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Results for "

PLpro

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (1) Autophagy (1) Deubiquitinase (2) DNA Methyltransferase (1) Endogenous Metabolite (1) SARS-CoV (17) Virus Protease (1)
By Research Areas:	Cancer (1) Infection (17) Inflammation/Immunology (1)

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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-17542

PLpro inhibitor 5+ Cited Publications	SARS-CoV	Infection
PLpro inhibitor is a potent inhibitor of papain-like protease (PLpro) with an IC₅₀ of 2.6 µM . PLpro inhibitor inhibits SARS-CoV-2 PLpro with an IC₅₀ of 5.0 µM and an EC₅₀ of 21.0 µM .

HY-128427

PLpro-IN-1

SARS-CoV Infection

PLpro-IN-1 (Compound 2) is a SARS-CoV PLpro inhibitor (IC₅₀: 8.7 μM). PLpro-IN-1 can be used for antiviral research .
HY-149256

PLpro/RBD-IN-1

SARS-CoV Infection

PLpro/RBD-IN-1 (compound 5) is a dual SARS-CoV-2 PLpro and spike protein RBD inhibitor with IC₅₀s of 7.197 μM and 8.673 μM, respectively .
HY-161365

PLpro-IN-2

SARS-CoV Infection

PLpro-IN-2 (Compound 16) is an inhibitor for SARS-CoV-2 papain-like protease (PLpro), with an IC₅₀ of 0.25 μM .

PLpro-IN-1	SARS-CoV	Infection
PLpro-IN-1 (Compound 2) is a SARS-CoV *PLpro* inhibitor (IC₅₀: 8.7 μM). PLpro-IN-1 can be used for antiviral research .

PLpro/RBD-IN-1	SARS-CoV	Infection
PLpro/RBD-IN-1 (compound 5) is a dual SARS-CoV-2 PLpro and spike protein RBD inhibitor with IC₅₀s of 7.197 μM and 8.673 μM, respectively .

PLpro-IN-2	SARS-CoV	Infection
PLpro-IN-2 (Compound 16) is an inhibitor for SARS-CoV-2 papain-like protease (PLpro), with an IC₅₀ of 0.25 μM .

HY-144648

*Mpro/PLpro-IN-1*	SARS-CoV	Infection
Mpro/PLpro-IN-1 (Compound 29) is a potent inhibitor of M ^pro/PL ^pro. Mpro/PLpro-IN-1 is a dual acting SARS-CoV-2 proteases inhibitor featuring micromolar inhibitory potency versus M ^pro (IC₅₀ = 1.72 μM) and submicromolar potency versus PL ^pro (IC₅₀ = 0.67 μM) .

HY-157144

SARS-CoV-2-IN-68	SARS-CoV	Infection
SARS-CoV-2-IN-68 (compound 6C) is a covalent SARS-CoV-2 PLpro/Mpro inhibitor with potent antiviral activities. SARS-CoV-2-IN-68 binds to Zn-finger domain of PLpro .

HY-155308

SARS-CoV-2-IN-61

SARS-CoV Infection

SARS-CoV-2-IN-61 (compound 8i) is a SARS CoV-2 PLpro inhibitor with an IC₅₀ of 16 µM. SARS-CoV-2-IN-61 has antiviral activities .

SARS-CoV-2-IN-61	SARS-CoV	Infection
SARS-CoV-2-IN-61 (compound 8i) is a SARS CoV-2 PLpro inhibitor with an IC₅₀ of 16 µM. SARS-CoV-2-IN-61 has antiviral activities .

HY-W423489

SARS-CoV-2-IN-76 S-Adenosyl-DL-homocysteine	SARS-CoV	Infection
SARS-CoV-2-IN-76 (compound 1) is a nsp14-viral cap N7 methyltranferase and *PLpro* inhibitor of severe acute respiratory syndrome corona virus (SARS-CoV-2) .

HY-13765

6-Thioguanine 5+ Cited Publications Thioguanine; 2-Amino-6-purinethiol	SARS-CoV Deubiquitinase DNA Methyltransferase Autophagy Apoptosis Endogenous Metabolite	Infection Inflammation/Immunology Cancer
6-Thioguanine (Thioguanine; 2-Amino-6-purinethiol) is an anti-leukemia and immunosuppressant agent, acts as an inhibitor of SARS and MERS coronavirus papain-like proteases (PLpros) and also potently inhibits USP2 activity, with IC₅₀s of 25 μM and 40 μM for Plpros and recombinant human USP2, respectively.

HY-P4388

Z-Arg-Leu-Arg-Gly-Gly-AMC

SARS-CoV Infection

Z-Arg-Leu-Arg-Gly-Gly-AMC is a peptide substrate of SARS-CoV PL ^pro .
HY-139892

XR8-69

SARS-CoV Infection

XR8-69 is a SARS-CoV-2 PLpro inhibitor that shows low micromolar antiviral potency in SARS-CoV-2-infected human cells.
HY-150789

SARS-CoV-2-IN-23

SARS-CoV Infection

SARS-CoV-2-IN-23 (compound GRL-0617) is a SARS-COV-2 papain-like protease (PLpro) inhibitor with an IC₅₀ value of 2.3 μM .

Z-Arg-Leu-Arg-Gly-Gly-AMC	SARS-CoV	Infection
Z-Arg-Leu-Arg-Gly-Gly-AMC is a peptide substrate of SARS-CoV PL ^pro .

XR8-69	SARS-CoV	Infection
XR8-69 is a SARS-CoV-2 PLpro inhibitor that shows low micromolar antiviral potency in SARS-CoV-2-infected human cells.

SARS-CoV-2-IN-23	SARS-CoV	Infection
SARS-CoV-2-IN-23 (compound GRL-0617) is a SARS-COV-2 papain-like protease (PLpro) inhibitor with an IC₅₀ value of 2.3 μM .

HY-N1910

4'-O-Methylbavachalcone 1 Publications Verification
4'-O-Methylbavachalcone is a chalcone isolated from Psoralea corylifolia, inhibits severe acute respiratory syndrome coronavirus (SARS-CoV) papain-like protease (PLpro) activity, with an IC₅₀ of 10.1 μM .

HY-152589

Antiviral agent 25	SARS-CoV	Infection
Antiviral agent 25 (compound 6g) is a new non-peptide analog covalent inhibitor of SARS-CoV-2 3CL ^pro. Antiviral agent 25 has a strong inhibitory effect on SARS-CoV-2 3CL ^pro and SARS-CoV-2 PL ^pro with IC₅₀ values of 0.118 µM, 0.448 µM, respectively. Antiviral agent 25 has antiviral effect on SARS-CoV-2 with an EC₅₀ value of 7.249 µM .

HY-149940

SIMR3030	SARS-CoV	Infection
SIMR3030 is a potent SARS-CoV-2 PLpro inhibitor with an IC₅₀ value of 0.0399 µg/mL. SIMR3030 shows antiviral activity. SIMR3030 decreases SARS-CoV spike, ORF1b, IFN-α, IL-6 mRNA expression. SIMR3030 exhibits a satisfactory safety profile in mice .

HY-117043

GRL0617 Maximum Cited Publications 7 Publications Verification	Deubiquitinase SARS-CoV	Infection
GRL0617 is a selective and competitive noncovalent inhibitor of severe acute respiratory syndrome (SARS-CoV) papain-like protease (PLpro), with an IC₅₀ of 0.6 μM and a Ki value of 0.49 μM. GRL0617 also inhibits SARS-CoV with an EC₅₀ of 14.5 μM. GRL0617 can be used for the research of severe acute respiratory syndrome .

HY-152101

LY1	SARS-CoV	Infection
LY1 is a potent, selective and covalent inhibitor against both SARS-CoV-2 PL ^pro and M ^pro with K_d values of 1.5 μM and 2.3 μM for M ^pro C145A protein and PL ^pro C111A protein, respectively. LY1 potent against the viral proteases, with IC₅₀s of 0.12 μM and 0.99 μM against M ^pro and PL ^pro. LY1 shows high selectivity over other kinases, human proteases and metalloenzyme .

HY-144647

SP inhibitor 1	SARS-CoV Virus Protease	Infection
SP inhibitor 1 (compound 34) is a selective SARS-CoV-2 spike protein (SP) inhibitor with an IC₅₀ of 3.26 μM, >25 μM, >25 μM for SP, M ^pro and PL ^pro protein, respectively. SP inhibitor 1 is a vitro SARS-CoV-2 replication inhibitor at non-toxic concentrations (0.3250<5.98 μM). SP inhibitor 1 shows cellular antiviral activity .

Cat. No.	Product Name

HY-L052

Anti-COVID-19 Compound Library	1477 compounds
COVID-19 poses a serious threat to people's health, and it is urgent to develop drugs to treat COVID-19 quickly. The screening of anti-COVID-19 drugs by using the clinical and approved compounds can greatly shorten the research and development cycle. In addition, the virtual screening technology can effectively narrow the scope of screening and improve the screening efficiency in the pre-screening of new drugs. Taking advantage of our virtual screening, we conduct virtual screening of approved compound library and clinical compound library based on the 3CL protease (PDB ID: 6LU7), Spike Glycoprotein (PDB ID: 6VSB), NSP15 (PDB ID: 6VWW), RDRP, PLPro and ACE2 (Angiotensin Converting Enzyme 2) structure. We design a unique collection of 1477 compounds which may have anti-COVID-19 activity. Anti-COVID-19 Compound Library will be a powerful tool for screening new anti-COVID-19 activity drugs.

Anti-COVID-19 Compound Library

1477 compounds

COVID-19 poses a serious threat to people's health, and it is urgent to develop drugs to treat COVID-19 quickly. The screening of anti-COVID-19 drugs by using the clinical and approved compounds can greatly shorten the research and development cycle. In addition, the virtual screening technology can effectively narrow the scope of screening and improve the screening efficiency in the pre-screening of new drugs.

Taking advantage of our virtual screening, we conduct virtual screening of approved compound library and clinical compound library based on the 3CL protease (PDB ID: 6LU7), Spike Glycoprotein (PDB ID: 6VSB), NSP15 (PDB ID: 6VWW), RDRP, PLPro and ACE2 (Angiotensin Converting Enzyme 2) structure. We design a unique collection of 1477 compounds which may have anti-COVID-19 activity. Anti-COVID-19 Compound Library will be a powerful tool for screening new anti-COVID-19 activity drugs.

Cat. No.	Product Name	Target	Research Area

HY-P4388

Z-Arg-Leu-Arg-Gly-Gly-AMC

SARS-CoV Infection

Z-Arg-Leu-Arg-Gly-Gly-AMC is a peptide substrate of SARS-CoV PL ^pro .

Z-Arg-Leu-Arg-Gly-Gly-AMC	SARS-CoV	Infection
Z-Arg-Leu-Arg-Gly-Gly-AMC is a peptide substrate of SARS-CoV PL ^pro .

6-Thioguanine 5+ Cited Publications Thioguanine; 2-Amino-6-purinethiol	Infection Structural Classification Natural Products Classification of Application Fields Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields Cancer	SARS-CoV Deubiquitinase DNA Methyltransferase Autophagy Apoptosis Endogenous Metabolite
6-Thioguanine (Thioguanine; 2-Amino-6-purinethiol) is an anti-leukemia and immunosuppressant agent, acts as an inhibitor of SARS and MERS coronavirus papain-like proteases (PLpros) and also potently inhibits USP2 activity, with IC₅₀s of 25 μM and 40 μM for Plpros and recombinant human USP2, respectively.

Species:	Virus (5)
Tag:	His (4) Tag Free (1) Avi (1)
Source:	E. coli (5)

Cat. No.	Compare	Product Name	Species	Source

HY-P70122

	*SARS-CoV-2 PLpro* Protein** 1 Publications Verification rReplicase polyprotein 1ab/2019-nCoV Papain-Like Protease; Papain-like Protease; PLpro; PL-PRO; pp1a; Replicase polyprotein 1a	Virus	E. coli
	The multifunctional SARS-CoV-2 PP1ab protein is essential for viral RNA transcription and replication, utilizing proteases for multi-protein cleavage. It inhibits host translation by binding to the 40S subunit and blocks ribosomal mRNA entry channels, thereby hindering the antiviral response. SARS-CoV-2 PLpro Protein is the recombinant Virus-derived SARS-CoV-2 PLpro protein, expressed by E. coli , with tag free. The total length of SARS-CoV-2 PLpro Protein is 315 a.a., with molecular weight of ~34.0 kDa.

HY-P74581

	*SARS-CoV Plpro/papain-like protease Protein (His)* SARS-CoV (strain WH20) PLpro / papain-like protease	Virus	E. coli
	SARS CoV ORF1ab polyprotein (PP1ab) is a 7073 residues long polyprotein which further produces 5 non-structural proteins (NSPs) after processing through virally encoded proteases (NSP12-NSP16). All these 5 proteins are mainly involved in viral replication, assembly, and immune response modulation. SARS-CoV Plpro/papain-like protease Protein (His) is the recombinant Virus-derived SARS-CoV Plpro/papain-like protease protein, expressed by E. coli , with C-His labeled tag. The total length of SARS-CoV Plpro/papain-like protease Protein (His) is 319 a.a., with molecular weight of ~36.91 kDa.

HY-P77831

	*SARS Plpro/papain-like protease Protein (His-Avi)* Replicase polyprotein 1a; pp1a; nsp1; PL2-PRO; PL-PRO; Papain-like Protease; PLpro	Virus	E. coli
	The multifunctional SARS Plpro/papain-like protease protein utilizes essential proteases for multi-protein cleavage to strategically coordinate viral RNA transcription and replication. It blocks host translation by interacting with the 40S ribosomal subunit, causing endonucleolytic cleavage near the 5'UTR of host mRNAs, thereby targeting them for degradation. SARS Plpro/papain-like protease Protein (His-Avi) is the recombinant Virus-derived SARS Plpro/papain-like protease protein, expressed by E. coli , with N-His, N-Avi labeled tag. The total length of SARS Plpro/papain-like protease Protein (His-Avi) is 314 a.a., with molecular weight of ~38.6 kDa.

HY-P702190

	PL-PRO Protein, 2019-nCoV (His) Replicase polyprotein 1a; pp1a; ORF1a polyprotein	Virus	E. coli
	The multifunctional PL-PRO protein plays a critical role in viral RNA transcription and replication, providing the necessary proteases for multiprotein cleavage. It strategically blocks host translation by binding to the open head conformation of the 40S subunit, impeding ribosomal mRNA entry into the tunnel. PL-PRO Protein, 2019-nCoV (His) is the recombinant Virus-derived PL-PRO protein, expressed by E. coli , with N-6*His labeled tag. The total length of PL-PRO Protein, 2019-nCoV (His) is 312 a.a., .

HY-P76021

	*SARS-CoV-2 Plpro/Papain-like protease Protein (His)* SARS-CoV-2 (2019-nCoV) PLpro/papain-like protease-His Protein	Virus	E. coli
	SARS-CoV-2 NSP3 (NSP3) is one of non-structure protein that binds to viral RNA, nucleocapsid protein, as well as other viral proteins, and contributes in polyprotein processing. NSP3 has also an important role in innate immune response antagonism and is responsible for release of NSP1, NSP2, and NSP3 from the N-terminal region of pp1a and pp1ab. SARS-CoV-2 Plpro/Papain-like protease Protein (His) is the recombinant Virus-derived SARS-CoV-2 Plpro/Papain-like protease protein, expressed by E. coli , with N-His labeled tag. The total length of SARS-CoV-2 Plpro/Papain-like protease Protein (His) is 317 a.a., with molecular weight of ~36.79 kDa.


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