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R-406

" in MedChemExpress (MCE) Product Catalog:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-12067
    R406
    Maximum Cited Publications
    22 Publications Verification

    		 Syk FLT3 Apoptosis Inflammation/Immunology Cancer
    R406 is an orally available and competitive Syk/FLT3 inhibitor for ATP binding with a Ki of 30 nM, potently inhibits Syk kinase activity in vitro with an IC50 of 41 nM, measured at an ATP concentration corresponding to its Km value. R406 reduces immune complex-mediated inflammation . R406 also inhibits Lyn (IC50=63 nM) and Lck (IC50=37 nM) .
    <em>R406</em>
  • HY-11108
    R406 free base
    Maximum Cited Publications
    22 Publications Verification

    		 Syk FLT3 Apoptosis Inflammation/Immunology Cancer
    R406 free base is an orally available and competitive Syk/FLT3 inhibitor for ATP binding with a Ki of 30 nM, potently inhibits Syk kinase activity in vitro with an IC50 of 41 nM, measured at an ATP concentration corresponding to its Km value. R406 free base reduces immune complex-mediated inflammation . R406 free base also inhibits Lyn (IC50=63 nM) and Lck (IC50=37 nM) .
    <em>R406</em> free base
  • HY-13038A
    Fostamatinib
    5+ Cited Publications

    R788

    		 Syk FLT3 Inflammation/Immunology Cancer
    Fostamatinib (R788) is the oral proagent of the active compound R406 . R406 is an orally available and competitive Syk/FLT3 inhibitor with a Ki of 30 nM and an IC50 of 41 nM . R406 also inhibits Lyn (IC50=63 nM) and Lck (IC50=37 nM) .
    Fostamatinib
  • HY-13038
    Fostamatinib Disodium
    5+ Cited Publications

    R788(Disodium)

    		 Syk FLT3 Inflammation/Immunology Cancer
    Fostamatinib Disodium (R788 Disodium) is the oral proagent of the active compound R406 . R406 is an orally available and competitive Syk/FLT3 inhibitor with a Ki of 30 nM and an IC50 of 41 nM . R406 also inhibits Lyn (IC50=63 nM) and Lck (IC50=37 nM) .
    Fostamatinib Disodium
  • HY-13038B
    Fostamatinib disodium hexahydrate
    5+ Cited Publications

    R788 disodium hexahydrate

    		 Syk FLT3 Inflammation/Immunology Cancer
    Fostamatinib (R788) disodium hexahydrate is the oral proagent of the active compound R406 . R406 is an orally available and competitive Syk/FLT3 inhibitor with a Ki of 30 nM and an IC50 of 41 nM . R406 also inhibits Lyn (IC50=63 nM) and Lck (IC50=37 nM) .
    Fostamatinib disodium hexahydrate

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