PKC-IN-1

By Targets:	PKC (12) Akt (1) Apoptosis (3) Aurora Kinase (1) Autophagy (1) CDK (1) DNA-PK (1) Endogenous Metabolite (1) FLT3 (1) HIV (1) NF-κB (1) Reverse Transcriptase (1) SphK (1)
By Research Areas:	Cancer (9) Infection (1) Inflammation/Immunology (3) Metabolic Disease (1)

Targets Recommended: PKC AIM2 NEKs

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-16903

*PKC-IN-1*	PKC	Inflammation/Immunology
PKC-IN-1 is a potent, ATP-competitive and reversible inhibitor of conventional PKC enzymes with K_is of 5.3 and 10.4 nM for human PKCβ and PKCα, and IC₅₀s of 2.3, 8.1, 7.6, 25.6, 57.5, 314, 808 nM for PKCα, PKCβI, PKCβII, PKCθ, PKCγ, PKC mu and PKCε, respectively.

HY-144307

Aurora A/PKC-IN-1	Aurora Kinase PKC	Cancer
Aurora A/PKC-IN-1 (Compound 2e) is a potent dual inhibitor of Aurora A (AurA) and PKC (α, β1, β2, and θ) kinases with IC₅₀s of 6.9 nM and 16.9 nM for AurA and PKCα, respectively. Aurora A/PKC-IN-1 has antiproliferative activity in breast cancer cells and antimetastatic activity ^[1].

HY-108604

Bisindolylmaleimide II

Bis II
PKC Metabolic Disease Cancer

Bisindolylmaleimide II is a general inhibitor of all PKC subtypes .
HY-P3770

Phosphate acceptor peptide

PKC Others

Phosphate acceptor peptide is a substrate for cAMP-dependent protein kinase (PKA). phosphate acceptor peptide is also a weak PKC inhibitor .
HY-P5885

PKCη pseudosubstrate inhibitor,myristoylated

PKC Others

PKCη pseudosubstrate inhibitor,myristoylated is cell permeable and can be used to study the mechanism of action of PKCη .

Bisindolylmaleimide II Bis II	PKC	Metabolic Disease Cancer
Bisindolylmaleimide II is a general inhibitor of all PKC subtypes .

Phosphate acceptor peptide	PKC	Others
Phosphate acceptor peptide is a substrate for cAMP-dependent protein kinase (PKA). phosphate acceptor peptide is also a weak *PKC* inhibitor .

PKCη pseudosubstrate inhibitor,myristoylated	PKC	Others
PKCη pseudosubstrate inhibitor,myristoylated is cell permeable and can be used to study the mechanism of action of *PKCη* .

HY-P5884

PKCθ pseudosubstrate peptide inhibitor,myristoylated	PKC	Others
PKCθ pseudosubstrate peptide inhibitor, myristoylated is a synthetic peptide that can be used to study the mechanism of action of *PKCθ* .

HY-10342

Enzastaurin 5+ Cited Publications LY317615	PKC Autophagy Apoptosis	Cancer
Enzastaurin (LY317615) is a potent and selective PKCβ inhibitor with an IC₅₀ of 6 nM, showing 6- to 20-fold selectivity over PKCα, PKCγ and PKCε .

HY-P3892

Protein Kinase C (19-35) Peptide	PKC	Inflammation/Immunology
Protein Kinase C (19-35) Peptide is the PKC pseudosubstrate inhibitor/region. Protein Kinase C (19-35) Peptide possibly blocks the substrate-binding site in its kinase domain, makes the cytoplasmic form of *PKC* inactive .

HY-18739

Phorbol 12-myristate 13-acetate Maximum Cited Publications 243 Publications Verification PMA; TPA; Phorbol myristate acetate	PKC SphK NF-κB	Inflammation/Immunology
Phorbol 12-myristate 13-acetate (PMA), a phorbol ester, is a dual SphK and protein kinase C (PKC) activator . Phorbol 12-myristate 13-acetate is a NF-κB activator. Phorbol 12-myristate 13-acetate induces differentiation in THP-1 cells .

HY-108263

3-Hydroxy Midostaurin CGP52421	FLT3	Cancer
3-Hydroxy Midostaurin (CGP 52421), a metabolite of PKC412, effectively inhibits FMS-like tyrosine kinase-3 (FLT3) autophosphorylation with IC₅₀s of approximately 132 nM and 9.8 μM in culture medium and plasma, respectively. 3-Hydroxy Midostaurin is less selective but more cytotoxic than PKC412 .

HY-163362

HIV-1 inhibitor-65	Reverse Transcriptase PKC HIV	Infection
HIV-1 inhibitor-65 (compound 3c) is an inhibitor of HIV-1 (EC₅₀: 2.9 nM) and an activator of protein kinase C (PKC). HIV-1 inhibitor-65 inhibits syncytium formation (EC₅₀: 7.0 nM) and inhibits HIV-1 entry and HIV-1 reverse transcriptase ^[1].

HY-126477

NNK	Endogenous Metabolite	Cancer
NNK is a nicotine-nitrosated derivative. NNK simultaneously stimulates Bcl2 phosphorylation exclusively at Ser ⁷⁰ and c-Myc at Thr ⁵⁸ and Ser ⁶² through activation of both *ERK1/2* and *PKCα* . NNK induces survival and proliferation of human lung cancer cells. NNK can be used for lung cancer mice model structure .

HY-142943

DNA-PK-IN-1	DNA-PK	Cancer
DNA-PK-IN-1 is a potent inhibitor of DNA-PK. DNA-dependent protein kinase (DNA-PK) is a DNA-PK enzyme complex composed of Ku70/Ku80 heterodimer and DNA-dependent protein kinase catalytic subunit (DNA-PKcs). DNA-PK-IN-1 has the potential for the research of cancer diseases (extracted from patent WO2021136463A1, compound 1) ^[1].

HY-13335

PKCβ inhibitor 1	PKC Apoptosis	Cancer
PKCβ inhibitor 1 is a potent, ATP-competitive, and selective PKCβ inhibitor with IC₅₀s of 21 and 5 nM for human PKCβ1 and PKCβ2, respectively. PKCβ inhibitor 1 exhibits selectivity of more than 60-fold in favor of PKCβ2 relative to other PKC isozymes (PKCα, PKCγ, and PKCε) .

HY-11009

CGP60474 5 Publications Verification	CDK PKC	Cancer
CGP60474, a highly potent anti-endotoxemic agent, is a potent cyclin-dependent kinase (CDK) inhibitor (IC₅₀ values are 26, 3, 4, 216, 10, 200 and 13 nM for CDK1/B, CDK2/E, CDK2/A, CDK4/D, CDK5/p25, CDK7/H and CDK9/T, respectively). CGP60474 is a selective and ATP-competitive *PKC* inhibitor .

HY-126257

AKT-IN-3	Akt Apoptosis	Cancer
AKT-IN-3 (compound E22) is a potent, orally active low hERG blocking Akt inhibitor, with 1.4 nM, 1.2 nM and 1.7 nM for Akt1, Akt2 and Akt3, respectively. AKT-IN-3 (compound E22) also exhibits good inhibitory activity against other AGC family kinases, such as PKA, PKC, ROCK1, RSK1, P70S6K, and SGK. AKT-IN-3 (compound E22) induces apoptosis and inhibits metastasis of cancer cells ^[1].

Cat. No.	Product Name	Target	Research Area

HY-P3770

Phosphate acceptor peptide

PKC Others

Phosphate acceptor peptide is a substrate for cAMP-dependent protein kinase (PKA). phosphate acceptor peptide is also a weak PKC inhibitor .
HY-P5885

PKCη pseudosubstrate inhibitor,myristoylated

PKC Others

PKCη pseudosubstrate inhibitor,myristoylated is cell permeable and can be used to study the mechanism of action of PKCη .

Phosphate acceptor peptide	PKC	Others
Phosphate acceptor peptide is a substrate for cAMP-dependent protein kinase (PKA). phosphate acceptor peptide is also a weak *PKC* inhibitor .

PKCη pseudosubstrate inhibitor,myristoylated	PKC	Others
PKCη pseudosubstrate inhibitor,myristoylated is cell permeable and can be used to study the mechanism of action of *PKCη* .

HY-P5884

PKCθ pseudosubstrate peptide inhibitor,myristoylated	PKC	Others
PKCθ pseudosubstrate peptide inhibitor, myristoylated is a synthetic peptide that can be used to study the mechanism of action of *PKCθ* .

HY-P3892

Protein Kinase C (19-35) Peptide	PKC	Inflammation/Immunology
Protein Kinase C (19-35) Peptide is the PKC pseudosubstrate inhibitor/region. Protein Kinase C (19-35) Peptide possibly blocks the substrate-binding site in its kinase domain, makes the cytoplasmic form of *PKC* inactive .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-18739

Phorbol 12-myristate 13-acetate 240+ Cited Publications PMA; TPA; Phorbol myristate acetate	Ketones, Aldehydes, Acids Croton tiglium Linn. Source classification Euphorbiaceae Plants Inflammation/Immunology Disease Research Fields	PKC SphK NF-κB
Phorbol 12-myristate 13-acetate (PMA), a phorbol ester, is a dual SphK and protein kinase C (PKC) activator . Phorbol 12-myristate 13-acetate is a NF-κB activator. Phorbol 12-myristate 13-acetate induces differentiation in THP-1 cells .

HY-126477

NNK	Structural Classification Alkaloids Classification of Application Fields Source classification Pyridine Alkaloids Endogenous metabolite Disease Research Fields Cancer	Endogenous Metabolite
NNK is a nicotine-nitrosated derivative. NNK simultaneously stimulates Bcl2 phosphorylation exclusively at Ser ⁷⁰ and c-Myc at Thr ⁵⁸ and Ser ⁶² through activation of both *ERK1/2* and *PKCα* . NNK induces survival and proliferation of human lung cancer cells. NNK can be used for lung cancer mice model structure .

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