Search Result
Results for "
PROTACs
" in MedChemExpress (MCE) Product Catalog:
4912
Inhibitors & Agonists
17
Biochemical Assay Reagents
6
Isotope-Labeled Compounds
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Product Name |
Target |
Research Areas |
Chemical Structure |
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- HY-168257
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- HY-163582
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PROTACs
Ras
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Cancer
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PROTAC SOS1 degrader-7 (Example 15) is a SOS1 PROTAC degrader. PROTAC SOS1 degrader-7 has anti-tumor activity . (Pink: SOS1 ligand (HY-163583); Black: linker (HY-163584); Blue: E3 ligase ligand (HY-W454906)) .
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- HY-162835
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PROTACs
Epigenetic Reader Domain
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Cancer
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PROTAC SMARCA2/4-degrader-28 (PROTAC 1) is a PROTAC-based partial degrader of SMARCA2 and SMARCA4(Bliue: CRL2 VHL ligand (S,R,S)-AHPC (HY-125845); Black: linker (HY-159680); Pink: a SMARCA-BD ligand (+)-JQ-1 (HY-13030)) .
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- HY-153023
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PROTACs
STAT
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Cancer
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PROTAC STAT3 degrader-2 is a selective and efficacious PROTAC degrader of STAT3 protein with a DC50 of 3.54 μM in Molm-16 Cell. PROTAC STAT3 degrader-2 has the potential for cancer research . PROTAC STAT3 degrader-2 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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- HY-161173
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PROTACs
Ras
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Cancer
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PROTAC SOS1 degrader-5 (compound 4) is a potent PROTAC SOS1 degrader, with the DC50 of 13 nM. PROTAC SOS1 degrader-5 strongly inhibits NCI-H358 cells proliferation with an IC50 of 5 nM .
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- HY-152145
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PROTACs
Ras
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Cancer
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PROTAC SOS1 degrader-3 is a potent PROTAC SOS1 degrader. PROTAC SOS1 degrader-3 effectively targeted SOS1 for degradation through the ubiquitin-proteasome system .
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- HY-161882
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PROTACs
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Cancer
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PROTAC SMARCA2 degrader-8 (compound 1) is a potent SMARCA2 degrader with a DC50 of 28nM in A375 cells .
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- HY-163864
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PROTACs
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Cancer
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SMARCA2 degrader-1 (compound I-321) is a PROTAC degrader of SMARCA with DC50＜100nM (red: SMARCA inhibitor, black: linker (HY-Y1215), blue: E3 ligase ligand (HY-163927) ) .
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- HY-168225
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PROTACs
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Others
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PROTAC SMARCA2/4-degrader-35 (Ex.43) is a SMARCA2/4 degrader with a DC50 <2.5 nM. (Target ligand: HY-W874018; E3 ligand: HY-168226; linker: HY-168227; E3 ligand+linker: HY-168228)
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- HY-168638
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- HY-159454
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PROTACs
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Cancer
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SMARCA2/4-degrader-3 (compound I-433) is a PROTAC SMARCA2/4-degrader based on VH032-NH2, with a degradation potency (DC50) <100 nM in MV4-11 cells .
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- HY-169271
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PROTACs
Epigenetic Reader Domain
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Cancer
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PROTAC SMARCA2 degrader-20 (Compound I-40) is a PROTAC SMARCA2 degrader. PROTAC SMARCA2 degrader-20 has the potential for the research of cancer .
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- HY-150608
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STING
PROTACs
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Inflammation/Immunology
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PROTAC STING Degrader-1 (Compound SP23) is a STING PROTAC degrader with a DC50 of 3.2 μM. PROTAC STING Degrader-1 shwos anti-inflammatory activity .
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- HY-145737
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PROTACs
Ras
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Cancer
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PROTAC SOS1 degrader-1 is a potent PROTAC SOS1 degrader with an DC50 of 98.4 nM. PROTAC SOS1 degrader-1 shows antiproliferation activity in cancer cells with various KRAS mutations. PROTAC SOS1 degrader-1 shows antitumor effect with low toxicity .
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- HY-169269
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PROTACs
Epigenetic Reader Domain
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Cancer
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PROTAC SMARCA2 degrader-18 (Example144) is a PROTAC SMARCA2 degrader. PROTAC SMARCA2 degrader-18 has the potential for the research of non-small cell lung cancer (NSCLC) .
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- HY-169274
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PROTACs
Epigenetic Reader Domain
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Cancer
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PROTAC SMARCA2 degrader-23 (Example 1) is a potent and selective PROTAC SMARCA2 degrader, with a DC50 of <100 nM. PROTAC SMARCA2 degrader-23 has the potential for the research of cancer .
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- HY-145737A
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PROTACs
Ras
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Cancer
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PROTAC SOS1 degrader-1 (TFA) is a potent PROTAC SOS1 degrader with an DC50 of 98.4 nM. PROTAC SOS1 degrader-1 shows antiproliferation activity in cancer cells with various KRAS mutations. PROTAC SOS1 degrader-1 shows antitumor effect with low toxicity .
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- HY-162245
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PROTACs
Epigenetic Reader Domain
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Cancer
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PROTAC SMARCA2 degrader-3 is a PROTAC degrader of the SWI/SNF ATPase subunits, SMARCA2. PROTAC SMARCA2 degrader-3 has anticancer effects (WO2023244764A1; Compound 153) .
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- HY-169273
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PROTACs
SWI/SNF Complex
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Cancer
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PROTAC SMARCA2 degrader-22 (Compound 5) is a PROTAC degrader for SMARCA2 with a degradation efficacy of 94% at 100 nM. PROTAC SMARCA2 degrader-22 inhibits the proliferation of cell A549 with an EC50 < 250 nM .
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- HY-169278
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Epigenetic Reader Domain
PROTACs
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Cancer
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PROTAC SMARCA2 degrader-26 (compound 45) is a potent SMARCA2 PROTAC degrader. PROTAC SMARCA2 degrader-26 induces SMARCA2 and SMARCA4 degradation in VCaP cells with the percent degradation of 94% and 57% for SMARCA2 and SMARCA4, respectively. PROTAC SMARCA2 degrader-26 shows antiproliferative activity .
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- HY-162834
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PROTACs
Epigenetic Reader Domain
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Cancer
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PROTAC SMARCA2/4-degrader-27 (PROTAC 2) is a PROTAC-based degrader of SMARCA2 and SMARCA4. (Blue: CRL2 VHL ligand VH032-cyclopropane-F (HY-125905); Black: linker (HY-159678);Pink: a SMARCA-BD ligand 1 for PROTAC (HY-44012)) .
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- HY-169275
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PROTACs
SWI/SNF Complex
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Cancer
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PROTAC SMARCA2 degrader-24 (Compound 34) is a PROTAC degrader for SMARCA2 with a DC50 < 0.1 µM in HeLa. PROTAC SMARCA2 degrader-24 degrades SMARCA4 with a DC50 > 10 μM in HeLa .
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- HY-159494
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PROTACs
Epoxide Hydrolase
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Metabolic Disease
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sEH-degrader-1 (Compound 8) serves as an inhibitor for sEH, with IC50 values of 3.8 nM and 210 nM against hsEH and msEH respectively. sEH-degrader-1 can effectively degrade sEH in mouse liver and brown adipose tissue (Red: UC-1728 (HY-114266), black: linker (HY-W248248), Blue: Thalidomide-5-piperazine (HY-W834174)) .
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- HY-169270
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Epigenetic Reader Domain
PROTACs
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Cancer
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PROTAC SMARCA2 degrader-19 (Compound 46) is a PROTAC degrader for SMARCA2, that degrades SMARCA2 in cell A549 and MV411 with a DC50 < 100 nM. PROTAC SMARCA2 degrader-19 degrades SMARCA4 in cell MV411 with a DC50 > 1000 nM .
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- HY-153674
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PROTACs
Ras
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Cancer
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PROTAC SOS1 degrader-4 (compound 10) is a potent SOS1 degrader. PROTAC SOS1 degrader-4 shows antiproliferative activity .
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- HY-168229
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PROTACs
Epigenetic Reader Domain
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Cancer
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PROTAC SMARCA2 degrader-27 (compound 4) is a PROTAC SMARCA2 degrader. PROTAC SMARCA2 degrader-27 has the potential to be used in cancer research (blue: VHL ligand (HY-168232); black: linker, (HY-168231); pink: SMARCA2 ligand, (HY-168230)) .
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- HY-125878
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SGK3-PROTAC1
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PROTACs
SGK
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Cancer
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PROTAC SGK3 degrader-1 (SGK3-PROTAC1) is a von Hippel-Lindau ligand-based SKG3 PROTAC composed of a PEG3-C4-OBn (HY-130620) alkyl linker, an SGK3 degrader (red structure), and a VHL ligand (HY-150803, blue structure). PROTAC SGK3 degrader-1 (0.3 μM) induced 50% endogenous SGK3 degradation within 2 hours, and 80% SGK3 degradation was observed at 8 hours, accompanied by loss of phosphorylation of NDRG1 (SGK3 substrate) .
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- HY-153425
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PROTACs
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Cancer
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PROTAC SMARCA2 degrader-2 is a potent and selective SMARCA2/4 PROTAC degrader with an IC50 of <0.1 μΜ in HeLa HiBiT assay. PROTAC SMARCA2 degrader-2 is extracted from patent WO2023287787A1 and has the potential for SMARCA4-related or deficient cancer research .
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- HY-157804
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PROTACs
SARS-CoV
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Infection
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PROTAC SARS-CoV-2 Mpro degrader-1 (compound 5) is a PROTAC degrader targeting the major SARS-CoV-2 protease with broad-spectrum antiviral activity .
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- HY-153424
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Target Protein Ligand-Linker Conjugates
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Cancer
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PROTAC SMARCA2 degrader-1 (compound ex7) is a BRM2 (SMARCA2) degrader (DC50<0.1 μM). PROTAC SMARCA2 degrader-1 is also an E3 ubiquitin ligase binding linker useful in research of cancers. PROTAC SMARCA2 degrader-1 is a target protein ligand-linker conjugate .
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- HY-168246
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Epigenetic Reader Domain
PROTACs
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Cancer
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PROTAC SMARCA2 degrader-29 (Example 87) is a PROTAC SMARCA2 (BRM) degrader, with DC50 of 10-100 nM (BRM) and > 1 μM (BRG1, also known as SMARCA2) respectively .
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- HY-169279
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Epigenetic Reader Domain
PROTACs
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Cancer
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PROTAC SMARCA2/4-degrader-34 (compound 38) is a potent is a potent SMARCA2 and SMARCA4 PROTAC degrader. PROTAC SMARCA2/4-degrader-34 shows PXR binding affinity with DC50 value of 85.1 nM. PROTAC SMARCA2/4-degrader-34 decreases the protein expression of 3xFLAG-PXR. (Pink: Ligand for target protein (HY-169280); Black: Linker (HY-43048); Blue: Ligand for E3 ligase (HY-125845) .
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- HY-162747
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PROTACs
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Cancer
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PROTAC SMARCA2 degrader-17 (compound I-290) is a PROTAC degrader targeting SMARCA2; it degrades SMARCA2 proteins in A549 cells with an DC50 <100 nM, and a maximum degradation rate (Dmax%) >90 after 24 h of treatment .
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- HY-162742
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PROTACs
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Cancer
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PROTAC SMARCA2 degrader-16 (compound I-278) is a PROTAC degrader targeting SMARCA2; it degrades SMARCA2 proteins in A549 cells with an DC50 <100 nM, and a maximum degradation rate (Dmax%) >90 after 24 h of treatment .
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- HY-161636
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PROTACs
Ras
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Cancer
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PROTAC SOS1 degrader-9 (Compd 10) is a PROTAC-based SOS1 degrader (Red: SOS1 Ligand (HY-161635), Black: linker (HY-W056267), Blue: E3 ligase ligand (HY-161639)) .
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- HY-159462
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PROTACs
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Cancer
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PROTAC SMARCA2 degrader-10 (compound I-507) is a PROTAC degrader targeting SMARCA2; it degrades SMARCA2 proteins in A549 cells with an DC50 <100 nM, and a maximum degradation rate (Dmax%) >90 after 24 h of treatment .
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- HY-159450
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PROTACs
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Cancer
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PROTAC SMARCA2 degrader-6 (compound I-427) is a PROTAC degrader targeting SMARCA2; it degrades SMARCA2 proteins in A549 cells with an DC50 <100 nM, and a maximum degradation rate (Dmax%) >90 after 24 h of treatment .
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- HY-161634
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PROTACs
Ras
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Cancer
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PROTAC SOS1 degrader-8 (Compd 1) is a PROTAC-based SOS1 degrader (Red: SOS1 Ligand (HY-161635), Black: linker (HY-W056267), Blue: E3 ligase ligand (HY-161637)) .
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- HY-162746
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PROTACs
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Cancer
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PROTAC SMARCA2 degrader-9 (compound I-285) is a PROTAC degrader targeting SMARCA2; it degrades SMARCA2 proteins in A549 cells with an DC50 <100 nM, and a maximum degradation rate (Dmax%) >90 after 24 h of treatment .
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- HY-103636
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Sirtuin
PROTACs
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Cancer
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PROTAC Sirt2 Degrader-1 is a SirReal-based PROTAC, acts as a Sirt2 degrader, composed of a highly potent and isotype-selective Sirt2 inhibitor, a linker, and a bona fide Cereblon ligand for E3 ubiquitin ligase. PROTAC Sirt2 Degrader-1 shows an IC50 of 0.25 μM for Sirt2, with no effect on Sirt1/Sirt3 (IC50s>100 μM) .
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- HY-169272
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PROTACs
Epigenetic Reader Domain
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Cancer
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PROTAC SMARCA2 degrader-21 (Compound I-5) is a PROTAC degrader for SMARCA, that degrades SMARCA2 with a DC50 of 10-50 nM in A549 cell, and degrades SMARCA2 and SMARCA4 in MV411 with DC50 of <1 nM and >100 nM, respectively .
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- HY-162281
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PROTACs
Ras
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Cancer
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PROTAC SOS1 degrader-6 (compound 23) is an effective SOS1 PROTACs degrader that synergizes with KRAS G12C inhibitors . PROTAC SOS1 degrader-6 consists of the target protein ligand (red part) SOS1 Ligand intermediate-7 (HY-169371), E3 ubiquitin ligase ligand (blue part) (S,R,S)-AHPC (HY-125845), and PROTAC linker (black part) 5-Bromopentanoic acid (HY-W016456). Among them, the E3 ubiquitin ligase ligand + linker can form (S,R,S)-AHPC-CO-C4-bromine (HY-169372).
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- HY-157805
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PROTACs
SARS-CoV
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Infection
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PROTAC SARS-CoV-2 Mpro degrader-2 (Compound 6) is a potent PROTAC degrader of SARS-CoV-2 M pro. PROTAC SARS-CoV-2 Mpro degrader-2 has broad-spectrum antiviral activity against CoVs, including SARS-CoV-2 (EC50 = 10.8 μM), HCoV-OC43 (EC50 = 1.6 μM) and HCoV-229E (EC50 = 6.5 μM). PROTAC SARS-CoV-2 Mpro degrader-2 exhibits potent activity against SARS-CoV-2 in Calu-3 cells, with an EC50 of 0.89 μM .
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- HY-158036
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PROTACs
STING
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Others
Inflammation/Immunology
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PROTAC STING degrader-2 is a protein Degrader that targets Stimulator of interferon genes (STING) (DC50=0.53 μM). PROTAC STING Degrader-2 is combined with STING protein and E3 ubiquitin ligase in a covalent manner to induce the degradation of STING protein. PROTAC STING Degrader-2 can be used to investigate the role of STING in autoinflammation and autoimmune diseases (PINK: STING binder (HY-145009); Blue: VHL ligand (HY-164043); Black: linker) .
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- HY-159449
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PROTACs
Epigenetic Reader Domain
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Cancer
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PROTAC SMARCA2 degrader-5 (Compound I-425) is a PROTAC degrader for catalytic subunit of the SWI/SNF complex SMARCA2. PROTAC SMARCA2 degrader-5 degrades SMARCA2 in MV411 and in A549 with DC50 <100 nM, degrades SMARCA4 with DC50 of 100-500 nM . (Pink: Ligand for target protein (HY-159531); Black: Linker (HY-159538); Blue: Ligand for E3 ligase (S,R,S)-AHPC (HY-125845))
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- HY-163502
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PROTACs
STAT
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Cancer
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PROTAC STAT3 degrader-3 (S3D1) is a STAT3 PROTAC degrader with anticancer activity (Structural notes: (Blue: Cereblon ligand (HY-10984), Black: linker; Pink: Pentafluorobenzenesulfonamide(Me)-CH2-CONH-benzamide (HY-163526)) .
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- HY-169276
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PROTACs
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Cancer
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PROTAC SMARCA2 degrader-25 (example 86) is a potent PROTAC SMARCA2 degrader with the DC50 of ＜0.01 μM (Pink: ligand for target protein (HY-169487); Black: linker (HY-W052601); Blue: E3 ligase ligand (HY-W087383)) .
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- HY-163871
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PROTACs
Epigenetic Reader Domain
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Cancer
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PROTAC SMARCA2/4-degrader-18 (Compound I-348) is a PROTAC degrader for catalytic subunit of the SWI/SNF complex SMARCA2 and SMARCA4. PROTAC SMARCA2/4-degrader-18 degrades SMARCA2 in A549 with DC50 <100 nM, degrades SMARCA4 in MV411 with DC50 <100 nM. (Pink: Ligand for Target Protein (HY-159531); Black: Linker (HY-76547); Blue: Ligand for E3 Ligase (HY-125845))
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- HY-163870
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PROTACs
Epigenetic Reader Domain
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Cancer
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PROTAC SMARCA2/4-degrader-17 (Compound I-345) is a PROTAC degrader for catalytic subunit of the SWI/SNF complex SMARCA2 and SMARCA4. PROTAC SMARCA2/4-degrader-17 degrades SMARCA2 in A549 with DC50 <100 nM, degrades SMARCA4 in MV411 with DC50 <100 nM. (Pink: Ligand for Target Protein (HY-159545); Black: Linker (HY-W053507); Blue: Ligand for E3 Ligase (HY-125845))
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- HY-162743
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PROTACs
Epigenetic Reader Domain
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Cancer
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PROTAC SMARCA2/4-degrader-29 (Compound I-279) is a PROTAC degrader for catalytic subunit of the SWI/SNF complex SMARCA2 and SMARCA4. PROTAC SMARCA2/4-degrader-29 degrades SMARCA2 in A549 with DC50 <100 nM, degrades SMARCA4 in MV411 with DC50 <100 nM. (Pink: ligand for target protein (HY-163926); Black: linker (HY-159682); Blue: ligand for E3 ligase (HY-W382038)) .
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- HY-159451
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PROTACs
Epigenetic Reader Domain
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Cancer
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PROTAC SMARCA2 degrader-7 (Compound I-428) is a PROTAC degrader for SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A (SMARCA) SMARCA2. PROTAC SMARCA2 degrader-7 degrades SMARCA2 and SMARCA4 in MV411 with DC50 of <100 and 100-500 nM. (Pink: Ligand for target protein (HY-159542); Black: Linker (HY-159538); Blue: Ligand for E3 ligase (S,R,S)-AHPC (HY-125845))
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- HY-163868
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PROTACs
Epigenetic Reader Domain
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Cancer
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PROTAC SMARCA2/4-degrader-15 (Compound I-335) is a PROTAC degrader for catalytic subunit of the SWI/SNF complex SMARCA2 and SMARCA4. PROTAC SMARCA2/4-degrader-15 degrades SMARCA2 in A549 with DC50 <100 nM, degrades SMARCA4 in MV411 with DC50 <100 nM. (Pink: Ligand for Target Protein (HY-159545); Black: Linker (HY-N3024); Blue: Ligand for E3 Ligase (HY-125845))
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- HY-159459
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PROTACs
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Cancer
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PROTAC SMARCA2/4-degrader-32 (compound I-446) is a PROTAC degrader targeting SMARCA2 and SMARCA4; it degrades SMARCA2/4 proteins in A549 cells with the DC50s <100 nM, and the maximum degradation rate (Dmax%) >90 after 24 h of treatment .
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- HY-163869
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PROTACs
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Cancer
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PROTAC SMARCA2/4-degrader-16 (compound I-337) is a PROTAC degrader targeting SMARCA2 and SMARCA4; it degrades SMARCA2/4 proteins in A549 cells with the DC50s <100 nM, and the maximum degradation rate (Dmax%) >90 after 24 h of treatment .
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- HY-162741
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PROTACs
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Cancer
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PROTAC SMARCA2/4-degrader-33 (compound I-277) is a PROTAC degrader targeting SMARCA2 and SMARCA4; it degrades SMARCA2/4 proteins in A549 cells with the DC50s <100 nM, and the maximum degradation rate (Dmax%) >90 after 24 h of treatment .
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- HY-163877
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PROTACs
Epigenetic Reader Domain
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Cancer
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PROTAC SMARCA2/4-degrader-19 (Compound I-412) is a PROTAC degrader for catalytic subunit of the SWI/SNF complex SMARCA2 and SMARCA4. PROTAC SMARCA2/4-degrader-19 degrades SMARCA2 in MV411 and in A549 with DC50 <100 nM, degrades SMARCA4 in MV411 with DC50 <100 nM. (Pink: Ligand for Target Protein (HY-163949); Black: Linker (HY-W006635); Blue: Ligand for E3 Ligase (HY-125845))
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- HY-163873
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PROTACs
Epigenetic Reader Domain
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Cancer
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PROTAC SMARCA2/4-degrader-20 (Compound I-405) is a PROTAC degrader for catalytic subunit of the SWI/SNF complex SMARCA2. PROTAC SMARCA2/4-degrader-20 degrades SMARCA2 in A549 and MV411 with DC50 <100 nM, degrades SMARCA4 in MV411 with DC50 of 100-500 nM. (Pink: Ligand for Target Protein (HY-159545); Black: Linker (HY-W006635); Blue: Ligand for E3 Ligase (HY-163932))
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- HY-159461
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PROTACs
Epigenetic Reader Domain
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Cancer
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PROTAC SMARCA2/4-degrader-9 (Compound I-503) is a PROTAC degrader for catalytic subunit of the SWI/SNF complex SMARCA2 and SMARCA4. PROTAC SMARCA2 degrader-9 degrades SMARCA2 in MV411 and in A549 with DC50 <100 nM, degrades SMARCA4 in MV411 with DC50 <100 nM . (Pink: Ligand for target protein (HY-159545); Black: Linker (HY-W006635); Blue: Ligand for E3 ligase (S,R,S)-AHPC (HY-125845))
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- HY-162748
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PROTACs
Epigenetic Reader Domain
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Cancer
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PROTAC SMARCA2/4-degrader-30 (Compound I-291) is a PROTAC degrader for catalytic subunit of the SWI/SNF complex SMARCA2 and SMARCA4. PROTAC SMARCA2/4-degrader-30 degrades SMARCA2 in A549 and in MV411 with DC50 <100 nM, degrades SMARCA4 in MV411 with DC50 <100 nM. (Pink: ligand for target protein (HY-163926); Black: linker (HY-159684); Blue: ligand for E3 ligase (HY-W382038)) .
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- HY-168236
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PROTACs
Epigenetic Reader Domain
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Cancer
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PROTAC SMARCA2 degrader-28 (Compound 158) is a PROTAC degrader for SMARCA2, that degrades SMARCA2 with a DC50 of 3 nM in HiBiT A549 cells. (Pink: Ligand for target protein (HY-168237); Black: Linker (HY-168238); Blue: Ligand for E3 ligase (HY-W087383))
|
-
- HY-161654
-
|
|
PROTACs
Ras
|
Cancer
|
|
PROTAC SOS1 degrader-10 (Compound 11o) is a degrader for son of sevenless 1 (SOS1) in a CRBN and proteasome dependent manner. PROTAC SOS1 degrader-10 degrades SOS1 in KRAS mutant cancer cells SW620, A549 and DLD-1, with DC50s of 2.23, 1.85 and 7.53 nM, respectively. PROTAC SOS1 degrader-10 inhibits the proliferations of cells SW620, A549 and DLD-1, with IC50s of 36.7, 52.2 and 107 nM, respectively. PROTAC SOS1 degrader-10 inhibits phosphorylation of ERK. (Pink: SOS1 ligand (HY-161655); Black: linker (HY-161656); Blue: E3 ligase ligand (HY-W249500))
|
-
- HY-159455
-
|
|
PROTACs
Epigenetic Reader Domain
|
Cancer
|
|
PROTAC SMARCA2/4-degrader-4 (Compound I-434) is a PROTAC degrader for catalytic subunit of the SWI/SNF complex SMARCA2 and SMARCA4. PROTAC SMARCA2/4-degrader-4 degrades SMARCA2 in MV411 and in A549 with DC50 <100 nM, degrades SMARCA4 in MV411 with DC50 <100 nM. (Pink: Ligand for target protein (HY-159472); Black: Linker (HY-159478); Blue: Ligand for E3 ligase (S,R,S)-AHPC (HY-125845))
|
-
- HY-159456
-
|
|
PROTACs
Epigenetic Reader Domain
|
Cancer
|
|
PROTAC SMARCA2/4-degrader-5 (Compound I-437) is a PROTAC degrader for catalytic subunit of the SWI/SNF complex SMARCA2 and SMARCA4. PROTAC SMARCA2/4-degrader-5 degrades SMARCA2 in MV411 and in A549 with DC50 <100 nM, degrades SMARCA4 in MV411 with DC50 of 100-500 nM. (Pink: Ligand for target protein (HY-159545); Black: Linker (HY-159557); Blue: Ligand for E3 ligase (S,R,S)-AHPC (HY-125845))
|
-
- HY-159460
-
|
|
PROTACs
Epigenetic Reader Domain
|
Cancer
|
|
PROTAC SMARCA2/4-degrader-8 (Compound I-502) is a PROTAC degrader for catalytic subunit of the SWI/SNF complex SMARCA2. PROTAC SMARCA2/4-degrader-8 degrades SMARCA2 with DC50 <100 nM in A549 and in MV411, degrades SMARCA4 with DC50<100 nM in MV411(Pink: Ligand for target protein (HY-159545); Black: Linker (HY-W063924); Blue: Ligand for E3 ligase (S,R,S)-AHPC (HY-125845))
|
-
- HY-162815
-
|
|
PROTACs
Epigenetic Reader Domain
|
Cancer
|
|
PROTAC SMARCA2/4-degrader-26 (compound 6) is a PROTAC targeting SMARCA2/4. SMARCA2 and SMARCA4 are genes and cancer targets with complementary functions that catalyze nucleosome movement. PROTAC SMARCA2/4-degrader-25 is composed of PROTAC target protein ligand 2-(4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperazin-1-yl)acetic acid (HY-46618) (red part), E3 ligase ligand (2S,4R)-4-Hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide (HY-W998248) (blue part), PROTAC linker (S)-2-Amino-3,3-dimethylbutanoic acid (HY-59140) (black part), and the conjugate composed of E3 ubiquitin ligase ligand + Linker is (S,R,S)-AHPC (HY-125845) [1] .
|
-
- HY-162813
-
|
|
PROTACs
Epigenetic Reader Domain
|
Cancer
|
|
PROTAC SMARCA2/4-degrader-25 (compound 7d) is a PROTAC targeting SMARCA2/4. PROTAC SMARCA2/4-degrader-25 is composed of E3 ligase (2S,4R)-4-Hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide (HY-W998248) (blue part), PROTAC Linker (S)-2-Amino-3,3-dimethylbutanoic acid (HY-59140) (black part), and target protein ligand SMARCA2/4-ligand-3 (HY-162814) (red part). The conjugate of E3 ubiquitin ligase ligand + Linker is (S,R,S)-AHPC (HY-125845) [1] .
|
-
- HY-159457
-
|
|
PROTACs
Epigenetic Reader Domain
|
Cancer
|
|
PROTAC SMARCA2/4-degrader-6 (compound I-438) is a SMARCA2/4 degrader. PROTAC SMARCA2/4-degrader-6 has the potential for the research of cancer. (Pink: SMARCA2/4 ligand, (HY-159545); Black: linker (HY-W006635); Blue: VHL ligand (HY-112078)) .
|
-
- HY-163872
-
|
|
PROTACs
Epigenetic Reader Domain
|
Cancer
|
|
PROTAC SMARCA2/4-degrader-10 (compound I-399) is a potent SMARCA2 degrader with an DC50 value of ＜100 nM. PROTAC SMARCA2/4-degrader-10 has the potential for the research of cancer (Blue:SMARCA2/4 ligand, (HY-159542); Black: linker (HY-W088435); Pink:VHL ligand (HY-125845)) .
|
-
- HY-168234
-
|
|
PROTACs
Epigenetic Reader Domain
|
Cancer
|
|
PROTAC SMARCA2-degrader-36 (compound 38) is a SMARCA2 degrader and can reach the the degradation rate of 99 % at the 100 nM in H929 cells. PROTAC SMARCA2-degrader-36 shows anti-proliferative activity and can be used for study of cancer(Structure Note: PINK SMARCA2 ligand HY-44012; Blue, VHL ligand (HY-112078); Black, linker HY-W014125) .
|
-
- HY-170343
-
|
|
PROTACs
SWI/SNF Complex
|
Cancer
|
|
PROTAC SMARCA2 degrader-32 (Compound 27) is the degrader for SMARCA2 with a DC50 of 1.3 nM. PROTAC SMARCA2 degrader-32 inhibits the proliferation of lung cancer cell NCI-H838 with a GI50 of 34 nM . (Pink: ligand for target protein SMARCA2 ligand-11 (HY-170349); Black: linker (HY-W895794); Blue: ligand for E3 ligase VHL (HY-170348))
|
-
- HY-162744
-
|
|
PROTACs
Epigenetic Reader Domain
|
Cancer
|
|
PROTAC SMARCA2/4-degrader-31 (Compound I-280) is a degrader for catalytic subunit of the SWI/SNF complex SMARCA2 and SMARCA4. PROTAC SMARCA2/4-degrader-31 degrades SMARCA2 in A549 with DC50 <100 nM, degrades SMARCA4 in MV411 with DC50 <100 nM. (Pink: Ligand for target protein (HY-163926); Black: Linker (HY-159682); Blue: Ligand for E3 ligase (HY-W382038)) .
|
-
- HY-170347
-
|
|
PROTACs
Epigenetic Reader Domain
|
Cancer
|
|
PROTAC SMARCA2/4 degrader-36 (Compound 29) is an effective dual degrader of SMARCA2/4,with DC50 values of 0.22 nM and 0.85 nM for SMARCA2 and SMARCA4, respectively. PROTAC SMARCA2/4 degrader-36 has anti-cell proliferation activity (Pink: Target Protein Ligand (HY-170354); Black: Linker (HY-W895794); Blue: E3 Ligase Ligand (HY-170353); E3 Ligase Ligand-Linker Conjugate (HY-170356)) .
|
-
- HY-163874
-
|
|
PROTACs
|
Cancer
|
|
SMARCA2 degrader-13 (compound I-406) is a PROTAC degrader targeting SMARCA2; it degrades SMARCA2 proteins in A549 cells with an DC50 <100 nM, and a maximum degradation rate (Dmax%) >90 after 24 h of treatment .
|
-
- HY-163866
-
|
|
PROTACs
|
Cancer
|
|
SMARCA2 degrader-3 (compound I-323) is a PROTAC degrader targeting SMARCA2; it degrades SMARCA2 proteins in A549 cells with an DC50 <100 nM, and a maximum degradation rate (Dmax%) >90 after 24 h of treatment .
|
-
- HY-163867
-
|
|
PROTACs
|
Cancer
|
|
SMARCA2 degrader-4 (compound I-332) is a PROTAC degrader targeting SMARCA2; it degrades SMARCA2 proteins in A549 cells with an DC50 <100 nM, and a maximum degradation rate (Dmax%) >90 after 24 h of treatment .
|
-
- HY-163865
-
|
|
PROTACs
|
Cancer
|
|
SMARCA2 degrader-2 (compound I-322) is a PROTAC degrader targeting SMARCA2; it degrades SMARCA2 proteins in A549 cells with an DC50 <100 nM, and a maximum degradation rate (Dmax%) >90 after 24 h of treatment .
|
-
- HY-161789
-
|
|
PROTACs
SARS-CoV
Virus Protease
|
Infection
|
|
PROTAC SARS-CoV-2 Mpro degrader-3 (Compound P2) exhibits antiviral activity through the degradation of the main protease (Mpro) of human coronaviruses (HCoVs) (DC50=27 μM). PROTAC SARS-CoV-2 Mpro degrader-3 inhibits the viral replication, with EC50 of 4.6 μM, 4.6 μM, and 0.71 μM, for human coronaviruses HCoV-229E, HCoV-OC43 and SARS-CoV-2, respectively. (Pink: ligand for target protein Mpro ligand 2 (HY-161791); Black: linker (HY-161792); Blue: ligand for E3 ligase (S,R,S)-AHPC (HY-125845)) .
|
-
- HY-163875
-
|
|
PROTACs
|
Cancer
|
|
SMARCA2 degrader-14 (compound I-408) is a PROTAC degrader targeting SMARCA2 and SMARCA4; it degrades SMARCA2/4 proteins in A549 cells with the DC50s <100 nM, and the maximum degradation rate (Dmax%) >90 after 24 h of treatment .
|
-
- HY-163876
-
|
|
PROTACs
|
Cancer
|
|
SMARCA2 degrader-15 (compound I-409) is a PROTAC degrader targeting SMARCA2 and SMARCA4; it degrades SMARCA2/4 proteins in A549 cells with the DC50s <100 nM, and the maximum degradation rate (Dmax%) >90 after 24 h of treatment .
|
-
- HY-159458
-
|
|
PROTACs
|
Cancer
|
|
SMARCA2/4-degrader-7 (compound I-439) is a PROTAC degrader targeting SMARCA2 and SMARCA4; it degrades SMARCA2/4 proteins in A549 cells with the DC50s <100 nM, and the maximum degradation rate (Dmax%) >90 after 24 h of treatment .
|
-
- HY-159452
-
|
|
PROTACs
|
Cancer
|
|
SMARCA2/4-degrader-1 (compound I-430) is a PROTAC degrader targeting SMARCA2 and SMARCA4; it degrades SMARCA2/4 proteins in A549 cells with the DC50s <100 nM, and the maximum degradation rate (Dmax%) >90 after 24 h of treatment .
|
-
- HY-159453
-
|
|
PROTACs
|
Cancer
|
|
SMARCA2/4-degrader-2 (compound I-431) is a PROTAC degrader targeting SMARCA2 and SMARCA4; it degrades SMARCA2/4 proteins in A549 cells with the DC50s <100 nM, and the maximum degradation rate (Dmax%) >90 after 24 h of treatment .
|
-
- HY-107453
-
|
PROTAC Sirt2-binding moiety 1
|
Ligands for Target Protein for PROTAC
|
Cancer
|
|
SirReal1-O-propargyl is a selective and highly potent Sirtuin 2 (Sirt2) inhibitor, with an IC50 of 2.4 μM. SirReal1-O-propargyl, the SirReal1-based moiety, binds to the cereblon ligand via a linker to form PROTAC to degrade Sirt2 . SirReal1-O-propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
-
- HY-159018
-
|
|
PROTAC Linkers
|
Cancer
|
|
Alkyne-C6-OMs is a PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-168311
-
|
|
Ligands for Target Protein for PROTAC
|
Cancer
|
|
PROTAC IRAK4 ligand-5 is a PROTAC target protein ligand (Ligands for Target Protein for PROTACs). PROTAC IRAK4 ligand-5 can be utilized for the synthesis of KT-413 (HY-153368) .
|
-
- HY-169978
-
-
- HY-134711A
-
|
|
PROTAC Linkers
|
Cancer
|
|
Amine-PEG6-thiol hydrochloride is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-161020
-
|
|
PROTAC Linkers
|
Others
|
|
m-PEG12-Ots is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-W190966
-
|
|
PROTAC Linkers
|
Others
|
|
t-Boc-Aminooxy-PEG4-t-butyl ester is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
|
-
- HY-170354
-
|
|
Ligands for Target Protein for PROTAC
|
Cancer
|
|
SMARCA2/4-ligand-4 is a PROTAC target protein ligand (Ligands for Target Protein for PROTACs). SMARCA2/4-ligand-4 can be used for the synthesis of PROTAC SMARCA2/4 degrader-36 (HY-170347) .
|
-
- HY-W442085
-
|
|
PROTAC Linkers
|
Cancer
|
|
1,4-Di(3-hydroxypropoxy)butane is the linker of PROTAC Aster-A degrader-1 (HY-D233) and can be used for the synthesis of PROTAC .
|
-
- HY-163526
-
-
- HY-168388
-
|
|
PROTAC Linkers
|
Cancer
|
|
Piperidine-C2-piperazine-Boc is a PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-130662
-
|
|
PROTAC Linkers
|
Cancer
|
|
Hydroxy-PEG8-Boc is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
|
-
- HY-139304
-
-
- HY-48932
-
-
- HY-49421
-
|
|
Ligands for Target Protein for PROTAC
|
Cancer
|
|
BTK ligand 12 is a PROTAC target protein ligand (Ligands for Target Protein for PROTACs). BTK ligand 12 can serve as an active control for the target protein ligand of NRX-0492 (HY-153357) .
|
-
- HY-49393
-
-
- HY-130416
-
|
|
PROTAC Linkers
|
Cancer
|
|
Mal-PEG2-PFP ester is a Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs.
|
-
- HY-170348
-
|
|
Ligands for E3 Ligase
|
Cancer
|
|
(S)-(S,R,S,R)-AHPC-Me-N3 serves as the E3 ligase ligand for PROTAC SMARCA2 degrader-32 (HY-170343) and can be used in the synthesis of PROTACs .
|
-
- HY-172117
-
|
|
PROTAC Linkers
|
Cancer
|
|
Boc-methylglycine-C2-bromine is a PROTAC linker.Boc-methylglycine-C2-bromine can be used to synthesize PROTAC molecules like PROTAC SMARCA2 degrader-24 (HY-169275) .
|
-
- HY-130404
-
|
|
PROTAC Linkers
|
Cancer
|
|
m-PEG3-Boc is a PEG- and Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs .
|
-
- HY-168289
-
|
|
PROTAC Linkers
|
Others
|
|
12-((4-Bromobutyl)amino)dodecanoic acid is the PROTAC linker of MS934 (HY-153863). 12-((4-Bromobutyl)amino)dodecanoic acid can be utilized in PROTAC synthesis .
|
-
- HY-169988
-
|
|
Ligands for Target Protein for PROTAC
|
Cancer
|
|
BRD9 ligand-5 (Compound 172-11) is a PROTAC target protein ligand (Ligands for Target Protein for PROTACs). BRD9 ligand-5 can be utilized for the synthesis of CFT8634 (HY-145925B) .
|
-
- HY-30756
-
|
|
PROTAC Linkers
|
Others
|
|
tert-Butyl 2,7-diazaspiro[3.5]nonane-2-carboxylate is a PROTAC linker. tert-Butyl 2,7-diazaspiro[3.5]nonane-2-carboxylate is the linker of PROTAC ER Degrader-12 (HY-160264) and PROTAC AR Degrader-9 (HY-170332) .
|
-
![tert-Butyl 2,7-diazaspiro[3.5]nonane-2-carboxylate](//file.medchemexpress.com/product_pic/hy-30756.gif)
- HY-130500
-
|
|
PROTAC Linkers
|
Cancer
|
|
Br-PEG3-CH2COOH (compound 28) is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
|
-
- HY-163788
-
|
|
PROTAC Linkers
|
Others
|
|
C5-CONH-C2-N-CH3 is a PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-130536
-
|
|
PROTAC Linkers
|
Cancer
|
|
Br-PEG4-CH2-Boc is a PEG- and Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs .
|
-
- HY-130520
-
|
|
PROTAC Linkers
|
Cancer
|
|
Bromoacetamido-PEG4-C2-Boc is a PEG- and Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs .
|
-
- HY-163152
-
-
- HY-163903
-
|
|
PROTAC Linkers
|
Cancer
|
|
OH-C2-PEG3-NHCO-C3-COOH is a PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-159947
-
|
|
PROTACs
Btk
|
Cancer
|
|
PROTAC BTK Degrader-11 is a PROTAC degrader that can break down BTK, with a DC50 of 1.7 nM. PROTAC BTK Degrader-11 can be used in cancer research. (Pink: target protein ligand (HY-159956); Black: linker; Blue: E3 ligase (HY-150839)) .
|
-
- HY-146368
-
|
|
PROTACs
VEGFR
|
Cancer
|
|
PROTAC VEGFR-2 degrader-1（PROTAC-1）, a PROTAC VEGFR-2 degrader, exhibits little VEGFR-2 inhibition (IC50> 1 μM) and anti-proliferative activity against EA.hy926 cells (IC50> 100 μM) .
|
-
- HY-146369
-
|
|
PROTACs
VEGFR
|
Cancer
|
|
PROTAC VEGFR-2 degrader-2（PROTAC-4）, a PROTAC VEGFR-2 degrader, exhibits little VEGFR-2 inhibition (IC50> 1 μM) and anti-proliferative activity against EA.hy926 cells (IC50> 100μM) .
|
-
- HY-145073
-
|
|
PROTACs
Estrogen Receptor/ERR
|
Cancer
|
|
PROTAC ER Degrader-10 is a potent PROTAC ER degrader and can be used for cancer research. PROTAC ER Degrader-10 is extracted from patent WO2021133886, example 36.
|
-
- HY-168231
-
|
|
PROTAC Linkers
|
Cancer
|
|
trans-Boc-Piperidine-C-PIP-O-cyclobutane-OH is a PROTAC linker. trans-Boc-Piperidine-C-PIP-O-cyclobutane-OH can be used to synthesize PROTAC SMARCA2 degrader-27 (HY-168229) .
|
-
- HY-168611
-
-
- HY-169482
-
-
- HY-156591
-
|
|
PROTACs
Mixed Lineage Kinase
|
Others
|
|
PROTAC MLKL Degrader-1 (Compound 36) is a PROTAC degrader of MLKL, with a Dmax ＞90%. PROTAC MLKL Degrader-1 contains modified CRBN ligands, linker and Lenalidomide (HY-A0003)-linker fragments. PROTAC MLKL Degrader-1 abrogates cell death in a TSZ model of necroptosis.
|
-
- HY-140736A
-
|
|
Liposome
|
Others
|
|
DSPE-PEG-Biotin, MW 1000 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-124011
-
|
|
PROTAC Linkers
|
Cancer
|
|
m-PEG3-aldehyde is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
|
-
- HY-140736B
-
-
- HY-140341A
-
|
|
PROTAC Linkers
|
Others
|
|
Sulfo-NHS-Acetate sodium is an alkyl chain-based PROTAC linker. Sulfo-NHS-Acetate sodium can be used in the synthesis of PROTACs .
|
-
- HY-130641
-
|
|
PROTAC Linkers
|
Cancer
|
|
Br-C10-methyl ester is a PROTAC linker, which refers to the alkyl/ether composition. Br-C10-methyl ester is used in the synthesis of a series of PROTACs (MS432). PROTACs contain two different ligands connected by a linker; one is the VHL ligand portion and the other is for the target protein .
|
-
- HY-163904
-
|
|
E3 Ligase Ligand-Linker Conjugates
|
Others
|
|
(S,R,R)-VH032-CO-C3-CONH-C2-PEG3-OH is an E3 ligase ligand-linker conjugate of PROTAC NCOA4 degrader-1 (HY-163897), which can be used for the synthesis of PROTACs .
|
-
- HY-140204
-
|
|
PROTAC Linkers
|
Cancer
|
|
Amino-PEG9-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-141399
-
|
|
PROTAC Linkers
|
Cancer
|
|
m-PEG10-Boc is a PEG-based PROTAC linker can be used in the synthesis of PROTACs .
|
-
- HY-141222
-
|
|
PROTAC Linkers
|
Cancer
|
|
m-PEG16-alcohol is a PEG-based PROTAC linker can be used in the synthesis of PROTACs .
|
-
- HY-141400
-
|
|
PROTAC Linkers
|
Cancer
|
|
m-PEG12-Boc is a PEG-based PROTAC linker can be used in the synthesis of PROTACs .
|
-
- HY-141408
-
|
|
PROTAC Linkers
|
Cancer
|
|
m-PEG5-triethoxysilane is a PEG-based PROTAC linker can be used in the synthesis of PROTACs .
|
-
- HY-130568
-
|
|
PROTAC Linkers
|
Cancer
|
|
Mal-PEG1-PFP ester is a Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs.
|
-
- HY-141224
-
|
|
PROTAC Linkers
|
Cancer
|
|
m-PEG23-alcohol is a PEG-based PROTAC linker can be used in the synthesis of PROTACs .
|
-
- HY-130589
-
|
|
PROTAC Linkers
|
Cancer
|
|
Bromo-PEG2-bromide is a PEG-based PROTAC linker can be used in the synthesis of PROTACs .
|
-
- HY-141398
-
|
Methyl-PEG9-t-butyl ester
|
PROTAC Linkers
|
Cancer
|
|
m-PEG9-Boc is a PEG-based PROTAC linker can be used in the synthesis of PROTACs .
|
-
- HY-135796
-
|
|
PROTAC Linkers
|
Cancer
|
|
m-PEG3-alcohol is a?PEG-based PROTAC linker?can be used in the synthesis of PROTACs.
|
-
- HY-140360
-
|
|
PROTAC Linkers
|
Cancer
|
|
m-PEG10-Tos is a PEG-based PROTAC linker can be used in the synthesis of PROTACs .
|
-
- HY-140398
-
|
|
PROTAC Linkers
|
Cancer
|
|
m-PEG3-Aminooxy is a PEG-based PROTAC linker can be used in the synthesis of PROTACs .
|
-
- HY-141403
-
|
|
PROTAC Linkers
|
Cancer
|
|
m-PEG37-hydrazide is a PEG-based PROTAC linker can be used in the synthesis of PROTACs .
|
-
- HY-141376
-
|
|
PROTAC Linkers
|
Cancer
|
|
m-PEG6-Br is a PEG-based PROTAC linker can be used in the synthesis of PROTACs .
|
-
- HY-141401
-
|
|
PROTAC Linkers
|
Cancer
|
|
m-PEG13-Boc is a PEG-based PROTAC linker can be used in the synthesis of PROTACs .
|
-
- HY-141219
-
|
|
PROTAC Linkers
|
Cancer
|
|
m-PEG11-OH is a PEG-based PROTAC linker can be used in the synthesis of PROTACs .
|
-
- HY-141223
-
|
|
PROTAC Linkers
|
Cancer
|
|
m-PEG19-alcohol is a PEG-based PROTAC linker can be used in the synthesis of PROTACs .
|
-
- HY-141221
-
|
|
PROTAC Linkers
|
Cancer
|
|
m-PEG15-alcohol is a PEG-based PROTAC linker can be used in the synthesis of PROTACs .
|
-
- HY-141375
-
|
|
PROTAC Linkers
|
Cancer
|
|
m-PEG5-Br is a PEG-based PROTAC linker can be used in the synthesis of PROTACs .
|
-
- HY-141402
-
|
|
PROTAC Linkers
|
Cancer
|
|
m-PEG4-Hydrazide is a PEG-based PROTAC linker can be used in the synthesis of PROTACs .
|
-
- HY-141396
-
|
|
PROTAC Linkers
|
Cancer
|
|
m-PEG5-Boc is a PEG-based PROTAC linker can be used in the synthesis of PROTACs .
|
-
- HY-168552
-
|
|
PROTAC Linkers
|
Cancer
|
|
3-Hydroxyazetidine-Cyclohexanol is a PROTAC linker that can be used in the synthesis of ALK PROTAC (HY-168551) .
|
-
- HY-168226
-
|
|
Ligands for E3 Ligase
|
Others
|
|
E3 ligase Ligand 34 is the E3 ligase ligand part of PROTAC SMARCA2/4-degrader-35 (HY-168225) and can be utilized in the synthesis of PROTACs .
|
-
- HY-141112
-
|
|
PROTAC Linkers
|
Cancer
|
|
m-PEG3-succinimidyl carbonate is a PEG-based PROTAC linker can be used in the synthesis of PROTACs .
|
-
- HY-149678
-
|
|
PROTACs
|
Cancer
|
|
PROTAC eDHFR Degrader-1 is a PROTAC that is effective degradation of eDHFR-YFP, various POIs-including YFP and Luciferase .
|
-
- HY-130619
-
|
|
PROTAC Linkers
|
Cancer
|
|
Boc-C1-PEG3-C4-OBn (PROTAC Linker 15) is a PROTAC linker, which refers to the PEG composition. Boc-C1-PEG3-C4-OBn can be used in the synthesis of a series of PROTACs, such as PROTAC SGK3 degrader-1 (HY-125878). PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins .
|
-
- HY-162241
-
|
|
PROTACs
|
Others
|
|
SJH1-62B is a proteolysis targeting chimera (PROTAC) that can target the androgen receptor (AR) .
|
-
- HY-157763
-
-
- HY-156383
-
|
|
PROTAC Linkers
|
Cancer
|
|
SCO-PEG3-NHS is a PEG linker with a terminal imine(NH) group. SCO-PEG3-NHS is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
|
-
- HY-42617
-
|
|
PROTAC Linkers
|
Cancer
|
|
Hydroxy-PEG4-CH2-Boc is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
|
-
- HY-157577
-
-
- HY-140507
-
|
|
PROTAC Linkers
|
Cancer
|
|
m-PEG4-CH2-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs .
|
-
- HY-145484
-
-
- HY-140001
-
|
|
PROTAC Linkers
|
Cancer
|
|
Amino-PEG3-C2-sulfonic acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-130599
-
|
|
PROTAC Linkers
|
Cancer
|
|
Hydroxy-PEG2-CH2-Boc is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs.
|
-
- HY-169992
-
|
|
PROTAC Linkers
|
Others
|
|
1-Bromo-4-(ethynyloxy)butane is the PROTAC linker of ACBI3 (HY-157228) and can be used in the synthesis of PROTACs .
|
-
- HY-141407
-
|
|
PROTAC Linkers
|
Cancer
|
|
m-PEG3-amido-C3-triethoxysilane is a PEG-based PROTAC linker can be used in the synthesis of PROTACs .
|
-
- HY-168726
-
|
|
PROTAC Linkers
|
Cancer
|
|
Octane-1,8-diamine-Glycolic acid is a PROTAC linker that can be used to synthesize PROTAC molecules (HY-168725) for research in the cancer .
|
-
- HY-75578
-
-
- HY-W010642
-
|
4-Pentyn-1-ol
|
PROTAC Linkers
|
Cancer
|
|
Pent-4-yn-1-ol is a PROTAC linker. Pent-4-yn-1-ol can be used to synthesize PROTAC molecules (e.g. RD-23 (HY-168867)) .
|
-
- HY-168232
-
-
- HY-130334
-
|
|
PROTAC Linkers
|
Cancer
|
|
Mal-PEG8-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
|
-
- HY-126959
-
|
|
PROTAC Linkers
|
Cancer
|
|
Biotin-PEG4-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTAC.
|
-
- HY-133176
-
|
|
PROTAC Linkers
|
Cancer
|
|
Biotin-PEG6-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTAC.
|
-
- HY-126962
-
|
|
PROTAC Linkers
|
Cancer
|
|
Mal-PEG5-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
|
-
- HY-126961
-
|
|
PROTAC Linkers
|
Cancer
|
|
Mal-PEG4-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
|
-
- HY-126963
-
|
|
PROTAC Linkers
|
Cancer
|
|
Mal-PEG6-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
|
-
- HY-112811
-
|
|
PROTACs
CDK
|
Cancer
|
|
PROTAC CDK9 degrader-2 (compound 11c) is a potent and selective CDK9 degrader based on PROTAC, with an IC50 of 17 μM in MCF-7 cell lines. Natural product Wogonin (CDK ligand) binds ubiquitin E3 ligase Cereblon (CRBN) via a linker to form PROTAC .
|
-
- HY-143458
-
|
|
FAK
PROTACs
|
Cancer
|
|
FAK PROTAC B5 (Compound B5) is a FAK PROTAC degrader with an IC50 value of 14.9 nM. FAK PROTAC B5 presents strong FAK degradation activity, antiproliferative activity, outstanding plasma stability and moderate membrane permeability. FAK PROTAC B5 inhibits cell migration and invasion .
|
-
- HY-115729A
-
-
- HY-23167
-
|
|
PROTAC Linkers
|
Cancer
|
|
Acid-PEG4-C2-Boc is a PEG- and Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs for the inhibition of mTOR .
|
-
- HY-155393
-
-
- HY-W014099
-
|
|
PROTAC Linkers
|
Cancer
|
|
Boc-NH-C4-acid is a PROTAC linker, which belongs to a Alkyl/ether linker. Boc-NH-C4-acid can be used in the synthesis of the compound PROTAC1, and specifically degrades EED, EZH2, and SUZ12 in the PRC2 Complex.
|
-
- HY-130291
-
|
|
PROTAC Linkers
|
Cancer
|
|
Biotin-PEG3-NHS ester is a PEG-based PROTAC linker can be used in the synthesis of PROTAC.
|
-
- HY-130586
-
|
|
PROTAC Linkers
|
Cancer
|
|
Mal-PEG3-PFP ester is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
|
-
- HY-130290
-
|
|
PROTAC Linkers
|
Cancer
|
|
Biotin-PEG4-OH is a PEG-based PROTAC linker can be used in the synthesis of PROTAC.
|
-
- HY-133008
-
|
|
PROTAC Linkers
|
Cancer
|
|
endo-BCN-PEG3-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
|
-
- HY-135179
-
|
(+)-Biotin-PEG3-OH
|
PROTAC Linkers
|
Cancer
|
|
Biotin-PEG3-alcohol is a PEG-based PROTAC linker can be used in the synthesis of PROTAC.
|
-
- HY-126887
-
|
|
PROTAC Linkers
|
Cancer
|
|
Mal-PEG8-NHS ester is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
|
-
- HY-40178
-
|
|
PROTAC Linkers
|
Cancer
|
|
NH2-C4-NH-Boc (compound 15) is a PROTAC linker, which refers to the Alkyl/ether composition. NH2-C4-NH-Boc can be used in the synthesis of a series of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins .
|
-
- HY-168054
-
|
|
PROTACs
Ras
|
Cancer
|
|
PROTAC K-Ras Degrader-3 (compound 40) is a PROTAC degrader of K-Ras with a DC50 of ≤ 1 nM against SW620 KRAS G12D, and a GI50 of ≤ 10 nM against SW620 3D cell growth. PROTAC K-Ras Degrader-3 can be utilized in cancer research .
|
-
- HY-163372
-
|
|
MAP4K
PROTACs
|
Cancer
|
|
PROTAC HPK1 Degrader-1 (Compound B1) is a potent HPK1 degrader with DC50 value of 1.8 nM. PROTAC HPK1 Degrader-1 inhibits phosphorylation of the SLP76 protein with IC50 value of 496.1 nM. PROTAC HPK1 Degrader-1 is a bona fide HPK1-PROTAC degrader, which provided a potential tool for further HPK1 investigation in TCR signaling .
|
-
- HY-168193
-
|
|
PROTAC Linkers
|
Cancer
|
|
5-Amino-N-(3-bromopropyl)pentanamide is a PROTAC linker used in the synthesis of PROTAC TBL1X degrader-1 (HY-168190) .
|
-
- HY-169991
-
|
|
PROTAC Linkers
|
Others
|
|
1-(3,3-Difluoro-4-piperidinyl)piperazine is the PROTAC linker of CFT8634 (HY-145925B) and can be used in the synthesis of PROTACs .
|
-
- HY-160502
-
|
|
PROTACs
|
Cancer
|
|
CST967 (Compound 17) is a USP7 PROTAC degrader, and increasing the PROTAC concentration can enhance the degradation rate of USP7. CST967 can be used in cancer research .
|
-
- HY-170058
-
-
- HY-155398
-
-
- HY-155397
-
-
- HY-130560
-
|
|
PROTAC Linkers
|
Cancer
|
|
Biotin-PEG3-propionic hydrazide is a PEG-based PROTAC linker can be used in the synthesis of PROTAC.
|
-
- HY-140074
-
|
|
PROTAC Linkers
|
Cancer
|
|
endo-BCN-PEG4-Boc is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
|
-
- HY-W382009
-
|
|
PROTAC Linkers
|
Cancer
|
|
7-Azaspiro[3.5]nonane-2-ethanol is a PROTAC linker can be used in the synthesis of PROTAC, KTX-951 (HY-148290) .
|
-
![7-Azaspiro[3.5]nonane-2-ethanol](//file.medchemexpress.com/product_pic/hy-w382009.gif)
- HY-132004
-
|
|
PROTAC Linkers
|
Cancer
|
|
Tos-O-C4-NH-Boc is an alkyl ether-based PROTAC linker can be used in the synthesis of PROTACs, such as BSJ-03-204 (HY-136250) .
|
-
- HY-159733
-
-
- HY-143277
-
-
- HY-140077
-
|
|
PROTAC Linkers
|
Cancer
|
|
endo-BCN-PEG3-NH-Boc is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
|
-
- HY-135382A
-
-
- HY-161930
-
|
|
PROTACs
Ferroptosis
|
Cancer
|
|
PROTAC GPX4 degrader-3 is a potent PROTAC GPX4 degrader with a DC50 (24h) of 0.019 μM and an IC50 of 0.024 μM in HT1080 cell .
|
-
- HY-158382
-
-
- HY-161176
-
|
|
PROTACs
|
Cancer
|
|
PROTAC KRAS G12D degrader 1 is a potent, rapid, and selective degrader of protac KRAS G12D with DC 50 of 38.06 nM. PROTAC KRAS G12D degrader 1 showes significant antitumor efficacy .
|
-
- HY-161451
-
|
|
E3 Ligase Ligand-Linker Conjugates
|
Cancer
|
|
Lenalidomide nonanedioic acid is a conjugate of the E3 ligase ligand and linker of LHF418 (HY-161450). Lenalidomide nonanedioic acid can be used as a key intermediate for the synthesis of intact PROTACs molecules .
|
-
- HY-168313
-
|
|
PROTAC Linkers
|
Others
|
|
2-(2-Azaspiro[3.3]heptan-6-yl)ethanamine is the PROTAC linker of KT-413 (HY-153368) and can be used in the synthesis of PROTACs .
|
-
![2-(2-Azaspiro[3.3]heptan-6-yl)ethanamine](//file.medchemexpress.com/product_pic/hy-168313.gif)
- HY-168037
-
|
|
PROTACs
PIN1
|
Cancer
|
|
PROTAC PIN1 degrader-1 (compound D4) is a PROTAC targeting PIN1, with a DC50=1.8 nM. The GI50 of PROTAC PIN1 degrader-1 to MDA-MB-468 is >30 μM. PROTAC PIN1 degrader-1 is composed of target protein ligand PIN1 ligand-1 (HY-168038) (red part), E3 ligase ligand Thalidomide (HY-14658) (blue part), and PROTAC linker (black part) [1] .
|
-
- HY-W039197
-
|
|
PROTAC Linkers
|
Cancer
|
|
Acid-PEG4-mono-methyl ester is a PEG- and Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs .
|
-
- HY-W067489
-
|
|
PROTAC Linkers
|
Cancer
|
|
NH2-PEG1-CH2CH2-Boc is a PEG- and Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs .
|
-
- HY-W016087
-
|
|
PROTAC Linkers
|
Cancer
|
|
Monoethyl pimelate is a PROTAC linker, which refers to the alkyl/ether composition. Monoethyl pimelate can be used in the synthesis of (S,R,S)-AHPC-Me-C7 ester, a specific BCL-XL PROTAC degrader .
|
-
- HY-168238
-
|
|
PROTAC Linkers
|
Cancer
|
|
(4-(3-Bromobenzyl)piperazin-1-yl)(piperidin-4-yl)methanone is a PROTAC linker, used for the synthesis of PROTAC SMARCA2 degrader-28(HY-168236) .
|
-
- HY-130715
-
|
|
PROTAC Linkers
|
Cancer
|
|
tert-Butyl 11-aminoundecanoate (compound 6b) is a PROTAC linker, which refers to the PEG composition. tert-Butyl 11-aminoundecanoate can be used in the synthesis of a series of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins .
|
-
- HY-140067
-
|
|
PROTAC Linkers
|
Cancer
|
|
endo-BCN-PEG2-C2-NHS ester is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
|
-
- HY-168276
-
|
|
PROTAC Linkers
|
Cancer
|
|
Boc-Nonanol is a PROTAC linker. Boc-Nonanol can be used in the synthesis of PROTAC TRIB2 degrader-1 (HY-168274) .
|
-
- HY-169989
-
|
|
Ligands for E3 Ligase
|
Cancer
|
|
CRBN ligand-11 is the E3 ubiquitin ligase ligand for CFT8634 (HY-145925B). CRBN ligand-11 can be used for the synthesis of PROTACs .
|
-
- HY-401613
-
|
|
Ligands for E3 Ligase
|
Cancer
|
|
E3 ligase Ligand 43 serves as the E3 ubiquitin ligase ligand for ACBI3 (HY-157228). E3 ligase Ligand 43 can be utilized for the synthesis of PROTACs .
|
-
- HY-162106
-
|
|
Ferroptosis
PROTACs
Glutathione Peroxidase
|
Cancer
|
|
PROTAC GPX4 degrader-2 (compound 18a) is a proteolysis targeting chimeras (PROTACs) that can degrade glutathione peroxidase 4 (GPX4), with the DC50, 48h value of 1.68 μM. PROTAC GPX4 degrader-2 induces the accumulation of lipid peroxides and mitochondrial depolarization, subsequently triggering ferroptosis. PROTAC GPX4 degrader-2 has anti-proliferative effect .
|
-
- HY-168723
-
|
|
PROTAC Linkers
|
Cancer
|
|
Piperidine-C-Pip-C2-Pip-C2-OH is a PROTAC Linker that can be used to synthesize the PROTAC PARP1 degrader-3 (HY-168722) for tumor research .
|
-
- HY-42745
-
|
|
ADC Linker
PROTAC Linkers
|
Cancer
|
|
m-PEG2-Tos is a uncleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). m-PEG2-Tos is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
|
-
- HY-122725A
-
|
|
E3 Ligase Ligand-Linker Conjugates
|
Cancer
|
|
Lenalidomide-C5-NH2 is the Lenalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Lenalidomide-C5-NH2 can be connected to the ligand for protein by a linker to form PROTACs, such as MDM2 PROTAC degrader .
|
-
- HY-130470
-
|
|
PROTAC Linkers
|
Cancer
|
|
Chloroacetamido-PEG4-C2-Boc is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs.
|
-
- HY-163144
-
|
|
PROTACs
Src
|
Cancer
|
|
DAS-5-oCRBN is a selective and potent PROTAC degrader of c-Src kinase. DAS-5-oCRBN has antiproliferative activity in both c-Src-dependent cell lines .
|
-
- HY-44141
-
|
|
PROTAC Linkers
|
Cancer
|
|
tert-Butyl 3-(2-iodoethoxy)propanoate is a PROTAC linker, which refers to the PEG composition. tert-Butyl 3-(2-iodoethoxy)propanoate can be used in the synthesis of PROTAC FAK degrader 1 (HY-119932) .
|
-
- HY-133006
-
|
|
PROTAC Linkers
|
Cancer
|
|
Fluorescein-PEG5-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
|
-
- HY-113828
-
|
|
PROTAC Linkers
|
Cancer
|
|
Biotin-PEG2-C4-alkyne is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Biotin-PEG2-C4-alkyne is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
-
- HY-W007587
-
|
|
PROTAC Linkers
|
Cancer
|
|
9-Bromononanoic acid is a PROTAC linker. 9-Bromononanoic acid can be used in synthesis PROTAC FGFR1 degrader-1 (HY-170869) .
|
-
- HY-130330
-
|
|
PROTAC Linkers
|
Cancer
|
|
Ald-CH2-PEG5-Boc is a PEG- and Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs .
|
-
- HY-169072
-
|
|
PROTACs
Mixed Lineage Kinase
|
Cancer
|
|
PROTAC MLKL Degrader-2 (compound MP-1) is a PROTAC targeting MLKL (Mixed Lineage Kinase). PROTAC MLKL Degrader-2 is composed of PROTAC target protein ligand PROTAC MLKL Degrader-2 (HY-169072) (red part), E3 ligase ligand Thalidomide (HY-14658) (blue part) and PROTAC Linker N-Methylpiperazine (HY-78871) (black part), among which the conjugate of E3 ubiquitin ligase ligand + Linker is Thalidomide-N-methylpiperazine (HY-169074) [1] .
|
-
- HY-120918
-
|
|
PROTAC Linkers
|
Cancer
|
|
NH2-PEG7 is a PROTAC linker, which refers to the PEG composition. NH2-PEG7 can be used in the synthesis of the PROTAC PARP1 degrader iRucaparib-AP6 .
|
-
- HY-130490
-
|
|
PROTAC Linkers
|
Cancer
|
|
Biotin-bis-amido-SS-NHS is an Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs.
|
-
- HY-147205E
-
|
|
Fluorescent Dye
|
Others
|
|
Biotin-PEG-OH (MW 20000) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-W010764
-
|
|
PROTAC Linkers
|
Cancer
|
|
Biotin-PEG2-Mal is a PEG-based PROTAC linker can be used in the synthesis of PROTAC.
|
-
- HY-133061
-
|
|
PROTAC Linkers
|
Cancer
|
|
Fluorescein-thiourea-PEG6-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-122459
-
|
|
PROTAC Linkers
|
Cancer
|
|
Fmoc-PEG5-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-122456
-
|
|
PROTAC Linkers
|
Cancer
|
|
Fmoc-PEG4-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-126882
-
|
|
PROTAC Linkers
|
Cancer
|
|
Fmoc-PEG6-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-149236
-
-
- HY-146349
-
|
|
PROTACs
EGFR
Autophagy
|
Cancer
|
|
PROTAC EGFR degrader 4 is a potent PROTAC targeting mutant EGFR.PROTAC EGFR degrader 4 induces EGFR del19 and EGFR L858R/T790M degradation with DC50s of 0.51 and 126 nM, respectively. PROTAC EGFR degrader 4 significantly inhibits growth of HCC827 and H1975 cell lines with IC50s of 0.83 and 203.1 nM, respectively. Induced EGFR degradation is related to autophagy .
|
-
- HY-W733885
-
|
|
Ligands for E3 Ligase
|
Cancer
|
|
E3 ligase Ligand 38 serves as the E3 ligase ligand for PROTAC IRAK4 degrader-12 (HY-168586) and can be used in the synthesis of PROTACs.
|
-
- HY-135306
-
|
|
PROTAC Linkers
|
Cancer
|
|
Cl-C6-PEG4-C3-COOH is a PROTAC linker can be used in the synthesis of chloroalkane-containing PROTACs (HaloPROTACs) .
|
-
- HY-158142
-
|
|
PROTACs
JAK
|
Cancer
|
|
PROTAC TYK2 degrader-1 (CPD-155) is a PROTAC targeting degrader to TYK2 with Dmax >60%. (Structure Note: PINK, TYK2 ligand 1 (HY-158340); Blue, VHL ligand Thalidomide (HY-14658); Black, linker)
|
-
- HY-126888
-
|
|
PROTAC Linkers
|
Cancer
|
|
Mal-PEG5-NHS ester is an Alkyl/ether and PEG-based PROTAC linker can be used in the synthesis of PROTACs.
|
-
- HY-168551
-
|
|
PROTACs
Anaplastic lymphoma kinase (ALK)
|
Cancer
|
|
PROTAC ALK degrader-3 (4B) is an orally active ALK degrader based on PROTACs, which can effectively induce persistent degradation of ALK fusion protein in Karpas 299 cells and strong inhibition of downstream pathways,IC50 is 119.33 nM. PROTAC ALK degrader-3 exhibits antitumor activity. (Structure Note: PINK, ALK Inhibitor (HY-15656); Blue, E3 (HY-W023573); Black, linker (HY-168552)) .
|
-
- HY-168275
-
-
- HY-162098
-
|
|
Microtubule/Tubulin
|
Cancer
|
|
PROTAC tubulin-IN-1 (compound W13) is an inhibitor of PROTAC tubulin. PROTAC tubulin-IN-1 exhibits antitumor activity against human lung cancer .
|
-
- HY-160259
-
|
|
PROTACs
VEGFR
|
Cardiovascular Disease
|
|
VEGFR-2-IN-39 (PROTAC-5) is a PROTAC targeting VEGFR-2 (IC50: 208.6 nM). VEGFR-2-IN-39 has low toxicity.VEGFR-2-IN-39 inhibits the proliferation of EA.hy926, one of HUVECs, in a concentration-dependent manner, with an IC50 of 38.65 µM .
|
-
- HY-168228
-
|
|
E3 Ligase Ligand-Linker Conjugates
|
Others
|
|
E3 Ligase Ligand-linker Conjugate 123 is the E3 ligand-linker part of PROTAC SMARCA2/4-degrader-35 (HY-168225). E3 Ligase Ligand-linker Conjugate 123 can be utilized in the synthesis of PROTACs .
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-
- HY-141406
-
|
|
PROTAC Linkers
|
Cancer
|
|
m-PEG5-2-methylacrylate is a PEG- and Alkyl/ester-based PROTAC linker can be used in the synthesis of PROTACs .
|
-
- HY-140239
-
|
|
PROTAC Linkers
|
Cancer
|
|
Amino-PEG4-benzyl ester is a PEG- and Alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-A0023AS2
-
-
- HY-W008296
-
|
|
PROTAC Linkers
|
Cancer
|
|
NH2-C6-NH-Boc is a PROTAC linker which refers to the alkyl/ether composition. NH2-C6-NH-Boc can be used in the synthesis the Mcl-1 inhibitor based on PROTAC .
|
-
- HY-156244
-
|
|
PROTACs
|
Cancer
|
|
PROTAC GDI2 Degrader-1 (compound 21) is a potent PROTAC GDI2 degrader. PROTAC GDI2 Degrader-1 exhibits excellent in vivo antitumor activity in the GDI2-overexpressing pancreatic xenograft models .
|
-
- HY-163169
-
|
|
Ligands for E3 Ligase
|
Others
|
|
Phenyl-glutarimide 4 ’-oxyacetic acid is a carboxylic acid-functionalized cerebellar ligand that can be used in the development of PROTAC deactivators. Phenyl-glutarimide 4 ’-oxyacetic acid binds to PROTAC has better hydrolytic stability and efficacy .
|
-
- HY-W190956
-
|
|
Others
|
Cancer
|
|
(S,R,S)-AHPC-PEG4-acid is a synthetic PROTAC ligand that binds the E3 ligase ligand to the PEG4 arm, thereby enhancing PROTAC drug research and discovery .
|
-
- HY-130549
-
|
|
PROTAC Linkers
|
Cancer
|
|
Acid-PEG3-C2-Boc is a PEG- and Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs for the degradation of EGFR and inhibition of mTOR .
|
-
- HY-35261A
-
|
|
PROTAC Linkers
|
Cancer
|
|
Mal-PEG2-NH2 (TFA) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-133737
-
|
|
PROTACs
Epigenetic Reader Domain
|
Cancer
|
|
PROTAC BRD4 Degrader-5 is a PROTAC connected by ligands for von Hippel-Lindau and BRD4. PROTAC BRD4 Degrader-5 can potent degrade BRD4 in HER2 positive and negative breast cancer cell lines .
|
-
- HY-130499
-
|
|
Target Protein Ligand-Linker Conjugates
|
Cancer
|
|
ERRα Ligand-Linker Conjugates 1 incorporates a ligand for estrogen-related receptor alpha (ERRα), and a PROTAC linker, which recruit E3 ligases MDM2. ERRα Ligand-Linker Conjugates 1 can be used in the synthesis of a series of PROTACs, such as PROTAC ERRalpha Degrader-1 (HY-128838). PROTAC ERRalpha Degrader-1 is an ERRα degrader .
|
-
- HY-168702
-
-
- HY-149307
-
|
|
Ligands for E3 Ligase
|
Others
|
|
CYCA-117-70 is a DCAF1 ligand (KD: 70 μM). CYCA-117-70 is an ideal chemical handles for PROTACs recruiting DCAF1 .
|
-
- HY-400145
-
|
|
PROTAC Linkers
|
Others
|
|
mPEG45-Epoxide is a PEG derivative containing polyether units. mPEG45-Epoxide can be used to synthesize PROTAC molecules .
|
-
- HY-130695
-
|
|
PROTAC Linkers
|
Cancer
|
|
N-(Amino-PEG5)-N-bis(PEG4-acid) is a PEG-based PROTAC linker used in the synthesis of PROTACs. N-(Amino-PEG5)-N-bis(PEG4-acid) contains an amino group with two terminal carboxylic acids .
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-
- HY-140057
-
|
|
PROTAC Linkers
|
Cancer
|
|
Aminooxy-PEG3-propargyl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . Aminooxy-PEG3-propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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-
- HY-140056
-
|
|
PROTAC Linkers
|
Cancer
|
|
Aminooxy-PEG1-propargyl is a PEG-based PROTAC linker can be used in the synthesis of PROTACs . Aminooxy-PEG1-propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
-
- HY-23408
-
|
|
PROTAC Linkers
|
Cancer
|
|
Tos-PEG3 is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Tos-PEG3 (structure 1) can be used for the synthesis of 3'-aminooxy oligonucleotides solid supports .
|
-
- HY-160094
-
|
|
Ligands for Target Protein for PROTAC
|
Cancer
|
|
BCN-sulfonamide-PEG2-sulfonamide-N-bis ethanol (compound 71) is a Ligands for Target Protein for PROTAC that contains a sulfonamide linker to increase the solubility of the linker-conjugate. BCN-sulfonamide-PEG2-sulfonamide-N-bis ethanol can be used to synthesize PROTACs with antitumor activity .
|
-
- HY-140284A
-
|
|
PROTAC Linkers
|
Others
|
|
DBCO-PEG6-amine TFA is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . DBCO-PEG6-amine (TFA) is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
|
-
- HY-129939
-
-
- HY-141404
-
|
|
PROTAC Linkers
|
Cancer
|
|
m-PEG4-CH2-methyl ester is a PEG- and Alkyl/ester-based PROTAC linker can be used in the synthesis of PROTACs .
|
-
- HY-133131
-
|
|
PROTACs
Epigenetic Reader Domain
|
Cancer
|
|
PROTAC BRD4 Degrader-1 is a PROTAC connected by ligands for Cereblon and BRD4 with an IC50 of 41.8 nM against BRD4 BD1. PROTAC BRD4 Degrader-1 can effectively degrade BRD4 protein and suppress c-Myc expression .
|
-
- HY-163790
-
|
|
PROTAC Linkers
|
Others
|
|
Desthiobiotin-PEG3-sulfo-Maleimide is a PEG linker can be used in the synthesis of PROTACs .
|
-
- HY-161452
-
-
- HY-168200
-
|
|
PROTAC Linkers
|
Cancer
|
|
1-(5-Iodo-2-pyridinyl)-4-piperidinecarboxylic acid is a PROTAC linker can be used in the synthesis of DYR684 (HY-168194) .
|
-
- HY-168553
-
-
- HY-126886
-
|
|
ADC Linker
PROTAC Linkers
|
Cancer
|
|
Mal-PEG1-NHS ester is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Mal-PEG1-NHS ester is PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
|
-
- HY-111866
-
|
|
PROTACs
RIP kinase
|
Metabolic Disease
Cancer
|
|
PROTAC RIPK degraders -2 is a non-peptide PROTAC based on von Hippel-Lindau and targets serine-threonine kinase RIPK2, which is highly selective to the degradation of RIPK2. PROTAC RIPK degrader-2 acts as an activator to increase cell death and activate ion channels in cancer cells. PROTAC RIPK degrader-2 also can inhibit protein interactions, such as receptors and ligands, involved in a variety of diseases, such as cancer and diabetes .
|
-
- HY-135382
-
|
|
PROTACs
IRAK
|
Inflammation/Immunology
Cancer
|
|
PROTAC IRAK4 degrader-2 (Compound 9) is a PROTAC-based IRAK4 degrader that affords potent IRAK4 degradation with a DC50 in peripheral blood mononuclear cells (PBMCs) cells of 151 nM. PROTAC IRAK4 degrader-2 induce a reduction of IRAK4 protein levels with a DC50 of 36 nM in PBMC cells. PROTAC IRAK4 degrader-2 also leads to the inhibition of multiple cytokines in PBMCs .
|
-
- HY-131386A
-
|
|
Target Protein Ligand-Linker Conjugates
|
Cancer
|
|
BMS-1166-N-piperidine-CO-N-piperazine dihydrochloride incorporates a ligand for PD-1/PD-L1 immune checkpoint, and a PROTAC linker. BMS-1166-N-piperidine-CO-N-piperazine dihydrochloride can be used in the synthesis of PROTAC PD-1/PD-L1 degrader-1?(HY-131183). PROTAC PD-1/PD-L1 degrader-1 inhibits PD-1/PD-L1 interaction with an IC50 of 39.2 nM .
|
-
- HY-168191
-
-
- HY-140406
-
|
|
PROTAC Linkers
|
Cancer
|
|
Aminooxy-PEG3-C2-NH-Boc is a PEG- and Alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-140596
-
|
|
PROTAC Linkers
|
Cancer
|
|
m-PEG3-S-PEG3-Boc is a PEG- and Alkyl/ether -based PROTAC linker can be used in the synthesis of PROTACs .
|
-
- HY-168075
-
|
|
PROTAC Linkers
|
Others
|
|
Boc-PIP-Me-CH2-2,7-diazaspiro[3.5]nonane is the linker of PROTAC K-Ras Degrader-3 (HY-168054), which can be used in the synthesis of PROTACs .
|
-
![Boc-PIP-Me-CH2-2,7-diazaspiro[3.5]nonane](//file.medchemexpress.com/product_pic/hy-168075.gif)
- HY-W761299
-
-
- HY-161536
-
|
|
PROTACs
EGFR
Apoptosis
|
Cancer
|
|
PROTAC EGFR degrader 9 (Compound C6) is an orally active CRBN-based PROTAC EGFR degrader. PROTAC EGFR degrader 9 exhibits a DC50 of 10.2 nM and a Kd of 240.2 nM against EGFR L858R/T790M/C797S. PROTAC EGFR degrader 9 exhibits potent degradation activity against various EGFR mutants, while sparing the EGFRWT. (Blue: CRBN ligand (HY-A0003), Black: linker (HY-161613); Pink: EGFR inhibitor (HY-161537)) .
|
-
- HY-138752
-
|
|
PROTAC Linkers
|
Cancer
|
|
S-acetyl-PEG4-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-120773
-
|
|
PROTAC Linkers
|
Cancer
|
|
Fmoc-PEG3-CH2CH2-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-126881
-
|
|
PROTAC Linkers
|
Cancer
|
|
Fmoc-PEG2-CH2CH2-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-130077
-
|
|
PROTAC Linkers
|
Cancer
|
|
Fmoc-PEG1-CH2CH2-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-44824
-
-
- HY-133009
-
|
|
PROTAC Linkers
|
Cancer
|
|
BCN-PEG4-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. BCN-PEG4-acid contains a BCN group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
|
-
- HY-163961
-
|
|
E3 Ligase Ligand-Linker Conjugates
|
Cancer
|
|
(S)-Thalidomide-NH-cyclohexane-NH-Ph-NH2 (Compound C63) is the E3 ligase + linker of (HY-163938) PROTAC, which contains Thalidomide-based cereblon ligand and 1 linker and can be used for synthesis PROTAC .
|
-
- HY-169073
-
|
|
Ligands for Target Protein for PROTAC
|
Others
|
|
TC13172-NH-COOH is a PROTAC target protein ligand (Ligands for Target Protein for PROTACs). TC13172-NH-COOH can be used for synthesis PROTAC MLKL Degrader-2 (HY-169072) .
|
-
- HY-138752A
-
|
|
PROTAC Linkers
|
Cancer
|
|
S-acetyl-PEG4-amine (TFA) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-169396
-
-
- HY-129704
-
-
- HY-161805
-
|
|
Flavivirus
|
Infection
|
|
GNF-2-acid is a target protein ligand activity control that can be used for the synthesis of PROTACs (HY-161806) .
|
-
- HY-164365
-
|
|
PROTACs
Ras
|
Cancer
|
|
PROTAC K-Ras degrader-2 (compound 48) is a pan-KRAS-mutant PROTAC degrader with an IC50 of ≤200 nM for KRAS G12V/RAF1. PROTAC K-Ras degrader-2 degrades SW620 KRAS G12D with a DC50 of ≤200 nM. PROTAC K-Ras degrader-2 inhibits cell growth of SW620 3D cell with an IC50 of ≤20 nM. (Pink: KRAS inhibitor-30 (HY-164366)) .
|
-
- HY-140594
-
|
|
PROTAC Linkers
|
Cancer
|
|
m-PEG3-S-PEG4-propargyl is a PEG-based PROTAC linker can be used in the synthesis of PROTACs . m-PEG3-S-PEG4-propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
-
- HY-135309
-
|
|
PROTACs
Estrogen Receptor/ERR
|
Cancer
|
|
PROTAC ER Degrader-4 is a von Hippel-Lindau-based PROATC estrogen receptor (ER) degrader, binding to ER with an IC50 of 0.8 nM. PROTAC ER Degrader-4 induces ER degradation in MCF-7 cells with an IC50 of 0.3 nM .
|
-
- HY-130620
-
|
|
PROTAC Linkers
|
Cancer
|
|
PEG3-C4-OBn is a polyethylene glycol (PEG)-based PROTAC linker. PEG3-C4-OBn can be used in the synthesis of the PROTAC SGK3 degrader-1 (HY-125878). PROTAC SGK3 degrader-1 is a potent SKG3 degrader based on PROTAC .
|
-
- HY-129704A
-
-
- HY-130639
-
-
- HY-149845
-
|
|
GSK-3
PROTACs
|
Neurological Disease
|
|
PROTAC GSK-3β Degrader-1 (compound 1) is a degrader targets GSK-3β degradation with an IC50 value of 833 nM. PROTAC GSK-3β Degrader-1 contains SB-216763 (a GSK-3β inhibitor), a PEG linker and a CRBN (E3 ligase liand). PROTAC GSK-3β Degrader-1 reduces the neurotoxicity induced by Aβ25-35 peptide and CuSO4. PROTAC GSK-3β Degrader-1 can be used to research in Alzheimer's disease .
|
-
- HY-132991
-
|
|
PROTACs
Epigenetic Reader Domain
|
Cancer
|
|
ML 2-14 is a PROTAC targeting BRD4 with a C4 alkyl linker. ML 2-14 consists of the E3 ligase ligand EN219 (HY-115715) (bule part), the target protein ligand JQ-1 (HY-13030) (red part), and the PROTAC linker (balck part). ML 2-14 can effectively degrade BRD4 in 231MFP breast cancer cells, and this effect can be reversed by the proteasome inhibitor Bortezomib (HY-10227) and the E1 activase inhibitor TAK-243 (HY-100487) .
|
-
- HY-160694
-
|
|
PROTACs
|
Cancer
|
|
cBu-Cit-PROTAC BRD4 Degrader-5 is a cBu-Cit conjugated PROTAC degrader. cBu-Cit-PROTAC BRD4 Degrader-5 can potently degrade BRD4 in HER2 positive and negative breast cancer cell lines .
|
-
- HY-168227
-
|
|
PROTAC Linkers
|
Cancer
|
|
trans-Boronic acid pinacol-pyrazole-C-cyclobutane-O-piperidine-Boc is a PROTAC linker. trans-Boronic acid pinacol-pyrazole-C-cyclobutane-O-piperidine-Boc can be used in the synthesis of PROTAC SMARCA2/4-degrader-35 (HY-168225) .
|
-
- HY-168290
-
|
|
E3 Ligase Ligand-Linker Conjugates
|
Cancer
|
|
(S,R,S)-AHPC-Me-12-((4-Bromobutyl)amino)dodecanamide incorporates a VHL ligand for the E3 ubiquitin ligase, and a PROTAC linker. (S,R,S)-AHPC-Me-12-((4-Bromobutyl)amino)dodecanamide can be used in the synthesis of PROTACs, such as MS934 (HY-153863). MS934 is a novel improved VHL-recruiting MEK 1/2 PROTAC degrader .
|
-
- HY-169158
-
-
- HY-130554
-
|
|
PROTAC Linkers
|
Cancer
|
|
m-PEG9-phosphonic acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
|
-
- HY-141159
-
|
|
PROTAC Linkers
|
Cancer
|
|
TCO-PEG4-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs .
|
-
- HY-112559
-
|
|
PROTAC Linkers
|
Cancer
|
|
Bis-PEG2-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs .
|
-
- HY-141160
-
|
|
PROTAC Linkers
|
Cancer
|
|
TCO-PEG6-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs .
|
-
- HY-141161
-
|
|
PROTAC Linkers
|
Cancer
|
|
TCO-PEG8-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs .
|
-
- HY-120587
-
|
|
PROTAC Linkers
|
Cancer
|
|
Bis-PEG6-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs .
|
-
- HY-126891
-
|
|
PROTAC Linkers
|
Cancer
|
|
Bis-PEG3-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs .
|
-
- HY-141162
-
|
|
PROTAC Linkers
|
Cancer
|
|
TCO-PEG12-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs .
|
-
- HY-149434
-
|
|
Androgen Receptor
Apoptosis
|
Cancer
|
|
PROTAC AR-NTD antagonist 1 (compound 18) is a small molecule protein-targeting chimera (PROTACs) targeting the Androgen Receptor AR-V7. PROTAC AR-NTD antagonist 1 antagonizes the N-terminal domain of AR (AR-NTD), degrades AR-V7 protein, and induces apoptosis in prostate cancer (PC) cells. The efficiencies of PROTAC AR-NTD antagonist 1 in degrading AR-V7 in VCaP cells were 62.2% (1 μM) and 71.1% (5 μM), respectively .
|
-
- HY-159956
-
-
- HY-W043277
-
|
|
PROTAC Linkers
|
Cancer
|
|
m-PEG3-Tos is a PEG-based PROTAC linker can be used in the synthesis of Silymarin (HY-W043277) .
|
-
- HY-123961
-
|
|
PROTACs
c-Met/HGFR
|
Cancer
|
|
SJF-8240 (PROTAC 7) is a proteolysis targeting chimera (PROTAC) degrader. SJF-8240 induces polyubiquitination of c-Met and inhibits the proliferation of GTL16 cells (IC50=66.7 nM) .
|
-
- HY-164924
-
|
|
PROTACs
|
Cancer
|
|
ERD-12310A is a PROTAC targeting Estrogen Receptor α (ERα) with a ED50 value of 47 pM. ERD-12310A has oral activity. ERD-12310A is composed of PROTAC target protein ligand ER ligand-4 (HY-164925) (red part), E3 ligase ligand (S)-Deoxy-thalidomide (HY-168055) (blue part) .
|
-
- HY-141178
-
|
|
PROTAC Linkers
|
Cancer
|
|
TCO-PEG3-amine is a PEG-based PROTAC linker can be used in the synthesis of PROTACs .
|
-
- HY-141181
-
|
|
PROTAC Linkers
|
Cancer
|
|
TCO-PEG8-amine is a PEG-based PROTAC linker can be used in the synthesis of PROTACs .
|
-
- HY-141187
-
|
|
PROTAC Linkers
|
Cancer
|
|
TCO-PEG3-TCO is a PEG-based PROTAC linker can be used in the synthesis of PROTACs .
|
-
- HY-141166
-
|
|
PROTAC Linkers
|
Cancer
|
|
TCO-PEG3-NHS ester is a PEG-based PROTAC linker can be used in the synthesis of PROTACs .
|
-
- HY-141183
-
|
|
PROTAC Linkers
|
Cancer
|
|
TCO-PEG4-biotin is a PEG-based PROTAC linker can be used in the synthesis of PROTACs .
|
-
- HY-141180
-
|
|
PROTAC Linkers
|
Cancer
|
|
TCO-PEG6-amine is a PEG-based PROTAC linker can be used in the synthesis of PROTACs .
|
-
- HY-141189
-
|
|
PROTAC Linkers
|
Cancer
|
|
TCO-PEG8-TCO is a PEG-based PROTAC linker can be used in the synthesis of PROTACs .
|
-
- HY-141179
-
|
|
PROTAC Linkers
|
Cancer
|
|
TCO-PEG4-amine is a PEG-based PROTAC linker can be used in the synthesis of PROTACs .
|
-
- HY-141177
-
|
|
PROTAC Linkers
|
Cancer
|
|
TCO-PEG2-amine is a PEG-based PROTAC linker can be used in the synthesis of PROTACs .
|
-
- HY-141169
-
|
|
PROTAC Linkers
|
Cancer
|
|
TCO-PEG8-NHS ester is a PEG-based PROTAC linker can be used in the synthesis of PROTACs .
|
-
- HY-141188
-
|
|
PROTAC Linkers
|
Cancer
|
|
TCO-PEG4-TCO is a PEG-based PROTAC linker can be used in the synthesis of PROTACs .
|
-
- HY-141168
-
|
|
PROTAC Linkers
|
Cancer
|
|
TCO-PEG6-NHS ester is a PEG-based PROTAC linker can be used in the synthesis of PROTACs .
|
-
- HY-130770
-
|
|
PROTAC Linkers
|
Cancer
|
|
Ald-CH2-PEG3-CH2-Boc is a PEG- and Alkyl/ether-based PROTAC linker can be used in the synthesis of SGK3 kinase PROTAC degrader .
|
-
- HY-117519A
-
|
|
ADC Linker
PROTAC Linkers
|
Cancer
|
|
Amino-Tri-(carboxyethoxymethyl)-methane hydrochloride is a cleavable PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Amino-Tri-(carboxyethoxymethyl)-methan hydrochloride is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-117519
-
|
|
ADC Linker
PROTAC Linkers
|
Cancer
|
|
Amino-Tri-(carboxyethoxymethyl)-methane is a cleavable PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Amino-Tri-(carboxyethoxymethyl)-methan is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-22391
-
|
tert-Butyl 2,8-diaminooctanoate
|
PROTAC Linkers
|
Cancer
|
|
tert-Butyl (7-aminoheptyl)carbamate (tert-Butyl 2,8-diaminooctanoate) is a PROTAC linker. tert-Butyl (7-aminoheptyl)carbamate can be used to synthesis CPD-10 (HY-168660) .
|
-
- HY-139549
-
|
|
Ligands for E3 Ligase
Autophagy
Apoptosis
|
Cancer
|
|
Thalidomide-benzo hydrochloride is the Thalidomide-based cereblon ligand used in the recruitment of CRBN protein. Thalidomide-benzo can be connected to the ligand for protein by a linker to form PROTACs .
|
-
- HY-168223
-
|
|
PROTAC Linkers
|
Cancer
|
|
Boc-Piperazine-2-F-Ph-CHO (Compound 2) is a PROTAC linker, used for the synthesis of YD54 (HY-168221) .
|
-
- HY-168218
-
|
|
PROTAC Linkers
|
Cancer
|
|
Boc-Piperazine-piperidine-2-F-Ph-CHO is a PROTAC linker that can be used in the synthesis of YDR1 (HY-168215) .
|
-
- HY-130507
-
|
|
PROTAC Linkers
|
Cancer
|
|
Aminooxy-PEG5-azide is a PEG-based PROTAC linker can be used in the synthesis of PROTACs . Aminooxy-PEG5-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
|
-
- HY-126948
-
|
|
PROTAC Linkers
|
Cancer
|
|
Aminooxy-PEG1-azide is a PEG-based PROTAC linker can be used in the synthesis of PROTACs . Aminooxy-PEG1-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
|
-
- HY-126950
-
|
|
PROTAC Linkers
|
Cancer
|
|
Aminooxy-PEG4-azide is a PEG-based PROTAC linker can be used in the synthesis of PROTACs . Aminooxy-PEG4-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
|
-
- HY-169487
-
-
- HY-130820
-
|
|
PROTAC Linkers
|
Cancer
|
|
THP-PEG4-Pyrrolidine(N-Boc)-CH2OH is a PEG-based PROTAC linker can be used in the synthesis of PROTAC K-Ras Degrader-1 (HY-129523) .
|
-
- HY-130617
-
|
|
E3 Ligase Ligand-Linker Conjugates
|
Cancer
|
|
Pomalidomide-amido-C1-Br is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and a linker. Pomalidomide-amido-C1-Br can be used to design a B-Raf PROTAC degrader PROTAC B-Raf degrader 1 (HY-111758). PROTAC B-Raf degrader 1 has anti-cancer activity .
|
-
- HY-139227
-
-
- HY-130422
-
|
Tos-PEG4-Boc
|
PROTAC Linkers
|
Cancer
|
|
Tos-PEG4-t-butyl ester (Tos-PEG4-Boc) is a PROTAC linker, which refers to the PEG composition. Tos-PEG4-t-butyl ester (Tos-PEG4-Boc) can be used in the synthesis of a series of PROTACs, such as BI-3663 (HY-111546). BI-3663 is a highly selective PTK2/FAK PROTAC, with cereblon ligands to hijack E3 ligases for PTK2 degradation, and inhibits PTK2 with an IC50 of 18 nM .
|
-
- HY-137488
-
|
|
PROTACs
Raf
|
Cancer
|
|
PROTAC BRAF-V600E degrader-2 (compound 12) is a potent BRAF-V600E degrader with Kds of 14.4 nM and 9.5 nM for BRAF and BRAF-V600E, respectively. PROTAC BRAF-V600E degrader-2 selectively degraded the kinase domain of BRAF-V600E but not the wild-type BRAF. PROTAC BRAF-V600E degrader-2 inhibits melanoma cell growth .
|
-
- HY-168727
-
|
|
Kinesin
|
Cancer
|
|
KSP ligand 1 is a protein ligand that targets KSP (Kinesin), and it can be used to synthesize PROTAC KSP-IN-1 (HY-168725) for cancer research .
|
-
- HY-130640
-
-
- HY-130442
-
|
|
ADC Linker
PROTAC Linkers
|
Cancer
|
|
Mal-PEG2-acid is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Mal-PEG2-acid can be conjugated to Tubulysin (HY-128914) and its derivative cytotoxic molecule . Mal-PEG2-acid is also a PROTAC linker that can be used in the synthesis of PROTACs.
|
-
- HY-131184
-
|
|
PROTAC Linkers
|
Inflammation/Immunology
|
|
N-Boc-piperazine-C3-COOH is a PROTAC linker, which refers to the alkyl/ether composition. Boc-N-piperazine-C3-COOH can be used in the synthesis of PROTAC PD-1/PD-L1 degrader-1 (HY-131183) .
|
-
- HY-156566
-
|
|
Epigenetic Reader Domain
PROTACs
|
Cancer
|
|
PROTAC BRD4 Degrader-21 (Comp 74) is a PROTAC degrader of BRD4. PROTAC BRD4 Degrader-21 displays significant tumor growth inhibition in tumor -bearing xenograft models in mice and can be used for anticancer research .
|
-
- HY-130981
-
-
- HY-135345
-
|
|
PROTACs
FKBP
|
Cancer
|
|
PROTAC FKBP Degrader-3 is a PROTAC that comprises a FKBP ligand binding group, a linker and an von Hippel-Lindau binding group. PROTAC FKBP Degrader-3 is a potent FKBP degrader .
|
-
- HY-121507
-
|
|
PROTAC Linkers
|
Cancer
|
|
Hydroxy-PEG2-C2-sulfonic acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
|
-
- HY-130137
-
|
|
PROTAC Linkers
|
Cancer
|
|
m-PEG8-C10-phosphonic acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
|
-
- HY-169236
-
|
|
PROTAC Linkers
|
Cancer
|
|
COOH-C-PEG2-NHCO-C2-COOH is a PROTAC linker that is used to synthesize PCC16 chloride (HY-169232) .
|
-
- HY-W342590
-
|
|
Ligands for E3 Ligase
|
Cancer
|
|
CRBN ligand-9 (Compound 4d) is a CRBN ligand (Ki: 8.9 μM). CRBN ligand-9 can be used for synthesis of PROTACs .
|
-
- HY-168453
-
|
|
PROTACs
Epigenetic Reader Domain
|
Cancer
|
|
dBAZ2B is a BAZ2B PROTAC degrader, with a DC50 of 19 nM . (Pink: BAZ2A/B ligand (HY-168449); Black: linker (HY-168450); Blue: CRBN Ligand (HY-125905))
|
-
- HY-117690A
-
-
- HY-139185
-
|
|
PROTACs
Estrogen Receptor/ERR
|
Cancer
|
|
PROTAC ERRα Degrader-3 is a potent and selective ERRα degrader based on von Hippel-Lindau ligand. PROTAC ERRα Degrader-3 is capable of specifically degrading ERRα protein by >80% at a concentration of 30 nM. PROTAC ERRα Degrader-3 is inactive against ERRβ and ERRγ proteins .
|
-
- HY-117104
-
|
|
ADC Linker
PROTAC Linkers
|
Cancer
|
|
Hydroxy-PEG4-acid is a non-cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Hydroxy-PEG4-acid is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-151071
-
|
|
CDK
|
Cancer
|
|
TMX-3013 is a CDKs inhibitor capable of inhibiting the activity of CDK1, CDK2, CDK4, CDK5, and CDK6, with IC50 values of 0.9 nM, <0.5 nM, 24.5 nM, 0.5 nM, and 15.6 nM, respectively. TMX-3013 can be utilized for synthesizing PROTACs that feature a polyethylene glycol (PEG) linker arm and Thalidomide (HY-14658) as the CRBN-recruiting arm .
|
-
- HY-170353
-
|
|
Ligands for E3 Ligase
|
Cancer
|
|
E3 ligase Ligand 46 is a ligand for E3 ligase, used for the synthesis of PROTAC SMARCA2/4 degrader-36 (HY-170347) .
|
-
- HY-168197
-
|
|
PROTACs
|
Cancer
|
|
Thalidomide-F-piperidine-piperazine-Cbz Conjugate 110 is a conjugate of E3 ligase and linker for the synthesis of CDK12/13 PROTAC degrader (HY-168162) .
|
-
- HY-148896
-
-
- HY-140501
-
|
|
ADC Linker
PROTAC Linkers
|
Cancer
|
|
m-PEG11-acid is a non-cleavable 11 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . m-PEG11-acid is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-140500
-
|
|
ADC Linker
PROTAC Linkers
|
Cancer
|
|
m-PEG10-acid is a non-cleavable 10 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . m-PEG10-acid is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-108368
-
|
|
PROTAC Linkers
|
Cancer
|
|
Azido-PEG2-CH2COOH is a PEG-based PROTAC linker can be used in the synthesis of PROTACs . Azido-PEG2-CH2COOH is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
|
-
- HY-140164
-
|
|
PROTAC Linkers
|
Cancer
|
|
Azido-PEG2-C2-sulfonic acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . Azido-PEG2-C2-sulfonic acid is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
|
-
- HY-133484B
-
-
- HY-133702
-
|
|
PROTAC Linkers
|
Cancer
|
|
Aniline-piperazine-C3-NH-Boc (Compound Int-3) is a PROTAC linker, and can be used for synthesis of Pomalidomide-C3-adavosertib (HY-133618) and AZD1775 (HY-10993) (a Wee1 inhibitor) .
|
-
- HY-163238
-
|
|
Ligands for E3 Ligase
Autophagy
|
Cancer
|
|
Thalidomide-azetidine-CH-piperazineethanol is a conjugate of E3 ligase ligand and linker, consisting of Thalidomide (HY-14658) and the corresponding Linker. Thalidomide-azetidine-CH-piperazineethanol can serve as a Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.
|
-
- HY-163239
-
|
|
Ligands for E3 Ligase
Autophagy
|
Cancer
|
|
(R)-Thalidomide-piperazine-pyrrolidineethanol is a conjugate of E3 ligase ligand and linker, consisting of Thalidomide (HY-14658) and the corresponding Linker. (R)-Thalidomide-piperazine-pyrrolidineethanol can serve as Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.
|
-
- HY-141395
-
|
|
ADC Linker
PROTAC Linkers
|
Cancer
|
|
m-PEG4-Boc is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . m-PEG4-Boc is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-W890392
-
|
|
PROTAC Linkers
|
Cancer
|
|
(1r,4r)-tert-Butyl 4-(bromomethyl)cyclohexanecarboxylate is a PROTAC linker used in the synthesis of SMD-1087 (HY-170828) .
|
-
- HY-168970
-
-
- HY-155643
-
|
|
PROTACs
Glutaminase
|
Cancer
|
|
PROTAC TG2 degrader-1 (compound 11) is a von Hippel-Lindau (VHL)-based PROTAC targeting tissue transglutaminase (TG2) with a KD of 68.9 μM. PROTAC TG2 degrader-1 reduces TG2 in ovarian cancer cells in a proteasome-dependent manner .
|
-
- HY-140226
-
|
|
ADC Linker
PROTAC Linkers
|
Cancer
|
|
m-PEG10-amine is a non-cleavable 10 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . m-PEG10-amine is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-21577
-
|
|
ADC Linker
PROTAC Linkers
|
Cancer
|
|
Tris[[2-(tert-butoxycarbonyl)ethoxy]methyl]methylamine is a cleavable PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Amino-Tri-(t-butoxycarbonylethoxymethyl)-methane is also a PEG/Alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
![Tris[[2-(tert-butoxycarbonyl)ethoxy]methyl]methylamine](//file.medchemexpress.com/product_pic/hy-21577.gif)
- HY-126951
-
|
|
ADC Linker
PROTAC Linkers
|
Cancer
|
|
Aminooxy-PEG2-alcohol is a non-cleavable 2 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Aminooxy-PEG2-alcohol is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-141220
-
|
|
PROTAC Linkers
ADC Linker
|
Cancer
|
|
m-PEG12-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . m-PEG12-OH is also a non-cleavable 12 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) .
|
-
- HY-140227
-
|
|
PROTAC Linkers
ADC Linker
|
Cancer
|
|
m-PEG12-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . m-PEG12-amine is also a non-cleavable 12 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) .
|
-
- HY-124123
-
|
|
ADC Linker
PROTAC Linkers
|
Cancer
|
|
Aminooxy-PEG4-alcohol is a non-cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Aminooxy-PEG4-alcohol is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-168685
-
-
- HY-163985
-
|
|
PROTACs
FGFR
Apoptosis
|
Cancer
|
|
PROTAC FGFR2 degrader 1 (compound N5) is a PROTAC that effectively targets FGFR2 with DC50 of 6.46 nM, the FGFR2 IC50 is 0.08 nM. PROTAC FGFR2 degrader 1 has anti-proliferative activity and highly selective, induces G0/G1 arrest of KATOIII and SNU16 cell cycle and inhibits apoptosis by reducing the activation of p-ERK and p-PLCγ, the downstream proteins of FGFR2.
PROTAC FGFR2 degrader 1 inhibits gastric cancer cells remained above 50% at a concentration of 0.17 nM.
PROTAC FGFR2 degrader 1 potently inhibits the growth of SNU16 xenograft tumors in mouse model (Structure Note: Pink, FGFR2 activator: HY-18708; Blue, E3 ligase ligand: HY--10984; Black, linker: HY-163989; E3 ligase ligand + linker：HY-163986) .
|
-
- HY-163236
-
|
|
Ligands for E3 Ligase
Autophagy
|
Cancer
|
|
Thalidomide-piperidine-O-azetidine-acetic acid is a conjugate of E3 ligase ligand and linker, consisting of Thalidomide (HY-14658) and the corresponding Linker. Thalidomide-piperidine-O-azetidine-acetic acid can serve as a Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.
|
-
- HY-140809
-
|
|
PROTAC Linkers
|
Cancer
|
|
Azido-PEG4-(CH2)3OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . Azido-PEG4-(CH2)3OH is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
|
-
- HY-140590
-
|
|
PROTAC Linkers
|
Cancer
|
|
Azido-PEG3-S-PEG3-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . Azido-PEG3-S-PEG3-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
|
-
- HY-140828
-
|
13-Azido-2,5,8,11-tetraoxatridecane
|
PROTAC Linkers
|
Cancer
|
|
m-PEG4-azide (13-Azido-2,5,8,11-tetraoxatridecane) is a PEG-based PROTAC linker can be used in the synthesis of PROTACs . m-PEG4-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
|
-
- HY-168454
-
|
|
E3 Ligase Ligand-Linker Conjugates
|
Cancer
|
|
trans-VH032-Cyclopropane-F-C-cyclohexane-p-C-OTs incorporates an VHL ligand for the E3 ubiquitin ligase, and a PROTAC linker. VHL Ligand-Linker Conjugates 15 can be used to design PROTACs, such as dBAZ2B (HY-168453) .
|
-
- HY-133736
-
|
|
PROTAC-Linker Conjugates for PAC
ADC Cytotoxin
|
Cancer
|
|
PROTAC BRD4 Degrader-5-CO-PEG3-N3 (Compound 2) is a PROTAC-linker Conjugate for PAC, comprises the BRD4 degrader GNE-987 and PEG-based linker . PROTAC BRD4 Degrader-5-CO-PEG3-N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
|
-
- HY-148834
-
-
- HY-139436
-
-
- HY-168309
-
|
|
PROTAC Linkers
|
Others
|
|
7-(Piperidin-4-ylmethyl)-2,7-diazaspiro[3.5]nonane is the PROTAC linker of FHD-609 (HY-153367) .
|
-
![7-(Piperidin-4-ylmethyl)-2,7-diazaspiro[3.5]nonane](//file.medchemexpress.com/product_pic/hy-168309.gif)
- HY-23095
-
|
|
Ligands for E3 Ligase
Autophagy
Apoptosis
|
Cancer
|
|
Thalidomide-5-OH is the Thalidomide-based cereblon ligand used in the recruitment of CRBN protein. Thalidomide-5-OH can be connected to the ligand for protein by a linker to form PROTACs .
|
-
- HY-130708
-
UNC6852
2 Publications Verification
|
Histone Methyltransferase
PROTACs
|
Cancer
|
|
UNC6852 is a selective polycomb repressive complex 2 (PRC2) degrader based on PROTAC and contains an EED (embryonic ectoderm development) ligand and a von Hippel-Lindau ligand, with an IC50 of 247 nM for EED .
|
-
- HY-162745
-
|
|
PROTACs
|
Cancer
|
|
SMARCA2 degrader-20 is a PROTAC SMARCA2 degrader with a DC50 less than 100 nM in A549 cells .
|
-
- HY-120775
-
|
|
ADC Linker
PROTAC Linkers
|
Cancer
|
|
Boc-NH-PEG1-CH2CH2COOH is a cleavable (1 unit PEG) ADC linker and also a PEG- and Alkyl/ether-based PROTAC linker can be used in the synthesis of antibody-drug conjugates (ADCs) or PROTACs .
|
-
- HY-130819
-
|
|
PROTAC Linkers
|
Cancer
|
|
Tos-PEG4-THP is a PEG-based PROTAC linker can be used in the synthesis of PROTAC K-Ras Degrader-1 (HY-129523) .
|
-
- HY-130821
-
|
|
PROTAC Linkers
|
Cancer
|
|
THP-PEG4-Pyrrolidine(N-Me)-CH2OH is a PEG-based PROTAC linker can be used in the synthesis of PROTAC K-Ras Degrader-1 (HY-129523) .
|
-
- HY-169376
-
|
|
PROTAC Linkers
|
Cancer
|
|
Boc-piperazine-C13-OTs is a PROTAC linker. Boc-piperazine-C13-OTs can be used to synthesize NC-R17 (HY-155075) .
|
-
- HY-139540
-
|
|
Ligands for E3 Ligase
|
Cancer
|
|
Pomalidomide-6-OH is the Pomalidomide-based cereblon (CRBN) ligand used in the recruitment of CRBN protein. Pomalidomide-6-OH can be connected to the ligand for protein by a linker to form PROTAC .
|
-
- HY-141481
-
|
|
PROTACs
EGFR
PARP
|
Cancer
|
|
DP-C-4 is a Cereblon-based dual PROTAC for simultaneous degradation of EGFR and PARP .
|
-
- HY-126458
-
|
E3 ligase Ligand-Linker Conjugates 32
|
E3 Ligase Ligand-Linker Conjugates
Autophagy
Apoptosis
|
Cancer
|
|
Thalidomide-O-PEG2-propargyl (E3 ligase Ligand-Linker Conjugates 32) is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and 2-unit PEG linker used in PROTAC technology . Thalidomide-O-PEG2-propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
-
- HY-W013253
-
|
|
PROTAC Linkers
|
Cancer
|
|
Boc-11-aminoundecanoic acid is an Alkyl/ether-based PROTAC linker can be used in the synthesis of MS432 (HY-130602) .
|
-
- HY-161830
-
-
- HY-130228
-
|
|
PROTAC Linkers
|
Cancer
|
|
N3-PEG8-CH2COOH is a PEG-based PROTAC linker can be used in the synthesis of PROTACs . N3-PEG8-CH2COOH is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
|
-
- HY-130598
-
|
|
PROTAC Linkers
|
Cancer
|
|
N-(Azido-PEG3)-N-Boc-PEG4-acid is a PEG-based PROTAC linker with a terminal azide group and is used in the synthesis of PROTACs N-(Azido-PEG3)-N-Boc-PEG4-acid is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
|
-
- HY-168671
-
-
- HY-153821
-
|
|
Ras
PROTACs
|
Cancer
|
|
PROTAC KRAS G12C degrader-2 (compound 432) is a modulator of K-Ras protein hydrolysis. PROTAC KRAS G12C degrader-2 is a bifunctional compound, which contain on one end a cereblon inhibitor of apoptosis proteins (IAP) and on the other end a moiety which binds KRAS .
|
-
- HY-141218
-
|
Decaethylene glycol monomethyl ether
|
ADC Linker
PROTAC Linkers
|
Cancer
|
|
m-PEG10-alcohol (Decaethylene glycol monomethyl ether) is a non-cleavable 10 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . m-PEG10-alcohol is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-160017
-
|
|
E3 Ligase Ligand-Linker Conjugates
|
Cancer
|
|
Pomalidomide-5'-C8-acid (Compound 3d') is an E3 ligase ligand-linker conjugate containing a Pomalidomide (HY-10984) based cereblon (CRBN) ligand and a linker. Pomalidomide-5'-C8-acid can be used in the synthesis of PROTACs .
|
-
- HY-169151
-
|
|
PROTACs
Epigenetic Reader Domain
|
Cancer
|
|
PROTAC BRD4-DCAF1 degrader-1 (I-907) is a BRD4-DCAF1 PROTAC degrader, DC50 is 10~100 nM. (Pink: BRD4-DCAF1 ligand (HY-169152); Black: linker (HY-126976); Blue: E3 ligase ligand (HY-15846)) .
|
-
- HY-157164
-
|
|
PROTACs
Histone Methyltransferase
|
Cancer
|
|
PROTAC EZH2 Degrader-2 (compound E-3P-MDM2), an EZH2 inhibitor, is a PROTAC composed of Tazemetostat (EPZ6438) and an E3 ligase system ligand. PROTAC EZH2 Degrader-2 degrades EZH2 in SU-DHL-6 cells in a dose-dependent manner, inhibits the expression of H3K27me3, and simultaneously degrades EED and SUZ12 proteins without affecting their mRNA levels. PROTAC EZH2 Degrader-2 has anti-cancer and anti-proliferative activity .
|
-
- HY-146423
-
|
|
PROTACs
EGFR
Apoptosis
|
Cancer
|
|
PROTAC EGFR degrader 6, a PROTAC EGFR degrader, potently degrades EGFR Del19 in HCC827 cells with the DC50 of 45.2 nM. PROTAC EGFR degrader 6 significantly induces the apoptosis of HCC827 cells and arrest the cells in G1 phase .
|
-
- HY-150885
-
|
|
Ligands for Target Protein for PROTAC
Btk
|
Cancer
|
|
BTK ligand 1 (compound 1) is a ligand targeting Bruton’s tyrosine kinase (Btk). BTK ligand 1 can combine with E3 ligase ligand (Ligand for E3 Ligase) through PROTAC Linker to form PROTAC. PROTACs targeting Btk can be used in the study of chronic lymphocytic leukemia (CLL) and other BK cell malignancies .
|
-
- HY-155021
-
|
|
PROTACs
α-synuclein
|
Neurological Disease
|
|
PROTAC α-synuclein degrader 5 is a highly selective small-molecule degraders (PROTAC) of α-synuclein aggregates, with an DC50 of 7.51 μM and the highest degradation rate Dmax of 89%. PROTAC α-synuclein degrader 5 contains probe molecule sery308 and E3 ligase ligands. PROTAC α-synuclein degrader 5 can be used for neurological disease research .
|
-
- HY-149324
-
-
- HY-22340
-
|
|
PROTAC Linkers
|
Cancer
|
|
Azido-PEG4-alcohol is a PEG-based PROTAC linker can be used in the synthesis of PROTACs . Azido-PEG4-alcohol is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
|
-
- HY-W016735
-
|
|
PROTAC Linkers
|
Cancer
|
|
Azido-PEG3-alcohol is a PEG-based PROTAC linker can be used in the synthesis of PROTACs . Azido-PEG3-alcohol is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
|
-
- HY-133175
-
|
|
PROTAC Linkers
|
Cancer
|
|
Biotin-PEG7-azide is a PEG-based PROTAC linker can be used in the synthesis of PROTAC. Biotin-PEG7-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
|
-
- HY-126957
-
|
|
PROTAC Linkers
|
Cancer
|
|
Biotin-PEG2-azide is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Biotin-PEG2-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
|
-
- HY-130983
-
|
|
Btk
Ligands for Target Protein for PROTAC
|
Cancer
|
|
N-piperidine Ibrutinib hydrochloride (Compound 1) is a reversible Ibrutinib derivative. N-piperidine Ibrutinib hydrochloride is a potent BTK inhibitor with IC50s of 51.0 and 30.7 nM for WT BTK and C481S BTK, respectively . N-piperidine Ibrutinib hydrochloride can be used as a BTK ligand in the synthesis of a series of PROTACs, such as SJF620 (HY-133137). SJF620 is a potent PROTAC BTK degrader with a DC50 of 7.9 nM .
|
-
- HY-133174
-
|
|
PROTAC Linkers
|
Cancer
|
|
Biotin-PEG5-azide is a PEG-based PROTAC linker can be used in the synthesis of PROTAC. Biotin-PEG5-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
|
-
- HY-130407
-
|
|
PROTAC Linkers
|
Cancer
|
|
Lipoamido-PEG3-OH is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Lipoamido-PEG3-OH (compound TA-TEG-G2CN) can be used in the formation of a highly stable, dendronized gold nanoparticle (AuNP)-based drug delivery platform .
|
-
- HY-140307A
-
|
|
PROTAC Linkers
|
Others
|
|
Sulfo DBCO-PEG4-Maleimide TEA is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . Sulfo DBCO-PEG4-Maleimide (TEA) is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
|
-
- HY-140015A
-
|
|
PROTAC Linkers
|
Cancer
|
|
(S)-TCO-PEG3-acid is a click chemistry PEG linker with a terminal carboxylic acid(COOH) group. The terminal carboxylic acid is reactive with primary amine groups to form a stable amide bond. (S)-TCO-PEG3-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
|
-
- HY-151476
-
-
- HY-146422
-
|
|
PROTACs
EGFR
Apoptosis
|
Cancer
|
|
PROTAC EGFR degrader 5 (Compound 10), a PROTAC EGFR degrader, potently degrades EGFR Del19 in HCC827 cells with the DC50 of 34.8 nM. PROTAC EGFR degrader 5 significantly induces the apoptosis of HCC827 cells and arrest the cells in G1 phase .
|
-
- HY-168691
-
-
- HY-156568B
-
-
- HY-168314
-
-
- HY-161394
-
|
|
Others
|
Cancer
|
|
SPRT is a short peptide of RB transcriptional corepressor 1 (RB), serving as a fragment of RB-CO-PEG5-C2-CO-VH032 (HY-161393) for the synthesis of PROTAC .
|
-
- HY-161132
-
|
|
E3 Ligase Ligand-Linker Conjugates
|
Others
|
|
Lenalidomide 4'-alkyl-C5-azide is a functionalized cerebellar ligand for PROTAC development that contains an E3 ligand and an alkyl LC5 ligand with terminal azides that can be coupled to a target protein ligand .
|
-
- HY-47070
-
|
|
Ligands for E3 Ligase
|
Others
|
|
VH 101, acid is a functionalized von-Hippel-Lindau (VHL) protein ligand for PROTAC research and development. VH 101, acid contains an E3 ligase ligand plus an alkyl linker with terminal amine ready for conjugation to a target protein ligand .
|
-
- HY-120781
-
|
|
PROTAC Linkers
|
Cancer
|
|
Fluorescein-thiourea-PEG4-azide is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Fluorescein-thiourea-PEG4-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
|
-
- HY-168283
-
-
- HY-170988
-
-
- HY-168686
-
|
|
PROTAC Linkers
|
Cancer
|
|
6-Hydroxy-1-(4-(2-hydroxyethyl) piperazin-1-yl) hexan-1-one is the linker for PROTAC METTL3-14 degrader 1 (HY-162282) .
|
-
- HY-161468
-
-
- HY-137531
-
|
|
E3 Ligase Ligand-Linker Conjugates
|
Cancer
|
|
Pomalidomide-PEG1-C2-COOH is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 1-unit PEG linker used in PROTAC technology .
|
-
- HY-123324
-
|
5-Hydroxy pomalidomide; CC-17368
|
Ligands for E3 Ligase
|
Cancer
|
|
Pomalidomide-5-OH (5-hydroxy pomalidomide) is the Pomalidomide-based cereblon (CRBN) ligand used in the recruitment of CRBN protein. Pomalidomide-5-OH can be connected to the ligand for protein by a linker to form PROTAC .
|
-
- HY-131188
-
|
|
PROTACs
Bcl-2 Family
|
Cancer
|
|
PROTAC Bcl-xL degrader-1 is a PROTAC that comprises a Bcl-xL (Bcl-2 family member) ligand binding group, a linker and an IAP E3 ligases binding group. PROTAC Bcl-xL degrader-1 is a potent Bcl-xL degrader, and shows toxicity for human platelets and MyLa 1929 cells with IC50 values of 62 nM and 8.5 μM, respectively .
|
-
- HY-133191
-
|
|
PROTAC Linkers
|
Infection
Cancer
|
|
Bis-propargyl-PEG2 is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Bis-propargyl-PEG2 is used for the synthesis of demethylvancomycin dimers . Bis-propargyl-PEG2 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
-
- HY-139546
-
|
|
E3 Ligase Ligand-Linker Conjugates
Autophagy
Apoptosis
|
Cancer
|
|
Thalidomide-5-propargyne-NH2 hydrochloride is the Thalidomide-based cereblon ligand used in the recruitment of CRBN protein. Thalidomide-5-propargyne-NH2 hydrochloride can be connected to the ligand for protein by a linker to form PROTACs .
|
-
- HY-158430
-
-
- HY-170315
-
|
|
PROTAC Linkers
|
Cancer
|
|
Ethyne-C2-Pip-CO-Pip-Boc (Compound 21) is a PROTAC linker. Ethyne-C2-Pip-CO-Pip-Boc can be used to synthesize QA-68 (HY-150797) .
|
-
- HY-170986
-
-
- HY-139541
-
|
|
Ligands for E3 Ligase
|
Cancer
|
|
Pomalidomide-5-O-CH3 is the Pomalidomide-based cereblon (CRBN) ligand used in the recruitment of CRBN protein. Pomalidomide-5-O-CH3 can be connected to the ligand for protein by a linker to form PROTAC .
|
-
- HY-139542
-
|
|
Ligands for E3 Ligase
|
Cancer
|
|
Pomalidomide-6-O-CH3 is the Pomalidomide-based cereblon (CRBN) ligand used in the recruitment of CRBN protein. Pomalidomide-6-O-CH3 can be connected to the ligand for protein by a linker to form PROTAC .
|
-
- HY-133189
-
|
|
PROTAC Linkers
|
Endocrinology
|
|
Bis-propargyl-PEG9 is a PEG-based PROTAC linker used in the synthesis of PROTACs. Bis-propargyl-PEG9 can be used to synthesize the bivalent estrogen receptor ligands . Bis-propargyl-PEG9 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
-
- HY-168255
-
|
|
PROTACs
Epigenetic Reader Domain
|
Cancer
|
|
PROTAC BRM/BRG1 degrader-4 (example 047) is a potent BRM and BRG1 PROTAC degrader, with DC50 values of 0.21 nM and 3.4 nM in SW1573 cells, respectively (Pink: ligand for target protein (HY-168252); Black: linker (HY-28911); Blue: E3 ligase ligand (HY-168253)) .
|
-
- HY-140345A
-
|
|
PROTAC Linkers
|
Cancer
|
|
L-Homopropargylglycine hydrochloride is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs. L-homopropargylglycine hydrochloride is an amino acid analog of methionine containing an alkyne moiety that can undergo a classic click chemical reaction with azide containing Alexa Fluor .
|
-
- HY-140345
-
|
|
PROTAC Linkers
|
Cancer
|
|
L-Homopropargylglycine is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs. L-homopropargylglycine is an amino acid analog of methionine containing an alkyne moiety that can undergo a classic click chemical reaction with azide containing Alexa Fluor .
|
-
- HY-163167
-
|
|
E3 Ligase Ligand-Linker Conjugates
|
Others
|
|
VH 032 amide-alkylC5-amine is a functionalized von-Hippel-Lindau protein ligand (VHL) for PROTAC research and development; incorporates an E3 ligase ligand plus an alkyl linker with terminal amine ready for conjugation to a target protein ligand .
|
-
- HY-139543
-
-
- HY-150859
-
-
- HY-168308
-
|
|
Ligands for E3 Ligase
|
Cancer
|
|
(S)-Deoxy-thalidomide-Br is a ligand for E3 ligase, used for the synthesis of PROTAC FHD-609 (HY-153367) .
|
-
- HY-148880
-
|
|
Biochemical Assay Reagents
|
Others
|
|
VHLL-BCN can improve the efficiency of click chemistry reaction. VHLL-BCN can be used for the development of transcription factor (TF)-PROTAC .
|
-
- HY-148739
-
|
|
PROTACs
Epigenetic Reader Domain
|
Cancer
|
|
dBRD 9-A is a PROTAC which can selective degrade BRD9. dBRD 9-A improves the bromine domain binding profile and reduces the binding activity of the whole BET family .
|
-
- HY-133192
-
|
|
PROTAC Linkers
|
Infection
Cancer
|
|
Bis-propargyl-PEG3 is a PEG-based PROTAC linker used in the synthesis of PROTACs. Bis-propargyl-PEG3 is used in the synthesis of zinc-dipicolylamine (ZnDPA) complexes with antiplasmodial activity . Bis-propargyl-PEG3 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
-
- HY-168449
-
-
- HY-168299
-
-
- HY-168297
-
|
|
PROTAC Linkers
|
Cancer
|
|
Piperidine-C2-Pip-C-COOH is a linker for PROTAC BTK Degrader-5 (HY-155072), significantly improving metabolic stability, and can be used in cancer research .
|
-
- HY-168303
-
|
|
PROTAC Linkers
|
Cancer
|
|
(S)-4-(1-(Pyrrolidin-3-ylmethyl)piperidin-4-yl)aniline is a connector for PROTAC, which can be used to synthesize (R)-NX-2127 (HY-153220A) and is utilized in research within the field of malignant tumors .
|
-
- HY-135090
-
|
|
PROTAC Linkers
|
Cancer
|
|
Tos-PEG8-m is a derivative of silybin ethers, extracted from patent CN105037337A (compound III-d). Tos-PEG8-m is a PEG-based PROTAC linker can be used in the synthesis of Silymarin (HY-W043277) .
|
-
- HY-140455
-
|
|
PROTAC Linkers
|
Cancer
|
|
Azido-PEG10-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . Azido-PEG10-acid is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
|
-
- HY-161415
-
|
|
Ligands for E3 Ligase
|
Cancer
|
|
BCL-xL/BCL-2 ligand 1 (compound 72-1) is a BCL-xL and BCL-2 protein ligand. BCL-xL/BCL-2 ligand 1 can be connected to the E3 ligase by a linker to form PROTACs (HY-161410) .
|
-
- HY-155396
-
|
|
PROTACs
HDAC
|
Cancer
|
|
PRO-HD1 is a PROTAC HDAC6 degrader. PRO-HD1 degrades HDAC6 in A549 cells, and inhibits proliferation of Jurkat cells (IC50: 5.8 μM) .
|
-
- HY-108369
-
|
|
PROTAC Linkers
|
Cancer
|
|
Azido-PEG1-CH2CO2H is a PROTAC linker, which refers to the alkyl/ether composition. Azido-PEG1-CH2CO2H can be used in the synthesis of PROTAC BRD4 Degrader-1 . Azido-PEG1-CH2CO2H is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
|
-
- HY-170304
-
|
|
Ligands for E3 Ligase
|
Cancer
|
|
E3 ligase Ligand 44 is a ligand for E3 ligase, used for the synthesis of PROTAC AR Degrader-7 (HY-160221) .
|
-
- HY-49514
-
|
|
Ligands for E3 Ligase
|
Cancer
|
|
VHL Ligand intermediate-1 (intermediate 18a) is an intermediate in the synthesis of VHL E3 ubiquitin ligase ligand and can be used to synthesize PROTACs .
|
-
- HY-141161A
-
|
|
PROTAC Linkers
|
Cancer
|
|
(S)-TCO-PEG8-acid is a click chemistry PEG linker with a terminal carboxylic acid(COOH) group. The terminal carboxylic acid is reactive with primary amine groups to form a stable amide bond. (S)-TCO-PEG8-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. (S)-TCO-PEG8-acid is longer than (S)-TCO-PEG3-acid .
|
-
- HY-140802
-
|
|
PROTAC Linkers
|
Cancer
|
|
Azido-PEG11-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . Azido-PEG11-alcohol is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
|
-
- HY-117186
-
|
|
PROTAC Linkers
|
Metabolic Disease
|
|
Bis-propargyl-PEG6 is a PEG-based PROTAC linker used in the synthesis of PROTACs. Bis-propargyl-PEG6 can be used to synthesize the polymer linked multimers of guanosine-3', 5'-cyclic monophosphates . Bis-propargyl-PEG6 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
-
- HY-130143
-
|
|
PROTAC Linkers
|
Cancer
|
|
Biotin-PEG3-azide is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Biotin-PEG3-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
|
-
- HY-140217
-
|
|
PROTAC Linkers
|
Cancer
|
|
Azido-PEG10-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . Azido-PEG10-amine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
|
-
- HY-140801
-
|
|
PROTAC Linkers
|
Cancer
|
|
Azido-PEG10-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . Azido-PEG10-alcohol is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
|
-
- HY-140218
-
|
|
PROTAC Linkers
|
Cancer
|
|
Azido-PEG11-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . Azido-PEG11-amine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
|
-
- HY-133190
-
|
|
PROTAC Linkers
|
Metabolic Disease
|
|
Bis-propargyl-PEG7 is a PEG-based PROTAC linker used in the synthesis of PROTACs. Bis-propargyl-PEG7 can be used to synthesize the polymer linked multimers of guanosine-3', 5'-cyclic monophosphates . Bis-propargyl-PEG7 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
-
- HY-140759
-
|
|
PROTAC Linkers
|
Cancer
|
|
Azido-PEG10-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . Azido-PEG10-NHS ester is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
|
-
- HY-130197
-
|
|
PROTAC Linkers
|
Cancer
|
|
Lipoamido-PEG4-azide is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Lipoamido-PEG4-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
|
-
- HY-139545
-
-
- HY-136166
-
-
- HY-136156
-
|
|
E3 Ligase Ligand-Linker Conjugates
|
Cancer
|
|
Pomalidomide-PEG6-butyl iodide is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 6-unit PEG linker used in PROTAC technology .
|
-
- HY-49515
-
|
|
Ligands for E3 Ligase
|
Cancer
|
|
VHL Ligand intermediate-2 (compound 18c) is an intermediate for the synthesis of VHL E3 ubiquitin ligase ligand and can be used to synthesize PROTACs .
|
-
- HY-170817
-
-
- HY-118764
-
|
|
ADC Linker
PROTAC Linkers
|
Cancer
|
|
Propargyl-PEG2-acid is a non-cleavable 2 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Propargyl-PEG2-acid is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . Propargyl-PEG2-acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
-
- HY-130742
-
|
|
PROTAC Linkers
|
Cancer
|
|
Azido-PEG8-Boc is a PEG- and Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs . Azido-PEG8-Boc is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
|
-
- HY-130420
-
|
|
PROTAC Linkers
|
Cancer
|
|
Azido-PEG5-PFP ester is a PEG- and Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs . Azido-PEG5-PFP ester is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
|
-
- HY-W067061
-
|
|
ADC Linker
PROTAC Linkers
|
Cancer
|
|
Hydroxy-PEG2-(CH2)2-Boc is a uncleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Hydroxy-PEG2-(CH2)2-Boc is extracted from patent WO2004008101A2 (compound 196) . Hydroxy-PEG2-(CH2)2-Boc is also a PROTAC linker that can be used in the synthesis of PROTACs.
|
-
- HY-125905
-
|
VHL ligand 3; E3 ligase Ligand 19
|
Ligands for E3 Ligase
|
Cancer
|
|
VH032-cyclopropane-F is the VH032-based VHL ligand. VH032-cyclopropane-F can be connected to the ligand for protein (e.g., SMARCA BD ligand) by a linker to form PROTACs (e.g., PROTAC 1). PROTAC 1 is a partial degrader of SMARCA2 and SMARCA4 .
|
-
- HY-161538
-
-
- HY-134725
-
-
- HY-126456
-
|
VH032-propargyl; VHL ligand 7
|
Ligands for E3 Ligase
|
Cancer
|
|
(S,R,S)-AHPC-propargyl (VH032-propargyl) is a VHL ligand which is used in “click reaction” for PROTACs . (S,R,S)-AHPC-propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
-
- HY-44630
-
|
(S,R,S)-AHPC-CO-C6-COOH
|
E3 Ligase Ligand-Linker Conjugates
|
Cancer
|
|
VH 032 amide-alkylC6-acid ((S,R,S)-AHPC-CO-C6-COOH) is a VH032 analog that acts as a ligand for VHL, recruiting von Hippel-Lindau (VHL) protein. VH 032 amide-alkylC6-acid can be used in the synthesis of PROTACs .
|
-
- HY-151475
-
|
|
Ligands for Target Protein for PROTAC
|
Cancer
|
|
GID4 Ligand 1 (compound 88) is a cell-permeable and high-selective GID4 binder (IC50=5.4 μM; Kd=5.6 μM), binds to GID4 in cells (EC50=558 nM). GID4 Ligand 1 can be used for the synthesis of PROTACs .
|
-
- HY-133230
-
|
|
PROTAC Linkers
|
Cancer
|
|
Propargyl-PEG10-amine is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Propargyl-PEG10-amine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
-
- HY-130147
-
|
|
PROTAC Linkers
|
Cancer
|
|
Propargyl-PEG5-OH is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Propargyl-PEG5-OH is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
-
- HY-117045
-
|
|
PROTAC Linkers
|
Cancer
|
|
Propargyl-PEG12-OH is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Propargyl-PEG12-OH is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
-
- HY-114670
-
|
|
PROTAC Linkers
|
Cancer
|
|
Propargyl-PEG4-amine is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Propargyl-PEG4-amine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
-
- HY-130373
-
|
|
PROTAC Linkers
|
Cancer
|
|
Propargyl-PEG9-amine is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Propargyl-PEG9-amine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
-
- HY-113921
-
|
|
PROTAC Linkers
|
Cancer
|
|
m-PEG4-propargyl is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. m-PEG4-propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
-
- HY-140015
-
|
|
PROTAC Linkers
|
Cancer
|
|
TCO-PEG3-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs . TCO-PEG3-acid is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.
|
-
- HY-158325
-
|
|
PROTACs
FLT3
Apoptosis
|
Cancer
|
|
PROTAC FLT-3 degrader 4 is an orally active CRBN-based FLT3-PROTAC degrader that potently induces FLT3-ITD degradation through the ubiquitin-proteasome system. PROTAC FLT-3 degrader 4 shows highly selective to FLT3-ITD mutant acute myeloid leukemia (AML) cells. (Blue: CRBN ligand, Black: linker; Pink: FLT3 inhibitor) .
|
-
- HY-133049
-
|
|
PROTAC Linkers
|
Cancer
|
|
Propargyl-PEG3-phosphonic acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs . Propargyl-PEG3-phosphonic acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
-
- HY-130382
-
|
|
PROTAC Linkers
|
Cancer
|
|
Propargyl-PEG6-alcohol is a PEG-based PROTAC linker can be used in the synthesis of PROTACs . Propargyl-PEG6-alcohol is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
-
- HY-115414
-
|
|
PROTAC Linkers
|
Cancer
|
|
Bis-propargyl-PEG8 (compound 16e) is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Bis-propargyl-PEG8 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
-
- HY-130374
-
|
|
PROTAC Linkers
|
Cancer
|
|
Propargyl-PEG8-OH is a PEG-based PROTAC linker can be used in the synthesis of PROTACs . Propargyl-PEG8-OH is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
-
- HY-133229
-
|
|
PROTAC Linkers
|
Cancer
|
|
Propargyl-PEG4-alcohol is a PEG-based PROTAC linker can be used in the synthesis of PROTACs . Propargyl-PEG4-alcohol is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
-
- HY-130375
-
|
|
PROTAC Linkers
|
Cancer
|
|
Propargyl-PEG7-Boc is a PEG-based PROTAC linker can be used in the synthesis of PROTACs . Propargyl-PEG8-Boc is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
-
- HY-126977
-
|
|
PROTAC Linkers
|
Cancer
|
|
Propargyl-PEG9-OH is a PEG-based PROTAC linker can be used in the synthesis of PROTACs . Propargyl-PEG9-OH is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
-
- HY-117100
-
|
|
PROTAC Linkers
|
Cancer
|
|
Propargyl-PEG14-OH is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Propargyl-PEG14-OH is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups .
|
-
- HY-130378
-
|
|
PROTAC Linkers
|
Cancer
|
|
Propargyl-PEG7-alcohol is a PEG-based PROTAC linker can be used in the synthesis of PROTACs . Propargyl-PEG7-alcohol is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
-
- HY-130584
-
|
|
PROTAC Linkers
|
Cancer
|
|
Propargyl-PEG2-MS is a PEG-based PROTAC linker can be used in the synthesis of PROTACs . Propargyl-PEG2-MS is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
-
- HY-130380
-
|
|
PROTAC Linkers
|
Cancer
|
|
Propargyl-PEG7-Boc is a PEG-based PROTAC linker can be used in the synthesis of PROTACs . Propargyl-PEG7-Boc is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
-
- HY-130384
-
|
|
PROTAC Linkers
|
Cancer
|
|
Propargyl-PEG6-Boc is a PEG-based PROTAC linker can be used in the synthesis of PROTACs . Propargyl-PEG6-Boc is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
-
- HY-139309
-
|
|
Bcl-2 Family
PROTACs
|
Cancer
|
|
PROTAC Bcl-xL degrader-2 is a potent Bcl-xL (Bcl-2 family member) degrader based on von Hippel-Lindau ligand, with an IC50 of 0.6 nM.
|
-
- HY-162553
-
|
|
Ligands for E3 Ligase
|
Cancer
|
|
GNE7599 is a high-affinity and orally active von Hippel-Lindau (VHL) ligand with a Kd of 540 pM. GNE7599 can be connected to the ligand for protein by a linker to form PROTACs .
|
-
- HY-136186
-
|
VH032-C7-amine
|
E3 Ligase Ligand-Linker Conjugates
|
Cancer
|
|
(S,R,S)-AHPC-C7-amine (VH032-C7-amine) is a synthesized E3 ligase ligand-linker conjugate that incorporates the VH032 based VHL ligand and a linker used for estrogen-related receptor α (ERRα) PROTAC degrader .
|
-
- HY-155264
-
|
|
E3 Ligase Ligand-Linker Conjugates
|
Cancer
|
|
Pomalidomide-5-C8-NH2 hydrochloride is the Pomalidomide (HY-10984)-based cereblon (CRBN) ligand used in the recruitment of CRBN protein. Pomalidomide-5-C8-NH2 hydrochloride can be connected to the ligand for protein by a linker to form PROTAC .
|
-
- HY-136005
-
|
|
E3 Ligase Ligand-Linker Conjugates
|
Others
|
|
VH032-C7-COOH is a functionalized von-Hippel-Lindau (VHL) protein ligand for PROTAC research and development. VH032-C7-COOH contains an E3 ligase ligand and an alkyl linker with a terminal amine for conjugation of target protein ligands .
|
-
- HY-155260
-
|
|
E3 Ligase Ligand-Linker Conjugates
|
Cancer
|
|
Pomalidomide-5-C4-NH2 hydrochloride is the Pomalidomide (HY-10984)-based cereblon (CRBN) ligand used in the recruitment of CRBN protein. Pomalidomide-5-C4-NH2 hydrochloride can be connected to the ligand for protein by a linker to form PROTAC .
|
-
- HY-155262
-
|
|
E3 Ligase Ligand-Linker Conjugates
|
Cancer
|
|
Pomalidomide-5-C6-NH2 hydrochloride is the Pomalidomide (HY-10984)-based cereblon (CRBN) ligand used in the recruitment of CRBN protein. Pomalidomide-5-C6-NH2 hydrochloride can be connected to the ligand for protein by a linker to form PROTAC .
|
-
- HY-155259
-
|
|
E3 Ligase Ligand-Linker Conjugates
|
Cancer
|
|
Pomalidomide-5-C3-NH2 hydrochloride is the Pomalidomide (HY-10984)-based cereblon (CRBN) ligand used in the recruitment of CRBN protein. Pomalidomide-5-C3-NH2 hydrochloride can be connected to the ligand for protein by a linker to form PROTAC .
|
-
- HY-155261
-
|
|
E3 Ligase Ligand-Linker Conjugates
|
Cancer
|
|
Pomalidomide-5-C5-NH2 hydrochloride is the Pomalidomide (HY-10984)-based cereblon (CRBN) ligand used in the recruitment of CRBN protein. Pomalidomide-5-C5-NH2 hydrochloride can be connected to the ligand for protein by a linker to form PROTAC .
|
-
- HY-130146
-
|
|
PROTAC Linkers
|
Cancer
|
|
Propargyl-PEG3-phosphonic acid diethyl ester is a PEG-based PROTAC linker can be used in the synthesis of PROTACs . Propargyl-PEG3-phosphonic acid diethyl ester is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
-
- HY-125876
-
|
|
PROTACs
Bcl-2 Family
|
Cancer
|
|
PROTAC Bcl2 degrader-1 (Compound C5) is a PROTAC based on Cereblon ligand, which potently and selectively induces the degradation of Bcl-2 (IC50, 4.94 μM; DC50, 3.0 μM) and Mcl-1 (IC50, 11.81 μM) by introducing the E3 ligase cereblon (CRBN)-binding ligand pomalidomide to Mcl-1/Bcl-2 dual inhibitor Nap-1 (Blue: CRBN ligand, Black: linker；Pink: Mcl-1/Bcl-2 inhibitor, Nap-1).
|
-
- HY-170303
-
-
- HY-153673
-
|
|
IRAK
PROTACs
|
Cancer
|
|
PROTAC IRAK4 degrader-8 (Compound 2) is a PROTAC IRAK4 degrader (IC50: 15.5 nM). PROTAC IRAK4 degrader-8 degrades IRAK4 in THP-1 cells (DC50: 1.8 nM)。PROTAC IRAK4 degrader-8 also inhibits L-6 production in human whole blood and LPS-induced human PBMC cells, with IC50s of 246 nM and 2.2 nM respectively .
|
-
- HY-168056
-
|
|
Others
|
Others
|
|
KRAS ligand 5 is the target protein ligand for PROTAC K-Ras Degrader-3 (HY-168054). PROTAC K-Ras Degrader-3 can specifically degrade KRAS mutated proteins .
|
-
- HY-168288
-
-
- HY-W087383
-
|
|
Ligands for E3 Ligase
Autophagy
Apoptosis
|
Cancer
|
|
Thalidomide 5-fluoride is a thalidomide-based Cereblon ligand used to recruit Cereblon protein. Thalidomide 5-fluoride can be linked to target protein ligands (e.g. IRAK4) through a linker to form PROTAC molecules (e.g. PROTAC IRAK4 degrader-1). PROTAC IRAK4 degrader-1 caused <20%, >20-50%, and >50% IRAK4 protein degradation in OCI-LY-10 cells at concentrations of 0.01, 0.1, and 1 μM, respectively .
|
-
- HY-161576
-
-
- HY-148777
-
|
|
PROTACs
Androgen Receptor
|
Cancer
|
|
A031 is a highly effective PROTAC androgen receptor (AR) degrader with an IC50 value less than 0.25 μM for AR protein degradation. A031 has an inhibitory effect on tumor growth in zebrafish with human prostate cancer (VCaP) .
|
-
- HY-145818
-
|
|
HDAC
PROTACs
|
Cancer
|
|
JPS035 is a benzamide-based Von Hippel-Lindau (VHL) E3-ligase proteolysis targeting chimeras (PROTAC). JPS035 degrades class I histone deacetylase (HDAC). JPS035 is potent HDAC1/2 degrader correlated with greater total differentially expressed genes and enhanced apoptosis in HCT116 cells .
|
-
- HY-145816
-
|
|
HDAC
PROTACs
|
Cancer
|
|
JPS016 is a benzamide-based Von Hippel-Lindau (VHL) E3-ligase proteolysis targeting chimeras (PROTAC). JPS016 degrades class I histone deacetylase (HDAC). JPS016 is potent HDAC1/2 degrader correlated with greater total differentially expressed genes and enhanced apoptosis in HCT116 cells .
|
-
- HY-145819
-
|
|
HDAC
PROTACs
|
Cancer
|
|
JPS036 is a benzamide-based Von Hippel-Lindau (VHL) E3-ligase proteolysis targeting chimeras (PROTAC). JPS036 degrades class I histone deacetylase (HDAC). JPS036 is potent HDAC1/2 degrader correlated with greater total differentially expressed genes and enhanced apoptosis in HCT116 cells .
|
-
- HY-145816A
-
|
|
HDAC
PROTACs
|
Cancer
|
|
JPS016 is a benzamide-based Von Hippel-Lindau (VHL) E3-ligase proteolysis targeting chimeras (PROTAC). JPS016 degrades class I histone deacetylase (HDAC). JPS016 is potent HDAC1/2 degrader correlated with greater total differentially expressed genes and enhanced apoptosis in HCT116 cells .
|
-
- HY-145815
-
|
|
HDAC
PROTACs
|
Cancer
|
|
JPS014 is a benzamide-based Von Hippel-Lindau (VHL) E3-ligase proteolysis targeting chimeras (PROTAC). JPS014 degrades class I histone deacetylase (HDAC). JPS014 is potent HDAC1/2 degrader correlated with greater total differentially expressed genes and enhanced apoptosis in HCT116 cells .
|
-
- HY-148406
-
-
- HY-169009
-
|
|
Acetyl-CoA Carboxylase
|
Infection
|
|
(Rac)-Spirotetramat-enol (Compound 8) is a ligand of acetyl-CoA carboxylase that can be used to synthesize PROTAC ADC degrader (HY-169008) .
|
-
- HY-W797383
-
-
- HY-133137A
-
|
|
PROTACs
Btk
|
Cancer
|
|
SJF620 hydrochloride is a PROTAC connected by ligands for Cereblon and Btk with a DC50 of 7.9 nM. SJF620 contains a Lenalidomide analog for recruiting CRBN .
|
-
- HY-133137
-
|
|
PROTACs
Btk
|
Cancer
|
|
SJF620 is a PROTAC connected by ligands for Cereblon and Btk with a DC50 of 7.9 nM. SJF620 contains a Lenalidomide analog for recruiting CRBN .
|
-
- HY-137538
-
|
|
E3 Ligase Ligand-Linker Conjugates
|
Cancer
|
|
Pomalidomide-PEG3-azide is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 3-unit PEG linker used in PROTAC technology . Pomalidomide-PEG3-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
|
-
- HY-137537
-
|
|
E3 Ligase Ligand-Linker Conjugates
|
Cancer
|
|
Pomalidomide-PEG2-azide is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 2-unit PEG linker used in PROTAC technology . Pomalidomide-PEG2-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
|
-
- HY-168448
-
|
|
PROTACs
Epigenetic Reader Domain
|
Cancer
|
|
dBAZ2 is a first-in-class BAZ2A and BAZ2B PROTAC degrader with DC50 values of 180 nM and 250 nM for BAZ2A and BAZ2B, respectively. (Blue: E3 ligase ligand (VH 101, thiol (HY-47851); Black: linker (HY-168450); pink: target protein ligand (HY-168449)) .
|
-
- HY-136187
-
|
VH032-C5-NH2
|
E3 Ligase Ligand-Linker Conjugates
|
Cancer
|
|
(S,R,S)-AHPC-C5-NH2 (VH032-C5-NH2) is a synthesized E3 ligase ligand-linker conjugate that incorporates the VH032 based VHL ligand and a linker used for estrogen-related receptor α (ERRα) PROTAC degrader .
|
-
- HY-147192
-
|
|
E3 Ligase Ligand-Linker Conjugates
|
Cancer
|
|
(S,R,S)-AHPC-O-PEG1-propargyl (Compound 10b) is an E3 ligand for the synthesis of PROTAC . (S,R,S)-AHPC-O-PEG1-propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
-
- HY-163647
-
|
|
E3 Ligase Ligand-Linker Conjugates
|
Cancer
|
|
Lenalidomide-COCH-PEG2-azido is a synthesized E3 ligase ligand-linker conjugate that incorporates the Lenalidomide (HY-A0003) based cereblon ligand and a linker. Lenalidomide-COCH-PEG2-azido can be used in the synthesis of PROTAC AKR1C3 degrader-1 (HY-163609) .
|
-
- HY-148771
-
|
PROTAC AR-V7 degrader-2
|
PROTACs
Androgen Receptor
Apoptosis
|
Cancer
|
|
MTX-23 is an AR-based PROTAC. MTX-23 inhibits CaP cellular proliferation by degrading AR-V7 and AR-FL. MTX-23 induces apoptosis .
|
-
- HY-155685
-
|
|
PROTACs
VEGFR
Ephrin Receptor
Apoptosis
|
Cancer
|
|
SA-VA is an intracellular self-assembled PROTAC based on azide and alkyne. SA-VA is able to selectively degrade VEGFR-2 and EphB4 proteins in U87 cells. SA-VA can be converted to PROTAC in situ by click reaction with the help of endogenous copper in tumor tissues. SA-VA promotes apoptosis and blocks cells in S phase .
|
-
- HY-163920
-
|
|
PROTACs
HDAC
|
Cancer
|
|
Degrader-1 (compound Z16) is a potent and selective HDAC8 PROTAC degrader with an DC50 of 0.27 nM in A549 cells .
|
-
- HY-139334
-
-
- HY-115718A
-
|
|
PROTACs
Bcl-2 Family
|
Cancer
|
|
PZ703b TFA is a Bcl-xl PROTAC degradation agent that induces apoptosis and inhibits cancer cell proliferation for bladder cancer research .
|
-
- HY-150616
-
-
- HY-130312
-
|
|
PROTAC Linkers
|
Cancer
|
|
N-(Azido-PEG4)-N-Boc-PEG4-NHS ester is a PEG-based PROTAC linker with a terminal azide group. N-(Azido-PEG4)-N-Boc-PEG4-NHS ester is used in the synthesis of PROTACs N-(Azido-PEG4)-N-Boc-PEG4-NHS ester is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
|
-
- HY-138678B
-
-
- HY-43722
-
|
|
Ligands for E3 Ligase
|
Cancer
|
|
Lenalidomide-Br (Compound 41) is an analog of cereblon (CRBN) ligand Lenalidomide for E3 ubiquitin ligase, and is used in the recruitment of CRBN protein. Lenalidomide-Br can be connected to the ligand for protein by a linker to form PROTACs, such as the PROTAC STAT3 degrader SD-36 (HY-129602) .
|
-
- HY-126894
-
|
|
PROTAC Linkers
ADC Linker
|
Cancer
|
|
Bis- PEG9- acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Bis- PEG9- acid is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
|
-
- HY-130711A
-
|
VH032-C3-NH2 TFA
|
E3 Ligase Ligand-Linker Conjugates
|
Cancer
|
|
(S,R,S)-AHPC-C3-NH2 TFA (VH032-C3-NH2 TFA) is a synthesized E3 ligase ligand-linker conjugate that incorporates the VH032 based VHL ligand and a linker used in PROTAC technology. (S,R,S)-AHPC-C3-NH2 can be used in the synthesis of a series of PROTACs, such as UNC6852 (HY-130708). UNC6852 is an EED-targeted bivalent chemical degrader .
|
-
- HY-168274
-
|
|
PROTACs
Apoptosis
|
Cancer
|
|
PROTAC TRIB2 degrader-1 (Compound 5k) is an effective TRIB2 degrader that selectively induces TRIB2 degradation through the CRBN-dependent ubiquitin-proteasome pathway. PROTAC TRIB2 degrader-1 can inhibit cell proliferation and induce cell apoptosis, and can be used in cancer research. (Target protein ligand (Pink): HY-168275; linker (black): HY-168276; E3 Ligase Ligand-Linker Conjugates: HY-168277; E3 ligase (Blue): HY-W023573) .
|
-
- HY-130711
-
|
VH032-C3-NH2
|
E3 Ligase Ligand-Linker Conjugates
|
Cancer
|
|
(S,R,S)-AHPC-C3-NH2 (VH032-C3-NH2) is a synthesized E3 ligase ligand-linker conjugate that incorporates the VH032 based VHL ligand and a linker used in PROTAC technology. (S,R,S)-AHPC-C3-NH2 can be used in the synthesis of a series of PROTACs, such as UNC6852 (HY-130708). UNC6852 is an EED-targeted bivalent chemical degrader .
|
-
- HY-130563
-
|
|
PROTAC Linkers
|
Cancer
|
|
Propargyl-PEG3-CH2COOH is a PEG-based PROTAC linker can be used in the synthesis of PROTACs . Propargyl-PEG3-CH2COOH is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
-
- HY-114661
-
|
|
PROTAC Linkers
|
Cancer
|
|
m-PEG4-Tos is a derivative of silybin ethers, extracted from patent CN105037337A (compound III-b). m-PEG4-Tos is a PEG-based PROTAC linker can be used in the synthesis of Silymarin (HY-W043277) .
|
-
- HY-W042501
-
|
|
PROTAC Linkers
|
Cancer
|
|
m-PEG5-Tos is a derivative of silybin ethers, extracted from patent CN105037337A (compound III-c). m-PEG5-Tos is a PEG-based PROTAC linker can be used in the synthesis of Silymarin (HY-W043277) .
|
-
- HY-120217
-
VH032
3 Publications Verification
|
Ligands for E3 Ligase
|
Cancer
|
|
VH032 is a VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. VH032 is a VHL/HIF-1α interaction inhibitor with a KdPROTACs .
|
-
- HY-153959
-
|
|
E3 Ligase Ligand-Linker Conjugates
|
Cancer
|
|
Thalidomide-O-amido-C11-COOH (compound IMiD acid 1) is an E3 ligase ligand and linker CRBN (Cereblon) conjugate. Thalidomide-O-amido-C11-COOH can be used to synthesize PROTAC that target the degradation of DOT1L .
|
-
- HY-161177
-
|
|
PROTACs
Ras
|
Infection
|
|
PROTAC KRAS G12D degrades SARS-CoV-2, 3-curd trypsin-like protease (3CLPro). Protac KRAS G12D degrades SARS-CoV-2, 3-curd trypsin-like protease (3CLPRO). The PROTAC molecule is designed by partially coupling a GC-376-based dipeptidyl 3CLPro ligand with pomadomide via a piperazine-piperidine linker .
|
-
- HY-160555
-
-
- HY-150879
-
-
- HY-130737
-
|
|
E3 Ligase Ligand-Linker Conjugates
|
Cancer
|
|
Pomalidomide 4'-alkylC5-acid (Example 3) is an E3 ligase ligand-linker conjugate containing a Pomalidomide (HY-10984) based cereblon (CRBN) ligand and a linker. Pomalidomide 4'-alkylC5-acid can be used in the synthesis of PROTAC .
|
-
- HY-130389
-
|
|
PROTAC Linkers
|
Cancer
|
|
Propargyl-PEG4-O-C1-Boc is a PEG-based PROTAC linker can be used in the synthesis of PROTACs . Propargyl-PEG4-O-C1-Boc is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
-
- HY-130693
-
|
|
PROTAC Linkers
|
Cancer
|
|
Azido-PEG5-CH2CO2-PFP is a PEG- and Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs . Azido-PEG5-CH2CO2-PFP is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
|
-
- HY-131183
-
|
|
PROTACs
PD-1/PD-L1
|
Inflammation/Immunology
|
|
PROTAC PD-1/PD-L1 degrader-1, a PD-1/PD-L1 PROTAC based on Cereblon E3 ligand, inhibits PD-1/PD-L1 interaction with an IC50 of 39.2 nM. PROTAC PD-1/PD-L1 degrader-1 significantly restores the immunity repressed in a co-culture model of Hep3B/OS-8/hPD-L1 and CD3 T cells. PROTAC PD-1/PD-L1 degrader-1 moderately reduces the protein levels of PD-L1 in a lysosome-dependent manner .
|
-
- HY-148362
-
-
- HY-156366
-
|
|
PROTACs
|
Others
|
|
SNX7886 is a potent protac degrader of CDK8/19. SNX7886 degrades CDK 8 and CDK 19 with 90% and 80% degradation in 293 cells, respectively .
|
-
- HY-150400
-
-
- HY-168076
-
|
|
PROTAC-Linker Conjugates for PAC
|
Cancer
|
|
(S)-Deoxy-thalidomide-2,7-diazaspiro[3.5]nonane-CH2-Me-PIP-Boc consists of E3 ligase ligand and PROTAC linker of PROTAC K-Ras Degrader-3 (HY-168054). (S)-Deoxy-thalidomide-2,7-diazaspiro[3.5]nonane-CH2-Me-PIP-Boc is promising for research of cancers .
|
-
![(S)-Deoxy-thalidomide-2,7-diazaspiro[3.5]nonane-CH2-Me-PIP-Boc](//file.medchemexpress.com/product_pic/hy-168076.gif)
- HY-114872
-
-
- HY-132856
-
|
|
E3 Ligase Ligand-Linker Conjugates
|
Cancer
|
|
Lenalidomide-C5-amido-Boc is the Lenalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Lenalidomide-C5-amido-Boc can be connected to the ligand for protein by a linker to form PROTAC .
|
-
- HY-130390
-
|
|
PROTAC Linkers
|
Cancer
|
|
Propargyl-PEG4-O-C1-NHS ester (compound 8) is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Propargyl-PEG4-O-C1-NHS ester is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
-
- HY-129966
-
|
|
PROTACs
IRAK
|
Cancer
|
|
PROTAC IRAK4 degrader-1 is a Cereblon-based PROTAC interleukin-1 receptor-associated kinase 4 (IRAK4) degrader extracted from patent US20190192668A1 Compound I-210, makes <20%, >20-50%, and >50% IRAK4 degradation at 0.01, 0.1, and 1 μM in OCI-LY-10 cells, respectively .
|
-
- HY-400766
-
|
|
Drug Intermediate
|
Cancer
|
|
BWA-522 intermediate-2 is a BWA-522 intermediate. BWA-522 is an orally available small molecule protein-targeting chimera (PROTACs) with significant degradation effect on AR-FL and AR-V7 .
|
-
- HY-156814
-
|
|
Hedgehog
|
Cancer
|
|
HPP-9 is a Proteolysis-Targeting Chimeras （PROTACs） based on Hedgehog Pathway Inhibitor-1 (HPI-1), with the pIC50 of 6.71, that can degrade BET bromodomains. HPP-9 has antitumor activity [1[.
|
-
- HY-401056
-
|
|
Drug Intermediate
|
Cancer
|
|
BWA-522 intermediate-3 is a BWA-522 intermediate. BWA-522 is an orally available small molecule protein-targeting chimera (PROTACs) with significant degradation effect on AR-FL and AR-V7 .
|
-
- HY-140215
-
|
|
PROTAC Linkers
ADC Linker
|
Cancer
|
|
Azido-PEG6-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . Azido-PEG6-amine is also a non-cleavable 6 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Azido-PEG6-amine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
|
-
- HY-140004
-
|
|
PROTAC Linkers
ADC Linker
|
Cancer
|
|
Azide-PEG3-Tos is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . Azide-PEG3-Tos is also a non-cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Azide-PEG3-Tos is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
|
-
- HY-113931
-
|
|
PROTAC Linkers
ADC Linker
|
Cancer
|
|
Aminooxy-PEG2-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . Aminooxy-PEG2-azide is also a non-cleavable 2 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Aminooxy-PEG2-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
|
-
- HY-130211
-
|
|
ADC Linker
PROTAC Linkers
|
Cancer
|
|
Azido-PEG5-alcohol is a non-cleavable 5 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Azido-PEG5-alcohol is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . Azido-PEG5-alcohol is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
|
-
- HY-151110
-
|
|
PROTACs
CDK
|
Cancer
|
|
PROTAC CDK12/13 Degrader-1 (7f) is a highly selective cell cycle protein-dependent kinase CDK12/CDK13 dual degrader with the DC50 values of 2.2 nM and 2.1 nM, respectively. PROTAC CDK12/13 Degrader-1 has anti-proliferative activity and can be used in breast cancer research .
|
-
- HY-W877989
-
|
|
Ligands for E3 Ligase
|
Cancer
|
|
BWA-522 intermediate-1 is an intermediate in the synthesis of PROTAC BWA-522 (HY-149433) and serves as a ligand molecule for cereblon E3 ubiquitin ligase. BWA-522 is an orally active small molecule protein-targeting chimera (PROTAC) that has significant degradation effects on AR-FL and AR-V7 .
|
-
- HY-126893
-
|
|
PROTAC Linkers
ADC Linker
|
Cancer
|
|
Bis-PEG8-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Bis-PEG8-acid is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) .
|
-
- HY-146231
-
|
|
PROTACs
MAP4K
|
Inflammation/Immunology
Cancer
|
|
SS47, a PROTAC-based HPK1 degrader, exerts proteasome-mediated HPK1 degradation. The degradation of HPK1 via SS47 also significantly enhances the antitumor efficacy .
|
-
- HY-162307
-
|
|
PROTACs
Keap1-Nrf2
|
Cancer
|
|
Nrf2 degrader 1 (compound 1) is a PROTAC Nrf2 degrader with anticancer effects. Nrf2 degrader 1 inhibits cancer cells growth for A549 and LK-2 cells with IC50 values of 100 nM and 40 nM, respectively .
|
-
- HY-114872A
-
-
- HY-168635
-
|
|
PROTACs
Epigenetic Reader Domain
|
Cancer
|
|
SJ46420, a SJ46421 (HY-168634) pro-drug variant, is a potent and selective BRD3 PROTAC degrader. SJ46420 degrads BRD3 in a KLHDC2-dependent manner, thereby partially reducing the levels of BRD2 or BRD4 (Pink: ligand for target protein (HY-13030); Black: linker (HY-20797); Blue: E3 ligase ligand (HY-159973)) .
|
-
- HY-129941
-
|
VH032-C10-NH2
|
E3 Ligase Ligand-Linker Conjugates
|
Cancer
|
|
(S,R,S)-AHPC-C10-NH2 (VH032-C10-NH2) is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and a linker used for BET-Targeted PROTAC .
|
-
- HY-129941A
-
|
VH032-C10-NH2 dihydrochloride
|
E3 Ligase Ligand-Linker Conjugates
|
Cancer
|
|
(S,R,S)-AHPC-C10-NH2 dihydrochloride (VH032-C10-NH2 dihydrochloride) is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and a linker used for BET-Targeted PROTAC .
|
-
- HY-W580022
-
|
|
E3 Ligase Ligand-Linker Conjugates
|
Cancer
|
|
Pomalidomide-5'-PEG8-C2-COOH is an E3 Ligase Ligand-Linker Conjugates, consisting of Pomalidomide (HY-10984) and a linker. Pomalidomide-5'-PEG8-C2-COOH can be used for synthesis of PROTACs .
|
-
- HY-151110A
-
|
|
PROTACs
CDK
|
Cancer
|
|
PROTAC CDK12/13 Degrader-1 (7f) TFA is a highly selective cell cycle protein-dependent kinase CDK12/CDK13 dual degrader with the DC50 values of 2.2 nM and 2.1 nM, respectively. PROTAC CDK12/13 Degrader-1 TFA has anti-proliferative activity and can be used in breast cancer research .
|
-
- HY-140044
-
|
Propargyl-PEG2-NHMe
|
PROTAC Linkers
|
Cancer
|
|
Propargyl-PEG2-methylamine (Propargyl-PEG2-NHMe) is a PEG derivative containing a propargyl group and methylamine group. Propargyl-PEG2-methylamine is an PROTAC linker used in the synthesis of PROTACs. Propargyl-PEG2-methylamine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups .
|
-
- HY-155684
-
|
|
PROTACs
VEGFR
PDGFR
Ephrin Receptor
|
Cancer
|
|
SA-PA is an intracellular self-assembled PROTAC based on azide and alkyne. SA-PA is able to selectively degrade VEGFR-2, PDGFR-β and EphB4 proteins in U87 cells. SA-PA can be converted to PROTAC in situ by click reaction with the help of endogenous copper in tumor tissues .
|
-
- HY-126892
-
|
|
PROTAC Linkers
ADC Linker
|
Cancer
|
|
Bis-PEG7-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Bis-PEG6-propionic acid is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) .
|
-
- HY-126534
-
-
- HY-157767
-
|
|
PROTACs
ATM/ATR
|
Cancer
|
|
Abd110 (compound 42i) is a Lenalidomide-based PROTAC ATR kinase degrader. Abd110 selectively decreases ATR and phospho-ATR without affecting related kinases ATM and DNA-PKcs .
|
-
- HY-159779
-
-
- HY-103634
-
dFKBP-1
1 Publications Verification
|
PROTACs
FKBP
|
Cancer
|
|
dFKBP-1 is a potent and PROTAC-based FKBP12 degrader. dFKBP-1 incorporates the ligand SLF (HY-114872) of FKBP12, the Thalidomide based Cereblon ligand and a linker .
|
-
- HY-153536
-
|
|
PROTACs
Btk
|
Cancer
|
|
PROTAC BTK Degrader-3 is a potent BTK degrader with a DC50 value of 10.9 nM of BTK degradation in Mino cells. PROTAC BTK Degrader-3 has the potential for B-cell malignancies, including chronic lymphoid malignancies research .
|
-
- HY-126949
-
|
|
ADC Linker
PROTAC Linkers
|
Cancer
|
|
Aminooxy-PEG3-azide is a non-cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Aminooxy-C2-PEG3-azide is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . Aminooxy-PEG3-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
|
-
- HY-155008
-
|
|
PROTACs
Hexokinase
|
Cancer
|
|
PROTAC HK2 Degrader-1 is a PROTAC consisting of Lonidamine (HY-B0486) as a target protein Hexokinase 2 (HK2) inhibitor and Thalidomide (HY-14658) as a CRBN ligand-linked PROTAC. PROTAC HK2 Degrader-1 selectively inhibits the proliferation of breast cancer cells by forming a ternary complex through the ubiquitin-proteasome system to degrade Hexokinase 2 (HK2) protein leading to mitochondrial damage and cell death. PROTAC HK2 Degrader-1 effectively inhibits breast tumor growth and reduces the colonic side effects of cisplatin for breast cancer research .
|
-
- HY-169379
-
-
- HY-130408
-
|
|
ADC Linker
PROTAC Linkers
|
Cancer
|
|
m-PEG6-Amine is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. m-PEG6-Amine is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) .
|
-
- HY-W018174
-
|
|
ADC Linker
PROTAC Linkers
|
Cancer
|
|
m-PEG3-Amine is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. m-PEG3-Amine is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) .
|
-
- HY-130410
-
|
|
ADC Linker
PROTAC Linkers
|
Cancer
|
|
Bis-PEG6-NHS ester is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Bis-PEG6-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) .
|
-
- HY-147858
-
|
|
PROTACs
EGFR
Apoptosis
|
Cancer
|
|
PROTAC EGFR degrader 7 (compound 13b) is a potent and selective CRBN-recruiting PROTAC EGFR L858R/T790M degrader, with a DC50 of 13.2 nM. PROTAC EGFR degrader 7 inhibits NCI–H1975 cells proliferation, with an IC50 of 46.82 nM. PROTAC EGFR degrader 7 significantly induces apoptosis and G2/M phase arrest in NCI–H1975 cell. PROTAC EGFR degrader 7 shows antitumor activity, and can be used for non-small cell lung cancer (NSCLC) research . PROTAC EGFR degrader 7 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
-
- HY-130716
-
-
- HY-136257
-
|
|
PROTACs
|
Others
|
|
CMP98, a PROTAC, is unable to induce degradation of VHL. CMP98 can be used as a negative control compound for CM11 . CMP98 consists of two von Hippel-Lindau ligands on their active domain.
|
-
- HY-168700
-
-
- HY-147235
-
|
|
RIP kinase
PROTACs
|
Infection
|
|
RIPK2-IN-2 (example 25) is a RIP2 kinase PROTAC inhibitor. RIPK2-IN-2 can block RIP2-dependent proinflammatory signaling, regulated RIP2 kinase activity in auto inflammatory diseases .
|
-
- HY-140150
-
|
|
ADC Linker
PROTAC Linkers
|
Cancer
|
|
Azido-PEG3-Val-Cit-PAB-PNP is a cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Azido-PEG3-Val-Cit-PAB-PNP is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . Azido-PEG3-Val-Cit-PAB-PNP is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
|
-
- HY-140149
-
|
|
ADC Linker
PROTAC Linkers
|
Cancer
|
|
Azido-PEG4-Val-Cit-PAB-OH is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Azido-PEG4-Val-Cit-PAB-OH is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . Azido-PEG4-Val-Cit-PAB-OH is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
|
-
- HY-103597
-
|
Cereblon ligand 3; E3 ligase Ligand 3
|
Ligands for E3 Ligase
|
Others
|
|
Thalidomide-O-COOH (Cereblon ligand 3) is the Thalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Thalidomide-O-COOH (Cereblon ligand 3) can be connected to the ligand for protein by a linker to form PROTACs .
|
-
- HY-168221
-
|
|
PROTACs
|
Cancer
|
|
YD54 is a PROTAC based SMARCA2 degrader with a DC50 of 3.5 nM (Red: SMARCA2 degrader (HY-44012B), black: linker, Blue: E3 ligase ligand) .
|
-
- HY-130845
-
-
- HY-136010
-
|
|
RIP kinase
PROTACs
|
Inflammation/Immunology
|
|
RIP2 Kinase Inhibitor 4 is a potent and selective RIPK2 PROTAC. RIP2 Kinase Inhibitor 4 effectively degrades RIPK2 (pIC50 of 8) and inhibits the release of related TNF-α .
|
-
- HY-161828
-
|
|
PROTACs
CDK
|
Cancer
|
|
JWZ-5-13 is a potent CDK7 PROTAC degrader that significantly degrades CDK7 via the ubiquitin-proteasome system. JWZ-5-13 has antitumor activity. (Pink: Target protein ligand (HY-161830); Black: linker (HY-Y0925); Blue: E3 ligase ligand (HY-112078)) .
|
-
- HY-131866
-
|
VH 032 amide-alkylC2-acid
|
E3 Ligase Ligand-Linker Conjugates
|
Cancer
|
|
(S,R,S)-CO-C2-acid (VH 032 amide-alkylC2-acid) is a functionalized von-Hippel-Lindau (VHL) protein ligand that can be used in PROTAC research and development. (S,R,S)-CO-C2-acid contains an E3 ligand alkyl ligand for conjugation of target protein ligands .
|
-
- HY-130982
-
|
|
E3 Ligase Ligand-Linker Conjugates
|
Cancer
|
|
Lenalidomide-PEG3-iodine is a synthesized E3 ligase ligand-linker conjugate that incorporates the Lenalidomide based cereblon ligand and a 3-unit PEG linker. Lenalidomide-PEG3-iodine can be used in the synthesis of a series of PROTACs, such as SJF620 (HY-133137). SJF620 is a potent PROTAC BTK degrader with a DC50 of 7.9 nM .
|
-
- HY-139661
-
|
|
PROTAC Linkers
|
Cancer
|
|
Boc-bipiperidine-ethynylbenzoic acid is an Alkyl/ether-based PROTAC linker can be used in the synthesis of ARD-61 . Boc-bipiperidine-ethynylbenzoic acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
-
- HY-138965A
-
-
- HY-155150
-
|
|
LRRK2
PROTACs
|
Cancer
|
|
JH-XII-03-02 is a potent and selective LRRK2 PROTAC degrader. JH-XII-03-02 can be used for parkinson's Disease (PD) research .
|
-
- HY-131875
-
|
|
E3 Ligase Ligand-Linker Conjugates
|
Cancer
|
|
Pomalidomide 4'-alkylC3-acid is the E3 ligase ligand-linker conjugate used in the recruitment of CRBN protein. Pomalidomide 4'-alkylC3-acid can be used to synthesize PROTACs .
|
-
- HY-130845A
-
-
- HY-139339
-
|
|
E3 Ligase Ligand-Linker Conjugates
|
Cancer
|
|
Pomalidomide 4'-alkylC6-azide is the Pomalidomide (HY-123324)-based cereblon (CRBN) ligand used in the recruitment of CRBN protein. Pomalidomide 4'-alkylC6-azide can be connected to the ligand for protein by a linker to form PROTAC .
|
-
- HY-139333
-
|
|
E3 Ligase Ligand-Linker Conjugates
|
Cancer
|
|
Pomalidomide 4'-PEG5-azide is the Pomalidomide (HY-123324)-based cereblon (CRBN) ligand used in the recruitment of CRBN protein. Pomalidomide 4'-PEG5-azide can be connected to the ligand for protein by a linker to form PROTAC .
|
-
- HY-149295
-
|
|
PROTACs
Estrogen Receptor/ERR
Apoptosis
|
Cancer
|
|
PROTAC ERα Degrader-4 (Compound ZD12) is a highly potent and selectivePROTAC ERα degrader (Ki: 5.08 μM). PROTAC ERα Degrader-4 contains OBHSAs, linker and E3 ligase ligands. PROTAC ERα Degrader-4 shows excellent cell inhibitory and ERα degradation activity against Tamoxifen-sensitive and -resistant ER + breast cancer (BC) cells and ERα-mutated BC cells. PROTAC ERα Degrader-4 can induce apoptosis and can be used for cancer research.
|
-
- HY-130711C
-
|
VH032-C3-NH2 dihydrochloride
|
E3 Ligase Ligand-Linker Conjugates
|
Cancer
|
|
(S,R,S)-AHPC-C3-NH2 (dihydrochloride) is the dihydrochloride form of (S,R,S)-AHPC-C3-NH2 (HY-130711). (S,R,S)-AHPC-C3-NH2 (VH032-C3-NH2) is a synthesized E3 ligase ligand-linker conjugate that incorporates the VH032 based VHL ligand and a linker used in PROTAC technology. (S,R,S)-AHPC-C3-NH2 can be used in the synthesis of a series of PROTACs, such as UNC6852 (HY-130708). UNC6852 is an EED-targeted bivalent chemical degrader .
|
-
- HY-W259932
-
|
|
Ligands for E3 Ligase
|
Cancer
|
|
Lenalidomide 5'-piperazine is a functionalized cerebellar ligand for PROTAC development that binds an E3 ligand to terminal piperazine for subsequent chemical reactions to produce a protein deactivator with a rigid linker .
|
-
- HY-115718B
-
|
|
PROTACs
Apoptosis
Bcl-2 Family
|
Cancer
|
|
PZ703b hydrochloride is a Bcl-xl PROTAC degrader that induces apoptosis and inhibits cancer cell proliferation. PZ703b hydrochloride can be used for the research of bladder cancer research .
|
-
- HY-115718
-
PZ703b
3 Publications Verification
|
PROTACs
Bcl-2 Family
|
Cancer
|
|
PZ703b is a Bcl-xl PROTAC degrader that induces apoptosis and inhibits cancer cell proliferation. PZ703b can be used for the research of bladder cancer research .
|
-
- HY-169010
-
|
|
E3 Ligase Ligand-Linker Conjugates
|
Infection
|
|
Pomalidomide-CO-C5-Br (Compound 6b) is a conjugated compound of the E3 ligand Pomalidomide and linker. It can be used to synthesize highly effective PROTAC molecules targeting ADC (HY-169008) .
|
-
- HY-139341
-
|
|
E3 Ligase Ligand-Linker Conjugates
|
Cancer
|
|
Pomalidomide 4'-alkylC3-azide (compound 2a) is an E3 ligase ligand-linker conjugate containing a Pomalidomide (HY-10984) based cereblon (CRBN) ligand and a linker. Pomalidomide 4'-alkylC3-azide can be used in the synthesis of PROTAC .
|
-
- HY-139343
-
|
|
E3 Ligase Ligand-Linker Conjugates
|
Cancer
|
|
Pomalidomide 4'-alkylC2-azide (compound 2a) is an E3 ligase ligand-linker conjugate containing a Pomalidomide (HY-10984) based cereblon (CRBN) ligand and a linker. Pomalidomide 4'-alkylC2-azide can be used in the synthesis of PROTAC .
|
-
- HY-156395
-
|
|
E1/E2/E3 Enzyme
|
Cancer
|
|
MN551 is a potent inhibitor of cysteine-directed electrophilic covalent that plays important roles in the biology of SOCS2 and its CRL5 complex, and as E3 ligase handles in proteolysis targeting chimera (PROTACs) to induce targeted protein degradation .
|
-
- HY-137516A
-
|
|
PROTACs
Ras
|
Cancer
|
|
LC-2 epimer is a differential isomer of LC-2. LC-2 is a mutation-selective PROTAC depressant for KRAS and contains a ligand for the von Hippel Lindau E3 ligase linked to the KRAS inhibitor MRTX849 .
|
-
- HY-169359
-
|
|
Ligands for E3 Ligase
|
Others
|
|
4-Methylphenoxyacetic acid-Oxindole-CF3 is the E3 ligase ligand part of L134 (HY-169358). 4-Methylphenoxyacetic acid-Oxindole-CF3 can be utilized in PROTAC synthesis .
|
-
- HY-124625
-
-
- HY-162723
-
|
|
PROTACs
AP-1
|
Cancer
|
|
FOSL1 degrader 1 (4) is a T-5224-PROTAC, potently degrade FOSL1 (AP-1) to suppress cancer stemness gene expression in HNSCC. FOSL1 degrader 1 (4) effectively eliminate HNSCC cancer stem cells to inhibit tumor growth through degrading FOSL1. FOSL1 degrader 1 (4) displays around 30- to 100-fold increased potency over T-5224 (Pink: T-5224 (HY-12270); Black: Linker (HY-130200); Blue: Pomalidomide (HY-10984)) .
|
-
- HY-129776
-
|
|
Target Protein Ligand-Linker Conjugates
|
Cancer
|
|
K-Ras ligand-Linker Conjugate 2 incorporates a ligand for K-Ras, and a PROTAC linker, which recruit E3 ligases (such as VHL, CRBN, MDM2, and IAP). K-Ras ligand-Linker Conjugate 2 can be used in the synthesis of PROTAC K-Ras Degrader-1 (HY-129523), which is potent PROTAC K-Ras degrader that exhibits ≥70% degradation efficacy in SW1573 cells .
|
-
- HY-129775
-
|
|
Target Protein Ligand-Linker Conjugates
|
Cancer
|
|
K-Ras ligand-Linker Conjugate 1 incorporates a ligand for K-Ras, and a PROTAC linker, which recruit E3 ligases (such as VHL, CRBN, MDM2, and IAP). K-Ras ligand-Linker Conjugate 1 can be used in the synthesis of PROTAC K-Ras Degrader-1 (HY-129523), which is potent PROTAC K-Ras degrader that exhibits ≥70% degradation efficacy in SW1573 cells .
|
-
- HY-130813
-
-
- HY-161130
-
|
|
E3 Ligase Ligand-Linker Conjugates
|
Cancer
|
|
Lenalidomide 4'-PEG3-amine dihydrochloride is the Lenalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Lenalidomide 4'-PEG3-amine dihydrochloride can be connected to the ligand for protein by a linker to form PROTAC .
|
-
- HY-161134
-
|
|
E3 Ligase Ligand-Linker Conjugates
|
Cancer
|
|
Lenalidomide 4'-PEG2-azide is the Lenalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Lenalidomide 4'-PEG2-azide can be connected to the ligand for protein by a linker to form PROTAC .
|
-
- HY-161128
-
|
|
E3 Ligase Ligand-Linker Conjugates
|
Cancer
|
|
Lenalidomide 4'-PEG1-amine dihydrochloride is the Lenalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Lenalidomide 4'-PEG1-amine dihydrochloride can be connected to the ligand for protein by a linker to form PROTAC .
|
-
- HY-161129
-
|
|
E3 Ligase Ligand-Linker Conjugates
|
Cancer
|
|
Lenalidomide 4'-PEG2-amine dihydrochloride is the Lenalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Lenalidomide 4'-PEG2-amine dihydrochloride can be connected to the ligand for protein by a linker to form PROTAC .
|
-
- HY-169152
-
-
- HY-161450
-
|
|
PROTACs
Ras
|
Cancer
|
|
LHF418 is an effective SOS1 PROTAC degrader with a DC50 value of 209.4 nM in A549 cells. LHF418 can effectively inhibit RAS signaling and colony formation in KRAS-driven cancer cells. (Structural note: (Blue: Cereblon ligand (HY-A0003), Black: linker; Pink: SOS1 binder SOS1 Ligand intermediate-3 (HY-161452)) .
|
-
- HY-168230
-
-
- HY-130991
-
|
|
Target Protein Ligand-Linker Conjugates
|
Cancer
|
|
K-Ras ligand-Linker Conjugate 6 incorporates a ligand for K-Ras recruiting moiety, and a PROTAC linker, which recruit E3 ligases (such as VHL, CRBN, MDM2, and IAP). K-Ras ligand-Linker Conjugate 6 can be used in the synthesis of PROTAC K-Ras Degrader-1 (HY-129523), which is potent PROTAC K-Ras degrader that exhibits ≥70% degradation efficacy in SW1573 cells .
|
-
- HY-130194
-
|
|
ADC Linker
PROTAC Linkers
|
Cancer
|
|
Azido-PEG5-CH2CO2H is a cleavable 5 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Azido-PEG5-CH2CO2H is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . Azido-PEG5-CH2CO2H is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
|
-
- HY-129703B
-
|
Thalidomide-NH-PEG2-C2-NH2 hydrochloride
|
E3 Ligase Ligand-Linker Conjugates
Autophagy
Apoptosis
|
Cancer
|
|
Thalidomide-PEG2-C2-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and 2-unit PEG linker used in PROTAC technology .
|
-
- HY-136165
-
|
|
E3 Ligase Ligand-Linker Conjugates
|
Cancer
|
|
(S,R,S)-AHPC-PEG3-propionic acid is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 3-unit PEG linker used in PROTAC technology .
|
-
- HY-168192
-
|
|
E3 Ligase Ligand-Linker Conjugates
|
Cancer
|
|
Thalidomide-NH-C4-amide-C3-Br is a conjugate of the E3 ligase ligand Thalidomide with a linker and can be used in the synthesis of PROTAC TBL1X degrader-1 (HY-168190) .
|
-
- HY-139332
-
|
|
E3 Ligase Ligand-Linker Conjugates
|
Cancer
|
|
Pomalidomide 4'-PEG6-azide (compound 33e) is the E3 ligase ligand-linker conjugate used in the recruitment of CRBN protein. Pomalidomide 4'-alkylC3-acid can be used to synthesize PROTACs .
|
-
- HY-129703
-
-
- HY-126534A
-
|
LSN3106729 hydrochloride
|
Ligands for Target Protein for PROTAC
CDK
|
Cancer
|
|
Abemaciclib metabolite M18 (LSN3106729) hydrochloride, the metabolite of Abemaciclib (HY-16297A), is a CDK inhibitor with antitumor activity. Abemaciclib metabolite M18 hydrochloride and a CRBN ligand have been used to design PROTAC CDK4/6 degrader .
|
-
- HY-130988A
-
|
GDC-0068-NH2 dihydrochloride; RG7440-NH2 dihydrochloride
|
Ligands for Target Protein for PROTAC
|
Cancer
|
|
Ipatasertib-NH2 dihydrochloride is a ligand for target protein AKT for PROTAC (INY-03-041). INY-03-041 is composed of Ipatasertib-NH2, a ten-hydrocarbon linker, and a CRBN ligand Lenalidomide for E3 ubiquitin ligase .
|
-
- HY-160241
-
|
|
E3 Ligase Ligand-Linker Conjugates
|
Cancer
|
|
Lenalidomide-C5-acid is the Lenalidomide-based E3 ligase ligand-linker conjugate used in the recruitment of CRBN protein. Lenalidomide-C5-acid can be used to synthesize PROTACs .
|
-
- HY-168271
-
-
- HY-150905
-
|
|
EGFR
|
Cancer
|
|
EGFR ligand-2 (compound C4), a covalent EGFR ligand, is a EGFR mutant inhibitor with IC50s of 21 nM and 48 nM for EGFR L858R and EGFR L858R/T790M, respectively. EGFR ligand-2 can be used to synthesize PROTAC .
|
-
- HY-134823
-
|
|
MDM-2/p53
PROTACs
E1/E2/E3 Enzyme
|
Cancer
|
|
MD-222 is the first-in-class highly potent PROTAC degrader of MDM2. MD-222 consists of ligands for Cereblon and MDM2. MD-222 induces rapid degradation of the MDM2 protein and activation of wild-type p53 in cells. MD-222 has anticancer effects .
|
-
- HY-152261
-
|
|
PROTACs
|
Cancer
|
|
MS6105 is an LDH protein hydrolysis-targeted chimera (PROTAC) that effectively degrades LDHA and LDHB in a time- and ubiquitin-proteasome system-dependent manner and has anticancer activity . MS6105 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
-
- HY-147525
-
|
|
PROTACs
Histone Methyltransferase
|
Cancer
|
|
PROTAC EZH2 Degrader-1 (Compound 150d), a potent PROTAC EZH2 Degrader, exerts inhibitory effect on EZH2 methyltransferase activity with the IC50 of 2.7 nM. EZH2 plays an important role in many tumorigenesis and development processes .
|
-
- HY-129703A
-
-
- HY-157566
-
|
|
Ligands for E3 Ligase
|
Cancer
|
|
Lenalidomide 5'-piperazine-4-methylpiperidine hydrochloride is a functionalized cerebellar ligand for PROTAC development, combining E3 ligand and terminal piperidine for subsequent chemical reactions. A protein degradant with a rigid connector is generated .
|
-
- HY-169959
-
-
- HY-128716A
-
|
Cereblon Ligand-Linker Conjugates 5 TFA; E3 ligase Ligand-Linker Conjugates 30 TFA
|
E3 Ligase Ligand-Linker Conjugates
|
Cancer
|
|
Pomalidomide-PEG3-C2-NH2 TFA (Cereblon Ligand-Linker Conjugates 5 (TFA)) is a synthetic E3 ligase ligand-linker conjugate comprising a Pomalidomide (HY-10984)-based cereblon ligand and a 3-unit PEG linker. Pomalidomide-PEG3-C2-NH2 TFA can be used for the synthesis of PROTACs .
|
-
- HY-153414
-
|
|
Epigenetic Reader Domain
PROTACs
|
Cancer
|
|
GXF-111, a PROTAC molecule, can promote selective degradation of cellular BRD3 and BRD4-L. GXF-111 has binding affinities for BRD3 BD1 and BRD3 BD2 with Ki values of 11.97 nM and 2.35 nM, respectively. GXF-111 can be used for the research of cancer .
|
-
- HY-132998
-
|
|
PROTACs
|
Others
|
|
HDAC6 degrader-1 is a PROTAC that comprises a selective HDAC6 inhibitor Nexturastat A (Nex A) as the HDAC6 binder, a linker and a ligand for recruiting E3 ligase. HDAC6 degrader-1 induces significant degradation of HDAC6, exhibits excellent selectivity against other HDACs, and demonstrates efficient inhibition of cell proliferation .
|
-
- HY-146324
-
|
|
PROTACs
CaMK
Apoptosis
|
Cancer
|
|
PROTAC eEF2K degrader-1 (Compound 11l) is an eEF2K-Targeting PROTAC small molecule that induces apoptosis in MDA-MB-231 cells. PROTAC eEF2K degrader-1 mediates eEF2K degradation .
|
-
- HY-141881
-
|
|
PROTACs
Apoptosis
SF3B1
|
Cancer
|
|
PROTAC-O4I2 is a PROTAC targets splicing factor 3B1 (SF3B1). PROTAC-O4I2 induces FLAG-SF3B1 degradation with an IC50 value of 0.244 μM in K562 cells. PROTAC-O4I2 also induces cellular apoptosis in K562 WT cells .
|
-
- HY-168695
-
-
- HY-157491
-
-
- HY-141798
-
|
|
Ligands for Target Protein for PROTAC
|
Cancer
|
|
OICR-9429-N-C2-NH2 is a ligand for Wd40 repeat domain protein 5 (WDR5) extracted from patent WO2019246570A1, intermediate 2. OICR-9429-N-C2-NH2 can be used in the synthesis of PROTACs .
|
-
- HY-136187A
-
|
VH032-C5-NH2 dihydrochloride
|
E3 Ligase Ligand-Linker Conjugates
|
Cancer
|
|
(S,R,S)-AHPC-C5-NH2 (VH032-C5-NH2) dihydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the VH032 based VHL ligand and a linker used for estrogen-related receptor α (ERRα) PROTAC degrader .
|
-
- HY-138551A
-
|
|
E3 Ligase Ligand-Linker Conjugates
|
Cancer
|
|
(S,R,S)-AHPC-3-methylbutanyl acetate-methanesulfonothioate-Me-C10-NH2 TFA is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC ligand, it can be used in PROTAC technology .
|
-
- HY-168316
-
-
- HY-163815
-
|
|
PROTACs
CDK
|
Others
|
|
CDK2 degrader 2 is a PROTAC class CDK2 degrader. The CDK2 binding moiety (CBM) binds to the CDK2 protein and subsequently undergoes ubiquitination, leading to the degradation of CDK2 through the ubiquitin proteasome pathway (UPP). CDK2 degrader 2 can cause degradation of CDK2 in MKN1 cells, with a DC50 value less than 100 nM and an average Dmax value greater than 75%. (Red: CBM; Blue: DIM; Black: linker)
|
-
- HY-139156
-
|
|
PROTACs
PARP
|
Cancer
|
|
SK-575 is a highly potent and specific proteolysis-targeting chimera (PROTAC) degrader of PARP1, with an IC50 of 2.30 nM. SK-575 potently inhibits the growth of cancer cells bearing BRCA1/2 mutations .
|
-
- HY-133699
-
|
|
E3 Ligase Ligand-Linker Conjugates
|
Cancer
|
|
Pomalidomide-PEG4-COOH is a E3 ligase ligand-linker conjugate. Pomalidomide-PEG4-COOH contains the Pomalidomide based cereblon ligand and 4-unit PEG linker used in PROTAC technology (extracted from patent WO2017184995A1) .
|
-
- HY-130474
-
|
|
ADC Linker
PROTAC Linkers
|
Cancer
|
|
Azido-PEG6-NHS ester is a cleavable 6 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Azido-PEG6-NHS ester is also a PEG- and Alkyl/ether based PROTAC linker that can be used in the synthesis of PROTACs . Azido-PEG6-NHS ester is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
|
-
- HY-130184
-
|
|
ADC Linker
PROTAC Linkers
|
Cancer
|
|
Azido-PEG8-NHS ester is a cleavable 8 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Azido-PEG8-NHS ester is also a PEG- and Alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs . Azido-PEG8-NHS ester is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
|
-
- HY-130537
-
|
|
PROTAC Linkers
ADC Linker
|
Cancer
|
|
Azido-PEG6-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . Azido-PEG6-alcohol is also a non-cleavable 6 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Azido-PEG6-alcohol is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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-
- HY-133044
-
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PROTAC Linkers
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Cancer
|
|
Boc-Pip-alkyne-Ph-COOH is a PROTAC linker, which refers to the alkyl/ether composition. Boc-Pip-alkyne-Ph-COOH can be used in the synthesis of a series of PROTACs, such as ARD-266 (HY-133020). ARD-266 effectively induces degradation of androgen receptor (AR) protein in AR-positive LNCaP, VCaP, and 22Rv1 prostate cancer cell lines with DC50 values of 0.2-1 nM . Boc-Pip-alkyne-Ph-COOH is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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-
- HY-168298
-
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E3 Ligase Ligand-Linker Conjugates
|
Cancer
|
|
Lenalidomide-6-F-piperidine-C2-Pip-C-COOH is a linker and E3 ligase ligand for PROTAC BTK Degrader-5 (HY-155072) and can be used in malignant lymphoma research .
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-
- HY-133799
-
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E3 Ligase Ligand-Linker Conjugates
|
Cancer
|
|
Pomalidomide-C7-COOH is a synthesized E3 ligase cereblon ligand-linker conjugate. Pomalidomide-C7-COOH is an intermediate for the synthesis of PROTAC BCL-XL degraders .
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-
- HY-41547
-
|
Cereblon ligand 4; E3 ligase Ligand 4
|
Ligands for E3 Ligase
Autophagy
Apoptosis
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Cancer
|
|
Thalidomide 4-fluoride (Cereblon ligand 4) is the Thalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Thalidomide 4-fluoride (Cereblon ligand 4) can be connected to the ligand for IRAK4 protein by a linker to form PROTAC IRAK4 degrader-1 (HY-129966) .
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-
- HY-153803
-
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PROTACs
Molecular Glues
Btk
|
Cancer
|
|
GBD-9 is a double-mechanism degrader that efficiently degrades BTK and GSPT1 by recruiting the E3 ligase cereblon (CRBN). GBD-9 acts both as a PROTAC molecule to induce the degradation of BTK and as a molecular glue to degrade GSPT1. GBD-9 effectively inhibits cancer cell growth .
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-
- HY-135045
-
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VH032-C4-COOH
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E3 Ligase Ligand-Linker Conjugates
|
Cancer
|
|
(S,R,S)-AHPC-C4-COOH (VH032-C4-COOH) (linker 45) is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and a linker used for EED-targeted PROTAC .
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-
- HY-145479
-
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|
PROTACs
Androgen Receptor
|
Cancer
|
|
PROTAC AR-V7 degrader-1 (Compound 6) is a potent, orally bioavailable and selective AR-V7 degrader with the DC50 of 0.32 µM by recruiting VHL E3 ligase to Androgen receptor (AR) DNA binding domain (DBD) binder. PROTAC AR-V7 degrader-1 exhibits activity against 22Rv1 cell-line expressing AR-V7 with the EC50 of 0.88 µM .
|
-
- HY-169327
-
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PROTACs
MDM-2/p53
|
Cancer
|
|
MD-265 is a PROTAC degrader that can break down MDM2, leading to activation of p53 in cancer cells carrying wild-type p53. MD-265 achieves complete tumor regression and improves long-term survival of mice with leukemia. (Pink: MI-1063 (HY-133754); Black: linker; Blue: Lenalidomide (HY-A0003) .
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-
- HY-168612
-
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E3 Ligase Ligand-Linker Conjugates
|
Cancer
|
|
E3 Ligase Ligand-linker Conjugate 125 is an E3 ligase ligand-linker conjugate. E3 Ligase Ligand-linker Conjugate 125 can be used to synthesize PROTAC IRAK4 degrader-12 (HY-168586) .
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-
- HY-141680
-
CPS2
1 Publications Verification
|
PROTACs
CDK
|
Cancer
|
|
CPS2 is a first-in-class, highly potent, selective and irreversible PROTAC CDK2 degrader (IC50= 24 nM). CPS2 can be used for the research of acute myeloid leukemia .
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-
- HY-163209
-
|
(S,R,S)-AHPC-PEG6-NH2 hydrochloride
|
E3 Ligase Ligand-Linker Conjugates
|
Cancer
|
|
VH 032 amide-PEG6-amine hydrochloride (Step 4) is a functionalized von-Hippel-Lindau protein-ligand (VHL) for PROTAC development, consisting of an E3 ligand and a PEG6 ligand. Terminal amines can be coupled to target protein ligands .
|
-
- HY-136688
-
|
|
PROTACs
|
Cancer
|
|
MI-389 is a PROTAC translation termination factor GSPT1 degrader. MI-389 disrupts a target that is a shared dependency in different AML and ALL cell lines, and that MI-389 action is dependent on the CRL4 CRBN E3 ligase .
|
-
- HY-159017
-
|
|
E3 Ligase Ligand-Linker Conjugates
|
Cancer
|
|
EM-12-Alkyne-C6-OMs is a conjugate of E3 ligase ligand and linker, consisting of 2-(2,6-Dioxopiperidin-3-yl)phthalimidine (EM-12) (HY-138793) and the corresponding Linker (HY-159018). EM-12-Alkyne-C6-OMs can be used to synthesize PROTACs .
|
-
- HY-148273
-
|
KRAS G12D inhibitor 17
|
PROTACs
Ras
|
Cancer
|
|
Setidegrasib (KRAS G12D inhibitor 17, Example 8) is a PROTAC KRAS degrader (DC50: 37 nM). Setidegrasib induces the degradation of G12D-mutation KRAS protein. Setidegrasib has antitumor effect. (Blue: E3 ligase ligand (HY-168699); Black: linker (HY-168698); Pink: G12D ligand (HY-168700)) .
|
-
- HY-151719
-
|
2-Azidoacetic acid
|
ADC Linker
|
Others
|
|
Azidoacetic Acid (2-Azidoacetic acid) (compound 92-1) is a click chemistry reagent containing an azide group. Azidoacetic Acid can be used as a small molecule tool for the synthesis of PROTAC . It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.
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-
- HY-130612
-
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|
Epigenetic Reader Domain
PROTACs
|
Cancer
|
|
PROTAC BRD2/BRD4 degrader-1 (compound 15) is a potent and selective BET protein BRD4 and BRD2 degrader, connected by ligands for Cereblon and BET. PROTAC BRD2/BRD4 degrader-1 rapidly induces reversible, long-lasting, and unexpectedly selective removal of BRD4 and BRD2 over BRD3. It effectively inhibits solid tumors with low cytotoxic effect. PROTAC BRD2/BRD4 degrader-1 is composed of the BET inhibitor, a linker, and the ligand thalidomide for cereblon (CRBN)/cullin 4A .
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-
- HY-168254
-
|
|
E3 Ligase Ligand-Linker Conjugates
|
Cancer
|
|
E3 Ligase Ligand-linker Conjugate 127 is an E3 ligase ligand-linker conjugate. E3 Ligase Ligand-linker Conjugate 127 can be used to synthesize PROTAC BRM/BRG1 degrader-3 (HY-168251) .
|
-
- HY-47709
-
-
- HY-W998345
-
|
|
PROTACs
PDK-1
Akt
|
Cancer
|
SMART1 is a highly specific and CRBN-dependent PROTAC that can effectively degrade Smurf1. SMART1 can block the PDK1-Akt signaling pathway in KRAS mutant colorectal cancer. SMART1 can inhibit tumor growth in KRAS mutant colorectal cancer (CRC) xenograft models.(Blue: CRBN ligand; Black: linker; Pink: Smurf1 ligand (Smurf1-L)) .
|
-
- HY-168687
-
|
|
E3 Ligase Ligand-Linker Conjugates
|
Cancer
|
|
E3 Ligase Ligand-linker Conjugate 137 is the linker and E3 ligase ligand for the PROTAC METTL3-14 degrader 1 (HY-162282), which can be used for research on acute myeloid leukemia .
|
-
- HY-170326
-
|
|
Ligands for Target Protein for PROTAC
HSP
|
Cancer
|
|
Hsp90-in-35 (Compound 379) is an inhibitor of Hsp90. The IC50 of HSP90-IN-35 for Her2 is between 0.05 and 0.5 μM. HSP90-IN-35 has antitumor activity. HSP90-IN-35 can be used to synthesize PROTAC (HY-153881) .
|
-
- HY-168678
-
|
|
PROTACs
Ras
|
Cancer
|
|
pan-KRAS degrader 5 (compound 102) is a potent cereblon-based KRAS PROTAC degrader, with a DC50 of <100 nM. pan-KRAS degrader 5 shows anticancer effects. (Pink: ligand for target protein (HY-168679); Black: linker (HY-168670); Blue: E3 ligase ligand (HY-W580113)) .
|
-
- HY-168669
-
|
|
PROTACs
Ras
|
Cancer
|
|
pan-KRAS degrader 4 (compound 69) is a potent cereblon-based KRAS PROTAC degrader, with a DC50 of <100 nM. pan-KRAS degrader 4 shows anticancer effects. (Pink: ligand for target protein (HY-168671); Black: linker (HY-168670); Blue: E3 ligase ligand (HY-W733895)) .
|
-
- HY-169969
-
-
- HY-130979
-
-
- HY-160077
-
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E3 Ligase Ligand-Linker Conjugates
|
Cancer
|
|
Pomalidomide-CO-C5-azide (Compound PA) is a ligand for E3 ligase bearing a bioorthogonal group azide. Pomalidomide-CO-C5-azide can be used to synthesize PROTACs with anticancer activity .
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-
- HY-42618
-
|
|
ADC Linker
PROTAC Linkers
|
Cancer
|
|
Azido-PEG4-CH2-Boc is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Azido-PEG4-CH2-Boc is also a PEG- and Alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs . Azido-PEG4-CH2-Boc is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
|
-
- HY-168593
-
|
|
β-catenin
PROTACs
Histone Demethylase
|
Cancer
|
|
Wnt/β-catenin-IN-5 (Compound 4) is an inhibitor of the Wnt/β-catenin signaling pathway. Wnt/β-catenin-IN-5 eliminates colorectal cancer stem cells and inhibits tumor growth by suppressing the Wnt signaling pathway. PROTACs Wnt/β-catenin-IN-5, which is also a PROTAC based on IOX1, effectively induces the degradation of KDM3A and KDM3B (Target protein ligand (Pink): HY-12304; linker (Black): HY-22335; Conjugate of E3 ligase ligand and linker: HY-112599; E3 ligase (Blue): HY-41547) .
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-
- HY-132296
-
|
|
FAK
PROTACs
|
Cancer
|
|
GSK215 is a potent and selective PROTAC focal adhesion kinase (FAK) degrader with a pDC50 of 8.4. GSK215 is designed by a binder for the VHL E3 ligase and the FAK inhibitor VS-4718. GSK215 induces rapid and prolonged FAK degradation, giving a long-lasting effect on FAK levels and a marked pharmacokinetic/pharmacodynamics (PK/PD) disconnect .
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-
- HY-159732
-
|
|
Histone Methyltransferase
|
Cancer
|
|
PRMT3-IN-4 (intermediate 15) is a protein arginine methyltransferase 3 (PRMT3) inhibitor. PRMT3-IN-4 is an active control for HY-19715. PRMT3-IN-4 can be used to synthesize PROTACs targeting PRMT3. PRMT3-IN-4 can be used in leukemia-related research .
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-
- HY-103602B
-
|
VH032-PEG3-NH2 dihydrochloride; VHL Ligand-Linker Conjugates 1 dihydrochloride; E3 ligase Ligand-Linker Conjugates 5 dihydrochloride
|
E3 Ligase Ligand-Linker Conjugates
|
Cancer
|
|
(S,R,S)-AHPC-PEG3-NH2 dihydrochloride (VH032-PEG3-NH2 dihydrochloride) is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 3-unit PEG linker used in PROTAC technology
|
-
- HY-168318
-
|
|
E3 Ligase Ligand-Linker Conjugates
|
Cancer
|
|
Bestatin-amide-PEG3-CH2-acid is an E3 ligase ligand-linker conjugate. Bestatin-amide-PEG3-CH2-acid can be used to synthesize PROTAC RAR Degrader-1 (HY-111844) .
|
-
- HY-130387
-
|
|
PROTAC Linkers
ADC Linker
|
Cancer
|
|
Propargyl-PEG4-Tos is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Propargyl-PEG4-Tos is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Propargyl-PEG4-Tos is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
-
- HY-118808
-
|
|
ADC Linker
PROTAC Linkers
|
Cancer
|
|
Propargyl-PEG2-NHBoc is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Propargyl-PEG2-NHBoc is a PEG-based PROTAC linker can be used in the synthesis of PROTACs . Propargyl-PEG2-NHBoc is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
-
- HY-126976
-
|
|
ADC Linker
PROTAC Linkers
|
Cancer
|
|
Propargyl-PEG5-amine is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Propargyl-PEG5-amine is a PEG-based PROTAC linker can be used in the synthesis of PROTACs . Propargyl-PEG5-amine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
-
- HY-130521
-
|
Cereblon Ligand-Linker Conjugates 22; E3 ligase Ligand-Linker Conjugates 55
|
E3 Ligase Ligand-Linker Conjugates
|
Cancer
|
|
Pomalidomide-amido-PEG3-C2-NH2 (Cereblon Ligand-Linker Conjugates 22) is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 3-unit PEG linker used in PROTAC technology .
|
-
- HY-130988
-
|
GDC-0068-NH2; RG7440-NH2
|
Ligands for Target Protein for PROTAC
|
Cancer
|
|
Ipatasertib-NH2 (GDC-0068-NH2;RG7440-NH2) is a ligand for target protein AKT for PROTAC (INY-03-041). INY-03-041 is composed of Ipatasertib-NH2, a ten-hydrocarbon linker, and a CRBN ligand Lenalidomide for E3 ubiquitin ligase .
|
-
- HY-156568
-
|
|
PROTACs
Epigenetic Reader Domain
|
Cancer
|
|
SMD-3040 is a potent and selective of SMARCA2 PROTAC degrader (DC50: 12 nM). SMD-3040 contains SMARCA2/4 ligand, linker and VHL ligand. SMD-3040 demonstrates excellent degradation selectivity for SMARCA2 protein over SMARCA4 protein.SMD-3040 achieves strong tumor growth inhibition in xenograft models .
|
-
- HY-163210
-
|
|
Ligands for E3 Ligase
|
Cancer
|
|
Pomalidomide 5'-fluoro-6'-piperazine-4-methylpiperidine hydrochloride (ZJT1) is an E3 ubiquitin ligase cereblon based on Pomalidomide (HY-10984) (CRBN) ligand for recruitment of cereblon protein. Pomalidomide 5'-fluoro-6'-piperazine-4-methylpiperidine hydrochloride can be linked to protein ligand by linker to form PROTAC .
|
-
- HY-161574
-
|
|
PROTACs
Histone Methyltransferase
|
Cancer
|
|
LLC0424 is a potent and selective cereblon-based PROTAC nuclear receptor-binding SET domain-containing 2 (NSD2) degrader. LLC0424 effectively degraded NSD2 with a DC50 of 20 nM in RPMI-8402 cells. LLC0424 selectively induces NSD2 degradation in a cereblon- and proteasome-dependent fashion. (Blue: CRBN ligand (HY-14658), Black: linker (HY-40002); Pink: NSD2 inhibitor (HY-161575)) .
|
-
- HY-139335
-
|
|
E3 Ligase Ligand-Linker Conjugates
|
Cancer
|
|
VH 101 phenol-alkylC4-amine dihydrochloride is a von-Hippel-Lindau protein ligand (VHL), and incorporates an E3 ligase ligand plus an alkylC4 linker. VH 101 phenol-alkylC4-amine dihydrochloride can be used for PROTAC research extracted from patent WO2022051326A1.
|
-
- HY-126885
-
|
|
ADC Linker
PROTAC Linkers
|
Cancer
|
|
DBCO-PEG5-NHS ester is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. DBCO-PEG5-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . DBCO-PEG5-NHS ester is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
|
-
- HY-W051634
-
|
|
ADC Linker
PROTAC Linkers
|
Cancer
|
|
Propargyl-PEG2-amine is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Propargyl-PEG2-amine is a PEG-based PROTAC linker can be used in the synthesis of PROTACs . Propargyl-PEG2-amine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
-
- HY-168304
-
|
|
E3 Ligase Ligand-Linker Conjugates
|
Cancer
|
|
(R)-Thalidomide-pyrrolidine-C-piperidine-Ph-NH2 is the E3 ubiquitin ligase ligand and linker of PROTAC (R)-NX-2127 (HY-153220A), which can be used in cancer research .
|
-
- HY-162362
-
|
|
PROTACs
GLP Receptor
|
Cancer
|
|
MS8709 (compound 10), a potential anticancer therapeutic, is a first-in-class G9a/GLP PROTAC degrader. MS8709 is based on G9a/GLP inhibitor UNC0642 and recruits the von Hippel Lindau (VHL) E3 ligase (Red: G9a/GLP inhibitor UNC0642; Blue: VHL ligand; Black: linker) .
|
-
- HY-168690
-
|
|
E3 Ligase Ligand-Linker Conjugates
|
Cancer
|
|
6-Aminocaproic acid-(S,R,S)-AHPC-Me is a ligand and linker for the E3 ubiquitin ligase of PROTAC, which can be used to synthesize PVD-06 (HY-149760) and is used in tumor research .
|
-
- HY-136186A
-
|
VH032-C7-amine dihydrochloride
|
E3 Ligase Ligand-Linker Conjugates
|
Cancer
|
|
(S,R,S)-AHPC-C7-amine dihydrochloride is the dihydrochloride form of (S,R,S)-AHPC-C7-amine (HY-136186). (S,R,S)-AHPC-C7-amine is a synthesized E3 ligase ligand-linker conjugate that incorporates the VH032 based VHL ligand and a linker. (S,R,S)-AHPC-C7-amine can be used for estrogen-related receptor α (ERRα) PROTAC degrader .
|
-
- HY-141438
-
SIM1
1 Publications Verification
|
PROTACs
Epigenetic Reader Domain
|
Cancer
|
|
SIM1 is a potent von Hippel-Lindau (VHL)-based trivalent PROTAC capable of degradation for all BET family members, with preference for BRD2 degradation (IC50=1.1 nM; Kd=186 nM). SIM1 shows sustained anti-cancer activity .
|
-
- HY-169358
-
|
|
PROTACs
Epigenetic Reader Domain
|
Cancer
|
|
L134 is a potent PROTAC BRD4 degrader with a DC50 value of 7.36 nM. L134 mediates the degradation of BRD4 via the ubiquitin-proteasome system in a DCAF11-dependent manner (Blue: JQ-1 (carboxylic acid) (HY-78695), Black: linker (HY-W004640); Pink: E3 ligase ligand, L321 (HY-169359)) .
|
-
- HY-114312
-
MD-224
5 Publications Verification
|
PROTACs
MDM-2/p53
E1/E2/E3 Enzyme
|
Cancer
|
|
MD-224 is a first-in-class and highly potent small-molecule human murine double minute 2 (MDM2) degrader based on the proteolysistargeting chimera (PROTAC) concept. MD-224 consists of ligands for Cereblon and MDM2. MD-224 induces rapid degradation of MDM2 at concentrations <1 nM in human leukemia cells, and achieves an IC50 value of 1.5 nM in inhibition of growth of RS4;11 cells. MD-224 has the potential to be a new class of anticancer agent . MD-224 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
-
- HY-155815
-
|
|
Histone Methyltransferase
PROTACs
|
Cancer
|
|
MS9715 is a potent and seletive NSD3-targeting PROTAC. MS9715 is designed by BI-9321, which binds NSD3’s PWWP1 domain, with an E3 ligase VHL ligand. MS9715 has the potental for NSD3-dependent cancer treatment research .
|
-
- HY-134592
-
-
- HY-161209
-
|
|
Ligands for E3 Ligase
Autophagy
|
Cancer
|
|
Thalidomide-2,6-diazaspiro[3.4]octane-C-Pip-boc is a conjugate of E3 ligase ligand and linker, consisting of Thalidomide (HY-14658) and the corresponding Linker. Thalidomide-2,6-diazaspiro[3.4]octane-C-Pip-boc can serve as a Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.
|
-
![Thalidomide-2,6-diazaspiro[3.4]octane-C-Pip-boc](//file.medchemexpress.com/product_pic/hy-161209.gif)
- HY-163225
-
|
|
Ligands for E3 Ligase
Autophagy
|
Cancer
|
|
(S)-Thalidomide-piperazine-(1S,4r)-cyclohexane-NH-Boc is a conjugate of E3 ligase ligand and linker, consisting of Thalidomide (HY-14658) and the corresponding Linker. (S)-Thalidomide-piperazine-(1S,4r)-cyclohexane-NH-Boc can serve as a Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.
|
-
- HY-170669
-
|
|
PROTACs
CRM1
Apoptosis
NF-κB
|
Cancer
|
|
PROTAC XPO1 degrader-1 (Compound 2c) is an XPO1 degrader. PROTAC XPO1 degrader-1 exhibits anti-proliferative effects, can induce cell apoptosis, inhibit NF-κB activity, and cause cell cycle arrest in the G1 phase. PROTAC XPO1 degrader-1 can be used in research on hematological malignancies (Pink: Target Protein Ligand (HY-170672); Black: Linker (HY-W010525); Blue: E3 Ligase Ligand (HY-170671); E3 Ligase Ligand-Linker Conjugate (HY-170673)) .
|
-
- HY-131865
-
|
|
PROTACs
EGFR
|
Others
|
|
SJF-1521 is a selective EGFR PROTAC degrader. SJF-1521 contains the EGFR inhibitor lapatinib (HY-50898). SJF-1521 can induce EGFR degradation in OVCAR8 cells .
|
-
- HY-42489
-
|
|
ADC Linker
PROTAC Linkers
|
Cancer
|
|
N3-PEG3-CH2CH2-Boc is a cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . N3-PEG3-CH2CH2-Boc is also a PEG- and Alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs . N3-PEG3-CH2CH2-Boc is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
|
-
- HY-115881
-
|
|
PROTACs
|
Cancer
|
|
SR-1114 is a first-in-class PROTAC ENL degrader. SR-1114 elicits rapid, CRBN-dependent degradation of ENL with DC50s of 150 nM, 311 nM, and 1.65 μM in MV4;11 , MOLM-13, and OCI/AML-2 cells, respectively .
|
-
- HY-172145
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E3 Ligase Ligand-Linker Conjugates
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Cancer
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Thalidomide-O-COOH-NH2-C2-PEG2-NH-Boc is a conjugate of E3 ligase ligand and linker, which contains Thalidomide-based CEREBLON ligand and PEG inker. Thalidomide-O-COOH-NH2-C2-PEG2-NH-Boc can be used to synthesize PROTAC degrader JB300 (HY-137341) .
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- HY-138550A
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E3 Ligase Ligand-Linker Conjugates
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Cancer
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(S,R,S)-AHPC-3-methylbutanyl acetate-methanesulfonothioate-PEG3-NH2 TFA is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based ligand and 3-unit PEG linker used in PROTAC technology .
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- HY-125834
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PROTACs
Bcr-Abl
Apoptosis
STAT
JAK
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Cancer
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GMB-475 is a potent BCR-ABL1 PROTAC based on Von Hippel-Lindau (VHL). GMB-475 targets the nutmeg pocket of ABL1 in an ectopic manner and degrades BCR-ABL1 protein through the ubiquitin proteasome pathway. GMB-475 inhibits the proliferation of human K562 cells and mouse Ba/F3 cells, and is used for the study of chronic myeloid leukemia. (Blue: VHL ligand (HY-125845); Black: Linker; Pink: BCR-ABL1 ligand (HY-11007)) .
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- HY-153519
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Epigenetic Reader Domain
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Cancer
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WWL0245 is a potent and seletive BRD4 PROTAC. WWL0245 selectively degrades BRD4 with sub-nanomolar DC50 (<1 nM) than BRD2/3 and PLK1 ( DC50>1 μM). WWL0245 shows excellent selective cytotoxicity in the BETi sensitive cancer cell lines, including AR-positive prostate cancer cell lines. WWL0245 is a promising drug candidate for AR-positive prostate cancer research and a valuable tool compound to study the biological function of BRD4 .
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- HY-153342
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ARV-766
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PROTACs
Androgen Receptor
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Cancer
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Luxdegalutamide (ARV-766) is an orally active protein hydrolysis targeted chimeric (PROTAC) targeting androgen receptor (AR), which can degrade AR resistance related mutants, including T878/H875/L702 mutants. Luxdegalutamide has anti-tumor activity and can be used in the study of castration resistant prostate cancer .
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- HY-161806
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PROTACs
Dengue Virus
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Infection
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ZXH-8-004 (2-12-2-deg) is a potent DENV E PROTAC degrader with an DC50 value of 0.21 µM. ZXH-8-004 shows exhibit antiviral potencies (Blue: E3 ligase (HY-103596), Black: linker (HY-42149); Pink: DENV E ligand (HY-161807)) .
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- HY-162250
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PROTACs
Histone Methyltransferase
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Cancer
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MS8847 is a highly potent EZH2 PROTAC degrader that recruits the E3 ligase von Hippel-Lindau (VHL). MS8847 potently degrades EZH2 in a ubiquitin-proteasome system-dependent manner. MS8847 effectively inhibits the growth of acute myeloid leukemia (AML) and triple-negative breast cancer (TNBC) cells .
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- HY-149433
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Androgen Receptor
Apoptosis
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Cancer
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BWA-522 is an orally available small molecule protein-targeting chimera (PROTACs) with significant degradation effect on AR-FL and AR-V7. BWA-522 antagonizes the N-terminal domain (AR-NTD) of the androgen receptor (Androgen Receptor) and induces apoptosis in PC cells. BWA-522 inhibits tumor growth in LNCaP xenograft model studies (60 mg/kg, po; TGI=76%). The efficiencies of BWA-522 in degrading AR-V7 and AR-FL were 77.3% (1 μM) and 72.0% (5 μM) in VCaP and LNCaP cells, respectively .
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- HY-145177
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E3 Ligase Ligand-Linker Conjugates
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Cancer
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Thalidomide-O-amido-CH2-PEG3-CH2-NH-Boc is a synthesized E3 ligase ligand-linker conjugate. Thalidomide-O-amido-CH2-PEG3-CH2-NH-Boc incorporates the Thalidomide based cereblon ligand and a linker. Thalidomide-O-amido-CH2-PEG3-CH2-NH-Boc can be used for the synthesis of PROTAC BET degrader . (From patent WO2017180417A1 compound s7).
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- HY-130683
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E3 Ligase Ligand-Linker Conjugates
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Cancer
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Lenalidomide-propargyl-C2-NH2 hydrochloride incorporates a cereblon (CRBN) ligand for the E3 ubiquitin ligase, and a linker. Lenalidomide-propargyl-C2-NH2 hydrochloride can be used to design the PROTAC MD-224 (HY-114312) . Lenalidomide-propargyl-C2-NH2 (hydrochloride) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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- HY-158684
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PROTACs
MDM-2/p53
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Cancer
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YX-02-030M is a PROTAC MDM2 degrader. YX-02-030M inhibits MDM2-p53 binding and VHL-HIF1α binding with IC50s of 63 nM and 1.35 μM respectively. YX-02-030M binds MDM2 and recruits the VHL E3 ubiquitin ligase to initiate MDM2 degradation, and effectively kills p53 mutant or deleted Triple-negative breast cancers (TNBC) cells. (Blue: VHL ligand; Black: linker; Pink: MDM2 inhibitor) .
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- HY-145281
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PROTACs
Akt
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Cancer
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MS98 is a potent and selective PROTAC AKT degrader. MS98 depletes cellular total AKT (T-AKT) with the DC50 value of 78 nM. MS98 binds to AKT1, AKT2, and AKT3 with Kds of 4 nM, 140 nM, and 8.1 nM, respectively .
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- HY-144323
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PROTACs
PERK
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Cancer
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YF135 is an efficient and reversible-covalent KRAS G12C PROTAC. YF135 is designed and synthesized by tethering KRAS G12C inhibitor 48 (compound 6d) as the ligand, and basing on the scaffold of MRTX849 linkage VHL ligand. YF135 significantly induces the degradation of KRAS G12C in a reversible manner and decreases phospho-ERK level through the E3 ligase VHL mediated proteasome pathway .
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- HY-136055
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VH032-C5-COOH
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E3 Ligase Ligand-Linker Conjugates
HIF/HIF Prolyl-Hydroxylase
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Cancer
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(S,R,S)-AHPC-C5-COOH (VH032-C5-COOH) is a synthesized E3 ligase ligand-linker conjugate, contains the VH032 VHL-based ligand and a linker to form PROTACs. VH-032 is a selective and potent inhibitor of VHL/HIF-1α interaction with a Kd of 185 nM, has the potential for the study of anemia and ischemic diseases .
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- HY-140310
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ADC Linker
PROTAC Linkers
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Cancer
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TCO-PEG4-DBCO is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. TCO-PEG4-DBCO is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . TCO-PEG4-DBCO is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups. TCO-PEG4-DBCO also contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.
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- HY-130682
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E3 Ligase Ligand-Linker Conjugates
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Cancer
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Lenalidomide-propargyl-C2-amido-Ph-NH2 hydrochloride incorporates a cereblon (CRBN) ligand for the E3 ubiquitin ligase and a linker. Lenalidomide-propargyl-C2-amido-Ph-NH2 hydrochloride can be used to design the PROTAC MD-224 (HY-114312) . Lenalidomide-propargyl-C2-amido-Ph-NH2 (hydrochloride) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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- HY-145226
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PROTACs
Epigenetic Reader Domain
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Cancer
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XY-06-007 is a selective and potent bump-and-hole (B&H)-PROTAC BRD4BD1L94V degrader. XY-06-007 shows a DC50, 6 h of 10 nM against BRD4BD1L94V with no degradation of off-targets. XY-06-007 demonstrates suitable pharmacokinetics for in vivo studies .
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- HY-145282
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MS170
1 Publications Verification
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PROTACs
Akt
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Cancer
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MS170 is a potent and selective PROTAC AKT degrader. MS170 depletes cellular total AKT (T-AKT) with the DC50 value of 32 nM. MS170 binds to AKT1, AKT2, and AKT3 with Kds of 1.3 nM, 77 nM, and 6.5 nM, respectively .
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- HY-157749
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Ligands for E3 Ligase
Autophagy
E3 Ligase Ligand-Linker Conjugates
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Cancer
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Thalidomide-piperazine-(S)-CH2-Pyrrolidine-C2-O-CH2-COO-C (CH3)3 is a synthetic E3 ligase ligand-Linker conjugate. Thalidomide-piperazine-(S)-Ch2-Pyrrolidine-C2-O-CH2-COO-C(CH3)3 includes Thalidomide-based cereblon ligands and linkers. Thalidomide-piperazine-(S)-CH2-Pyrrolidine-C2-O-CH2-COO-C(CH3)3 can be used to synthesize PROTAC BET .
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- HY-153337A
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E3 Ligase Ligand-Linker Conjugates
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Cancer
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Pomalidomide-C11-NH2 hydrochloride is the Pomalidomide-based cereblon (CRBN) ligand used in the recruitment of CRBN protein.Pomalidomide-C11-NH2 hydrochloride can be connected to the ligand for protein by a linker to form PROTAC .
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- HY-155258
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E3 Ligase Ligand-Linker Conjugates
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Cancer
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Pomalidomide-PEG7-NH2 hydrochloride is the Pomalidomide-based cereblon (CRBN) ligand used in the recruitment of CRBN protein.Pomalidomide-PEG7-NH2 hydrochloride can be connected to the ligand for protein by a linker to form PROTAC .
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- HY-147025
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PROTACs
TGF-beta/Smad
HIF/HIF Prolyl-Hydroxylase
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Inflammation/Immunology
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(S,R,S)-AHPC-C2-amide-benzofuranylmethyl-pyridine is a dual target PROTAC that can not only target to the ubiquitination and degradation of Smad3 but also improve the HIF-α protein level. (S,R,S)-AHPC-C2-amide-benzofuranylmethyl-pyridine has a multi-path anti-fibrosis function and a renal protection function for research of renal anemia .
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- HY-141512
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JB170
1 Publications Verification
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PROTACs
Aurora Kinase
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Cancer
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JB170 is a potent and highly specific PROTAC-mediated AURORA-A (Aurora Kinase) degrader (DC50=28 nM) by linking Alisertib, to the Cereblon-binding molecule Thalidomide. JB170 preferentially binds AURORA-A (EC50=193 nM) over AURORA-B (EC50=1.4 µM). JB170-mediated S-phase arrest is caused specifically by AURORA-A depletion. JB170 has excellent ability to inhibit non-catalytic function of AURORA-A kinase .
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- HY-122582
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PROTACs
Anaplastic lymphoma kinase (ALK)
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Cancer
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TL13-12 is a potent and selective?ALK-PROTAC?degrader and inhibits?ALK?activity with an IC50 value of 0.69 nM. TL13-12 also prompts the degradation of additional kinases including Aurora A, FER, PTK2, and RPS6KA1 with IC50 values of 13.5 nM, 5.74 nM, 18.4 nM, and 65 nM, respectively. TL13-12 is comprised of the conjugation of TAE684 (HY-10192) and the Cereblon ligand of Pomalidomide (HY-10984) .
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- HY-161710
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PROTACs
Epigenetic Reader Domain
Histone Acetyltransferase
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Cancer
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XYD129 is an effective CBP/p300 PROTAC degrader. XYD129 has antiproliferative activity on MV4-11 cell line (IC 50=0.044 μM). XYD129 can be used for the study of acute myeloid leukemia (AML). (Structure Note: Pink, CBP/p300 ligand 5 (HY-161711); Blue, E3 ligase ligand (HY-41547); Black, Linker (HY-40178)) .
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- HY-152154
-
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PROTACs
NAMPT
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Cancer
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|
Nampt degrader-2 is a fluorescent PROTAC, which efficiently degrades NAMPT with an IC50 of 41.9 nM. Nampt degrader-2 binds to NAMPT and VHL to form a ternary complex and subsequently induced NAMPT degradation via ubiquitin-proteasome system (UPS). Nampt degrader-2 leads to significant reduction of NAD + and exerts potent antitumor activities .
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- HY-169074
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E3 Ligase Ligand-Linker Conjugates
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Cancer
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|
Thalidomide-N-methylpiperazine is an E3 Ligase Ligand-Linker Conjugate. Thalidomide-N-methylpiperazine can be used to synthesize PROTAC MLKL Degrader-2 (HY-169072) to exhibit antinecroptotic activity on human cell lines and effectively degrade MLKL in the HT-29 xenograft mouse model .
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- HY-156401
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PROTACs
Epigenetic Reader Domain
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Cancer
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|
BRD9 Degrader-1 (Compound 13-7) is a PROTAC BRD9 degrader . BRD9 Degrader-1 has a micromolar binding affinity for BRD9 and a nanomolar affinity for the BRD9-VCB ternary complex. BRD9 Degrader-1 induces BRD9 proteasome degradation in HEK293T cells, which can be reversed by MLN4924 (HY-70062)。(Blue: VH032-cyclopropane-F (HY-125905); Black: linker (HY-W763939); Pink: HY-168695) .
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- HY-130965B
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E3 Ligase Ligand-Linker Conjugates
Autophagy
Apoptosis
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Cancer
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Thalidomide-PEG3-NH2 hydrochloride is the Thalidomide (HY-10984)-based cereblon ligand used in the recruitment of CRBN protein.Thalidomide-PEG3-NH2 hydrochloride can be connected to the ligand for protein by a linker to form PROTACs .
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- HY-130854
-
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E3 Ligase Ligand-Linker Conjugates
Autophagy
Apoptosis
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Cancer
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Thalidomide-NH-C6-NH-Boc is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used for MI-389 (compound 22) synthesis. MI-389 is a potent phthalimide PROTAC degrader based on the multi-targeted receptor tyrosine kinase inhibitor sunitinib (HY-10255A) .
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- HY-168634
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PROTACs
Epigenetic Reader Domain
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Cancer
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SJ46421 is a (+)-JQ-1 (HY-13030) based KLHDC2-BRD3 PROTAC protein degrader. SJ46421 induces cooperative ternary complexes with KLHDC2 and BRD3BD2, with an IC50 of 7.8 nM. SJ46421 selectively inhibits KLHDC2 substrate ubiquitylation. SJ46421 promotes polyubiquitylation of the BD2 domain from BRD2, BRD3, or BRD4. SJ46421 possesses poor cell permeability. (Pink: ligand for target protein (HY-13030); Black: linker (HY-20797); Blue: E3 ligase ligand (HY-168536)) .
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- HY-156159
-
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Ligands for E3 Ligase
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Cancer
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Thalidomide-NH-C9-NH2 hydrochloride is the Thalidomide (HY-10984)-based cereblon ligand used in the recruitment of CRBN protein.Thalidomide-NH-C9-NH2 hydrochloride can be connected to the ligand for protein by a linker to form PROTACs .
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- HY-156172
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Ligands for E3 Ligase
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Cancer
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Thalidomide-NH-PEG6-NH2 hydrochloride is the Thalidomide (HY-10984)-based cereblon ligand used in the recruitment of CRBN protein.Thalidomide-NH-PEG6-NH2 hydrochloride can be connected to the ligand for protein by a linker to form PROTACs .
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- HY-156161
-
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Ligands for E3 Ligase
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Cancer
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Thalidomide-NH-C13-NH2 hydrochloride is the Thalidomide (HY-10984)-based cereblon ligand used in the recruitment of CRBN protein.Thalidomide-NH-C13-NH2 hydrochloride can be connected to the ligand for protein by a linker to form PROTACs .
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- HY-156160
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Ligands for E3 Ligase
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Cancer
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Thalidomide-NH-C10-NH2 hydrochloride is the Thalidomide (HY-10984)-based cereblon ligand used in the recruitment of CRBN protein.Thalidomide-NH-C10-NH2 hydrochloride can be connected to the ligand for protein by a linker to form PROTACs .
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- HY-155263
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E3 Ligase Ligand-Linker Conjugates
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Cancer
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Pomalidomide-5-C7-NH2 hydrochloride is the Pomalidomide-based cereblon (CRBN) ligand used in the recruitment of CRBN protein. Pomalidomide-5-C7-NH2 hydrochloride can be connected to the ligand for protein by a linker to form PROTAC .
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-
- HY-155267
-
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E3 Ligase Ligand-Linker Conjugates
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Cancer
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Pomalidomide-5-C11-NH2 hydrochloride is the Pomalidomide-based cereblon (CRBN) ligand used in the recruitment of CRBN protein.Pomalidomide-5-C11-NH2 hydrochloride can be connected to the ligand for protein by a linker to form PROTAC .
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-
- HY-155270
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E3 Ligase Ligand-Linker Conjugates
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Cancer
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Pomalidomide-5-C14-NH2 hydrochloride is the Pomalidomide-based cereblon (CRBN) ligand used in the recruitment of CRBN protein. Pomalidomide-5-C14-NH2 hydrochloride can be connected to the ligand for protein by a linker to form PROTAC .
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-
- HY-155268
-
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E3 Ligase Ligand-Linker Conjugates
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Cancer
|
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Pomalidomide-5-C12-NH2 hydrochloride is the Pomalidomide-based cereblon (CRBN) ligand used in the recruitment of CRBN protein.Pomalidomide-5-C12-NH2 hydrochloride can be connected to the ligand for protein by a linker to form PROTAC .
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-
- HY-155265
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E3 Ligase Ligand-Linker Conjugates
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Cancer
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Pomalidomide-5-C9-NH2 hydrochloride is the Pomalidomide-based cereblon (CRBN) ligand used in the recruitment of CRBN protein.Pomalidomide-5-C9-NH2 hydrochloride can be connected to the ligand for protein by a linker to form PROTAC .
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-
- HY-155266
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E3 Ligase Ligand-Linker Conjugates
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Cancer
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Pomalidomide-5-C10-NH2 hydrochloride is the Pomalidomide-based cereblon (CRBN) ligand used in the recruitment of CRBN protein.Pomalidomide-5-C10-NH2 hydrochloride can be connected to the ligand for protein by a linker to form PROTAC .
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-
- HY-148662
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E3 Ligase Ligand-Linker Conjugates
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Cancer
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Pomalidomide-PEG5-C2-NH2 hydrochloride is the Pomalidomide-based cereblon (CRBN) ligand used in the recruitment of CRBN protein.Pomalidomide-PEG5-C2-NH2 hydrochloride can be connected to the ligand for protein by a linker to form PROTAC .
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-
- HY-144691
-
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PROTACs
CDK
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Cancer
|
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PP-C8 is a potent and selective PROTAC CDK12-Cyclin K degrader. PP-C8 induces CDK12-Cyclin K degradation with DC50s of 416 and 412 nM for CDK12 and Cyclin K, respectively. PP-C8 demonstrates profound synergistic antiproliferative effects with PARP inhibitor in triple-negative breast cancer (TNBC) .
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- HY-168637
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PROTACs
Ras
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Cancer
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SIAIS562055 is a potent cereblon-based SOS1 PROTAC with a Kd of 95.9 nM. SIAIS562055 exhibits sustained degradation of SOS1 and inhibition of downstream ERK pathways. SIAIS562055 effectively blocked the binding of KRAS G12C or KRAS G12D to SOS1, with the IC50 values of 95.7 nM and 134.5 nM, respectively. SIAIS562055 exhibits potent anticancer activity. (Pink: SOS1 ligand (HY-168638); Black: linker (HY-W539874); Blue: E3 ligase ligand (HY-W076696)) .
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- HY-145388
-
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PROTACs
Epigenetic Reader Domain
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Cancer
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AU-15330 is a proteolysis-targeting chimera (PROTAC) degrader of the SWI/SNF ATPase subunits, SMARCA2 and SMARCA4. AU-15330 induces potent inhibition of tumour growth in xenograft models of prostate cancer and synergizes with the AR antagonist enzalutamide. AU-15330 induces disease remission in castration-resistant prostate cancer (CRPC) models without toxicity .
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- HY-155256
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Ligands for E3 Ligase
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Cancer
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Thalidomide-5-PEG6-NH2 hydrochloride is the Thalidomide (HY-10984)-based cereblon ligand used in the recruitment of CRBN protein.Thalidomide-5-PEG6-NH2 hydrochloride can be connected to the ligand for protein by a linker to form PROTACs .
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-
- HY-155255
-
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Ligands for E3 Ligase
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Cancer
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Thalidomide-5-PEG2-NH2 hydrochloride is the Thalidomide (HY-10984)-based cereblon ligand used in the recruitment of CRBN protein.Thalidomide-5-PEG2-NH2 hydrochloride can be connected to the ligand for protein by a linker to form PROTACs .
|
-
- HY-155257
-
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Ligands for E3 Ligase
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Cancer
|
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Thalidomide-5-PEG7-NH2 hydrochloride is the Thalidomide (HY-10984)-based cereblon ligand used in the recruitment of CRBN protein.Thalidomide-5-PEG7-NH2 hydrochloride can be connected to the ligand for protein by a linker to form PROTACs .
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-
- HY-146393
-
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PROTACs
Cytochrome P450
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Cancer
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PROTAC CYP1B1 degrader-1 (Compound 6C), a α-naphthoflavone chimera derivative, is able to eliminate cytochrome P450 (CYP)1B1-mediated agent resistance via targeted CYP1B1 degradation, with IC50s of 95.1 and 9838.6 nM for CYP1B1 and CYP1A2, respectively. PROTAC CYP1B1 degrader-1 can be used for the research of CYP1B1-overexpressing prostate cancer .
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- HY-149569
-
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Ligands for E3 Ligase
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Cancer
|
|
Thalidomide-5-O-C12-NH2 hydrochloride is the Thalidomide (HY-10984)-based cereblon ligand used in the recruitment of CRBN protein.Thalidomide-5-O-C12-NH2 hydrochloride can be connected to the ligand for protein by a linker to form PROTACs .
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-
- HY-149576
-
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Ligands for E3 Ligase
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Cancer
|
|
Thalidomide-4-O-C14-NH2 hydrochloride is the Thalidomide (HY-10984)-based cereblon ligand used in the recruitment of CRBN protein.Thalidomide-4-O-C14-NH2 hydrochloride can be connected to the ligand for protein by a linker to form PROTACs .
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- HY-156170
-
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Ligands for E3 Ligase
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Cancer
|
|
Thalidomide-5-NH-PEG5-NH2 hydrochloride is the Thalidomide (HY-10984)-based cereblon ligand used in the recruitment of CRBN protein. Thalidomide-5-NH-PEG5-NH2 hydrochloride can be connected to the ligand for protein by a linker to form PROTACs .
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- HY-149566
-
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Ligands for E3 Ligase
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Cancer
|
|
Thalidomide-5-O-C9-NH2 hydrochloride is the Thalidomide (HY-10984)-based cereblon ligand used in the recruitment of CRBN protein.Thalidomide-5-O-C9-NH2 hydrochloride can be connected to the ligand for protein by a linker to form PROTACs .
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- HY-149561
-
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Ligands for E3 Ligase
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Cancer
|
|
Thalidomide-5-O-C4-NH2 hydrochloride is the Thalidomide (HY-10984)-based cereblon ligand used in the recruitment of CRBN protein.Thalidomide-5-O-C4-NH2 hydrochloride can be connected to the ligand for protein by a linker to form PROTACs .
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-
- HY-149567
-
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Ligands for E3 Ligase
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Cancer
|
|
Thalidomide-5-O-C10-NH2 hydrochloride is the Thalidomide (HY-10984)-based cereblon ligand used in the recruitment of CRBN protein.Thalidomide-5-O-C10-NH2 hydrochloride can be connected to the ligand for protein by a linker to form PROTACs .
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-
- HY-156171
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Ligands for E3 Ligase
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Cancer
|
|
Thalidomide-5-NH-PEG6-NH2 hydrochloride is the Thalidomide (HY-10984)-based cereblon ligand used in the recruitment of CRBN protein.Thalidomide-5-NH-PEG6-NH2 hydrochloride can be connected to the ligand for protein by a linker to form PROTACs .
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-
- HY-149564
-
|
|
Ligands for E3 Ligase
|
Cancer
|
|
Thalidomide-5-O-C7-NH2 hydrochloride is the Thalidomide (HY-10984)-based cereblon ligand used in the recruitment of CRBN protein.Thalidomide-5-O-C7-NH2 hydrochloride can be connected to the ligand for protein by a linker to form PROTACs .
|
-
- HY-149574
-
|
|
Ligands for E3 Ligase
|
Cancer
|
|
Thalidomide-4-O-C12-NH2 hydrochloride is the Thalidomide (HY-10984)-based cereblon ligand used in the recruitment of CRBN protein.Thalidomide-4-O-C12-NH2 hydrochloride can be connected to the ligand for protein by a linker to form PROTACs .
|
-
- HY-149562
-
|
|
Ligands for E3 Ligase
|
Cancer
|
|
Thalidomide-5-O-C5-NH2 hydrochloride is the Thalidomide (HY-10984)-based cereblon ligand used in the recruitment of CRBN protein.Thalidomide-5-O-C5-NH2 hydrochloride can be connected to the ligand for protein by a linker to form PROTACs .
|
-
- HY-149575
-
|
|
Ligands for E3 Ligase
|
Cancer
|
|
Thalidomide-4-O-C13-NH2 hydrochloride is the Thalidomide (HY-10984)-based cereblon ligand used in the recruitment of CRBN protein.Thalidomide-4-O-C13-NH2 hydrochloride can be connected to the ligand for protein by a linker to form PROTACs .
|
-
- HY-130949B
-
|
|
Ligands for E3 Ligase
|
Cancer
|
|
Thalidomide-4-O-C7-NH2 hydrochloride is the Thalidomide (HY-10984)-based cereblon ligand used in the recruitment of CRBN protein.Thalidomide-4-O-C7-NH2 hydrochloride can be connected to the ligand for protein by a linker to form PROTACs .
|
-
- HY-130963B
-
|
|
E3 Ligase Ligand-Linker Conjugates
|
Cancer
|
|
Thalidomide-4-O-C10-NH2 hydrochloride is the Thalidomide (HY-10984)-based cereblon ligand used in the recruitment of CRBN protein.Thalidomide-4-O-C10-NH2 hydrochloride can be connected to the ligand for protein by a linker to form PROTACs .
|
-
- HY-149571
-
|
|
Ligands for E3 Ligase
|
Cancer
|
|
Thalidomide-5-O-C14-NH2 hydrochloride is the Thalidomide (HY-10984)-based cereblon ligand used in the recruitment of CRBN protein.Thalidomide-5-O-C14-NH2 hydrochloride can be connected to the ligand for protein by a linker to form PROTACs .
|
-
- HY-149573
-
|
|
Ligands for E3 Ligase
|
Cancer
|
|
Thalidomide-4-O-C11-NH2 hydrochloride is the Thalidomide (HY-10984)-based cereblon ligand used in the recruitment of CRBN protein.Thalidomide-4-O-C11-NH2 hydrochloride can be connected to the ligand for protein by a linker to form PROTACs .
|
-
- HY-149559
-
|
|
Ligands for E3 Ligase
|
Cancer
|
|
Thalidomide-5-O-C2-NH2 hydrochloride is the Thalidomide (HY-10984)-based cereblon ligand used in the recruitment of CRBN protein.Thalidomide-5-O-C2-NH2 hydrochloride can be connected to the ligand for protein by a linker to form PROTACs .
|
-
- HY-149565
-
|
|
Ligands for E3 Ligase
|
Cancer
|
|
Thalidomide-5-O-C8-NH2 hydrochloride is the Thalidomide (HY-10984)-based cereblon ligand used in the recruitment of CRBN protein.Thalidomide-5-O-C8-NH2 hydrochloride can be connected to the ligand for protein by a linker to form PROTACs .
|
-
- HY-149560
-
|
|
Ligands for E3 Ligase
|
Cancer
|
|
Thalidomide-5-O-C3-NH2 hydrochloride is the Thalidomide (HY-10984)-based cereblon ligand used in the recruitment of CRBN protein.Thalidomide-5-O-C3-NH2 hydrochloride can be connected to the ligand for protein by a linker to form PROTACs .
|
-
- HY-149572
-
|
|
Ligands for E3 Ligase
|
Cancer
|
|
Thalidomide-4-O-C9-NH2 hydrochloride is the Thalidomide (HY-10984)-based cereblon ligand used in the recruitment of CRBN protein.Thalidomide-4-O-C9-NH2 hydrochloride can be connected to the ligand for protein by a linker to form PROTACs .
|
-
- HY-149570
-
|
|
Ligands for E3 Ligase
|
Cancer
|
|
Thalidomide-5-O-C13-NH2 hydrochloride is the Thalidomide (HY-10984)-based cereblon ligand used in the recruitment of CRBN protein.Thalidomide-5-O-C13-NH2 hydrochloride can be connected to the ligand for protein by a linker to form PROTACs .
|
-
- HY-149568
-
|
|
Ligands for E3 Ligase
|
Cancer
|
|
Thalidomide-5-O-C11-NH2 hydrochloride is the Thalidomide (HY-10984)-based cereblon ligand used in the recruitment of CRBN protein.Thalidomide-5-O-C11-NH2 hydrochloride can be connected to the ligand for protein by a linker to form PROTACs .
|
-
- HY-149563
-
|
|
Ligands for E3 Ligase
|
Cancer
|
|
Thalidomide-5-O-C6-NH2 hydrochloride is the Thalidomide (HY-10984)-based cereblon ligand used in the recruitment of CRBN protein.Thalidomide-5-O-C6-NH2 hydrochloride can be connected to the ligand for protein by a linker to form PROTACs .
|
-
- HY-168348
-
|
|
PROTAC Linkers
|
Others
|
|
(R)-4-(1-(Pyrrolidin-3-ylmethyl)piperidin-4-yl)aniline is a linker for NX-2127 (HY-153220A) .
|
-
- HY-162464
-
|
|
PROTACs
SARS-CoV
|
Infection
|
|
MPD2 is a Cereblon-binding ligand-based PROTAC that degrades MPro, the main protease of SARS-CoV-2. MPD2 effectively reduced MPro protein levels in 293T cells in a time-dependent manner (DC50=296 nM). MPD2 exhibited potent antiviral activity against multiple SARS-CoV-2 strains and had enhanced potency against Nirmatrelvir (HY-138687) resistant strains. MPD2 provides a new direction for antiviral drug development against SARS-CoV-2 and other emerging coronavirus pathogens (Sturcture Note:(Blue: Cereblon ligand (HY-14658), Black: linker (HY-W275882)；Red: SARS-CoV-2 MPro Inhibitor MP18 (HY-158763)) .
|
-
- HY-130652
-
|
|
E3 Ligase Ligand-Linker Conjugates
|
Cancer
|
|
Pomalidomide 4'-PEG3-azide is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide-based cereblon ligand and a linker. Pomalidomide 4'-PEG3-azide can be used for the synthesis of iRucaparib-TP3 (Compound 3). iRucaparib-TP3 is a highly efficient PARP1?degrader based on Rucaparib by using the PROTAC approach . Pomalidomide 4'-PEG3-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
|
-
- HY-161410
-
|
|
PROTACs
Apoptosis
Bcl-2 Family
|
Cancer
|
|
WH244 is a second generation BCL-2 and BCL-xL dual depressant (PROTAC). The primary activity of WH244 is the specific degradation of BCL-2 and BCL-xL proteins (BCL-xL: DC50=0.6 nM, BCL-2: DC50=7.4 nM). WH244 promotes their ubiquitination and subsequent proteasome degradation by targeting these proteins, thereby restoring the cell's apoptosis pathway. WH244 has good antitumor activity. (Pink: BCL-2/BCL-xL ligand (HY-161415); Blue: E3 ligase ligand (HY-112078); Black: linker) .
|
-
- HY-155269
-
|
|
E3 Ligase Ligand-Linker Conjugates
|
Cancer
|
|
Pomalidomide-5-C13-NH2 hydrochloride is a Pomalidomide (HY-10984)-based E3 ubiquitin ligase cereblon (CRBN) ligand for recruiting cereblon proteins. Pomalidomide-5-C13-NH2 hydrochloride can be connected to protein ligands through a linker to form PROTAC.
|
-
- HY-110167
-
|
|
PGE synthase
Ligands for Target Protein for PROTAC
|
Cancer
|
|
TFC-007, a selective hematopoietic prostaglandin D synthase (H-PGDS) inhibitor, show high inhibitory activity against H-PGDS enzyme (IC50 value of 83 nM). TFC-007 can be used for composing H-PGDS degradation inducer PROTAC(H-PGDS)-1 (TFC-007 binds to H-PGDS, and Pomalidomide binds to cereblon) .
|
-
- HY-155371
-
|
|
PROTACs
|
Others
|
|
BT-PROTAC is a bioorthogonally activatable prodrug. BT-PROTAC can accurately control the activity of PROTAC .
|
-
- HY-133487A
-
|
VH032-C8-NH2 hydrochloride
|
E3 Ligase Ligand-Linker Conjugates
|
Cancer
|
|
(S,R,S)-AHPC-C8-NH2 (VH032-C8-NH2) hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the VH032 based VHL ligand and a linker used in PROTAC technology .
|
-
- HY-161108
-
|
|
PROTACs
Checkpoint Kinase (Chk)
|
Cancer
|
|
PROTAC Chk1 degrader-1 (Compound PROTAC-2 ) is a potent PROTAC-targeted degrader of Chk1 with a DC50 of 1.33 μM. PROTAC Chk1 degrader-1 can be used in cancer research .
|
-
- HY-W017440
-
|
PROTAC Linker 25
|
PROTAC Linkers
|
Cancer
|
|
Triethylene glycol (PROTAC Linker 25) is a PEG-based PROTAC linker can be used in the synthesis of PROTACs .
|
-
- HY-W018745
-
|
PROTAC Linker 18
|
PROTAC Linkers
|
Cancer
|
|
Tetraethylene glycol (PROTAC Linker 18) is a PEG-based PROTAC linker can be used in the synthesis of PROTACs .
|
-
- HY-162876
-
|
|
Ligands for Target Protein for PROTAC
|
Cancer
|
|
PROTAC BRD4 ligand-3 is a PROTAC target protein ligand (Ligands for Target Protein for PROTACs). PROTAC BRD4 ligand-3 can be used for synthesis PROTAC BRD4 Degrader-27 (HY-162875) .
|
-
- HY-146346
-
|
|
PROTACs
HDAC
|
Inflammation/Immunology
|
|
HD-TAC7 is a potent PROTAC HDAC degrader with IC50 values of 3.6 μM, 4.2 μM and 1.1 μM for HDAC1, HDAC2 and HDAC3, respectively. HD-TAC7 can decreases NF-κB p65 in RAW 264.7 macrophages. HD-TAC7 can be used for the research of inflammatory diseases like asthma and chronic obstructive pulmonary disease (COPD) .
|
-
- HY-138642
-
|
ARV-471
|
PROTACs
Estrogen Receptor/ERR
|
Cancer
|
|
Vepdegestrant (ARV-471) is an orally active PROTAC estrogen receptor degrader against breast cancer. Vepdegestrant is a hetero-bifunctional molecule that facilitates the interactions between estrogen receptor alpha and an intracellular E3 ligase complex. Vepdegestrant leads to the ubiquitylation and subsequent degradation of estrogen receptors via the proteasome. Vepdegestrant robustly degrades ER in ER-positive breast cancer cell lines with a half-maximal degradation concentration (DC50) of about 2 nM .
|
-
- HY-75706
-
|
|
PARP
Ligands for Target Protein for PROTAC
|
Cancer
|
|
N-Descyclopropanecarbaldehyde Olaparib is an analogue of Olaparib (HY-10162) containing DOTA moiety. N-Descyclopropanecarbaldehyde Olaparib is a PARP inhibitor used for synthesizing novel dual EGFR and PARP PROTAC, DP-C-4 . N-Descyclopropanecarbaldehyde Olaparib can be radiolabeled F-18 or fluorophore for positron emission tomography (PET) or optical imaging in several types of tumor .
|
-
- HY-W004896
-
|
PROTAC Linker 11
|
PROTAC Linkers
|
Cancer
|
|
Boc-NH-PEG2 (PROTAC Linker 11) is a PEG-based PROTAC linker can be used in the synthesis of PROTACs .
|
-
- HY-W004816
-
|
PROTAC Linker 16
|
PROTAC Linkers
|
Cancer
|
|
Bis-Tos-PEG4 (PROTAC Linker 16) is a PEG-based PROTAC linker can be used in the synthesis of PROTACs .
|
-
- HY-W017772
-
|
PROTAC Linker 10
|
PROTAC Linkers
|
Cancer
|
|
Boc-NH-PEG3 (PROTAC Linker 10) is a PEG-based PROTAC linker can be used in the synthesis of PROTACs .
|
-
- HY-W025896
-
|
PROTAC Linker 12
|
PROTAC Linkers
|
Cancer
|
|
Boc-NH-PEG4 (PROTAC Linker 12) is a PEG-based PROTAC linker can be used in the synthesis of PROTACs .
|
-
- HY-138642A
-
|
(Rac)-ARV-471
|
Estrogen Receptor/ERR
PROTACs
|
Cancer
|
|
(Rac)-Vepdegestrant is the isomer of Vepdegestrant (HY-138642). Vepdegestrant ((R)-Lavandulol) is an orally active PROTAC estrogen receptor degrader against breast cancer. Vepdegestrant is a hetero-bifunctional molecule that facilitates the interactions between estrogen receptor alpha and an intracellular E3 ligase complex. Vepdegestrant leads to the ubiquitylation and subsequent degradation of estrogen receptors via the proteasome. Vepdegestrant robustly degrades ER in ER-positive breast cancer cell lines with a half-maximal degradation concentration (DC50) of about 2 nM .
|
-
- HY-122653
-
|
|
PROTACs
|
Cancer
|
|
CCT367766 is a potent and the third generation?heterobifunctional and Cereblon-based pirin targeting protein?degradation probe (PDP, or PROTAC), depletes pirin protein expression at low concentration. CCT367766 exhibits a moderate affinity for the CRBN-DDB1 complex with an?IC50?value of 490 nM. CCT367766 reveals a good affinity for the recombinant pirin and CRBN with?Kd?values of 55 nM and 120 nM, respectively. CCT367766 provides a potential chemical tool to study a largely unexplored protein .
|
-
- HY-122653A
-
|
|
PROTACs
|
Cancer
|
|
CCT367766 formic is a potent and the third generation heterobifunctional and Cereblon-based pirin targeting protein degradation probe (PDP, or PROTAC), depletes pirin protein expression at low concentration. CCT367766 formic exhibits a moderate affinity for the CRBN-DDB1 complex with an IC50 value of 490 nM. CCT367766 formic reveals a good affinity for the recombinant pirin and CRBN with Kd values of 55 nM and 120 nM, respectively. CCT367766 formic provides a potential chemical tool to study a largely unexplored protein .
|
-
- HY-43538
-
|
|
PROTAC Linkers
|
Cancer
|
|
5-Bromopentanoyl chloride is a PROTAC linker in PROTAC ATR degrader-2 (HY-161615), and can be used for synthesis of PROTACs .
|
-
- HY-144304
-
|
|
PROTACs
EGFR
|
Cancer
|
|
PROTAC EGFR degrader 2 is a potent PROTAC EGFR degrader. PROTAC EGFR degrader 2 exhibits excellent antiproliferative activity with IC50 of 4.0 nM and good EGFR degradation activity with DC50 of 36.51 nM. PROTAC EGFR degrader 2 can be used for the synthesis of nitroreductase (NTR)-responsive PROTAC .
|
-
- HY-128803
-
|
PROTAC Linker 7
|
PROTAC Linkers
|
Cancer
|
|
Tos-PEG4-NH-Boc (PROTAC Linker 7) is a PEG-based PROTAC linker can be used in the synthesis of PROTACs .
|
-
- HY-172125
-
|
|
PROTAC Linkers
|
Cancer
|
|
AMPRO-222 is a PROTAC linker that can act as a linker of PROTAC PROTAC BRD4 Degrader-29 (HY-172124) .
|
-
- HY-136269A
-
-
- HY-125907
-
|
PROTAC Linker 34
|
PROTAC Linkers
|
Cancer
|
|
Dox-Ph-PEG1-Cl (PROTAC Linker 34) is a PEG-based PROTAC linker can be used in the synthesis of PROTACs .
|
-
- HY-136269
-
|
|
E3 Ligase Ligand-Linker Conjugates
|
Cancer
|
|
A 410099.1, amine-Boc hydrochloride is a functionalized IAP ligand and can be used for the synthesis of PROTACs, such as PROTACs targeting BTK (PROTACs 4 and 5) .
|
-
- HY-128805
-
|
PROTAC Linker 9
|
PROTAC Linkers
|
Cancer
|
|
Tos-PEG3-NH-Boc (PROTAC Linker 9) is a PEG-based PROTAC linker can be used in the synthesis of PROTACs .
|
-
- HY-122828
-
|
|
PROTACs
Btk
|
Others
|
|
PROTAC BTK Degrader-2 is a potent BTK PROTAC degrader. PROTAC BTK Degrader-2 effectively reduces BTK protein levels .
|
-
- HY-128833
-
|
PROTAC Linker 19
|
PROTAC Linkers
|
Cancer
|
|
Bis-NH2-PEG2 (PROTAC Linker 19) is a PEG-based PROTAC linker can be used in the synthesis of PROTACs .
|
-
- HY-119932
-
|
|
PROTACs
FAK
Akt
|
Cancer
|
|
PROTAC FAK degrader 1 (Compound PROTAC-3) is a selective and effective degrader of Fak PROTAC with a DC50 of 3.0 nM. PROTAC FAK degrader 1 reduces the ability of cancer cells to migrate and invade. PROTAC FAK degrader 1 can be used in the study of tumor. (Pink: Fak ligand (HY-44146); Black: Linker (HY-44141); Blue: VHL ligand 1 (HY-125845)) .
|
-
- HY-148813
-
|
|
PROTACs
STAT
|
Cancer
|
|
AK-2292 is a potent and selective STAT5 PROTAC degrader, with a DC50 of 0.10 μM. AK-2292 induces degradation of STAT5A/B proteins in vitro and in vivo. AK-2292 can induce tumor regression in acute myeloid leukemia and chronic myeloid leukemia xenograft mouse models . AK-2292 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
-
- HY-144624
-
|
|
PROTACs
TAM Receptor
|
Cancer
|
|
PROTAC Axl Degrader 1 is a potent and selective PROTAC Axl degrader with an IC50 of 0.92 μM. PROTAC Axl Degrader 1 shows anti-proliferation activity, anti-migration activity in vitro. PROTAC Axl Degrader 1 induces mehuosis .
|
-
- HY-144627
-
|
|
PROTACs
TAM Receptor
|
Cancer
|
|
PROTAC Axl Degrader 2 is a potent and selective PROTAC Axl degrader with an IC50 of 1.61 μM. PROTAC Axl Degrader 2 shows anti-proliferation activity, anti-migration activity in vitro. PROTAC Axl Degrader 2 induces mehuosis .
|
-
- HY-W013249
-
|
|
PROTAC Linkers
|
Cancer
|
|
Boc-piperazine-benzoic acid is a PROTAC linker and can be used in the synthesis of PROTACs, such as PROTAC androgen receptor (AR) degrader ARD-2128 (HY-13229) .
|
-
- HY-153415
-
|
|
PROTACs
Bcr-Abl
|
Cancer
|
|
PROTAC BCR-ABL Degrader-1 (compound PROTAC 1) is a PROTAC with a 2-oxoethyl linker. PROTAC BCR-ABL Degrader-1 induces Bcr-Abl degradation in a ubiquitinproteasom-dependent manner. PROTAC BCR-ABL Degrader-1 exhibits antiproliferative activity against K562 cells, and has the potential to study cancer .
|
-
- HY-W140896
-
|
|
PROTAC Linkers
|
Cancer
|
|
Dodecylheptaglycol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-159539
-
-
![COOEt-spiro[3.3]heptane-CHO](//file.medchemexpress.com/product_pic/hy-159539.gif)
- HY-126916
-
|
THP-PEG2-OH
|
PROTAC Linkers
|
Cancer
|
|
Tetrahydropyranyldiethyleneglycol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-159015
-
|
|
PROTACs
|
Cancer
|
|
SIAIS630120-NC is a negative control for NAMPT (nicotinamide phosphoribosyltransferase) degrader SIAIS630120 (Sturcture Note:(Blue: Cereblon ligand Thalidomide (HY-14658) analogue (HY-138793), Black: linker；Pink: Nampt inhibitor FK866 (HY-50876)) .
|
-
- HY-163826
-
|
|
Ligands for E3 Ligase
|
Cancer
|
|
Benzothiazole-CH2(NH-CO-CH2Cl)-CONH-CH2-Ph is a ligand for E3 ubiquitin ligase. Benzothiazole-CH2(NH-CO-CH2Cl)-CONH-CH2-Ph can be connected to the ligand for protein by a linker to form 22-SLF (HY-163807) .
|
-
- HY-161517
-
|
|
PARP
|
Cancer
|
|
PARP1-IN-20 (compound 19A10) is a potent inhibitor of PARP1, with the IC50 of 4.62 nM and has similar low PARP-Trapping effect compared with Veliparib (HY-10129), IC50 (MDA-MB-436) >100 μM .
|
-
- HY-161832
-
-
- HY-163208
-
|
(S,R,S)-AHPC-C9-NH2 hydrochloride
|
PROTAC Linkers
|
Others
|
|
VH 032 amide-alkylC9-amine hydrochloride (Linker 33) is TRK ligand conjugated to the degradation tag .
|
-
- HY-40171
-
|
PROTAC Linker 22
|
PROTAC Linkers
|
Cancer
|
|
NH2-C2-NH-Boc (PROTAC Linker 22) is a alkyl chain-based PROTAC linker can be used in the synthesis of PROTACs .
|
-
- HY-125844
-
|
PROTAC Linker 28
|
PROTAC Linkers
|
Cancer
|
|
Tos-PEG1-O-CH2COOH (PROTAC Linker 28) is a PEG-based PROTAC linker can be used in the synthesis of PROTACs .
|
-
- HY-W004710
-
|
PROTAC Linker 23
|
PROTAC Linkers
|
Cancer
|
|
NH2-C5-NH-Boc (PROTAC Linker 23) is an alkyl chain-based PROTAC linker can be used in the synthesis of PROTACs .
|
-
- HY-141233
-
|
HO-PEG12-OH
|
PROTAC Linkers
|
Cancer
|
|
Dodecaethylene glycol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-W007341
-
|
|
PROTAC Linkers
|
Cancer
|
|
Pentaethylene glycol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-130458
-
EGNHS
2 Publications Verification
EGS crosslinker
|
PROTAC Linkers
|
Cancer
|
|
EGNHS is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-141232
-
|
HO-PEG10-OH
|
PROTAC Linkers
|
Cancer
|
|
Decaethylene glycol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-141263
-
|
|
PROTAC Linkers
|
Cancer
|
|
Methyltetrazine-acid is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-W050087
-
|
|
PROTAC Linkers
|
Cancer
|
|
Octaethylene glycol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-143820
-
|
|
PROTAC Linkers
|
Cancer
|
|
Propargyl-PEG-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-141230
-
|
|
PROTAC Linkers
|
Cancer
|
|
Hexaethylene glycol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-146219
-
|
|
PROTAC Linkers
|
Others
|
|
Biotin-nPEG-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
|
-
- HY-116899
-
|
|
PROTAC Linkers
|
Cancer
|
|
Nonaethylene glycol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-141231
-
|
HO-PEG7-OH
|
PROTAC Linkers
|
Cancer
|
|
Heptaethylene glycol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-130292
-
|
|
PROTAC Linkers
|
Cancer
|
|
m-PEG-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-W096085
-
|
|
PROTAC Linkers
|
Cancer
|
|
Diethylene glycol diacetate is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-145947
-
|
|
PROTACs
|
Cancer
|
|
PROTAC BRD9 Degrader-5 is a PROTAC for targeted degradation of BRD9.
|
-
- HY-W096121
-
|
|
PROTAC Linkers
|
Cancer
|
|
PEG3 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-134751
-
|
|
PROTAC Linkers
|
Cancer
|
|
VES-POFP is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-149964
-
|
|
CDK
|
Cancer
|
|
PROTAC CDK9 degrader-7 is a PROTAC targeting to CDK9 sepcifically. PROTAC CDK9 degrader-7 mediates CDK9 degradation via the proteasome .
|
-
- HY-125888
-
|
PROTAC Linker 32
|
PROTAC Linkers
|
Cancer
|
|
Boc-NH-C6-amido-C4-acid (PROTAC Linker 32) is an alkyl ether-based PROTAC linker can be used in the synthesis of PROTACs .
|
-
- HY-159728
-
-
- HY-168017
-
-
- HY-168387
-
-
- HY-126313
-
|
PROTAC Linker 29
|
PROTAC Linkers
|
Cancer
|
|
BnOH-NH-bis-(C2-S)-propane-O-isoprene ester (PROTAC Linker 29) is an alkyl ether-based PROTAC linker can be used in the synthesis of PROTACs .
|
-
- HY-128844
-
|
PROTAC Linker 24
|
PROTAC Linkers
|
Cancer
|
|
Bis-NH2-C1-PEG3 (PROTAC Linker 24) is a PEG-based PROTAC linker can be used in the synthesis of PROTACs .
|
-
- HY-144605
-
|
|
EGFR
PROTACs
|
Cancer
|
|
PROTAC EGFR degrader 3 is a potent PROTAC EGFR degrader. PROTAC EGFR degrader 3 shows excellent cellular activity against the H1975 and HCC827 cells with high selectively. PROTAC EGFR degrader 3 shows that the lysosome is involved in the degradation process of EGFR mutant degradation .
|
-
- HY-132859
-
|
|
PROTAC Linkers
|
Cancer
|
|
Bromo-C10-OBn is a PROTAC linker that can be used in the synthesis of PROTACs.
|
-
- HY-141260
-
|
|
PROTAC Linkers
|
Cancer
|
|
Methyltetrazine-propylamine is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-119343
-
|
|
PROTAC Linkers
|
Cancer
|
|
Biotin-PFP ester is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-140338
-
|
|
PROTAC Linkers
|
Cancer
|
|
Benzenedimethanamine-diethylamine is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-143819
-
|
|
PROTAC Linkers
|
Cancer
|
|
Propargyl-PEG-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-130888
-
|
(+)-Biotin 4-nitrophenyl ester
|
PROTAC Linkers
|
Cancer
|
|
(+)-Biotin-ONP is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-124318
-
|
|
PROTAC Linkers
|
Cancer
|
|
SMPH Crosslinker is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-W067705
-
|
|
PROTAC Linkers
|
Cancer
|
|
369-Trioxaundecanedioic Acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-140341
-
|
|
PROTAC Linkers
|
Cancer
|
|
Sulfo-NHS-Acetate is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-140656A
-
|
|
PROTAC Linkers
|
Cancer
|
|
Biotin-PEG-Biotin is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-114229
-
-
- HY-134719
-
|
|
PROTAC Linkers
|
Cancer
|
|
ICG-Sulfo-OSu sodium is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-130887
-
|
|
PROTAC Linkers
|
Cancer
|
|
(+)-Biotin-SLC is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-W014831
-
|
|
PROTAC Linkers
|
Cancer
|
|
11-Aminoundecanoic acid is an alkyl chain based PROTAC linker can be used in the synthesis of PROTACs.
|
-
- HY-W019795
-
|
|
PROTAC Linkers
|
Cancer
|
|
m-PEGn-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-141175
-
|
|
PROTAC Linkers
|
Cancer
|
|
TCO-PNB ester is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-130893
-
|
|
PROTAC Linkers
|
Cancer
|
|
Biotin-EDA is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-141176
-
|
|
PROTAC Linkers
|
Cancer
|
|
TCO-amine is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-138467
-
|
|
PROTAC Linkers
|
Cancer
|
|
Mal-PFP ester is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-W004945
-
|
|
PROTAC Linkers
|
Cancer
|
|
36-Dioxaoctanedioic acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-128801
-
|
PROTAC Linker 5
|
PROTAC Linkers
|
Cancer
|
|
NH2-PEG3-C1-Boc (PROTAC Linker 5) is a PEG-based PROTAC linker can be used in the synthesis of PROTACs .
|
-
- HY-153459
-
|
|
PROTACs
Epigenetic Reader Domain
|
Cancer
|
|
PROTAC BRD4 Degrader-19 (compound 176) is a PROTAC that targets BRD4 protein for degradation. PROTAC BRD4 Degrader-19 can be used in cancer research .
|
-
- HY-W008474
-
|
PROTAC Linker 13
|
PROTAC Linkers
|
Cancer
|
|
Boc-NH-PEG2-C2-NH2 (PROTAC Linker 13) is a PEG-based PROTAC linker can be used in the synthesis of PROTACs .
|
-
- HY-130604
-
DT2216
1 Publications Verification
|
Bcl-2 Family
PROTACs
Apoptosis
|
Cancer
|
|
DT2216 is a potent and selective BCL-XL (Bcl-2 family member) degrader based on PROTAC technology. DT2216 causes effective degradation of BCL-XL protein by recruiting Von Hippel-Lindau (VHL) E3 ubiquitin ligase. DT2216 inhibits various BCL-XL-dependent leukemia and cancer cells but considerably less toxic to platelets. DT2216 is composed of the Bcl-2 family protein inhibitor Navitoclax (HY-10087), a linker, and a VHL E3 ubiquitin ligase (Red: Navitoclax; Blue: VHL ligand; Black: linker) .
|
-
- HY-122829
-
|
|
PROTACs
BCL6
|
Cancer
|
|
BCL6 PROTAC 1 is a selective B-cell lymphoma 6 (BCL6) PROTAC. BCL6 PROTAC 1 inhibits BCL6 cell reporter with an IC50 value of 8.8 µM. BCL6 PROTAC 1 significantly degrades BCL6 in diffuse large B-cell lymphoma (DLBCL) cell lines. BCL6 PROTAC 1 can be used in tumor related research .
|
-
- HY-116006
-
|
PROTAC Linker 36
|
PROTAC Linkers
|
Cancer
|
|
Bis-PEG5-acid (PROTAC Linker 36) is a PROTAC linker, which belongs to a polyethylene glycol (PEG) linker. Bis-PEG5-acid (PROTAC Linker 36) can be used in the synthesis of the CP5V. CP5V is a PROTAC, and specifically degrades Cdc20 .
|
-
- HY-W007545
-
|
PROTAC Linker 35
|
PROTAC Linkers
|
Cancer
|
|
NH2-PEG3 (PROTAC Linker 35) is a PROTAC linker, which belongs to a polyethylene glycol (PEG) linker. NH2-PEG3 (PROTAC Linker 35) can be used in the synthesis of the PROTAC (β-NF-JQ1) .
|
-
- HY-108371
-
|
PROTAC Linker 1
|
PROTAC Linkers
|
Cancer
|
|
Boc-C1-PEG2-C4-Cl (PROTAC Linker 1) is a PEG-based PROTAC linker can be used in the synthesis of PROTACs .
|
-
- HY-W022240
-
|
PROTAC Linker 17
|
PROTAC Linkers
|
Cancer
|
|
NH2-PEG5-C2-NH-Boc (PROTAC Linker 17) is a PEG-based PROTAC linker can be used in the synthesis of PROTACs .
|
-
- HY-W017440R
-
|
PROTAC Linker 25 (Standard)
|
PROTAC Linkers
|
Cancer
|
|
Triethylene glycol (Standard) is the analytical standard of Triethylene glycol. This product is intended for research and analytical applications. Triethylene glycol (PROTAC Linker 25) is a PEG-based PROTAC linker can be used in the synthesis of PROTACs .
|
-
- HY-115729
-
-
- HY-W096096
-
|
|
PROTAC Linkers
|
Cancer
|
|
Tetraethylene glycol monohexadecyl ether is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-130908
-
|
|
PROTAC Linkers
|
Cancer
|
|
11-Maleimidoundecanoic acid is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-W009787
-
|
|
PROTAC Linkers
|
Others
|
|
1-Bromo-6-chlorohexane is a PROTAC linker can be used in the synthesis of PROTACs.
|
-
- HY-22393
-
|
|
PROTAC Linkers
|
Cancer
|
|
Diethylene Glycol Monobenzyl Ether is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-W190971
-
|
|
PROTAC Linkers
|
Cancer
|
|
Triethylene glycol monodecyl ether is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-138401
-
|
|
PROTAC Linkers
|
Cancer
|
|
Dimethylamine-PEG19 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-134746
-
|
|
PROTAC Linkers
|
Cancer
|
|
Hexaethylene glycol dimethyl ether is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-130595
-
|
|
PROTAC Linkers
|
Cancer
|
|
Benzyl-PEG4-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
|
-
- HY-113336B
-
|
|
PROTAC Linkers
|
Cancer
|
|
(±)15-HETE is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-130231
-
|
|
PROTAC Linkers
|
Cancer
|
|
m-PEG2-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
|
-
- HY-120175
-
|
|
PROTAC Linkers
|
Cancer
|
|
Nonaethylene glycol monomethyl ether is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-140329
-
|
|
PROTAC Linkers
|
Cancer
|
|
6-Bromohexylphosphonic acid is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-136168
-
|
|
PROTAC Linkers
|
Cancer
|
|
Mal-amino-sulfo is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-133404
-
|
|
PROTAC Linkers
|
Cancer
|
|
Fmoc-aminooxy-PFP ester is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-W042657
-
|
|
PROTAC Linkers
|
Cancer
|
|
Octaethylene glycol monomethyl ether is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-W040195
-
|
|
PROTAC Linkers
|
Cancer
|
|
m-PEG5-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
|
-
- HY-42145
-
|
|
PROTAC Linkers
|
Cancer
|
|
3-Maleimidopropionic acid is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-W018365
-
|
|
PROTAC Linkers
|
Cancer
|
|
Tetraethylene glycol monomethyl ether is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-W044459
-
|
|
PROTAC Linkers
|
Cancer
|
|
Triethylene glycol monobenzyl ether is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-132065
-
|
PEG10-dodecyl
|
PROTAC Linkers
|
Cancer
|
|
Decaethylene glycol dodecyl ether is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-138409
-
|
|
PROTAC Linkers
|
Cancer
|
|
Dimethylamino-PEG11 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-140357
-
|
|
PROTAC Linkers
|
Cancer
|
|
Tos-PEG9 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-W096150
-
|
|
PROTAC Linkers
|
Cancer
|
|
Dimethylamino-PEG3 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-77959
-
|
|
PROTAC Linkers
|
Cancer
|
|
6-Maleimidocapronic acid is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-140991
-
|
|
PROTAC Linkers
|
Cancer
|
|
Mal-NH-Boc is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-140208
-
|
|
PROTAC Linkers
|
Cancer
|
|
22-Oxybis(ethylamine) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-141136
-
|
|
PROTAC Linkers
|
Cancer
|
|
Ac4GlcNAlk is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-W042713
-
|
|
PROTAC Linkers
|
Cancer
|
|
Pentaethylene glycol monomethyl ether is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-138310
-
|
|
PROTAC Linkers
|
Cancer
|
|
Thiol-PEG-COOH (MW 5000) is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
|
-
- HY-124531
-
|
|
PROTAC Linkers
|
Cancer
|
|
Tetra(cyanoethoxymethyl) methane is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-W142506
-
|
|
PROTAC Linkers
|
Cancer
|
|
Triethylene glycol monododecyl ether is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-130898
-
|
1,11-Bis-maleimidotetraethyleneglycol
|
PROTAC Linkers
|
Cancer
|
|
BM-PEG3 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-140328
-
|
|
PROTAC Linkers
|
Cancer
|
|
4-Bromobutylphosphonic acid is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-W037355
-
|
|
PROTAC Linkers
|
Cancer
|
|
4-Maleimidobutyric acid is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-W007853
-
|
|
PROTAC Linkers
|
Cancer
|
|
2-(Benzyloxy)ethanol is a PEG-based PROTAC linker can be used in the synthesis of PROTACs .
|
-
- HY-W018464
-
|
|
PROTAC Linkers
|
Cancer
|
|
N-Boc-serinol is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-W096158
-
|
|
PROTAC Linkers
|
Cancer
|
|
Ph-PEG3 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-W042625
-
|
|
PROTAC Linkers
|
Cancer
|
|
Hexaethylene glycol monomethyl ether is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-141268
-
|
|
PROTAC Linkers
|
Cancer
|
|
Methyltetrazine-Sulfo-NHS ester (sodium) is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-161749
-
|
|
PROTACs
Anaplastic lymphoma kinase (ALK)
|
Cancer
|
|
PROTAC ALK degrader-1 (compound B1) is an ALK degrader based on PROTACs, with the DC50 of 26 nM in H3122 EML4-ALK. PROTAC ALK degrader-1 can be used to synthesis PROTAC ALK degrader-2 (HY-161750) with superior bioavailability .
|
-
- HY-112100
-
|
|
PROTAC-Linker Conjugates for PAC
Estrogen Receptor/ERR
|
Cancer
|
|
PROTAC ERα Degrader-5 (compound LP2) consists an ADC linker and a PROTAC, whcih can be conjugated to an antibody to form PACs. PROTAC ERα Degrader-5 conjugated to an antibody is a more marked estrogen receptor-alpha (ERα) degrader compared to PROTAC (without Ab) .
|
-
- HY-128802
-
|
PROTAC Linker 6
|
PROTAC Linkers
|
Cancer
|
|
Tos-PEG3-O-C1-CH3COO (PROTAC Linker 6) is a PEG-based PROTAC linker can be used in the synthesis of PROTACs .
|
-
- HY-42776
-
|
PROTAC Linker 15
|
PROTAC Linkers
|
Cancer
|
|
NH2-PEG3-C2-NH-Boc (PROTAC Linker 15) is a PEG-based PROTAC linker can be used in the synthesis of PROTACs .
|
-
- HY-159788
-
|
|
PROTACs
Ras
|
Cancer
|
|
PROTAC K-Ras Degrader-4 (compound I-27) is a PROTAC that can effectively degrade K-Ras. PROTAC K-Ras Degrader-4 can be used in cancer research .
|
-
- HY-136001
-
|
|
PROTACs
α-synuclein
|
Neurological Disease
|
|
PROTAC α-synuclein degrader 3 (compound 5) is a potent and selective PROTAC α-synuclein degrader. PROTAC α-synuclein degrader 3 can be used in research of Parkinson's disease .
|
-
- HY-128931
-
|
PROTAC Linker 31
|
PROTAC Linkers
|
Cancer
|
|
NH2-Ph-C4-acid-NH2-Me (PROTAC Linker 31) is an alkyl chain-based PROTAC linker can be used in the synthesis of PROTACs .
|
-
- HY-128847
-
|
PROTAC Linker 26
|
PROTAC Linkers
|
Cancer
|
|
Bis-PEG1-C-PEG1-CH2COOH (PROTAC Linker 26) is a PEG-based PROTAC linker can be used in the synthesis of PROTACs .
|
-
- HY-125887
-
|
PROTAC Linker 30
|
PROTAC Linkers
|
Cancer
|
|
Boc-NH-PEG2-C2-amido-C4-acid (PROTAC Linker 30) is a PEG-based PROTAC linker can be used in the synthesis of PROTACs .
|
-
- HY-156083
-
|
|
CDK
|
Cancer
|
|
PROTAC CDK9/CycT1 Degrader-1 (compounds 10) is a potent inhibitor of CDK9. PROTAC CDK9/CycT1 Degrader-1 can be used as a PROTAC target protein ligand for PROTAC synthesis. PROTAC CDK9/CycT1 Degrader-1 shows strong anti-proliferative activity in solid tumors .
|
-
- HY-130186
-
|
|
PROTAC Linkers
|
Cancer
|
|
Methyl propionate-PEG12 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-135820
-
|
|
PROTAC Linkers
|
Cancer
|
|
m-PEG12-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-140408
-
|
|
PROTAC Linkers
|
Cancer
|
|
Bis-aminooxy-PEG2 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-140179
-
|
|
PROTAC Linkers
|
Cancer
|
|
Amino-PEG16-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-132012
-
|
|
PROTAC Linkers
|
Cancer
|
|
Benzyl-PEG9-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-147205C
-
|
|
PROTAC Linkers
|
Cancer
|
|
Biotin-PEG-OH (MW 5000) is a PEG-based PROTAC linker can be used in the synthesis of PROTAC .
|
-
- HY-141099
-
|
|
PROTAC Linkers
|
Cancer
|
|
Di(N-succinimidyl)adipate is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-133051
-
|
|
PROTAC Linkers
|
Cancer
|
|
Hydroxy-PEG5-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-140496
-
|
|
PROTAC Linkers
|
Cancer
|
|
DNP-PEG12-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-124323
-
|
|
PROTAC Linkers
|
Cancer
|
|
m-PEG4-NHS ester is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
|
-
- HY-140651
-
|
|
PROTAC Linkers
|
Cancer
|
|
Amine-PEG-thiol (MW 2000) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-140695
-
|
|
PROTAC Linkers
|
Cancer
|
|
m-PEG-Aminooxy (MW 2000) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-140642
-
|
|
PROTAC Linkers
|
Cancer
|
|
Aminooxy-PEG-OH (MW 2000) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-140652
-
|
|
PROTAC Linkers
|
Cancer
|
|
Amine-PEG-thiol (MW 3400) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-138393
-
|
|
PROTAC Linkers
|
Cancer
|
|
Benzyl-PEG6-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-140367
-
|
|
PROTAC Linkers
|
Cancer
|
|
Bis-Tos-PEG6 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-140655
-
|
|
PROTAC Linkers
|
Cancer
|
|
Biotin-PEG-amine (MW 3400) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-130425
-
|
|
PROTAC Linkers
|
Cancer
|
|
Bromo-PEG1-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs .
|
-
- HY-140549
-
|
|
PROTAC Linkers
|
Cancer
|
|
NH-bis-PEG5 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-141026
-
|
|
PROTAC Linkers
|
Cancer
|
|
Bis-PEG25-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-133386
-
|
|
PROTAC Linkers
|
Cancer
|
|
SPDP-PEG9-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-W040228
-
|
|
PROTAC Linkers
|
Cancer
|
|
BnO-PEG4-OH is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
|
-
- HY-W096116
-
|
|
PROTAC Linkers
|
Cancer
|
|
PEG2-Cl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-140548
-
|
|
PROTAC Linkers
|
Cancer
|
|
NH-bis-PEG4 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-141332
-
|
|
PROTAC Linkers
|
Cancer
|
|
Lipoamido-PEG4-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-133334
-
|
|
PROTAC Linkers
|
Cancer
|
|
Amino-PEG7-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-147205A
-
|
|
PROTAC Linkers
|
Cancer
|
|
Biotin-PEG-OH (MW 2000) is a PEG-based PROTAC linker can be used in the synthesis of PROTAC .
|
-
- HY-140657
-
|
|
PROTAC Linkers
|
Cancer
|
|
Biotin-PEG-triethoxysilane (MW 1000) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-140692
-
|
|
PROTAC Linkers
|
Cancer
|
|
m-PEG-mal (MW 20000) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-138709
-
|
|
PROTAC Linkers
|
Cancer
|
|
Benzyl-PEG6-Ots is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
|
-
- HY-141267
-
|
|
PROTAC Linkers
|
Cancer
|
|
Methyltetrazine-PEG25-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-W108220
-
|
|
PROTAC Linkers
|
Cancer
|
|
Benzyl-PEG5-Ots is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
|
-
- HY-135153
-
|
|
PROTAC Linkers
|
Cancer
|
|
Methylamino-PEG4-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-141021
-
|
|
PROTAC Linkers
|
Cancer
|
|
Bis-PEG13-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-138379
-
|
|
PROTAC Linkers
|
Cancer
|
|
Boc-PEG4-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-133054
-
|
|
PROTAC Linkers
|
Cancer
|
|
PEG4-sulfonic acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-133377
-
|
|
PROTAC Linkers
|
Cancer
|
|
Biotin-PEG24-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-141354
-
|
|
PROTAC Linkers
|
Cancer
|
|
SPDP-PEG24-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-140717
-
|
|
PROTAC Linkers
|
Cancer
|
|
HO-PEG-mal (MW 3400) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-140962
-
|
|
PROTAC Linkers
|
Cancer
|
|
Mal-PEG12-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-140334
-
|
|
PROTAC Linkers
|
Cancer
|
|
Diethyl 12-bromododecylphosphonate is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-113924
-
|
|
PROTAC Linkers
|
Cancer
|
|
Tri(t-butoxycarbonylethoxymethyl) ethanol is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-140697
-
|
mPEG-Hydroxy (MW5000); Polyethylene glycol monomethyl ether (MW5000)
|
PROTAC Linkers
|
Cancer
|
|
m-PEG-OH (MW5000) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-140183
-
|
|
PROTAC Linkers
|
Cancer
|
|
Amino-PEG25-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-120368
-
|
|
PROTAC Linkers
|
Cancer
|
|
Fluorescein-PEG4-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-141027
-
|
|
PROTAC Linkers
|
Cancer
|
|
Bis-PEG29-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-W096086
-
|
|
PROTAC Linkers
|
Cancer
|
|
Ethyl acetate-PEG1 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-133481
-
|
|
PROTAC Linkers
|
Cancer
|
|
Iodo-PEG12-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-23166
-
|
|
PROTAC Linkers
|
Cancer
|
|
Bis-PEG1-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs .
|
-
- HY-W004447
-
|
Penta(ethylene glycol) bis(p-toluenesulfonate); Bis-Tos-PEG5
|
PROTAC Linkers
|
Cancer
|
|
Pentaethylene glycol di(p-toluenesulfonate) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-133306
-
|
HO-PEG12-CH2CH2COOH
|
PROTAC Linkers
|
Cancer
|
|
Hydroxy-PEG12-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-140184
-
|
|
PROTAC Linkers
|
Cancer
|
|
Amino-PEG28-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-133308
-
|
HO-PEG16-CH2CH2COOH
|
PROTAC Linkers
|
Cancer
|
|
Hydroxy-PEG16-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-130417
-
|
|
PROTAC Linkers
|
Cancer
|
|
Tos-PEG4-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-130896
-
|
Mal-NH-PEG7-NH-Mal
|
PROTAC Linkers
|
Cancer
|
|
Bis-Mal-PEG7 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-140696
-
|
mPEG-Hydroxy (MW 2000); Polyethylene glycol monomethyl ether (MW 2000)
|
PROTAC Linkers
|
Cancer
|
|
m-PEG-OH (MW 2000) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-140674
-
|
|
PROTAC Linkers
|
Cancer
|
|
m-PEG-Butyraldehyde (MW 5000) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-140547
-
|
|
PROTAC Linkers
|
Cancer
|
|
NH-bis-PEG3 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-140709
-
|
mPEG-SH (MW 20000)
|
PROTAC Linkers
|
Cancer
|
|
m-PEG-thiol (MW 20000) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-141020
-
|
|
PROTAC Linkers
|
Cancer
|
|
Bis-PEG12-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-141334
-
|
|
PROTAC Linkers
|
Cancer
|
|
Lipoamido-PEG12-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-W096129
-
|
|
PROTAC Linkers
|
Cancer
|
|
Cl-PEG4-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-130857
-
|
|
PROTAC Linkers
|
Cancer
|
|
Mal-PEG24-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-140656D
-
|
|
PROTAC Linkers
|
Cancer
|
|
Biotin-PEG-Biotin (MW 5000) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-140703
-
|
|
PROTAC Linkers
|
Cancer
|
|
m-PEG-triethoxysilane (MW 2000) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-141022
-
|
|
PROTAC Linkers
|
Cancer
|
|
Bis-PEG14-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-130657
-
|
|
PROTAC Linkers
|
Cancer
|
|
m-PEG5-nitrile is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
|
-
- HY-43055
-
|
|
PROTAC Linkers
|
Cancer
|
|
Cl-PEG2-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-138713
-
|
|
PROTAC Linkers
|
Cancer
|
|
Benzyl-PEG10-Ots is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
|
-
- HY-W190901
-
|
|
PROTAC Linkers
|
Cancer
|
|
Amino-PEG11-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-140996
-
|
|
PROTAC Linkers
|
Cancer
|
|
Bis-Mal-PEG19 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-140716
-
|
|
PROTAC Linkers
|
Cancer
|
|
HO-PEG-amine (MW 5000) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-140411
-
|
|
PROTAC Linkers
|
Cancer
|
|
Bis-aminooxy-PEG7 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-130555
-
|
|
PROTAC Linkers
|
Cancer
|
|
PEG8-Tos is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-138487
-
|
|
PROTAC Linkers
|
Cancer
|
|
Benzyl-PEG5-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-W096089
-
|
|
PROTAC Linkers
|
Cancer
|
|
Benzyl-PEG3-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-140707
-
|
mPEG-SH (MW 5000)
|
PROTAC Linkers
|
Cancer
|
|
m-PEG-thiol (MW 5000) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-140672
-
|
|
PROTAC Linkers
|
Cancer
|
|
m-PEG-acrylate (MW 20000) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-140499
-
|
|
PROTAC Linkers
|
Cancer
|
|
m-PEG9-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-140182
-
|
|
PROTAC Linkers
|
Cancer
|
|
Amino-PEG24-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-140176
-
|
|
PROTAC Linkers
|
Cancer
|
|
Amino-PEG10-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-138311
-
|
|
PROTAC Linkers
|
Cancer
|
|
Boc-NH-PEG-Thiol (MW 10000) is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
|
-
- HY-23417
-
|
|
PROTAC Linkers
|
Cancer
|
|
PEG5-Tos is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-141264
-
|
|
PROTAC Linkers
|
Cancer
|
|
Methyltetrazine-PEG4-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-141266
-
|
|
PROTAC Linkers
|
Cancer
|
|
Methyltetrazine-PEG13-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-140641
-
|
|
PROTAC Linkers
|
Cancer
|
|
HO-PEG-amine (MW 10000) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-140953
-
|
|
PROTAC Linkers
|
Cancer
|
|
DSPE-PEG4-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-W035417
-
|
|
PROTAC Linkers
|
Cancer
|
|
Diethyl 7-bromoheptylphosphonate is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-132075
-
|
|
PROTAC Linkers
|
Cancer
|
|
Methylamino-PEG3-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-141363
-
|
|
PROTAC Linkers
|
Cancer
|
|
Bromo-PEG4-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-140656
-
|
|
PROTAC Linkers
|
Cancer
|
|
Biotin-PEG-Biotin (MW 1000) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-140673
-
|
|
PROTAC Linkers
|
Cancer
|
|
m-PEG-acrylate (MW 30000) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-140656B
-
|
|
PROTAC Linkers
|
Cancer
|
|
Biotin-PEG-Biotin (MW 2000) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-138455
-
|
|
PROTAC Linkers
|
Cancer
|
|
Bis-isopropyl-PEG1 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-42569
-
|
|
PROTAC Linkers
|
Cancer
|
|
Methyl 3-hydroxypropanoate is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-140185
-
|
|
PROTAC Linkers
|
Cancer
|
|
Amino-PEG32-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-143815
-
|
|
PROTAC Linkers
|
Cancer
|
|
m-PEG18-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-140018
-
|
|
PROTAC Linkers
|
Cancer
|
|
Thiol-PEG3-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-141019
-
|
|
PROTAC Linkers
|
Cancer
|
|
Bis-PEG11-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-141352
-
|
|
PROTAC Linkers
|
Cancer
|
|
SPDP-PEG4-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-138711
-
|
|
PROTAC Linkers
|
Cancer
|
|
Benzyl-PEG8-Ots is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
|
-
- HY-140654
-
|
|
PROTAC Linkers
|
Cancer
|
|
Biotin-PEG-amine (MW 2000) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-140721
-
|
|
PROTAC Linkers
|
Cancer
|
|
Mal-PEG-mal (MW 5000) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-140704
-
|
|
PROTAC Linkers
|
Cancer
|
|
m-PEG-triethoxysilane (MW 5000) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-140648
-
|
|
PROTAC Linkers
|
Cancer
|
|
Amine-PEG-amine (MW 5000) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-124380
-
|
|
PROTAC Linkers
|
Cancer
|
|
Hydroxy-PEG2-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-140409
-
|
|
PROTAC Linkers
|
Cancer
|
|
Bis-aminooxy-PEG3 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-138714
-
|
|
PROTAC Linkers
|
Cancer
|
|
Benzyl-PEG12-Ots is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
|
-
- HY-140700
-
|
mPEG-SC (MW 20000); mPEG-Succinimidyl ester (MW 20000)
|
PROTAC Linkers
|
Cancer
|
|
m-PEG-NHS ester (MW 20000) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-140332
-
|
|
PROTAC Linkers
|
Cancer
|
|
Diethyl 8-bromooctylphosphonate is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-140693
-
|
|
PROTAC Linkers
|
Cancer
|
|
m-PEG-mal (MW 30000) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-140638
-
|
|
PROTAC Linkers
|
Cancer
|
|
Acrylate-PEG-OH (MW 3400) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-140161
-
|
|
PROTAC Linkers
|
Cancer
|
|
PEG3-methylamine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-140407
-
|
|
PROTAC Linkers
|
Cancer
|
|
Bis-aminooxy-PEG1 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-130542
-
|
|
PROTAC Linkers
|
Cancer
|
|
Thiol-PEG8-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-140653
-
|
|
PROTAC Linkers
|
Cancer
|
|
Amine-PEG-thiol (MW 5000) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-130904
-
|
|
PROTAC Linkers
|
Cancer
|
|
DSPE-PEG47-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-140153
-
|
|
PROTAC Linkers
|
Cancer
|
|
Methylamino-PEG2-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-140723
-
|
|
PROTAC Linkers
|
Cancer
|
|
Carboxymethyl-PEG-Carboxymethyl (MW 5000) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-133052
-
|
|
PROTAC Linkers
|
Cancer
|
|
Hydroxy-PEG3-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-138710
-
|
|
PROTAC Linkers
|
Cancer
|
|
Benzyl-PEG7-Ots is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
|
-
- HY-141023
-
|
|
PROTAC Linkers
|
Cancer
|
|
Bis-PEG15-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-W010948
-
|
Diethylene glycol di(p-toluenesulfonate); Bis-Tos-PEG2
|
PROTAC Linkers
|
Cancer
|
|
Diethylene glycol bis(p-toluenesulfonate) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-140713
-
|
|
PROTAC Linkers
|
Cancer
|
|
HO-PEG-amine (MW 1000) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-141393
-
|
|
PROTAC Linkers
|
Cancer
|
|
Bis-Bromoacetamido-PEG11 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-140994
-
|
|
PROTAC Linkers
|
Cancer
|
|
Bis-Mal-PEG6 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-W013731
-
|
Bis-Tos-PEG3
|
PROTAC Linkers
|
Cancer
|
|
Triethylene glycol bis(p-toluenesulfonate) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-140388
-
|
|
PROTAC Linkers
|
Cancer
|
|
PEG4-MS is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-140178
-
|
|
PROTAC Linkers
|
Cancer
|
|
Amino-PEG14-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-140659
-
|
|
PROTAC Linkers
|
Cancer
|
|
Biotin-PEG-triethoxysilane (MW 5000) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-138524
-
|
|
PROTAC Linkers
|
Cancer
|
|
Thiol-PEG2-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-140495
-
|
|
PROTAC Linkers
|
Cancer
|
|
DNP-PEG6-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-141024
-
|
|
PROTAC Linkers
|
Cancer
|
|
Bis-PEG17-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-141383
-
|
|
PROTAC Linkers
|
Cancer
|
|
Bromoacetamido-PEG8-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-133385
-
|
|
PROTAC Linkers
|
Cancer
|
|
SPDP-PEG7-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-140177
-
|
|
PROTAC Linkers
|
Cancer
|
|
Amino-PEG12-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-140735
-
|
|
PROTAC Linkers
|
Cancer
|
|
DSPE-PEG-Amine, MW 5000 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-140640
-
|
|
PROTAC Linkers
|
Cancer
|
|
Acrylate-PEG-OH (MW 10000) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-140718
-
|
|
PROTAC Linkers
|
Cancer
|
|
HO-PEG-mal (MW 5000) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-133384
-
|
|
PROTAC Linkers
|
Cancer
|
|
SPDP-PEG5-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-141326
-
|
|
PROTAC Linkers
|
Cancer
|
|
Thiol-PEG12-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-133064
-
|
|
PROTAC Linkers
|
Cancer
|
|
m-PEG3-NHS ester is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
|
-
- HY-140394
-
|
|
PROTAC Linkers
|
Cancer
|
|
Aminooxy-PEG4-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-140720
-
|
|
PROTAC Linkers
|
Cancer
|
|
Mal-PEG-mal (MW 3400) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-140410
-
|
|
PROTAC Linkers
|
Cancer
|
|
Bis-aminooxy-PEG4 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-140186
-
|
|
PROTAC Linkers
|
Cancer
|
|
Amino-PEG36-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-140929
-
|
|
PROTAC Linkers
|
Cancer
|
|
Bis-Biotin-PEG23 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-122413
-
|
|
PROTAC Linkers
|
Cancer
|
|
m-PEG7-NHS ester is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
|
-
- HY-133425
-
|
|
PROTAC Linkers
|
Cancer
|
|
2-Phthalimidehydroxy-acetic acid is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-W190962
-
|
|
PROTAC Linkers
|
Cancer
|
|
BocNH-PEG5-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-141164
-
|
|
PROTAC Linkers
|
Cancer
|
|
TCO-PEG36-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-130198
-
|
|
PROTAC Linkers
|
Cancer
|
|
DNP-PEG4-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-140494
-
|
|
PROTAC Linkers
|
Cancer
|
|
Biotin-PEG36-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-132027
-
|
|
PROTAC Linkers
|
Cancer
|
|
Benzyl-PEG7-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-140995
-
|
|
PROTAC Linkers
|
Cancer
|
|
Bis-Mal-PEG11 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-140333
-
|
|
PROTAC Linkers
|
Cancer
|
|
Diethyl 10-bromodecylphosphonate is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-140708
-
|
mPEG-SH (MW 10000)
|
PROTAC Linkers
|
Cancer
|
|
m-PEG-thiol (MW 10000) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-140734
-
|
|
PROTAC Linkers
|
Cancer
|
|
DSPE-PEG-Amine, MW 3400 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-133290
-
|
HS-PEG5-CH2CH2COOH
|
PROTAC Linkers
|
Cancer
|
|
Thiol-PEG5-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-133324
-
|
|
PROTAC Linkers
|
Cancer
|
|
m-PEG37-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-132015
-
|
|
PROTAC Linkers
|
Cancer
|
|
Benzyl-PEG8-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-133323
-
|
|
PROTAC Linkers
|
Cancer
|
|
m-PEG24-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-140502
-
|
|
PROTAC Linkers
|
Cancer
|
|
m-PEG17-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-120678
-
|
|
PROTAC Linkers
|
Others
|
|
DBCO-PEG4-acid is a a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-140639
-
|
|
PROTAC Linkers
|
Cancer
|
|
Acrylate-PEG-OH (MW 5000) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-141333
-
|
|
PROTAC Linkers
|
Cancer
|
|
Lipoamido-PEG8-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-140694
-
|
|
PROTAC Linkers
|
Cancer
|
|
m-PEG-NPC (MW 20000) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-140705
-
|
|
PROTAC Linkers
|
Cancer
|
|
m-PEG-Tos (MW 2000) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-136159
-
|
|
PROTAC Linkers
|
Cancer
|
|
3-Mercaptopropanyl-N-hydroxysuccinimide ester is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-138486
-
|
|
PROTAC Linkers
|
Cancer
|
|
Br-PEG4-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-140699
-
|
mPEG-SC (MW 10000); mPEG-Succinimidyl ester (MW 10000)
|
PROTAC Linkers
|
Cancer
|
|
m-PEG-NHS ester (MW 10000) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-140702
-
|
|
PROTAC Linkers
|
Cancer
|
|
m-PEG-triethoxysilane (MW 1000) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-130938
-
|
|
PROTAC Linkers
|
Cancer
|
|
m-PEG25-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-140358
-
|
|
PROTAC Linkers
|
Cancer
|
|
PEG20-Tos is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-140330
-
|
|
PROTAC Linkers
|
Cancer
|
|
(10-BRomodecyl)phosphonic acid is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-140724
-
|
|
PROTAC Linkers
|
Cancer
|
|
Bis-PEG-TFP ester (MW 5000) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-130895
-
|
|
PROTAC Linkers
|
Cancer
|
|
Bis-Mal-PEG5 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-141335
-
|
|
PROTAC Linkers
|
Cancer
|
|
Lipoamido-PEG24-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-W108219
-
|
|
PROTAC Linkers
|
Cancer
|
|
Benzyl-PEG4-Ots is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
|
-
- HY-132088
-
|
|
PROTAC Linkers
|
Cancer
|
|
N-Boc-PEG-t-butyl ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-140368
-
|
|
PROTAC Linkers
|
Cancer
|
|
Bis-Tos-PEG7 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-W096147
-
|
|
PROTAC Linkers
|
Cancer
|
|
S-acetyl-PEG6 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-W042714
-
|
|
PROTAC Linkers
|
Cancer
|
|
BnO-PEG5-OH is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
|
-
- HY-140656C
-
|
|
PROTAC Linkers
|
Cancer
|
|
Biotin-PEG-Biotin (MW 3400) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-140710
-
|
|
PROTAC Linkers
|
Cancer
|
|
m-PEG-Tresyl (MW 5000) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-140691
-
|
|
PROTAC Linkers
|
Cancer
|
|
m-PEG-mal (MW 10000) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-140180
-
|
|
PROTAC Linkers
|
Cancer
|
|
Amino-PEG20-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-140993
-
|
|
PROTAC Linkers
|
Cancer
|
|
Bis-Mal-PEG3 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-W096166
-
|
|
PROTAC Linkers
|
Cancer
|
|
Bis-acrylate-PEG6 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-140706
-
|
mPEG-SH (MW 2000)
|
PROTAC Linkers
|
Cancer
|
|
m-PEG-thiol (MW 2000) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-W096131
-
|
|
PROTAC Linkers
|
Cancer
|
|
Chloro-PEG5-chloride is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-140698
-
|
mPEG-SC (MW 5000); mPEG-Succinimidyl ester (MW 5000)
|
PROTAC Linkers
|
Cancer
|
|
m-PEG-NHS ester (MW 5000) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-140395
-
|
|
PROTAC Linkers
|
Cancer
|
|
Aminooxy-PEG8-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-133322
-
|
|
PROTAC Linkers
|
Cancer
|
|
m-PEG21-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-141265
-
|
|
PROTAC Linkers
|
Cancer
|
|
Methyltetrazine-PEG8-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-140656E
-
|
|
PROTAC Linkers
|
Cancer
|
|
Biotin-PEG-Biotin (MW 10000) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-140650
-
|
|
PROTAC Linkers
|
Cancer
|
|
Amine-PEG-amine (MW 35000) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-141025
-
|
|
PROTAC Linkers
|
Cancer
|
|
Bis-PEG21-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-W096155
-
|
|
PROTAC Linkers
|
Cancer
|
|
Methyl acetate-PEG1 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-140715
-
|
|
PROTAC Linkers
|
Cancer
|
|
HO-PEG-amine (MW 3400) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-140670
-
|
|
PROTAC Linkers
|
Cancer
|
|
m-PEG-acrylate (MW 2000) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-130446
-
|
|
PROTAC Linkers
|
Cancer
|
|
m-PEG9-NHS ester is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
|
-
- HY-138507
-
|
|
PROTAC Linkers
|
Cancer
|
|
Desthiobiotin-PEG4-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-133231
-
|
|
PROTAC Linkers
|
Cancer
|
|
Bis-PEG10-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs .
|
-
- HY-141163
-
|
|
PROTAC Linkers
|
Cancer
|
|
TCO-PEG24-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-140000
-
|
|
PROTAC Linkers
|
Cancer
|
|
Methylamino-PEG1-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-147205
-
|
|
PROTAC Linkers
|
Others
|
|
Biotin-PEG-OH (MW 1000) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-140005
-
|
|
PROTAC Linkers
|
Cancer
|
|
Aminooxy-PEG3-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-130213
-
|
|
PROTAC Linkers
|
Cancer
|
|
Thiol-PEG4-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-138436
-
|
|
PROTAC Linkers
|
Cancer
|
|
PEG2-ethyl acetate is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-140181
-
|
|
PROTAC Linkers
|
Cancer
|
|
Amino-PEG23-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-133291
-
|
|
PROTAC Linkers
|
Cancer
|
|
Thiol-PEG6-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-140658
-
|
|
PROTAC Linkers
|
Cancer
|
|
Biotin-PEG-triethoxysilane (MW 2000) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-140421
-
|
|
PROTAC Linkers
|
Cancer
|
|
Boc-Aminooxy-PEG2 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-138411
-
|
|
PROTAC Linkers
|
Cancer
|
|
Cl-PEG6-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-140736
-
|
DSPE-PEG(2000) Biotin
|
Liposome
PROTAC Linkers
|
Cancer
|
|
DSPE-PEG-Biotin, MW 2000 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-147205D
-
|
|
PROTAC Linkers
|
Cancer
|
|
Biotin-PEG-OH (MW 10000) is a PEG-based PROTAC linker can be used in the synthesis of PROTAC .
|
-
- HY-W096160
-
|
|
PROTAC Linkers
|
Cancer
|
|
Bis-acrylate-PEG5 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-140714
-
|
|
PROTAC Linkers
|
Cancer
|
|
HO-PEG-amine (MW 2000) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-138723
-
|
|
PROTAC Linkers
|
Cancer
|
|
Mal-PEG10-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-138505
-
|
|
PROTAC Linkers
|
Cancer
|
|
Iodoacetamido-PEG6-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-140671
-
|
|
PROTAC Linkers
|
Cancer
|
|
m-PEG-acrylate (MW 10000) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-140719
-
|
|
PROTAC Linkers
|
Cancer
|
|
Mal-PEG-mal (MW 2000) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-133325
-
|
|
PROTAC Linkers
|
Cancer
|
|
m-PEG49-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-W096142
-
|
|
PROTAC Linkers
|
Cancer
|
|
Benzyl-PEG2-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-133065
-
|
|
PROTAC Linkers
|
Cancer
|
|
m-PEG5-NHS ester is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
|
-
- HY-W096161
-
|
|
PROTAC Linkers
|
Cancer
|
|
Bis-methacrylate-PEG5 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-134754
-
|
|
PROTAC Linkers
|
Cancer
|
|
Bromo-PEG12-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-140689
-
|
|
PROTAC Linkers
|
Cancer
|
|
m-PEG-mal (MW 2000) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-76043
-
|
|
ADC Linker
PROTAC Linkers
|
Cancer
|
|
H-Hyp-OMe hydrochloride is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). H-Hyp-OMe hydrochloride is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1]<
|
-
- HY-168018
-
|
|
Ligands for Target Protein for PROTAC
|
Cancer
|
|
Demethyl-NSC682769 is a PROTAC target protein ligand (Ligands for Target Protein for PROTACs). Demethyl-NSC682769 can be used in synthesis PROTAC YAP degrader-1 (HY-168016) .
|
-
- HY-I0781
-
|
|
ADC Linker
PROTAC Linkers
|
Cancer
|
|
Boc-Hyp-OH is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Boc-Hyp-OH is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[2]
|
-
- HY-159538
-
|
|
PROTAC Linkers
|
Cancer
|
|
PROTAC SMARCA2 degrader-6-Linker is a PROTAC linker that connects the E3 ligase ligand and the SMARCA2 ligand to form PROTAC SMARCA2 degrader-6 (HY-159448).
|
-
![COOEt-bicyclo[2.2.2]octane-CHO](//file.medchemexpress.com/product_pic/hy-159538.gif)
- HY-W018154
-
|
|
ADC Linker
PROTAC Linkers
|
Cancer
|
|
H-Glu-OtBu is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). H-Glu-OtBu is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[2
|
-
- HY-159615
-
-
- HY-153901
-
|
|
EGFR
PROTACs
|
Cancer
|
|
PROTAC EGFR degrader 8 (T-184) is a PROTAC EGFR degrader. PROTAC EGFR degrader 8 degrades EGFR in HCC827 cell with a DC50 of 15.56 nM. PROTAC EGFR degrader 8 inhibits H1975, PC-9, HCC827 cell growth with IC50s of 7.72 nM, 121.9 nM, 14.21 nM. PROTAC EGFR degrader 8 can be used for research of cancer, especially NSCLC .
|
-
- HY-153864
-
|
|
PROTACs
MEK
ERK
|
Cancer
|
|
PROTAC MEK1 Degrader-1 is a PROTAC targeting MEK1 with a pIC50 value of 7.0. PROTAC MEK1 Degrader-1 consists of a MEK1 inhibitor and a von Hippel-Lindau ligand. PROTAC MEK1 Degrader-1 can inhibit ERK1/2 phosphorylation. PROTAC MEK1 Degrader-1 shows an antiproliferative activity against A375 cells .
|
-
- HY-168518
-
|
|
PROTACs
CDK
|
Cancer
|
|
PROTAC CDK9 degrader-9 (compound 29) is a highly selective and efficient CDK9 degrader based on PROTAC technology. PROTAC CDK9 degrader-9 can be used in anti-cancer research .
|
-
- HY-161280
-
|
|
PROTACs
FLT3
|
Cancer
|
|
PROTAC FLT-3 degrader 3 (compound 35) is a PROTACs degrader of FLT. PROTAC FLT-3 degrader 3 has antiproliferative activity, with IC50 of 7.55 nM in MV4-11 cells .
|
-
- HY-162544
-
|
|
PROTACs
MAP4K
|
Cancer
|
|
PROTAC HPK1 Degrader-2 (compound 3) is a PROTAC degrader of HPK1, with the DC50 of 23 nM in human PBMC. PROTAC HPK1 Degrader-2 plays an important role in cancer research .
|
-
- HY-149870
-
|
|
PROTACs
CDK
|
Cancer
|
|
PROTAC CDK9 degrader-8 (compound 21) is a potent PROTAC CDK9 degrader with an IC50 value of 0.01 μM. PROTAC CDK9 degrader-8 can be used in research of cancer .
|
-
- HY-120430
-
|
|
PROTAC Linkers
|
Cancer
|
|
HO-PEG14-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-140722
-
|
|
PROTAC Linkers
|
Cancer
|
|
Mal-PEG-Succinimidyl Valerate (MW 20000) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-133493
-
|
|
PROTAC Linkers
|
Cancer
|
|
Folate-PEG3-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-140516
-
|
|
PROTAC Linkers
|
Cancer
|
|
NH-bis(PEG4-acid) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-141368
-
|
|
PROTAC Linkers
|
Cancer
|
|
Bromo-PEG8-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-133279
-
|
|
PROTAC Linkers
|
Cancer
|
|
m-PEG11-Br is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-138354
-
|
|
PROTAC Linkers
|
Cancer
|
|
Pyrroline-5-carboxylate is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-134710
-
|
|
PROTAC Linkers
|
Cancer
|
|
Benzyl-PEG24-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-133354
-
|
|
PROTAC Linkers
|
Cancer
|
|
Mal-PEG11-mal is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-140387
-
|
|
PROTAC Linkers
|
Cancer
|
|
Ms-PEG12-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-140156
-
|
Methylamino-PEG4-t-butyl ester
|
PROTAC Linkers
|
Cancer
|
|
Methylamino-PEG4-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-133345
-
|
|
PROTAC Linkers
|
Cancer
|
|
m-PEG7-Hydrazide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-143844
-
|
|
PROTAC Linkers
|
Cancer
|
|
Bromo-PEG7-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-140984
-
|
|
PROTAC Linkers
|
Cancer
|
|
m-PEG24-Mal is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-130534
-
|
|
PROTAC Linkers
|
Cancer
|
|
Tos-PEG2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-140162
-
|
|
PROTAC Linkers
|
Cancer
|
|
Hydroxy-PEG4-methylamine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-140197
-
|
|
PROTAC Linkers
|
Cancer
|
|
Amino-PEG12-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-132097
-
|
|
PROTAC Linkers
|
Cancer
|
|
Bromo-PEG4-PFP ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-135142
-
|
|
PROTAC Linkers
|
Cancer
|
|
Br-PEG3-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-134752
-
|
|
PROTAC Linkers
|
Cancer
|
|
Benzyl-PEG9-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-140933
-
|
|
PROTAC Linkers
|
Cancer
|
|
Biotin-PEG12-hydrazide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-141174
-
|
|
PROTAC Linkers
|
Cancer
|
|
TCO-PEG12-TFP ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-138352
-
|
|
PROTAC Linkers
|
Cancer
|
|
THP-PEG4-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-120724
-
|
|
PROTAC Linkers
|
Cancer
|
|
HO-PEG15-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-132052
-
|
|
PROTAC Linkers
|
Cancer
|
|
Benzyl-PEG12-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-140957
-
|
|
PROTAC Linkers
|
Cancer
|
|
Mal-PEG12-DSPE is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-138385
-
|
|
PROTAC Linkers
|
Cancer
|
|
MS-PEG5-THP is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-141298
-
|
|
PROTAC Linkers
|
Cancer
|
|
Bromo-PEG5-phosphonic acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-141367
-
|
|
PROTAC Linkers
|
Cancer
|
|
Bromo-PEG6-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-141302
-
|
|
PROTAC Linkers
|
Cancer
|
|
Carboxy-PEG4-phosphonic acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-134698
-
|
|
PROTAC Linkers
|
Cancer
|
|
THP-PEG9-THP is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-140365
-
|
|
PROTAC Linkers
|
Cancer
|
|
Tos-PEG13-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-138449
-
|
|
PROTAC Linkers
|
Cancer
|
|
m-PEG6-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-138513
-
|
|
PROTAC Linkers
|
Cancer
|
|
Benzyl-PEG4-acyl chloride is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-133327
-
|
H2N-PEG12-CH2CH2NH2
|
PROTAC Linkers
|
Cancer
|
|
Amino-PEG12-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-130600
-
|
|
PROTAC Linkers
|
Cancer
|
|
HO-PEG17-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-140615
-
|
|
PROTAC Linkers
|
Cancer
|
|
DNP-PEG12-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-138347
-
|
|
PROTAC Linkers
|
Cancer
|
|
THP-PEG10-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-138324
-
|
|
PROTAC Linkers
|
Cancer
|
|
Ms-PEG6-MS is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-W096069
-
|
|
PROTAC Linkers
|
Cancer
|
|
Hydroxy-PEG3-MS is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-130834
-
|
|
PROTAC Linkers
|
Cancer
|
|
Hydroxy-PEG24-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-134711
-
|
|
PROTAC Linkers
|
Cancer
|
|
Amine-PEG6-thiol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-138428
-
|
|
PROTAC Linkers
|
Cancer
|
|
m-PEG9-Mal is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-140618
-
|
|
PROTAC Linkers
|
Cancer
|
|
DNP-PEG4-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-133495
-
|
|
PROTAC Linkers
|
Cancer
|
|
Folate-PEG2-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-126919
-
|
|
PROTAC Linkers
|
Cancer
|
|
THP-PEG8-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-132070
-
|
Folic acid-PEG5-Mal
|
PROTAC Linkers
|
Cancer
|
|
FA-PEG5-Mal is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-141258
-
|
|
PROTAC Linkers
|
Cancer
|
|
Bis-PEG25-TFP ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-130830
-
|
|
PROTAC Linkers
|
Cancer
|
|
m-PEG24-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-132095
-
|
|
PROTAC Linkers
|
Cancer
|
|
Methyl-PEG4-acyl chloride is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-138515
-
|
|
PROTAC Linkers
|
Cancer
|
|
Br-PEG7-NHBoc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-140965
-
|
|
PROTAC Linkers
|
Cancer
|
|
Mal-PEG5-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-133278
-
|
|
PROTAC Linkers
|
Cancer
|
|
m-PEG10-Br is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-132053
-
|
|
PROTAC Linkers
|
Cancer
|
|
Benzyl-PEG16-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-103628
-
|
|
PROTACs
CDK
|
Cancer
|
|
PROTAC CDK9 Degrader-1 is a PROTAC connected by ligands for Cereblon and CDK as a selective CDK9 degrader.
|
-
- HY-140963
-
|
|
PROTAC Linkers
|
Cancer
|
|
Mal-PEG12-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-140742
-
|
|
PROTAC Linkers
|
Cancer
|
|
Benzyl-PEG2-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-138382
-
|
|
PROTAC Linkers
|
Cancer
|
|
m-PEG4-PFP ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-140975
-
|
|
PROTAC Linkers
|
Cancer
|
|
Mal-amido-PEG24-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-133494
-
|
|
PROTAC Linkers
|
Cancer
|
|
Folate-PEG1-mal is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-132014
-
|
|
PROTAC Linkers
|
Cancer
|
|
THP-PEG11-THP is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-140362
-
|
|
PROTAC Linkers
|
Cancer
|
|
m-PEG2-MS is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-141109
-
|
|
PROTAC Linkers
|
Cancer
|
|
m-PEG25-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-143827
-
|
|
PROTAC Linkers
|
Cancer
|
|
Biotin-PEG10-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-138490
-
|
|
PROTAC Linkers
|
Cancer
|
|
Iodoacetyl-PEG8-biotin is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-140396
-
|
|
PROTAC Linkers
|
Cancer
|
|
Aminooxy-PEG3-bromide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-W007529
-
|
|
PROTAC Linkers
|
Cancer
|
|
Boc-6-aminohexanoic acid is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-141337
-
|
|
PROTAC Linkers
|
Cancer
|
|
Lipoamido-PEG2-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-140601
-
|
|
PROTAC Linkers
|
Cancer
|
|
Sulfone-Bis-PEG4-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-140165
-
|
|
PROTAC Linkers
|
Cancer
|
|
Bis-PEG3-sulfonic acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-140206
-
|
|
PROTAC Linkers
|
Cancer
|
|
Amino-PEG24-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-133300
-
|
|
PROTAC Linkers
|
Cancer
|
|
HO-PEG22-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-133289
-
|
|
PROTAC Linkers
|
Cancer
|
|
m-PEG48-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-W096073
-
|
|
PROTAC Linkers
|
Cancer
|
|
Benzyl-PEG4-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-141357
-
|
|
PROTAC Linkers
|
Cancer
|
|
SPDP-PEG24-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-140973
-
|
|
PROTAC Linkers
|
Cancer
|
|
Mal-amido-PEG10-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-141272
-
|
|
PROTAC Linkers
|
Cancer
|
|
Methyltetrazine-PEG24-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-135169
-
|
|
PROTAC Linkers
|
Cancer
|
|
Mal-PEG3-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-138482
-
|
|
PROTAC Linkers
|
Cancer
|
|
MS-PEG1-THP is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-141394
-
|
|
PROTAC Linkers
|
Cancer
|
|
Chloroacetamido-PEG4-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-133344
-
|
|
PROTAC Linkers
|
Cancer
|
|
m-PEG3-Hydrazide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-W096075
-
|
|
PROTAC Linkers
|
Cancer
|
|
Benzyl-PEG5-THP is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-141271
-
|
|
PROTAC Linkers
|
Cancer
|
|
Methyltetrazine-PEG13-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-141106
-
|
|
PROTAC Linkers
|
Cancer
|
|
m-PEG12-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-141269
-
|
|
PROTAC Linkers
|
Cancer
|
|
Methyltetrazine-PEG5-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-141369
-
|
|
PROTAC Linkers
|
Cancer
|
|
Bromo-PEG24-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-140971
-
|
|
PROTAC Linkers
|
Cancer
|
|
Mal-PEG12-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-140399
-
|
|
PROTAC Linkers
|
Cancer
|
|
Aminooxy-PEG7-methane is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-130336
-
|
|
PROTAC Linkers
|
Cancer
|
|
m-PEG6-Tos is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-138722
-
|
|
PROTAC Linkers
|
Cancer
|
|
Mal-PEG10-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-130469
-
|
|
PROTAC Linkers
|
Cancer
|
|
Mal-PEG4-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-141206
-
|
|
PROTAC Linkers
|
Cancer
|
|
Hydroxy-PEG11-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-141366
-
|
|
PROTAC Linkers
|
Cancer
|
|
Bromo-PEG5-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-133299
-
|
|
PROTAC Linkers
|
Cancer
|
|
Br-PEG7-Br is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-130672
-
|
|
PROTAC Linkers
|
Cancer
|
|
Hydroxy-PEG3-NHS is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-W096081
-
|
|
PROTAC Linkers
|
Cancer
|
|
Benzyl-PEG10-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-132068
-
|
|
PROTAC Linkers
|
Cancer
|
|
THP-PEG7-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-130890
-
|
|
PROTAC Linkers
|
Cancer
|
|
(+)-Biotin-PEG12-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-133298
-
|
H2N-PEG14-OH
|
PROTAC Linkers
|
Cancer
|
|
Amino-PEG14-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-138342
-
|
|
PROTAC Linkers
|
Cancer
|
|
Benzyl-PEG1-MS is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-138337
-
|
|
PROTAC Linkers
|
Cancer
|
|
MS-PEG8-THP is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-W096072
-
|
|
PROTAC Linkers
|
Cancer
|
|
Benzyl-PEG2-MS is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-140620
-
|
|
PROTAC Linkers
|
Cancer
|
|
m-PEG4-aldehyde is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-133294
-
|
HS-PEG8-OH
|
PROTAC Linkers
|
Cancer
|
|
Thiol-PEG8-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-134697
-
|
|
PROTAC Linkers
|
Cancer
|
|
Benzyl-PEG15-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-141373
-
|
|
PROTAC Linkers
|
Cancer
|
|
Bromo-PEG3-bromide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-138477
-
|
|
PROTAC Linkers
|
Cancer
|
|
Benzyl-PEG24-THP is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-141100
-
|
|
PROTAC Linkers
|
Cancer
|
|
Bis-PEG11-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-130512
-
|
|
PROTAC Linkers
|
Cancer
|
|
Br-PEG4-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-138424
-
|
|
PROTAC Linkers
|
Cancer
|
|
m-PEG15-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-133383
-
|
|
PROTAC Linkers
|
Cancer
|
|
DSPE-PEG46-Folate is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-135940
-
|
|
PROTAC Linkers
|
Cancer
|
|
m-PEG3-Mal is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-141255
-
|
|
PROTAC Linkers
|
Cancer
|
|
Bis-PEG9-PFP ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-135819
-
|
|
PROTAC Linkers
|
Cancer
|
|
Mal-PEG24-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-132021
-
|
|
PROTAC Linkers
|
Cancer
|
|
Benzyl-PEG7-NHBoc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-140171
-
|
|
PROTAC Linkers
|
Cancer
|
|
m-PEG5-sulfonic acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-143855
-
|
|
PROTAC Linkers
|
Cancer
|
|
Biotin-PEG10-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-141093
-
|
|
PROTAC Linkers
|
Cancer
|
|
Pyrene-PEG5-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-141217
-
|
O-Methyl-heptaethylene glycol
|
PROTAC Linkers
|
Cancer
|
|
m-PEG7-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-133352
-
|
|
PROTAC Linkers
|
Cancer
|
|
Mal-PEG5-mal is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-W040527
-
|
|
PROTAC Linkers
|
Cancer
|
|
Bromo-PEG4-bromide is a PEG-based PROTAC linker can be used in the synthesis of PROTACs .
|
-
- HY-W096157
-
|
|
PROTAC Linkers
|
Cancer
|
|
I-PEG5-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-141236
-
|
|
PROTAC Linkers
|
Cancer
|
|
HO-PEG20-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-140951
-
|
|
PROTAC Linkers
|
Cancer
|
|
m-PEG12-DSPE is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-140440
-
|
|
PROTAC Linkers
|
Cancer
|
|
Fmoc-aminooxy-PEG4-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-W096153
-
|
|
PROTAC Linkers
|
Cancer
|
|
m-PEG3-phosphonic acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-138346
-
|
|
PROTAC Linkers
|
Cancer
|
|
Benzyl-PEG4-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-138483
-
|
|
PROTAC Linkers
|
Cancer
|
|
THP-PEG9-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-133378
-
|
|
PROTAC Linkers
|
Cancer
|
|
Biotin-PEG24-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-141282
-
|
|
PROTAC Linkers
|
Cancer
|
|
Methyltetrazine-PEG24-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-132104
-
|
|
PROTAC Linkers
|
Cancer
|
|
THP-PEG12-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-134700
-
|
|
PROTAC Linkers
|
Cancer
|
|
DSPE-PEG14-COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-134720
-
|
|
PROTAC Linkers
|
Cancer
|
|
Amine-PEG4-Desthiobiotin is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-133351
-
|
|
PROTAC Linkers
|
Cancer
|
|
m-PEG25-Hydrazide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-132048
-
|
|
PROTAC Linkers
|
Cancer
|
|
Benzyl-PEG7-MS is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-130342
-
|
|
PROTAC Linkers
|
Cancer
|
|
HO-PEG11-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-140751
-
|
|
PROTAC Linkers
|
Cancer
|
|
Benzyl-PEG5-MS is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-140989
-
|
|
PROTAC Linkers
|
Cancer
|
|
Mal-PEG1-bromide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-140909
-
|
|
PROTAC Linkers
|
Cancer
|
|
Biotin-PEG11-Mal is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-141101
-
|
|
PROTAC Linkers
|
Cancer
|
|
Fmoc-PEG12-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-135941
-
|
|
PROTAC Linkers
|
Cancer
|
|
Biotin-PEG9-NHS Ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-138323
-
|
|
PROTAC Linkers
|
Cancer
|
|
Benzyl-PEG36-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-140008
-
|
|
PROTAC Linkers
|
Cancer
|
|
DOTA-PEG5-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-140733
-
|
(1,3-dioxoisoindolin-2-yl)-O-PEG-OMe (MW 2000)
|
PROTAC Linkers
|
Cancer
|
|
Dioxoisoindolin-O-PEG-OMe (MW 2000) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-138468
-
|
|
PROTAC Linkers
|
Cancer
|
|
Boc-PEG25-benzyl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-140983
-
|
|
PROTAC Linkers
|
Cancer
|
|
m-PEG12-Mal is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-130152
-
|
|
PROTAC Linkers
|
Cancer
|
|
Ms-PEG7-MS is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-133295
-
|
HS-PEG10-OH
|
PROTAC Linkers
|
Cancer
|
|
Thiol-PEG10-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-133329
-
|
H2N-PEG15-CH2CH2NH2
|
PROTAC Linkers
|
Cancer
|
|
Amino-PEG15-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-138395
-
|
|
PROTAC Linkers
|
Cancer
|
|
DSPE-PEG6-Mal is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-144081
-
|
|
PROTAC Linkers
|
Cancer
|
|
HO-PEG18-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-W840791
-
|
|
PROTAC Linkers
|
Cancer
|
|
1-(2-Bromoethyl)piperazine is a PROTAC linker can be used in the synthesis of PROTAC (HY-168634) .
|
-
- HY-140904
-
|
|
PROTAC Linkers
|
Cancer
|
|
Biotin-PEG12-TFP ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-W096077
-
|
|
PROTAC Linkers
|
Cancer
|
|
Benzyl-PEG7-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-140240
-
-
- HY-126717
-
|
|
PROTAC Linkers
|
Cancer
|
|
SPDP-PEG6-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-140263
-
|
|
PROTAC Linkers
|
Cancer
|
|
NH-bis(m-PEG4) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-141238
-
|
|
PROTAC Linkers
|
Cancer
|
|
HO-PEG24-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-132013
-
|
|
PROTAC Linkers
|
Cancer
|
|
Benzyl-PEG8-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-140200
-
|
|
PROTAC Linkers
|
Cancer
|
|
Amino-PEG36-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-140006
-
|
|
PROTAC Linkers
|
Cancer
|
|
Diketone-PEG4-PFP ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-140616
-
|
DNP-PEG6-t-butyl ester
|
PROTAC Linkers
|
Cancer
|
|
DNP-PEG6-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-140210
-
|
|
PROTAC Linkers
|
Cancer
|
|
Amino-PEG9-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-141203
-
|
|
PROTAC Linkers
|
Cancer
|
|
Hydroxy-PEG7-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-132114
-
|
|
PROTAC Linkers
|
Cancer
|
|
Biotin-PEG3-pyridinrthiol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-133348
-
|
|
PROTAC Linkers
|
Cancer
|
|
m-PEG12-Hydrazide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-141096
-
|
|
PROTAC Linkers
|
Cancer
|
|
Acid-PEG9-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-133281
-
|
|
PROTAC Linkers
|
Cancer
|
|
m-PEG16-Br is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-130216
-
|
|
PROTAC Linkers
|
Cancer
|
|
THP-PEG3-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-W096139
-
|
|
PROTAC Linkers
|
Cancer
|
|
Br-PEG3-ethyl acetate is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-133277
-
|
|
PROTAC Linkers
|
Cancer
|
|
m-PEG2-Br is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-133282
-
|
|
PROTAC Linkers
|
Cancer
|
|
m-PEG24-Br is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-133353
-
|
|
PROTAC Linkers
|
Cancer
|
|
Mal-PEG6-mal is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-134683
-
|
|
PROTAC Linkers
|
Cancer
|
|
Ms-PEG3-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-133297
-
|
HS-PEG12-OH
|
PROTAC Linkers
|
Cancer
|
|
Thiol-PEG12-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-138721
-
|
|
PROTAC Linkers
|
Cancer
|
|
Fmoc-PEG10-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-140505
-
|
|
PROTAC Linkers
|
Cancer
|
|
m-PEG3-Propanoyl chloride is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-141159A
-
|
|
PROTAC Linkers
|
Cancer
|
|
(S)-TCO-PEG4-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-W190795
-
|
|
PROTAC Linkers
|
Cancer
|
|
Benzyl-PEG3-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-140175
-
|
|
PROTAC Linkers
|
Cancer
|
|
Butoxycarbonyl-PEG5-sulfonic acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-141275
-
|
|
PROTAC Linkers
|
Cancer
|
|
Methyltetrazine-PEG5-alkyne is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-W042579
-
|
|
PROTAC Linkers
|
Cancer
|
|
TBDMS-PEG4-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-141204
-
|
|
PROTAC Linkers
|
Cancer
|
|
Hydroxy-PEG7-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-133212
-
|
|
PROTAC Linkers
|
Cancer
|
|
Mal-PEG8-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-140749
-
|
|
PROTAC Linkers
|
Cancer
|
|
BnO-PEG5-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-133287
-
|
|
PROTAC Linkers
|
Cancer
|
|
m-PEG36-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-140754
-
|
|
PROTAC Linkers
|
Cancer
|
|
Bromoacetamido-PEG5-DOTA is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-134676
-
|
Triethylene glycol diallyl ether
|
PROTAC Linkers
|
Cancer
|
|
Propenyl-PEG3-Propenyl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-140511
-
|
|
PROTAC Linkers
|
Cancer
|
|
Acid-PEG3-PFP ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-134703
-
|
|
PROTAC Linkers
|
Cancer
|
|
Acid-PEG12-CHO is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-138338
-
|
|
PROTAC Linkers
|
Cancer
|
|
Benzyl-PEG9-THP is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-140898
-
|
|
PROTAC Linkers
|
Cancer
|
|
Biotin-PEG7-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-140451
-
|
|
PROTAC Linkers
|
Cancer
|
|
Diketone-PEG11-Diketone is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-132018
-
|
|
PROTAC Linkers
|
Cancer
|
|
Bromo-PEG2-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-133316
-
|
|
PROTAC Linkers
|
Cancer
|
|
HO-PEG4-benzyl ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-140382
-
|
|
PROTAC Linkers
|
Cancer
|
|
Ms-PEG2-MS is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-132115
-
|
|
PROTAC Linkers
|
Cancer
|
|
Biotin-PEG3-SH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-130399
-
|
|
PROTAC Linkers
|
Cancer
|
|
Mal-amido-PEG6-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-135049
-
|
|
PROTAC Linkers
|
Cancer
|
|
Bromo-PEG6-bromide is a PEG-based PROTAC linker can be used in the synthesis of PROTACs .
|
-
- HY-134704
-
|
|
PROTAC Linkers
|
Cancer
|
|
Biotin-PEG4-SH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-133284
-
|
|
PROTAC Linkers
|
Cancer
|
|
m-PEG48-Br is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-140373
-
|
|
PROTAC Linkers
|
Cancer
|
|
Tos-PEG21-Tos is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-141171
-
|
|
PROTAC Linkers
|
Cancer
|
|
TCO-PEG24-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-133389
-
|
|
PROTAC Linkers
|
Cancer
|
|
Mal-PEG36-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-133330
-
|
H2N-PEG27-CH2CH2NH2
|
PROTAC Linkers
|
Cancer
|
|
Amino-PEG27-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-141083
-
|
|
PROTAC Linkers
|
Cancer
|
|
Fluorescein-PEG6-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-141082
-
|
|
PROTAC Linkers
|
Cancer
|
|
Fluorescein-PEG5-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-141270
-
|
|
PROTAC Linkers
|
Cancer
|
|
Methyltetrazine-PEG8-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-138378
-
|
|
PROTAC Linkers
|
Cancer
|
|
Benzyl-PEG5-NHBoc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-134722
-
|
|
PROTAC Linkers
|
Cancer
|
|
Hydrazide-PEG4-Desthiobiotin is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-141338
-
|
|
PROTAC Linkers
|
Cancer
|
|
Lipoamide-PEG3-Mal is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-138727
-
|
|
PROTAC Linkers
|
Cancer
|
|
Mal-amido-PEG3-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-W190970
-
|
|
PROTAC Linkers
|
Cancer
|
|
Biotin-PEG9-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-141328
-
|
Thiol-PEG4-t-butyl ester
|
PROTAC Linkers
|
Cancer
|
|
Thiol-PEG4-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-141262
-
|
|
PROTAC Linkers
|
Cancer
|
|
Methyltetrazine-PEG24-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-W143484
-
|
|
PROTAC Linkers
|
Cancer
|
|
Fmoc-PEG3-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-117028
-
|
|
PROTAC Linkers
|
Cancer
|
|
Tos-PEG7-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-140370
-
|
|
PROTAC Linkers
|
Cancer
|
|
Tos-PEG9-Tos is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-138450
-
|
|
PROTAC Linkers
|
Cancer
|
|
Br-PEG4-methyl acetate is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-141308
-
|
|
PROTAC Linkers
|
Cancer
|
|
m-PEG5-phosphonic acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-132092
-
|
|
PROTAC Linkers
|
Cancer
|
|
Methyl-PEG3-Ald is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-126917
-
|
|
PROTAC Linkers
|
Cancer
|
|
THP-PEG5-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-140461
-
|
|
PROTAC Linkers
|
Cancer
|
|
Fmoc-NH-PEG10-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-141226
-
|
|
PROTAC Linkers
|
Cancer
|
|
m-PEG36-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-138498
-
|
|
PROTAC Linkers
|
Cancer
|
|
F-PEG2-COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-141318
-
|
|
PROTAC Linkers
|
Cancer
|
|
Thiol-PEG3-phosphonic acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-132009
-
|
|
PROTAC Linkers
|
Cancer
|
|
Benzyl-PEG7-bromide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-138531
-
|
|
PROTAC Linkers
|
Cancer
|
|
THP-PEG1-THP is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-133456
-
|
|
PROTAC Linkers
|
Cancer
|
|
Biotin-PEG2-aldehyde is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-138426
-
|
|
PROTAC Linkers
|
Cancer
|
|
Biotin-PEG4-allyl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-140412
-
|
|
PROTAC Linkers
|
Cancer
|
|
Boc-Aminooxy-PEG3-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-130891
-
|
|
PROTAC Linkers
|
Cancer
|
|
(+)-Biotin-PEG6-hydrazide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-133276
-
|
|
PROTAC Linkers
|
Cancer
|
|
m-PEG7-Br is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-135924
-
|
|
PROTAC Linkers
|
Cancer
|
|
Biotin-PEG3-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-140743
-
|
|
PROTAC Linkers
|
Cancer
|
|
Benzyl-PEG5-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-132072
-
|
|
PROTAC Linkers
|
Cancer
|
|
THP-PEG8-THP is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-141184
-
|
|
PROTAC Linkers
|
Cancer
|
|
TCO-PEG9-maleimide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-141173
-
|
|
PROTAC Linkers
|
Cancer
|
|
TCO-PEG8-TFP ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-135921
-
|
|
PROTAC Linkers
|
Cancer
|
|
m-PEG5-Hydrazide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-W019794
-
|
|
PROTAC Linkers
|
Cancer
|
|
Mal-PEG16-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-140199
-
|
|
PROTAC Linkers
|
Cancer
|
|
Amino-PEG24-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-138423
-
|
|
PROTAC Linkers
|
Cancer
|
|
Acryloyl-PEG4-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-140174
-
|
|
PROTAC Linkers
|
Cancer
|
|
Boc-PEG4-sulfonic acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-133272
-
|
|
PROTAC Linkers
|
Cancer
|
|
m-PEG5-SH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-140205
-
|
|
PROTAC Linkers
|
Cancer
|
|
Amino-PEG12-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-130195
-
|
|
PROTAC Linkers
|
Cancer
|
|
SPDP-PEG4-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-140490
-
|
|
PROTAC Linkers
|
Cancer
|
|
Cbz-N-PEG10-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-153153
-
|
|
PROTAC Linkers
|
Cancer
|
|
Benzyl-PEG45-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-141331
-
|
|
PROTAC Linkers
|
Cancer
|
|
m-PEG12-Thiol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-140515
-
|
|
PROTAC Linkers
|
Cancer
|
|
NH-bis(PEG3-acid) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-141107
-
|
|
PROTAC Linkers
|
Cancer
|
|
m-PEG13-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-42774
-
|
1,11-Bis(methanesulfonyloxy)-3,6,9-trioxandecane
|
PROTAC Linkers
|
Cancer
|
|
Ms-PEG4-MS is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-132051
-
|
|
PROTAC Linkers
|
Cancer
|
|
Benzyl-PEG14-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-138433
-
|
|
PROTAC Linkers
|
Cancer
|
|
Benzyl-PEG1-propanol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-133350
-
|
|
PROTAC Linkers
|
Cancer
|
|
m-PEG17-Hydrazide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-132105
-
|
|
PROTAC Linkers
|
Cancer
|
|
Benzyl-PEG6-THP is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-140448
-
|
|
PROTAC Linkers
|
Cancer
|
|
Diketone-PEG4-Biotin is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-133454
-
|
|
PROTAC Linkers
|
Cancer
|
|
Mal-PEG2-oxyamine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-132029
-
|
|
PROTAC Linkers
|
Cancer
|
|
Benzyl-PEG6-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-141294
-
|
|
PROTAC Linkers
|
Cancer
|
|
PEG3-bis(phosphonic acid) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-138479
-
|
|
PROTAC Linkers
|
Cancer
|
|
Benzyl-PEG2-ethanol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-140371
-
|
|
PROTAC Linkers
|
Cancer
|
|
Tos-PEG12-Tos is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-141097
-
|
|
PROTAC Linkers
|
Cancer
|
|
Acid-PEG13-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-140396A
-
|
|
PROTAC Linkers
|
Cancer
|
|
Aminooxy-PEG3-bromide hydrochloride is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-138336
-
|
|
PROTAC Linkers
|
Cancer
|
|
Br-PEG3-MS is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-W096156
-
|
|
PROTAC Linkers
|
Cancer
|
|
I-PEG6-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-140966
-
|
|
PROTAC Linkers
|
Cancer
|
|
Mal-PEG12-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-140969
-
|
|
PROTAC Linkers
|
Cancer
|
|
Mal-PEG3-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-138368
-
|
|
PROTAC Linkers
|
Cancer
|
|
THP-PEG1-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-132028
-
|
|
PROTAC Linkers
|
Cancer
|
|
Benzyl-PEG6-bromide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-140196
-
|
|
PROTAC Linkers
|
Cancer
|
|
Amino-PEG10-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-132074
-
|
|
PROTAC Linkers
|
Cancer
|
|
Benzyl-PEG11-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-141307
-
|
|
PROTAC Linkers
|
Cancer
|
|
m-PEG4-phosphonic acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-138720
-
|
|
PROTAC Linkers
|
Cancer
|
|
Fmoc-PEG9-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-140229
-
|
|
PROTAC Linkers
|
Cancer
|
|
m-PEG36-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-134707
-
|
|
PROTAC Linkers
|
Cancer
|
|
CHO-PEG12-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-140404
-
|
|
PROTAC Linkers
|
Cancer
|
|
Aminooxy-PEG3-methyl ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-138335
-
|
|
PROTAC Linkers
|
Cancer
|
|
Boc-PEG8-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-138759
-
|
|
PROTAC Linkers
|
Cancer
|
|
Thiol-PEG3-NHBoc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-140209
-
|
|
PROTAC Linkers
|
Cancer
|
|
Amino-PEG7-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-133210
-
|
|
PROTAC Linkers
|
Cancer
|
|
Mal-PEG5-PFP ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-140974
-
|
|
PROTAC Linkers
|
Cancer
|
|
Mal-amido-PEG12-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-132077
-
|
|
PROTAC Linkers
|
Cancer
|
|
THP-PEG16-THP is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-138420
-
|
|
PROTAC Linkers
|
Cancer
|
|
m-PEG7-Silane is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-130907
-
|
|
PROTAC Linkers
|
Cancer
|
|
Fmoc-N-PEG24-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-130856
-
|
Maleimide-NH-PEG9-CH2CH2COOH
|
PROTAC Linkers
|
Cancer
|
|
Mal-amido-PEG9-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-138434
-
|
|
PROTAC Linkers
|
Cancer
|
|
Fmoc-NH-PEG14-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-125534
-
|
|
PROTAC Linkers
|
Cancer
|
|
Tos-PEG9-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-132942A
-
-
- HY-141306
-
|
|
PROTAC Linkers
|
Cancer
|
|
m-PEG2-phosphonic acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-141205
-
|
|
PROTAC Linkers
|
Cancer
|
|
Hydroxy-PEG9-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-W096074
-
|
|
PROTAC Linkers
|
Cancer
|
|
MS-PEG4-THP is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-130833
-
|
|
PROTAC Linkers
|
Cancer
|
|
Hydroxy-PEG16-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-W096145
-
|
|
PROTAC Linkers
|
Cancer
|
|
Chloro-PEG2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-W096071
-
|
|
PROTAC Linkers
|
Cancer
|
|
Bromo-PEG2-THP is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-134747
-
|
|
PROTAC Linkers
|
Cancer
|
|
THP-PEG10-THP is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-140959
-
|
|
PROTAC Linkers
|
Cancer
|
|
DSPE-PEG13-TFP ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-130832
-
|
|
PROTAC Linkers
|
Cancer
|
|
Hydroxy-PEG13-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-130348
-
|
|
PROTAC Linkers
|
Cancer
|
|
OPSS-PEG8-COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-W004697
-
|
|
PROTAC Linkers
|
Cancer
|
|
Boc-GABA-OH is a PROTAC linker which can be used to synthesis UNC6852, an EED-targeted PROTAC .
|
-
- HY-W096107
-
|
|
PROTAC Linkers
|
Cancer
|
|
Benzyl-PEG8-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-140195
-
|
|
PROTAC Linkers
|
Cancer
|
|
Amino-PEG9-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-143832
-
|
|
PROTAC Linkers
|
Cancer
|
|
Cbz-PEG5-Br is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-130855
-
|
Mal-NH-PEG7-COOH; Maleimide-NH-PEG7-CH2CH2COOH
|
PROTAC Linkers
|
Cancer
|
|
Mal-amido-PEG7-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-141207
-
|
|
PROTAC Linkers
|
Cancer
|
|
Hydroxy-PEG20-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-133379
-
|
|
PROTAC Linkers
|
Cancer
|
|
Biotin-PEG12-Mal is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-140363
-
|
|
PROTAC Linkers
|
Cancer
|
|
m-PEG3-OMs is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-133349
-
|
|
PROTAC Linkers
|
Cancer
|
|
m-PEG13-Hydrazide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-138340
-
|
|
PROTAC Linkers
|
Cancer
|
|
THP-PEG8-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-140701
-
|
|
PROTAC Linkers
|
Cancer
|
|
m-PEG-Succinimidyl Succinate (MW 5000) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-140936
-
|
|
PROTAC Linkers
|
Cancer
|
|
Biotin-PEG6-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-141098
-
|
|
PROTAC Linkers
|
Cancer
|
|
Acid-PEG25-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-140170
-
|
|
PROTAC Linkers
|
Cancer
|
|
m-PEG4-sulfonic acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-133000
-
|
|
PROTAC Linkers
|
Cancer
|
|
Bis-PEG7-PFP ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-138371
-
|
|
PROTAC Linkers
|
Cancer
|
|
MS-PEG12-THP is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-141261
-
|
|
PROTAC Linkers
|
Cancer
|
|
Methyltetrazine-PEG4-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-141214
-
|
|
PROTAC Linkers
|
Cancer
|
|
Bromo-PEG5-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-130496
-
|
|
PROTAC Linkers
|
Cancer
|
|
Ald-Ph-PEG6-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-141283
-
|
|
PROTAC Linkers
|
Cancer
|
|
Methyltetrazine-PEG5-triethoxysilane is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-138419
-
|
|
PROTAC Linkers
|
Cancer
|
|
Biotin-PEG6-Silane is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-133270
-
|
|
PROTAC Linkers
|
Cancer
|
|
m-PEG10-SH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-138427
-
|
|
PROTAC Linkers
|
Cancer
|
|
m-PEG18-Mal is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-133347
-
|
|
PROTAC Linkers
|
Cancer
|
|
m-PEG11-Hydrazide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-132090
-
|
|
PROTAC Linkers
|
Cancer
|
|
Acid-PEG3-SSPy is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-140154
-
|
Methylamino-PEG1-t-butyl ester
|
PROTAC Linkers
|
Cancer
|
|
Methylamino-PEG1-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-141397
-
|
Methyl-peg8-t-butyl ester
|
PROTAC Linkers
|
Cancer
|
|
m-PEG8-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-140986
-
|
|
PROTAC Linkers
|
Cancer
|
|
m-PEG48-Mal is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-138329
-
|
|
PROTAC Linkers
|
Cancer
|
|
THP-PEG24-THP is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-130829
-
|
|
PROTAC Linkers
|
Cancer
|
|
m-PEG15-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-114843
-
|
|
PROTAC Linkers
|
Cancer
|
|
Benzyl-PEG1-Tos is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-140894
-
|
|
PROTAC Linkers
|
Cancer
|
|
Biotin-PEG8-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-140891
-
|
|
PROTAC Linkers
|
Cancer
|
|
Biotin-PEG8-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-138314
-
|
|
PROTAC Linkers
|
Cancer
|
|
m-PEG16-COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-W096105
-
|
|
PROTAC Linkers
|
Cancer
|
|
Nonylbenzene-PEG5-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-138728
-
|
|
PROTAC Linkers
|
Cancer
|
|
Mal-amido-PEG5-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-138404
-
|
|
PROTAC Linkers
|
Cancer
|
|
THP-PEG2-Mal is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-133280
-
|
|
PROTAC Linkers
|
Cancer
|
|
m-PEG9-SH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-133293
-
|
HS-PEG5-OH
|
PROTAC Linkers
|
Cancer
|
|
Thiol-PEG5-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-138315
-
|
|
PROTAC Linkers
|
Cancer
|
|
Ms-PEG6-THP is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-140198
-
|
|
PROTAC Linkers
|
Cancer
|
|
Amino-PEG20-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-132024
-
|
|
PROTAC Linkers
|
Cancer
|
|
Bromo-PEG4-MS is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-141228
-
|
|
PROTAC Linkers
|
Cancer
|
|
THP-PEG8-Tos is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-W190843
-
|
|
PROTAC Linkers
|
Cancer
|
|
Bromo-PEG2-acetic acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-140726
-
|
|
PROTAC Linkers
|
Cancer
|
|
Boc-NH-PEG-amine (MW 3400) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-133269
-
|
|
PROTAC Linkers
|
Cancer
|
|
m-PEG11-SH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-W190968
-
|
|
PROTAC Linkers
|
Cancer
|
|
Cbz-PEG2-bromide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-132020
-
|
|
PROTAC Linkers
|
Cancer
|
|
Tos-PEG2-THP is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-140901
-
|
|
PROTAC Linkers
|
Cancer
|
|
Biotin-PEG23-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-133326
-
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