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Pifithrin-α

" in MedChemExpress (MCE) Product Catalog:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-15484
    Pifithrin-α hydrobromide
    Maximum Cited Publications
    51 Publications Verification

    Pifithrin hydrobromide; PFTα hydrobromide

    		 MDM-2/p53 Aryl Hydrocarbon Receptor Ferroptosis Apoptosis Cancer
    Pifithrin-α hydrobromide is a p53 inhibitor which blocks its transcriptional activity and prevents cells from apoptosis. Pifithrin-α hydrobromide is also an aryl hydrocarbon receptor (AhR) agonist.
    <em>Pifithrin-α</em> hydrobromide
  • HY-123076
    Pifithrin-α, p-Nitro, Cyclic
    3 Publications Verification

    PFN-α

    		 MDM-2/p53 Neurological Disease
    Pifithrin-α, p-Nitro, Cyclic (PFN-α) is cell-permeable and active-form p53 inhibitor. Pifithrin-α, p-Nitro, Cyclic is one order magnitude more active than Pifithrin-α in protecting cortical neurons exposed to Etoposide (ED50=30 nM). Pifithrin-α, p-Nitro, Cyclic behaves as a p53 posttranscriptional activity inhibitor. Pifithrin-α, p-Nitro, Cyclic do not prevent p53 phosphorylation on the S15 residue .
    <em>Pifithrin-α</em>, p-Nitro, Cyclic
  • HY-130437
    p-nitro-Pifithrin-α

    		MDM-2/p53 TGF-β Receptor Caspase Infection Metabolic Disease
    p-nitro-Pifithrin-α, a cell-permeable analog of pifithrin-α, is a potent p53 inhibitor. p-nitro-Pifithrin-α suppresses p53-mediated TGF-β1 expression in HK-2 cells. p-nitro-Pifithrin-α inhibits the activation of caspase-3 by Zika virus (ZIKV) strains. p-nitro-Pifithrin-α attenuates steatosis and liver injury in mice fed a high-fat diet [4]. non-alcoholic fatty liver disease .
    p-nitro-<em>Pifithrin-α</em>
  • HY-16702A
    Pifithrin-β hydrobromide
    10+ Cited Publications

    PFT β hydrobromide; Cyclic Pifithrin-α hydrobromide

    		 MDM-2/p53 Ferroptosis Cancer
    Pifithrin-β hydrobromide (PFT β hydrobromide) is a potent p53 inhibitor with an IC50 of 23 μM.
    <em>Pifithrin</em>-β hydrobromide
  • HY-16702
    Pifithrin-β

    PFT β; Cyclic Pifithrin-α

    		 MDM-2/p53 Cancer
    Pifithrin-β (PFT β) is a potent p53 inhibitor with an IC50 of 23 μM.
    <em>Pifithrin</em>-β

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