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Results for "

PTEN

" in MedChemExpress (MCE) Product Catalog:

By Targets:	PTEN (9) Adrenergic Receptor (2) Akt (13) Angiotensin Receptor (2) Antibiotic (1) Apoptosis (9) Autophagy (8) Bacterial (1) E1/E2/E3 Enzyme (1) ERK (1) Interleukin Related (1) MDM-2/p53 (1) MicroRNA (1) NF-κB (1) Organoid (3) Parasite (2) PARP (1) Phosphatase (4) PI3K (4) PPAR (1) Prostaglandin Receptor (1) PROTACs (1) Ser/Thr Protease (1) Small Interfering RNA (siRNA) (3) TNF Receptor (1)
By Research Areas:	Cancer (23) Cardiovascular Disease (4) Endocrinology (3) Infection (3) Inflammation/Immunology (4) Metabolic Disease (4) Neurological Disease (1)

Inhibitors & Agonists

Screening Libraries

Natural
Products

Antibodies

Targets Recommended: PTEN

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-128693

BpV(HOpic) 2 Publications Verification	PTEN	Neurological Disease Cancer
BpV(HOpic) is a potent and selective inhibitor of *PTEN* with an IC₅₀ of 14 nM. Nanocarrier-BpV(HOpic) has neuroprotective activity .

HY-RS11363

PTEN Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
PTEN Human Pre-designed siRNA Set A contains three designed siRNAs for PTEN gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

PTEN Human Pre-designed siRNA Set A PTEN Human Pre-designed siRNA Set A

HY-RS11364

Pten Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Pten Mouse Pre-designed siRNA Set A contains three designed siRNAs for Pten gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Pten Mouse Pre-designed siRNA Set A Pten Mouse Pre-designed siRNA Set A

HY-RS11365

Pten Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Pten Rat Pre-designed siRNA Set A contains three designed siRNAs for Pten gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Pten Rat Pre-designed siRNA Set A Pten Rat Pre-designed siRNA Set A

HY-136065

bpV(phen)	PTEN Phosphatase Parasite Apoptosis	Infection Metabolic Disease Inflammation/Immunology Cancer
bpV(phen), a insulin-mimetic agent, is a potent protein tyrosine phosphatase (PTP) and *PTEN* inhibitor with IC₅₀s of 38 nM, 343 nM and 920 nM for *PTEN, PTP-β* and PTP-1B, respectively. bpV(phen) inhibits proliferation of the protozoan parasite Leishmania in vitro. bpV(phen) strongly induces the secretion of a large number of chemokines and pro-inflammatory cytokines, and it activates a Th1-type pathway (IL-12, IFNγ). bpV(phen) can also induce cell apoptosis, and has anti-angiogenic and anti-tumor activity .

HY-108232

MK-2206	Organoid Akt Autophagy Apoptosis	Cancer
MK-2206 is an orally active, highly potent and selective allosteric Akt inhibitor, with IC₅₀s of 8, 12, and 65 nM for Akt1, Akt2, and Akt3, respectively. Many breast cancer cell lines, and PIK3CA-mutant and cell lines with PTEN loss are sensitive to MK-2206. MK-2206 has anticancer activities .

HY-147783

Anticancer agent 68	MDM-2/p53	Cancer
Anticancer agent 68 is (Compound 12) is an anti-cancer agent. Anticancer agent 68 arrests the cells at the G2/M phase and induces programmed cell death. Anticancer agent 68 induces upregulation of tumor suppression via activation of p53 & PTEN .

HY-137458

Vevorisertib ARQ 751	Akt Ser/Thr Protease	Cancer
Vevorisertib (ARQ 751) is an orally active, potent and selective pan-AKT serine/threonine kinase inhibitor against AKT1 (IC₅₀=0.55 nM), AKT2 (IC₅₀=0.81 nM), and AKT3 (IC₅₀=1.31 nM). Vevorisertib, as a single agent or in combination with other anti-cancer agents, can be used for the research of solid tumors with PIK3CA / AKT / PTEN mutations .

HY-10357

MK-2206 free base	Organoid Akt Autophagy Apoptosis	Cancer
MK-2206 free base is an orally active, highly potent and selective allosteric Akt inhibitor, with IC₅₀s of 8, 12, and 65 nM for Akt1, Akt2, and Akt3, respectively. Many breast cancer cell lines, and PIK3CA-mutant and cell lines with PTEN loss are sensitive to MK-2206 free base. MK-2206 free base has anticancer activities .

HY-13074

VO-Ohpic trihydrate

25+ Cited Publications

PTEN Autophagy Cancer

VO-Ohpic trihydrate is a highly potent inhibitor of PTEN with an IC₅₀ of 46±10 nM.
HY-15842

SF1670

10+ Cited Publications

PTEN Phosphatase Autophagy Cancer

SF1670 is a potent and specific phosphatase and tensin homolog deleted on chromosome 10 (PTEN) inhibitor .

VO-Ohpic trihydrate 25+ Cited Publications	PTEN Autophagy	Cancer
VO-Ohpic trihydrate is a highly potent inhibitor of *PTEN* with an IC₅₀ of 46±10 nM.

SF1670 10+ Cited Publications	PTEN Phosphatase Autophagy	Cancer
SF1670 is a potent and specific phosphatase and tensin homolog deleted on chromosome 10 (PTEN) inhibitor .

HY-122818

bpV(phen) trihydrate 2 Publications Verification	PTEN Phosphatase Parasite Apoptosis	Infection Metabolic Disease Inflammation/Immunology Cancer
bpV(phen) trihydrate, a insulin-mimetic agent, is a potent protein tyrosine phosphatase (PTP) and *PTEN* inhibitor with IC₅₀s of 38 nM, 343 nM and 920 nM for *PTEN, PTP-β* and PTP-1B, respectively. bpV(phen) trihydrate inhibits proliferation of the protozoan parasite Leishmania in vitro. bpV(phen) trihydrate strongly induces the secretion of a large number of chemokines and pro-inflammatory cytokines, and it activates a Th1-type pathway (IL-12, IFNγ). bpV(phen) trihydrate can also induce cell apoptosis, and has anti-angiogenic and anti-tumor activity .

HY-141807

MS21

PROTACs Akt Cancer

MS21, a novel degrader of AKT, selectively inhibits the growth of PI3K/PTEN pathway-mutant cancers with wild-type KRAS and BRAF.

MS21	PROTACs Akt	Cancer
MS21, a novel degrader of AKT, selectively inhibits the growth of PI3K/PTEN pathway-mutant cancers with wild-type KRAS and BRAF.

HY-110067

VO-OHPic	PTEN Apoptosis Autophagy	Cardiovascular Disease Metabolic Disease Inflammation/Immunology Cancer
VO-OHPic is a reversible, noncompetitive and selective *PTEN* inhibitor with an IC₅₀ of 46 nM. VO-OHPic attenuates apoptosis, adverse cardiac remodeling, and pro-inflammatory M1 macrophages in doxorubicin-induced cardiomyopathy. VO-OHPic inhibits autophagy .

HY-156382

SPOP-IN-1	Akt ERK E1/E2/E3 Enzyme	Cancer
SPOP-IN-1 is a selective SPOP E3 ubiquitin ligase inhibitor. SPOP-IN-1 leads to the accumulation of tumor suppressors PTEN and DUSP7 and decreased levels of phosphorylated AKT and ERK in clear-cell renal cell carcinoma .

HY-N2116

Ginkgolic acid C17:1	PTEN Phosphatase	Cancer
Ginkgolic acid C17:1, extracted from Ginkgo biloba Leaves, suppresses constitutive and inducible STAT3 activation through induction of *PTEN* and SHP-1 tyrosine phosphatase. Ginkgolic acid C17:1 has anticancer effects .

HY-100886

BAY1082439
BAY1082439 is an orally bioavailable, selective PI3Kα/β/δ inhibitor. BAY1082439 also inhibits mutated forms of PIK3CA. BAY1082439 is highly effective in inhibiting Pten-null prostate cancer growth .

HY-160093

SQLE-IN-1	PTEN Akt PI3K	Metabolic Disease
SQLE-IN-1 (compound 19) is a squalene epoxidase (SQLE) inhibitor. SQLE-IN-1 inhibits the proliferation and migration of Huh7 cells. SQLE-IN-1 inhibits the cell cholesterol generation. SQLE-IN-1 increases the expression of *PTEN* and inhibits PI3K and AKT .

HY-128932

Cefminox sodium 1 Publications Verification MT-141	Bacterial PPAR Prostaglandin Receptor Antibiotic	Infection Cardiovascular Disease Endocrinology
Cefminox sodium (MT-141) is a semisynthetic cephamycin, which exhibits a broad spectrum of antibacterial activity . Cefminox sodium (MT-141) also acts as a dual agonist of prostacyclin receptor (IP) and PPARγ, upregulates cAMP production and PTEN expression and inhibits Akt/mTOR signaling. Cefminox sodium (MT-141) also prevents pulmonary arterial hypertension .

HY-N8884

Coelonin	PTEN Akt NF-κB Interleukin Related TNF Receptor	Inflammation/Immunology
Coelonin is a dihydrophenanthrene with anti-inflammation activity. Coelonin inhibits LPS-induced *PTEN* phosphorylation. Coelonin inhibits NF-κB activation and p27Kip1 degradation by regulating the PI3K/AKT pathway negatively. Coelonin can inhibit IκBα phosphorylation and degradation and increases the expression of IκBα protein .

HY-122615A

SPOP-IN-6b hydrochloride

Others Cancer

SPOP-IN-6b hydrochloride is a potent speckle-type POZ protein (SPOP) inhibitor with an IC₅₀ of 3.58 μM .
HY-122615B

SPOP-IN-6b dihydrochloride

1 Publications Verification

Others Cancer

SPOP-IN-6b dihydrochloride is a potent speckle-type POZ protein (SPOP) inhibitor with an IC₅₀ of 3.58 μM .

SPOP-IN-6b hydrochloride	Others	Cancer
SPOP-IN-6b hydrochloride is a potent speckle-type POZ protein (SPOP) inhibitor with an IC₅₀ of 3.58 μM .

SPOP-IN-6b dihydrochloride 1 Publications Verification	Others	Cancer
SPOP-IN-6b dihydrochloride is a potent speckle-type POZ protein (SPOP) inhibitor with an IC₅₀ of 3.58 μM .

HY-N1435

Oroxin B 2 Publications Verification
Oroxin B (OB) is a flavonoid isolated from traditional Chinese herbal medicine Oroxylum indicum (L.) Vent. Oroxin B (OB) possesses obvious inhibitory effect and induces early apoptosis rather than late apoptosis on liver cancer cells through upregulation of *PTEN*, down regulation of COX-2, VEGF, PI3K, and p-AKT . Oroxin B (OB) selectively induces tumor-suppressive ER stress in malignant lymphoma cells .

HY-15477

YS-49 5+ Cited Publications	Akt PI3K Angiotensin Receptor Adrenergic Receptor	Cardiovascular Disease Endocrinology
YS-49 is a PI3K/Akt (a downstream target of RhoA) activator, to reduce RhoA/PTEN activation in the 3-methylcholanthrene-treated cells. YS-49 inhibits angiotensin II (Ang II)-stimulated proliferation of VSMCs via induction of heme oxygenase (HO)-1. YS-49 is also an isoquinoline compound alkaloid, has a strong positive inotropic action through activation of cardiac β-adrenoceptors .

HY-15477A

YS-49 monohydrate	Akt PI3K Angiotensin Receptor Adrenergic Receptor	Cardiovascular Disease Endocrinology
YS-49 (monohydrate) is a PI3K/Akt (a downstream target of RhoA) activator, to reduce RhoA/PTEN activation in the 3-methylcholanthrene-treated cells. YS-49 inhibits angiotensin II (Ang II)-stimulated proliferation of VSMCs via induction of heme oxygenase (HO)-1. YS-49 is also an isoquinoline compound alkaloid, has a strong positive inotropic action through activation of cardiac β-adrenoceptors .

HY-18686

AS1949490
AS1949490 is a potent, orally active, selective SHIP2 phosphatase inhibitor with IC₅₀ values of 0.34, 0.62, 13, >50, >50, and >50 µM for Mouse SHIP2, Human SHIP2, Human SHIP1, Human PTEN, Human synaptojanin, and Human myotubularin, respectively. AS1949490 increases the phosphorylation of Akt, glucose consumption and glucose uptake. AS1949490 activates intracellular insulin signalling pathways. AS1949490 can be used for research of diabetes .

HY-101115

PI3K-IN-6	PI3K	Cancer
PI3K-IN-6 (compound 20a) is an oral active and highly selective phosphoinositide 3-kinase (PI3K) β/δ inhibitor, with IC₅₀ values of 7.8 nM/5.3 nM for PI3K β/δ, respectively. PI3K-IN-6 (compound 20a) has potential top treat phosphatase and tensin homolog (PTEN) feficient tumors .

HY-10358

MK-2206 dihydrochloride Maximum Cited Publications 286 Publications Verification MK-2206 (2HCl)	Organoid Akt Autophagy Apoptosis	Cancer
MK-2206 dihydrochloride (MK-2206 (2HCl)) is an orally active, BBB-penetrated allosteric AKT inhibitor with IC₅₀s of 5 nM, 12 nM, and 65 nM for AKT1, AKT2, and AKT3, respectively. MK-2206 dihydrochloride induces autophagy .

HY-115552

Simmiparib	PARP	Cancer
Simmiparib is a highly potent and orally active PARP1 and PARP2 inhibitor with IC₅₀ values of 1.75 nM and 0.22 nM, respectively. Simmiparib has more potent PARP1/2 inhibition than its parent Olaparib (HY-10162). Simmiparib induces DNA double-strand breaks (DSB) accumulation and G2/M arrest in homologous recombination repair (HR)-deficient cells, thereby inducing apoptosis. Simmiparib exhibits remarkable anticancer activities in cells and nude mice bearing xenografts .

HY-146411

microRNA-21-IN-1	MicroRNA Apoptosis	Cancer
microRNA-21-IN-1 (compound A7) is an efficient microRNA inhibitor. microRNA-21-IN-1 has antiproliferative activity against Hela and HCT-116 cells with IC₅₀s of 5.5 μM and 2.8 μM respectively, as well as promotes apoptosis of Hela cells. microRNA-21-IN-1 upregulates the expression of microRNA-21 downstream functional targets (PTEN, EGR1 and SLIT2). microRNA-21-IN-1 can be used for researching anticancer .

HY-137458A

Vevorisertib trihydrochloride ARQ 751 trihydrochloride	Akt	Cancer
Vevorisertib (ARQ 751) trihydrochloride is a selective, allosteric, pan-AKT and AKT1-E17K mutant inhibitors. Vevorisertib trihydrochloride potently inhibit phosphorylation of AKT. Vevorisertib trihydrochloride has Kd values of 1.2 nM and 8.6 nM for AKT1 and AKT1-E17K, respectively. Vevorisertib trihydrochloride has IC₅₀ values of 0.55, 0.81, and 1.3 nM for AKT1, AKT2, and AKT3, respectively. Vevorisertib trihydrochloride can be used for the research of cancer .

HY-134417

NSC2805	Others	Cancer
NSC2805 is a WWP2 ubiquitin ligase inhibitor that can significant inhibit WWP2 activity with an IC₅₀ of 0.38 μM. NSC2805 can be used for the research of cancer .

HY-13260

CCT128930 3 Publications Verification	Akt Autophagy Apoptosis	Cancer
CCT128930 is a ATP-competitive and selective inhibitor of AKT (IC₅₀=6 nM for AKT2). CCT128930 has 28-fold selectivity over the closely related PKA kinase (IC₅₀=168 nM) through the targeting of Met282 of AKT (Met173 of PKA-AKT chimera), as well as 20-fold selectivity over p70S6K (IC₅₀=120 nM). Antitumor activity.

HY-13260A

CCT128930 hydrochloride 3 Publications Verification	Akt Autophagy Apoptosis	Cancer
CCT128930 hydrochloride is a potent and selective inhibitor of AKT (IC₅₀=6 nM). CCT128930 hydrochloride has 28-fold selectivity over the closely related PKA kinase (IC₅₀=168 nM) through the targeting of Met282 of AKT (Met173 of PKA-AKT chimera), as well as 20-fold selectivity over p70S6K (IC₅₀=120 nM). CCT128930 hydrochloride induces cell cycle arrest, DNA damage, and autophagy. Antitumor activity .

PI3K/Akt/mTOR Compound Library	568 compounds
The PI3K/Akt/mTOR pathway controls many cellular processes that are important for the formation and progression of cancer, including apoptosis, transcription, translation, metabolism, angiogenesis, and cell cycle progression. Every major node of this signaling network is activated in a wide range of human tumors. Mechanisms for the pathway activation include activation of receptor tyrosine kinases (RTKs) upstream of PI3K, mutation or amplification of PIK3CA encoding p110α catalytic subunit of PI3K, mutation or loss of PTEN tumor suppressor gene, and mutation or amplification of Akt1. Once the pathway is activated, signaling through Akt can stimulate a series of substrates including mTOR which is involved in protein synthesis. Thus, inhibition of this pathway is an attractive concept for cancer prevention and/or therapy. Currently some mTOR inhibitors are approved for several indications, and there are several novel PI3K/Akt/mTOR inhibitors in clinical trials. MCE owns a unique collection of 568 compounds that can be used for PI3K/Akt/mTOR pathway research. PI3K/Akt/mTOR Compound Library also acts as a useful tool for anti-cancer drug discovery.

Ginkgolic acid C17:1	Monophenols Classification of Application Fields Ginkgoaceae Ketones, Aldehydes, Acids Source classification Phenols Plants Disease Research Fields Ginkgo biloba Cancer	PTEN Phosphatase
Ginkgolic acid C17:1, extracted from Ginkgo biloba Leaves, suppresses constitutive and inducible STAT3 activation through induction of *PTEN* and SHP-1 tyrosine phosphatase. Ginkgolic acid C17:1 has anticancer effects .

Coelonin	Structural Classification Appendicula reflexa Blume Orchidaceae Source classification Phenols Polyphenols Plants	PTEN Akt NF-κB Interleukin Related TNF Receptor
Coelonin is a dihydrophenanthrene with anti-inflammation activity. Coelonin inhibits LPS-induced *PTEN* phosphorylation. Coelonin inhibits NF-κB activation and p27Kip1 degradation by regulating the PI3K/AKT pathway negatively. Coelonin can inhibit IκBα phosphorylation and degradation and increases the expression of IκBα protein .

PTEN Antibody	WB, ICC/IF, IHC-P	Human, Mouse
PTEN Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 54 kDa, targeting to PTEN. It can be used for WB,ICC/IF,IHC-P assays with tag free, in the background of Human, Mouse.

*Phospho-PTEN* (Ser380) Antibody**	WB, ICC	Human
Phospho-PTEN (Ser380) Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 47 kDa, targeting to Phospho-PTEN(S380). It can be used for WB,ICC assays with tag free, in the background of Human.

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