PMA

By Targets:	Bacterial (2) CCR (1) Fluorescent Dye (1) Influenza Virus (1) MMP (3) nAChR (1) NF-κB (3) p38 MAPK (1) Phospholipase (1) PKC (2) Reactive Oxygen Species (1) SphK (1)
By Research Areas:	Cancer (4) Endocrinology (1) Infection (4) Inflammation/Immunology (7) Neurological Disease (1)
Click Chemistry:	Azide (1)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-18739

Phorbol 12-myristate 13-acetate Maximum Cited Publications 243 Publications Verification PMA; TPA; Phorbol myristate acetate	PKC SphK NF-κB	Inflammation/Immunology
Phorbol 12-myristate 13-acetate (PMA), a phorbol ester, is a dual SphK and protein kinase C (PKC) activator . Phorbol 12-myristate 13-acetate is a NF-κB activator. Phorbol 12-myristate 13-acetate induces differentiation in THP-1 cells .

HY-N2497

Isoliquiritin apioside 1 Publications Verification	NF-κB MMP p38 MAPK	Cancer
Isoliquiritin apioside significantly decreases PMA-induced increases in MMP9 activities and suppresses PMA-induced activation of MAPK and NF-κB. Isoliquiritin apioside auppresseses invasiveness and angiogenesis of cancer cells and endothelial cells .

HY-P5718

Brevinin-1PMa	Bacterial	Infection
Brevinin-1PMa is a host-defense peptide that exhibits antimicrobial activity against Staphylococcus aureus and Echerichia coli. Brevinin-1PMa also shows hemolytic activity .

HY-P5713

Des(8-14)brevinin-1PMa	Bacterial	Infection
Des(8-14)brevinin-1PMa is a host-defense peptide that exhibits antimicrobial activity against Staphylococcus aureus and Echerichia coli. Des(8-14)brevinin-1PMa also shows hemolytic activity .

HY-N11934

Piperkadsin A	Reactive Oxygen Species	Inflammation/Immunology Cancer
Piperkadsin A is a potent inhibitor of ROS. Piperkadsin inhibits PMA-induced ROS production in human polymorphonuclear neutrophils with an IC₅₀ of 4.3 μM .

HY-N6862

Lucideric acid A	MMP	Cancer
Lucideric acid A is a natural compound isolated from Ganoderma lucidum, inhibits PMA-induced MMP-9 activity, with anti-invasive effect on hepatoma cells .

HY-N6860

Lucidenic acid C	MMP	Cancer
Lucidenic acid C is a natural compound isolated from Ganoderma lucidum, inhibits PMA-induced MMP-9 activity, with anti-invasive effect on hepatoma cells .

HY-D1444

Propidium monoazide	Fluorescent Dye	Infection
Propidium monoazide is a photoreactive DNA-binding dye that preferentially binds to dsDNA. Propidium monoazide (PMA) prevents DNA from dead bacteria from being amplified during the PCR. PMA-PCR enhanced both the specificity and the sensitivity of PCR . Propidium monoazide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

HY-N5051

25(S)-Ruscogenin-1-O-α-L-rhamnopyranosyl (1→2)-β-D-xylopyranoside	Others	Inflammation/Immunology
25(S)-Ruscogenin-1-O-α-L-rhamnopyranosyl (1→2)-β-D-xylopyranoside shows inhibitory activity of neutrophil respiratory burst stimulated by PMA(phorbol myristate acetate) .

HY-N0699

Daphnoretin 1 Publications Verification Dephnoretin; Thymelol	PKC Influenza Virus	Infection
Daphnoretin (Dephnoretin), isolated from Wikstroemia indica, possesses antiviral activity . Daphnoretin likes PMA, may direct activation of protein kinase C which in turn activated NADPH oxidase and elicited respiratory burst .

HY-118725

Luffariellolide	Phospholipase	Inflammation/Immunology
Luffariellolide is an inhibitor of human synovial fluid phospholipase A2 (HSF-PLA2) (IC₅₀=5 μM). Luffariellolide effectively inhibits phorbol ester (PMA)-induced ear edema (ED₅₀=50 μg/ear) .

HY-12152

PNU-120596 NSC 216666	nAChR	Neurological Disease Inflammation/Immunology
PNU-120596 (NSC 216666) is a potent and selective α7 nAChR positive allosteric modulator (PMA) with an EC₅₀ of 216 nM. PNU-120596 is inactive against α4β2, α3β4, and α9α10 nAChRs. PNU-120596 has the potential for psychiatric and neurological disorders research .

HY-N2609

7,4'-Dihydroxyflavone 1 Publications Verification	CCR NF-κB	Inflammation/Immunology Endocrinology
7,4'-Dihydroxyflavone (7,4'-DHF) is a flavonoid, which can be isolated from Glycyrrhiza uralensis. 7,4'-Dihydroxyflavone is eotaxin/CCL11 inhibitor and CBR1 inhibitor (IC₅₀=0.28 μM). 7,4'-Dihydroxyflavone has the ability to consistently suppress eotaxin production and prevent dexamethasone (Dex)‐paradoxical adverse effects on eotaxin production . 7,4'-Dihydroxyflavone (7,4'-DHF) inhibits MUC5AC gene expression, mucus production and secretion via regulation of NF-κB, STAT6 and HDAC2.7,4'-Dihydroxyflavone (7,4'-DHF) decreases phorbol 12-myristate 13-acetate (PMA) stimulated NCI-H292 human airway epithelial cell MUC5AC gene expression and mucus production with IC₅₀ value of 1.4 µM .

Cat. No.	Product Name	Type

HY-D1444

Propidium monoazide	DNA Stain
Propidium monoazide is a photoreactive DNA-binding dye that preferentially binds to dsDNA. Propidium monoazide (PMA) prevents DNA from dead bacteria from being amplified during the PCR. PMA-PCR enhanced both the specificity and the sensitivity of PCR . Propidium monoazide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

Propidium monoazide

DNA Stain

Propidium monoazide is a photoreactive DNA-binding dye that preferentially binds to dsDNA. Propidium monoazide (PMA) prevents DNA from dead bacteria from being amplified during the PCR. PMA-PCR enhanced both the specificity and the sensitivity of PCR . Propidium monoazide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

Cat. No.	Product Name	Target	Research Area

HY-P5718

Brevinin-1PMa	Bacterial	Infection
Brevinin-1PMa is a host-defense peptide that exhibits antimicrobial activity against Staphylococcus aureus and Echerichia coli. Brevinin-1PMa also shows hemolytic activity .

HY-P5713

Des(8-14)brevinin-1PMa	Bacterial	Infection
Des(8-14)brevinin-1PMa is a host-defense peptide that exhibits antimicrobial activity against Staphylococcus aureus and Echerichia coli. Des(8-14)brevinin-1PMa also shows hemolytic activity .

HY-P10048

TAT-JIP

Peptides Inflammation/Immunology

TAT-JIP inhibits the phosphorylation of endogenous c-jun activated by PHA–PMA .

TAT-JIP	Peptides	Inflammation/Immunology
TAT-JIP inhibits the phosphorylation of endogenous c-jun activated by PHA–PMA .

HY-P5452

PKCd (8-17)	Peptides	Others
PKCd (8-17) is a biological active peptide. (This peptide is derived from the V1 domain of protein kinase C (PKC)d. It inhibits phorbol 12-myristate 13-acetate (PMA)-induced PKCd translocation and activation. Inhibition of PKCd reduces ischemia damage in cardiac and cerebral cells, induces proliferation of fibroblasts, and inhibits graft coronary artery disease in mice.)

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-18739

Phorbol 12-myristate 13-acetate Maximum Cited Publications 243 Publications Verification PMA; TPA; Phorbol myristate acetate	Ketones, Aldehydes, Acids Croton tiglium Linn. Source classification Euphorbiaceae Plants Inflammation/Immunology Disease Research Fields	PKC SphK NF-κB
Phorbol 12-myristate 13-acetate (PMA), a phorbol ester, is a dual SphK and protein kinase C (PKC) activator . Phorbol 12-myristate 13-acetate is a NF-κB activator. Phorbol 12-myristate 13-acetate induces differentiation in THP-1 cells .

HY-N2497

Isoliquiritin apioside 1 Publications Verification	Flavonoids Chalcones other families Classification of Application Fields Source classification Phenols Polyphenols Plants Disease Research Fields Cancer	NF-κB MMP p38 MAPK
Isoliquiritin apioside significantly decreases PMA-induced increases in MMP9 activities and suppresses PMA-induced activation of MAPK and NF-κB. Isoliquiritin apioside auppresseses invasiveness and angiogenesis of cancer cells and endothelial cells .

HY-N6862

Lucideric acid A	Triterpenes Classification of Application Fields Terpenoids Source classification Polyporaceae Plants Disease Research Fields Cancer	MMP
Lucideric acid A is a natural compound isolated from Ganoderma lucidum, inhibits PMA-induced MMP-9 activity, with anti-invasive effect on hepatoma cells .

HY-N11934

Piperkadsin A	Structural Classification Monophenols Source classification Phenols Piperaceae Plants Piper kadsura (Choisy) Ohwi	Reactive Oxygen Species
Piperkadsin A is a potent inhibitor of ROS. Piperkadsin inhibits PMA-induced ROS production in human polymorphonuclear neutrophils with an IC₅₀ of 4.3 μM .

HY-N6860

Lucidenic acid C	Triterpenes Microorganisms Classification of Application Fields Terpenoids Source classification Polyporaceae Plants Disease Research Fields Cancer	MMP
Lucidenic acid C is a natural compound isolated from Ganoderma lucidum, inhibits PMA-induced MMP-9 activity, with anti-invasive effect on hepatoma cells .

HY-N5051

25(S)-Ruscogenin-1-O-α-L-rhamnopyranosyl (1→2)-β-D-xylopyranoside	Liliaceae Classification of Application Fields Source classification Liriope spicata (Thunb.) Lour. Plants Disease Research Fields Inflammation/Immunology Steroids	Others
25(S)-Ruscogenin-1-O-α-L-rhamnopyranosyl (1→2)-β-D-xylopyranoside shows inhibitory activity of neutrophil respiratory burst stimulated by PMA(phorbol myristate acetate) .

HY-N0699

Daphnoretin 1 Publications Verification Dephnoretin; Thymelol	Infection Monophenols Classification of Application Fields Thymelaeaceae Source classification Coumarins Phenols Phenylpropanoids Plants Disease Research Fields Wikstroemia indica	PKC Influenza Virus
Daphnoretin (Dephnoretin), isolated from Wikstroemia indica, possesses antiviral activity . Daphnoretin likes PMA, may direct activation of protein kinase C which in turn activated NADPH oxidase and elicited respiratory burst .

HY-118725

Luffariellolide	Natural Products Classification of Application Fields Animals Source classification Disease Research Fields Inflammation/Immunology	Phospholipase
Luffariellolide is an inhibitor of human synovial fluid phospholipase A2 (HSF-PLA2) (IC₅₀=5 μM). Luffariellolide effectively inhibits phorbol ester (PMA)-induced ear edema (ED₅₀=50 μg/ear) .

HY-N2609

7,4'-Dihydroxyflavone 1 Publications Verification	Structural Classification Flavonoids Classification of Application Fields Flavones Leguminosae Source classification Phenols Polyphenols Plants Disease Research Fields Glycyrrhiza uralensis Fisch. Endocrinology	CCR NF-κB
7,4'-Dihydroxyflavone (7,4'-DHF) is a flavonoid, which can be isolated from Glycyrrhiza uralensis. 7,4'-Dihydroxyflavone is eotaxin/CCL11 inhibitor and CBR1 inhibitor (IC₅₀=0.28 μM). 7,4'-Dihydroxyflavone has the ability to consistently suppress eotaxin production and prevent dexamethasone (Dex)‐paradoxical adverse effects on eotaxin production . 7,4'-Dihydroxyflavone (7,4'-DHF) inhibits MUC5AC gene expression, mucus production and secretion via regulation of NF-κB, STAT6 and HDAC2.7,4'-Dihydroxyflavone (7,4'-DHF) decreases phorbol 12-myristate 13-acetate (PMA) stimulated NCI-H292 human airway epithelial cell MUC5AC gene expression and mucus production with IC₅₀ value of 1.4 µM .

Cat. No.	Product Name		Classification

HY-D1444

Propidium monoazide		Azide
Propidium monoazide is a photoreactive DNA-binding dye that preferentially binds to dsDNA. Propidium monoazide (PMA) prevents DNA from dead bacteria from being amplified during the PCR. PMA-PCR enhanced both the specificity and the sensitivity of PCR . Propidium monoazide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

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Fluorescent Dye

Peptides

NaturalProducts

Click Chemistry

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