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Results for "

REV-ERB

" in MedChemExpress (MCE) Product Catalog:
Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-117516
    SR10067

    		REV-ERB Neurological Disease Metabolic Disease
    SR10067 is a potent, selective and brain penetrant REV-ERB agonist. SR10067 has high affinity for Rev-Erbβ and Rev-Erbα with IC50 values of 160 nM and 170 nM, respectively. SR10067 can be used for the research of metabolic diseases and neuropsychiatric disorders .
    SR10067
  • HY-16988
    SR9011
    Maximum Cited Publications
    7 Publications Verification

    		 REV-ERB Cancer
    SR9011 is a REV-ERBα/β agonist with IC50s of 790 nM and 560 nM for REV-ERBα and REV-ERBβ, respectively.
    SR9011
  • HY-16988A
    SR9011 hydrochloride
    Maximum Cited Publications
    7 Publications Verification

    		 REV-ERB Cancer
    SR9011 hydrochloride is a REV-ERBα/β agonist with IC50s of 790 nM and 560 nM for REV-ERBα and REV-ERBβ, respectively.
    SR9011 hydrochloride
  • HY-163136
    Autophagy/REV-ERB-IN-1

    		Autophagy REV-ERB Cancer
    Autophagy/REV-ERB-IN-1 (compound 24) is a dual inhibitor of autophagy and REV-ERB. Autophagy/REV-ERB-IN-1 has anti-tumor activity with a CC50 value of 2.3 μM on BTB-474 cells.
    Autophagy/<em>REV-ERB</em>-IN-1
  • HY-163136A
    Autophagy/REV-ERB-IN-1 hydrochloride

    		Autophagy REV-ERB Cancer
    Autophagy/REV-ERB-IN-1 hydrochloride (Compound 24) is a dual autophagy and REV-ERB inhibitor with anticancer activity. Autophagy/REV-ERB-IN-1 (hydrochloride) has improved potency in blocking autophagy, enhanced toxicity against cancer cells. Autophagy/REV-ERB-IN-1 (hydrochloride) can be used for the research for melanoma .
    Autophagy/<em>REV-ERB</em>-IN-1 hydrochloride
  • HY-148103
    SR12418

    		REV-ERB Inflammation/Immunology
    SR12418 is a REV-ERB-specific synthetic ligand with IC50s of 68 nM and 119 nM for REV-ERBα and REV-ERBβ, respectively. SR12418 can be used in experimental autoimmune encephalomyelitis (EAE) and colitis research .
    SR12418
  • HY-148711
    STL1267

    		REV-ERB Metabolic Disease Inflammation/Immunology Cancer
    STL1267 is a potent and cross-the-blood-brain barrier REV-ERB agonist with a Ki value of 0.16 µM for REV-ERBα. STL1267 shows no cytotoxicity. STL1267 inhibits the gene expression of BMAL1 .
    STL1267
  • HY-14414
    GSK4112
    5 Publications Verification

    SR6452

    		 REV-ERB Apoptosis Metabolic Disease
    GSK4112 (SR6452) is a Rev-erbα agonist with an EC50 value of 0.4 μM. GSK4112 can be used as a chemical tool to probe the function of Rev-erbα in transcriptional repression, regulation of circadian biology, and metabolic pathways .
    GSK4112
  • HY-14415
    SR8278
    5+ Cited Publications

    		 REV-ERB Neurological Disease Metabolic Disease
    SR8278 is a REV-ERBα antagonist and inhibits the REV-ERBα transcriptional repression activity with an EC50 of 0.47 μM. SR8278 is used to regulate the metabolism in organisms and study biological rhythm. SR8278 also can be used for the research of Duchenne muscular dystrophy and Alzheimer's disease .
    SR8278
  • HY-103691A
    ARN5187 trihydrochloride

    		Autophagy Apoptosis Cancer
    ARN5187 trihydrochloride is a lysosomotropic REV-ERBβ ligand with a dual inhibitory activity toward REV-ERB-mediated transcriptional regulation and autophagy. ARN5187 trihydrochloride shows lysosomotropic potency and cytotoxicity. ARN5187 trihydrochloride induces apoptosis .
    ARN5187 trihydrochloride
  • HY-103691
    ARN5187

    		Autophagy Apoptosis Cancer
    ARN5187 is a lysosomotropic REV-ERBβ ligand with a dual inhibitory activity toward REV-ERB-mediated transcriptional regulation and autophagy. ARN5187 shows lysosomotropic potency and cytotoxicity. ARN5187 induces apoptosis .
    ARN5187
  • HY-156458
    SR-29065

    		REV-ERB Inflammation/Immunology
    SR-29065 is a selective REV-ERBα agonist, can be used for autoimmune disorders research .
    SR-29065
  • HY-117147
    GSK2945

    		Cytochrome P450 Metabolic Disease
    GSK2945 is a class of tertiary amine, and is a highly specific Rev-erbα/REV-ERBα (mouse/human reverse erythroblastosis virus α) antagonist with EC50s of 21.5 μM and 20.8 μM, respectively. GSK2945 enhances cholesterol 7α-hydroxylase (CYP7A1) level and cholesterol metabolism .
    GSK2945
  • HY-117147A
    GSK2945 hydrochloride

    		Cytochrome P450 Metabolic Disease
    GSK2945 hydrochloride is a class of tertiary amine, and is a highly specific Rev-erbα/REV-ERBα (mouse/human reverse erythroblastosis virus α) antagonist with EC50s of 21.5 μM and 20.8 μM, respectively. GSK2945 hydrochloride enhances cholesterol 7α-hydroxylase (CYP7A1) level and cholesterol metabolism .
    GSK2945 hydrochloride

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