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Results for "

RAR-α

" in MedChemExpress (MCE) Product Catalog:

By Targets:	RAR/RXR (29) Apoptosis (7) Autophagy (13) Isotope-Labeled Compounds (1) Thyroid Hormone Receptor (1) TRP Channel (1) VD/VDR (1)
By Research Areas:	Cancer (22) Endocrinology (3) Infection (1) Inflammation/Immunology (6) Metabolic Disease (1) Neurological Disease (6)

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Isotope-Labeled Compounds

Targets Recommended: RAR/RXR ROR

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-107397

Ch55 2 Publications Verification	RAR/RXR	Cancer
Ch55 is a potent synthetic retinoid. Ch55 binds to *RAR-α* and RAR-β receptors with high affinity. Ch55 displays low affinity for cellular retinoic acid binding protein (CRABP). Ch55 is a potent inducer of the differentiation of HL60 cells with an EC₅₀ of 200 nM. Ch55 can be used for cancer research .

HY-153122A

YCT529

RAR/RXR Endocrinology

YCT529 is a potent, selective and orally active RAR-α inhibitor .

YCT529	RAR/RXR	Endocrinology
YCT529 is a potent, selective and orally active *RAR-α* inhibitor .

HY-14653

Amsilarotene TAC-101; Am 555S	RAR/RXR Apoptosis	Cancer
Amsilarotene (TAC-101; Am 555S), an orally active synthetic retinoid, has selective affinity for retinoic acid receptor α (RAR-α) binding with K_i of 2.4, 400 nM for RAR-α and RAR-β. Amsilarotene induces the apoptotic of human gastric cancer, hepatocellular carcinoma and ovarian carcinoma cells. Amsilarotene can be used for the research of cancer .

HY-156280

RARα antagonist 1

RAR/RXR Endocrinology

RARα antagonist 1 (compound 21) is an orally active and selective retinoic acid receptor α(RARα) antagonist, with the IC₅₀ of 4.6nM .
HY-153122

YCT529 free acid

RAR/RXR Endocrinology

YCT529 free acid is a potent, selective and orally active RAR-α inhibitor .
HY-100273

AGN 194078

AGN 194078 is a selective RARα agonist with a K_d and EC₅₀ of 3 and 112 nM, respectively.

RARα antagonist 1	RAR/RXR	Endocrinology
RARα antagonist 1 (compound 21) is an orally active and selective retinoic acid receptor α(RARα) antagonist, with the IC₅₀ of 4.6nM .

YCT529 free acid	RAR/RXR	Endocrinology
YCT529 free acid is a potent, selective and orally active *RAR-α* inhibitor .

AGN 194078
AGN 194078 is a selective *RARα* agonist with a K_d and EC₅₀ of 3 and 112 nM, respectively.

HY-10475

AM580 Maximum Cited Publications 9 Publications Verification CD336; NSC608001; Ro 40-6055	RAR/RXR Autophagy	Cancer
AM580 is a selective *RARα* agonist with IC₅₀ and EC₅₀ of 8 nM and 0.36 nM, respectively.

HY-107395

BMS 753

RAR/RXR Inflammation/Immunology

BMS 753 is an isotype-selective retinoic acid receptor α (RARα) agonist, with a K_i of 2 nM .

BMS 753	RAR/RXR	Inflammation/Immunology
BMS 753 is an isotype-selective retinoic acid receptor α (RARα) agonist, with a K_i of 2 nM .

HY-116248

Ro 41-5253	RAR/RXR Apoptosis	Cancer
Ro 41-5253 is an orally active selective retinoic acid receptor alpha (RARα) antagonist. Ro 41-5253 can bind RARα without inducing transcription or affecting RAR/RXR heterodimerization and DNA binding. Ro 41-5253 can inhibit cancer cell proliferation and induce apoptosis, has antitumor activity .

HY-14652

Tamibarotene Maximum Cited Publications 9 Publications Verification Am 80	RAR/RXR Autophagy Apoptosis	Cancer
Tamibarotene is an orally active retinoic acid receptor α (RARα) agonist, showing high selectivity over RARγ.

HY-107218

11-Hydroxysugiol

RAR/RXR VD/VDR Infection

11-Hydroxysugiol regulates the SUMOylation of intracellular receptors by modulating RARα and vitamin D₃ receptor (VDR) .
HY-16683

AGN 205728

RAR/RXR Autophagy Cancer

AGN 205728 is a potent and selective RARγ antagonist with Ki/IC95 values of 3 nM/ 0.6 nM; no inhibiton on RARα and RARβ.

11-Hydroxysugiol	RAR/RXR VD/VDR	Infection
11-Hydroxysugiol regulates the SUMOylation of intracellular receptors by modulating *RARα* and vitamin D₃ receptor (VDR) .

AGN 205728	RAR/RXR Autophagy	Cancer
AGN 205728 is a potent and selective RARγ antagonist with Ki/IC95 values of 3 nM/ 0.6 nM; no inhibiton on RARα and RARβ.

HY-16682

AGN 196996 2 Publications Verification	RAR/RXR Autophagy	Cancer
AGN 196996 is a potent and selective RARα antagonist with Ki value of 2 nM; little binding affinity for RARβ(Ki=1087 nM) and RARγ(Ki=8523 nM).

HY-101106

AR7 5 Publications Verification	RAR/RXR	Neurological Disease Cancer
AR7 is an atypical RARA/RARα (retinoic acid receptor, alpha) antagonist. AR7 specifically activates chaperone-mediated-autophagy (CMA) activity without affecting macroautophagy .

HY-108531

ER 50891	RAR/RXR	Cancer
ER-50891 is a potent antagonist of retinoic acid receptor α(RARα). ER-50891 significantly attenuates ATRA's inhibitive effects on BMP 2-induced osteoblastogenesis .

HY-108531A

ER 50891 quarterhydrate	RAR/RXR	Cancer
ER 50891 quarterhydrate is a potent antagonist of retinoic acid receptor α(RARα). ER 50891 quarterhydrate significantly attenuates ATRA's inhibitive effects on BMP 2-induced osteoblastogenesis .

HY-16684

AGN-195183 IRX-5183; VTP-195183; NRX-195183	RAR/RXR Autophagy	Cancer
AGN-195183 (IRX-5183) is a potent and selective agonist of *RARα* (K_d=3 nM) with improved binding selectivity relative to AGN 193836. AGN-195183 has no activity on RARβ/γ.

HY-119518

BMS641 BMS-209641	RAR/RXR	Cancer
BMS641 (BMS-209641) is a selective RARβ agonist. BMS641 has a higher affinity for RARβ (K_d, 2.5 nM) that is 100 times higher than that for RARα (K_d, 225 nM) or RARγ (K_d, 223 nM) .

HY-U00449S

AGN 193109-d7	Isotope-Labeled Compounds RAR/RXR Autophagy	Cancer
AGN 193109-d₇ is the deuterium labeled AGN 193109. AGN 193109 is a retinoid analog, and acts as a specific and highly effective antagonist of retinoic acid receptors (RARs), with Kds of 2 nM, 2 nM, and 3 nM for RARα, RARβ, and RARγ, respectively.

HY-108530

MM11253	RAR/RXR	Cancer
MM11253 is a potent and selective RARγ antagonist with an IC₅₀ of 44 nM. MM11253 has lower inhibition of RARα, RARβ and RXRα. MM11253 blocks the growth inhibitory effects of RARγ-selective agonists .

HY-10475G

AM580 CD336; NSC608001; Ro 40-6055	RAR/RXR	Cancer
AM580 (CD336) (GMP) is AM580 (HY-10475) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. AM580 is a selective RARα agonist .

HY-100256

Trifarotene CD5789	RAR/RXR Autophagy	Inflammation/Immunology
Trifarotene (CD5789) is a potent and selective RARγ agonist. Trifarotene (CD5789) shows ∼65-fold and ∼16-fold selectivitiy for the RARγ (EC₅₀=7.7 nM) over *RARα* (EC₅₀=500 nM) and RARβ (EC₅₀=125 nM), respectively .

HY-U00449

AGN 193109 4 Publications Verification	RAR/RXR Autophagy	Cancer
AGN 193109 is a retinoid analog, and acts as a specific and highly effective antagonist of retinoic acid receptors (RARs), with K_ds of 2 nM, 2 nM, and 3 nM for *RARα, RARβ, and RAR*γ, respectively. AGN 193109 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-16681

AGN 194310 5 Publications Verification VTP-194310	RAR/RXR Autophagy	Cancer
AGN 194310 (VTP-194310) is a high affinity, potent and selective retinioic acid receptors (RARs) pan-antagonist with K_d values of 3 nM, 2 nM, 5 nM for *RARα, RARβ, RAR*γ, respectively . AGN 194310 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-B0091

Adapalene 4 Publications Verification CD271	RAR/RXR Autophagy Apoptosis	Neurological Disease Inflammation/Immunology Cancer
Adapalene (CD271), a third-generation synthetic retinoid, is widely used for the research of acne. Adapalene is a potent *RAR* agonist, with AC₅₀s of 2.3 nM, 9.3 nM, and 22 nM for RARβ, RARγ, *RARα, respectively. Adapalene also inhibits the enzymatic activity of GOT1* in a non-competitive manner. Adapalene exhibits anti-tumor activity .

HY-B0091A

Adapalene sodium salt CD 271 sodium salt	RAR/RXR Autophagy Apoptosis	Neurological Disease Inflammation/Immunology Cancer
Adapalene (CD271) sodium salt, a third-generation synthetic retinoid, is widely used for the research of acne. Adapalene sodium salt is a potent *RAR* agonist, with AC₅₀s of 2.3 nM, 9.3 nM, and 22 nM for RARβ, RARγ, *RARα, respectively. Adapalene sodium salt also inhibits the enzymatic activity of GOT1* in a non-competitive manner. Adapalene sodium salt exhibits anti-tumor activity .

HY-107436

LE135 1 Publications Verification	RAR/RXR TRP Channel	Neurological Disease Cancer
LE135 is a potent RAR antagonist that binds selectively to *RARα* (K_i of 1.4 μM) and RARβ (K_i of 220 nM), and has a higher affinity to RARβ. LE135 is highly selective over RARγ, RXRα, RXRβ and RXRγ. LE135 is also a potent TRPV1 and TRPA1 receptors activator with EC₅₀s of 2.5 μM and 20 μM, respectively .

HY-B0091S

Adapalene-d3	RAR/RXR Autophagy Apoptosis	Neurological Disease Inflammation/Immunology Cancer
Adapalene-d₃ is the deuterium labeled Adapalene. Adapalene (CD271), a third-generation synthetic retinoid, is widely used for the research of acne. Adapalene is a potent RAR agonist, with AC50s of 2.3 nM, 9.3 nM, and 22 nM for RARβ, RARγ, RARα, respectively. Adapalene also inhibits the enzymatic activity of GOT1 in a non-competitive manner. Adapalene exhibits anti-tumor activity[1][2][3].

HY-105689

AGN 192870	RAR/RXR	Others
AGN 192870 is a *RAR* neutral antagonist with K_ds of 147, 33, and 42 nM for RARα, RARβ, and RARγ, respectively. AGN 192870 shows IC₅₀s of 87 and 32 nM for RARαand RARγ, respectively. AGN 192870 shows RARβ partial agonism . AGN 192870 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-B0091R

Adapalene (Standard) CD271 (Standard)	RAR/RXR Autophagy Apoptosis	Neurological Disease Inflammation/Immunology Cancer
Adapalene (Standard) is the analytical standard of Adapalene. This product is intended for research and analytical applications. Adapalene (CD271), a third-generation synthetic retinoid, is widely used for the research of acne. Adapalene is a potent *RAR* agonist, with AC₅₀s of 2.3 nM, 9.3 nM, and 22 nM for RARβ, RARγ, *RARα, respectively. Adapalene also inhibits the enzymatic activity of GOT1* in a non-competitive manner. Adapalene exhibits anti-tumor activity .

HY-127024

Thyroid hormone receptor antagonist (1-850)	Thyroid Hormone Receptor	Metabolic Disease
Thyroid hormone receptor antagonist (1-850) is a competitive, selective and high-affinity thyroid hormone receptor (TR) antagonist with an IC₅₀ of 1.5 μM for antagonizing the effect of T3 on TR. Thyroid hormone receptor antagonist (1-850) blocks T3-mediated interaction of TRα and TRβ with nuclear receptor coactivator. Thyroid hormone receptor antagonist (1-850) has no effect on the activity of RARα .

AM580 (GMP) CD336 (GMP); NSC608001 (GMP); Ro 40-6055 (GMP)	Fluorescent Dye
AM580 (CD336) (GMP) is AM580 (HY-10475) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. AM580 is a selective RARα agonist .

AM580 (GMP) CD336 (GMP); NSC608001 (GMP); Ro 40-6055 (GMP)	Biochemical Assay Reagents
AM580 (CD336) (GMP) is AM580 (HY-10475) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. AM580 is a selective RARα agonist .

AGN 193109-d7
AGN 193109-d₇ is the deuterium labeled AGN 193109. AGN 193109 is a retinoid analog, and acts as a specific and highly effective antagonist of retinoic acid receptors (RARs), with Kds of 2 nM, 2 nM, and 3 nM for RARα, RARβ, and RARγ, respectively.

Adapalene-d3
Adapalene-d₃ is the deuterium labeled Adapalene. Adapalene (CD271), a third-generation synthetic retinoid, is widely used for the research of acne. Adapalene is a potent RAR agonist, with AC50s of 2.3 nM, 9.3 nM, and 22 nM for RARβ, RARγ, RARα, respectively. Adapalene also inhibits the enzymatic activity of GOT1 in a non-competitive manner. Adapalene exhibits anti-tumor activity[1][2][3].

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