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Results for "

PKC+activator

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Akt (2) Antibiotic (2) Apoptosis (2) Bcl-2 Family (2) Caspase (2) CDK (2) Endogenous Metabolite (1) HBV (2) HIV (2) Influenza Virus (2) Isotope-Labeled Compounds (1) JNK (2) MARCKS (1) NF-κB (1) NOD-like Receptor (NLR) (2) PI3K (2) PKC (27) Reference Standards (3) SphK (1)
By Research Areas:	Cancer (17) Cardiovascular Disease (2) Endocrinology (1) Infection (4) Inflammation/Immunology (8) Neurological Disease (2)

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Natural
Products

Isotope-Labeled Compounds

GMP Molecules

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-18739

Phorbol 12-myristate 13-acetate Maximum Cited Publications 726 Publications Verification PMA; TPA; Phorbol myristate acetate	PKC SphK NF-κB	Neurological Disease Inflammation/Immunology Cancer
Phorbol 12-myristate 13-acetate (PMA; TPA; Phorbol myristate acetate), a phorbol ester, is a dual SphK and protein kinase C (PKC) activator . Phorbol 12-myristate 13-acetate is a NF-κB activator. Phorbol 12-myristate 13-acetate induces differentiation in THP-1 cells (Validated by MedChemExpress (MCE)) .

HY-12359

TPPB 1 Publications Verification	MARCKS PKC	Neurological Disease
TPPB is a cell-permeable benzolactam-derived protein kinase C (PKC) activator with a K_i of 11.9 nM.

HY-18985

Phorbol 12,13-dibutyrate 3 Publications Verification Phorbol dibutyrate; PDBu	PKC	Cancer
Phorbol 12,13-dibutyrate (Phorbol dibutyrate) is a *PKC* activator and a potent skin tumor promoter .

HY-107421

Prostratin 4 Publications Verification	PKC HIV	Infection Cancer
Prostratin, a natural terpenoid compound, is a *PKC* activator, with a K_i of 12.5 nM and shows inhibitory effect on HIV-1.

HY-N0865

Ingenol (-)-Ingenol	PKC	Cancer
Ingenol is a *PKC* activator, with a K_i of 30 μM, with antitumor activity.

HY-13772

Valrubicin 2 Publications Verification AD-32	PKC Antibiotic	Inflammation/Immunology Cancer
Valrubicin is a chemotherapy agent, inhibits TPA- and PDBu-induced *PKC* activation with IC₅₀s of 0.85 and 1.25 μM, respectively, and has antitumor and antiinflammatory activity.

HY-N0699

Daphnoretin 3 Publications Verification Dephnoretin; Thymelol	PKC Influenza Virus NOD-like Receptor (NLR) Apoptosis HBV JNK PI3K Akt CDK Caspase Bcl-2 Family	Infection Inflammation/Immunology Cancer
Daphnoretin (Dephnoretin; Thymelol) is a protein kinase C (PKC) activator that inhibits the expression of hepatitis B virus (HBV) surface antigen (HBsAg) and exhibits antiviral activity. Daphnoretin exerts its antitumor effects by inhibiting the activation of the PI3K/AKT signaling pathway and triggers the mitochondrial apoptosis pathway. Daphnoretin alleviates chondrocyte apoptosis and inflammatory responses by inhibiting endoplasmic reticulum stress and activation of the NLRP3 inflammasome. Daphnoretin regulates the differentiation and maturation of dendritic cells, inhibits their immunostimulatory function by downregulating the phosphorylation level of JNK, and thus exerts a protective effect in skin graft rejection .

HY-12307

(-)-Indolactam V 2 Publications Verification Indolactam V	PKC	Cancer
(-)-Indolactam V is a *PKC* activator, with K_is of 3.36 nM, 1.03 μM for η-CRD2 (PKCη surrogate peptide), γ-CRD2 (PKCγ surrogate peptide), and K_ds of 5.5 nM (η-C1B), 7.7 nM (ε-C1B), 8.3 nM (δ-C1B), 18.9 nM (β-C1A-long), 20.8 nM (α-C1A-long), 137 nM (β-C1B), 138 nM (γ-C1A), 213 nM (γ-C1B), and has antitumor activity.

HY-N4322

Decursinol angelate 1 Publications Verification	PKC	Inflammation/Immunology Cancer
Decursinol angelate acts as a *PKC* activator and GDH inhibitor, with an IC₅₀ of 1.432 μM against human GDH. Decursinol angelate activates PKC, downregulates PKCα and PKCβII isoforms, and exerts cytotoxic activity against cancer cells. Decursinol angelate binds to GDH and inhibits its enzymatic activity. Decursinol angelate inhibits VEGF-induced autophosphorylation of VEGFR2, downstream p42/44 ERK and JNK-MAPK signaling pathways, as well as the angiogenesis process. Decursinol angelate is applicable to research related to cancer and leukemia .

HY-18965

TAS-301	PKC	Cardiovascular Disease
TAS-301 is an inhibitor of smooth muscle cell migration and proliferation, and inhibits *PKC* activation induced by PDGF.

HY-115767

(±)-1,2-Diolein 1,2-Dioleoyl-rac-glycerol	PKC	Others
(±)-1,2-Diolein (1,2-Dioleoyl-rac-glycerol) is a *PKC* activator. (±)-1,2-Diolein increases myotubes Ca ²⁺ influx .

HY-100934

SC-9 NCM 119	PKC	Endocrinology Cancer
SC-9 is a *PKC* activator in the presence of Ca ²⁺ .

HY-141574

1,2-Didecanoyl-Sn-glycerol	PKC	Others
1,2-Didecanoyl-sn-glycerol is an analog of the PKC-activating second messenger DAG. Although the biological activities of 1,2-didecanoyl-sn-glycerol have not been well characterized, it is expected to behave similarly to 1,2-dioctanoyl-sn-glycerol.

HY-P1288

Protein Kinase C (530-558) PKC fragment (530-558)	PKC	Others
Protein Kinase C (530-558), a peptide fragment of protein kinase C (PKC), is a potent *PKC* activator. Protein Kinase C (530-558) significantly inhibits osteoclastic bone resorption .

HY-18985G

Phorbol 12,13-dibutyrate Phorbol dibutyrate; PDBu	PKC	Cancer
Phorbol 12,13-dibutyrate (Phorbol dibutyrate) (GMP) is Phorbol 12,13-dibutyrate (HY-18985) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Phorbol 12,13-dibutyrate is a *PKC* activator and a potent skin tumor promoter .

HY-118834

Teleocidin A1 Lyngbyatoxin A	PKC	Inflammation/Immunology Cancer
Teleocidin A1 (Lyngbyatoxin A) is a *PKC* activator with a K_i value of 0.11 nM for binding to the PKCδ-C1B peptide. Teleocidin A1 exhibits anticancer activity against cervical cancer and leukemia. Teleocidin A1 can induce seaweed dermatitis, food poisoning and local skin toxicity. Teleocidin A1 can be used in studies related to cervical cancer, seaweed dermatitis and food poisoning .

HY-179090

PKC activator-1	PKC	Cancer
PKC activator-1 (compound 26) is a *PKC* activator (K_i = 1.2 nM). PKC activator-1 exhibits cytotoxicity towards various cancer cells. PKC activator-1 is commonly used in cancer research .

HY-129330

Sapintoxin D	PKC	Others
Sapintoxin D is a fluorescent phorbol ester that can be used to study the activation of protein kinase C (PKC). Sapintoxin D is a calcium-dependent PKC activator .

HY-119818

Farnesylthiotriazole FTT	PKC	Cancer
Farnesylthiotriazole (FTT) is a *PKC* activator (K_d=0.8 μM) that can be used in cancer research .

HY-13772R

Valrubicin (Standard) AD-32 (Standard)	Reference Standards PKC Antibiotic	Inflammation/Immunology Cancer
Valrubicin (Standard) is the analytical standard of Valrubicin. This product is intended for research and analytical applications. Valrubicin is a chemotherapy agent, inhibits TPA-and PDBu-induced PKC activation with IC₅₀s of 0.85 and 1.25 μM, respectively, and has antitumor and antiinflammatory activity.

HY-N4322R

Decursinol angelate (Standard)	Reference Standards PKC	Inflammation/Immunology Cancer
Decursinol angelate (Standard) is the analytical standard of Decursinol angelate. This product is intended for research and analytical applications. Decursinol angelate, a cytotoxic and protein kinase C (PKC) activating agent from the root of Angelica gigas, possesses anti-tumor and anti-inflammatory activities .

HY-P1371

Pseudo RACK1 KKWKMRRNQFWIKIQRC CSVEIWD*	PKC	Others
Pseudo RACK1, a peptide, is a PKC agonist with homologous sequences of PKC. Pseudo RACK1 interacts selectively with β-PKC at an autoregulatory site (RACK-binding site) and activates it in the absence of PKC activators, following inducing PKC-mediated histone phosphorylation .

HY-163666

HIV-1 inhibitor-68	HIV PKC	Infection
HIV-1 inhibitor-68 (compound 26) is a protein kinase C (PKC) activator derivative with reversal activity in HIV-1 latency. HIV-1 inhibitor-68 may be able to eliminate cells latently infected with HIV-1, .

HY-W011176

(S)-3-Hydroxypropane-1,2-diyl dioctanoate 1,2-Dioctanoyl-sn-glycerol	Endogenous Metabolite	Others
(S)-3-Hydroxypropane-1,2-diyl dioctanoate (1,2-Dioctanoyl-sn-glycerol) is a cell-permeable analog of the PKC-activating second messenger DAG. (S)-3-Hydroxypropane-1,2-diyl dioctanoate induces acrosome reaction in human sperm.

HY-115767S

(±)-1,2-Diolein-13C3 1,2-Dioleoyl-rac-glycerol-C_C3	Isotope-Labeled Compounds PKC	Others
(±)-1,2-Diolein- ¹³C₃ (1,2-Dioleoyl-rac-glycerol- ¹³C₃) is ¹³C labeled (±)-1,2-Diolein. (±)-1,2-Diolein (1,2-Dioleoyl-rac-glycerol) is a *PKC* activator. (±)-1,2-Diolein increases myotubes Ca ²⁺ influx .

HY-N0699R

Daphnoretin (Standard) Dephnoretin (Standard); Thymelol (Standard)	Reference Standards PKC NOD-like Receptor (NLR) Apoptosis HBV Caspase Akt JNK PI3K CDK Influenza Virus Bcl-2 Family	Infection Inflammation/Immunology Cancer
Daphnoretin (Dephnoretin; Thymelol) (Standard) is the analytical standard of Daphnoretin (HY-N0699). This product is used for research and analytical applications. Daphnoretin is a protein kinase C (PKC) activator that can inhibit the expression of hepatitis B virus (HBV) surface antigen (HBsAg) and has antiviral activity. Daphnoretin exerts its anti-tumor effect by inhibiting the activation of the PI3K/AKT signaling pathway, triggering the mitochondrial apoptosis pathway. Daphnoretin alleviates chondrocyte apoptosis and inflammatory responses by inhibiting endoplasmic reticulum stress and the activation of the NLRP3 inflammasome. Daphnoretin can regulate the differentiation and maturation of dendritic cells, by down-regulating the phosphorylation level of JNK, inhibiting its immune stimulating function, thereby playing a protective role in skin transplant rejection reactions.

HY-18965R

TAS-301 (Standard)	PKC	Cardiovascular Disease
TAS-301 (Standard) is the analytical standard of TAS-301. This product is intended for research and analytical applications. TAS-301 is an inhibitor of smooth muscle cell migration and proliferation, and inhibits PKC activation induced by PDGF.

HY-N9382

Gnidimacrin	PKC	Cancer
Gnidimacrin is a protein kinase C (PKC) activator. Gnidimacrin inhibits cell growth of human leukemias, stomach cancers and non-small cell lung cancers in vitro, and shows activity against murine leukemias and solid tumors in vivo. Gnidimacrin can be used for leukemias, stomach cancers and non-small cell lung cancers research .

Phorbol 12,13-dibutyrate Phorbol dibutyrate; PDBu	Fluorescent Dye
Phorbol 12,13-dibutyrate (Phorbol dibutyrate) (GMP) is Phorbol 12,13-dibutyrate (HY-18985) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Phorbol 12,13-dibutyrate is a *PKC* activator and a potent skin tumor promoter .

Phorbol 12,13-dibutyrate Phorbol dibutyrate; PDBu	Biochemical Assay Reagents
Phorbol 12,13-dibutyrate (Phorbol dibutyrate) (GMP) is Phorbol 12,13-dibutyrate (HY-18985) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Phorbol 12,13-dibutyrate is a *PKC* activator and a potent skin tumor promoter .

Cat. No.	Product Name	Target	Research Area

HY-P1288

Protein Kinase C (530-558) PKC fragment (530-558)	PKC	Others
Protein Kinase C (530-558), a peptide fragment of protein kinase C (PKC), is a potent *PKC* activator. Protein Kinase C (530-558) significantly inhibits osteoclastic bone resorption .

HY-P1371

Pseudo RACK1 KKWKMRRNQFWIKIQRC CSVEIWD*	PKC	Others
Pseudo RACK1, a peptide, is a PKC agonist with homologous sequences of PKC. Pseudo RACK1 interacts selectively with β-PKC at an autoregulatory site (RACK-binding site) and activates it in the absence of PKC activators, following inducing PKC-mediated histone phosphorylation .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-18739

Phorbol 12-myristate 13-acetate Maximum Cited Publications 726 Publications Verification PMA; TPA; Phorbol myristate acetate	Ketones, Aldehydes, Acids Croton tiglium Linn. Euphorbiaceae Plants Inflammation/Immunology Disease Research Fields Source Classification	PKC SphK NF-κB
Phorbol 12-myristate 13-acetate (PMA; TPA; Phorbol myristate acetate), a phorbol ester, is a dual SphK and protein kinase C (PKC) activator . Phorbol 12-myristate 13-acetate is a NF-κB activator. Phorbol 12-myristate 13-acetate induces differentiation in THP-1 cells (Validated by MedChemExpress (MCE)) .

HY-107421

Prostratin 4 Publications Verification	Infection Classification of Application Fields Terpenoids Thymelaeaceae Diterpenoids Plants Disease Research Fields Wikstroemia chamaedaphne Meisn. Source Classification	PKC HIV
Prostratin, a natural terpenoid compound, is a *PKC* activator, with a K_i of 12.5 nM and shows inhibitory effect on HIV-1.

HY-N0865

Ingenol (-)-Ingenol	Classification of Application Fields Terpenoids Gramineae Diterpenoids Leptochloa chinensis (Linn.) Nees Plants Disease Research Fields Source Classification Cancer	PKC
Ingenol is a *PKC* activator, with a K_i of 30 μM, with antitumor activity.

HY-N0699

Daphnoretin 3 Publications Verification Dephnoretin; Thymelol	Infection Structural Classification Monophenols Classification of Application Fields Thymelaeaceae Coumarins Phenols Phenylpropanoids Plants Disease Research Fields Source Classification Wikstroemia indica	PKC Influenza Virus NOD-like Receptor (NLR) Apoptosis HBV JNK PI3K Akt CDK Caspase Bcl-2 Family
Daphnoretin (Dephnoretin; Thymelol) is a protein kinase C (PKC) activator that inhibits the expression of hepatitis B virus (HBV) surface antigen (HBsAg) and exhibits antiviral activity. Daphnoretin exerts its antitumor effects by inhibiting the activation of the PI3K/AKT signaling pathway and triggers the mitochondrial apoptosis pathway. Daphnoretin alleviates chondrocyte apoptosis and inflammatory responses by inhibiting endoplasmic reticulum stress and activation of the NLRP3 inflammasome. Daphnoretin regulates the differentiation and maturation of dendritic cells, inhibits their immunostimulatory function by downregulating the phosphorylation level of JNK, and thus exerts a protective effect in skin graft rejection .

HY-N4322

Decursinol angelate 1 Publications Verification	Structural Classification Pseudognaphalium affine (D. Don) Anderberg Classification of Application Fields Coumarins Phenylpropanoids Umbelliferae Plants Inflammation/Immunology Disease Research Fields Source Classification Cancer	PKC
Decursinol angelate acts as a *PKC* activator and GDH inhibitor, with an IC₅₀ of 1.432 μM against human GDH. Decursinol angelate activates PKC, downregulates PKCα and PKCβII isoforms, and exerts cytotoxic activity against cancer cells. Decursinol angelate binds to GDH and inhibits its enzymatic activity. Decursinol angelate inhibits VEGF-induced autophosphorylation of VEGFR2, downstream p42/44 ERK and JNK-MAPK signaling pathways, as well as the angiogenesis process. Decursinol angelate is applicable to research related to cancer and leukemia .

HY-118834

Teleocidin A1 Lyngbyatoxin A	Alkaloids Structural Classification Microorganisms Classification of Application Fields Disease Research Fields Indole Alkaloids Source Classification Cancer	PKC
Teleocidin A1 (Lyngbyatoxin A) is a *PKC* activator with a K_i value of 0.11 nM for binding to the PKCδ-C1B peptide. Teleocidin A1 exhibits anticancer activity against cervical cancer and leukemia. Teleocidin A1 can induce seaweed dermatitis, food poisoning and local skin toxicity. Teleocidin A1 can be used in studies related to cervical cancer, seaweed dermatitis and food poisoning .

HY-129330

Sapintoxin D	Natural Products Euphorbiaceae Shirakiopsis indica (Willd.) Esser Plants Source Classification	PKC
Sapintoxin D is a fluorescent phorbol ester that can be used to study the activation of protein kinase C (PKC). Sapintoxin D is a calcium-dependent PKC activator .

HY-N4322R

Decursinol angelate (Standard)	Structural Classification Pseudognaphalium affine (D. Don) Anderberg Coumarins Phenylpropanoids Umbelliferae Plants Source Classification	Reference Standards PKC
Decursinol angelate (Standard) is the analytical standard of Decursinol angelate. This product is intended for research and analytical applications. Decursinol angelate, a cytotoxic and protein kinase C (PKC) activating agent from the root of Angelica gigas, possesses anti-tumor and anti-inflammatory activities .

HY-N0699R

Daphnoretin (Standard) Dephnoretin (Standard); Thymelol (Standard)	Structural Classification Monophenols Thymelaeaceae Coumarins Phenols Phenylpropanoids Plants Source Classification Wikstroemia indica	Reference Standards PKC NOD-like Receptor (NLR) Apoptosis HBV Caspase Akt JNK PI3K CDK Influenza Virus Bcl-2 Family
Daphnoretin (Dephnoretin; Thymelol) (Standard) is the analytical standard of Daphnoretin (HY-N0699). This product is used for research and analytical applications. Daphnoretin is a protein kinase C (PKC) activator that can inhibit the expression of hepatitis B virus (HBV) surface antigen (HBsAg) and has antiviral activity. Daphnoretin exerts its anti-tumor effect by inhibiting the activation of the PI3K/AKT signaling pathway, triggering the mitochondrial apoptosis pathway. Daphnoretin alleviates chondrocyte apoptosis and inflammatory responses by inhibiting endoplasmic reticulum stress and the activation of the NLRP3 inflammasome. Daphnoretin can regulate the differentiation and maturation of dendritic cells, by down-regulating the phosphorylation level of JNK, inhibiting its immune stimulating function, thereby playing a protective role in skin transplant rejection reactions.

HY-N9382

Gnidimacrin	Structural Classification Natural Products Thymelaeaceae Stellera chamaejasme Linn. Plants Source Classification	PKC
Gnidimacrin is a protein kinase C (PKC) activator. Gnidimacrin inhibits cell growth of human leukemias, stomach cancers and non-small cell lung cancers in vitro, and shows activity against murine leukemias and solid tumors in vivo. Gnidimacrin can be used for leukemias, stomach cancers and non-small cell lung cancers research .

Cat. No.	Product Name	Chemical Structure

HY-115767S

(±)-1,2-Diolein-13C3
(±)-1,2-Diolein- ¹³C₃ (1,2-Dioleoyl-rac-glycerol- ¹³C₃) is ¹³C labeled (±)-1,2-Diolein. (±)-1,2-Diolein (1,2-Dioleoyl-rac-glycerol) is a *PKC* activator. (±)-1,2-Diolein increases myotubes Ca ²⁺ influx .

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-18985G

Phorbol 12,13-dibutyrate Phorbol dibutyrate; PDBu	PKC	Cancer
Phorbol 12,13-dibutyrate (Phorbol dibutyrate) (GMP) is Phorbol 12,13-dibutyrate (HY-18985) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Phorbol 12,13-dibutyrate is a *PKC* activator and a potent skin tumor promoter .

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PKC+activator

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Peptides

NaturalProducts

Isotope-Labeled Compounds

GMP Molecules

Natural
Products