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Results for "

Pim-1

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Pim (50) Anaplastic lymphoma kinase (ALK) (1) Apoptosis (13) Autophagy (3) c-Kit (1) Casein Kinase (3) Caspase (1) CDK (6) Checkpoint Kinase (Chk) (1) DAPK (1) DYRK (3) EGFR (1) ERK (1) FLT3 (1) GSK-3 (2) HDAC (1) MELK (2) mTOR (2) PKC (1) RIP kinase (2) Small Interfering RNA (siRNA) (3) Trk Receptor (1) VD/VDR (1)
By Research Areas:	Cancer (51) Cardiovascular Disease (1) Inflammation/Immunology (3)

Inhibitors & Agonists

Peptides

Natural
Products

Recombinant Proteins

Antibodies

Targets Recommended: Pim

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-162006

Pim-1 kinase inhibitor 8	PKC Pim	Cancer
Pim-1 kinase inhibitor 8 (compound 12) is a potent inhibitor of Pim-1 kinase with an IC₅₀ of 14.3 nM. Pim-1 kinase inhibitor 8 has potent cytotoxicity against MCF-7 and HepG2 cells with IC₅₀s of 0.5 and 5.27 μM, respectively. Pim-1 kinase inhibitor 8 can used in study breast cancer ^[1].

HY-147785

Pim-1 kinase inhibitor 2	Pim Apoptosis	Cancer
Pim-1 kinase inhibitor 2 (Compound 13) is a potent inhibitor of Pim-1 kinase. Pim-1 kinase inhibitor 2 induces apoptosis. Pim-1 kinase inhibitor 2 has the potential for the research of cancer diseases ^[1].

HY-150731

Pim-1 kinase inhibitor 3

Pim Cancer

Pim-1 kinase inhibitor 3 (Compound H5) is a potent Pim-1 kinase inhibitor with an IC₅₀ of 35.13 nM ^[1].

Pim-1 kinase inhibitor 3	Pim	Cancer
Pim-1 kinase inhibitor 3 (Compound H5) is a potent *Pim-1* kinase inhibitor with an IC₅₀ of 35.13 nM ^[1].

HY-149996

Pim-1 kinase inhibitor 6	Pim	Cancer
Pim-1 kinase inhibitor 6 (Compound 4d) is a potent Pim-1 kinase inhibitor with IC₅₀ value of 0.46 μM, and has significant cytotoxic effect on cancer cells ^[1].

HY-163119

Pim-1 kinase inhibitor 9	Pim	Cancer
Pim-1 kinase inhibitor 9 (compound 8b) is a selective inhibitor against Pim-1 kinase with IC₅₀ value of 0.24 µM. Pim-1 kinase inhibitor 9 inhibits cell cycle of T47D at S phase. Pim-1 kinase inhibitor 9 reveals antitumor activity ^[1].

HY-143295

Pim-1 kinase inhibitor 1	Pim Apoptosis	Cancer
Pim-1 kinase inhibitor 1 is a *Pim-1* kinase inhibitor with an IC₅₀ of 0.11 μM for Pim-1 kinase. Pim-1 kinase inhibitor 1 shows anticancer activity to several cancer cell lines by promotes cell apoptosis. Pim-1 kinase inhibitor 1 can be used for the research of cancer ^[1].

HY-149976

Pim-1 kinase inhibitor 4	Pim	Cancer
Pim-1 kinase inhibitor 4 (Compound 10f) is a Pim-1 kinase inhibitor (IC₅₀: 17.01 nM). Pim-1 kinase inhibitor 4 also has antioxidant activity and inhibits DPPH. Pim-1 kinase inhibitor 4 induces apoptosis in PC-3 cell, and inhibits PC-3 cell growth with an IC₅₀ of 16 nM. Pim-1 kinase inhibitor 4 can be used for research of prostate cancer ^[1].

HY-162059

Pim-1 kinase inhibitor 10	Pim Apoptosis Caspase	Cancer
Pim-1 kinase inhibitor 10 (compound 13a) is a both competitive and non-competitive inhibitor of PIM-1/2 kinase. Pim-1 kinase inhibitor 10 can induce cell apoptosis and exhibits anticancer activity. Pim-1 kinase inhibitor 10 also induces caspase 3/7 activation ^[1].

HY-149995

Pim-1 kinase inhibitor 5	Pim	Cancer
Pim-1 kinase inhibitor 5 (Compound 4c) is a Pim-1 kinase inhibitor (IC₅₀: 0.61 μM). Pim-1 kinase inhibitor 5 shows cytotoxicity against cancer cells, with IC₅₀s of 6.95-20.19 μM for HepG2, MCF-7, PC3, and HCT-116 cells ^[1].

HY-RS10547

PIM1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
PIM1 Human Pre-designed siRNA Set A contains three designed siRNAs for PIM1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

PIM1 Human Pre-designed siRNA Set A PIM1 Human Pre-designed siRNA Set A

HY-RS10548

Pim1 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Pim1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Pim1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Pim1 Mouse Pre-designed siRNA Set A Pim1 Mouse Pre-designed siRNA Set A

HY-RS10549

Pim1 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Pim1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Pim1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Pim1 Rat Pre-designed siRNA Set A Pim1 Rat Pre-designed siRNA Set A

HY-143897

PIM1-IN-3	Pim Apoptosis	Cancer
PIM1-IN-3 (Compound HL8) is a potent inhibitor of *PIM1. PIM1-IN-3 shows selective inhibition for the PIM-1* enzyme. PIM1-IN-3 induces apoptosis efficiently in Colo320 cells. PIM1-IN-3 has the potential for the research of cancer diseases ^[1].

HY-108605

PIM1-IN-2	Pim	Cancer
PIM1-IN-2 is a potent and ATP competitive *Pim-1* inhibitor with a K_i of 91 nM. PIM1-IN-2 targets the ATP-binding kinase hinge region not by forming classical hydrogen bonds ^[1].

HY-143898

PIM1-IN-4	Pim	Cancer
PIM1-IN-4 (Compound 8) is a potent inhibitor of *PIM1. PIM1-IN-4 reveals strong inhibition of five other enzymes, i.e., SGK-1, PKA, CaMK-1, GSK3β, and MSK1. PIM1*-IN-4 has the potential for the research of cancer diseases ^[1].

HY-111552

PIM1-IN-1	Pim	Cancer
PIM1-IN-1 is a potent and highly selective *PIM1/3* inhibitor, with IC₅₀s of 7, 5530 and 70 nM for PIM1, PIM2, and PIM3, respectively, inhibits the phosphorylation of BAD, a downstream target of PIM, with an EC₅₀ of 262 nM. PIM1-IN-1 shows no obvious effect on FLT3 or hERG binding. Antiproliferative and anti-cancer activity ^[1].

HY-147921

PIM1-IN-7	Pim	Cancer
PIM1-IN-7 (compound 6c) is a potent *PIM-1* inhibitor, with an IC₅₀ of 0.67 μM. PIM1-IN-7 shows the high cytotoxicity activity against HCT-116 and MCF-7 cells, with IC₅₀ values of 42.9 and 7.68 μM, respectively ^[1].

HY-147920

PIM1-IN-6	Pim	Cancer
PIM1-IN-6 (compound 5h) is a potent *PIM-1* inhibitor, with an IC₅₀ of 0.60 μM. PIM1-IN-6 shows the high cytotoxicity activity against HCT-116 and MCF-7 cells, with IC₅₀ values of 1.51 and 15.2 μM, respectively ^[1].

HY-157404

Pim-1/2 kinase inhibitor 2	Pim	Cancer
Pim-1/2 kinase inhibitor 2 (compound 5b) is a competitive *PIM-1* and PIM-2 kinase inhibitor with IC₅₀s of 1.31 μM and 0.67 μM, respectively. Pim-1/2 kinase inhibitor 2 shows in-vitro low cytotoxicity against normal human lung fibroblast Wi-38 cell line and potent in-vitro anticancer activity against myeloid leukaemia (NFS-60), liver (HepG-2), prostate (PC-3), and colon (Caco-2) cancer cell lines ^[1].

HY-10371

Pim1/AKK1-IN-1 4 Publications Verification LKB1/AAK1 dual inhibitor	Pim	Cancer
Pim1/AKK1-IN-1 is a potent multi-kinase inhibitor with K_d values of 35 nM/53 nM/75 nM/380 nM for *Pim1/AKK1/MST2/LKB1* respectively, and also inhibits MPSK1 and TNIK.

HY-143233

PIM-1/HDAC-IN-1	Pim HDAC Apoptosis	Cancer
PIM-1/HDAC-IN-1 (compound 4d) is a *PIM-1* inhibitor, with an IC₅₀ of 343.87 nM. PIM-1/HDAC-IN-1 has strong inhibitory activity and selectivity against HDAC 1 and HDAC 6, with IC₅₀ values of 63.65 and 62.39 nM, respectively. PIM-1/HDAC-IN-1 exhibits apoptosis inducing potential in MCF-7 cell lines. PIM-1/HDAC-IN-1 shows pre-G1 apoptosis and cell cycle arrest at G2/M phase ^[1].

HY-101947

SMI-16a 3 Publications Verification Pim1/2 Kinase Inhibitor VI	Pim	Cancer
SMI-16a is a selective *Pim* kinase inhibitor with IC₅₀ values of 0.15, 0.02 and 48 μM for Pim1, Pim2 and PC3 cells, respectively.

HY-W412264

Pim-1/2 kinase inhibitor 1	Pim	Cancer
Pim-1/2 kinase inhibitor 1 is an orally active pim-1/2 kinase inhibitor. Pim-1/2 kinase inhibitor 1 blocks the ability of Pim kinases to phosphorylate peptides, and inhibits the pim protein kinase directed phosphorylation of *4E-BP1* and p27 ^Kip1. Pim-1/2 kinase inhibitor 1 can be used in study of cancer, especially prostate cancer ^[1].

HY-18086

*TCS PIM-1* 1** 3 Publications Verification SC 204330	Pim	Cancer
TCS PIM-1 1 (SC 204330) is a potent, selective and ATP-competitive *Pim-1* kianse inhibitor with an IC₅₀ of 50 nM, displays good selectivity over Pim-2 and MEK1/MEK2 (IC₅₀s >20000 nM) ^[1].

HY-16576A

SMI-4a TCS-Pim-1-4a	Pim	Cancer
SMI-4a (TCS-PIM-1-4a) is a poten, selective, cell-permeable and ATP-competitive *Pim-1* inhibitor with an IC₅₀ of 24 μM and a K_i of 0.6 μM. SMI-4a also inhibits *Pim-2* (IC₅₀ of 100 μM), and does not significantly inhibit the other serine/threonine- or tyrosine-kinases. SMI-4a has anticancer activity ^[1].

HY-142696

*CDK6/PIM1-IN-1*	CDK Pim Apoptosis	Cancer
CDK6/PIM1-IN-1 is a potent and balanced dual *CDK6/PIM1* inhibitor with IC₅₀ values of 39 and 88 nM, respectively. CDK6/PIM1-IN-1 inhibits CDK4 (IC₅₀=3.6 nM). CDK6/PIM1-IN-1 significantly inhibits acute myeloid leukemia (AML) cell proliferation, arrest cell cycle at the G1 phase, and promote cell apoptosis. CDK6/PIM1-IN-1 exhibits potent anti-AML activity ^[1].

HY-135816

*CK2/PIM1-IN-1*	Casein Kinase Pim	Inflammation/Immunology Cancer
CK2/PIM1-IN-1 is an inhibitor of CK2 and *PIM1, with IC₅₀s of 3.787 μM and 4.327 μM for CK2 and PIM1, respectively. CK2/PIM1*-IN-1 is developed for the research of proliferative disorders such as cancer, as well as other kinase-associated conditions including inflammation, pain, vascular disorders, pathogenic infections and certain immunological disorders ^[1].

HY-155717

NDBM	Autophagy Pim	Cancer
NDBM is a probe and binds to tumor-specific Pim-1 kinase, releases strong fluorescence, and produces cytotoxicity, thus achieving cell screening and killing effects. NDBM can specifically target lysosomes and sensitively respond to pH. NDBM can be used to track the pH changes in the intracellular environment under conditions of autophagy and external stimulation ^[1].

HY-N1950

Hispidulin 2 Publications Verification Dinatin	Pim	Cancer
Hispidulin is a natural flavone with a broad spectrum of biological activities. Hispidulin is a Pim-1 inhibitor with an IC₅₀ of 2.71 μM.

HY-101126

TP-3654

3 Publications Verification

Pim Cancer

TP-3654 is a second-generation Pim kinase inhibitor with K_i values of 5 and 42 nM for Pim-1 and Pim-3, respectively.

TP-3654 3 Publications Verification	Pim	Cancer
TP-3654 is a second-generation *Pim* kinase inhibitor with K_i values of 5 and 42 nM for Pim-1 and Pim-3, respectively.

HY-13287

SGI-1776 free base Maximum Cited Publications 8 Publications Verification	Pim Autophagy Apoptosis	Cancer
SGI-1776 free base is an inhibitor of *Pim* kinases, with IC₅₀s of 7 nM, 363 nM, and 69 nM for Pim-1, -2 and -3, respectively.

HY-N4149

Quercetagetin 3 Publications Verification 6-Hydroxyquercetin	Pim	Inflammation/Immunology Cancer
Quercetagetin (6-Hydroxyquercetin) is a flavonoid ^[1]. Quercetagetin is a moderately potent and selective, cell-permeable *pim-1* kinase inhibitor (IC₅₀, 0.34 μM) . Anti-inflammatory and anticancer properties.

HY-13287A

SGI-1776	Pim Apoptosis Autophagy	Inflammation/Immunology
SGI-1776 is an inhibitor of Pim kinases, with IC₅₀s of 7 nM, 363 nM, and 69 nM for Pim-1, Pim-2 and Pim-3, respectively ^[1] .

HY-N1950R

Hispidulin (Standard) Dinatin (Standard)	Pim	Cancer
Hispidulin (Standard) is the analytical standard of Hispidulin. This product is intended for research and analytical applications. Hispidulin is a natural flavone with a broad spectrum of biological activities. Hispidulin is a Pim-1 inhibitor with an IC₅₀ of 2.71 μM.

HY-18095

CX-6258

Pim Cancer

CX-6258 is a potent and kinase selective pan-Pim kinases inhibitor, with IC₅₀s of 5 nM, 25 nM and 16 nM for Pim-1, Pim-2 and Pim-3, respectively ^[1].

CX-6258	Pim	Cancer
CX-6258 is a potent and kinase selective *pan-Pim* kinases inhibitor, with IC₅₀*s of 5 nM, 25 nM and 16 nM for Pim-1, Pim-2 and Pim*-3, respectively ^[1].

HY-18095A

CX-6258 hydrochloride hydrate	Pim	Cancer
CX-6258 hydrochloride hydrate is a potent and kinase selective *pan-Pim* kinases inhibitor, with IC₅₀*s of 5 nM, 25 nM and 16 nM for Pim-1, Pim-2 and Pim*-3, respectively ^[1].

HY-18095B

CX-6258 hydrochloride	Pim	Cancer
CX-6258 hydrochloride is a potent and kinase selective *pan-Pim* kinases inhibitor, with IC₅₀*s of 5 nM, 25 nM and 16 nM for Pim-1, Pim-2 and Pim*-3, respectively ^[1].

HY-12929

NSC756093 SU093
NSC756093 is a potent inhibitor of the GBP1:PIM1 interaction. NSC756093 can potentially revert resistance to paclitaxel. NSC756093 can be used for ovarian cancer research ^[1].

HY-P1404

R8-T198wt

Pim Cancer

R8-T198wt is a cell-permeable carboxyl-terminal p27 ^Kip1 peptide exhibits anti-tumor activity by inhibiting Pim-1 kinase ^[1].
HY-101783

GNE-955

Pim Cancer

GNE-955 is a potent and orally active pan Pim kinase inhibitor with K_is of 0.018, 0.11, 0.08 nM for Pim1, Pim2, Pim3, respectively.

R8-T198wt	Pim	Cancer
R8-T198wt is a cell-permeable carboxyl-terminal p27 ^Kip1 peptide exhibits anti-tumor activity by inhibiting Pim-1 kinase ^[1].

GNE-955	Pim	Cancer
GNE-955 is a potent and orally active pan Pim kinase inhibitor with K_is of 0.018, 0.11, 0.08 nM for Pim1, Pim2, Pim3, respectively.

HY-15260

XL413 BMS-863233	CDK	Cancer
XL413 is a potent, selective and ATP competitive inhibitor of Cdc7, with an IC₅₀ of 3.4 nM, and also shows potent effect with IC₅₀s of 215, 42 nM on CK2, PIM1, respectively, and an EC₅₀ of 118 nM on pMCM.

HY-15260A

XL413 monohydrochloride 4 Publications Verification BMS-863233 monohydrochloride	CDK	Cancer
XL413 (BMS-863233) hydrochloride is a potent, selective and ATP competitive inhibitor of Cdc7, with an IC₅₀ of 3.4 nM, and also shows potent effect with IC₅₀s of 215, 42 nM on CK2, PIM1, respectively, and an EC₅₀ of 118 nM on pMCM.

HY-120758

SEL24-B489	Pim FLT3 Apoptosis	Cancer
SEL24-B489 is a potent, type I, orally active, dual *PIM* and FLT3-ITD inhibitor, with K_d values of 2 nM for PIM1, 2 nM for PIM2 and 3 nM for PIM3, respectively ^[1].

HY-12830

M-110	Pim	Cancer
M-110 is a highly selective, ATP-competitive inhibitor of PIM kinases with a preference for *PIM-3* (IC₅₀=47 nM). M-110 inhibits PIM-1 and PIM-2 with similar IC₅₀s of 2.5 μM. M-110 inhibits the proliferation of prostate cancer cell lines with IC₅₀s of 0.6 to 0.9 μM ^[1].

HY-123983

HS56	Pim DAPK	Cardiovascular Disease
HS56 is an ATP-competitive dual *Pim/DAPK3* inhibitor with K_i values of 0.26, 0.208, 2.94, and ＞100 μM for DAPK3, Pim-3, Pim-1, and Pim-2, respectively. HS56 inhibits LC20 phosphorylation and smooth muscle contraction. HS56 decreases blood pressure in spontaneously hypertensive mice. HS56 can be used in research of hypertension ^[1].

HY-16976

GDC-0339 2 Publications Verification	Pim	Cancer
GDC-0339 is a potent, orally bioavailable and well tolerated *pan-Pim* kinase inhibitor, with K_i*s of 0.03 nM, 0.1 nM and 0.02 nM for Pim1, Pim2 and Pim*3, respectively. GDC-0339 is discovered as a potential treatment of multiple myeloma ^[1] .

HY-19322B

PIM-447 dihydrochloride 3 Publications Verification LGH447 dihydrochloride	Pim Apoptosis	Cancer
PIM447 dihydrochloride (LGH447 dihydrochloride) is a potent, orally available, and selective pan-PIM kinase inhibitor, with K_i values of 6, 18, and 9 pM for PIM1, PIM2, and PIM3, respectively. PIM447 dihydrochloride displays dual antimyeloma and bone-protective effects. PIM447 dihydrochloride induces apoptosis ^[1] .

HY-19322

PIM447 3 Publications Verification LGH447
PIM447 (LGH447) is a potent, orally available, and selective pan-PIM kinase inhibitor, with K_i values of 6, 18, and 9 pM for PIM1, PIM2, and PIM3, respectively. PIM447 displays dual antimyeloma and bone-protective effects. PIM447 induces apoptosis ^[1] .

HY-101870B

Uzansertib phosphate INCB053914 phosphate	Pim	Cancer
Uzansertib (INCB053914) phosphate is an orally active, ATP-competitive pan-PIM kinase inhibitor with IC₅₀s of 0.24 nM, 30 nM, 0.12 nM for PIM1, PIM2, PIM3, respectively. Uzansertib phosphate has broad anti-proliferative activity against a variety of hematologic tumor cell lines ^[1].

HY-101870

Uzansertib INCB053914	Pim	Cancer
Uzansertib (INCB053914) is an orally active, ATP-competitive pan-PIM kinase inhibitor with IC₅₀s of 0.24 nM, 30 nM, 0.12 nM for PIM1, PIM2, PIM3, respectively. Uzansertib has broad anti-proliferative activity against a variety of hematologic tumor cell lines ^[1].

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