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RON

" in MedChemExpress (MCE) Product Catalog:

By Targets:	c-Met/HGFR (8) Cytochrome P450 (1) IGF-1R (1) Insulin Receptor (1) TAM Receptor (2)
By Research Areas:	Cancer (11) Endocrinology (1) Infection (1)

11

Inhibitors & Agonists

1

Inhibitory Antibodies

2

Recombinant Proteins

2

Antibodies

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

SYN1143	c-Met/HGFR	Cancer
SYN1143 is a potent, selective and orally active dual inhibitor of *c-Met/RON, with IC₅₀s of 4 and 9 nM, respectively. SYN1143 has weak inhibitory activity on Lck, Tie2, Src, and BTK* with IC₅₀s ranging from 160 to 710 nM. SYN1143 can be used for the research of cancers that RON and c-Met are activated .

NCGC00262650	Others	Infection
NCGC00262650 is a potent *apical membrane antigen 1-rhoptry neck protein 2 (AMA1-RON2) interaction* inhibitor. NCGC00262650 can block entry of merozoites into red blood cells .

MK-8033 2 Publications Verification	c-Met/HGFR	Cancer
MK-8033 is an orally active ATP competitive *c-Met/Ron* dual inhibitor (IC₅₀s: 1 nM (c-Met),7 nM (Ron)), with preferential binding to the activated kinase conformation. MK-8033 can be used in the research of cancers, such as breast and bladder cancers, non-small cell lung cancers (NSCLCs) .

HY-155812

Tyrosine kinase-IN-6

c-Met/HGFR Cancer

Tyrosine kinase-IN-6 is a potent and promising RON splice variants inhibitor with anti-cancer and o?antineoplastic effects .

OSI-296	c-Met/HGFR	Cancer
OSI-296 is a potent, oral and selective inhibitor of cMET and *RON* kinases. OSI-296 shows in vivo efficacy in MKN45 tumor xenografts models and well tolerated .

MK-8033 hydrochloride 2 Publications Verification	c-Met/HGFR	Cancer
MK-8033 hydrochloride is an orally active ATP competitive *c-Met/Ron* dual inhibitor (IC₅₀s: 1 nM (c-Met),7 nM (Ron)), with preferential binding to the activated kinase conformation. MK-8033 hydrochloride can be used in the research of cancers, such as breast and bladder cancers, non-small cell lung cancers (NSCLCs) .

AMG-208 1 Publications Verification	c-Met/HGFR Cytochrome P450	Cancer
AMG-208 is an orally active *c-Met/RON* dual selective inhibitor with an IC₅₀ of 9 nM for c-Met. AMG-208 is a CYP3A4 inhibitor with an IC₅₀ of 32 μM. AMG-208 has anti-cancer activity .

Glumetinib 1 Publications Verification GumaRONtinib; SCC244	c-Met/HGFR	Cancer
Glumetinib (SCC244) is a highly selective, orally bioavailable, ATP-competitive c-Met inhibitor with an IC₅₀ of 0.42 nM. Glumetinib has greater than 2400-fold selectivity for c-Met over those 312 kinases evaluated, including the c-Met family member RON and highly homologous kinases Axl, Mer, TyrO3. Antitumor activity .

BMS-754807 5+ Cited Publications	IGF-1R Insulin Receptor	Endocrinology Cancer
BMS-754807 is a potent and reversible IGF-1R/IR inhibitor (IC₅₀=1.8 and 1.7 nM, respectively; K_i=<2 nM for both). BMS-754807 also shows potent activities against Met, RON, TrkA, TrkB, AurA, and AurB with IC₅₀ values of 6, 44, 7, 4, 9, and 25 nM, respectively .

BMS 777607 Maximum Cited Publications 10 Publications Verification BMS 817378	c-Met/HGFR TAM Receptor	Cancer
BMS 777607 (BMS 817378) is a Met-related inhibitor for c-Met, Axl, *Ron* and Tyro3 with IC₅₀s of 3.9 nM, 1.1 nM, 1.8 nM and 4.3 nM, respectively, and 40-fold more selective for Met-related targets than Lck, VEGFR-2, and TrkA/B, with more than 500-fold greater selectivity versus all other receptor and non receptor kinases .

HY-162085

Axl-IN-17

TAM Receptor Cancer

Axl-IN-17 (compound 13c) is an orally active, selective AXL inhibitor with an IC₅₀ value of 3.2 nM. Axl-IN-17 reveals antitumor efficacy .

Cat. No.	Product Name	Target	Research Area

Narnatumab IMC-RON8; LY3012219; Anti-MSPR/RON/CD136 Reference Antibody (narnatumab)	Inhibitory Antibodies	Cancer
Narnatumab (IMC-RON8) is a neutralizing human monoclonal antibody that blocks *RON* binding to its ligand, macrophage-stimulating protein (MSP), with a K_d of 32 pM. Narnatumab can be used for the research of cancer .

Species:	Human (2)
Tag:	His (2)
Source:	HEK293 (2)

Cat. No.	Compare	Product Name	Species	Source

	RON/MSPR Protein, Human (HEK293, His) Macrophage-stimulating protein receptor; p185-RON; MST1R; PTK8	Human	HEK293
	RON/MSPR protein is a receptor tyrosine kinase that transduces signals by binding to MST1 ligand and regulates cell survival, migration, and differentiation. Ligand binding induces RON autophosphorylation, creating docking sites for downstream molecules. RON/MSPR Protein, Human (HEK293, His) is the recombinant human-derived RON/MSPR protein, expressed by HEK293 , with C-His labeled tag. The total length of RON/MSPR Protein, Human (HEK293, His) is 547 a.a., with molecular weight of ~70 kDa.

HY-P77180A

RON/MSPR Protein, Human (HEK293, C-His)

Macrophage-stimulating protein receptor; p185-RON; MST1R; PTK8
Human HEK293

Cat. No.	Product Name	Application	Reactivity

HY-P82658

RNA Polymerase beta Antibody (YA2403)

gRON; nitB; rif; RNA pol beta; RNA polymerase subunit beta; RON; rpoB; stl; stv; tabD; Transcriptase subunit beta
WB, IP Escherichia Coli
HY-P81384

RON Antibody (YA1129)

MST1R; PTK8; RON; Macrophage-stimulating protein receptor; MSP receptor; CDw136; Protein-tyrosine kinase 8; p185-RON; CD136
IHC-P Human

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