RNase

By Targets:	Antibiotic (2) Apoptosis (5) Autophagy (3) Bacterial (2) Biochemical Assay Reagents (1) c-Myc (1) DNA/RNA Synthesis (6) HIV (4) IRE1 (18) Isotope-Labeled Compounds (1) Mitophagy (3) PDGFR (3) Small Interfering RNA (siRNA) (6) VEGFR (3)
By Research Areas:	Cancer (15) Infection (9) Inflammation/Immunology (4) Metabolic Disease (2) Neurological Disease (3)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-155583

RNase L-IN-1	DNA/RNA Synthesis	Infection
RNase L-IN-1 (compound 17a) is an inhibitor of RNase L, or Ribonuclease L. RNase L degrades RNAs to prevent viral replication, and mediates the innate immune responses and inflammation .

HY-155583A

RNase L-IN-1 trihydrochloride	DNA/RNA Synthesis	Infection
RNase L-IN-1 (compound 17a) trihydrochloride is an inhibitor of RNase L or ribonuclease L. RNase L degrades RNA to prevent viral replication and mediates innate immune responses and inflammation .

HY-E70098

RNase H2	Others	Cancer
RNase H2 is the predominant source of RNase H activity in mammalian and human cells. RNase H2 protects genome integrity. RNase H2 has been associated with ribonucleotide removal from genomic DNA in yeast and mouse, where it is required for embryonic development .

HY-129046A

RNase A (10mg/mL, DNase free)	Others	Others
RNase A (10mg/mL, DNase free) is a ribonuclease used to catalyze RNA degradation without containing DNase. RNase A is often employed in cell cycle assay .

HY-RS12018

RNASE1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
RNASE1 Human Pre-designed siRNA Set A contains three designed siRNAs for RNASE1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

RNASE1 Human Pre-designed siRNA Set A RNASE1 Human Pre-designed siRNA Set A

HY-RS12019

RNASE2 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
RNASE2 Human Pre-designed siRNA Set A contains three designed siRNAs for RNASE2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

RNASE2 Human Pre-designed siRNA Set A RNASE2 Human Pre-designed siRNA Set A

HY-RS12020

RNASE3 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
RNASE3 Human Pre-designed siRNA Set A contains three designed siRNAs for RNASE3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

RNASE3 Human Pre-designed siRNA Set A RNASE3 Human Pre-designed siRNA Set A

HY-RS12021

RNASE4 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
RNASE4 Human Pre-designed siRNA Set A contains three designed siRNAs for RNASE4 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

RNASE4 Human Pre-designed siRNA Set A RNASE4 Human Pre-designed siRNA Set A

HY-RS12022

RNASE6 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
RNASE6 Human Pre-designed siRNA Set A contains three designed siRNAs for RNASE6 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

RNASE6 Human Pre-designed siRNA Set A RNASE6 Human Pre-designed siRNA Set A

HY-RS12023

RNASE7 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
RNASE7 Human Pre-designed siRNA Set A contains three designed siRNAs for RNASE7 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

RNASE7 Human Pre-designed siRNA Set A RNASE7 Human Pre-designed siRNA Set A

HY-P0229

Ribonulease T1, Aspergillus oryzae RNase T1	DNA/RNA Synthesis	Others
Ribonulease T1, Aspergillus oryzae (Rnase T1), is commonly used in biochemical research. Ribonuclease T1 is an endonuclease that can specifically degrade single stranded RNA. Ribonuclease T1 can form nucleoside 2 ', 3 '-cyclic phosphoric acid intermediates to cut the phosphodiester bond between 3' -guanosine residues and adjacent nucleoside 5 '-OH groups to produce 3' -GMP terminal oligonucleotides .

HY-129046

RNase A, bovine pancreas Ribonuclease A; EC 3.1.27.5; RNase A	Others	Others
Ribonuclease A (EC 3.1.27.5) cleaves RNA 3′ to pyrimidines and actively cleaves RNA at every pyrimidine residue. Ribonuclease A catalyzes the hydrolysis of single stranded RNA in the absence of metal ions or cofactors .

HY-108882A

*Recombinant DNase I (RNase-free)*	Others	Others
Recombinant DNase I (RNase-free) is a recombinant deoxyribonuclease that degrades DNA. Recombinant DNase I is essential for limiting inflammatory responses and maintaining homeostasis .

HY-N12387

Laccaic acid C

Others Infection

Laccaic acid C is an potent inhibitor of RNase H with an IC₅₀ of 8.1 μM. Laccaic acid C also inhibits viral proliferation in cell .

Laccaic acid C	Others	Infection
Laccaic acid C is an potent inhibitor of RNase H with an IC₅₀ of 8.1 μM. Laccaic acid C also inhibits viral proliferation in cell .

HY-145425

PAIR2	IRE1	Cancer
PAIR2 is a potent and selective partial antagonist of IRE1α RNase. PAIR2 can completely occupy IRE1α’s ATP-binding site in cells and block the ability of a potent KIRA to inhibit XBP1 splicing .

HY-139212

IXA6

IRE1 Others

IXA6 is a novel IRE1/XBP1s activator, and can induce IRE1 RNase activity .

IXA6	IRE1	Others
IXA6 is a novel IRE1/XBP1s activator, and can induce IRE1 RNase activity .

HY-150759

HIV-1 inhibitor-45	HIV	Infection
HIV-1 inhibitor-45 (compound IA-6) is a potent *HIV-1 RNase* H inhibitor with an IC₅₀** value of 0.067 μM. HIV-1 inhibitor-45 shows an antiviral activity .

HY-113767

Momordin II	Others	Metabolic Disease
Momordin II, an oleanane-type triterpene glycoside, is a ribosome inactivating protein. Momordin II inhibits cell-free protein synthesis, releases adenine from rat liver ribosomes and from DNA, and has no RNase activity .

HY-132580

Tofersen BIIB067; ISIS-SOD1Rx	DNA/RNA Synthesis	Neurological Disease
Tofersen (BIIB067) is an antisense oligonucleotide that mediates RNase H-dependent degradation of superoxide dismutase 1 (SOD1) mRNA to reduce the synthesis of SOD1 protein. Tofersen can be used for the research of amyotrophic lateral sclerosis (ALS) .

HY-17624

Framycetin Neomycin B; Fradiomycin B	Bacterial Antibiotic	Infection
Framycetin (Neomycin B), an aminoglycoside antibiotic, is a potent RNase P cleavage activity inhibitor with a K_i of 35 μM. Framycetin competes for specific divalent metal ion binding sites in RNase P RNA. Framycetin inhibits hammerhead ribozyme with a K_i of 13.5 μM. Framycetin, a 5″-azido neomycin B precursor, binds the Drosha site in miR-525 and is used for hepatic encephalopathy and enteropathogenic E. coli infections .

HY-17624A

Framycetin sulfate Neomycin B sulfate; Fradiomycin B sulfate	Antibiotic Bacterial	Infection
Framycetin sulfate (Neomycin B sulfate), an aminoglycoside antibiotic, is a potent RNase P cleavage activity inhibitor with a K_i of 35 μM. Framycetin sulfate competes for specific divalent metal ion binding sites in RNase P RNA. Framycetin sulfate inhibits hammerhead ribozyme with a K_i of 13.5 μM. Framycetin sulfate, a 5″-azido neomycin B precursor, binds the Drosha site in miR-525 and is used for hepatic encephalopathy and enteropathogenic E. coli infections .

HY-D0846

Diethyl pyrocarbonate	Biochemical Assay Reagents	Neurological Disease
Diethyl pyrocarbonate is a potent, orally active, non-specific chemical inhibitor of RNase. Diethyl pyrocarbonate has been useful in vitro as an agent relatively specific for binding to imidazole of histidine. Diethyl pyrocarbonate inhibits central chemosensitivity in rabbits. Diethyl pyrocarbonate can modify Ser, Thr, His and Tyr residues. Diethyl pyrocarbonate can be used for modeling .

HY-W028350

NSC727447	HIV DNA/RNA Synthesis	Infection
NSC727447 is an inhibitor of ribonuclease H (Rnase H) of HIV-1 and HIV-2. NSC727447 has little activity against E. coli RNase H, but great selectivity over human Rnase H, with IC₅₀s value of 2.0 μM, 2.5 μM, 100 μM, 10.6 μM, respectively .

HY-107400

B I09

1 Publications Verification

IRE1 Cancer

B I09 is an IRE-1 RNase inhibitor, with an IC₅₀ of 1230 nM.
HY-154828

Uridine 3′,5′-diphosphate

3′,5′-UDP
DNA/RNA Synthesis Others

Uridine 3′,5′-diphosphate (3′,5′-UDP; Compound pUp) is a competitive RNase inhibitor .

B I09 1 Publications Verification	IRE1	Cancer
B I09 is an IRE-1 RNase inhibitor, with an IC₅₀ of 1230 nM.

Uridine 3′,5′-diphosphate 3′,5′-UDP	DNA/RNA Synthesis	Others
Uridine 3′,5′-diphosphate (3′,5′-UDP; Compound pUp) is a competitive *RNase* inhibitor .

HY-114368A

Kira8 Hydrochloride AMG-18 Hydrochloride	IRE1	Inflammation/Immunology
Kira8 Hydrochloride (AMG-18 Hydrochloride) is a mono-selective IRE1α inhibitor that allosterically attenuates *IRE1α RNase* activity with an IC₅₀** of 5.9 nM .

HY-114368

Kira8 5+ Cited Publications AMG-18	IRE1	Inflammation/Immunology
Kira8 (AMG-18) is a mono-selective IRE1α inhibitor that allosterically attenuates *IRE1α RNase* activity with an IC₅₀** of 5.9 nM .

HY-19708

KIRA6 10+ Cited Publications	IRE1	Metabolic Disease Inflammation/Immunology Cancer
KIRA6 is an advanced small-molecule IRE1α RNase kinase inhibitor with an IC₅₀ of 0.6 µM . KIRA6 can trigger an apoptotic response .

HY-124646

KIRA-7	IRE1	Inflammation/Immunology
KIRA-7, an imidazopyrazine compound, binds the IRE1α kinase (IC₅₀ of 110 nM) to allosterically inhibit its RNase activity. KIRA-7 has an anti-fibrotic effect .

HY-104040

MKC8866 5+ Cited Publications Orin1001	IRE1	Cancer
MKC8866, a salicylaldehyde analog, is a potent, selective IRE1 RNase inhibitor with an IC₅₀ of 0.29 μM in human vitro. MKC8866 strongly inhibits Dithiothreitol-induced X-box-binding protein 1-spliced (XBP1s) expression with an EC₅₀ of 0.52 μM and unstresses RPMI 8226 cells with an IC₅₀ of 0.14 μM . MKC8866 inhibits IRE1 RNase in breast cancer cells leading to the decreased production of pro-tumorigenic factors and it can inhibits prostate cancer (PCa) tumor growth .

HY-U00459

GSK2850163 3 Publications Verification	IRE1	Cancer
GSK2850163 is a novel inhibitor of inositol-requiring enzyme-1 alpha (IRE1α) which can inhibit IRE1α kinase activity and RNase activity with IC₅₀s of 20 and 200 nM, respectively.

HY-U00459B

GSK2850163 hydrochloride	IRE1	Cancer
GSK2850163 hydrochloride is a novel inhibitor of inositol-requiring enzyme-1 alpha (IRE1α) which can inhibit IRE1α kinase activity and RNase activity with IC₅₀s of 20 and 200 nM, respectively.

HY-132572

HIV-1 integrase inhibitor 9	HIV	Infection
HIV-1 integrase inhibitor 9 (compound 8a) is a potent *HIV-1 RNase* H inhibitor with an IC₅₀** of 12.3 μM. HIV-1 integrase inhibitor 9 shows an antiviral activity .

HY-17537

APY29 5+ Cited Publications	IRE1	Cancer
APY29, an ATP-competitive inhibitor, is an allosteric modulator of IRE1α which inhibits IRE1α autophosphorylation by binding to the ATP-binding pocket with IC₅₀ of 280 nM. APY29 acts as a ligand that allosterically activates IRE1α adjacent RNase domain .

HY-N10776

Kaempferol-3-O-(6′′-galloyl)-β-glucopyranoside	HIV	Infection
Kaempferol-3-O-(6′′-galloyl)-β-glucopyranoside is a glucopyranoside. Kaempferol-3-O-(6′′-galloyl)-β-glucopyranoside inhibts HIV-2 RNase H with an IC₅₀ value of 5.19 μM .

HY-10255A

Sunitinib Maximum Cited Publications 46 Publications Verification SU 11248	VEGFR PDGFR IRE1 Mitophagy Autophagy Apoptosis	Cancer
Sunitinib (SU 11248) is a multi-targeted receptor tyrosine kinase inhibitor with IC₅₀s of 80 nM and 2 nM for VEGFR2 and PDGFRβ, respectively . Sunitinib, an ATP-competitive inhibitor, effectively inhibits autophosphorylation of Ire1α by inhibiting autophosphorylation and consequent RNase activation .

HY-10255

Sunitinib Malate Maximum Cited Publications 46 Publications Verification SU 11248 Malate	PDGFR VEGFR IRE1 Mitophagy Autophagy Apoptosis	Cancer
Sunitinib Malate (SU 11248 Malate) is a multi-targeted receptor tyrosine kinase inhibitor with IC₅₀s of 80 nM and 2 nM for VEGFR2 and PDGFRβ, respectively . Sunitinib Malate, an ATP-competitive inhibitor, effectively inhibits autophosphorylation of Ire1α by inhibiting autophosphorylation and consequent RNase activation .

HY-153713

MYC-RIBOTAC	c-Myc Apoptosis	Cancer
MYC-RIBOTAC is a ribonuclease-targeting chimera (RIBOTAC) to MYC internal ribosome entry site (IRES).MYC-RIBOTAC contains a MYC mRNA-binder and a small molecule that recruits and locally activates RNase L1 and decreases the mRNA and protein expression levels of MYC, induces apoptosis. MYC-RIBOTAC can be used for anticancer research .

HY-10255AS

Sunitinib-d10 SU 11248-d10
Sunitinib-d₁₀ is a deuterium labeled Sunitinib. Sunitinib is a multi-targeted receptor tyrosine kinase inhibitor with IC50s of 80 nM and 2 nM for VEGFR2 and PDGFRβ, respectively[1]. Sunitinib, an ATP-competitive inhibitor, effectively inhibits autophosphorylation of Ire1α by inhibiting autophosphorylation and consequent RNase activation[2].

HY-10255AS1

Sunitinib-d4	Isotope-Labeled Compounds VEGFR PDGFR IRE1 Mitophagy Autophagy Apoptosis	Cancer
Sunitinib-d₄ is the deuterium labeled Sunitinib. Sunitinib (SU 11248) is a multi-targeted receptor tyrosine kinase inhibitor with IC50s of 80 nM and 2 nM for VEGFR2 and PDGFRβ, respectively[1]. Sunitinib, an ATP-competitive inhibitor, effectively inhibits autophosphorylation of Ire1α by inhibiting autophosphorylation and consequent RNase activation[2].

HY-U00460

3,6-DMAD hydrochloride	IRE1	Cancer
3,6-DMAD hydrochloride, an acridine derivative, is a potent IRE1α-XBP1s pathway inhibitor. 3,6-DMAD hydrochloride promotes IL-6 secretion via the IRE1α-XBP1s pathway. 3,6-DMAD hydrochloride inhibits IRE1α oligomerization and endoribonuclease (RNase) activity. 3,6-DMAD hydrochloride can be used for research of cancer .

HY-136735

IRE1α kinase-IN-1	IRE1	Neurological Disease Cancer
IRE1α kinase-IN-1 is a highly selective IRE1α (ERN1) inhibitor, with an IC₅₀ of 77 nM. IRE1α kinase-IN-1 displays 100-fold selectivity for IRE1α over the IRE1β isoform. IRE1α kinase-IN-1 inhibits ER stress-induced IRE1α oligomerization and autophosphorylation, and also inhibits IRE1α RNase activity (IC₅₀=80 nM) .

HY-U00460B

3,6-DMAD dihydrochloride	IRE1	Cancer
3,6-DMAD dihydrochloride, an acridine derivative, is a potent IRE1α-XBP1s pathway inhibitor. 3,6-DMAD dihydrochloride promotes IL-6 secretion via the IRE1α-XBP1s pathway. 3,6-DMAD dihydrochloride inhibits IRE1α oligomerization and endoribonuclease (RNase) activity. 3,6-DMAD dihydrochloride can be used for research of cancer .

HY-145422

KIRA9	IRE1 Apoptosis	Others
KIRA9 is a potent IRE1 inhibitor (IC₅₀=4.8 μM in INS-1 cells). KIRA9 is able to fully engage the ATP-binding site of IRE1α. KIRA9 can block ER-localized mRNA decay and apoptosis .

Cat. No.	Product Name

HY-E0077

Adhesive Aluminium Foil Plate Seal
MCE adhesive aluminium foil plate seals are of strong adhesive that can reduce chance of well-to-well contamination and sample evaporation when applied to microplates. This aluminium foil seal is suitable for long-term storage of samples at -80°C. The high integrity sealing materials give the best protection against evaporation and contamination. The aluminium foil seal features excellent chemical resistance to DMSO and DNase- & RNase- free. MCE adhesive foil seal is pierceable, peelable and easy-to-use.

Adhesive Aluminium Foil Plate Seal

MCE adhesive aluminium foil plate seals are of strong adhesive that can reduce chance of well-to-well contamination and sample evaporation when applied to microplates. This aluminium foil seal is suitable for long-term storage of samples at -80°C. The high integrity sealing materials give the best protection against evaporation and contamination. The aluminium foil seal features excellent chemical resistance to DMSO and DNase- & RNase- free. MCE adhesive foil seal is pierceable, peelable and easy-to-use.

Cat. No.	Product Name	Type

HY-D0846

Diethyl pyrocarbonate	Biochemical Assay Reagents
Diethyl pyrocarbonate is a potent, orally active, non-specific chemical inhibitor of RNase. Diethyl pyrocarbonate has been useful in vitro as an agent relatively specific for binding to imidazole of histidine. Diethyl pyrocarbonate inhibits central chemosensitivity in rabbits. Diethyl pyrocarbonate can modify Ser, Thr, His and Tyr residues. Diethyl pyrocarbonate can be used for modeling .

HY-156262

DEPC-Treated Water	Biochemical Assay Reagents
DEPC-Treated Water is ultrapure water that has been sterilized by high temperature and high pressure and does not contain nuclease. It can avoid contamination by non-specific endonucleases and exonucleases and does not affect RNase activity .

Cat. No.	Product Name	Target	Research Area

HY-P0326

S Tag Peptide

Peptides Others

S Tag Peptide is a 15 amino acid peptide derived from RNase A.

Cat. No.	Product Name

HY-K1033

RNase Inhibitor

1 Publications Verification

RNase Inhibitor is a 50 kDa recombinant protein expressed in E.coli, and can specifically inhibit RNase A, B and C.
HY-KE7058

RNase H

RNase H is an endoribonuclease expressed and purified from Escherichia coli and can specifically hydrolyze RNA in DNA-RNA hybrid strands.
HY-KE7055

RNase R

RNase R is a magnesium ion-dependent 3'-5' exoribonuclease that can increase the abundance of circular RNA by degrading linear RNA in mixed RNA, thereby enriching circular RNA.
HY-KE7056

RNase III

RNase III is a specific exonuclease expressed in E.coli that can cleave dsRNA into 12-15 bp dsRNA fragments.
HY-KE8004

Reverse Transcriptase

Reverse Transcriptase is a reverse transcriptase that clones and expresses the deletion mutant RNase H- of M-MuLV through genetic recombination technology.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N10776

Kaempferol-3-O-(6′′-galloyl)-β-glucopyranoside	Structural Classification Flavonoids Leguminosae Flavonones Source classification Sophora japonica (L.) Schott Plants	HIV
Kaempferol-3-O-(6′′-galloyl)-β-glucopyranoside is a glucopyranoside. Kaempferol-3-O-(6′′-galloyl)-β-glucopyranoside inhibts HIV-2 RNase H with an IC₅₀ value of 5.19 μM .

HY-N12387

Laccaic acid C	Quinones Structural Classification Animals Anthraquinones Source classification	Others
Laccaic acid C is an potent inhibitor of RNase H with an IC₅₀ of 8.1 μM. Laccaic acid C also inhibits viral proliferation in cell .

HY-113767

Momordin II	Triterpenes Structural Classification Terpenoids Source classification Cucurbitaceae Plants Momordica charantia Linn.	Others
Momordin II, an oleanane-type triterpene glycoside, is a ribosome inactivating protein. Momordin II inhibits cell-free protein synthesis, releases adenine from rat liver ribosomes and from DNA, and has no RNase activity .

Species:	Human (8) E.coli (1)
Tag:	His (9) SUMO (1) Tag Free (1)
Source:	HEK293 (5) Sf9 insect cells (1) E. coli (4)

Cat. No.	Compare	Product Name	Species	Source

HY-P71089

	Rnase 1 Protein, Human (HEK293, His) Ribonuclease Pancreatic; HP-RNase; RIB-1; RNase UpI-1; Ribonuclease 1; RNase 1; Ribonuclease A; RNase A; RNase1; RIB1; RNS1	Human	HEK293
	The RNase 1 protein functions as an endonuclease capable of catalyzing RNA cleavage specific to the 3' side of pyrimidine nucleotides. This enzymatic activity extends to single- and double-stranded RNA, demonstrating its versatility in RNA substrate recognition and processing. Rnase 1 Protein, Human (HEK293, His) is the recombinant human-derived Rnase 1 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Rnase 1 Protein, Human (HEK293, His) is 128 a.a., with molecular weight of 21-28 kDa.

HY-P70538

Rnase 3 Protein, Human (HEK293, His)

Eosinophil Cationic Protein; ECP; Ribonuclease 3; RNase 3; RNase3; ECP; RNS3
Human HEK293

HY-P71089Y

	Rnase 1 Protein, Human (HEK293, His, solution) Ribonuclease Pancreatic; HP-RNase; RIB-1; RNase UpI-1; Ribonuclease 1; RNase 1; Ribonuclease A; RNase A; RNase1; RIB1; RNS1	Human	HEK293
	The RNase 1 protein functions as an endonuclease capable of catalyzing RNA cleavage specific to the 3' side of pyrimidine nucleotides. This enzymatic activity extends to single- and double-stranded RNA, demonstrating its versatility in RNA substrate recognition and processing. Rnase 1 Protein, Human (HEK293, His, solution) is the recombinant human-derived Rnase 1 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Rnase 1 Protein, Human (HEK293, His, solution) is 128 a.a., with molecular weight of 18-28 kDa.

HY-P71261

	RNASE6 Protein, Human (HEK293, His) Ribonuclease K6; RNase K6; RNase6; RNS6	Human	HEK293
	RNASE6 Protein, a pyrimidine-preferring ribonuclease, exhibits potent antibacterial activity against diverse bacteria, including P. aeruginosa, A. baumanii, and E. coli. Its effect is independent of ribonuclease activity, inducing bacterial membrane disruption and Gram-negative bacteria agglutination, emphasizing its bactericidal properties. RNASE6's robust antibacterial activity suggests a potential role in preserving urinary tract sterility. RNASE6 Protein, Human (HEK293, His) is the recombinant human-derived RNASE6 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of RNASE6 Protein, Human (HEK293, His) is 127 a.a., with molecular weight of ~22.0 kDa.

HY-P7503

	Angiogenin Protein, Human rHuAngiogenin; ANG; RNase5; Angiogenin	Human	E. coli
	Angiogenin Protein, Human is a potent inducer of new blood vessel formation. Angiogenin may contribute to the malignant transformation of gliomas as well as to angiogenic processes.

HY-P700644

	Angiogenin Protein,Human (His) rHuAngiogenin; ANG; RNase5; Angiogenin	Human	E. coli
	Human angiopoietin protein is a ribonuclease that cleaves tRNA to generate stress-induced fragments, inhibits protein synthesis and triggers stress granule assembly. It binds to endothelial cell actin, undergoes endocytosis and nuclear translocation, and stimulates ribosomal RNA synthesis. Angiogenin Protein,Human (His) is the recombinant human-derived Angiogenin protein,Human, expressed by E. coli , with N-6*His labeled tag. The total length of Angiogenin Protein,Human (His) is 122 a.a., with molecular weight of 18.0 kDa.

HY-P71470

	Ribonuclease J/RnJ Protein, Synechocystis sp. (His-SUMO) rnj; slr0551; Ribonuclease J; RNase J	Others	E. coli
	Ribonuclease J/RnJ Proteinas, an enzyme with 5'-3' exonuclease activity and potential endonuclease function, is crucial in ribosomal RNA (rRNA) maturation. It also plays a role in mRNA maturation/decay, contributing to intricate RNA processing, ensuring precise maturation, and quality control in the cellular environment. Ribonuclease J/RnJ Protein, Synechocystis sp. (His-SUMO) is the recombinant Ribonuclease J/RnJ protein, expressed by E. coli , with N-His, N-SUMO labeled tag. The total length of Ribonuclease J/RnJ Protein, Synechocystis sp. (His-SUMO) is 640 a.a., with molecular weight of ~86.4 kDa.

HY-P700300

	Ribonuclease R (rnr) protein, E.coli (His) Ribonuclease R; rnr; RNase R; Protein VacB; vacB; yjeC	E.coli	E. coli
	Ribonuclease R (RNase R) is a 3'-5' exoribonuclease crucial for structured RNA maturation, degrading rRNAs, tRNAs, and SsrA/tmRNA. It modulates ompA mRNA stability in the stationary phase, exhibiting processive activity and helicase function. RNase R, along with PNPase, ensures rRNA quality during steady-state growth and contributes to virulence gene expression in E. coli. Ribonuclease R (rnr) protein, E.coli (His) is the recombinant E. coli-derived Ribonuclease R, expressed by E. coli , with N-6*His labeled tag. The total length of Ribonuclease R (rnr) protein, E.coli (His) is 813 a.a., with molecular weight of ~90 kDa.

HY-P76006

	RNASET2 Protein, Human (sf9, His) Ribonuclease T2; Ribonuclease 6; RNaseT2; RNase6PL	Human	Sf9 insect cells
	The RNASET2 protein is a ribonuclease that makes a crucial contribution to the innate immune response by degrading microbial RNA sensed by TLR8. It preferentially cleaves single-stranded RNA, generating products that promote RNA-dependent TLR8 activation. RNASET2 Protein, Human (sf9, His) is the recombinant human-derived RNASET2 protein, expressed by Sf9 insect cells , with C-His labeled tag. The total length of RNASET2 Protein, Human (sf9, His) is 232 a.a., with molecular weight of ~35 kDa.

HY-P71015

	RNASET2 Protein, Human (HEK293, His) Ribonuclease T2; 3.1.27.-; Ribonuclease 6; RNase6PL	Human	HEK293
	The RNASET2 protein is a ribonuclease that makes a crucial contribution to the innate immune response by degrading microbial RNA sensed by TLR8. It preferentially cleaves single-stranded RNA, generating products that promote RNA-dependent TLR8 activation. RNASET2 Protein, Human (HEK293, His) is the recombinant human-derived RNASET2 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of RNASET2 Protein, Human (HEK293, His) is 232 a.a., with molecular weight of 38-45 kDa.

Cat. No.	Product Name	Chemical Structure

HY-10255AS1

Sunitinib-d4
Sunitinib-d₄ is the deuterium labeled Sunitinib. Sunitinib (SU 11248) is a multi-targeted receptor tyrosine kinase inhibitor with IC50s of 80 nM and 2 nM for VEGFR2 and PDGFRβ, respectively[1]. Sunitinib, an ATP-competitive inhibitor, effectively inhibits autophosphorylation of Ire1α by inhibiting autophosphorylation and consequent RNase activation[2].

Cat. No.	Product Name	Application	Reactivity

HY-P82569

RNase L Antibody (YA2314)

PRCA1; Ribonuclease4; RibonucleaseL; RNase L; RNasel; RNS4
WB Human


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