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Isoforms Recommended:	PRMT6

Results for "

PRMT6

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (3) Histone Methyltransferase (24) Parasite (2) Phosphodiesterase (PDE) (2) Small Interfering RNA (siRNA) (3)
By Research Areas:	Cancer (24) Infection (2) Inflammation/Immunology (3)

Inhibitors & Agonists

Peptides

Recombinant Proteins

Antibodies

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-RS11177

PRMT6 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
PRMT6 Human Pre-designed siRNA Set A contains three designed siRNAs for PRMT6 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

PRMT6 Human Pre-designed siRNA Set A PRMT6 Human Pre-designed siRNA Set A

HY-RS11178

Prmt6 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Prmt6 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Prmt6 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Prmt6 Mouse Pre-designed siRNA Set A Prmt6 Mouse Pre-designed siRNA Set A

HY-RS11179

PRMT6 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
PRMT6 Rat Pre-designed siRNA Set A contains three designed siRNAs for PRMT6 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

PRMT6 Rat Pre-designed siRNA Set A PRMT6 Rat Pre-designed siRNA Set A

HY-152236

PRMT6-IN-3	Histone Methyltransferase Apoptosis	Cancer
PRMT6-IN-3 (compound 25) is a selective *PRMT6* inhibitor with an IC₅₀ value of 192 nM. PRMT6-IN-3 can induce apoptosis in cancer cells and has anticancer activity .

HY-126300

SGC6870

Histone Methyltransferase Cancer

SGC6870 is a potent, selective and cytoactive allosteric inhibitor of PRMT6 with IC₅₀ of 77 nM .
HY-126300A

SGC6870N

Histone Methyltransferase Cancer

SGC6870N is inactive against PRMT6 and can be utilized as a negative control. SGC6870N is an inactive enantiomer of SGC6870 (HY-126300) .
HY-P1182

C21

Histone Methyltransferase Cancer

C21 is a potent, irreversible, and selective PRMT1 inhibitor with an IC₅₀ of 1.8 μM. C21 inhibits PRMT6 with an IC₅₀ of 8.8 μM .

SGC6870	Histone Methyltransferase	Cancer
SGC6870 is a potent, selective and cytoactive allosteric inhibitor of *PRMT6* with IC₅₀ of 77 nM .

SGC6870N	Histone Methyltransferase	Cancer
SGC6870N is inactive against PRMT6 and can be utilized as a negative control. SGC6870N is an inactive enantiomer of SGC6870 (HY-126300) .

C21	Histone Methyltransferase	Cancer
C21 is a potent, irreversible, and selective *PRMT1* inhibitor with an IC₅₀ of 1.8 μM. C21 inhibits PRMT6 with an IC₅₀ of 8.8 μM .

HY-12970A

EPZ020411 hydrochloride 5 Publications Verification	Histone Methyltransferase Apoptosis	Cancer
EPZ020411 hydrochloride is a selective inhibitor of *PRMT6* with an IC₅₀ of 10 nM, it has >10 folds selectivity for PRMT6 over PRMT1 and PRMT8. EPZ020411 hydrochloride can be used for the research of cancer .

HY-12970

EPZ020411 5 Publications Verification	Histone Methyltransferase Apoptosis	Cancer
EPZ020411 is a selective inhibitor of *PRMT6* with an IC₅₀ of 10 nM, has >10 folds selectivity for PRMT6 over PRMT1 and PRMT8. EPZ020411 can be used for the research of cancer .

HY-133740

MS117	Histone Methyltransferase	Cancer
MS117 is a first-in-class and cell-active irreversible protein arginine methyltransferase 6 (PRMT6) covalent inhibitor, with an IC₅₀ of 18 nM .

HY-100565

SGC2085 1 Publications Verification	Histone Methyltransferase	Cancer
SGC2085 is a potent and selective inhibitor of coactivator associated arginine methyltransferase 1 (CARM1) with an IC₅₀ of 50 nM. SGC2085 also selectively inhibits *PRMT6* with an IC₅₀ value of 5.2 μM, but not other PRMT proteins .

HY-100565A

SGC2085 hydrochloride	Histone Methyltransferase
SGC2085 hydrochloride is a potent and selective inhibitor of coactivator associated arginine methyltransferase 1 (CARM1) with an IC₅₀ of 50 nM. SGC2085 hydrochloride also selectively inhibits *PRMT6* with an IC₅₀ value of 5.2 μM, but not other PRMT proteins .

HY-162003

DCPT1061	Histone Methyltransferase	Cancer
DCPT1061 potently inhibits PRMT1, PRMT6 and PRMT8 in vitro with less inhibitory effect on PRMT3, PRMT4, and PRMT5 or other epigenetic enzymes. DCPT1061 has antitumor effect .

HY-122096

DCLX069 1 Publications Verification	Histone Methyltransferase	Cancer
DCLX069 is a selective protein arginine methyltransferase 1 (PRMT1) inhibitor with an IC₅₀ value of 17.9 µM. DCLX069 shows less active against PRMT4 and PRMT6. DCLX069 has anticancer effects .

HY-162003A

DCPT1061 hydrochloride	Histone Methyltransferase	Cancer
DCPT1061 hydrochloride has a strong inhibitory effect on *PRMT1, PRMT6, and PRMT8* in vitro, The epigenetic enzymes such as *PRMT3, PRMT4* and *PRMT5* had little inhibitory effect. DCPT1061 hydrochloride has antitumor effects .

HY-155154

PRMT4-IN-2	Others	Cancer
PRMT4-IN-2 (compound 55) is a pan-inhibitor of protein arginine methyltransferase (PRMT) with IC₅₀s of 92 nM (PRMT4), 436 nM (PRMT6), 460 nM (PRMT1), 823 nM ( PRMT8), 1.386 μM (PRMT3) .

HY-19615

MS023 5+ Cited Publications	Histone Methyltransferase	Cancer
MS023 is a potent, selective, and cell-active inhibitor of human type I protein arginine methyltransferases (PRMTs) inhibitor, with IC₅₀s of 30, 119, 83, 4 and 5 nM for *PRMT1, PRMT3, PRMT4, PRMT6, and PRMT8*, respectively .

HY-19615B

MS023 dihydrochloride 5+ Cited Publications	Histone Methyltransferase	Cancer
MS023 dihydrochloride is a potent, selective, and cell-active inhibitor of human type I protein arginine methyltransferases (PRMTs) inhibitor, with IC₅₀s of 30, 119, 83, 4 and 5 nM for *PRMT1, PRMT3, PRMT4, PRMT6, and PRMT8*, respectively .

HY-19615A

MS023 trihydrochloride	Histone Methyltransferase	Cancer
MS023 trihydrochloride is a potent, selective, and cell-active inhibitor of human type I protein arginine methyltransferases (PRMTs) inhibitor, with IC₅₀s of 30, 119, 83, 4 and 5 nM for *PRMT1, PRMT3, PRMT4, PRMT6, and PRMT8*, respectively .

HY-100360

MS049	Histone Methyltransferase	Cancer
MS049 is a potent, selective, and cell-active dual inhibitor of *PRMT4* and *PRMT6* with IC₅₀s of 34 nM and 43 nM, respectively. MS049 reduces levels of Med12me2a and H3R2me2a in HEK293 cells. MS049 is not toxic and does not affect the growth of HEK293 cells .

HY-100855

DC_C66	Histone Methyltransferase	Cancer
DC_C66 is a cell-permeable, selective coactivator associated arginine methyltransferase 1 (CARM1) inhibitor with an IC₅₀ of 1.8 μM. DC_C66 has a good selectivity for CARM1 against PRMT1 (IC₅₀=21 μM), PRMT6 (IC₅₀= 47μM), and PRMT5 .

HY-100360A

MS049 dihydrochloride	Histone Methyltransferase	Cancer
MS049 dihydrochloride is a potent, selective, and cell-active dual inhibitor of *PRMT4* and *PRMT6* with IC₅₀s of 34 nM and 43 nM, respectively. MS049 dihydrochloride reduces levels of Med12me2a and H3R2me2a in HEK293 cells. MS049 dihydrochloride is not toxic and does not affect the growth of HEK293 cells .

HY-114965

TP-064 2 Publications Verification	Histone Methyltransferase	Inflammation/Immunology Cancer
TP-064 is a potent and selective *proteinarginine methyltransferase 4 (PRMT4; CARM1)* inhibitor (IC₅₀ <10 nM). TP-064 inhibits dimethylation of BAF155 (IC₅₀ of 340 nM) and MED12 (IC₅₀ of 43 nM). TP-064 is inactive against the other family members except for PRMT6 (IC₅₀ of 1.3 μM). TP-064 has anticancer activities .

HY-128717

GSK3368715 EPZ019997	Histone Methyltransferase	Cancer
GSK3368715 (EPZ019997) is an orally active, reversible, and S-adenosyl-L-methionine (SAM) uncompetitive type I protein arginine methyltransferases (PRMTs) inhibitor (IC₅₀=3.1 nM (PRMT1), 48 nM (PRMT3), 1148 nM (PRMT4), 5.7 nM (PRMT6), 1.7 nM (PRMT8)). GSK3368715 (EPZ019997) produces a shift in arginine methylation states, alters exon usage, and has strong anti-cancer activity .

HY-128717A

GSK3368715 dihydrochloride Maximum Cited Publications 11 Publications Verification EPZ019997 dihydrochloride	Histone Methyltransferase	Cancer
GSK3368715 dihydrochloride (EPZ019997 dihydrochloride) is an orally active, reversible, and S-adenosyl-L-methionine (SAM) uncompetitive type I protein arginine methyltransferases (PRMTs) inhibitor (IC₅₀=3.1 nM (PRMT1), 48 nM (PRMT3), 1148 nM (PRMT4), 5.7 nM (PRMT6), 1.7 nM (PRMT8)). GSK3368715 dihydrochloride (EPZ019997 dihydrochloride) produces a shift in arginine methylation states, alters exon usage, and has strong anti-cancer activity .

HY-128717B

GSK3368715 trihydrochloride EPZ019997 trihydrochloride	Histone Methyltransferase	Cancer
GSK3368715 trihydrochloride (EPZ019997) is an orally active, reversible, and S-adenosyl-L-methionine (SAM) uncompetitive type I protein arginine methyltransferases (PRMTs) inhibitor (IC₅₀=3.1 nM (PRMT1), 48 nM (PRMT3), 1148 nM (PRMT4), 5.7 nM (PRMT6), 1.7 nM (PRMT8)). GSK3368715 trihydrochloride (EPZ019997) produces a shift in arginine methylation states, alters exon usage, and has strong anti-cancer activity .

HY-110137A

Furamidine DB75; NSC 305831	Histone Methyltransferase Phosphodiesterase (PDE) Parasite	Infection Inflammation/Immunology Cancer
Furamidine (DB75) is a selective protein arginine methyltransferase 1 (PRMT1) inhibitor with an IC₅₀ of 9.4 μM. Furamidine is selective for *PRMT1* over PRMT5, PRMT6, and PRMT4 (CARM1) (IC₅₀s of 166 µM, 283 µM, and >400 µM, respectively). Furamidine is a potent, reversible and competitive tyrosyl-DNA phosphodiesterase 1 (TDP-1) inhibitor. Inhibition of TDP-1 by Furamidine is effective both with single- and double-stranded DNA substrates but is slightly stronger with the duplex DNA. Furamidine is also an antiparasite agent .

HY-110137

Furamidine dihydrochloride 1 Publications Verification DB75 dihydrochloride; NSC 305831 dihydrochloride	Histone Methyltransferase Phosphodiesterase (PDE) Parasite	Infection Inflammation/Immunology Cancer
Furamidine dihydrochloride (DB75 dihydrochloride) is a selective protein arginine methyltransferase 1 (PRMT1) inhibitor with an IC₅₀ of 9.4 μM. Furamidine dihydrochloride is selective for *PRMT1* over PRMT5, PRMT6, and PRMT4 (CARM1) (IC₅₀s of 166 µM, 283 µM, and >400 µM, respectively). Furamidine dihydrochloride is a potent, reversible and competitive tyrosyl-DNA phosphodiesterase 1 (TDP-1) inhibitor. Inhibition of TDP-1 by Furamidine dihydrochloride is effective both with single- and double-stranded DNA substrates but is slightly stronger with the duplex DNA. Furamidine dihydrochloride is also an antiparasite agent .

Cat. No.	Product Name	Target	Research Area

HY-P1182

C21

Histone Methyltransferase Cancer

C21 is a potent, irreversible, and selective PRMT1 inhibitor with an IC₅₀ of 1.8 μM. C21 inhibits PRMT6 with an IC₅₀ of 8.8 μM .

C21	Histone Methyltransferase	Cancer
C21 is a potent, irreversible, and selective *PRMT1* inhibitor with an IC₅₀ of 1.8 μM. C21 inhibits PRMT6 with an IC₅₀ of 8.8 μM .

Cat. No.	Compare	Product Name	Species	Source

HY-P75983

	PRMT6 Protein, Human (HEK293, His-Flag) Protein arginine N-methyltransferase 6; PRMT6; HRMT1L6	Human	HEK293
	PRMT6, a versatile arginine methyltransferase, prefers asymmetrical dimethylarginine (aDMA) formation and methylates arginine residues within a glycine and arginine-rich domain. It orchestrates asymmetric dimethylation of histone H3 'Arg-2,' leading to H3R2me2a, a unique epigenetic tag associated with transcriptional repression. PRMT6 serves as a transcriptional repressor for various genes, including HOXA2, THBS1, and TP53, inhibiting cellular senescence by repressing TP53. It also methylates histones H2A and H4 'Arg-3,' acts as a coactivator for steroid hormone receptors, regulates alternative splicing, and plays a role in innate immunity against HIV-1. PRMT6 Protein, Human (HEK293, His-Flag) is the recombinant human-derived PRMT6 protein, expressed by HEK293, with N-Flag, C-His labeled tag. The total length of PRMT6 Protein, Human (HEK293, His-Flag) is 375 a.a., with molecular weight of 43-46 kDa.


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HY-P80875

PRMT6 Antibody (YA685) HRMT1L6; PRMT 6	WB, IHC-F, IHC-P, ICC/IF	Human
PRMT6 Antibody (YA685) is a non-conjugated and Mouse origined monoclonal antibody about 42 kDa, targeting to PRMT6 (2C3). It can be used for WB,IHC-F,IHC-P,ICC/IF assays with tag free, in the background of Human.

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