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Isoforms Recommended:	PDE4

Results for "

PDE4D

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Autophagy (1) Bacterial (1) Cholinesterase (ChE) (1) Endogenous Metabolite (1) HIV (1) mTOR (1) NF-κB (1) Phosphodiesterase (PDE) (22) Small Interfering RNA (siRNA) (1)
By Research Areas:	Cancer (2) Cardiovascular Disease (1) Inflammation/Immunology (13) Neurological Disease (10)

Inhibitors & Agonists

Natural
Products

Recombinant Proteins

Antibodies

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-15444

D159687

Phosphodiesterase (PDE) Neurological Disease

D159687 is a selective PDE4D inhibitor .

D159687	Phosphodiesterase (PDE)	Neurological Disease
D159687 is a selective *PDE4D* inhibitor .

HY-117571

Zatolmilast 2 Publications Verification BPN14770	Phosphodiesterase (PDE)	Neurological Disease
Zatolmilast (BPN14770) is a selective phosphodiesterase 4D (PDE4D) allosteric inhibitor with IC₅₀s of 7.8 nM and 7.4 nM for PDE4D7 and PDE4D3, respectively .

HY-119190

PF-06445974	Phosphodiesterase (PDE)	Neurological Disease
PF-06445974, a promising positron emission tomography (PET) lead, has exquisite potency at *PDE4B* with an IC₅₀ <1 nM. The IC₅₀ values are 36, 4.7 and 17 nM for PDE4D, PDE4A and PDE4C, respectively. PF-06445974 has good selectivity over PDE4D, excellent brain permeability, and a high level of specific binding in the "cold tracer" study .

HY-RS10225

PDE4D Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)
PDE4D Human Pre-designed siRNA Set A contains three designed siRNAs for PDE4D gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

PDE4D Human Pre-designed siRNA Set A PDE4D Human Pre-designed siRNA Set A

HY-154957

mTOR inhibitor-11	mTOR	Neurological Disease
mTOR inhibitor-11 (Compound 9) is a brain-penetrant mTOR inhibitor (IC₅₀: 21 nM for pS6). mTOR inhibitor-11 also inhibits pCHK1 and PDE4D with IC₅₀s of 17.2 and 17.0 μM. mTOR inhibitor-11 can be used for research of CNS disease .

HY-16900

Rolipram Maximum Cited Publications 10 Publications Verification (R,S)-Rolipram; (±)-Rolipram; ZK 62711	Phosphodiesterase (PDE) Bacterial HIV	Neurological Disease Cancer
Rolipram is a selective phosphodiesterases *PDE4* inhibitor with IC₅₀s of 3 nM, 130 nM and 240 nM for PDE4A, PDE4B, and PDE4D, respectively.

HY-16900A

(R)-(-)-Rolipram 2 Publications Verification (R)-Rolipram; (-)-Rolipram	Phosphodiesterase (PDE)	Neurological Disease
(R)-(-)-Rolipram is the R-enantiomer of Rolipram. Rolipram is a selective inhibitor of phosphodiesterases *PDE4* with IC₅₀ of 3 nM, 130 nM and 240 nM for PDE4A, PDE4B, and PDE4D, respectively.

HY-115913

PDE4-IN-6	Phosphodiesterase (PDE)	Inflammation/Immunology
PDE4-IN-6 is a potent, safe and moderately selective *PDE4* inhibitor with IC₅₀s of 0.125 and 0.43 µM for PDE4B and PDE4D, respectively. PDE4-IN-6 can downregulate the expression level of TNF-α and IL-6. PDE4-IN-6 has potent immunomodulatory activity thereby its potential against rheumatoid arthritis. Anti-inflammatory and anti-arthritic effects .

HY-117960

Orismilast LEO-32731	Phosphodiesterase (PDE)	Inflammation/Immunology
Orismilast (LEO-32731) is an orally active and selective *PDE4* inhibitor used for the research of inflammatory diseases. Orismilast demonstrates potent inhibition of PDE4B and PDE4D subtype splice variants .

HY-130262

PDE1-IN-3	Phosphodiesterase (PDE)	Inflammation/Immunology
PDE1-IN-3, compound 4 (WO2019156861), is a selective human phosphodiesterase 1 (PDE1) inhibitor. PDE1-IN-3 inhibits PDE4D and PDE6AB with IC₅₀ values of 23.99 μM and 10 μM, respectively .

HY-131340

LASSBio-1632	Phosphodiesterase (PDE)	Inflammation/Immunology
LASSBio-1632 is a new anti-asthmatic lead candidate associated with selective inhibition of *PDE4A* and *PDE4D* isoenzymes and blockade of airway hyper-reactivity (AHR) and TNF-α production in the lung tissue. LASSBio-1632 (7j) displays high experimental BBB permeability across BBB through passive diffusion .

HY-106003

GSK356278	Phosphodiesterase (PDE)	Neurological Disease Inflammation/Immunology
GSK356278 is a potent, selective, orally bioavailable and brain-penetrant inhibitor of phosphodiesterase 4 (PDE4), with pIC₅₀s of 8.6, 8.8, and 8.7 for human PDE4A, PDE4B, and PDE4D, respectively. GSK356278 has anti-inflammatory activity, and exhibits anxiolytic and cognition-enhancing effects .

HY-115687

PDE4B-IN-2	Phosphodiesterase (PDE)	Inflammation/Immunology
PDE4B-IN-2 is an orally active and selective *PDE4B* inhibitor with an IC₅₀ of 15 nM. PDE4B-IN-2 inhibits PDE4D (IC₅₀=1.7 µM). PDE4B-IN-2 exhibits potent anti-inflammatory effects .

HY-147846

*AChE/PDE4-IN-1*	Cholinesterase (ChE) Phosphodiesterase (PDE)	Neurological Disease
AChE/PDE4-IN-1 (compound 12c) is a potent and selective dual *PDE4/AChE* inhibitor, with IC₅₀s of 0.28 μM and 1.88 μM for AChE and *PDE4D, respectively. AChE/PDE4*-IN-1 exhibits anti-neuroinflammatory effect for the research of Alzheimer's disease .

HY-131707

LEO 39652	Phosphodiesterase (PDE)	Inflammation/Immunology
LEO 39652 is a dual-soft *PDE4* inhibitor with IC₅₀s of 1.2 nM, 1.2 nM, 3.0 nM and 3.8 nM for *PDE4A, PDE4B, PDE4C* and *PDE4D, respectively. LEO 39652 also inhibits TNF-α* with an IC₅₀ value of 6.0 nM. LEO 39652 is used for topical research of Atopic dermatitis (AD) .

HY-N3180

Norbraylin

Phosphodiesterase (PDE) Inflammation/Immunology

Norbraylin, a natural prenylated coumarin, is a PDE4D2 inhibitor with an IC₅₀ value of 7.15 μM .

Norbraylin	Phosphodiesterase (PDE)	Inflammation/Immunology
Norbraylin, a natural prenylated coumarin, is a *PDE4D2* inhibitor with an IC₅₀ value of 7.15 μM .

HY-121037

Eggmanone EGM1	Phosphodiesterase (PDE)	Cancer
Eggmanone (EGM1) is a potent and selective phosphodiesterase 4 (PDE4) antagonist with an IC₅₀ of 72 nM for PDE4D3. Eggmanone shows approximately 40- to 50-fold selective for PDE4D3 over other PDEs. Eggmanone exerts its Hh-inhibitory effects through selective antagonism of PDE4, leading to protein kinase A activation and subsequent Hh blockade .

HY-100246

CI-1044 PD-189659	Phosphodiesterase (PDE)	Inflammation/Immunology
CI-1044 is an orally active *PDE4* inhibitor with IC₅₀s of 0.29, 0.08, 0.56, 0.09 μM for *PDE4A5, PDE4B2, PDE4C2* and *PDE4D3*, respectively.

HY-15178

Oglemilast GRC 3886	Phosphodiesterase (PDE)	Inflammation/Immunology
Oglemilast (GRC 3886) is a potent and orally active **phosphodiesterase-4 (PDE4) inhibitor with an IC₅₀** of 0.5 nM for PDE4D3. Oglemilast inhibits pulmonary cell infiltration, including eosinophilia and neutrophilia in vitro and in vivo. Oglemilast has the potential for inflammatory airway diseases .

HY-103050

ML-030 1 Publications Verification	Phosphodiesterase (PDE)	Inflammation/Immunology
ML-030 is a potent *PDE4* inhibitor, with IC₅₀ of 6.7 nM, 12.9 nM, 48.2 nM, 37.2 nM, 452 nM and 49.2 nM for PDE4A, PDE4A1, PDE4B1, PDE4B2, PDE4C1,and PDE4D2, respectively.

HY-112704

PDE5-IN-2	Phosphodiesterase (PDE)	Cardiovascular Disease
PDE5-IN-2 is a potent, highly selective, and orally active *PDE5* inhibitor, with an IC₅₀ of 0.31 nM, less potently inhibits PDE2A, PDE10A, PDE4D2, and PDE6C, with IC₅₀s of 106, 46, 43, 1.2 nM, respectively. Anti-pulmonary arterial hypertension activity .

HY-122942

Moracin M	Phosphodiesterase (PDE) Endogenous Metabolite NF-κB Autophagy	Inflammation/Immunology
Moracin M is a phenolic component that can be isolated from Mori Cortex, is a potent **phosphodiesterase-4 (PDE4) inhibitor with IC₅₀** values of 2.9, 4.5, >40, and >100 μM for PDE4D2, PDE4B2, PDE5A1, and PDE9A2, respectively. Moracin M has anti-inflammatory activity .

HY-128358

MR-L2	Phosphodiesterase (PDE)	Neurological Disease
MR-L2 is a reversible and noncompetitive allosteric activator of long-isoform **phosphodiesterase-4 (PDE4)*, activates representative PDE4* long-isoform variants (PDE4A4, PDE4B1, PDE4C3, PDE4D5). MR-L2 suppresses PGE2-induced MDCK cell cyst formation with an EC₅₀ of 1.2 µM .

HY-117977

FCPR03	Phosphodiesterase (PDE)	Neurological Disease Inflammation/Immunology
FCPR03 is a potent and selective phosphodiesterase 4 (PDE4) inhibitor with IC₅₀ values of 60 nM, 31 nM and 47 nM for PDE4 catalytic domain, *PDE4B1* and *PDE4D7, respectively. FCPR03 displays at least 2100-fold selectivity over other PDEs* (PDE1-3 and PDE5-11). FCPR03 has anti-inflammatory, neuroprotective and antidepressant-like effects .

Moracin M	Structural Classification Classification of Application Fields Source classification Phenols Polyphenols Plants Moraceae Endogenous metabolite Inflammation/Immunology Disease Research Fields Morus alba Linn.	Phosphodiesterase (PDE) Endogenous Metabolite NF-κB Autophagy
Moracin M is a phenolic component that can be isolated from Mori Cortex, is a potent **phosphodiesterase-4 (PDE4) inhibitor with IC₅₀** values of 2.9, 4.5, >40, and >100 μM for PDE4D2, PDE4B2, PDE5A1, and PDE9A2, respectively. Moracin M has anti-inflammatory activity .

Norbraylin	Toddalia asiatica (L.) Lam. Structural Classification Source classification Rutaceae Coumarins Phenylpropanoids Plants	Phosphodiesterase (PDE)
Norbraylin, a natural prenylated coumarin, is a *PDE4D2* inhibitor with an IC₅₀ value of 7.15 μM .

Species:	Human (2)
Tag:	His (1) Tag Free (1)
Source:	E. coli (2)

Cat. No.	Compare	Product Name	Species	Source

HY-P701961

	PDE4D Protein, Human (His) PDE4D; cAMP-specific 3'; 5'-cyclic phosphodiesterase 4D; DPDE3; PDE43	Human	E. coli
	PDE4D (Phosphodiesterase 4D) protein, as a hydrolytic enzyme, degrades the second messenger cAMP, a crucial regulator in various physiological processes. Its enzymatic activity in breaking down cAMP underscores PDE4D's pivotal role in modulating cellular signaling cascades, maintaining the intricate balance of intracellular communication mediated by this critical second messenger. PDE4D Protein, Human (His) is the recombinant human-derived PDE4D protein, expressed by E. coli , with N-6*His labeled tag. The total length of PDE4D Protein, Human (His) is 328 a.a., .

HY-P701960

	PDE4D Protein, Human PDE4D; cAMP-specific 3'; 5'-cyclic phosphodiesterase 4D; DPDE3; PDE43	Human	E. coli
	PDE4D (Phosphodiesterase 4D) protein, as a hydrolytic enzyme, degrades the second messenger cAMP, a crucial regulator in various physiological processes. Its enzymatic activity in breaking down cAMP underscores PDE4D's pivotal role in modulating cellular signaling cascades, maintaining the intricate balance of intracellular communication mediated by this critical second messenger. PDE4D Protein, Human is the recombinant human-derived PDE4D protein, expressed by E. coli , with tag free. The total length of PDE4D Protein, Human is 328 a.a., .


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