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Isoforms Recommended:	PDE3

Results for "

PDE3A

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (3) Phosphodiesterase (PDE) (13) PKA (3) Small Interfering RNA (siRNA) (3)
By Research Areas:	Cancer (8) Cardiovascular Disease (1) Inflammation/Immunology (1) Metabolic Disease (3) Neurological Disease (4)

Inhibitors & Agonists

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Recombinant Proteins

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-136350

BRD9500	Phosphodiesterase (PDE)	Cancer
BRD9500 is an orally active phosphodiesterases 3 (PDE3) inhibitor with IC₅₀s of 10 and 27 nM for *PDE3A* and *PDE3B*, respectively. Antitumor activity .

HY-RS10216

PDE3A Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)
PDE3A Human Pre-designed siRNA Set A contains three designed siRNAs for PDE3A gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

PDE3A Human Pre-designed siRNA Set A PDE3A Human Pre-designed siRNA Set A

HY-RS10217

Pde3a Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)
Pde3a Mouse Pre-designed siRNA Set A contains three designed siRNAs for Pde3a gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Pde3a Mouse Pre-designed siRNA Set A Pde3a Mouse Pre-designed siRNA Set A

HY-RS10218

Pde3a Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)
Pde3a Rat Pre-designed siRNA Set A contains three designed siRNAs for Pde3a gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Pde3a Rat Pre-designed siRNA Set A Pde3a Rat Pre-designed siRNA Set A

HY-N10149

Nauclefine	Phosphodiesterase (PDE) Apoptosis	Cancer
Nauclefine is an indole alkaloid isolated from Nauclea officinalis. Nauclefine acts as a *PDE3A* modulator to induce cancer cell apoptosis through a PDE3A-SLFN12-dependent death pathway .

HY-W028690

DNMDP 3 Publications Verification	Phosphodiesterase (PDE)	Cancer
DNMDP, a phosphodiesterase 3A (PDE3A) inhibitor, is a potent and selective cancer cell cytotoxic agent. DNMDP binding to PDE3A promotes an interaction between PDE3A and Schlafen 12 (SLFN12). DNMDP shows clear cell-selective cytotoxicity .

HY-122751

(R)-DNMDP	Phosphodiesterase (PDE)	Cancer
(R)-DNMDP is a potent and selective cancer cell cytotoxic agent. (R)-DNMDP, the R-form of DNMDP, binds *PDE3A* directly. (R)-DNMDP has a 500-fold lower EC₅₀ compared to the (S)-enantiomer in HeLa cell line .

HY-100530B

Sp-cAMPS	PKA Phosphodiesterase (PDE)	Neurological Disease Metabolic Disease
Sp-cAMPS, a cAMP analog, is potent activator of cAMP-dependent PKA I and PKA II. Sp-cAMPS is also a potent, competitive phosphodiesterase (PDE3A) inhibitor with a K_i of 47.6 µM. Sp-cAMPS binds the PDE10 GAF domain with an EC₅₀ of 40 μM ^[3].

HY-100530C

Sp-cAMPS sodium salt	PKA Phosphodiesterase (PDE)	Neurological Disease Metabolic Disease
Sp-cAMPS sodium salt, a cAMP analog, is potent activator of cAMP-dependent PKA I and PKA II. Sp-cAMPS sodium salt is also a potent, competitive phosphodiesterase (PDE3A) inhibitor with a K_i of 47.6 µM. Sp-cAMPS sodium salt binds the PDE10 GAF domain with an EC₅₀ of 40 μM ^[3].

HY-110005

Sp-cAMPS triethylamine	PKA Phosphodiesterase (PDE)	Neurological Disease Metabolic Disease
Sp-cAMPS triethylamine, a cAMP analog, is potent activator of cAMP-dependent PKA I and PKA II. Sp-cAMPS triethylamine is also a potent, competitive phosphodiesterase (PDE3A) inhibitor with a K_i of 47.6 µM. Sp-cAMPS triethylamine binds the PDE10 GAF domain with an EC₅₀ of 40 μM ^[3].

HY-145924

BAY 2666605 1 Publications Verification	Phosphodiesterase (PDE)	Cancer
BAY 2666605 is an orally active *PDE3A* and *PDE3B* inhibitor with IC₅₀s of 87 nM and 50 nM, respectively. BAY 2666605 is a *PDE3A-SLFN12* complex inducer (WO2019025562A1; example 135) .

HY-153802

Antitumor agent-100	Apoptosis Phosphodiesterase (PDE)	Cancer
Antitumor agent-100 (compound A6) is an orally available apoptosis inducer and molecular gel targeting *PDE3A*-SLFN12 (IC₅₀: 0.3 μM) with antitumor activity. Antitumor agent-100 binds to the PDE3A enzyme pocket to recruit and stabilize SLFN12, thereby preventing protein translation and leading to apoptosis .

HY-153802A

Antitumor agent-100 hydrochloride	Apoptosis Phosphodiesterase (PDE)	Cancer
Antitumor agent-100 (compound A6) hydrochloride is an orally potent apoptosis inducer and molecular gel targeting *PDE3A*-SLFN12 (IC₅₀: 0.3 μM) with antitumor activity. Antitumor agent-100 hydrochloride binds to the PDE3A enzyme pocket to recruit and stabilize SLFN12, thereby preventing protein translation and leading to apoptosis .

HY-N11965

4'-Methoxyisoagarotetrol	Phosphodiesterase (PDE)	Inflammation/Immunology
4'-Methoxyisoagarotetrol is chromone derivative and shows moderate *PDE?3A* inhibitory activity (IC₅₀=54 μM) .

HY-101312

Cilostamide 1 Publications Verification OPC3689
Cilostamide is a selective and potent *PDE3* inhibitor, with IC₅₀s of 27 nM and 50 nM for PDE3A and PDE3B, respectively, and has antithrombotic and anti-intimal hyperplastic activity.

HY-U00186

K134 OPC33509	Phosphodiesterase (PDE)	Cardiovascular Disease
K134 is a phosphodiesterase 3 (PDE3) inhibitor. The IC₅₀s of K134 toward *PDE3A, PDE3B, PDE5, PDE2 and PDE*4 are 0.1, 0.28, 12.1, >300 and >300 µM, respectively.

HY-136350B

(S)-BRD9500	Others	Cancer
(S)-BRD9500 is the isomer of BRD9500 (HY-136350), and can be used as an experimental control. BRD9500 is an orally active phosphodiesterases 3 (PDE3) inhibitor with IC₅₀s of 10 and 27 nM for *PDE3A* and *PDE3B*, respectively. Antitumor activity .

HY-112831

Osoresnontrine 1 Publications Verification BI-409306	Phosphodiesterase (PDE)	Neurological Disease
Osoresnontrine (BI-409306) is a potent and selective *PDE9A* inhibitor, with an IC₅₀ of 52 nM, and shows weak activity against other PDEs, such as PDE1A (IC₅₀, 1.4 µM), PDE1C (IC₅₀, 1.0 µM), PDE2A, PDE3A, PDE4B, PDE5A, PDE6AB, PDE7A, and PDE10A (IC₅₀ all > 10 μM); Osoresnontrine can be used in the research of memory enhancement in CNS disorders.

Nauclefine	Structural Classification Alkaloids Nauclea officinalis (Pirre ex Pitard) Merr. Source classification Rubiaceae Plants Indole Alkaloids	Phosphodiesterase (PDE) Apoptosis
Nauclefine is an indole alkaloid isolated from Nauclea officinalis. Nauclefine acts as a *PDE3A* modulator to induce cancer cell apoptosis through a PDE3A-SLFN12-dependent death pathway .

4'-Methoxyisoagarotetrol	Structural Classification Natural Products Thymelaeaceae Source classification Plants Aquilaria sinensis (Lour.) Spreng.	Phosphodiesterase (PDE)
4'-Methoxyisoagarotetrol is chromone derivative and shows moderate *PDE?3A* inhibitory activity (IC₅₀=54 μM) .

Cat. No.	Compare	Product Name	Species	Source

HY-P75961

	PDE3A Protein, Human (sf9, His-GST) cGMP-inhibited 3',5'-cyclic phosphodiesterase A; CGI-PDE A; PDE3A	Human	Sf9 insect cells
	PDE3A protein, a cyclic nucleotide phosphodiesterase, targets cAMP, cGMP, and cUMP, crucial in diverse physiological processes. In an E2/17beta-estradiol-induced pro-apoptotic pathway, E2 stabilizes the PDE3A/SLFN12 complex, leading to SLFN12 dephosphorylation and activating its pro-apoptotic ribonuclease activity. This pathway is implicated in tissues with high E2 concentrations, potentially contributing to processes like placenta remodeling. PDE3A Protein, Human (sf9, His-GST) is the recombinant human-derived PDE3A protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag. The total length of PDE3A Protein, Human (sf9, His-GST) is 473 a.a., with molecular weight of ~93 kDa.


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