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Results for "

RIPK3

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (1) CDK (2) Mixed Lineage Kinase (3) RIP kinase (12) Small Interfering RNA (siRNA) (3)
By Research Areas:	Cancer (4) Inflammation/Immunology (8)

Inhibitors & Agonists

Recombinant Proteins

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-131064

RIPK3-IN-1 1 Publications Verification	RIP kinase	Inflammation/Immunology
RIPK3-IN-1 is a *RIPK3* type II DFG-out inhibitor with an IC₅₀ of 9.1 nM. RIPK3-IN-1 inhibits RIPK1 and RIPK2 with IC₅₀s of 5.5 and >10 μM. RIPK3-IN-1 is also a c-Met kinase inhibitor with an IC₅₀ of 1.1 μM .

HY-RS11998

RIPK3 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
RIPK3 Human Pre-designed siRNA Set A contains three designed siRNAs for RIPK3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

RIPK3 Human Pre-designed siRNA Set A RIPK3 Human Pre-designed siRNA Set A

HY-RS11999

Ripk3 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Ripk3 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ripk3 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Ripk3 Mouse Pre-designed siRNA Set A Ripk3 Mouse Pre-designed siRNA Set A

HY-RS12000

Ripk3 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Ripk3 Rat Pre-designed siRNA Set A contains three designed siRNAs for Ripk3 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Ripk3 Rat Pre-designed siRNA Set A Ripk3 Rat Pre-designed siRNA Set A

HY-149393

RIPK3-IN-3	Mixed Lineage Kinase RIP kinase	Cancer
RIPK3-IN-3 (compound 20) is a selective inhibitor of RIP kinase RIPK3 (IC₅₀=10 nM). RIPK3 mediates the phosphorylation of Mixed Lineage Kinase (MLKL) and causes necroptosis, while RIPK3-IN-3 inhibits p-MLKL oligomerization and thereby inhibits necroptosis. RIPK3-IN-3 also downregulates CXCL5 secretion and inhibits AsPC-1 cell migration and invasion .

HY-156368

RIPK3-IN-4	RIP kinase	Inflammation/Immunology
RIPK3-IN-4 (Compound 42) is a *RIPK3* inhibitor. RIPK3-IN-4 inhibits HK-2 cell damage, necroptosis and inflammatory responses. RIPK3-IN-4 reduces Cisplatin (HY-17394)- and I/R-induced kidney damage, inflammatory response and necroptosis in acute kidney injury .

HY-148052

RIPK3-IN-2

RIP kinase Cancer

RIPK3-IN-2 is a RIP3 inhibitor. RIPK3-IN-2 can be used in diseases caused by or associate with activated necrotic pathways research .

RIPK3-IN-2	RIP kinase	Cancer
RIPK3-IN-2 is a RIP3 inhibitor. RIPK3-IN-2 can be used in diseases caused by or associate with activated necrotic pathways research .

HY-157039

RIPK1-IN-17	RIP kinase	Inflammation/Immunology
RIPK1/3-IN-17 (Compound 10) is a *RIPK1* and *RIPK3* inhibitor. RIPK1/3-IN-17 specifically inhibits necroptosis by inhibiting RIPK1, RIPK3, and MLKL phosphorylation .

HY-101872

GSK-872 Maximum Cited Publications 55 Publications Verification	RIP kinase	Inflammation/Immunology
GSK-872 is a *RIPK3* inhibitor, which binds RIP3 kinase domain with an IC₅₀ of 1.8 nM, and inhibits kinase activity with an IC₅₀ of 1.3 nM. GSK-872 decreases the RIPK3-mediated necroptosis and subsequent cytoplasmic translocation and expression of HMGB1, as well as ameliorates brain edema and neurological deficits in early brain injury ^[3].

HY-101872A

GSK-872 hydrochloride Maximum Cited Publications 55 Publications Verification	RIP kinase	Inflammation/Immunology
GSK-872 hydrochloride is a *RIPK3* inhibitor, which binds RIP3 kinase domain with an IC₅₀ of 1.8 nM, and inhibits kinase activity with an IC₅₀ of 1.3 nM. GSK-872 hydrochloride decreases the RIPK3-mediated necroptosis and subsequent cytoplasmic translocation and expression of HMGB1, as well as ameliorates brain edema and neurological deficits in early brain injury ^[3].

HY-104021

GSK840 1 Publications Verification GSK'840	RIP kinase	Inflammation/Immunology
GSK840 (GSK'840) is a receptor-interacting protein kinase 3 (RIP3 or RIPK3) inhibitor, which binds RIP3 kinase domain with an IC₅₀ of 0.9 nM, and inhibits kinase activity with an IC₅₀ of 0.3 nM .

HY-125402

GSK-843 3 Publications Verification GSK'843	RIP kinase Apoptosis	Inflammation/Immunology
GSK-843 (GSK'843) is a receptor-interacting protein kinase 3 (RIP3 or RIPK3) inhibitor, which binds RIP3 kinase domain with an IC₅₀ of 8.6 nM, and inhibits kinase activity with an IC₅₀ of 6.5 nM. GSK-843 can be used for the research of inflammation .

HY-151873

SZM679	RIP kinase	Inflammation/Immunology
SZM679 is a potent, orally active and selective *RIPK1* inhibitor with K_d values of 8.6 nM and >5000 nM for RIPK1 and RIPK3, respectively. SZM679 reverses the tumor necrosis factor-induced systemic inflammatory response. SZM679 decreases the Tau hyperphosphorylation, neuroinflammation, and the RIPK1 phosphorylation level in the hippocampus and cortex. SZM679 can be used in research of Alzheimer's disease (AD) .

HY-148365

NecroIr1	Mixed Lineage Kinase RIP kinase CDK	Cancer
NecroIr1 is an iridium(III) complex, serves as necroptosis inducers in Cisplatin (HY-17394)-resistant lung cancer cells (A549R). NecroIr1 selectively accumulates in mitochondria, leading to oxidative stress and loss of mitochondrial membrane potential (MMP). NecroIr1 activates receptor-interacting serine-threonine kinase 3 (RIPK3) and Mixed Lineage Kinase (MLKL), and regulates CDK4 expression .

HY-148366

NecroIr2	Mixed Lineage Kinase RIP kinase CDK	Cancer
NecroIr2 is an iridium(III) complex, serves as necroptosis inducers in Cisplatin (HY-17394)-resistant lung cancer cells (A549R). NecroIr2 selectively accumulates in mitochondria, leading to oxidative stress and loss of mitochondrial membrane potential (MMP). NecroIr2 activates receptor-interacting serine-threonine kinase 3 (RIPK3) and mixed lineage kinase domain-like pseudokinase (MLKL), and regulates CDK4 expression .

Recombinant Proteins Recommended:

Receptor-interacting Serine/Threonine-protein Kinase 3 (RIPK3)

Species:	Human (1) Mouse (1)
Tag:	His (2)
Source:	P. pastoris (2)

Cat. No.	Compare	Product Name	Species	Source

HY-P71855

	RIPK3 Protein, Human (P.pastoris, His) Receptor interacting protein 3; Receptor interacting serine threonine kinase 3; RIP like protein kinase 3; RIP-3; RIP-like protein kinase 3; RIPK 3	Human	P. pastoris
	RIPK3 is a kinase that controls necroptosis and apoptosis. In necroptosis, activated by TNF-α and ZBP1, RIPK3 phosphorylates MLKL, leading to membrane damage. RIPK3 Protein, Human (P.pastoris, His) is the recombinant human-derived RIPK3 protein, expressed by P. pastoris , with N-6*His labeled tag. The total length of RIPK3 Protein, Human (P.pastoris, His) is 518 a.a., with molecular weight of ~64 kDa.

HY-P71853

	RIPK3 Protein, Mouse (P.pastoris, His) RIPK3; Rip3; Receptor-interacting serine/threonine-protein kinase 3; EC 2.7.11.1; RIP-like protein kinase 3; Receptor-interacting protein 3; RIP-3; mRIP3	Mouse	P. pastoris
	RIPK3 Protein, participates in programmed necrosis (necroptosis) and apoptosis, contributing to diverse cellular processes. RIPK3 Protein, Mouse (P.pastoris, His) is the recombinant mouse-derived RIPK3 protein, expressed by P. pastoris , with N-6*His labeled tag. The total length of RIPK3 Protein, Mouse (P.pastoris, His) is 486 a.a., with molecular weight of ~64 kDa.


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