PTK2

By Targets:	AAK1 (1) Anaplastic lymphoma kinase (ALK) (4) Aurora Kinase (1) Bcr-Abl (1) CaMK (1) CDK (2) Cyclin G-associated Kinase (GAK) (1) E3 Ligase Ligand-Linker Conjugates (1) FAK (2) Ferroptosis (2) Ligands for Target Protein for PROTAC (1) LIM Kinase (LIMK) (2) MAP4K (1) MAPKAPK2 (MK2) (1) PROTAC Linkers (1) PROTACs (6) Salt-inducible Kinase (SIK) (2) Small Interfering RNA (siRNA) (4) ULK (2) Wee1 (1)
By Research Areas:	Cancer (9)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-124625

BI-4464

FAK Ligands for Target Protein for PROTAC Cancer

BI-4464 is a highly selective ATP competitive inhibitor of PTK2/FAK, with an IC₅₀ of 17 nM. A PTK2 ligand for PROTAC .

BI-4464	FAK Ligands for Target Protein for PROTAC	Cancer
BI-4464 is a highly selective ATP competitive inhibitor of *PTK2/FAK, with an IC₅₀* of 17 nM. A PTK2 ligand for PROTAC .

HY-RS11399

PTK2 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)
PTK2 Human Pre-designed siRNA Set A contains three designed siRNAs for PTK2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

PTK2 Human Pre-designed siRNA Set A PTK2 Human Pre-designed siRNA Set A

HY-RS11400

Ptk2 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)
Ptk2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ptk2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Ptk2 Mouse Pre-designed siRNA Set A Ptk2 Mouse Pre-designed siRNA Set A

HY-RS11401

Ptk2 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)
Ptk2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Ptk2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Ptk2 Rat Pre-designed siRNA Set A Ptk2 Rat Pre-designed siRNA Set A

HY-RS11402

PTK2B Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)
PTK2B Human Pre-designed siRNA Set A contains three designed siRNAs for PTK2B gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

PTK2B Human Pre-designed siRNA Set A PTK2B Human Pre-designed siRNA Set A

HY-111546

BI-3663	PROTACs FAK	Cancer
BI-3663 is a highly selective *PTK2/FAK* PROTAC (DC₅₀=30 nM), with Cereblon ligands to hijack E3 ligases for PTK2 degradation. BI-3663 inhibits PTK2 with an IC₅₀ of 18 nM. BI-3663 is a PROTAC that composes of BI-4464 (HY-124625) linked to Pomalidomide (HY-10984) with a linker . Anti-cancer activity .

HY-130422

Tos-PEG4-t-butyl ester Tos-PEG4-Boc	PROTAC Linkers	Cancer
Tos-PEG4-t-butyl ester (Tos-PEG4-Boc) is a PROTAC linker, which refers to the PEG composition. Tos-PEG4-t-butyl ester (Tos-PEG4-Boc) can be used in the synthesis of a series of PROTACs, such as BI-3663 (HY-111546). BI-3663 is a highly selective PTK2/FAK PROTAC, with cereblon ligands to hijack E3 ligases for PTK2 degradation, and inhibits PTK2 with an IC₅₀ of 18 nM .

HY-123919

TL13-112 1 Publications Verification	PROTACs Anaplastic lymphoma kinase (ALK)	Cancer
TL13-112 is a potent and selective ALK-PROTAC degrader and inhibits ALK activity with an IC₅₀ value of 0.14 nM. TL13-112 also prompts the degradation of additional kinases including Aurora A, FER, *PTK2* and RPS6KA1 with IC₅₀ values of 8550 nM, 42.4 nM, 25.4 nM, and 677 nM, respectively. TL13-112 is comprised of the conjugation of Ceritinib (HY-15656) and the Cereblon ligand of Pomalidomide (HY-10984) .

HY-122582

TL13-12	PROTACs Anaplastic lymphoma kinase (ALK)	Cancer
TL13-12 is a potent and selective ALK-PROTAC degrader and inhibits ALK activity with an IC₅₀ value of 0.69 nM. TL13-12 also prompts the degradation of additional kinases including Aurora A, FER, *PTK2, and RPS6KA1* with IC₅₀ values of 13.5 nM, 5.74 nM, 18.4 nM, and 65 nM, respectively. TL13-12 is comprised of the conjugation of TAE684 (HY-10192) and the Cereblon ligand of Pomalidomide (HY-10984) .

HY-148065

FMF-06-098-1	PROTACs	Cancer
FMF-06-098-1 is a multitargeted depressant. FMF-06-098-1 can be used to target degradation kinases which degrades AAK1, AΒL2, AURKA, AURKB, BUBIB, CDC7, CDK1, CDK12, CDK13, CDK2, CDK4, CDk6, CDK7, CDK9, CHEK1, CSNKID, EPHA1, PER, FGFR1, GAK, IRAK4, ITK, LIMK2, MAP4K2, MAP4K3, MAPK6, MAPK7, MARK4, MELK, PKN3, PLK4, PRKAA1, PTK2, PTK6, RPS6KA4, S1K2, STK35, TNK2, UHMK1, ULK1, and WEE1 .

HY-130521

Pomalidomide-amido-PEG3-C2-NH2 Cereblon Ligand-Linker Conjugates 22; E3 ligase Ligand-Linker Conjugates 55	E3 Ligase Ligand-Linker Conjugates	Cancer
Pomalidomide-amido-PEG3-C2-NH2 (Cereblon Ligand-Linker Conjugates 22) is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 3-unit PEG linker used in PROTAC technology .

HY-136194

TL13-22	Anaplastic lymphoma kinase (ALK)	Cancer
TL13-22 is a negative control for TL13-12 (HY-122582) and a potent ALK inhibitor with an IC₅₀ of 0.54 nM. TL13-22 does not degrade ALK in cells .

HY-136195

TL13-110	Anaplastic lymphoma kinase (ALK)	Cancer
TL13-110 is a negative control for TL13-112 (HY-123919) and a potent ALK inhibitor with an IC₅₀ of 0.34 nM. TL13-110 does not degrade ALK in cells .

HY-148063

DB0614	PROTACs AAK1 Aurora Kinase CaMK CDK Ferroptosis Salt-inducible Kinase (SIK) ULK Wee1 LIM Kinase (LIMK)	Others
DB0614 (Example 21) is a bifunctional compound targeted protein degradation of kinases. DB0614 degrades AAK1, AURKA, BMP2K, CAMKK1, CDK16, CML, CDK6, EIF2AK2, FER, GAK, LCK, LIMK2, MAP3KH, MAPK8, MAPK9, NEK9, PLK4, PTK2B, SIK2, STK17A, STK17B, ULK1, ULK3, and WEE1. DB0614 can be used for research of disease or disorder mediated by aberrant kinase activity .

HY-148061

DB1113	PROTACs Bcr-Abl CDK Salt-inducible Kinase (SIK) Cyclin G-associated Kinase (GAK) MAP4K MAPKAPK2 (MK2) Ferroptosis ULK LIM Kinase (LIMK)	Others
DB1113 (Example 24) is a bifunctional compound targeted protein degradation of kinases. DB1113 degrades ABL1, ABL2, BLK, CDK11B, CDK4, CSK, EPHA3, FER, GAK, LIMK1, MAP3K20, MAP4K1, MAP4K2, MAP4K3, MAP4K5, MAPK14, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, NLK, PDIK1L, PTK2B, RIPK1, RPS6KA1, RPS6KA3, SIK2, SIK3, STK35, TNK2, and ULK1. DB1113 can be used for research of disease or disorder mediated by aberrant kinase activity .

Species:	Human (2)
Tag:	Tag Free (1) GST (1)
Source:	Sf9 insect cells (2)

Cat. No.	Compare	Product Name	Species	Source

HY-P701682

	FAK1 Protein, Human (Sf9, GST) PTK2; Focal adhesion kinase 1; FADK 1; Focal adhesion kinase-related nonkinase; FRNK; Protein phosphatase 1 regulatory subunit 71; PPP1R71; Protein-tyrosine kinase 2; p125FAK; pp125FAK	Human	Sf9 insect cells
	FAK1 is a nonreceptor protein tyrosine kinase that coordinates multiple cellular processes. FAK1 Protein, Human (Sf9, GST) is the recombinant human-derived FAK1 protein, expressed by Sf9 insect cells , with N-GST labeled tag. The total length of FAK1 Protein, Human (Sf9, GST) is 1052 a.a., .

HY-P702717

	PTK2B Protein, Human (sf9) PTK2B; PTK2B protein tyrosine kinase 2 beta; FAK2, protein tyrosine kinase 2 beta; protein-tyrosine kinase 2-beta; CADTK; CAKB; PTK; PYK2; RAFTK; FADK 2; CAK-beta; protein kinase B; focal adhesion kinase 2; cell adhesion kinase beta; proline-rich tyrosine kinase 2; calcium-dependent tyrosine kinase; related adhesion focal tyrosine kinase; calcium-regulated non-receptor proline-rich tyrosine kinase; PKB; FAK2; FADK2	Human	Sf9 insect cells


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Cat. No.	Product Name	Application	Reactivity

HY-P80816

Phospho-FAK (Tyr576) Antibody PTK2; FAK; FAK1; Focal adhesion kinase 1; FADK 1; Focal adhesion kinase-related nonkinase; FRNK; Protein phosphatase 1 regulatory subunit 71; PPP1R71; Protein-tyrosine kinase 2; p125FAK; pp125FAK	WB	Human, Mouse
Phospho-FAK (Tyr576) Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 119 kDa, targeting to Phospho-FAK (Tyr576). It can be used for WB assays with tag free, in the background of Human, Mouse.

HY-P80877

PYK2 Antibody (YA682) PTK2B; FAK2; PYK2; RAFTK; Protein-tyrosine kinase 2-beta; Calcium-dependent tyrosine kinase; CADTK; Calcium-regulated non-receptor proline-rich tyrosine kinase; Cell adhesion kinase beta; CAK-beta; CAKB; Focal adhesion kinase 2; FADK 2; Pro	WB, IHC-P	Human
PYK2 Antibody (YA682) is a non-conjugated and Mouse origined monoclonal antibody about 116 kDa, targeting to PYK2 (4B4). It can be used for WB,IHC-P assays with tag free, in the background of Human.

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