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Peptide Inhibitors

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Amyloid-β (24) CGRP Receptor (2) Formyl Peptide Receptor (FPR) (14) Peptide-Drug Conjugates (PDCs) (4) 5-HT Receptor (1) AAK1 (1) ADAMTS (1) ADC Cytotoxin (4) ADC Linker (1) Adrenergic Receptor (3) Akt (4) Amino Acid Derivatives (8) Aminoacyl-tRNA Synthetase (2) Aminopeptidase (6) AMPK (2) Amylin Receptor (3) Anaplastic lymphoma kinase (ALK) (1) Angiotensin Receptor (4) Angiotensin-converting Enzyme (ACE) (14) Annexin A (2) Antibiotic (32) Antibody-Drug Conjugates (ADCs) (3) APC (1) Apelin Receptor (APJ) (3) Apoptosis (74) Arf Family GTPase (1) Arp2/3 Complex (2) Arrestin (1) ATM/ATR (1) Autophagy (14) Bacterial (104) Bcl-2 Family (11) Beta-lactamase (1) Beta-secretase (2) Biochemical Assay Reagents (8) Bombesin Receptor (6) c-Met/HGFR (1) c-Myc (1) Calcium Channel (16) Calmodulin (3) CaMK (11) Carbonic Anhydrase (1) Casein Kinase (1) Caspase (14) Cathepsin (4) CCR (3) CD47 (2) CDK (2) CFTR (1) Checkpoint Kinase (Chk) (3) Chloride Channel (2) Cholecystokinin Receptor (1) Cholinesterase (ChE) (7) CMV (1) Complement System (13) COX (3) CXCR (11) Cytochrome P450 (2) Dengue Virus (4) Deubiquitinase (2) Dipeptidyl Peptidase (5) DNA/RNA Synthesis (8) Dopamine Receptor (2) Drug Derivative (1) Drug Intermediate (1) Drug Metabolite (1) Drug-Linker Conjugates for ADC (11) Dynamin (5) E1/E2/E3 Enzyme (4) EBV (1) EGFR (7) Elastase (4) Endogenous Metabolite (17) Endothelin Receptor (10) Enterovirus (1) Ephrin Receptor (1) Epigenetic Reader Domain (8) ERK (11) Estrogen Receptor/ERR (4) FAAH (1) Factor VIIa (1) Factor Xa (1) FAK (1) FAP (1) Farnesyl Transferase (1) Ferroptosis (3) FGFR (4) Flavivirus (1) Fluorescent Dye (4) Free Fatty Acid Receptor (1) Fungal (14) Furin (2) Gap Junction Protein (6) GCGR (4) GLP Receptor (3) GLUT (2) Glutathione Peroxidase (1) Glycoprotein VI (1) GnRH Receptor (9) GPR35 (1) GSK-3 (4) Guanylate Cyclase (1) HBV (1) HCV (7) HCV Protease (5) HDAC (2) Hexokinase (1) HIF/HIF Prolyl-Hydroxylase (3) Histamine Receptor (3) Histone Demethylase (1) Histone Methyltransferase (15) HIV (21) HIV Protease (3) HPV (1) HSP (3) HSV (1) Huntingtin (1) IFNAR (1) iGluR (8) IKK (1) Influenza Virus (3) Insulin Receptor (5) Integrin (27) Interleukin Related (16) Isotope-Labeled Compounds (6) JAK (1) JNK (12) Kallikrein (3) Keap1-Nrf2 (1) LAG-3 (2) LDLR (1) Legumain (1) Leukotriene Receptor (4) Ligands for E3 Ligase (1) Ligands for Target Protein for PROTAC (1) LIM Kinase (LIMK) (1) mAChR (2) MAP3K (2) MAPKAPK2 (MK2) (6) MARCKS (4) Mas-related G-protein-coupled Receptor (MRGPR) (2) MDM-2/p53 (5) MEK (2) Melanocortin Receptor (2) METTL3 (2) Microtubule/Tubulin (14) Mitochondrial Metabolism (2) Mitophagy (1) Mitosis (1) MMP (7) Monoamine Oxidase (2) Monocarboxylate Transporter (1) mTOR (3) Mucin (1) Myosin (3) N-myristoyltransferase (1) Na+/Ca2+ Exchanger (1) Na+/K+ ATPase (2) nAChR (7) NADPH Oxidase (2) Necroptosis (1) Neprilysin (10) Neurokinin Receptor (8) Neuropeptide S Receptor (1) Neuropeptide Y Receptor (9) Neurotensin Receptor (1) NF-κB (19) NO Synthase (8) NOD-like Receptor (NLR) (4) Notch (3) Nuclear Factor of activated T Cells (NFAT) (5) Opioid Receptor (2) P-glycoprotein (1) P-selectin (3) p38 MAPK (6) p62 (2) PACAP Receptor (3) PAK (2) Parasite (6) PARP (1) PCSK9 (3) PD-1/PD-L1 (15) PDGFR (1) PDK-1 (1) PGE synthase (1) Phosphatase (4) PI3K (5) Piezo Channel (4) Pim (2) PKA (5) PKC (35) PKG (4) Platelet-activating Factor Receptor (PAFR) (1) Polo-like Kinase (PLK) (1) Potassium Channel (24) Prolyl Endopeptidase (PREP) (6) Prostaglandin Receptor (1) PROTACs (2) Protease Activated Receptor (PAR) (19) Proteasome (13) Protein Arginine Deiminase (1) Proton Pump (3) PSMA (1) Pyroptosis (3) Radionuclide-Drug Conjugates (RDCs) (3) Raf (4) Ras (13) Reactive Oxygen Species (10) Reference Standards (2) Renin (3) RIP kinase (1) ROCK (1) ROR (1) SARS-CoV (16) SDCBP (1) Ser/Thr Kinase (1) Ser/Thr Protease (7) SHP2 (2) Sodium Channel (19) Somatostatin Receptor (1) SOS1 (2) Src (15) STAT (8) Tau Protein (1) Telomerase (1) TGF-beta/Smad (6) TGF-β Receptor (2) Thrombin (4) Thymidylate Synthase (1) Thyroid Hormone Receptor (1) Tie (1) TNF Receptor (6) Toll-like Receptor (TLR) (5) Topoisomerase (2) Transglutaminase (1) Transmembrane Glycoprotein (4) TREM receptor (2) Trk Receptor (1) TRP Channel (4) Tyrosinase (1) VEGFR (8) Virus Protease (4) WDR5 (3) Wnt (9) YAP (5) α-synuclein (1) β-catenin (8) γ-secretase (4)
By Research Areas:	Cancer (296) Cardiovascular Disease (125) Endocrinology (38) Infection (176) Inflammation/Immunology (214) Metabolic Disease (75) Neurological Disease (190)
Click Chemistry:	Azide (1) Alkynes (2)
Oligonucleotides:	Aptamers (1)

969

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

705

Peptides

MCE Kits

Inhibitory Antibodies

Natural
Products

Isotope-Labeled Compounds

Click Chemistry

Oligonucleotides

Targets Recommended: Formyl Peptide Receptor (FPR) Connective Peptide Peptide-Drug Conjugates (PDCs) Natriuretic Peptide Receptor (NPR) Serpin RXFP Receptor CGRP Receptor Amyloid-β

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P5960

PTBP1-RNA-binding inhibitor P6 TFA PTBP1 α3-helix derived Peptide P6 TFA	DNA/RNA Synthesis	Others
PTBP1-RNA-binding inhibitor P6 (PTBP1 α3-helix derived peptide P6) TFA is a stapled peptide inhibitor of the splicing factor PTBP1, which inhibits alternative splicing events regulated by PTBP1. PTBP1 binds RNA through its RNA recognition motif .

HY-P10422

Multi-Leu peptide ML-Peptide, Multi-Leucine (ML)-Peptide	Autophagy	Cancer
Multi-Leu peptide (ML-peptide) is a potent inhibitor of PACE4 (K_i=22 nM). Multi-Leu peptide can competitively bind to the active site of PACE4 by simulating the substrate sequence of PACE4, thereby inhibiting its catalytic activity. Multi-Leu peptide can be used to study the specific mechanism of PACE4 in the development of prostate cancer .

HY-P10818

Polyglutamine binding peptide 1	Huntingtin	Neurological Disease
Polyglutamine binding peptide 1 (QBP1) is a peptide inhibitor of polyglutamine (polyQ). Polyglutamine binding peptide 1 inhibits polyQ protein aggregation in vitro and suppresses polyQ-induced cell death in cell culture .

HY-P10950

PD-L1 inhibitory peptide	PD-1/PD-L1	Inflammation/Immunology Cancer
PD-L1 inhibitory peptide is an inhibitor peptide targeting programmed cell death ligand 1 (PD-L1). PD-L1 inhibitory peptide binds to PD-L1, relieving immunosuppression and restoring the antitumor activity of T cells. PD-L1 inhibitory peptide is promising for research of cancers .

HY-P5793

GTx1-15	Sodium Channel Calcium Channel	Neurological Disease
GTx1-15 is an inhibitor cystine knot (ICK) peptide that inhibits the voltage-dependent calcium channel Cav3.1 and the voltage-dependent sodium channels Nav1.3 and Nav1.7 .

HY-P1054

pep2-EVKI YNVYGIEEVKI	PKC	Neurological Disease
pep2-EVKI (YNVYGIEEVKI) is an inhibitor peptide that selectively blocks PICK1 interactions, caused the opposite effects on synaptic AMPAR function to PICK1 expression .

HY-P5818

BDS-II	Sodium Channel	Neurological Disease
BDS-II is a peptide toxin, and is composed of 43 amino acids. BDS-II is a selective Kv3.4 channel inhibitor .

HY-P2043

Cyanopeptolin 954	Ser/Thr Protease	Others
Cyanopeptolin 954 is a sedimentation peptide isolated from the freshwater cyanobacterium Microcystis aeruginosa NIVA Cya 43. Cyanopeptolin 954 inhibits chymosin with an IC₅₀ value of 45 nM .

HY-P10437

VIRIP human α1-AT(353-372)	HIV	Infection
VIRIP (human α1-AT(353-372)) is a HIV-1 inhibitor. VIRIP blocks the entry of HIV-1 by interacting with gp41 fusion peptide. VIRIP can be used for virus research .

HY-P10570

[Nle20] H4 peptide (16−23)	Histone Methyltransferase	Cancer
[Nle20] H4 peptide (16−23) is a peptide with strong inhibitory activity against histone methyltransferase SETD8 (K_d=0.14 μM), which inhibits SETD8's methylation of histone H4 by competing with SETD8's substrate binding site. [Nle20] H4 peptide (16−23) can be used as a lead compound for anticancer therapy .

HY-P5801

Phlo1a μ-TrTx-Phlo1a	Sodium Channel	Neurological Disease
Phlo1a (μ-TrTx-Phlo1a) is a peptide toxin contains 35-amino acid residues. Phlo1b is a selective Nav1.7 inhibitor. Phlo1a has a weak inhibitory effect on Nav1.2 and Nav1.5 .

HY-P5800

Phlo1b μ-TrTx-Phlo1b	Sodium Channel	Neurological Disease
Phlo1b (μ-TrTx-Phlo1b) is a peptide toxin contains 35-amino acid residues. Phlo1b is a selective Nav1.7 inhibitor. Phlo1b has a weak inhibitory effect on Nav1.2 and Nav1.5 .

HY-P3695

VSPPLTLGQLLS	FGFR	Cancer
VSPPLTLGQLLS is a small peptide FGFR3 inhibitor, peptide P3, inhibits FGFR3 phosphorylation. VSPPLTLGQLLS inhibits 9-cisRA-induced tracheal lymphangiogenesis and blocks lymphatic endothelial cell (LEC) proliferation, migration, and tubule formation .

HY-162371

NRPSs-IN-1	Aminoacyl-tRNA Synthetase	Infection
NRPSs-IN-1 (Compound 7) is a cell-penetrating inhibitor of *non-ribosomal peptide* synthetase (NRPSs*). NRPSs-IN-1 K inhibits* gramicidin S synthetase A (GrsA) with a K_d value of 16.6 nM .

HY-P3695A

VSPPLTLGQLLS TFA	FGFR	Cancer
VSPPLTLGQLLS TFA is a small peptide FGFR3 inhibitor, peptide P3, inhibits FGFR3 phosphorylation. VSPPLTLGQLLS TFA inhibits 9-cisRA-induced tracheal lymphangiogenesis and blocks lymphatic endothelial cell (LEC) proliferation, migration, and tubule formation .

HY-P5107

Low molecular weight protamine LMWP	VEGFR	Cancer
Low molecular weight protamine is a cell-penetrating peptide with vascular endothelial growth factor (VEGF) inhibitory activity. Low molecular weight protamine can inhibit tumor growth and is used in cancer research .

HY-P10823

RI-OR2	Amyloid-β	Neurological Disease
RI-OR2, a retro-inverso peptide, is an amyloid-β (Aβ) oligomerization inhibitor. RI-OR2 binds to immobilized β-Amyloid (1-42) (HY-P1363A) monomers and fibrils, with an apparent K_d of 9-12 μM, and also acted as an inhibitor of Aβ(1-42) fibril extension .

HY-P5786

Heteropodatoxin-1	Potassium Channel Sodium Channel	Neurological Disease
Heteropodatoxin-1 (HpTx1), a spider peptide toxin, is a Kv4.2 current inhibitor. Heteropodatoxin-1 also inhibits Nav1.7 and activates Nav1.9 but does not affect Nav1.8 .

HY-P10572

HG1 Toxin	Ser/Thr Protease Potassium Channel	Inflammation/Immunology Endocrinology
HG1 Toxin is a peptide found in the venom of the scorpion Heterometrus fulvipes, which has the activity of inhibiting potassium channel Kv1.3. HG1 Toxin also has the activity of inhibiting trypsin (K_i=107 nM) and can be used in the study of autoimmune diseases .

HY-161079

TDI-8304	Parasite	Infection
TDI-8304, a macrocyclic peptide, is a potent, species selective, and noncovalent Plasmodium falciparum (Pf20S) inhibitor. TDI-8304 shows highly selective for Pf20S over human proteasomes .

HY-P10820

N36Mut(e,g)	HIV	Infection
N36Mut(e,g) is a gp41-targeted HIV fusion peptide inhibitor. N36Mut(e,g) acts by disrupting the homotrimeric coiled-coil of N-terminal helices in the pre-hairpin intermediate to form heterotrimers .

HY-117961

Candoxatrilat UK 73967	Neprilysin	Cardiovascular Disease Endocrinology
Candoxatrilat (UK 73967) is an orally active inhibitor of neutral endopeptidase. By elevating the levels of atrial natriuretic peptides, Candoxatrilat exerts its diuretic and natriuretic effects. Candoxatrilat is utilized in the research of heart failure .

HY-129412

A-74273	Renin	Cardiovascular Disease
A-74273 is an orally active peptide renin inhibitor (IC₅₀=3.1 nM). A-74273 competitively binds to the active site of renin, preventing angiotensinogen from being converted to ANG-I, thereby reducing the level of angiotensin II. A-74273 can be used in the study of diseases such as hypertension .

HY-P10810

QPH-FR	Wnt β-catenin	Cancer
QPH-FR, a quinoa peptide, is a leucine-rich repeat-containing G-protein-coupled receptor 5 (LGR5) inhibitor. QPH-FR competitively suppresses the formation of the LGR5/RSPO1 complex by binding to LGR5. QPH-FR causes RNF43/ZNRF3 to ubiquitinate the FZD receptor, thereby suppressing the Wnt/β-catenin signaling pathway and exerting stemness inhibition .

HY-P10404

PDpep1.3	α-synuclein	Others Neurological Disease
PDpep1.3 is a peptide inhibitor of α-synuclein that disrupts the direct interaction between α-synuclein and CHarged Multivesicular body Protein 2B (CHMP2B). As a result, PDpep1.3 restores the degradation function of endosomes and lysosomes, reduces the protein level and aggregation of α-synuclei, and protects dopaminergic neurons from α-synuclei-mediated degeneration. PDpep1.3 can be used to study neurodegenerative diseases and protein-protein interactions .

HY-117607

Alatrioprilat	Neprilysin Angiotensin-converting Enzyme (ACE)	Cardiovascular Disease
Alatrioprilat is an orally active inhibitor of angiotensin-converting enzyme (ACE) (IC₅₀=19.6 nM; K_i=9.8 nM) and enkephailnase (IC₅₀=6.1 nM; K_i=5.1 nM). Alatrioprilat plays a key role in the metabolism of hormonal peptides through the degradation of nitric oxide and atrial natriuretic factor (ANF). Alatrioprilat can be used in the study of cardiovascular diseases .

HY-P10072A

MK2-IN-5 acetate Hsp25 kinase inhibitor acetate; Mk2 pseudosubstrate acetate	JNK HSP MAPKAPK2 (MK2) p38 MAPK ERK	Others
MK2-IN-5 (Hsp25 kinase inhibitor) acetate is a Mk2 pseudosubstrate (K_i= 8 μM). MK2-IN-5 acetate targets the protein interaction domain in the MAPK pathway. MK2-IN-5 acetate inhibits HSP25 and HSP27 phosphorylation .

HY-P10072

MK2-IN-5 Hsp25 kinase inhibitor; Mk2 pseudosubstrate	ERK JNK p38 MAPK HSP MAPKAPK2 (MK2)	Others
MK2-IN-5 is a Mk2 pseudosubstrate (K_i= 8 μM). MK2-IN-5 targets the protein interaction domain in the MAPK pathway. MK2-IN-5 inhibits HSP25 and HSP27 phosphorylation .

HY-P10485

Glp-Asn-Pro-AMC	Thyroid Hormone Receptor	Neurological Disease
Glp-Asn-Pro-AMC is an inhibitor of thyrotropin-releasing hormone degrading enzyme (TRH-DE) with a K_i value of 0.97 μM .

HY-P3816

PKCε Inhibitor Scramble Peptide	PKC	Others
PKCε Inhibitor Scramble Peptide is a scrambled peptide with identical amino acid composition to PKCε inhibitor peptide.

HY-P4133

*MEK1 Derived Peptide* Inhibitor 1**	ERK MEK	Cancer
MEK1 Derived Peptide Inhibitor 1 is a peptide inhibitor. MEK1 Derived Peptide Inhibitor 1 can inhibit the in vitro activation of ERK2 by MEK1 with an IC₅₀ value of 30 μM. MEK1 Derived Peptide Inhibitor 1 can be used for the research of cell-permeable .

HY-P5388

*Renin inhibitor* peptide,rat**	Renin	Others
Renin inhibitor peptide,rat is a biological active peptide. (A specific rat renin inhibitor.)

HY-P4488

H-Pro-Pro-Gln-OH	Dipeptidyl Peptidase	Others
H-Pro-Pro-Gln-OH is a oligopeptide with excellent dipeptidyl peptidase-IV (DPP-IV) inhibitory activity .

HY-157157

PAD4-IN-3	Protein Arginine Deiminase	Cancer
PAD4-IN-3 (compound 4B) is a PAD4 inhibitor with antitumor activity in vitro and in vivo. PAD4-IN-3 was covalently linked to RGD sequence peptide-modified chitosan (K-CRGDV), resulting in an enhanced oxidative stress-responsive nanoagent. K-CRGDV-PAD4-IN-3 can actively target tumors, inhibit PAD4 activity, block the formation of neutrophil extracellular traps (NETs), and improve the tumor immune microenvironment in response to the tumor microenvironment .

HY-P1190

c-JUN peptide	JNK Apoptosis	Inflammation/Immunology
c-JUN peptide is a cell-permeable c-JUN-JNK interaction inhibitor. c-JUN peptide inhibits serum-induced c-Jun phosphorylation. c-JUN peptide induces apoptosis .

HY-P3199

*PKCβII Peptide* Inhibitor I**	PKC	Inflammation/Immunology
PKCβII Peptide Inhibitor I is a PKCβII inhibitor. PKCβII Peptide Inhibitor I shows cardioprotective effects in rat cardiac Ischemia/reperfusion injury model. PKCβII Peptide Inhibitor I also prevents vascular endothelial dysfunction .

HY-P0301A

*SLLK, Control Peptide* for TSP1 Inhibitor(TFA)**	TGF-β Receptor	Cancer
SLLK, Control Peptide for TSP1 Inhibitor (TFA) is a control peptide for LSKL, which is a Thrombospondin (TSP-1) inhibitor.

HY-103271

*Bax inhibitor* peptide, negative control**	Bcl-2 Family	Cancer
Bax inhibitor peptide, negative control is a inhibitor of Bax. Bax inhibitor peptide, negative control inhibits Bax translocation to mitochondria and Bax-mediated apoptosis in vitro .

HY-P4136

*Myristoyl-MEK1 Derived Peptide* Inhibitor 1**	ERK	Cancer
Myristoyl-MEK1 Derived Peptide Inhibitor 1 is the myristoylated form of the MEK1 Derived Peptide Inhibitor 1 (HY-P4133). Myristoyl-MEK1 Derived Peptide Inhibitor 1 inhibits ERK activation with an IC₅₀ of 10 μM .

HY-P1376

G-Protein antagonist peptide	mAChR Adrenergic Receptor	Endocrinology
G-Protein antagonist peptide is the substance P-related peptide that inhibits binding of G proteins to their receptors. G-Protein antagonist peptide competitively and reversibly inhibits M2 muscarinic receptor activation of G_i or G_o and inhibits G_s activation by β-adrenoceptors.

HY-P5381

gp91 ds-tat	NADPH Oxidase	Others
gp91 ds-tat is a biological active peptide. (NADPH oxidase assembly peptide inhibitor)

HY-P1026

NFAT Inhibitor-1 10+ Cited Publications VIVIT Peptide	Nuclear Factor of activated T Cells (NFAT)	Inflammation/Immunology
NFAT Inhibitor (VIVIT peptide) is a cell-permeable peptide inhibitor of nuclear factor of activated Tcells (NFAT) that selectively inhibits calcineurin-mediated dephosphorylation of NFAT .

HY-P1369

DynaMin inhibitory peptide, myristoylated	Dynamin	Neurological Disease
DynaMin inhibitory peptide, myristoylated is a DynaMin inhibitor to interfere with the binding of amphiphysin with dynamin. DynaMin inhibitory peptide, myristoylated is a membrane-permeant form of the peptide that prevents endocytosis .

HY-P0301

SLLK, Control Peptide for TSP1 Inhibitor	TGF-β Receptor	Cancer
SLLK, Control Peptide for TSP1 Inhibitor is a control peptide for LSKL (leucine-serine-lysine-leucine).

HY-P2534

C-Peptide 2, rat	Insulin Receptor	Metabolic Disease
C-Peptide 2, rat, 31-amino-acid peptide, is a component of proinsulin. C-Peptide 2, rat can inhibit glucose-induced insulin secretion .

HY-P1383A

*Rac1 Inhibitor* F56, control peptide TFA**	Ras	Others
Rac1 Inhibitor F56, control peptide TFA is a peptide containing residues 45-60 of Rac1. Rac1 Inhibitor F56, control peptide TFA contains a Trp ⁵⁶ to Phe ⁵⁶ mutation. Rac1 Inhibitor F56, control peptide TFA has no effect on Rac1 interaction with its guanine nucleotide exchange factors (GEFs) .

HY-P1372

PKC ζ pseudosubstrate	PKC	Others
PKC ζ pseudosubstrate, a PKC ζ inhibitor peptide, can be attached to cell permeabilization vector peptide .

HY-P5720

Peptide 5e	Bacterial	Infection
Peptide 5e is an antimicrobial peptide. Peptide 5e inhibits E. coli, S. aureus, and C. albicans with MIC values of 30, 5, 25 μg/mL respectively .

HY-P2641

Peptide 74	MMP	Cancer
Peptide 74 is a synthetic peptide containing the prodomain sequence of matrix metalloproteinase (MMP). Peptide 74 inhibits the activated form of the 72-kDa type IV collagenase in vitro .

HY-P1369A

DynaMin inhibitory peptide, myristoylated TFA	Dynamin	Neurological Disease
DynaMin inhibitory peptide, myristoylated TFA is a DynaMin inhibitor to interfere with the binding of amphiphysin with dynamin. DynaMin inhibitory peptide, myristoylated TFA is a membrane-permeant form of the peptide that prevents endocytosis .

Cat. No.	Product Name

HY-L110

Cyclic Peptide Library

91 compounds

Cyclic peptides are polypeptide chains taking cyclic ring structure, which exhibit diverse biological activities, such as antibacterial activity, immunosuppressive activity and anti-tumor activity. Cyclic peptides, with the features of good binding affinity, target selectivity and low toxicity, show great success as therapeutics. Multiple cyclic peptides are currently in clinical use, for examples, gramicidin and tyrocidine with bactericidal activity, cyclosporin A with immunosuppressive activity, and vancomycin with antibacterial activity. Furthermore, cyclic peptides usually have the sufficient size and a balanced conformational flexibility/rigidity for binding to flat protein-protein interaction (PPI) interfaces, which have potential to develop PPI drugs.

MCE offers a unique collection of 91 cyclic peptides, all of which have good bioactivities. MCE Cyclic Peptide Library is a powerful tool for drug discovery and PPI inhibitor screening.

Cat. No.	Product Name	Type

HY-100374G

Val-Cit-PAB-MMAE (GMP)	Fluorescent Dye
Val-Cit-PAB-MMAE GMP is a GMP grade Val-Cit-PAB-MMAE (HY-100374). Val-Cit-PAB-MMAE is a agent-linker conjugate for ADC. Val-Cit-PAB-MMAE contains the ADCs linker (peptide Val-Cit-PAB) and a potent tubulin inhibitor MMAE (HY-15162). MMAE a potent mitotic inhibitor by inhibiting tubulin polymerization.

Cat. No.	Product Name	Type

HY-W133898

Tryptone

Microbial Culture

Tryptone is a peptide-rich bacterial culture medium component that can regulate bacterial cell surface proteins and biofilm-related genes. Tryptone promotes the expression and assembly of bacterial adhesion proteins (such as LapA and LapF) by providing peptide substances as structural factors, enhancing cell surface hydrophobicity and intercellular adhesion, thereby stabilizing the biofilm matrix and supporting the maturation and maintenance of bacterial biofilms. The peptide mixture contained in Tryptone can specifically regulate the transcription of bacterial adhesion-related genes (such as activating LapA and inhibiting LapF), affecting the synthesis and localization of biofilm structural proteins .

HY-W012898

Dimethylglyoxime Biacetyl dioxime	Biochemical Assay Reagents
Dimethylglyoxime (Biacetyl dioxime) belongs to the class of oximes and consists of two acetyl groups attached to a nitrogen atom, which in turn is attached to another nitrogen atom through a diimine bond. Dimethylglyoxime is a specific chelator of Ni that inhibits or slows the aggregation of Aβ peptides in vitro .

HY-B2228

Proteinase, Aspergillus oryzae

Biochemical Assay Reagents

Proteinase, Aspergillus oryzae is a serine protease that hydrolyzes peptide bonds in protein substrates, preferring alkaline conditions (optimal pH 10.5). It efficiently degrades casein, poly-L-glutamic acid, and poly-L-lysine, with activity irreversibly inhibited by diisopropylfluorophosphate (DFP) and potato inhibitor. This enzyme catalyzes proteolysis via serine residues in its active site, finding applications in food processing (e.g., soy sauce fermentation), detergents, and leather industries due to its high yield in solid-state fermentation and cost-effective production.

HY-W250308

ε-Poly-L-lysine (MW 3800-4200)

Epsilon-polylysine (MW 3800-4200); ε-Polylysine (MW 3800-4200); ε-PL (MW 3800-4200)

Cell Assay Reagents

Epsilon-polylysine is an antimicrobial peptide that can be produced by bacteria such as Streptomyces. Epsilon-polylysine inhibits the growth of microorganisms such as bacteria, yeasts and molds and is therefore often used as a green food additive and preservative in various food and beverage products. Epsilon-polylysine has a variety of properties, including thermal stability, resistance to acidic conditions, and broad-spectrum antimicrobial activity. Epsilon-polylysine can be loaded on other materials to form nanoparticles or form nanofiber membranes for targeted delivery to exert sustained antibacterial efficacy. Epsilon-polylysine is also used as a liposome stabilizer .

HY-W250308A

ε-Poly-L-lysine (hydrochloride) (MV 2000-5000)

Epsilon-polylysine (hydrochloride) (MV 2000-5000); ε-Polylysine (hydrochloride) (MV 2000-5000); ε-PL (hydrochloride) (MV 2000-5000)

Cell Assay Reagents

ε-Poly-L-lysine hydrochloride (MV 2000-5000) is an antimicrobial peptide that can be produced by bacteria such as Streptomyces. Epsilon-polylysine hydrochloride inhibits the growth of microorganisms such as bacteria, yeasts and molds and is therefore often used as a green food additive and preservative in various food and beverage products. Epsilon-polylysine hydrochloride has a variety of properties, including thermal stability, resistance to acidic conditions, and broad-spectrum antimicrobial activity. Epsilon-polylysine hydrochloride can be loaded on other materials to form nanoparticles or form nanofiber membranes for targeted delivery to exert sustained antibacterial efficacy. Epsilon-polylysine hydrochloride is also used as a liposome stabilizer .

HY-D1056B3

Lipopolysaccharides, from Klebsiella pneumoniae

LPS, from bacterial (Klebsiella pneumoniae)

Carbohydrates

Lipopolysaccharides, from Klebsiella pneumoniae (LPS, from bacterial (Klebsiella pneumoniae)) are lipopolysaccharide endotoxins and TLR4 activators derived from Klebsiella pneumoniae, and are classified as S-type LPS. Lipopolysaccharides, from Klebsiella pneumoniae exhibit a typical three-part structure: O-antigen, core oligosaccharide, and lipid A. Lipopolysaccharides, from Klebsiella pneumoniae may participate in bacterial immune evasion by inhibiting complement-mediated killing and suppressing the host's secretion of antimicrobial peptides, thereby allowing the bacteria to escape immune defenses. Lipopolysaccharides, from Klebsiella pneumoniae possess high viscosity and resistance to serum-mediated killing, which may lead to sepsis. Lipopolysaccharides, from Klebsiella pneumoniae can be used to construct animal models of sepsis .

HY-100374G

Val-Cit-PAB-MMAE (GMP)	Biochemical Assay Reagents
Val-Cit-PAB-MMAE GMP is a GMP grade Val-Cit-PAB-MMAE (HY-100374). Val-Cit-PAB-MMAE is a agent-linker conjugate for ADC. Val-Cit-PAB-MMAE contains the ADCs linker (peptide Val-Cit-PAB) and a potent tubulin inhibitor MMAE (HY-15162). MMAE a potent mitotic inhibitor by inhibiting tubulin polymerization.

Peptide Inhibitors

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

Peptides

MCE Kits

Inhibitory Antibodies

NaturalProducts

Isotope-Labeled Compounds

Click Chemistry

Oligonucleotides

Natural
Products