_i value for Slingshot 2 is 3.9 μM. Slingshot inhibitor D3 has similar inhibitory activities toward both Slingshot 1 and Slingshot 2 .

HY-147980

Aβ-IN-5	Amyloid-β Cholinesterase (ChE)	Neurological Disease
Aβ-IN-5 (Compound e12) is an orally active Aβ aggregation inhibitor. Aβ-IN-5 also inhibits AChE and BuChE with IC₅₀ values of 21.29 μM and 1.32 μM, respectively. Aβ-IN-5 shows excellent neuroprotective effects and low neurotoxicity .

HY-P4439

H-Met-Val-OH	Amino Acid Derivatives	Neurological Disease
H-Met-Val-OH is a dipeptide containing free N-terminal methionine. H-Met-Val-OH exhibits activity against cDNA expressing Flavin-containing monooxygenase (FMO) 1 and FMO3. H-Met-Val-OH has potential applications in the growth of neuritis .

Cat. No.	Product Name	Target	Research Area

HY-P1831

Proadrenomedullin (1-20), human ProAM N20, Human; PAMP-20, human	Peptides	Neurological Disease
Proadrenomedullin (1-20), human is a potent hypotensive and catecholamine release–inhibitory peptide released from chromaffin cells with an IC₅₀ of ~350 nM for catecholamine secretion in PC12 pheochromocytoma cells, acting in a noncompetitive manner specifically at the nicotinic cholinergic receptor .